Hub : Genes

COLCA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1430 0.0480 4.5e-04 0.053 NA 0.066 NA 0.083 3.7e-05 NA 4.6e-06 NA 2.5e-07
2 GTEx Artery Aorta 0.1320 0.0510 5.3e-03 -0.005 NA 0.016 NA -0.005 8.1e-01 NA 4.1e-02 NA 8.0e-01
3 GTEx Cells EBV-transformed lymphocytes 0.4120 0.0840 1.5e-05 0.312 NA 0.266 NA 0.291 7.9e-11 NA 2.9e-09 NA 4.3e-10
4 GTEx Colon Transverse 0.4180 0.0640 2.6e-12 0.290 NA 0.277 NA 0.292 3.0e-14 NA 1.4e-13 NA 2.4e-14
5 GTEx Esophagus Muscularis 0.0870 0.0360 5.4e-03 0.045 NA 0.035 NA 0.038 9.5e-04 NA 3.3e-03 NA 2.2e-03
6 GTEx Nerve Tibial 0.1824 0.0563 3.0e-04 0.035 NA 0.028 NA 0.032 1.5e-03 NA 4.4e-03 NA 2.3e-03
7 GTEx Spleen 0.3330 0.1240 7.0e-03 0.224 NA 0.225 NA 0.217 2.0e-06 NA 1.8e-06 NA 2.9e-06
8 METSIM Adipose 0.0758 0.0250 9.2e-06 0.005 0.031 0.016 0.033 0.018 5.7e-02 1.4e-05 1.4e-03 9.6e-06 9.0e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.6 0.9 2.7 -0.3 0.1 -0.4 -1.6 -0.6 1.4 -0.8 1.1
Bipolar Disorder or Schizophrenia 0.6 1.3 2.7 0.9 0.6 -1.4 -1.4 0.1 1.6 -1.6 0.6
Depressed Affect (Nagel 2018) 0.2 0.5 1.6 -0.2 0.3 0.1 1.1 -0.0 -0.6 0.6 1.3
Depression (Nagel 2018) 0.4 0.6 1.4 -0.9 -0.8 0.5 -0.0 -1.2 -0.6 1.0 -0.3
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.9 -0.5 -0.6 0.7 1.4 -0.9 -0.5 0.7 0.1
Neuroticism (Nagel 2018) 0.3 0.8 1.7 -0.9 -0.0 0.6 1.3 -1.0 -0.9 0.9 0.8
Schizophrenia (2018) 0.5 1.0 2.3 1.4 0.7 -1.4 -0.5 0.6 1.0 -1.5 -0.1
Schizophrenia vs Biploar Disorder 1.0 1.3 3.4 1.4 1.4 -0.5 -1.2 1.8 0.8 -0.6 0.8
Worry (Nagel 2018) 1.2 2.6 4.3 -1.6 -1.5 1.3 1.8 -1.8 -2.1 1.6 -0.8
Alzheimer’s Disease (in mother) 0.9 1.1 3.3 1.5 0.5 -1.8 -0.4 0.7 0.6 -1.3 0.3
Alzheimer’s Disease (in father) 1.3 1.4 3.7 -1.5 0.4 1.0 0.8 -1.5 -0.4 1.0 -1.9
Alzheimer’s Disease (including proxy) 0.3 0.4 1.8 -0.8 -0.1 0.2 0.1 -0.5 -0.2 0.6 -1.4
Crohns Disease (2017) 0.2 0.5 1.2 0.3 1.1 -0.5 -0.9 0.2 1.0 -0.3 0.8
Irritable Bowel Disease (IBD) 0.5 1.3 2.3 1.5 0.8 -1.3 -0.6 1.2 1.0 -0.7 1.4
Ulcerative Colitis (UC) 1.1 2.0 4.1 2.0 0.8 -1.6 -0.6 1.8 0.9 -1.0 1.8
Major Depression (MDD) 0.5 0.6 1.0 0.5 0.6 -1.0 -1.0 -0.3 0.9 -0.9 0.8
Reaction Time 0.7 1.2 2.5 -1.3 -1.3 1.6 0.1 -0.9 -0.6 1.6 0.4
Verbal and Numeric Reasoning (VNR) 0.2 0.6 3.3 0.2 -0.7 0.1 1.8 -0.4 -0.6 0.5 -0.3
Breast Cancer 1.2 2.8 6.9 -1.4 -0.2 1.4 2.6 -1.2 -2.6 1.2 1.3
Ovarian Cancer 0.3 0.3 1.0 0.4 0.9 -0.0 -1.0 0.5 0.2 -0.1 0.6
Prostate Cancer 0.1 0.1 0.6 -0.2 -0.8 -0.2 -0.0 -0.0 0.0 -0.1 0.7
Age at First Birth 0.3 0.4 1.5 -0.5 -0.7 0.5 -0.1 -0.6 -0.0 0.4 -1.2
Bipolar Disorder (2011) 0.2 0.2 0.6 -0.3 -0.8 0.1 -0.4 -0.4 0.1 -0.4 -0.2
Body Mass Index (BMI) (2010) 2.0 2.8 4.2 -1.6 -1.9 1.9 1.3 -1.3 -1.8 2.0 -1.4
Coronary Artery Disease (CAD) 2.1 2.5 6.0 2.4 -0.6 -2.1 -0.3 1.8 0.2 -1.2 2.0
Crohns Disease (2012) 1.3 2.2 7.2 0.4 1.9 -0.3 -2.7 1.0 1.9 -0.2 1.3
Mean Putamen Volume 0.2 0.3 0.8 0.4 -0.9 -0.6 0.0 0.2 0.0 -0.4 -0.9
Fasting Glucose 0.7 0.8 3.9 0.0 0.5 -0.4 2.0 -0.7 -1.4 -0.1 0.4
HbA1C 1.4 1.5 6.3 0.4 0.3 -0.3 2.5 0.2 -1.9 0.0 1.4
HDL Cholesterol 0.3 0.6 0.9 -0.9 0.8 0.7 0.6 -0.9 -0.9 0.6 0.1
LDL Cholesterol 3.2 5.1 8.5 2.9 0.8 -2.5 -1.5 2.7 2.4 -2.8 1.5
Lupus 1.8 2.7 5.1 2.1 1.0 -2.0 -0.4 1.7 1.0 -2.3 1.7
Neuroticism (2016) 0.1 0.2 0.8 0.2 -0.0 -0.0 0.3 0.3 -0.1 0.4 0.9
Primary Biliary Cirrhosis 0.9 1.3 4.2 -1.2 -2.1 1.1 0.3 -1.2 0.3 1.2 -0.6
Rheumatoid Arthritis 0.4 0.5 1.2 0.3 0.3 -1.0 -0.1 -1.1 0.8 -0.5 -0.8
