Hub : Genes

COLCA2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2750	0.0550	2.8e-08	0.158	NA	0.133	NA	0.156	6.2e-13	NA	5.7e-11	NA	9.8e-13
2	GTEx	Adipose Visceral Omentum	0.1700	0.0710	8.3e-03	0.088	NA	0.057	NA	0.078	2.6e-05	NA	6.3e-04	NA	7.4e-05
3	GTEx	Artery Aorta	0.0930	0.0390	5.0e-03	0.100	NA	0.037	NA	0.068	3.7e-06	NA	3.9e-03	NA	1.3e-04
4	GTEx	Artery Tibial	0.2281	0.0563	2.5e-07	0.024	NA	0.079	NA	0.058	4.9e-03	NA	9.4e-07	NA	2.4e-05
5	GTEx	Cells EBV-transformed lymphocytes	0.2310	0.0750	3.4e-03	0.107	NA	0.257	NA	0.220	2.3e-04	NA	6.2e-09	NA	9.5e-08
6	GTEx	Cells Transformed fibroblasts	0.1420	0.0580	4.9e-03	0.080	NA	0.071	NA	0.091	1.4e-06	NA	5.2e-06	NA	2.6e-07
7	GTEx	Colon Transverse	0.5070	0.0600	0.0e+00	0.428	NA	0.466	NA	0.454	4.4e-22	NA	1.4e-24	NA	9.1e-24
8	GTEx	Esophagus Mucosa	0.1470	0.0440	2.6e-04	0.053	NA	0.104	NA	0.125	1.9e-04	NA	2.0e-07	NA	1.0e-08
9	GTEx	Lung	0.1003	0.0383	1.5e-03	0.014	NA	0.000	NA	-0.001	2.7e-02	NA	3.0e-01	NA	4.1e-01
10	GTEx	Muscle Skeletal	0.0633	0.0259	4.1e-03	0.018	NA	0.005	NA	0.011	6.7e-03	NA	8.6e-02	NA	2.9e-02
11	GTEx	Small Intestine Terminal Ileum	0.3160	0.1300	6.0e-03	0.197	NA	-0.014	NA	0.093	3.5e-05	NA	9.9e-01	NA	4.2e-03
12	METSIM	Adipose	0.0561	0.0212	1.3e-03	0.051	0.018	0.035	0.026	0.042	4.2e-08	0.00096	4.7e-06	6.6e-05	5.6e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.5	0.8	3.6	0.5	0.7	-0.4	0.3	-0.2	0.5	-1.5	1.1	-0.2	-1.0	-1.9	0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	3.3	1.6	1.5	0.2	0.4	-0.9	1.5	-1.2	-0.2	0.1	-0.1	-1.5	1.8
Depressed Affect (Nagel 2018)	0.5	0.9	3.0	-0.2	-0.2	1.3	1.2	-0.1	-0.2	1.0	-0.9	1.2	1.7	1.3	-0.2
Depression (Nagel 2018)	0.2	0.3	0.9	-0.7	-0.7	-0.5	-0.2	0.9	-0.2	-0.3	0.6	0.0	-0.3	-0.6	-0.8
Intelligence (Savage-Jansen 2018)	0.3	0.8	4.1	-0.5	-0.5	-0.2	0.7	0.8	-0.5	1.5	0.5	0.4	0.5	2.0	-0.6
Neuroticism (Nagel 2018)	0.3	0.8	1.8	-0.5	-0.6	1.2	0.8	0.1	-0.8	1.3	0.3	0.7	1.2	1.3	-0.6
Schizophrenia (2018)	0.5	1.1	2.8	1.6	1.4	0.7	0.2	-1.0	1.5	-0.4	-1.1	0.3	0.7	-0.3	1.7
Schizophrenia vs Biploar Disorder	0.5	0.6	2.4	0.6	0.5	-0.5	-0.4	0.2	0.4	-1.6	-1.0	-0.9	-0.7	-0.8	0.7
Worry (Nagel 2018)	0.7	1.5	3.4	-1.0	-1.6	1.7	0.3	0.5	-1.5	1.8	1.2	1.1	0.7	1.3	-1.1
Alzheimer’s Disease (in mother)	1.3	1.5	4.2	2.0	1.5	1.2	-0.7	-1.0	2.0	-0.2	-0.7	-0.4	-0.1	0.3	2.0
Alzheimer’s Disease (in father)	0.6	0.7	1.5	-1.2	-0.7	-1.2	-0.5	0.8	-0.9	1.0	0.0	0.8	-0.3	0.3	-1.1
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	-0.3	-0.3	-0.7	-1.0	0.8	0.1	0.5	0.3	-0.1	-1.0	0.3	-0.2
Crohns Disease (2017)	0.8	1.7	9.2	-0.0	0.7	0.5	3.0	-0.9	0.6	-0.9	-1.9	0.4	2.1	-0.7	-0.1
Irritable Bowel Disease (IBD)	0.9	2.1	7.7	1.0	1.3	1.1	2.3	-1.3	1.2	-0.8	-2.8	0.1	1.8	-0.1	0.8
Ulcerative Colitis (UC)	1.1	2.0	8.7	1.6	1.5	1.3	0.7	-1.4	1.4	-0.9	-3.0	-0.4	1.1	0.1	1.4
Major Depression (MDD)	0.6	0.7	2.4	0.8	1.1	0.1	1.6	-0.6	0.9	-1.1	0.1	-0.2	0.4	-1.0	0.5
Reaction Time	0.8	1.5	3.4	-1.7	-1.7	-0.9	0.4	1.6	-1.8	0.3	0.7	-1.6	-0.5	0.2	-1.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	5.5	-0.1	0.1	-0.3	1.0	0.2	0.3	1.7	-0.5	0.7	0.8	2.3	-0.2
Breast Cancer	1.0	2.4	5.7	-0.8	-1.6	0.8	1.0	1.3	-1.1	1.9	2.4	2.1	-0.9	2.3	-0.8
Ovarian Cancer	0.6	0.7	2.1	0.3	-0.1	-0.7	-1.1	0.4	0.1	-1.5	1.0	-1.4	-1.1	-0.5	0.4
Prostate Cancer	0.1	0.2	0.9	-0.0	0.2	0.1	-0.2	-0.9	0.1	0.4	0.5	-0.6	0.2	-0.3	0.1
Age at First Birth	0.6	0.8	3.3	-0.4	-0.4	-1.5	-1.8	0.9	-0.6	-0.0	1.1	-0.4	-1.2	-0.3	-0.2
Bipolar Disorder (2011)	0.7	0.7	5.5	-0.1	0.1	-0.5	2.4	0.1	0.0	-0.3	1.2	0.1	-0.5	-0.8	-0.1
Body Mass Index (BMI) (2010)	1.4	1.9	4.4	-1.8	-2.1	-0.3	-0.4	1.6	-1.8	1.4	1.2	0.2	-1.1	0.9	-1.8
Coronary Artery Disease (CAD)	2.9	3.5	6.9	1.9	2.0	1.9	1.6	-1.9	2.5	-0.3	-2.6	0.4	2.4	1.0	2.0
Crohns Disease (2012)	0.9	1.5	7.3	-0.1	0.6	-0.4	1.6	-0.6	0.3	-2.4	-1.0	0.1	0.8	-2.7	-0.2
Mean Putamen Volume	0.2	0.3	0.7	0.7	0.5	-0.3	0.3	-0.6	0.6	0.1	0.4	-0.6	-0.8	-0.2	0.7
Fasting Glucose	1.5	1.8	5.0	0.5	0.3	1.4	1.1	-0.4	0.1	2.1	-0.7	2.2	1.8	2.1	0.5
HbA1C	1.6	1.7	8.0	0.6	-0.2	1.8	0.3	-1.1	0.0	2.3	0.2	1.1	1.1	2.8	0.2
HDL Cholesterol	0.8	1.3	5.1	-1.1	-0.7	1.0	2.3	0.2	-1.0	0.6	0.5	1.3	1.8	-0.2	-0.9
LDL Cholesterol	2.5	4.0	8.6	2.5	2.4	-0.5	-2.1	-1.8	2.9	-1.3	-1.8	-2.9	-0.8	-0.7	2.3
Lupus	1.6	2.4	6.4	2.4	1.7	1.0	-0.4	-2.3	1.7	-0.5	-1.5	-0.5	0.7	0.6	2.5
