Hub : Genes

COPS7A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1756 0.0504 1.9e-05 0.067 NA 0.081 NA 0.097 5.9e-06 NA 6.0e-07 NA 4.7e-08
2 GTEx Nerve Tibial 0.1675 0.0557 2.6e-03 0.131 NA 0.088 NA 0.120 1.6e-09 NA 8.2e-07 NA 7.9e-09
3 YFS Blood 0.1262 0.0290 9.5e-14 0.043 0.044 0.052 0.043 0.043 6.1e-14 3.3e-14 1.8e-16 5.1e-14 5.0e-14
4 TCGA Brain Lower Grade Glioma 0.0594 0.0292 2.4e-03 -0.002 0.009 0.010 NA 0.002 9.1e-01 2.6e-02 2.1e-02 NA 1.7e-01
5 TCGA Stomach Adenocarcinoma 0.1190 0.0640 5.6e-03 0.003 0.002 0.008 NA 0.005 1.9e-01 2.1e-01 8.3e-02 NA 1.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.0 0.1 0.3 -0.1 0.0 -0.2 -0.6 0.0
Bipolar Disorder or Schizophrenia 0.2 0.5 1.6 0.6 1.3 -0.1 -0.6 0.0
Depressed Affect (Nagel 2018) 2.9 6.1 10.5 1.6 1.1 2.8 2.9 3.2
Depression (Nagel 2018) 1.6 2.4 4.5 0.9 0.7 1.6 2.1 1.8
Intelligence (Savage-Jansen 2018) 0.3 1.0 1.6 -1.3 -0.8 0.7 -0.9 -1.1
Neuroticism (Nagel 2018) 2.7 6.5 15.3 -0.3 -0.9 2.9 3.9 2.7
Schizophrenia (2018) 0.3 0.6 1.9 0.9 1.4 0.2 -0.2 0.0
Schizophrenia vs Biploar Disorder 0.3 0.4 1.2 1.1 0.0 0.9 0.1 0.0
Worry (Nagel 2018) 3.2 6.7 13.9 -2.0 -2.7 2.4 3.7 1.6
Alzheimer’s Disease (in mother) 0.7 0.8 2.0 0.6 1.0 -1.4 -0.1 -0.6
Alzheimer’s Disease (in father) 0.3 0.3 1.0 -0.2 0.3 1.0 0.5 -0.3
Alzheimer’s Disease (including proxy) 0.5 0.8 1.8 0.8 1.3 -1.1 -0.0 -0.5
Crohns Disease (2017) 0.6 1.4 4.3 -0.9 -0.8 2.1 1.1 -0.1
Irritable Bowel Disease (IBD) 0.2 0.4 1.1 -0.4 -0.6 1.1 -0.1 -0.4
Ulcerative Colitis (UC) 0.6 1.1 2.3 1.2 0.6 -1.1 -1.5 -0.3
Major Depression (MDD) 0.1 0.1 0.4 0.3 0.6 -0.4 0.0 0.0
Reaction Time 0.8 1.5 3.5 1.6 1.2 0.1 0.3 1.9
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.6 -1.3 -0.7 1.3 -0.8 -0.3
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.2 0.3 0.6 -0.1 -0.4 0.7 0.5 0.8
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.7 2.4 7.1 2.7 1.8 -0.3 0.7 1.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.1 1.5 4.6 -1.0 -0.9 1.2 2.1 -0.0
Coronary Artery Disease (CAD) 0.1 0.1 0.7 -0.9 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.5 0.9 3.0 -0.8 0.0 1.7 0.8 0.2
Mean Putamen Volume 0.3 0.3 0.9 0.5 0.2 -0.2 0.9 0.5
Fasting Glucose 2.7 3.2 7.1 -2.0 -1.6 -0.7 -1.4 -2.7
HbA1C 1.7 1.9 5.9 -1.2 -0.5 -0.9 -1.1 -2.4
HDL Cholesterol 1.1 1.8 3.5 1.8 1.9 -1.2 -1.0 -0.2
LDL Cholesterol 1.1 1.7 4.9 0.2 0.2 -2.2 0.1 -1.9
Lupus 0.2 0.3 0.9 0.5 0.3 -0.5 0.9 -0.3