Schizophrenia (2014) 0.4 1.0 2.3 0.8 0.7 -1.0 -1.5 -0.1 1.5 -1.1 0.2
Triglycerides 0.8 1.2 2.5 1.6 0.3 -1.4 -0.1 1.2 1.4 -1.3 -0.6
Type 2 Diabetes (T2D) (2012) 1.5 1.7 3.1 -0.3 -1.6 1.6 1.2 0.6 -1.4 1.8 -1.4
Ulcerative Colitis 0.8 1.2 2.1 1.4 0.7 -1.3 -0.8 1.3 0.7 -0.8 1.3
Blood Eosinophil Count 1.0 7.9 20.1 3.1 3.1 -3.3 -0.9 1.8 -0.1 -3.2 4.5
Blood Platelet Count 0.2 2.8 5.5 -1.6 -0.6 1.6 1.6 -1.5 -2.4 1.2 -2.2
Blood Red Count 0.8 7.9 28.8 0.9 -1.9 -2.6 -3.6 -1.1 5.4 -2.4 -1.8
Blood White Count 0.2 1.1 4.9 -0.3 -0.7 0.0 1.3 -0.7 -1.1 0.2 -2.2
Heel T-Score 0.5 3.8 8.6 2.8 -0.7 -2.5 -0.8 1.5 1.4 -2.9 1.4
BMI 0.1 0.4 2.0 -0.3 -0.8 0.3 -0.6 -0.1 0.6 0.3 -1.4
Height 0.2 4.7 16.6 1.2 0.4 -2.1 -3.2 0.3 4.1 -2.1 -0.5
Waist Hip Ratio (WHR) 1.3 5.8 13.5 2.9 -0.5 -3.7 -1.9 1.8 3.0 -2.7 1.2
Systolic Blood Pressure 0.4 2.2 8.5 -1.2 -2.9 1.7 -0.9 -0.6 -0.4 1.9 -0.2
Smoking Status 1.4 3.4 8.9 2.3 1.7 -3.0 0.2 0.8 0.4 -3.0 -0.7
Allergy or Eczema 0.4 1.0 2.1 -0.1 -0.1 -0.6 1.4 -1.1 -1.3 -0.6 -1.5
Cardiovascular Disease 0.7 2.4 5.9 -1.6 -2.3 2.0 -0.8 -1.0 0.0 2.4 -0.4
Hypothyroidism (self reported) 1.8 4.1 5.7 -2.3 -0.9 2.3 2.2 -2.4 -2.0 2.3 -1.0
Respiratory disease 0.5 1.1 2.8 0.5 0.7 -1.6 0.8 -1.1 -1.0 -1.7 -0.1
Type 2 Diabetes (T2D) (2018) 0.9 1.7 5.1 -0.8 1.2 0.1 1.9 -1.4 -2.3 0.1 -0.3
Lung FEV1/FVC ratio 0.1 0.4 1.6 0.5 -0.9 -0.1 -0.6 1.3 0.6 -0.2 0.0
Lung FVC 0.1 0.5 1.0 0.8 -0.2 -0.9 -0.5 1.0 0.9 -0.7 0.6
Neuroticism 0.2 0.5 2.7 0.1 0.8 -0.3 0.9 0.0 0.1 -0.0 1.6
Chronotype (morning person) 0.2 0.4 1.4 -0.7 -0.1 0.3 -0.1 -1.2 -0.1 0.4 1.0
Hair Pigment 0.0 0.8 2.3 -0.2 -1.4 0.4 1.2 -0.5 -1.5 0.4 -0.1
Tanning 0.1 1.2 3.7 0.2 1.3 -0.2 -1.9 0.3 1.5 -0.3 1.1
Hand grip strength (left) 0.5 1.4 5.1 0.3 -0.1 -0.6 -2.3 -0.3 2.1 -0.8 -0.5
Number of treatments/medications taken 0.2 0.4 1.8 0.6 -1.3 -0.7 -0.2 0.4 -0.2 -0.2 -0.1
Average weekly spirits intake 0.8 1.0 2.3 1.5 0.0 -1.1 -0.7 1.5 0.6 -1.0 0.5
Sensitivity / hurt feelings 0.8 1.4 7.6 0.4 2.8 -0.5 0.8 0.2 0.1 -0.3 1.5
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.5 -0.4 -0.6 -0.2 -0.2 -0.7 -0.7 0.2 -0.1
Hearing difficulty/problems: Yes 0.9 1.3 5.5 0.7 2.3 -0.6 1.1 0.7 -0.2 -0.1 1.5
Relative age of first facial hair 0.4 0.8 2.6 -0.6 1.6 -0.1 -0.1 -1.5 -0.8 0.5 0.8
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 -0.3 -0.5 -0.0 -0.5 -0.4 -0.2 0.0 0.4
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.3 0.5 0.6 -0.3 -0.3 0.2 -0.3 0.0 -0.1
Ever had hysterectomy (womb removed) 0.3 0.3 1.2 -0.2 0.1 0.2 0.5 -0.2 -1.1 0.1 -1.1
Systolic blood pressure, automated reading 0.4 1.2 4.1 -0.9 -2.0 0.9 0.2 -0.9 -0.7 1.2 -0.8
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 7.0 1.7 1.2 -0.9 -1.1 2.6 1.2 -1.1 0.7
Angina 0.9 1.2 4.9 -1.2 2.2 0.5 -0.9 -1.2 -0.3 0.6 0.3
Medication for hormone replacement therapy 0.4 0.5 1.9 0.2 0.5 -0.3 -1.4 0.3 0.7 -0.5 0.8
Vitamin and mineral supplements 0.4 0.5 1.2 0.3 -0.5 0.3 -1.0 1.1 0.8 0.8 -0.5
Supplements: Zinc 0.5 0.6 1.7 -0.8 -0.5 1.3 0.0 0.0 0.6 1.3 -0.0
Medication: Co-codamol 1.2 1.4 3.4 -1.0 -1.1 0.7 1.8 -1.0 -1.6 0.6 -1.0
Medication: Metformin 0.8 1.2 1.9 1.1 1.4 -1.2 -0.9 1.1 0.4 -1.0 1.4
Diabetes (father) 0.4 0.6 1.6 -0.5 1.2 0.8 0.6 0.1 -0.6 0.8 0.9
Diabetes (mother) 0.6 0.8 2.4 -0.5 0.5 -0.0 1.6 -1.1 -1.3 0.2 -0.7
Severe depression (siblings) 0.8 0.8 3.0 -0.7 -1.7 0.9 -0.7 -0.3 0.6 0.9 -0.8
Pack years adult smoking proportion 0.4 0.6 2.8 0.4 1.7 -0.7 -1.0 0.2 0.4 -0.5 0.5
