Hub : Genes

COL4A4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Female)	0.1968	0.1140	6.6e-02	-0.008	NA	-0.009	NA	-0.009	6.3e-01	NA	7.6e-01	NA	8.1e-01
2	GTEx	Lung	0.1269	0.0485	4.4e-03	0.040	NA	0.010	NA	0.044	4.6e-04	NA	5.0e-02	NA	2.8e-04
3	GTEx	Nerve Tibial	0.2461	0.0590	2.3e-05	0.055	NA	0.097	NA	0.079	9.5e-05	NA	2.2e-07	NA	3.1e-06
4	GTEx	Thyroid	0.1070	0.0430	2.0e-03	0.005	NA	-0.001	NA	0.000	1.3e-01	NA	3.7e-01	NA	3.1e-01
5	YFS	Blood	0.0787	0.0141	0.0e+00	0.136	0.122	0.153	0.138	0.155	3.4e-42	6.9e-38	8.4e-48	5.9e-43	3.2e-48
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.0630	0.0350	9.9e-03	-0.001	0.022	-0.004	NA	-0.002	3.6e-01	1.2e-02	9.1e-01	NA	5.0e-01
7	TCGA	Prostate Adenocarcinoma	0.0858	0.0377	3.1e-03	0.001	0.015	0.004	NA	0.011	2.2e-01	9.8e-03	1.1e-01	NA	2.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	1.5	-0.1	-0.3	1.0	0.5	-0.2	-1.2	0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	2.8	-0.6	0.3	-0.4	0.9	-1.0	-1.7	-0.8
Depressed Affect (Nagel 2018)	1.5	3.2	8.8	-1.5	-1.0	-0.2	-2.6	3.0	1.9	0.3
Depression (Nagel 2018)	0.2	0.4	0.9	-0.6	-0.5	-0.5	-0.8	0.9	0.3	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	0.2	0.4	-0.1	0.3	-0.5	0.5	-0.8
Neuroticism (Nagel 2018)	0.7	1.7	4.5	-1.6	-0.6	-0.7	-2.1	1.5	1.0	0.7
Schizophrenia (2018)	0.6	1.3	2.7	-0.8	0.6	-1.4	0.8	-1.1	-1.2	-1.6
Schizophrenia vs Biploar Disorder	0.5	0.7	3.7	-0.6	0.3	-0.7	0.3	-0.1	0.2	-1.9
Worry (Nagel 2018)	0.8	1.7	3.6	-1.4	-0.1	-1.4	-1.9	1.0	1.4	1.2
Alzheimer’s Disease (in mother)	0.8	0.9	3.6	1.9	0.1	-1.4	-0.4	-0.4	-0.2	0.4
Alzheimer’s Disease (in father)	1.2	1.3	2.9	-0.0	0.8	-1.7	1.2	-1.6	-0.6	-1.1
Alzheimer’s Disease (including proxy)	0.8	1.2	3.2	1.5	0.9	-1.8	0.3	-1.1	-0.3	-0.8
Crohns Disease (2017)	0.3	0.6	1.5	1.2	-0.4	0.8	0.3	-0.9	-1.0	-0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.4	0.0	0.2	0.5	-0.3	-0.5	-0.6
Ulcerative Colitis (UC)	0.3	0.5	2.8	-1.7	0.2	-0.1	-0.0	0.6	0.4	-0.5
Major Depression (MDD)	1.3	1.6	6.5	2.5	-0.9	0.6	1.1	-0.9	-1.0	-0.6
Reaction Time	0.3	0.5	1.7	1.3	-0.6	0.3	-0.1	0.5	0.3	1.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.8	-0.3	0.6	-0.3	-0.5	0.2	0.9	-0.6
Breast Cancer	0.5	1.3	3.5	-0.3	0.4	-0.3	-1.1	1.9	1.4	1.4
Ovarian Cancer	1.5	2.0	4.1	2.0	-1.6	-0.8	0.8	-1.6	-1.2	-1.5
Prostate Cancer	0.8	1.2	2.6	-1.1	-0.6	-1.6	-0.3	0.9	1.6	-0.8
Age at First Birth	0.3	0.5	1.0	0.4	-1.0	-0.3	0.7	-0.8	-0.6	0.7
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.4	0.0	0.2	0.2	-0.5	0.0	0.0
Body Mass Index (BMI) (2010)	2.9	4.0	8.9	0.9	0.1	0.1	2.7	-3.0	-2.7	-1.9
Coronary Artery Disease (CAD)	1.7	2.1	4.0	-1.3	-1.9	-0.7	-0.9	1.9	2.0	0.9
Crohns Disease (2012)	0.8	1.2	4.6	1.2	-1.2	0.6	-0.3	0.8	-0.1	2.1
Mean Putamen Volume	0.7	0.8	2.2	-0.6	1.0	1.5	0.2	-0.2	-1.1	0.9
Fasting Glucose	0.4	0.5	1.2	0.1	0.6	-1.1	1.1	-0.5	0.5	0.2
HbA1C	0.7	0.8	3.0	-1.7	-0.3	-0.5	-0.4	0.7	0.3	-1.3
HDL Cholesterol	1.2	2.0	4.2	2.0	-0.1	1.0	1.1	-1.8	-2.0	0.2
LDL Cholesterol	1.3	2.0	5.0	-1.8	-0.6	-0.0	-2.2	1.7	1.4	0.7
Lupus	0.2	0.3	0.9	1.0	0.1	-0.4	0.4	-0.4	0.0	0.9
Neuroticism (2016)	0.8	1.1	3.1	-1.8	-0.1	-1.1	-1.1	1.2	1.0	-0.1
Primary Biliary Cirrhosis	0.2	0.3	1.8	1.4	0.3	-0.0	0.2	-0.3	-0.3	-0.2
Rheumatoid Arthritis	0.8	1.2	3.8	-0.1	-0.7	-1.2	-0.8	1.1	0.7	1.9