Neuroticism (2016)	0.3	0.4	1.9	-0.3	-0.1	0.4	1.4	-0.1	-0.1	0.6	-0.2	1.3	0.4	0.4	-0.3
Primary Biliary Cirrhosis	2.4	3.4	10.9	-1.1	-1.0	-3.3	-0.4	2.5	-0.8	0.0	2.8	-1.0	-3.3	0.3	-1.0
Rheumatoid Arthritis	0.4	0.5	2.2	0.6	1.1	-1.5	-0.3	-0.0	1.2	-0.4	0.3	-0.3	0.3	0.4	0.7
Schizophrenia (2014)	0.4	0.9	2.3	1.2	1.2	-0.1	-0.2	-0.3	1.1	-1.4	-0.6	0.5	0.1	-1.5	1.3
Triglycerides	0.6	1.0	2.6	1.6	1.6	-1.0	0.4	-0.4	1.6	-0.4	-0.3	0.5	-0.7	0.4	1.5
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.7	-1.1	-1.6	0.9	0.8	1.2	-1.5	1.5	1.5	1.6	-0.7	1.0	-1.2
Ulcerative Colitis	0.8	1.2	4.9	1.2	1.1	1.1	0.2	-1.0	1.3	-0.8	-2.2	-0.6	0.6	-0.3	1.0
Blood Eosinophil Count	1.8	14.1	46.9	3.2	2.9	5.4	-0.1	-5.4	3.3	-0.5	-4.9	-1.5	6.8	0.2	2.9
Blood Platelet Count	0.3	3.4	8.1	-1.1	-1.5	2.7	2.8	-0.5	-1.7	2.7	-0.4	2.1	1.6	1.9	-1.1
Blood Red Count	1.3	12.2	30.6	2.4	3.3	-5.5	-3.2	-0.7	2.9	-4.0	2.3	-3.5	-5.0	-3.7	2.6
Blood White Count	0.1	1.0	3.2	0.4	0.1	1.5	0.6	-1.1	0.4	1.8	-0.4	1.1	1.0	1.6	0.2
Heel T-Score	0.3	2.7	5.5	2.2	2.4	0.9	-0.4	-1.7	2.1	-0.9	-2.0	0.9	2.0	-0.1	2.1
BMI	0.1	0.5	2.8	-0.5	-0.2	-1.1	-1.7	-0.1	-0.3	-0.6	-0.8	-0.7	-0.3	-0.3	-0.7
Height	0.2	4.2	12.2	1.8	2.3	-2.5	-0.6	-0.1	2.8	-3.5	-0.3	-1.6	-1.7	-2.4	2.0
Waist Hip Ratio (WHR)	1.4	6.1	13.8	3.6	3.7	-0.8	-2.5	-1.6	3.7	-1.2	-0.6	-2.2	-1.5	-1.4	3.6
Systolic Blood Pressure	0.8	3.8	12.3	-1.5	-2.0	-1.4	-3.5	0.8	-1.6	-0.9	1.8	-3.4	-2.0	-1.0	-1.4
Smoking Status	2.8	6.6	13.5	2.9	3.0	2.4	0.1	-3.7	2.8	0.3	-3.0	2.4	3.3	1.2	2.7
Allergy or Eczema	1.1	3.0	9.0	0.8	0.4	2.8	1.4	-1.1	0.2	1.5	-2.5	2.2	3.0	1.2	0.6
Cardiovascular Disease	1.4	4.7	11.9	-2.0	-2.1	-2.7	-3.5	1.9	-1.7	-1.0	1.7	-3.1	-2.0	-0.7	-2.0
Hypothyroidism (self reported)	1.6	3.7	7.4	-2.6	-2.4	-1.2	-0.3	1.4	-2.2	2.2	2.7	0.9	-0.3	1.7	-2.7
Respiratory disease	2.9	6.4	17.4	1.8	1.2	4.2	2.8	-3.2	1.5	1.7	-2.4	2.1	4.1	1.5	1.5
Type 2 Diabetes (T2D) (2018)	0.9	1.8	5.1	-0.3	-0.3	1.6	1.5	-0.9	-0.3	2.0	-1.1	1.4	1.6	2.3	-0.4
Lung FEV1/FVC ratio	0.1	0.4	2.2	0.3	-0.0	0.2	-1.5	-0.4	0.6	-0.8	0.1	1.1	-0.3	-0.5	0.2
Lung FVC	0.2	1.1	3.2	0.9	0.8	-1.2	-1.8	-0.2	1.0	-0.4	0.5	-1.6	-1.1	-0.6	1.1
Neuroticism	0.2	0.4	1.6	0.3	0.3	0.6	0.4	-0.4	0.1	0.7	0.1	1.1	0.4	1.2	0.4
Chronotype (morning person)	0.1	0.2	0.7	-0.6	-0.4	0.1	0.7	0.5	-0.1	0.2	-0.1	-0.9	-0.2	-0.4	-0.6
Hair Pigment	0.0	0.6	3.6	0.1	-0.6	1.1	0.4	0.0	-0.2	0.9	1.0	0.5	0.6	1.9	0.0
Tanning	0.1	1.5	3.0	0.1	0.4	-1.4	-1.7	0.6	0.3	-1.5	1.3	-1.6	-1.6	-1.7	0.3
Hand grip strength (left)	0.8	2.2	6.8	0.4	1.0	-2.2	0.4	1.0	0.8	-2.6	0.5	0.1	-2.1	-2.5	0.5
Number of treatments/medications taken	0.3	0.6	4.0	0.8	0.2	0.4	-2.0	-0.8	0.5	-0.2	-0.4	-0.6	0.7	0.1	0.7
Average weekly spirits intake	0.6	0.7	1.9	1.3	0.9	0.6	0.0	-1.0	1.2	-0.7	-0.7	0.2	0.0	-0.4	1.4
Sensitivity / hurt feelings	0.6	1.1	4.9	0.5	0.8	0.9	2.2	-0.7	0.5	0.4	-1.3	1.3	0.6	1.1	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	2.0	0.3	-0.3	1.4	-0.5	-0.3	0.1	0.2	-0.7	-0.2	0.9	-0.4	0.2
Hearing difficulty/problems: Yes	0.9	1.4	4.2	0.6	0.6	1.6	1.2	-0.9	0.8	1.4	-0.5	2.1	1.5	1.3	0.5
Relative age of first facial hair	0.1	0.1	0.6	0.1	-0.1	0.5	0.1	-0.4	-0.2	0.8	0.2	0.4	-0.0	-0.6	0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	3.6	0.3	-0.1	0.5	-1.0	-0.5	0.1	-0.5	0.4	-1.9	0.0	-0.6	0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.4	0.2	0.0	1.2	-0.6	-0.9	0.4	-0.1	-1.1	0.5	0.8	-0.3	0.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	-0.1	-0.5	-0.2	-0.8	0.4	-0.3	0.3	0.6	0.2	-0.7	0.1	-0.0
Systolic blood pressure, automated reading	0.2	0.7	2.1	-1.0	-1.2	-0.5	-1.5	0.1	-0.8	0.1	0.7	-1.0	-0.5	0.0	-1.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.3	0.9	1.1	-0.5	0.0	-0.4	0.8	-1.1	-0.7	0.6	-0.9	-0.4	1.1
Angina	0.2	0.3	1.1	-0.3	-0.5	1.1	-0.3	0.2	-0.3	-0.2	-0.5	0.5	0.6	-0.6	-0.3
Medication for hormone replacement therapy	0.6	0.7	3.6	0.5	0.1	0.5	-1.9	-0.4	0.5	-1.2	-0.6	-0.2	-0.1	-1.4	0.6
Vitamin and mineral supplements	0.9	1.3	4.3	-0.4	-0.3	-1.6	-1.3	0.7	-0.2	-1.3	0.6	-2.1	-1.6	-1.0	-0.3
Supplements: Zinc	1.5	1.7	3.6	-1.3	-1.0	-1.7	1.0	1.9	-1.4	-0.4	1.7	0.9	-1.4	-0.3	-1.2
Medication: Co-codamol	1.2	1.4	4.0	-0.7	-0.7	1.4	0.7	-0.3	-0.5	2.0	-0.2	1.8	1.1	1.9	-0.8
Medication: Metformin	0.7	1.0	1.7	1.3	1.3	0.5	0.6	-1.2	1.3	-1.1	-1.3	0.3	0.2	-0.1	1.3
Diabetes (father)	0.4	0.5	3.1	-0.5	-0.6	0.5	-0.1	0.7	-0.9	0.8	0.3	1.8	0.2	0.5	-0.5