Impedance of leg (right) 1.1 5.3 11.1 -3.3 -1.6 3.0 1.0 -2.7 -1.6 2.7 -1.4
Leg fat-free mass (left) 0.4 2.2 5.3 1.6 0.3 -1.5 -1.8 1.5 2.3 -1.5 -0.3
Trunk fat percentage 0.1 0.5 1.3 -0.4 -1.1 -0.3 -0.5 -0.7 0.5 -0.4 -1.1
Hand grip strength (right) 0.2 0.6 1.9 -0.1 -0.1 -0.2 -1.4 -0.8 1.0 -0.3 -0.8
Townsend deprivation index at recruitment 0.3 0.4 1.6 0.2 1.3 -0.4 -0.8 -0.0 0.7 -0.2 -0.1
Current tobacco smoking 0.8 1.2 2.9 1.2 1.7 -1.4 -0.1 0.5 0.7 -1.6 -0.4
Average weekly fortified wine intake 1.4 1.6 6.6 -0.9 0.6 1.3 2.6 -0.4 -1.2 1.2 -0.5
Maternal smoking around birth 2.1 3.0 8.7 1.2 1.9 -1.2 -2.9 1.7 2.0 -1.0 0.9
Fed-up feelings 0.4 0.8 2.3 -0.6 0.5 0.6 1.5 0.0 -1.3 0.9 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.1 0.8 0.4 -0.5 -0.6 1.0 0.3 -0.4 0.8
Relative age voice broke 0.2 0.2 1.3 -0.5 0.1 0.0 -0.3 -1.1 0.1 0.4 -0.3
Taking other prescription medications 0.4 0.5 2.1 -0.2 -0.5 -0.3 0.9 -0.7 -1.4 -0.2 -0.7
Age when periods started (menarche) 0.3 0.7 1.8 0.5 1.3 -0.8 -0.5 -0.2 0.3 -1.2 1.0
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 3.1 -1.4 -1.3 1.0 0.9 -1.3 -1.1 0.7 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.9 0.5 -1.4 -0.6 -0.9 -0.1 0.6 -1.0 -0.9
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.8 0.6 1.7 -0.7 1.0 0.2 -0.1 -1.0 0.4
Qualifications: CSEs or equivalent 0.4 0.6 3.7 -0.1 1.9 0.6 0.1 0.3 0.1 0.6 0.3
Serious illness, injury or assault to yourself 1.6 1.9 5.8 0.8 1.3 -1.4 -2.4 0.4 1.1 -1.5 1.2
High blood pressure 0.7 1.9 6.9 0.4 -2.6 0.3 -1.8 1.2 1.7 0.7 0.3
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.4 -0.9 0.0 0.1 0.5 -1.5 -0.5 0.1 -1.8
Multivitamins +/- minerals 1.0 1.3 3.8 -0.4 2.0 -0.5 1.6 -1.4 -0.8 -0.7 0.8
Stomach or abdominal pain in last month 0.9 1.1 3.8 -0.2 0.1 -0.0 1.8 -0.7 -2.0 0.2 -1.3
Supplements: Glucosamine 1.2 1.6 4.7 -0.5 -1.8 0.6 1.8 -0.6 -2.2 0.5 -0.8
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.4 0.0 -0.6 -0.3 0.2 -0.3 0.2 -0.2 0.2
Medication: Atenolol 0.4 0.5 0.9 -0.3 -0.9 -0.5 -0.9 -1.0 0.9 -0.4 -0.2
Medication: Levothyroxine sodium 0.2 0.3 0.6 -0.6 0.5 0.4 0.8 -0.6 -0.8 0.4 -0.1
Sitting height 0.2 1.4 4.9 -0.0 0.4 -0.7 -1.6 -0.8 2.2 -1.0 -1.1
Chronic bronchitis/emphysema (father) 0.3 0.3 1.1 0.6 1.1 -0.6 0.3 0.1 -0.6 -0.4 -0.5
High blood pressure (mother) 1.2 1.7 4.3 -1.8 -0.0 2.1 0.4 -1.2 -1.0 1.9 0.2
Body mass index (BMI) 0.1 0.5 0.8 0.8 -0.6 -0.9 -0.4 0.7 0.6 -0.8 -0.7
Impedance of leg (left) 1.0 4.9 10.4 -3.2 -1.4 2.7 1.0 -2.9 -1.5 2.5 -1.3
Leg predicted mass (left) 0.4 2.2 5.2 1.6 0.2 -1.5 -1.8 1.5 2.3 -1.5 -0.4
Trunk fat mass 0.1 0.6 1.3 -0.1 -0.9 -0.5 -1.0 -0.3 1.1 -0.6 -1.1
Waist circumference 0.2 0.8 1.2 0.7 -1.0 -1.1 -0.4 0.5 1.0 -0.9 -1.1
Number of incorrect matches in round 1.0 1.7 4.1 -1.0 -1.6 0.9 1.4 -1.1 -2.0 0.5 -1.3
Past tobacco smoking 0.9 1.7 4.6 -1.9 -0.3 2.1 -0.2 -1.2 -0.2 2.0 0.3
Alcohol usually taken with meals 0.3 0.5 1.2 -0.4 -0.4 0.1 1.1 -1.0 -0.6 -0.3 1.0
Nervous feelings 0.3 0.6 1.5 -0.7 -0.2 0.9 1.0 -0.3 -1.2 0.9 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.2 -1.1 -0.4 1.2 -0.5 -0.6 -0.4 1.5 -0.0
Hearing difficulty/problems with background noise 0.6 0.9 3.7 0.1 1.0 0.3 1.1 0.4 -1.9 0.8 0.5
Hair/balding pattern: Pattern 2 2.6 3.3 5.1 -2.0 0.0 2.3 2.0 -1.4 -2.0 2.0 -1.6
Had menopause 0.4 0.6 1.9 0.7 1.4 -0.8 -0.5 0.2 0.0 -1.0 0.2
Had other major operations 1.1 1.3 5.4 0.3 -2.3 -0.6 1.0 -0.1 0.2 -0.8 -1.7