Neuroticism (2016) 0.4 0.5 1.4 0.2 -0.3 1.2 0.8 0.7
Primary Biliary Cirrhosis 1.4 2.0 3.3 1.4 1.6 -1.4 -1.8 -0.1
Rheumatoid Arthritis 1.0 1.4 1.8 1.3 1.0 1.3 0.7 1.4
Schizophrenia (2014) 1.1 2.5 5.4 1.4 1.8 1.0 1.0 2.3
Triglycerides 1.8 2.9 6.3 -2.3 -2.5 1.0 1.4 -0.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 3.2 -0.3 0.0 0.0 -0.5 -1.8
Ulcerative Colitis 0.5 0.7 3.2 -0.2 0.0 -0.5 -1.8 0.0
Blood Eosinophil Count 0.3 2.3 5.3 -0.7 -1.2 -2.0 2.3 0.7
Blood Platelet Count 1.0 11.2 21.5 -4.6 -4.5 -1.1 3.5 0.4
Blood Red Count 0.4 4.1 11.2 -1.1 -1.1 3.3 1.6 2.2
Blood White Count 0.3 2.5 6.8 -1.6 -1.4 -2.6 1.0 -0.4
Heel T-Score 0.3 2.3 4.3 -2.1 -1.9 0.6 1.7 -0.6
BMI 0.2 1.0 2.1 -0.4 -0.2 -1.1 -1.4 -1.1
Height 0.2 4.2 8.1 1.7 2.5 -0.8 -2.8 -1.7
Waist Hip Ratio (WHR) 1.0 4.3 9.1 -2.7 -3.0 1.7 -1.3 -0.8
Systolic Blood Pressure 1.9 9.4 19.2 -4.4 -4.3 2.2 1.7 -1.1
Smoking Status 0.1 0.3 0.6 -0.7 -0.3 -0.3 -0.7 -0.7
Allergy or Eczema 2.0 5.2 6.6 -1.8 -2.4 2.0 2.5 2.6
Cardiovascular Disease 2.1 6.8 15.0 -3.9 -3.3 0.5 -1.4 -2.5
Hypothyroidism (self reported) 0.2 0.5 1.6 0.5 0.1 0.7 0.6 1.3
Respiratory disease 0.1 0.3 1.4 0.1 0.0 -1.2 0.3 -0.2
Type 2 Diabetes (T2D) (2018) 1.0 1.8 3.0 -1.7 -1.2 -0.8 -1.6 -1.2
Lung FEV1/FVC ratio 0.3 1.6 3.0 -1.7 -1.6 0.6 0.6 -1.1
Lung FVC 1.5 7.8 16.5 0.9 0.4 4.1 2.6 3.8
Neuroticism 2.4 5.9 16.1 -0.7 -1.5 2.3 4.0 2.3
Chronotype (morning person) 0.7 1.5 2.9 1.7 1.5 -1.0 -1.2 -0.4
Hair Pigment 0.2 6.7 14.5 3.7 3.8 -1.7 -1.4 0.6
Tanning 0.1 1.8 3.8 0.3 0.4 -1.9 -1.8 -1.3
Hand grip strength (left) 1.5 3.9 9.1 1.7 2.2 -1.5 -3.0 -0.4
Number of treatments/medications taken 1.5 2.7 4.4 -2.0 -2.1 2.0 0.5 0.9
Average weekly spirits intake 1.3 1.6 3.6 -0.7 -0.3 -1.9 -0.9 -1.8
Sensitivity / hurt feelings 1.7 2.9 8.2 1.6 0.8 1.2 1.3 2.9
Frequency of depressed mood in last 2 weeks 1.9 2.6 3.9 1.4 1.1 1.5 2.0 2.0
Hearing difficulty/problems: Yes 3.6 5.6 10.6 -0.4 -0.8 3.3 2.6 3.1
Relative age of first facial hair 0.5 1.0 2.3 0.3 0.4 1.5 0.8 1.4
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.0 -0.8 -0.3 1.0 -0.0 0.2
Ever used hormone-replacement therapy (HRT) 0.4 0.4 0.8 -0.3 -0.8 0.4 0.9 0.7
Ever had hysterectomy (womb removed) 1.5 1.7 2.3 -1.5 -1.0 -0.9 -1.5 -1.4
Systolic blood pressure, automated reading 2.3 6.6 14.1 -3.6 -3.8 1.4 1.1 -1.6
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.5 -0.3 0.1 -1.2 -1.2 -1.6