Diabetes (mother)	0.8	1.1	3.4	0.0	0.2	1.6	0.3	-0.7	0.1	1.7	-0.1	0.9	1.8	1.7	0.0
Severe depression (siblings)	1.5	1.7	5.3	-0.9	-1.0	-1.6	-2.3	0.9	-1.1	-0.5	1.0	-0.9	-1.7	-1.7	-0.9
Pack years adult smoking proportion	0.4	0.6	1.7	0.7	0.6	0.8	-0.0	-1.3	0.8	-0.8	-0.6	-0.5	1.1	-0.8	0.6
Impedance of leg (right)	1.0	5.0	10.6	-3.0	-2.9	-1.4	-0.9	3.3	-2.9	1.2	2.9	-0.1	-1.8	-0.2	-2.9
Leg fat-free mass (left)	0.3	1.6	5.1	1.3	1.5	-1.4	-0.2	-0.9	1.5	-2.3	-1.5	-0.7	-0.6	-0.9	1.3
Trunk fat percentage	0.1	0.5	2.7	0.1	0.4	-0.6	-1.2	-0.7	0.5	-0.5	-1.6	-0.4	0.3	-0.1	0.1
Hand grip strength (right)	0.4	1.2	3.5	0.2	0.4	-1.4	0.7	1.2	0.4	-1.7	0.8	0.1	-1.9	-1.8	0.3
Townsend deprivation index at recruitment	0.3	0.5	1.5	0.4	0.4	0.9	-0.4	-0.8	0.3	-0.7	-0.6	0.9	1.2	-0.7	0.2
Current tobacco smoking	1.2	2.0	6.6	1.1	1.5	1.2	0.1	-2.1	1.3	0.1	-2.1	0.6	2.6	0.5	0.9
Average weekly fortified wine intake	2.3	2.6	6.9	-1.2	-1.1	-0.9	2.6	2.0	-1.1	2.1	1.7	1.2	-0.7	2.3	-1.2
Maternal smoking around birth	1.4	2.0	8.9	1.4	1.3	0.3	-0.4	-0.9	0.9	-2.5	-0.0	-0.4	-0.9	-3.0	1.5
Fed-up feelings	0.7	1.3	3.7	-0.7	-0.8	1.4	1.2	-0.2	-0.7	1.7	-0.4	1.3	1.4	1.9	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	0.6	0.4	0.5	0.0	-0.1	0.9	-0.8	-0.8	-0.2	-0.1	-0.5	0.6
Relative age voice broke	0.1	0.1	0.4	-0.1	0.0	-0.2	-0.5	-0.5	-0.1	0.3	-0.0	0.6	-0.3	-0.4	-0.1
Taking other prescription medications	0.9	1.4	6.4	0.3	-0.3	2.3	-0.1	-1.2	-0.0	1.0	-0.8	0.7	2.5	1.2	0.1
Age when periods started (menarche)	0.3	0.7	1.4	0.8	0.9	1.0	0.9	-1.2	0.7	-0.3	-1.1	0.5	0.8	-0.5	0.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.0	-1.1	-1.1	-1.4	-0.1	0.7	-0.9	0.6	1.0	0.2	-1.3	0.3	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.6	0.4	0.7	0.1	-0.3	-0.8	0.6	-1.1	-1.6	0.0	1.1	-0.6	0.2
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	4.7	0.7	0.8	0.3	2.2	-0.9	0.7	0.9	-0.7	0.2	-0.0	1.4	0.6
Qualifications: CSEs or equivalent	0.2	0.2	1.2	-0.4	-0.4	0.5	-0.2	-0.2	-0.2	0.0	0.4	1.1	-0.2	0.1	-0.6
Serious illness, injury or assault to yourself	2.0	2.4	4.1	1.5	1.4	1.6	-0.0	-1.6	1.6	-2.0	-1.3	-1.7	1.3	-2.0	1.6
High blood pressure	1.8	4.9	22.8	-0.1	-0.4	-2.6	-4.8	0.7	0.0	-2.3	1.2	-3.4	-2.9	-1.3	0.0
Hayfever, allergic rhinitis or eczema	0.4	1.0	3.7	-0.1	-0.2	1.4	0.6	0.0	-0.2	0.5	-1.7	1.6	1.9	0.1	-0.3
Multivitamins +/- minerals	2.9	3.7	15.8	0.3	0.7	2.2	2.6	-1.2	0.6	1.9	-1.3	4.0	2.5	1.8	0.2
Stomach or abdominal pain in last month	1.5	1.8	3.9	-0.0	-0.2	1.7	1.8	-0.5	0.2	1.9	-1.3	1.7	2.0	1.9	-0.1
Supplements: Glucosamine	0.6	0.7	3.0	-0.3	-1.1	1.0	-0.2	0.2	-0.5	1.7	0.4	-0.1	-0.4	1.7	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.0	0.3	-0.1	0.3	-0.5	0.6	0.1	-0.3	0.2	-0.2	-0.2	0.1
Medication: Atenolol	0.9	1.1	4.9	0.6	0.5	-0.9	-1.3	-0.1	0.8	-1.3	0.2	-2.2	-1.2	-1.0	0.7
Medication: Levothyroxine sodium	0.2	0.4	1.1	-0.7	-0.6	0.4	0.1	-0.7	-0.5	0.9	0.4	0.3	1.1	0.7	-0.7
Sitting height	0.2	1.2	4.2	0.5	1.1	-2.0	0.4	0.0	0.8	-1.9	0.2	-1.2	-1.2	-0.5	0.6
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	0.6	0.4	0.9	-0.8	-0.9	0.7	0.3	-0.2	0.3	0.9	0.5	0.5
High blood pressure (mother)	1.8	2.6	5.1	-2.0	-1.9	-1.2	-0.5	2.2	-2.0	0.1	1.6	-1.0	-2.3	0.8	-1.9
Body mass index (BMI)	0.2	0.8	4.6	0.7	0.9	-0.3	-0.6	-1.4	0.9	-0.5	-2.1	-0.2	0.4	0.3	0.7
Impedance of leg (left)	0.9	4.2	8.8	-2.8	-2.6	-1.3	-0.7	3.0	-2.6	1.3	2.6	-0.1	-1.4	-0.2	-2.7
Leg predicted mass (left)	0.3	1.6	5.0	1.3	1.5	-1.3	-0.2	-0.9	1.5	-2.2	-1.5	-0.7	-0.5	-0.9	1.3
Trunk fat mass	0.2	0.7	2.6	0.3	0.6	-1.1	-1.1	-0.6	0.7	-1.1	-1.6	-0.6	-0.2	-0.4	0.3
Waist circumference	0.3	1.0	2.5	0.9	1.1	-0.8	-1.6	-1.1	1.2	-0.2	-1.5	-0.7	-0.3	0.2	0.9
Number of incorrect matches in round	0.5	0.9	2.3	-0.9	-1.1	0.6	1.1	0.4	-0.7	1.2	-0.3	1.2	0.7	1.5	-0.9
Past tobacco smoking	1.4	2.6	5.3	-2.3	-2.0	-1.5	0.5	1.9	-2.3	0.1	1.4	-0.8	-1.3	-1.1	-2.2
Alcohol usually taken with meals	0.1	0.2	0.8	-0.1	0.1	-0.2	0.9	0.3	-0.2	0.8	0.2	0.1	-0.3	0.7	0.1
Nervous feelings	0.4	0.7	1.3	-0.8	-1.1	0.9	0.4	0.1	-1.0	1.1	0.4	0.9	0.8	1.0	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.7	-1.2	-1.3	-0.5	-0.0	0.5	-1.1	-0.2	0.8	-1.1	-0.8	-0.9	-1.2
Hearing difficulty/problems with background noise	0.4	0.7	2.9	0.0	-0.6	1.7	-0.9	-0.3	-0.1	1.3	0.1	0.0	0.9	1.2	-0.2
Hair/balding pattern: Pattern 2	2.8	3.6	8.4	-2.0	-2.2	-1.2	-0.5	1.8	-2.1	2.1	2.9	0.2	-2.1	1.9	-2.0