Forced vital capacity (FVC) 0.5 1.9 3.4 -1.5 -1.6 1.5 -0.3 -1.1 -0.5 1.8 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.4 -0.2 -0.8 -0.3 -0.4 -1.2 0.3 -0.6 -1.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.6 -0.2 -1.3 1.0 0.1 0.7 -0.2 0.9 0.6
Qualifications: None of the above 0.7 1.6 3.6 1.5 0.8 -1.2 -1.4 1.9 0.6 -1.1 -1.0
Financial difficulties in last 2 years 0.1 0.2 0.7 0.6 -0.1 -0.4 -0.2 0.8 0.0 -0.4 -0.4
Mouth/teeth dental problems 0.4 0.7 1.4 -0.7 -1.2 0.9 -0.9 -0.4 0.6 1.1 0.1
Heart attack 1.4 1.8 4.7 -0.1 2.0 -0.8 -1.8 -0.6 1.2 -0.3 2.2
Allergy 0.4 0.9 2.2 0.1 -0.4 1.1 -0.5 1.4 0.3 1.1 1.5
Pain all over the body in last month 0.4 0.4 1.3 -0.3 -1.0 0.7 -0.2 0.4 -0.4 1.1 0.3
Diabetes (self-reported) 1.0 1.5 5.0 0.1 2.2 -0.6 1.4 -0.4 -2.0 -0.6 0.5
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 3.0 -0.3 -1.0 0.5 0.2 0.2 -1.6 0.7 -1.7
Medication: Ramipril 0.7 0.9 1.8 -0.9 0.1 1.2 1.4 -0.4 -0.9 1.2 0.3
Medication: Simvastatin 0.2 0.3 1.5 -0.5 -0.2 -0.1 0.1 -1.2 -0.4 0.4 -0.3
Fluid intelligence score 0.5 1.0 4.3 -0.3 -0.9 0.3 2.1 -1.2 -0.9 0.7 -0.5
Illnesses of siblings 0.4 0.5 1.2 0.5 0.3 -0.9 -0.3 -0.2 0.9 -1.1 0.8
Neuroticism score 0.3 0.6 2.2 0.5 0.3 -0.5 1.3 0.6 -0.2 -0.3 1.5
Weight 0.3 1.3 3.5 0.9 -0.4 -1.1 -1.5 0.6 1.9 -1.0 -0.8
Impedance of arm (right) 0.2 0.8 1.9 -1.1 -0.2 0.8 0.8 -1.3 -1.4 0.8 0.3
Arm fat percentage (right) 0.0 0.2 0.4 0.3 -0.6 -0.6 -0.1 -0.1 0.1 -0.6 -0.4
Trunk fat-free mass 0.4 2.4 6.5 1.5 0.3 -1.3 -2.1 1.5 2.5 -1.3 -0.4
Hip circumference 0.2 0.7 3.3 -0.2 -1.4 0.3 0.1 0.1 0.3 0.1 -1.8
Time employed in main current job 0.1 0.1 0.2 0.1 -0.3 -0.1 -0.3 0.5 0.3 0.3 0.2
Alcohol intake versus 10 years previously 0.4 0.6 1.9 0.2 1.4 0.1 1.0 0.0 -0.8 -0.5 -1.1
Father’s age at death 0.1 0.2 0.9 -0.3 0.4 0.1 1.0 -0.2 -0.1 -0.2 -0.5
Worrier / anxious feelings 0.9 1.6 3.5 -1.9 0.1 1.7 0.7 -1.4 -1.0 1.5 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 3.1 -1.0 -0.4 1.3 0.1 -0.2 0.3 1.8 -0.1
Falls in the last year 1.1 1.5 3.2 1.2 1.2 -1.4 -0.3 0.6 0.7 -1.8 1.6
Hair/balding pattern: Pattern 3 0.4 0.6 1.5 0.8 -1.2 -0.8 -0.9 0.6 0.4 -0.1 0.9
Number of live births 2.0 2.8 5.0 2.0 1.8 -2.2 -0.4 0.8 1.4 -2.2 1.6
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 3.2 -1.1 -1.8 1.4 -1.1 -0.4 0.3 1.6 -1.1
Pulse rate 0.7 1.2 6.3 -0.6 -1.2 0.5 0.3 -0.4 -0.6 0.6 -2.5
Happiness 0.9 1.1 2.8 -0.6 -1.3 0.6 1.7 -0.8 -1.2 0.7 -0.7
Noisy workplace 0.1 0.1 0.3 -0.1 0.5 0.4 0.0 0.3 -0.2 0.5 0.2
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.7 -0.5 -0.0 0.8 0.5 -0.1 -0.0 0.6 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.6 0.2 0.9 0.3 -0.3 0.6 0.4 0.4 1.3
Mouth/teeth dental problems: Dentures 0.8 1.3 2.4 1.1 1.5 -1.6 -1.3 0.8 0.4 -1.4 -0.5
Asthma 1.0 2.0 5.8 -1.4 -0.2 0.3 1.1 -2.4 -1.6 0.2 -2.0
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.3 -0.4 -0.6 1.1 1.2 0.0 -0.7 0.5 -1.0
Medication: Cholesterol lowering 0.2 0.4 1.5 -0.8 -0.1 -0.1 -0.6 -1.2 0.3 0.2 0.4
Depression (self-reported) 1.1 1.4 3.9 0.8 0.5 -1.0 -1.7 0.5 2.0 -1.1 0.9
Medication: Lansoprazole 0.1 0.1 0.4 0.0 -0.3 -0.5 0.7 -0.5 0.0 -0.1 0.3
Prospective memory result 0.2 0.2 0.7 0.6 0.7 -0.5 0.2 0.2 -0.3 -0.3 0.8
Lung cancer (father) 0.4 0.5 1.6 -0.7 1.3 0.2 -0.4 -0.8 -0.0 0.5 -0.7
Illnesses of mother 1.2 1.5 3.2 1.1 -1.4 -0.9 -1.5 1.2 1.8 -0.9 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 1.8 -1.1 -0.7 1.3 -1.3 -0.2 1.0 1.3 -0.6