Schizophrenia (2014)	0.3	0.7	2.9	0.8	-0.1	-0.0	0.5	-0.7	-1.7	-0.9
Triglycerides	2.7	4.4	11.3	-1.2	0.2	-1.9	-2.5	2.8	3.4	0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	0.9	0.4	1.0	-0.3	0.6	-0.1	-0.9
Ulcerative Colitis	0.2	0.3	0.6	-0.5	0.1	-0.1	-0.1	0.7	0.6	-0.8
Blood Eosinophil Count	0.5	3.5	11.3	-3.4	-0.2	0.3	-2.3	2.3	1.6	-0.2
Blood Platelet Count	0.0	0.4	1.6	-1.3	-0.4	-0.5	0.4	-0.7	-0.4	0.4
Blood Red Count	0.1	1.4	4.4	-1.5	2.1	0.8	-1.0	0.6	0.2	-1.2
Blood White Count	0.1	1.0	4.5	-2.1	-1.0	0.3	0.1	-0.5	-1.1	-0.3
Heel T-Score	0.3	2.6	8.1	0.4	-2.0	2.8	-1.7	1.0	-0.6	1.2
BMI	0.4	2.5	5.9	-2.0	1.1	-1.1	1.7	-2.4	-1.1	-1.2
Height	0.2	3.9	11.0	3.3	0.1	3.1	-1.4	1.9	1.0	0.2
Waist Hip Ratio (WHR)	0.5	2.3	6.1	-1.9	-0.6	-2.5	-0.8	1.0	1.5	-1.4
Systolic Blood Pressure	0.7	3.3	9.9	-0.7	-1.3	-0.1	-2.5	3.1	2.1	0.8
Smoking Status	0.9	2.0	7.9	-1.4	-0.7	-2.8	-0.2	-0.0	1.3	-1.5
Allergy or Eczema	0.1	0.3	1.0	0.4	-0.1	-0.2	0.2	-0.8	-1.0	-0.3
Cardiovascular Disease	0.5	1.5	2.6	-1.6	0.5	-0.6	-1.0	1.6	1.4	-1.4
Hypothyroidism (self reported)	0.4	0.9	2.3	-0.5	-1.3	0.8	-1.5	0.9	0.2	-0.7
Respiratory disease	0.5	1.0	3.5	-0.4	1.9	-0.7	0.3	-1.0	-0.2	-1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.5	0.5	0.5	-0.1	-0.3	-1.2	-1.2	0.6
Lung FEV1/FVC ratio	1.1	5.8	18.9	-1.3	-2.7	0.3	-4.3	3.0	1.0	1.6
Lung FVC	1.9	9.9	28.8	0.5	-1.4	-0.2	4.6	-5.4	-4.0	-1.2
Neuroticism	1.2	2.9	8.8	-1.1	-1.7	0.1	-3.0	2.0	0.8	1.7
Chronotype (morning person)	0.2	0.6	1.6	0.1	1.2	0.3	-0.4	1.3	0.7	0.2
Hair Pigment	0.0	0.8	2.6	0.3	-0.4	1.3	-0.8	1.6	0.4	-0.7
Tanning	0.0	0.2	0.6	-0.4	-0.8	0.3	-0.2	0.2	-0.4	-0.4
Hand grip strength (left)	0.5	1.3	4.2	2.0	-1.2	-1.1	1.1	-0.2	0.9	0.2
Number of treatments/medications taken	0.6	1.1	3.3	-0.5	1.1	0.2	-1.8	1.2	1.2	-0.1
Average weekly spirits intake	1.3	1.6	4.1	0.3	-0.2	-1.2	1.9	-2.0	-1.1	-0.8
Sensitivity / hurt feelings	0.5	0.9	2.7	-1.6	-0.3	-0.5	-1.4	0.6	0.8	0.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.2	-0.4	0.3	-1.8	-0.8	0.9	1.3	0.8
Hearing difficulty/problems: Yes	2.6	3.9	10.1	-0.8	-0.7	1.0	-2.5	2.7	1.3	3.2
Relative age of first facial hair	1.6	3.3	7.9	-0.4	-2.2	-0.5	-2.5	2.8	2.0	-0.6
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	5.2	-0.9	-0.6	1.3	1.1	-2.0	-2.3	0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.7	3.6	-1.9	0.4	0.7	-0.4	0.4	-0.0	-0.2
Ever had hysterectomy (womb removed)	2.2	2.5	9.5	-0.8	0.0	0.2	-2.0	1.5	0.8	3.1
Systolic blood pressure, automated reading	0.5	1.4	4.8	-0.9	-1.2	0.4	-1.1	2.2	1.0	-0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	-0.6	0.8	0.4	0.2	0.2	0.0	-0.6
Angina	0.5	0.6	1.1	-0.9	-0.6	-0.2	-0.9	1.1	0.9	0.6
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.6	-0.0	-0.6	-0.7	0.6	0.8	-0.1
Vitamin and mineral supplements	0.5	0.7	2.4	0.1	1.6	0.6	1.4	-0.2	-0.1	0.1
Supplements: Zinc	0.3	0.3	0.6	-0.5	0.5	-0.4	0.2	-0.8	-0.7	-0.8
Medication: Co-codamol	0.6	0.7	2.9	-0.1	0.0	-0.5	0.4	0.4	1.0	-1.7
Medication: Metformin	0.5	0.7	1.7	1.3	0.2	-0.3	0.6	-1.1	-1.0	-0.3
Diabetes (father)	1.0	1.2	5.4	-0.3	0.9	-0.2	2.3	-1.2	-0.7	0.4
Diabetes (mother)	0.4	0.6	1.8	-0.3	0.8	-0.3	-1.0	0.4	0.4	1.3
Severe depression (siblings)	1.6	1.8	5.7	0.3	1.9	-0.3	0.7	-1.5	-0.3	-2.4
Pack years adult smoking proportion	0.6	0.9	5.3	-1.0	2.3	0.5	-0.2	0.3	-0.2	-0.1