Had menopause	0.7	0.9	2.3	1.0	0.6	1.5	-0.8	-1.3	1.0	-0.5	-1.1	-0.3	1.0	-0.5	0.8
Had other major operations	0.5	0.7	1.4	0.5	0.3	-1.2	-1.1	0.5	0.8	0.7	0.6	-0.5	-1.1	1.1	0.6
Forced vital capacity (FVC)	0.6	2.1	6.2	-1.3	-1.4	-1.7	-1.2	2.5	-1.2	-0.5	2.0	0.2	-1.8	-0.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.0	0.1	0.4	0.1	-0.7	-0.4	0.3	-0.4	-1.0	0.2	0.8	-0.6	-0.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.5	-1.0	-0.7	-0.2	1.6	0.8	-1.0	0.6	-0.1	-0.5	-0.0	0.7	-0.9
Qualifications: None of the above	0.9	1.9	5.2	1.1	1.1	1.1	-1.3	-2.3	1.6	-1.1	-2.1	-0.0	1.5	-1.1	1.2
Financial difficulties in last 2 years	0.3	0.5	1.7	0.3	0.1	0.8	-0.1	-1.0	0.1	0.3	-1.3	0.8	1.2	0.1	0.2
Mouth/teeth dental problems	0.6	0.9	2.4	-0.8	-0.7	-1.6	-0.4	1.3	-0.9	-0.5	0.8	-0.6	-1.3	-1.2	-0.7
Heart attack	0.6	0.8	1.9	0.7	0.7	0.6	0.7	-0.4	0.8	-1.2	-1.0	1.2	0.7	-1.4	0.6
Allergy	1.4	3.3	13.5	-0.9	-0.9	-2.5	-1.3	1.8	-0.9	-0.8	3.1	-1.2	-3.7	-0.5	-0.7
Pain all over the body in last month	0.6	0.6	3.2	-0.5	-1.0	-0.6	-1.8	0.7	-0.4	-0.1	0.7	-0.3	-0.9	0.2	-0.4
Diabetes (self-reported)	1.3	2.0	5.7	0.7	0.4	2.4	1.3	-1.2	0.8	1.3	-1.8	1.5	1.5	1.9	0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	4.1	-0.1	-0.7	2.0	-0.7	0.1	-0.7	0.6	-1.1	1.0	1.0	0.1	-0.2
Medication: Ramipril	0.8	1.0	2.0	-1.4	-1.2	-0.9	-0.8	0.8	-1.2	1.2	0.5	0.5	-0.4	1.2	-1.4
Medication: Simvastatin	0.1	0.1	0.4	-0.0	0.1	-0.5	-0.2	0.0	0.6	0.1	0.2	0.6	-0.5	0.4	-0.1
Fluid intelligence score	0.6	1.2	7.9	-0.3	-0.1	-0.5	1.0	0.8	-0.2	1.9	0.4	-0.5	-0.1	2.8	-0.2
Illnesses of siblings	0.4	0.5	1.8	0.8	1.2	0.3	0.9	0.0	1.3	-0.4	-0.3	0.2	0.6	-0.0	0.8
Neuroticism score	0.5	1.0	2.9	0.6	0.4	1.7	0.6	-0.9	0.6	1.2	-0.8	1.1	1.0	1.7	0.6
Weight	0.2	1.2	3.0	0.9	1.3	-1.4	-0.6	-0.9	1.2	-1.7	-1.7	-0.6	-0.4	-0.6	0.9
Impedance of arm (right)	0.1	0.6	2.1	-0.6	-0.8	1.4	0.1	0.3	-0.9	1.1	0.5	0.7	0.8	0.5	-0.6
Arm fat percentage (right)	0.2	0.7	3.7	0.5	0.6	0.3	-0.8	-1.4	0.5	-0.1	-1.9	-0.5	0.7	0.6	0.4
Trunk fat-free mass	0.3	1.9	6.1	1.2	1.4	-2.1	0.0	-0.4	1.3	-2.5	-0.6	-1.3	-1.4	-1.2	1.2
Hip circumference	0.1	0.3	1.4	-0.5	-0.2	-1.2	-0.7	-0.3	-0.2	-0.1	-1.1	-0.1	-0.3	0.4	-0.5
Time employed in main current job	0.3	0.3	1.4	0.1	-0.1	-0.8	-1.2	0.7	0.3	-0.1	0.7	-0.6	-0.5	0.4	0.2
Alcohol intake versus 10 years previously	0.3	0.5	1.8	0.2	0.1	0.5	0.4	-0.7	-0.1	1.0	-0.6	1.2	-0.1	1.3	0.2
Father’s age at death	0.5	0.6	2.8	-0.3	0.2	0.1	1.7	-0.0	-0.1	1.0	-1.0	1.1	0.7	0.8	-0.3
Worrier / anxious feelings	0.8	1.5	3.4	-1.7	-1.8	0.4	0.6	1.0	-1.8	1.0	1.9	-0.1	-0.2	0.5	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.5	-1.7	-1.2	-1.8	-0.6	1.2	-1.2	-0.3	0.6	-2.1	-0.7	0.2	-1.7
Falls in the last year	0.9	1.3	3.7	1.4	1.5	0.8	0.2	-1.9	1.6	-0.8	-1.0	0.1	0.1	0.3	1.5
Hair/balding pattern: Pattern 3	0.8	1.2	3.1	1.0	0.8	1.8	1.5	-0.8	0.7	-1.1	-1.3	0.2	1.4	-1.1	1.0
Number of live births	1.9	2.7	6.4	1.9	2.4	0.4	2.0	-2.0	2.5	-0.6	-1.6	-0.3	1.2	0.4	1.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.3	-1.1	-1.2	-2.0	-1.3	2.3	-1.1	-1.3	2.1	0.4	-2.3	-1.1	-1.1
Pulse rate	0.5	0.8	3.9	-0.2	-0.6	-0.5	0.2	0.4	-0.5	0.2	1.6	2.0	-1.5	-0.1	-0.1
Happiness	0.8	1.0	4.6	-0.6	-0.8	-0.6	-0.2	0.8	-0.4	2.1	0.8	0.5	-0.2	2.0	-0.5
Noisy workplace	0.3	0.4	1.5	-0.2	-0.4	-0.5	-0.9	1.0	-0.2	-0.1	0.6	-0.5	-1.2	-0.0	-0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.7	-0.8	-0.6	-1.0	1.1	1.6	-1.2	0.5	1.6	1.3	-1.1	-0.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.5	-0.3	-0.1	-1.4	-1.6	0.9	-0.1	-0.4	2.1	-1.6	-2.1	0.0	-0.1
Mouth/teeth dental problems: Dentures	1.2	2.0	3.8	1.7	1.3	1.9	-0.8	-2.0	1.7	-1.0	-1.5	0.3	1.4	-0.7	1.8
Asthma	1.3	2.6	11.6	-0.5	-0.6	2.3	2.0	-1.1	-0.7	1.9	-1.1	1.2	3.4	1.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.1	-1.2	-1.0	-1.6	-0.5	1.8	-1.2	0.5	0.3	0.1	-0.5	1.2	-1.2
Medication: Cholesterol lowering	0.1	0.2	0.6	-0.0	0.1	-0.4	-0.8	0.5	0.5	-0.5	-0.5	0.2	-0.4	-0.5	-0.0
Depression (self-reported)	0.8	0.9	2.6	0.8	1.3	-0.4	-0.2	-0.7	1.0	-1.6	-1.0	-0.9	0.5	-1.4	0.8
Medication: Lansoprazole	0.3	0.3	0.9	0.4	0.4	-0.0	0.8	-0.6	0.9	0.4	0.1	0.9	-0.3	0.7	0.5
Prospective memory result	1.2	1.5	5.3	0.2	0.3	1.6	2.3	-1.3	0.4	0.2	-2.0	0.4	1.9	0.1	0.1
Lung cancer (father)	0.1	0.1	0.8	-0.2	-0.1	-0.2	-0.3	0.9	-0.0	-0.2	0.4	0.3	-0.5	0.1	-0.2