Pulse wave Arterial Stiffness index 0.9 1.1 2.8 0.7 0.9 -1.0 -1.1 0.5 1.7 -0.8 1.1
Impedance of arm (left) 0.2 1.0 2.4 -1.3 -0.2 1.0 0.6 -1.5 -1.1 1.0 0.5
Arm fat mass (right) 0.1 0.5 0.9 0.5 -0.6 -0.7 -0.8 0.4 0.9 -0.7 -0.7
Trunk predicted mass 0.4 2.3 6.5 1.5 0.3 -1.3 -2.0 1.4 2.5 -1.3 -0.4
Standing height 0.1 1.4 6.1 0.1 0.3 -0.4 -2.2 -0.2 2.5 -0.3 -0.5
Length of working week for main job 0.6 0.6 1.9 -0.4 1.4 0.6 0.6 -0.2 -1.4 0.3 0.5
Exposure to tobacco smoke at home 1.2 1.3 3.9 1.2 0.5 -1.7 -0.7 0.4 1.2 -2.0 0.1
Breastfed as a baby 0.2 0.2 0.5 0.1 0.7 -0.4 0.1 -0.4 -0.3 -0.7 -0.4
Tense / ‘highly strung’ 0.0 0.1 0.2 0.2 0.1 -0.5 0.1 0.2 0.2 -0.2 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.5 -0.3 0.2 0.7 0.3 -0.1 -0.1 0.4 -0.1
Hair/balding pattern: Pattern 4 0.2 0.4 1.7 0.2 -0.3 -0.4 -0.9 -0.1 1.3 -0.6 -0.0
Birth weight of first child 0.2 0.4 2.1 -0.9 -0.2 0.3 -0.3 -1.5 -0.3 0.0 -0.4
Peak expiratory flow (PEF) 0.6 1.3 5.7 -1.0 -2.4 0.4 -0.9 -1.1 0.8 0.6 -0.8
Pulse wave reflection index 1.0 1.2 4.6 -0.7 -0.1 0.1 -1.8 -0.8 2.2 0.0 0.8
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.7 1.6 1.1 -1.0 -0.3 1.9 0.3 -0.8 0.8
Loud music exposure frequency 0.4 0.4 1.1 0.9 1.0 -0.7 0.5 0.6 0.2 -0.4 0.7
Qualifications: O levels/GCSEs or equivalent 3.6 5.8 10.6 -2.9 -1.4 3.2 2.0 -1.7 -2.2 3.1 -1.9
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.1 -0.1 -1.4 0.5 1.4 0.1 -0.8 0.3 -0.2
Blood clot in the leg (DVT) 3.7 4.8 7.5 2.3 2.3 -2.7 -1.7 1.3 1.9 -2.7 2.1
Medication: Paracetamol 0.4 0.7 1.8 0.7 0.0 -0.9 -0.8 0.8 1.4 -0.6 1.1
Headache pain in last month 0.1 0.2 1.1 0.1 -1.1 -0.3 0.5 0.0 0.4 -0.2 0.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.2 0.4 1.1 -0.1 -0.5 0.8 0.4 -0.6 -0.1
Glaucoma (self-reported) 0.4 0.5 0.8 -0.5 0.9 0.6 0.7 -0.6 -0.8 0.8 0.6
Gout (self-reported) 0.6 0.8 5.6 -0.3 -2.4 0.3 -0.2 0.3 -0.0 0.6 -0.6
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 4.0 -1.8 -0.1 1.6 1.5 -2.0 -1.8 1.5 -0.5
Medication: Amlodipine 0.6 0.8 5.6 -0.1 -2.4 0.3 0.2 0.6 0.3 0.3 -0.5
Medication: Ventolin 100micrograms inhaler 1.3 1.7 4.6 -0.8 -1.3 1.0 1.0 -0.7 -1.8 0.8 -2.1
Birth weight 0.7 1.4 5.1 -0.8 0.8 -0.1 -2.3 -1.3 1.5 -0.8 -0.7
Chronic bronchitis/emphysema (mother) 1.0 1.1 5.2 -1.0 0.8 0.8 0.4 -0.7 -0.6 0.7 -2.3
High blood pressure (siblings) 1.1 1.5 3.8 -1.1 -1.1 1.5 0.8 -0.3 -1.7 1.9 -0.3
Forced vital capacity (FVC), Best measure 0.3 1.1 1.9 -1.3 -0.6 1.3 -1.1 -0.8 0.7 1.4 -1.0
Body fat percentage 0.1 0.5 1.4 -0.5 -1.2 -0.2 -0.1 -0.8 0.2 -0.3 -1.2
Leg fat percentage (right) 0.3 1.1 3.0 -1.1 -1.6 0.3 0.4 -1.3 -0.0 0.2 -1.7
Arm fat-free mass (right) 0.4 1.8 6.7 0.8 -0.1 -0.9 -1.9 0.9 2.6 -0.8 -1.0
Exposure to tobacco smoke outside home 0.2 0.2 1.2 0.0 1.1 -0.4 0.5 -0.4 -0.2 -0.1 -0.2
Comparative body size at age 10 0.2 0.5 1.4 0.7 1.2 -0.9 -0.5 0.7 0.3 -0.4 0.3
Number of full brothers 0.4 0.5 1.3 0.8 -0.1 -0.3 -1.1 1.2 0.1 -0.5 -0.3
Worry too long after embarrassment 0.6 1.1 2.4 1.1 0.5 -1.1 1.5 0.5 0.0 -1.0 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 3.2 -1.2 -0.6 1.8 1.3 -0.6 -0.8 1.3 -0.7
Wheeze or whistling in the chest in last year 1.4 2.5 4.5 -1.6 0.0 1.0 1.6 -1.9 -2.1 1.3 -2.1
Number of children fathered 0.5 0.6 2.0 0.1 -1.4 -0.4 -1.3 0.1 0.9 0.1 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.6 -0.5 -0.2 0.8 -0.2 0.4 -0.1 0.8 0.4
Age at first live birth 0.4 0.7 1.8 0.5 0.7 0.0 -0.8 0.9 1.1 0.1 1.3