Impedance of leg (right)	0.1	0.5	1.5	0.5	-0.1	0.5	-0.6	0.9	0.5	-1.2
Leg fat-free mass (left)	0.0	0.1	0.6	-0.2	-0.2	-0.1	-0.1	0.1	0.5	0.8
Trunk fat percentage	0.6	2.6	4.9	-2.2	-0.2	0.5	1.6	-2.0	-1.8	-1.7
Hand grip strength (right)	0.8	2.2	5.2	2.3	-0.8	-0.5	1.9	-2.1	-1.0	0.3
Townsend deprivation index at recruitment	1.1	1.5	5.1	-0.8	2.2	-1.6	-0.2	-0.4	0.8	-1.2
Current tobacco smoking	0.2	0.3	0.7	0.5	0.2	-0.9	-0.0	0.8	0.7	0.4
Average weekly fortified wine intake	0.6	0.7	2.0	-0.4	-0.1	0.5	-1.4	1.1	0.7	-0.9
Maternal smoking around birth	1.8	2.6	6.5	0.3	-0.2	-2.4	2.5	-1.3	-0.8	-1.9
Fed-up feelings	3.5	6.4	12.5	-3.1	0.5	-1.1	-3.5	3.2	3.3	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.8	-1.0	0.7	-0.7	-1.3	1.3	0.9	0.8
Relative age voice broke	1.7	2.6	6.2	0.3	-1.7	-0.6	-1.8	2.2	2.5	0.5
Taking other prescription medications	0.2	0.3	0.9	-0.1	-0.4	0.7	-0.9	0.5	-0.3	-0.5
Age when periods started (menarche)	1.2	3.0	6.7	1.1	-0.5	-2.6	2.0	-2.3	-0.3	-1.9
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	3.2	-1.3	0.8	0.6	-1.8	1.7	1.2	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	4.8	1.6	0.2	1.1	1.1	-1.3	-2.2	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.4	1.2	-0.5	0.3	0.1	-0.1	-0.6	-0.0
Qualifications: CSEs or equivalent	0.9	1.2	1.6	-0.7	-1.1	-0.4	-1.3	1.3	1.3	1.2
Serious illness, injury or assault to yourself	1.6	2.0	4.3	-0.1	-0.6	-0.1	1.7	-2.1	-2.0	-1.6
High blood pressure	0.3	0.9	2.1	-1.1	0.1	-0.5	-0.3	1.4	1.5	-0.6
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.0	-0.5	-0.1	-0.4	-0.4	-0.6	-0.5
Multivitamins +/- minerals	0.3	0.4	1.7	-0.2	-0.8	-0.5	-0.1	-0.5	-0.2	-1.3
Stomach or abdominal pain in last month	0.6	0.8	3.0	-0.7	0.8	-0.8	-0.2	-0.6	-0.0	-1.7
Supplements: Glucosamine	0.6	0.8	1.6	-1.2	0.1	0.6	-0.9	1.3	0.8	0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	-0.2	0.3	-1.2	-0.7	0.4	1.1	0.3
Medication: Atenolol	0.7	0.8	1.5	0.7	-0.2	1.1	-0.8	1.2	0.6	-1.2
Medication: Levothyroxine sodium	0.4	0.7	2.3	-0.3	-1.5	0.8	-1.1	0.7	0.0	-0.3
Sitting height	0.1	0.7	2.4	1.5	0.9	1.2	0.3	0.2	-0.3	0.4
Chronic bronchitis/emphysema (father)	0.7	0.8	3.0	-0.2	-0.4	-0.1	0.9	-1.7	-0.6	-1.2
High blood pressure (mother)	1.3	1.9	5.2	-1.0	-0.7	0.7	-1.8	2.3	1.6	-0.2
Body mass index (BMI)	0.5	2.0	3.8	-1.9	0.5	-0.5	1.7	-1.9	-1.0	-1.4
Impedance of leg (left)	0.1	0.3	0.7	0.6	-0.2	0.8	-0.3	0.7	0.1	-0.8
Leg predicted mass (left)	0.0	0.2	0.8	-0.2	-0.2	-0.1	-0.2	0.2	0.6	0.9
Trunk fat mass	0.4	1.7	3.1	-1.8	0.1	0.5	1.4	-1.7	-1.4	-1.5
Waist circumference	0.4	1.5	7.2	-2.7	0.7	-0.6	0.8	-0.9	-0.4	-1.1
Number of incorrect matches in round	1.0	1.7	5.7	-0.1	-1.5	-1.4	-0.4	1.2	0.7	2.4
Past tobacco smoking	1.2	2.2	7.2	1.1	0.8	2.7	-1.0	1.7	-0.1	1.5
Alcohol usually taken with meals	0.4	0.7	3.7	0.1	-0.4	-0.6	-0.4	0.3	0.6	-1.9
Nervous feelings	0.8	1.4	3.5	-1.0	0.4	-0.8	-1.5	1.1	1.2	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.7	-1.3	0.8	-1.9	-0.6	0.6	0.4	0.7
Hearing difficulty/problems with background noise	1.4	2.2	6.7	-1.4	0.1	1.0	-1.7	1.7	0.6	2.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.2	-0.8	0.4	1.0	-0.8	0.1	-0.8
Had menopause	0.5	0.6	2.0	0.1	-0.2	-0.3	1.4	-0.8	-0.5	-1.1
Had other major operations	0.4	0.5	2.4	-1.6	0.5	-0.3	-0.5	-0.2	0.5	-0.5