Illnesses of mother	0.6	0.8	2.0	0.7	0.9	-1.3	-0.7	-0.0	0.9	-1.2	-0.1	-0.9	0.0	-1.4	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.7	6.3	-1.2	-1.1	-2.5	-1.2	2.4	-1.1	-1.4	2.0	0.6	-2.4	-1.6	-1.2
Pulse wave Arterial Stiffness index	1.2	1.4	3.9	0.9	1.0	-1.2	-1.4	-0.8	1.0	-1.3	-0.4	-2.0	-1.3	-1.4	1.0
Impedance of arm (left)	0.1	0.6	1.0	-0.9	-0.9	0.9	-0.0	1.0	-1.0	0.7	0.7	0.7	0.6	0.2	-0.9
Arm fat mass (right)	0.2	0.7	3.6	0.5	0.8	-0.7	-0.8	-1.0	0.7	-0.9	-1.9	-0.8	0.1	-0.0	0.4
Trunk predicted mass	0.3	1.8	6.0	1.1	1.4	-2.1	0.0	-0.3	1.2	-2.5	-0.6	-1.3	-1.3	-1.2	1.1
Standing height	0.2	1.6	6.1	0.2	0.7	-2.3	0.1	1.1	0.5	-2.5	0.5	-0.9	-1.5	-1.6	0.3
Length of working week for main job	0.6	0.7	1.6	-0.5	-0.7	1.0	0.4	-0.1	-0.8	1.1	-0.1	1.3	1.1	1.0	-0.6
Exposure to tobacco smoke at home	1.5	1.6	4.0	1.6	1.7	0.1	-0.1	-1.2	2.0	-0.6	-1.7	1.7	0.1	-0.9	1.5
Breastfed as a baby	0.2	0.3	0.8	0.7	0.2	-0.1	-0.9	0.4	0.3	0.2	0.6	-0.6	-0.6	0.2	0.6
Tense / ‘highly strung’	0.1	0.2	0.5	0.5	0.4	0.7	-0.5	-0.6	0.5	0.3	-0.1	-0.2	0.6	0.5	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.9	-0.5	-0.7	0.5	0.1	0.4	-1.0	0.1	0.3	0.5	-0.1	-0.2	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.6	0.2	0.4	-1.2	-0.7	0.4	0.8	-1.1	-0.0	-1.3	-0.5	-0.4	0.1
Birth weight of first child	0.1	0.3	1.3	-0.3	-0.3	0.5	0.3	-0.3	-0.4	0.3	-0.8	-0.0	1.1	-0.2	-0.4
Peak expiratory flow (PEF)	0.5	1.2	3.7	-0.3	-0.2	-1.8	-1.4	1.5	-0.1	-0.6	1.5	0.0	-1.9	-0.7	-0.3
Pulse wave reflection index	2.1	2.6	9.5	-0.4	0.0	-2.5	-1.5	0.5	-0.3	-1.7	0.8	-3.1	-2.1	-2.2	-0.3
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.7	0.9	1.1	1.3	1.6	-1.2	0.9	-0.1	-1.3	0.7	1.3	0.5	0.9
Loud music exposure frequency	0.5	0.5	1.1	0.8	0.9	0.1	0.6	-0.3	1.1	0.5	-1.0	0.7	-0.9	0.7	0.8
Qualifications: O levels/GCSEs or equivalent	3.8	6.0	12.2	-3.2	-3.3	-1.3	0.0	3.2	-3.5	1.9	2.9	1.0	-1.4	1.5	-3.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	3.2	-0.6	-0.6	0.3	0.6	0.4	-0.4	0.8	-0.3	0.0	0.6	1.8	-0.7
Blood clot in the leg (DVT)	3.1	4.0	7.7	2.5	2.7	1.1	-0.1	-2.3	2.8	-1.8	-2.7	-0.4	1.2	-1.2	2.5
Medication: Paracetamol	0.7	1.1	3.6	0.9	0.7	-0.7	-1.9	-0.9	0.8	-0.9	-0.5	-1.8	-0.4	-1.0	0.9
Headache pain in last month	0.3	0.4	2.7	0.2	0.1	-0.4	-0.1	0.7	0.5	0.1	0.3	-1.6	-0.6	1.0	0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	2.2	0.2	0.2	0.7	1.5	-0.6	-0.1	-0.4	-0.1	0.1	0.7	-0.7	0.2
Glaucoma (self-reported)	0.4	0.5	1.9	-0.6	-0.8	0.7	-0.3	0.4	-0.4	0.3	1.1	1.4	0.6	-0.4	-0.7
Gout (self-reported)	0.5	0.7	5.3	-0.3	-0.6	-0.6	-1.3	0.6	-0.2	-0.0	0.2	-2.3	-0.1	-0.5	-0.4
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	4.4	-1.8	-1.8	-0.4	-0.8	0.3	-1.6	1.7	2.1	0.0	0.1	1.3	-1.8
Medication: Amlodipine	0.5	0.7	4.2	-0.2	-0.2	-0.9	-2.0	0.3	-0.4	-0.2	0.6	-0.5	-1.5	0.1	-0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.0	-0.8	-1.2	0.8	0.3	0.0	-0.8	1.3	1.4	0.4	0.6	0.8	-0.8
Birth weight	0.5	1.0	4.2	0.4	0.2	1.2	0.7	-0.6	-0.3	-1.8	0.2	-0.2	1.2	-2.0	0.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.8	-0.4	-0.6	0.6	1.1	0.3	-0.8	0.4	0.7	1.7	-0.2	-0.6	-0.5
High blood pressure (siblings)	0.9	1.3	3.5	-1.3	-1.9	-0.4	-1.1	0.9	-1.7	1.1	0.9	-0.3	-0.7	0.5	-1.4
Forced vital capacity (FVC), Best measure	0.7	2.5	6.0	-1.3	-1.2	-2.3	-1.0	2.5	-1.2	-1.0	2.0	0.3	-2.1	-1.4	-1.2
Body fat percentage	0.1	0.4	2.7	-0.0	0.2	-0.4	-1.1	-0.7	0.4	-0.1	-1.6	-0.3	0.4	0.3	-0.0
Leg fat percentage (right)	0.1	0.4	1.5	-0.5	-0.3	-0.9	-1.2	0.0	-0.1	0.4	-0.8	-0.3	-0.4	0.5	-0.5
Arm fat-free mass (right)	0.4	1.9	7.5	0.6	1.0	-2.7	-0.6	0.2	1.0	-2.4	-0.5	-1.0	-1.7	-1.4	0.7
Exposure to tobacco smoke outside home	0.3	0.4	1.6	0.5	0.3	0.5	-0.4	-0.4	0.9	0.4	0.0	1.3	-0.6	0.8	0.5
Comparative body size at age 10	0.3	0.9	2.9	1.0	0.7	1.7	0.7	-1.5	0.3	0.1	-1.1	0.2	1.3	0.4	0.8
Number of full brothers	0.4	0.5	1.3	0.8	0.2	0.2	-0.7	-0.4	0.3	-1.0	0.5	-0.9	-1.2	-0.4	0.7
Worry too long after embarrassment	0.9	1.5	3.7	1.2	1.2	1.7	1.0	-1.4	1.0	1.4	-0.1	0.8	0.6	1.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	4.4	-1.9	-1.7	-0.3	0.9	1.6	-1.9	1.0	0.2	0.4	-0.2	1.0	-2.1
Wheeze or whistling in the chest in last year	1.0	1.8	3.5	-1.4	-1.3	1.0	1.7	0.3	-1.0	1.9	0.0	1.6	1.6	1.4	-1.6
Number of children fathered	0.3	0.4	2.0	0.4	0.4	-0.2	-0.3	0.0	0.9	-0.6	0.3	0.5	-0.4	-1.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	5.9	-0.5	-0.9	-1.1	-0.4	1.2	-0.7	-0.5	1.9	-0.3	-2.4	-0.6	-0.3