Pulse wave peak to peak time 0.7 0.8 2.1 -0.6 -0.7 0.8 1.0 -0.5 -1.4 0.6 -1.1
Health satisfaction 0.6 0.7 1.8 1.4 -0.2 -1.3 0.0 1.1 -0.2 -1.0 0.3
Shortness of breath walking on level ground 1.3 1.5 2.4 1.6 0.9 -1.3 -0.8 1.5 0.8 -1.3 1.4
Qualifications: College or University degree 0.2 0.8 2.6 0.2 -1.6 0.4 -0.1 0.6 0.7 0.2 1.6
Eye problems/disorders: None of the above 0.7 0.8 2.0 -1.0 -0.8 0.5 0.9 -1.4 -0.8 0.2 -0.8
Mouth/teeth dental problems: Loose teeth 2.1 2.6 9.6 -0.9 -0.2 0.5 3.1 -1.8 -2.0 0.6 -1.5
Emphysema/chronic bronchitis 1.0 1.1 2.3 0.7 1.1 -1.3 -0.8 0.1 0.8 -1.5 1.3
Medication for pain relief, constipation, heartburn 0.4 0.6 1.3 -0.9 0.6 0.7 0.7 -1.1 -1.0 0.6 -0.5
Neck or shoulder pain in last month 0.7 1.0 2.6 0.9 1.5 -1.6 0.2 0.2 -0.6 -1.4 -0.4
Medication: Blood pressure 0.3 0.5 1.2 0.5 -0.9 -0.3 -0.7 0.8 1.1 -0.1 0.8
Angina (self-reported) 0.9 1.2 5.6 -1.1 2.4 0.5 -0.9 -1.1 -0.4 0.5 0.4
Migraine (self-reported) 0.6 0.8 1.8 -0.8 -1.3 0.6 -0.1 -0.7 0.5 1.2 -1.1
Medication: Ibuprofen 1.2 1.4 2.9 -0.7 -1.0 1.5 1.7 -0.1 -1.1 0.9 -1.7
Medication: Allopurinol 0.4 0.5 2.0 0.0 -1.4 0.2 -0.9 0.6 0.6 0.9 0.0
Medication: Omeprazole 2.5 3.0 4.6 2.1 0.1 -2.0 -1.9 1.8 2.1 -1.7 1.1
Medication: Seretide 50 evohaler 1.1 1.2 3.8 -0.9 -0.8 0.2 0.9 -1.5 -1.9 0.5 -1.2
Mean time to correctly identify matches 0.3 0.5 3.2 -0.3 -0.1 0.3 -0.8 -0.2 -0.1 0.4 1.8
Heart disease (mother) 0.2 0.3 0.8 0.4 0.2 -0.9 -0.1 -0.6 -0.2 -0.8 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 1.1 0.4 -0.0 -0.7 -1.0 -0.1 0.6 -0.4 -0.1
Whole body fat mass 0.1 0.5 1.2 0.1 -0.8 -0.6 -0.8 -0.1 1.0 -0.6 -1.1
Leg fat mass (right) 0.2 0.6 2.4 -0.5 -1.2 0.1 -0.4 -0.6 0.7 0.0 -1.6
Arm predicted mass (right) 0.3 1.4 5.7 0.6 -0.3 -0.6 -1.6 0.6 2.4 -0.6 -1.2
Pulse rate, automated reading 0.4 1.3 5.8 0.9 -0.4 -1.0 0.8 1.3 -0.1 -0.9 -2.4
Alcohol intake frequency. 0.4 0.9 2.9 0.5 1.7 -0.8 -0.8 0.0 0.2 -0.5 1.6
Comparative height size at age 10 0.7 3.7 6.3 2.2 1.2 -2.1 -1.9 2.0 2.2 -2.5 0.6
Number of full sisters 0.2 0.2 0.6 0.1 0.8 0.2 -0.3 0.5 0.1 0.6 -0.4
Suffer from ‘nerves’ 0.4 0.6 2.1 0.3 -0.3 0.3 1.4 0.5 -1.4 -0.1 -0.6
Overall health rating 0.2 0.3 1.0 0.7 0.4 -1.0 0.5 0.2 -0.4 -0.7 0.1
Chest pain or discomfort 0.7 1.1 4.8 -1.5 0.8 0.6 0.1 -2.2 -0.5 0.7 -0.1
Had major operations 0.2 0.2 0.7 -0.3 0.8 0.0 0.2 -0.7 -0.3 0.3 -0.4
Age at last live birth 0.8 1.1 4.7 0.7 2.2 -0.6 -0.2 0.3 0.5 -0.5 1.6
Family relationship satisfaction 1.3 1.6 3.8 -1.3 -0.2 1.0 1.6 -1.9 -1.2 1.6 -0.1
Leg pain on walking 1.3 1.6 3.5 1.2 -1.6 -1.3 -1.9 1.1 1.1 -1.2 0.3
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 4.0 1.2 0.7 -1.8 0.3 -0.1 -0.1 -2.0 0.4
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.7 -0.8 0.7 0.3 -0.8 -0.7 -0.1 0.5 0.4
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.2 -0.5 -0.1 0.3 -0.1 0.4 -0.0 -0.3
Medication: Aspirin 0.3 0.4 1.0 0.7 0.4 -0.5 -0.6 1.0 0.4 -0.4 0.7
Supplements: Vitamin C 0.3 0.3 1.7 -0.3 -0.7 0.0 -1.3 -0.4 0.2 -0.2 -0.0
Knee pain experienced in last month 0.4 0.6 2.1 0.8 -0.4 -1.0 -0.7 0.3 0.2 -1.4 -0.7
Hypertension (Self-reported) 0.6 1.7 7.3 0.1 -2.7 0.5 -1.7 0.9 1.3 0.9 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 2.8 1.3 0.3 -0.9 -0.5 1.7 0.6 -1.1 1.0
Illnesses of father: Heart disease 0.7 1.0 3.2 1.1 -0.6 -0.5 -0.7 1.8 0.7 -0.0 1.4
Illnesses of siblings: Diabetes 1.0 1.2 4.9 -0.6 -0.1 1.3 0.8 0.4 -0.8 1.2 -2.2