Forced vital capacity (FVC)	0.8	3.0	7.0	1.0	-2.6	-0.8	2.3	-2.2	-1.2	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	5.0	2.1	0.7	0.9	1.6	-1.8	-2.2	-1.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	-0.9	0.7	-0.6	0.3	-0.3	0.1	0.5
Qualifications: None of the above	1.1	2.3	7.7	-1.9	2.8	-0.4	-0.1	0.8	1.3	-1.4
Financial difficulties in last 2 years	0.5	0.7	2.4	0.3	1.6	-1.1	0.3	0.1	0.5	-0.9
Mouth/teeth dental problems	1.4	2.2	3.9	-0.8	-0.8	1.0	-1.8	2.0	1.6	1.9
Heart attack	1.1	1.4	3.4	-1.4	1.8	-0.5	-0.2	0.6	1.3	-1.4
Allergy	0.2	0.5	0.8	0.9	-0.8	0.9	-0.4	0.9	0.2	0.8
Pain all over the body in last month	0.3	0.4	1.7	0.3	0.0	-1.3	0.1	0.1	0.5	-0.7
Diabetes (self-reported)	1.0	1.5	4.5	0.4	0.9	1.6	0.3	-1.6	-2.1	-0.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	0.0	-0.0	-1.0	0.5	-0.3	0.2	0.6
Medication: Ramipril	0.7	0.8	3.6	0.0	-0.0	-1.9	0.7	0.3	1.2	-0.3
Medication: Simvastatin	0.4	0.6	2.6	-1.6	0.4	0.6	-0.6	0.1	0.6	-0.2
Fluid intelligence score	0.1	0.2	0.5	-0.1	0.6	0.4	-0.0	-0.7	-0.1	0.5
Illnesses of siblings	1.4	2.0	4.8	1.5	0.5	0.5	-2.2	1.8	1.5	0.9
Neuroticism score	0.9	1.8	3.5	-1.1	-0.7	-1.2	-1.9	1.4	1.3	1.5
Weight	0.1	0.4	1.2	-1.1	0.4	0.1	0.7	-0.5	0.0	-0.8
Impedance of arm (right)	0.1	0.3	1.2	0.1	-0.6	-0.0	-1.1	0.4	0.2	-0.2
Arm fat percentage (right)	0.5	2.1	5.7	-2.4	0.4	-0.1	1.1	-2.0	-1.2	-1.6
Trunk fat-free mass	0.2	1.0	3.0	0.3	0.5	0.2	-0.7	1.6	1.7	0.8
Hip circumference	0.2	0.7	3.1	-1.8	-0.1	0.5	0.8	-0.6	-0.5	-0.3
Time employed in main current job	2.4	2.7	7.2	-1.7	0.2	-1.5	-1.5	2.1	2.7	-0.3
Alcohol intake versus 10 years previously	0.3	0.4	1.3	-1.1	1.1	-0.4	0.2	-0.2	-0.2	-0.2
Father’s age at death	1.7	2.3	5.0	-1.4	0.8	0.7	2.1	-2.2	-2.0	0.2
Worrier / anxious feelings	0.5	0.9	1.6	-1.0	0.9	-1.3	-0.7	0.9	1.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	5.1	-2.0	1.5	-0.3	-2.2	2.2	1.7	0.2
Falls in the last year	0.9	1.2	2.9	0.0	-1.1	1.7	-0.7	0.1	-1.6	1.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.8	0.3	1.3	-0.6	-1.0	0.4	0.1	1.0
Number of live births	0.6	0.8	1.8	-0.9	0.8	0.1	-1.0	1.4	0.8	0.8
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	10.7	0.7	-3.3	-0.7	1.2	-1.6	-1.2	1.0
Pulse rate	1.1	1.9	4.8	-1.7	1.8	-2.2	0.7	0.1	0.9	-1.0
Happiness	0.3	0.3	1.2	-0.1	-1.1	0.3	0.5	-0.5	-0.4	0.4
Noisy workplace	0.8	0.9	3.1	0.7	0.4	1.8	-1.5	0.5	-0.4	0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.5	2.1	-1.3	-0.6	0.7	-1.1	-0.2	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	-0.1	0.5	0.1	1.0	-0.7	-1.2	1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	3.1	0.7	0.9	0.6	1.0	-1.8	-1.8	0.9
Asthma	0.3	0.6	1.1	-0.7	0.7	-0.9	0.3	-0.9	-0.5	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.1	0.3	0.6	0.3	-1.5	0.1	0.1	-1.2
Medication: Cholesterol lowering	0.5	0.8	1.6	-1.2	0.8	-0.3	-0.9	1.0	0.9	-0.7
Depression (self-reported)	0.3	0.3	0.9	-0.5	1.0	-0.0	-0.3	0.5	0.8	0.4
Medication: Lansoprazole	1.1	1.3	4.4	0.3	0.1	1.8	0.2	-1.0	-2.1	-0.1
Prospective memory result	2.0	2.5	7.8	0.4	-0.6	-0.4	-2.8	2.3	1.9	0.4
Lung cancer (father)	0.3	0.4	1.3	-0.4	-1.2	-0.5	-0.8	-0.4	-0.6	-0.1
Illnesses of mother	0.8	1.0	3.2	-0.1	0.3	0.2	1.2	-1.8	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	11.6	-0.8	-3.4	-1.4	0.4	-0.7	-0.0	0.9