Age at first live birth	0.3	0.6	1.6	-0.1	-0.1	-0.9	0.1	1.0	-0.4	-1.3	0.9	-1.1	-0.6	-0.9	-0.1
Pulse wave peak to peak time	1.1	1.2	3.6	-0.8	-0.8	1.1	1.4	0.7	-0.8	1.2	0.4	1.9	1.3	1.3	-0.8
Health satisfaction	2.6	3.3	10.5	1.4	1.2	2.6	1.2	-2.1	1.3	0.5	-3.2	1.6	2.6	0.8	1.2
Shortness of breath walking on level ground	1.2	1.5	3.2	1.5	1.2	1.5	-0.5	-1.2	1.4	-0.7	-1.8	1.0	1.0	0.1	1.4
Qualifications: College or University degree	0.2	0.8	2.7	-0.4	-0.2	-1.4	1.0	1.2	-0.7	-0.5	1.0	-0.1	-1.6	-0.6	-0.4
Eye problems/disorders: None of the above	0.4	0.4	2.4	-0.4	-0.4	0.5	0.6	-0.5	-0.6	1.5	-0.2	0.8	0.3	0.7	-0.4
Mouth/teeth dental problems: Loose teeth	1.6	1.9	7.8	-0.4	-0.6	1.1	0.8	-0.3	-0.2	2.8	-0.3	2.0	0.6	2.8	-0.6
Emphysema/chronic bronchitis	1.6	1.8	5.2	1.2	1.3	2.0	1.1	-1.5	1.4	-0.3	-1.3	-1.0	2.3	-0.1	1.1
Medication for pain relief, constipation, heartburn	0.4	0.8	2.8	-0.7	-0.6	0.6	1.7	0.4	-0.7	0.9	0.8	1.5	0.2	0.6	-0.6
Neck or shoulder pain in last month	2.1	3.0	11.1	2.0	1.2	3.3	0.2	-2.0	1.4	0.8	-2.1	0.3	2.2	0.8	1.8
Medication: Blood pressure	0.7	1.2	5.0	0.5	0.3	-1.2	-2.2	0.2	0.5	-1.1	0.6	-1.4	-1.8	-0.5	0.5
Angina (self-reported)	0.3	0.4	1.6	-0.3	-0.5	1.3	-0.2	0.0	-0.4	-0.2	-0.7	0.6	0.8	-0.6	-0.3
Migraine (self-reported)	0.5	0.7	3.5	-0.7	-0.7	-0.9	1.0	0.9	-0.5	-0.2	1.9	-0.2	-0.3	-0.1	-0.7
Medication: Ibuprofen	1.6	1.9	4.6	-1.7	-1.4	-1.8	-0.2	2.1	-1.7	1.1	0.6	0.8	-0.6	1.6	-1.7
Medication: Allopurinol	0.6	0.9	3.4	-0.5	-0.4	-1.6	-1.0	0.9	-0.2	-0.8	0.7	-1.8	-0.5	-0.8	-0.5
Medication: Omeprazole	2.5	2.9	5.3	2.1	2.1	1.2	-0.1	-2.3	1.9	-1.8	-1.7	-1.5	1.4	-1.3	2.0
Medication: Seretide 50 evohaler	1.2	1.3	6.7	-0.0	-0.6	2.6	0.5	-1.2	-0.4	1.4	0.1	0.5	2.1	0.7	-0.2
Mean time to correctly identify matches	0.3	0.6	3.7	-0.3	-0.6	0.5	-0.0	0.0	-0.7	-0.6	-0.8	-1.9	0.9	-0.4	-0.3
Heart disease (mother)	0.6	0.7	2.2	1.2	0.8	-0.1	-0.4	-1.2	1.5	-0.4	-0.9	0.1	-0.5	0.2	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	0.7	0.9	0.2	0.5	-0.2	0.7	-1.0	-0.4	1.1	0.9	-1.0	0.8
Whole body fat mass	0.2	0.7	3.0	0.3	0.6	-0.9	-1.1	-0.7	0.8	-1.0	-1.7	-0.5	0.0	-0.1	0.3
Leg fat mass (right)	0.1	0.5	2.0	-0.3	-0.0	-1.4	-1.2	0.0	0.1	-0.6	-1.0	-0.5	-0.7	0.0	-0.2
Arm predicted mass (right)	0.4	1.9	10.1	0.3	0.8	-3.2	-0.4	0.5	0.7	-2.2	-0.2	-1.0	-2.0	-1.0	0.4
Pulse rate, automated reading	0.3	1.1	2.8	1.1	0.9	1.0	1.4	-1.7	0.9	1.2	-0.4	1.2	-0.1	1.0	1.0
Alcohol intake frequency.	0.6	1.4	4.3	0.8	0.7	1.8	-0.3	-2.1	0.8	-0.6	-1.6	-1.1	1.5	-0.3	0.8
Comparative height size at age 10	0.4	2.2	4.9	1.9	2.2	-0.3	0.9	-0.6	2.1	-2.0	-1.7	-0.5	0.2	-1.1	1.9
Number of full sisters	0.1	0.2	1.1	-0.1	-0.3	1.0	0.6	0.3	-0.1	-0.2	-0.2	0.3	0.5	-0.1	-0.1
Suffer from ‘nerves’	0.7	1.2	5.2	0.0	-0.8	2.3	0.2	-0.7	-0.6	1.3	-0.2	1.4	0.9	1.6	-0.1
Overall health rating	1.0	2.1	5.0	1.0	0.8	2.2	0.4	-1.9	1.3	0.8	-2.2	0.3	2.0	1.6	0.9
Chest pain or discomfort	0.2	0.2	0.8	-0.7	-0.6	0.1	0.0	0.3	-0.7	0.4	-0.1	-0.1	0.2	-0.3	-0.9
Had major operations	0.2	0.3	1.9	0.2	-0.1	-0.3	0.1	0.4	-0.1	-0.3	0.9	0.1	-1.4	0.2	0.2
Age at last live birth	0.3	0.4	1.5	0.5	0.5	0.9	0.5	-0.1	0.3	-0.2	-0.6	0.9	1.2	0.1	0.4
Family relationship satisfaction	1.6	2.0	5.2	-1.2	-0.7	1.3	1.1	0.3	-0.7	2.1	0.1	2.2	2.3	1.3	-1.3
Leg pain on walking	1.4	1.8	6.2	1.3	1.0	-0.1	-2.5	-1.3	1.2	-1.4	-0.2	-1.6	-0.7	-1.4	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	3.4	1.8	1.6	1.4	-0.3	-1.4	1.6	0.2	-1.7	-0.3	1.0	0.9	1.8
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.6	-0.0	-0.2	0.3	-0.5	0.0	0.1	-0.7	-0.1	-0.4	-0.5	-0.8	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	3.5	-0.2	0.3	-0.4	1.9	0.5	0.2	-0.2	-1.1	0.5	0.3	-0.2	-0.3
Medication: Aspirin	0.4	0.5	2.2	0.5	0.6	0.1	-1.5	0.1	0.9	-1.1	-0.5	-0.9	-0.3	-0.1	0.5
Supplements: Vitamin C	0.4	0.4	2.0	0.3	-0.1	0.8	-1.0	0.1	-0.3	-1.0	-0.3	-0.4	0.2	-1.4	0.3
Knee pain experienced in last month	0.4	0.7	1.8	1.3	0.9	0.6	-0.5	-0.8	1.0	-0.9	-0.8	0.1	-0.2	-0.4	1.3
Hypertension (Self-reported)	1.8	4.9	25.0	-0.2	-0.6	-2.4	-5.0	0.7	-0.3	-2.1	1.2	-3.3	-2.8	-1.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.8	0.9	0.7	1.1	1.1	-1.3	0.8	-0.5	-1.2	0.4	0.7	-0.3	0.8
Illnesses of father: Heart disease	0.8	1.1	6.4	0.7	0.3	-0.5	-2.5	-0.6	0.4	-0.7	-0.3	-2.1	-0.3	-0.3	0.7