Angina 0.8 1.0 2.4 -1.6 -1.3 0.5 0.7 0.5
Medication for hormone replacement therapy 0.2 0.3 0.7 -0.4 -0.8 0.5 0.4 0.0
Vitamin and mineral supplements 0.4 0.5 1.2 -0.1 0.2 -1.1 -0.8 -0.8
Supplements: Zinc 3.6 3.9 9.9 -1.5 -1.4 1.9 3.1 1.3
Medication: Co-codamol 0.3 0.3 1.1 -0.0 -0.0 1.0 0.4 0.5
Medication: Metformin 0.9 1.2 3.5 -1.9 -1.6 -0.2 -0.2 -0.3
Diabetes (father) 1.5 1.9 3.4 1.0 1.6 -1.4 -1.8 -0.8
Diabetes (mother) 1.8 2.3 3.8 -1.9 -1.5 -0.4 -1.3 -1.9
Severe depression (siblings) 0.7 0.8 1.8 -0.5 -0.6 0.5 1.3 1.3
Pack years adult smoking proportion 0.6 1.0 2.8 -0.6 -0.6 0.2 -1.1 -1.7
Impedance of leg (right) 0.2 1.0 3.2 0.5 0.4 -1.8 0.8 -1.0
Leg fat-free mass (left) 0.5 2.8 11.6 0.6 1.2 -0.5 -3.4 -0.4
Trunk fat percentage 0.7 2.7 4.2 1.6 1.7 -2.0 -1.9 -0.7
Hand grip strength (right) 1.6 4.4 9.6 1.9 2.5 -1.7 -3.1 -0.3
Townsend deprivation index at recruitment 1.0 1.4 3.0 -1.7 -1.7 0.9 0.1 -0.3
Current tobacco smoking 0.7 1.1 3.5 -1.2 -0.8 1.9 0.2 0.2
Average weekly fortified wine intake 0.7 0.9 3.3 -0.3 -0.3 1.8 0.3 0.9
Maternal smoking around birth 1.1 1.6 3.8 -1.9 -1.9 -0.5 -0.0 -0.7
Fed-up feelings 2.0 3.7 7.6 0.5 -0.1 2.1 2.8 2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.1 0.0 -0.3 1.3 1.8 1.0
Relative age voice broke 0.1 0.1 0.2 -0.3 -0.1 -0.0 -0.5 -0.5
Taking other prescription medications 0.8 1.2 2.2 -1.3 -1.3 1.5 0.1 0.7
Age when periods started (menarche) 0.8 1.8 4.6 -1.3 -1.3 -1.1 0.1 -2.1
Bilateral oophorectomy (both ovaries removed) 2.2 2.5 4.9 -1.5 -0.7 -1.1 -1.9 -2.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.0 -1.4 -1.3 0.7 0.9 -0.5
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.3 -1.2 -1.0 -0.2 1.0 0.5
Qualifications: CSEs or equivalent 1.5 2.0 4.3 0.2 -0.4 1.4 1.9 2.1
Serious illness, injury or assault to yourself 0.0 0.0 0.1 -0.0 0.3 0.1 0.0 -0.1
High blood pressure 1.8 5.2 12.1 -3.5 -3.1 1.0 -0.0 -1.7
Hayfever, allergic rhinitis or eczema 1.0 2.2 4.4 -1.7 -2.1 0.6 1.2 1.4
Multivitamins +/- minerals 0.0 0.1 0.1 0.3 0.1 0.3 -0.1 -0.2
Stomach or abdominal pain in last month 0.8 1.0 3.8 -0.8 -0.5 -0.4 2.0 0.2
Supplements: Glucosamine 2.3 3.0 6.9 2.3 2.6 -1.5 -0.7 -0.2
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 1.8 1.1 1.4 -0.7 -0.4 0.2
Medication: Atenolol 0.7 0.9 1.9 -1.2 -1.4 0.2 -0.7 -0.8
Medication: Levothyroxine sodium 1.4 2.4 5.8 0.6 0.1 1.8 1.7 2.4
Sitting height 0.5 3.7 11.8 1.4 1.8 -0.7 -3.4 -0.9