Pulse wave Arterial Stiffness index	1.8	2.1	4.2	-1.0	1.5	0.5	-2.0	2.0	1.3	1.1
Impedance of arm (left)	0.1	0.3	0.9	0.1	-0.9	-0.4	-1.0	0.3	-0.0	-0.6
Arm fat mass (right)	0.3	1.2	3.1	-1.8	0.3	-0.0	1.1	-1.6	-0.8	-1.1
Trunk predicted mass	0.2	1.2	3.3	0.3	0.5	0.2	-0.8	1.7	1.8	0.9
Standing height	0.3	3.0	6.8	1.6	-0.3	1.1	-1.9	2.6	2.1	1.2
Length of working week for main job	0.4	0.5	1.7	-0.2	-0.3	0.5	0.6	-0.8	-1.3	0.2
Exposure to tobacco smoke at home	1.1	1.2	2.6	-1.3	0.9	-1.3	-0.8	0.6	1.6	-1.1
Breastfed as a baby	0.7	0.9	2.3	-0.6	-0.5	-1.5	1.3	-0.6	0.6	-0.8
Tense / ‘highly strung’	1.2	2.0	5.6	-0.9	0.0	-1.9	-1.6	0.8	1.1	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.2	0.4	1.5	-1.3	0.9	-0.4	0.4	0.4
Hair/balding pattern: Pattern 4	0.4	1.0	4.0	0.3	2.0	-0.2	1.3	-1.2	-0.2	0.2
Birth weight of first child	0.7	1.2	3.3	-0.6	-1.8	1.1	-0.8	-0.6	-1.4	0.8
Peak expiratory flow (PEF)	0.7	1.6	4.4	-0.5	-2.1	-0.7	0.5	-1.6	-1.6	0.9
Pulse wave reflection index	0.7	0.8	1.6	-0.5	0.5	1.2	-1.2	0.8	0.0	1.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.1	0.6	-0.3	-0.1	-0.1	0.1	0.6
Loud music exposure frequency	0.3	0.3	0.6	0.7	0.5	-0.5	0.5	-0.8	0.1	-0.8
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	6.2	1.7	-1.3	1.0	1.5	-2.3	-2.5	1.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	6.2	0.0	1.4	-0.1	0.9	0.2	-0.0	-2.5
Blood clot in the leg (DVT)	0.2	0.3	0.6	0.1	0.8	-0.3	-0.8	0.3	0.7	-0.0
Medication: Paracetamol	0.6	1.1	2.5	0.4	-1.3	0.4	-1.6	0.9	0.8	1.1
Headache pain in last month	0.7	1.3	2.0	-1.3	-0.7	0.3	-1.2	1.4	1.4	1.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.2	0.4	-0.2	-0.7	1.0	-1.1	-0.6	0.9
Glaucoma (self-reported)	1.6	1.9	5.1	1.7	0.1	-1.0	2.3	-1.5	-0.9	-0.8
Gout (self-reported)	1.4	2.0	5.2	1.8	0.4	1.0	1.1	-1.3	-2.3	-1.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.5	-0.2	-0.8	1.6	-1.4	0.7	-0.2	-0.4
Medication: Amlodipine	0.3	0.4	0.7	-0.3	0.4	0.6	0.8	0.8	0.5	-0.8
Medication: Ventolin 100micrograms inhaler	1.3	1.6	3.1	-1.3	0.5	0.8	-1.6	1.8	1.0	1.4
Birth weight	0.3	0.7	2.4	-1.6	0.3	-0.3	1.0	-0.7	-0.4	0.6
Chronic bronchitis/emphysema (mother)	0.6	0.8	1.9	0.5	-0.7	-1.2	-0.3	0.8	1.4	0.6
High blood pressure (siblings)	0.9	1.2	2.2	-0.7	-1.1	-0.9	1.5	-1.2	-0.7	-1.5
Forced vital capacity (FVC), Best measure	0.7	2.5	6.4	0.1	-2.5	-1.3	2.0	-2.1	-0.9	0.2
Body fat percentage	0.9	3.4	5.9	-2.4	0.2	0.5	1.8	-2.3	-2.0	-2.3
Leg fat percentage (right)	1.0	3.5	7.0	-2.6	1.0	0.3	1.8	-1.9	-1.5	-2.6
Arm fat-free mass (right)	0.1	0.3	0.8	0.3	-0.2	0.3	0.0	0.8	0.9	0.5
Exposure to tobacco smoke outside home	0.4	0.5	2.1	-0.3	1.1	-0.2	-0.1	0.3	0.4	-1.4
Comparative body size at age 10	1.2	3.3	7.5	-0.7	-2.1	-0.5	2.5	-2.7	-1.9	-0.7
Number of full brothers	2.4	3.0	7.1	0.8	-1.9	-2.1	2.7	-1.9	-0.9	-0.9
Worry too long after embarrassment	0.4	0.6	1.6	0.4	-0.5	-0.6	0.3	-1.2	-1.3	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.9	-1.0	0.8	0.9	-0.1	-0.9	-0.4	0.9
Wheeze or whistling in the chest in last year	0.6	1.0	6.0	-2.4	-0.1	-0.5	-0.8	0.1	0.2	0.0
Number of children fathered	0.9	1.1	2.3	-1.1	1.0	-0.8	-0.8	1.1	1.5	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.9	-0.7	-1.4	-0.1	-0.4	0.5	0.6	-0.1
Age at first live birth	0.8	1.4	3.1	1.7	-1.1	-0.5	-0.2	0.1	1.7	1.5