Illnesses of siblings: Diabetes	0.9	1.1	2.8	-1.3	-1.4	-0.8	-0.4	0.9	-1.7	0.4	0.1	1.4	-0.4	0.6	-1.4
Smoking status: Previous	1.1	1.7	3.9	1.8	1.6	1.1	-0.3	-1.6	2.0	0.2	-1.0	1.2	0.8	0.8	1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	5.1	-0.1	-0.0	-0.9	-1.0	1.0	-0.4	-2.1	0.4	-0.9	-0.9	-2.3	-0.1
Whole body fat-free mass	0.3	1.7	5.4	1.2	1.4	-1.9	-0.1	-0.6	1.4	-2.3	-0.9	-1.1	-1.0	-1.1	1.2
Leg fat-free mass (right)	0.3	1.8	5.0	1.5	1.8	-1.1	-0.0	-1.2	1.7	-2.2	-1.5	-0.7	-0.3	-1.0	1.5
Arm fat percentage (left)	0.1	0.5	3.1	0.3	0.5	-0.1	-0.8	-1.0	0.5	-0.1	-1.8	-0.2	0.5	0.6	0.2
Average weekly red wine intake	0.5	0.8	1.9	0.5	0.1	-0.7	-1.4	-0.5	0.1	-1.3	1.0	-0.6	-1.0	-1.4	0.5
Handedness (chirality/laterality): Left-handed	1.9	2.3	3.5	-1.8	-1.7	-0.1	1.5	1.6	-1.9	1.4	1.5	1.6	-0.8	1.3	-1.9
Mood swings	0.1	0.3	0.7	-0.0	0.1	0.7	0.4	-0.3	0.0	0.7	-0.7	0.2	0.9	0.8	-0.0
Loneliness, isolation	1.7	2.4	9.7	1.6	1.7	0.8	0.6	-1.6	2.1	-0.4	-3.1	-0.1	1.5	0.7	1.6
Long-standing illness, disability or infirmity	1.5	2.3	7.2	1.0	0.9	1.9	0.4	-2.2	1.2	0.6	-2.5	0.6	2.7	0.7	0.8
Ever had bowel cancer screening	1.4	1.6	2.5	1.4	1.2	1.4	0.2	-1.4	1.2	-1.1	-1.4	-1.4	1.6	-0.8	1.5
Diabetes diagnosed by doctor	1.1	1.8	4.1	0.7	0.6	1.8	1.7	-1.3	0.9	1.4	-1.6	1.5	1.1	2.0	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.8	0.8	1.0	0.1	1.7	-0.8	1.2	1.0	-1.6	-0.9	0.7	1.7	0.7
Friendships satisfaction	2.0	2.4	4.3	-1.8	-1.6	0.1	1.3	1.6	-1.7	2.1	1.4	1.9	0.0	1.8	-1.7
Qualifications: nursing, teaching	0.3	0.4	3.4	0.1	-0.0	-0.5	0.6	0.6	-0.3	-0.0	0.6	1.8	-0.5	0.2	0.0
Commuting to job workplace: Walk	0.9	1.0	3.5	-0.1	0.2	0.7	1.9	-0.3	-0.5	1.1	-0.5	1.1	1.7	1.3	-0.3
Eye problems/disorders: Cataract	1.3	1.5	3.0	1.5	1.3	1.6	0.0	-0.8	1.6	-1.1	-0.9	0.0	1.7	-0.0	1.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	0.4	0.8	-0.0	1.0	-0.3	0.2	-0.5	-0.5	-0.2	0.9	-0.0	0.3
Medication for cholesterol	0.6	0.9	5.0	-0.3	-0.2	0.8	2.2	0.6	-0.5	1.1	0.3	1.6	0.5	0.5	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.5	-0.1	-0.2	-0.2	0.6	0.1	-0.1	-0.5	-0.6	0.7	0.5	-0.5	-0.2
Back pain experienced in last month	0.2	0.3	0.8	-0.4	-0.4	-0.6	0.5	0.5	-0.6	0.8	-0.3	0.9	0.6	0.7	-0.4
Mineral and other dietary supplements	0.1	0.2	0.6	-0.2	0.2	-0.3	0.5	0.1	0.2	-0.3	-0.3	0.8	0.7	-0.4	-0.3
Breast cancer (self-reported)	0.8	1.0	2.4	-0.7	-0.5	-0.9	-1.5	1.2	-1.2	-0.7	0.9	-1.4	-0.2	-1.0	-0.8
Asthma (self-reported)	1.4	2.8	12.1	-0.4	-0.6	2.6	1.9	-1.3	-0.8	1.9	-1.0	1.4	3.5	1.2	-0.6
Osteoporosis (self-reported)	0.3	0.4	1.5	0.5	0.5	0.3	-0.6	-0.3	0.3	-1.0	-0.6	-0.3	0.3	-1.2	0.5
Osteoarthritis (self-reported)	0.9	1.2	3.6	-0.6	-1.2	-0.1	-1.1	0.2	-0.9	1.9	1.4	-0.2	-1.0	1.7	-0.7
Medication: Aspirin	0.9	1.1	3.3	0.4	0.7	-0.7	-1.8	0.4	1.0	-1.8	-0.3	-1.6	-0.9	-1.0	0.5
Medication: Gliclazide	1.3	1.4	5.6	1.0	1.1	-0.6	-1.3	-0.6	1.3	-1.3	-1.3	-2.4	-0.4	-0.8	1.1
Illnesses of father: None of the above (group 1)	0.6	0.8	4.5	0.7	1.0	-0.1	2.1	-0.2	1.1	-0.8	0.1	0.1	-0.2	-1.0	0.6
Smoking status: Current	1.3	2.1	6.4	1.2	1.7	1.1	0.4	-2.1	1.4	0.2	-2.3	0.7	2.5	0.7	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	5.2	-1.1	-1.5	-1.3	-0.7	1.8	-1.3	0.9	2.3	0.8	-2.2	0.1	-1.1
Whole body water mass	0.3	1.8	5.6	1.2	1.5	-1.9	-0.0	-0.7	1.4	-2.4	-1.1	-1.0	-1.0	-1.1	1.2
Leg predicted mass (right)	0.3	1.8	5.1	1.5	1.7	-1.2	-0.1	-1.1	1.7	-2.3	-1.5	-0.8	-0.4	-0.9	1.5
Arm fat mass (left)	0.1	0.6	3.7	0.3	0.7	-0.7	-0.4	-0.9	0.6	-0.8	-1.9	-0.5	0.2	0.2	0.3
Number of self-reported non-cancer illnesses	0.8	1.4	5.2	0.8	-0.2	2.3	-1.7	-1.7	0.2	0.8	-0.7	-0.7	1.9	0.4	0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.6	0.5	0.1	0.2	0.3	0.2	0.1	0.3	0.0	-0.8	0.3	-0.5	0.5
Miserableness	0.4	0.7	1.6	-0.5	-0.6	1.0	0.9	-0.5	-0.6	1.1	-0.9	0.4	1.2	1.2	-0.5
Guilty feelings	0.3	0.4	3.0	0.3	0.0	-0.2	-1.7	-0.4	0.1	-0.0	1.0	-0.4	-0.8	-0.2	0.2
Wears glasses or contact lenses	0.4	0.5	1.7	0.4	0.2	1.3	-0.2	-0.4	0.3	1.0	-0.7	0.5	1.3	0.8	0.3
Ever taken oral contraceptive pill	0.6	0.6	1.6	-0.9	-0.5	-0.2	1.2	0.6	-0.9	0.6	-0.8	0.5	1.3	0.2	-1.0
Hearing aid user	3.5	3.9	8.1	2.8	2.3	1.6	-0.8	-2.7	2.6	0.3	-2.6	-0.1	1.2	1.2	2.7
Mother’s age at death	0.3	0.3	1.3	0.0	0.1	0.2	-0.8	-1.2	-0.0	-0.4	-0.7	-0.1	0.6	-1.1	0.1