Smoking status: Previous 0.7 1.0 2.9 1.3 -0.4 -1.7 0.4 0.3 -0.1 -1.6 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 4.5 0.4 -1.0 0.2 -2.1 1.5 1.2 0.2 -1.0
Whole body fat-free mass 0.4 2.2 6.0 1.5 0.2 -1.4 -1.9 1.4 2.5 -1.3 -0.6
Leg fat-free mass (right) 0.5 2.5 5.3 1.8 0.4 -1.7 -1.9 1.5 2.3 -1.6 -0.3
Arm fat percentage (left) 0.0 0.2 0.5 0.1 -0.7 -0.5 -0.0 -0.3 0.2 -0.5 -0.4
Average weekly red wine intake 0.2 0.4 1.5 0.4 -0.6 -0.3 -1.2 0.3 0.6 -0.4 0.5
Handedness (chirality/laterality): Left-handed 1.9 2.3 4.2 -1.8 0.0 2.1 1.4 -0.9 -1.6 2.0 -1.1
Mood swings 0.2 0.4 1.9 0.1 0.8 -0.0 0.5 0.8 -0.1 0.3 1.4
Loneliness, isolation 1.6 2.2 3.8 1.9 0.8 -1.8 -0.3 1.8 0.9 -1.4 1.9
Long-standing illness, disability or infirmity 0.5 0.7 1.4 0.7 1.1 -1.2 0.7 -0.4 -0.7 -1.1 0.5
Ever had bowel cancer screening 1.9 2.3 9.5 1.0 1.5 -1.3 -1.3 0.5 0.5 -1.1 3.1
Diabetes diagnosed by doctor 0.9 1.4 4.1 0.3 2.0 -0.8 1.5 -0.5 -1.7 -0.8 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.4 1.1 -0.4 -1.1 1.1 0.5 0.3 -1.2 0.3
Friendships satisfaction 1.6 1.9 3.3 -1.1 -1.6 1.8 1.8 -0.4 -1.2 1.7 -0.4
Qualifications: nursing, teaching 0.1 0.2 0.7 0.4 0.1 0.1 0.1 0.8 0.0 0.1 0.9
Commuting to job workplace: Walk 0.3 0.3 2.2 0.1 0.3 -0.2 1.5 -0.4 -0.4 -0.2 0.1
Eye problems/disorders: Cataract 1.8 2.1 4.3 1.9 1.3 -1.5 -0.9 2.1 0.6 -0.6 1.9
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.1 1.0 1.8 -0.7 0.1 1.3 0.7 -1.0 1.5
Medication for cholesterol 0.2 0.3 0.7 0.2 0.9 0.3 0.8 0.3 -0.6 0.4 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.7 0.1 -0.7 -0.0 -0.5 0.3 0.2 0.9 0.2
Back pain experienced in last month 0.5 0.8 2.5 -0.9 0.9 0.2 0.8 -1.6 -0.6 0.6 -0.9
Mineral and other dietary supplements 0.2 0.2 1.2 0.0 1.1 -0.0 -0.4 -0.1 0.4 0.5 -0.2
Breast cancer (self-reported) 0.5 0.6 2.7 -0.4 1.6 0.6 -0.8 0.3 0.2 0.7 0.1
Asthma (self-reported) 1.0 1.9 5.0 -1.3 -0.7 0.3 1.1 -2.2 -1.8 0.2 -1.9
Osteoporosis (self-reported) 0.9 1.2 4.7 0.5 2.2 -0.5 -1.3 0.6 0.4 -0.7 1.2
Osteoarthritis (self-reported) 2.1 2.7 9.9 -1.1 -1.8 1.0 1.9 -0.9 -1.1 0.9 -3.1
Medication: Aspirin 0.7 0.9 2.0 0.9 0.1 -0.5 -1.4 1.4 1.0 -0.5 1.0
Medication: Gliclazide 0.9 1.0 1.7 0.9 0.2 -1.2 -1.1 0.2 1.0 -1.3 1.3
Illnesses of father: None of the above (group 1) 0.8 1.0 2.5 0.5 1.6 -0.9 -0.9 -0.6 1.1 -1.1 0.8
Smoking status: Current 0.8 1.3 3.4 1.1 1.5 -1.5 0.1 0.3 0.8 -1.9 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 3.3 -1.2 -0.9 1.2 0.9 -0.5 -0.4 1.8 -1.3
Whole body water mass 0.4 2.4 6.3 1.6 0.3 -1.4 -2.0 1.5 2.5 -1.4 -0.5
Leg predicted mass (right) 0.5 2.5 5.3 1.8 0.3 -1.7 -1.9 1.5 2.3 -1.6 -0.3
Arm fat mass (left) 0.1 0.4 0.9 0.4 -0.6 -0.6 -0.6 0.2 0.9 -0.6 -0.7
Number of self-reported non-cancer illnesses 0.3 0.5 1.7 -0.1 -0.8 -0.5 0.4 -0.6 -1.3 0.2 -0.8
Average weekly champagne plus white wine intake 0.3 0.4 1.2 0.4 -1.1 -0.4 -0.3 0.5 0.4 -0.0 0.9
Miserableness 0.4 0.8 3.5 -0.2 0.1 0.5 0.9 0.5 -0.5 0.9 1.9
Guilty feelings 0.2 0.2 1.2 -0.0 -1.1 -0.1 -0.0 0.0 0.6 -0.2 -0.5
Wears glasses or contact lenses 0.2 0.2 0.7 -0.2 -0.3 -0.4 0.8 -0.8 -0.7 -0.0 0.1
Ever taken oral contraceptive pill 0.6 0.7 2.9 0.7 0.4 0.5 0.4 1.7 -0.3 0.7 1.0
Hearing aid user 4.3 4.8 11.0 3.3 2.2 -2.8 0.6 2.8 0.1 -2.1 1.6
Mother’s age at death 0.4 0.5 2.7 0.2 -1.6 -0.1 -0.5 0.6 0.2 -0.2 -0.6
Financial situation satisfaction 0.3 0.4 0.8 -0.4 -0.9 0.1 0.7 -0.7 -0.5 0.2 -0.8