Pulse wave peak to peak time	1.3	1.6	3.2	1.1	-1.5	-0.3	1.6	-1.8	-1.1	-0.8
Health satisfaction	1.0	1.3	3.8	-0.7	-1.8	-1.9	-0.8	-0.1	1.0	0.2
Shortness of breath walking on level ground	2.5	3.0	8.8	-3.0	1.1	-1.0	-0.5	1.4	1.9	-2.0
Qualifications: College or University degree	0.3	0.9	2.9	-0.2	-0.8	-0.9	-1.1	-0.0	0.8	1.7
Eye problems/disorders: None of the above	1.3	1.6	4.3	-0.4	0.2	-0.3	0.8	-2.1	-1.2	-2.1
Mouth/teeth dental problems: Loose teeth	1.8	2.2	3.9	1.2	2.0	0.3	1.5	-1.3	-1.4	-2.0
Emphysema/chronic bronchitis	1.6	1.8	3.5	1.1	1.9	-0.4	1.3	-1.7	-0.7	-1.6
Medication for pain relief, constipation, heartburn	0.9	1.6	7.1	-0.2	0.5	-1.3	2.7	-1.4	0.1	0.3
Neck or shoulder pain in last month	0.9	1.3	4.5	-1.7	-2.1	0.2	-0.2	0.4	0.0	1.2
Medication: Blood pressure	0.3	0.5	2.9	-0.1	-0.2	-0.1	-0.3	0.6	0.6	-1.7
Angina (self-reported)	0.5	0.7	1.6	-0.8	-0.5	0.1	-1.0	1.3	1.0	0.5
Migraine (self-reported)	0.6	0.7	2.0	1.4	-0.0	0.7	0.6	-0.4	-0.9	-1.0
Medication: Ibuprofen	0.4	0.5	2.0	0.1	-0.1	0.9	-1.4	-0.1	-0.7	-0.6
Medication: Allopurinol	1.5	2.0	5.7	0.9	1.0	2.1	0.7	-0.8	-2.4	-0.9
Medication: Omeprazole	1.0	1.2	2.1	-1.0	-1.4	1.4	-1.1	0.6	-0.7	1.1
Medication: Seretide 50 evohaler	0.2	0.3	0.7	-0.0	0.6	0.9	0.0	-0.3	-0.8	-0.3
Mean time to correctly identify matches	0.1	0.2	0.6	0.7	0.3	-0.1	-0.1	0.7	0.5	0.3
Heart disease (mother)	0.6	0.7	2.0	-0.6	1.4	-0.9	1.1	-0.0	0.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	3.2	-1.8	0.2	0.1	-1.0	0.6	0.8	-0.2
Whole body fat mass	0.5	2.0	3.8	-1.8	0.2	0.4	1.5	-1.9	-1.5	-1.6
Leg fat mass (right)	0.6	2.3	4.0	-2.0	0.7	0.2	1.6	-1.9	-1.3	-1.8
Arm predicted mass (right)	0.0	0.2	0.5	0.4	0.0	0.4	0.0	0.6	0.7	0.6
Pulse rate, automated reading	0.5	1.6	4.0	-2.0	1.9	-1.1	1.3	-0.3	-0.1	-0.5
Alcohol intake frequency.	0.5	1.1	2.0	-1.4	1.3	0.3	-1.4	1.4	0.6	0.2
Comparative height size at age 10	0.7	3.7	10.3	1.0	0.2	1.5	-2.5	3.2	2.3	0.9
Number of full sisters	1.1	1.3	3.5	-0.7	1.9	1.4	0.1	-0.6	-1.4	0.8
Suffer from ‘nerves’	0.7	1.1	3.0	-1.0	-0.1	-1.7	-0.8	0.8	1.2	1.1
Overall health rating	1.1	2.3	9.0	-3.0	1.1	-0.7	-1.3	0.9	1.5	-0.7
Chest pain or discomfort	0.6	0.9	1.9	0.4	-1.2	-1.4	0.3	-1.2	-0.4	-1.2
Had major operations	1.2	1.4	2.8	1.4	1.4	0.1	-0.8	1.2	0.9	-1.7
Age at last live birth	0.4	0.6	1.8	0.1	0.4	0.2	-0.5	1.1	1.0	1.4
Family relationship satisfaction	0.4	0.5	1.5	0.1	1.2	-1.2	0.6	-0.5	0.3	-0.1
Leg pain on walking	0.4	0.5	1.1	-1.0	0.5	-0.3	-0.6	0.4	1.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.7	-0.2	0.4	-0.6	-0.7	0.6	0.6	-1.3
Commuting to job workplace: Car/motor vehicle	1.1	1.3	4.2	-1.9	-0.1	2.1	-0.6	0.3	-0.7	0.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.8	0.1	0.1	-0.5	-1.1	1.4	2.2	-0.2
Medication: Aspirin	0.8	1.0	4.4	-0.6	-0.3	-1.5	0.2	-0.4	0.3	-2.1
Supplements: Vitamin C	1.7	2.0	5.9	-0.4	-0.4	-0.5	-2.2	2.4	1.5	0.7
Knee pain experienced in last month	0.5	0.8	3.2	-1.8	0.9	0.3	-1.1	0.5	-0.0	-0.1
Hypertension (Self-reported)	0.4	1.0	3.2	-0.7	0.3	-0.6	-0.3	1.7	1.8	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	3.9	-0.3	-1.5	1.8	-2.0	0.9	-0.4	1.5
Illnesses of father: Heart disease	1.5	2.1	9.1	-3.0	0.9	-1.4	-0.5	0.7	1.3	0.6
Illnesses of siblings: Diabetes	1.3	1.6	5.1	-1.6	2.3	-0.2	-1.1	0.8	0.6	1.1