Financial situation satisfaction	0.3	0.3	1.5	-0.0	-0.2	0.0	1.1	-0.3	0.2	1.2	0.6	-0.1	0.1	0.8	0.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.4	0.8	1.1	-0.6	-0.4	-0.3	0.9	-1.6	-0.3	-0.8	0.1	-1.9	1.0
Commuting to job workplace: Public transport	1.4	1.7	3.9	-1.5	-1.7	0.4	0.6	0.9	-2.0	1.3	1.7	1.1	0.1	1.2	-1.6
Eye problems/disorders: Glaucoma	0.5	0.6	3.2	-0.4	-0.8	1.2	0.3	0.3	-0.4	0.8	0.3	1.8	0.8	0.2	-0.5
Medication: Blood pressure	0.4	0.8	6.0	0.1	0.0	-0.7	-2.4	-0.3	0.3	0.1	0.4	-1.2	-0.0	0.9	0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.2	0.3	-0.3	1.1	0.2	-0.1	-0.1	0.5	-0.2	-0.4	0.5	0.5	0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.8	0.7	0.6	1.4	0.8	-1.1	0.5	0.3	-0.6	0.4	0.9	0.3	0.8
High cholesterol (Self-reported)	0.4	0.7	4.5	-0.3	-0.6	-0.8	-2.1	0.0	-0.2	-0.7	0.1	-1.3	-0.4	-1.0	-0.4
Medication: Bendroflumethiazide	0.2	0.3	1.9	0.6	0.6	-0.3	-0.7	-0.0	0.6	0.2	-0.1	-0.1	-0.3	1.4	0.7
Medication: Paracetamol	0.4	0.6	3.1	0.0	-0.1	-1.0	-1.8	-0.3	-0.1	-0.2	0.1	-1.6	-0.5	-0.2	0.0
Medication: Lisinopril	1.8	2.4	5.6	1.6	1.6	1.9	-0.6	-1.8	1.9	-0.7	-2.4	0.3	2.1	-0.1	1.4
Medication: Atorvastatin	1.2	1.5	4.0	1.7	1.5	0.8	-0.6	-0.9	1.6	-1.0	-2.0	-0.6	0.7	-0.4	1.6
Illnesses of father: High blood pressure	1.0	1.2	4.2	-1.3	-1.0	0.1	-0.6	1.3	-1.2	1.2	-0.6	1.0	0.0	2.0	-1.2
Alcohol drinker status: Never	0.4	0.5	1.5	-0.8	-1.2	1.1	-0.3	-0.0	-1.1	0.3	0.1	-0.3	0.8	0.1	-0.8
Ever smoked	1.3	2.3	3.8	1.9	1.6	1.9	0.0	-1.8	1.7	0.2	-1.3	1.3	1.7	1.4	1.8
Basal metabolic rate	0.3	1.7	5.6	1.1	1.5	-1.9	-0.2	-0.7	1.4	-2.4	-1.2	-1.1	-1.0	-1.1	1.1
Leg fat percentage (left)	0.1	0.3	1.4	-0.2	0.0	-0.8	-1.1	-0.3	0.3	0.3	-1.2	-0.3	-0.0	0.5	-0.2
Arm fat-free mass (left)	0.3	1.4	5.6	0.7	1.0	-2.4	-0.2	-0.2	0.9	-2.1	-0.7	-1.2	-1.4	-0.9	0.7
Number of operations (self-reported)	0.3	0.4	1.6	0.5	0.2	-0.8	-0.7	0.2	0.7	0.1	1.0	-0.0	-1.3	0.3	0.6
Average weekly beer plus cider intake	0.4	0.5	1.1	-0.8	-0.7	-0.1	-1.0	-0.1	-0.7	-0.3	0.6	-0.9	0.4	-1.1	-0.9
Irritability	0.3	0.5	2.0	0.1	0.1	-0.6	-1.4	0.3	0.2	-0.9	0.8	-1.2	-0.4	-0.6	0.1
Risk taking	1.2	1.7	4.0	1.5	1.7	-0.8	1.8	-0.3	1.8	-2.0	-0.3	0.3	-0.8	-0.8	1.7
Ever had prostate specific antigen (PSA) test	0.1	0.2	1.2	0.0	0.3	0.1	-0.1	-0.1	0.1	0.6	-0.5	-1.1	-0.1	0.3	0.1
Fractured/broken bones in last 5 years	1.3	1.7	3.9	1.9	2.0	0.2	-0.3	-1.6	1.9	-1.2	-0.6	0.4	-0.1	-1.0	1.9
Age started oral contraceptive pill	1.0	1.3	3.4	1.5	1.7	0.1	0.5	-0.9	1.4	0.4	-1.2	-0.5	0.3	1.8	1.4
Diastolic blood pressure, automated reading	0.2	0.5	1.1	-0.8	-0.7	-0.9	-0.6	0.3	-0.8	-0.7	-0.1	-0.6	-1.0	-0.6	-0.8
Ever depressed for a whole week	0.5	0.7	1.5	0.5	0.5	1.0	1.1	-1.1	0.3	0.7	-1.2	-0.6	0.7	0.9	0.3
Unable to work because of sickness or disability	1.0	1.3	8.6	0.9	0.6	-0.4	-0.8	-1.0	0.9	-1.0	-0.9	-2.9	-0.0	-0.6	0.9
Commuting to job workplace: Cycle	2.7	3.2	6.5	2.1	2.5	-1.4	1.1	-1.2	2.2	-2.1	-0.7	-2.1	-0.5	-2.0	2.1
Myopia	0.3	0.4	1.5	0.2	-0.1	0.9	0.6	-0.4	-0.1	0.5	0.5	0.1	1.2	1.0	0.1
Vascular/heart problems diagnosed by doctor	1.1	3.0	14.4	0.4	0.6	2.2	3.8	-0.8	0.1	1.7	-1.0	2.5	2.3	0.8	0.3
Cholesterol lowering medication	0.2	0.3	1.1	0.7	0.6	0.3	-0.1	-1.1	1.0	-0.1	-0.4	-0.6	0.2	0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	3.5	4.2	7.8	2.6	2.5	1.6	-0.5	-2.8	2.4	-1.8	-1.9	-1.5	1.6	-1.6	2.7
Pain experienced in last month	0.4	0.6	1.8	-1.1	-0.8	-0.6	0.1	0.7	-1.0	0.4	1.3	0.4	-0.7	-0.2	-1.1
Supplements: Calcium	0.2	0.2	1.2	-0.1	0.1	-0.6	-0.6	0.3	-0.3	0.4	0.8	-0.1	-1.1	0.0	-0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.3	-0.3	0.7	-0.8	0.1	-0.1	-0.0	0.0	-0.6	-0.6	0.6	0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.9	0.6	0.7	0.6	0.9	-0.5	0.8	-1.2	-1.0	1.2	0.7	-1.4	0.6
Deep venous thrombosis (DVT) (self-reported)	2.6	3.4	7.1	2.3	2.5	1.1	-0.2	-2.2	2.7	-1.5	-2.5	-0.2	1.2	-0.9	2.4
Heart disease (siblings)	1.2	1.5	5.2	1.2	0.6	2.3	0.9	-1.8	0.7	0.8	-0.9	0.7	1.5	0.5	1.2
Alcohol drinker status: Previous	0.5	0.5	1.0	0.9	0.7	0.3	-0.8	-0.9	0.8	-0.9	-0.3	-0.3	0.6	-0.6	1.0
Pack years of smoking	0.9	1.2	3.3	1.2	1.0	1.3	-0.2	-1.8	1.3	-0.9	-0.9	-0.4	1.4	-0.8	1.2
Impedance of whole body	0.3	1.4	3.2	-1.6	-1.6	-0.2	-0.5	1.8	-1.6	0.9	1.5	0.2	-0.3	-0.0	-1.6
Leg fat mass (left)	0.1	0.5	1.8	-0.0	0.3	-1.2	-1.1	-0.3	0.5	-0.8	-1.4	-0.4	-0.4	-0.1	-0.0
Arm predicted mass (left)	0.3	1.4	4.5	0.9	1.2	-2.1	-0.1	-0.4	1.1	-1.9	-1.0	-1.0	-1.2	-0.6	0.9