Tinnitus: Yes, now most or all of the time 1.3 1.5 4.5 0.5 -0.9 -1.1 -2.0 -0.4 2.1 -1.2 0.1
Commuting to job workplace: Public transport 1.2 1.4 3.7 -1.0 -0.4 1.6 1.2 -0.4 -1.3 1.9 -0.9
Eye problems/disorders: Glaucoma 0.5 0.6 1.8 -0.2 0.6 0.5 1.2 -0.1 -1.3 0.6 0.6
Medication: Blood pressure 0.2 0.3 1.8 -0.1 -1.3 -0.1 0.5 -0.3 -0.4 0.2 -0.3
Pain type(s) experienced in last month: Hip pain 0.4 0.6 1.7 -0.7 -1.1 -0.1 0.6 -1.3 -0.5 0.1 -0.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.2 0.2 1.0 -0.6 0.4 -0.2 -0.1 -1.0 1.1
High cholesterol (Self-reported) 0.3 0.5 1.1 -0.8 -0.3 0.4 -0.7 -0.8 0.1 0.7 -1.0
Medication: Bendroflumethiazide 0.2 0.2 0.8 0.7 -0.4 -0.5 0.9 0.4 -0.1 -0.1 0.3
Medication: Paracetamol 0.2 0.3 1.2 0.3 -0.3 -0.1 -0.0 1.1 0.6 0.1 0.6
Medication: Lisinopril 1.8 2.4 5.9 2.2 0.6 -1.7 -0.6 2.4 0.6 -1.5 1.4
Medication: Atorvastatin 1.0 1.2 3.2 0.9 1.6 -1.6 -0.6 -0.2 0.7 -1.8 0.2
Illnesses of father: High blood pressure 0.9 1.1 2.2 -1.0 -0.1 1.3 1.5 -0.4 -1.3 1.1 0.7
Alcohol drinker status: Never 0.5 0.6 1.3 -0.9 0.9 1.0 0.1 -0.3 -1.0 1.1 -0.0
Ever smoked 1.1 2.0 3.9 2.0 1.6 -1.8 0.4 1.6 -0.4 -1.8 -0.6
Basal metabolic rate 0.4 2.2 6.1 1.4 0.0 -1.3 -2.0 1.4 2.5 -1.3 -0.6
Leg fat percentage (left) 0.3 0.9 2.7 -0.8 -1.4 -0.1 0.3 -1.3 0.2 -0.1 -1.6
Arm fat-free mass (left) 0.3 1.6 4.7 0.9 -0.1 -0.9 -1.6 0.9 2.2 -1.0 -1.3
Number of operations (self-reported) 0.6 0.9 3.0 -0.5 -1.4 -0.4 0.5 -1.3 -0.0 -0.4 -1.7
Average weekly beer plus cider intake 0.4 0.6 1.4 -1.1 0.3 0.7 -0.7 -1.2 -0.4 1.1 -0.1
Irritability 0.3 0.5 1.2 0.2 0.2 -0.1 -1.0 0.4 1.1 0.2 1.1
Risk taking 1.3 1.9 3.1 1.8 -0.3 -1.5 -1.3 1.7 1.4 -1.3 1.1
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.8 -0.8 1.1 -0.1 0.3 -1.3 -0.1 -0.2 1.0
Fractured/broken bones in last 5 years 1.3 1.7 3.9 1.0 0.6 -1.8 -1.3 -0.3 2.0 -1.8 0.4
Age started oral contraceptive pill 2.2 2.8 4.8 2.2 1.9 -1.6 0.9 1.9 1.2 -2.0 1.0
Diastolic blood pressure, automated reading 0.3 0.9 4.5 -0.8 -2.1 0.7 -0.4 -0.9 0.1 0.9 -0.3
Ever depressed for a whole week 0.6 0.7 2.5 1.1 -0.1 -0.4 0.6 1.6 0.0 -0.5 0.9
Unable to work because of sickness or disability 0.6 0.8 1.2 1.0 -0.6 -1.0 -1.1 0.8 1.0 -1.1 -0.1
Commuting to job workplace: Cycle 3.8 4.6 8.4 2.4 -0.0 -2.3 -2.2 2.1 2.9 -2.5 1.4
Myopia 0.2 0.4 1.4 0.4 -0.1 0.0 0.5 0.7 -0.8 0.2 1.2
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.6 0.2 1.9 -0.5 1.4 -0.3 -1.2 -1.0 -0.3
Cholesterol lowering medication 0.3 0.5 1.5 0.0 1.2 -0.6 -0.0 -0.9 -0.1 -0.3 -1.1
Medication: Omeprazole (e.g. Zanprol) 3.2 3.8 6.6 2.4 0.6 -2.6 -2.1 1.6 2.0 -2.4 1.1
Pain experienced in last month 0.3 0.5 1.3 -0.8 0.6 1.0 0.2 -0.3 -0.1 1.2 0.7
Supplements: Calcium 0.4 0.5 1.6 -0.2 -1.3 0.2 0.1 -0.6 0.3 -0.6 -1.1
Basal cell carcinoma (self-reported) 0.2 0.2 0.8 0.1 -0.1 0.1 0.4 0.7 -0.9 0.3 -0.1
Heart attack/myocardial infarction (self-reported) 1.4 1.9 5.3 -0.2 1.9 -0.8 -1.8 -0.8 1.2 -0.3 2.3
Deep venous thrombosis (DVT) (self-reported) 2.8 3.6 6.3 2.0 2.0 -2.5 -1.4 0.8 1.6 -2.4 1.8
Heart disease (siblings) 0.4 0.5 1.4 0.5 1.2 -0.9 0.4 -0.4 -1.0 -0.5 -0.4
Alcohol drinker status: Previous 0.5 0.5 0.8 0.8 0.4 -0.8 -0.7 0.5 0.9 -0.7 0.7
Pack years of smoking 0.8 1.1 3.7 0.7 1.9 -1.2 -1.1 0.3 0.5 -0.9 0.9
Impedance of whole body 0.4 2.3 5.8 -2.3 -0.8 1.7 0.7 -2.4 -1.1 1.4 -0.4
Leg fat mass (left) 0.1 0.6 2.0 -0.3 -1.1 -0.2 -0.5 -0.5 0.8 -0.2 -1.4
Arm predicted mass (left) 0.3 1.7 4.6 1.2 -0.2 -1.1 -1.5 1.1 2.1 -1.2 -1.3