Smoking status: Previous	1.1	1.7	3.6	-1.6	-0.3	-1.7	0.5	-1.6	-0.0	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.1	13.7	-0.9	-0.9	-0.6	-2.5	3.7	2.8	2.4
Whole body fat-free mass	0.1	0.5	1.4	0.2	0.1	0.2	-0.4	1.0	1.2	0.9
Leg fat-free mass (right)	0.1	0.3	1.5	0.1	-0.5	0.0	-0.3	0.2	0.5	1.2
Arm fat percentage (left)	0.6	2.5	6.2	-2.5	0.2	-0.2	1.2	-2.2	-1.4	-1.6
Average weekly red wine intake	1.6	2.4	6.3	-0.7	-0.5	0.8	1.8	-2.5	-2.3	-0.6
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.1	1.8	-0.2	-0.9	1.7	-0.8	0.0	-0.4
Mood swings	1.3	2.3	6.8	-0.8	-0.7	-1.1	-1.7	2.6	2.0	0.3
Loneliness, isolation	0.3	0.4	1.1	-1.0	-0.0	-0.7	0.1	-0.2	0.1	1.0
Long-standing illness, disability or infirmity	0.4	0.7	1.3	-0.3	1.1	1.1	-1.1	-0.4	-0.2	-0.8
Ever had bowel cancer screening	1.2	1.4	2.6	-1.4	1.0	1.6	-0.3	-0.6	-1.6	-1.2
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.0	0.8	0.3	-0.4	-0.6	-0.8	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.3	-1.5	0.4	-0.5	0.6	-0.7	0.8	0.9
Friendships satisfaction	0.6	0.8	3.6	0.5	-0.5	-0.8	1.9	-0.8	-0.4	0.1
Qualifications: nursing, teaching	0.4	0.7	1.3	0.2	-1.0	0.9	-1.1	1.0	0.2	0.9
Commuting to job workplace: Walk	0.7	0.8	1.8	1.2	-0.7	-1.3	0.8	-0.7	-0.1	0.8
Eye problems/disorders: Cataract	2.9	3.3	8.2	0.4	-1.0	1.0	-2.5	2.9	1.4	2.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	0.0	-0.6	-0.7	0.7	-1.1	-0.5	-1.0
Medication for cholesterol	1.2	1.8	3.4	1.1	1.3	0.9	1.6	-1.8	-1.9	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.5	-1.1	-0.1	-0.1	-0.9	1.2	-0.0	-0.4
Back pain experienced in last month	1.7	2.5	6.5	0.3	-0.9	-1.7	2.5	-2.2	-0.9	-1.3
Mineral and other dietary supplements	1.8	2.5	4.2	1.7	1.3	-0.5	1.9	-2.0	-1.7	-1.4
Breast cancer (self-reported)	2.2	2.6	7.1	1.8	1.1	1.0	1.7	-1.2	-1.1	-2.7
Asthma (self-reported)	0.3	0.6	1.0	-0.9	0.6	-0.9	0.4	-1.0	-0.6	-1.0
Osteoporosis (self-reported)	0.6	0.7	4.1	2.0	-0.4	-0.3	0.7	-0.2	-0.2	-0.1
Osteoarthritis (self-reported)	0.3	0.4	1.6	-1.3	0.7	-0.2	0.1	0.1	0.6	-0.4
Medication: Aspirin	0.4	0.5	2.0	-0.2	-0.3	-1.1	-0.2	-0.2	0.3	-1.4
Medication: Gliclazide	2.2	2.5	5.0	-2.2	-0.7	-0.7	-2.0	1.8	1.6	1.3
Illnesses of father: None of the above (group 1)	2.0	2.4	7.0	2.6	-1.4	2.5	-0.8	0.6	-0.8	0.6
Smoking status: Current	0.2	0.4	1.1	0.2	0.4	-1.0	0.2	0.8	0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	6.6	-0.7	-2.6	-1.0	-0.1	-0.4	0.1	-0.5
Whole body water mass	0.1	0.6	1.5	0.2	0.1	0.3	-0.6	1.1	1.2	1.0
Leg predicted mass (right)	0.1	0.3	1.5	0.1	-0.6	-0.0	-0.3	0.2	0.5	1.2
Arm fat mass (left)	0.3	1.1	3.2	-1.8	0.3	-0.0	0.9	-1.4	-0.7	-1.0
Number of self-reported non-cancer illnesses	1.3	2.3	3.7	-1.9	1.9	1.7	-1.8	1.5	0.8	0.2
Average weekly champagne plus white wine intake	0.5	0.7	2.0	1.4	-0.3	0.9	-0.7	0.4	0.3	-0.9
Miserableness	1.5	2.6	7.4	-0.9	-1.0	-1.4	-1.5	2.7	2.2	-0.2
Guilty feelings	0.6	0.9	2.4	-0.3	-0.4	-0.4	1.0	-1.4	-1.6	-0.4
Wears glasses or contact lenses	0.4	0.4	1.5	-0.1	0.8	-0.5	1.2	-0.4	0.2	-0.7
Ever taken oral contraceptive pill	1.4	1.5	4.5	-0.0	0.1	0.3	1.5	-1.9	-2.1	-0.3
Hearing aid user	2.2	2.4	7.6	-1.4	0.8	2.3	-0.8	0.6	-0.7	2.8
Mother’s age at death	2.1	2.6	10.4	-0.9	0.2	2.2	1.0	-1.1	-3.2	0.1
Financial situation satisfaction	0.1	0.1	0.4	0.3	0.6	0.3	-0.3	0.2	0.5	0.3
Tinnitus: Yes, now most or all of the time	1.4	1.7	5.8	-1.5	-0.0	0.8	-1.7	0.4	0.1	2.4
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.7	-0.4	-0.7	0.3	-0.9	-0.1	-0.4
Eye problems/disorders: Glaucoma	1.1	1.3	4.3	1.6	0.3	-0.9	2.1	-0.8	-0.5	0.2
Medication: Blood pressure	0.9	1.8	4.1	-1.0	-1.0	-0.6	-1.5	1.8	2.0	0.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.6	-1.6	0.5	1.1	-0.7	1.0	0.0	-1.1
Supplements: Fish oil (including cod liver oil)	3.1	4.0	7.2	-2.4	-1.6	-0.3	-2.1	2.3	2.7	1.5
High cholesterol (Self-reported)	0.7	1.2	5.2	-2.3	0.4	0.3	-1.0	0.8	0.5	-1.2
Medication: Bendroflumethiazide	0.3	0.5	2.6	-0.5	-0.3	-0.6	-0.2	0.5	0.4	-1.6
Medication: Paracetamol	0.4	0.6	2.1	0.9	-1.4	0.9	-0.4	-0.2	-0.2	0.6
Medication: Lisinopril	1.5	1.9	5.2	-0.1	-1.8	0.4	-2.3	1.8	1.2	0.7
Medication: Atorvastatin	1.7	2.1	3.6	-1.9	1.5	-1.5	-1.3	1.7	1.4	-0.1
Illnesses of father: High blood pressure	1.0	1.3	6.5	-2.5	-0.2	-0.6	-0.1	1.2	0.6	-0.3
Alcohol drinker status: Never	0.5	0.5	1.6	-0.9	0.4	1.2	0.3	-0.1	-0.7	-0.9
Ever smoked	0.9	1.6	5.7	-0.1	-0.8	-2.4	1.1	-1.5	-0.0	-1.1
Basal metabolic rate	0.0	0.2	0.8	-0.1	0.0	0.3	-0.2	0.7	0.9	0.5
Leg fat percentage (left)	1.0	3.7	6.4	-2.5	0.9	0.4	2.1	-2.2	-1.9	-2.4
Arm fat-free mass (left)	0.1	0.5	1.3	-0.1	-0.2	0.2	-0.3	1.1	1.1	0.8
Number of operations (self-reported)	2.0	3.0	8.6	-0.9	0.8	1.3	-2.9	2.4	1.8	0.8
Average weekly beer plus cider intake	1.4	2.1	4.8	-0.7	0.5	-1.5	-1.0	1.1	2.1	2.2
Irritability	0.3	0.6	0.8	-0.7	0.5	-0.8	-0.9	0.8	0.9	0.8
Risk taking	1.0	1.5	4.6	-0.0	-0.6	1.4	-2.1	1.5	-0.1	-1.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.9	-0.2	0.3	0.6	-0.1	-1.0	-0.7	0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.6	0.7	-0.4	0.0	0.2	0.4	-0.1	0.2
Age started oral contraceptive pill	0.5	0.6	1.5	0.6	0.4	1.2	-0.9	1.1	0.2	0.1
Diastolic blood pressure, automated reading	0.3	1.0	3.0	-0.9	-1.6	-0.1	-0.0	1.7	0.7	-0.3
Ever depressed for a whole week	0.2	0.2	0.5	0.7	0.3	-0.4	0.4	-0.7	-0.3	-0.5
Unable to work because of sickness or disability	0.5	0.7	2.6	-0.9	0.0	-0.5	0.7	-1.6	-0.5	0.4
Commuting to job workplace: Cycle	0.5	0.6	0.9	0.1	0.8	0.6	-0.9	0.9	0.6	-0.9
Myopia	3.9	5.6	12.4	1.1	1.4	-2.3	3.5	-3.5	-1.8	-1.7
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.6	1.4	-0.9	0.4	0.7	-1.8	-1.9	1.1
Cholesterol lowering medication	0.4	0.6	2.4	-1.6	-0.5	-0.5	-0.5	0.3	0.8	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.9	-1.5	-1.7	1.3	-1.3	0.3	-0.9	0.8
Pain experienced in last month	0.3	0.6	3.5	1.9	0.3	0.2	0.3	-0.1	-0.3	0.3
Supplements: Calcium	1.2	1.3	3.4	-0.8	-0.1	1.4	1.4	-0.9	-1.9	0.5
Basal cell carcinoma (self-reported)	0.8	0.9	2.6	0.8	-0.8	-1.6	0.8	-1.2	-0.6	-0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.3	-1.2	1.8	-0.5	-0.4	0.6	1.3	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	-0.0	0.9	-0.5	-0.7	0.3	0.7	-0.3
Heart disease (siblings)	1.5	1.9	5.4	-0.7	-2.3	-0.6	1.6	-1.4	-1.0	-1.0
Alcohol drinker status: Previous	0.8	0.9	1.9	-0.9	1.4	-0.6	-0.8	1.2	0.9	-0.3
Pack years of smoking	0.8	1.1	5.2	-0.8	2.3	1.0	0.1	-0.3	-0.8	-0.5
Impedance of whole body	0.1	0.3	0.9	0.4	-0.9	0.2	-0.7	0.6	-0.1	-0.7
Leg fat mass (left)	0.6	2.3	4.3	-1.9	0.6	0.3	1.7	-2.1	-1.5	-1.6
Arm predicted mass (left)	0.1	0.4	1.2	-0.0	0.1	0.4	-0.3	1.1	1.1	0.6