Chronic bronchitis/emphysema (father) 1.6 1.9 5.2 -0.9 -0.5 -0.9 -1.6 -2.3
High blood pressure (mother) 1.8 2.5 4.0 -2.0 -1.8 1.4 1.1 1.4
Body mass index (BMI) 0.3 1.3 4.5 -0.4 -0.2 -1.1 -2.1 -1.0
Impedance of leg (left) 0.3 1.2 3.6 0.7 0.7 -1.9 0.7 -1.1
Leg predicted mass (left) 0.5 2.7 11.2 0.6 1.2 -0.5 -3.3 -0.4
Trunk fat mass 0.8 3.3 7.1 1.3 1.6 -2.0 -2.7 -1.1
Waist circumference 0.7 2.5 9.5 -0.8 -0.4 -0.6 -3.1 -1.4
Number of incorrect matches in round 1.4 2.3 5.1 -0.1 -0.8 2.2 2.3 1.0
Past tobacco smoking 0.6 1.2 2.0 0.6 0.4 1.2 1.4 1.4
Alcohol usually taken with meals 1.3 2.1 4.0 1.8 2.0 -0.5 -1.7 0.3
Nervous feelings 3.5 6.5 15.1 -2.3 -2.6 2.0 3.9 1.2
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.2 5.6 -0.6 -1.3 2.3 2.4 1.7
Hearing difficulty/problems with background noise 8.8 14.1 23.3 -3.1 -3.6 4.8 3.8 3.1
Hair/balding pattern: Pattern 2 0.9 1.1 2.4 0.7 0.5 -1.0 -1.5 -1.2
Had menopause 2.0 2.6 5.4 -1.8 -2.3 1.1 1.7 -0.2
Had other major operations 2.0 2.5 5.4 -1.2 -1.1 1.0 2.3 1.7
Forced vital capacity (FVC) 0.8 3.0 5.9 1.8 1.8 1.4 0.7 2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.3 -1.5 -1.4 0.3 1.0 -0.7
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.1 -0.6 -0.6 1.1 0.0 0.6
Qualifications: None of the above 1.3 2.8 4.9 -0.9 -1.2 -1.4 -2.2 -2.2
Financial difficulties in last 2 years 3.4 4.6 10.3 -2.8 -3.2 0.6 -1.3 -1.8
Mouth/teeth dental problems 0.7 1.0 2.2 1.5 1.3 -0.8 -0.7 -0.4
Heart attack 0.3 0.4 0.9 -0.7 -1.0 0.5 -0.3 -0.4
Allergy 0.2 0.6 1.0 0.7 1.0 1.0 -0.0 -0.6
Pain all over the body in last month 0.2 0.2 0.4 -0.1 -0.5 0.7 0.7 0.2
Diabetes (self-reported) 1.7 2.7 5.5 -2.3 -2.0 -0.2 -1.4 -1.5
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.2 0.4 0.1 0.0 0.3 1.1
Medication: Ramipril 3.7 4.8 10.1 -3.2 -3.2 1.6 1.0 -0.7
Medication: Simvastatin 0.3 0.5 1.3 0.4 0.6 -0.7 -1.1 0.2
Fluid intelligence score 0.2 0.5 0.9 -1.0 -0.7 0.9 0.4 -0.1
Illnesses of siblings 0.3 0.4 0.9 0.5 0.5 -0.7 -0.6 -0.9
Neuroticism score 1.7 3.6 8.5 -0.3 -0.9 2.2 2.9 1.9
Weight 0.9 4.3 14.5 0.5 1.1 -1.7 -3.8 -1.6
Impedance of arm (right) 0.8 3.9 9.9 3.1 2.6 -1.2 1.0 0.8
Arm fat percentage (right) 0.5 1.8 4.1 0.9 1.0 -1.7 -2.0 -0.6
Trunk fat-free mass 0.5 2.9 11.9 -1.0 -0.2 0.1 -3.4 -1.2
Hip circumference 0.6 2.7 5.8 1.2 1.7 -1.7 -2.4 -0.7
Time employed in main current job 0.5 0.5 2.0 -0.4 -0.7 -0.3 -0.1 -1.4
Alcohol intake versus 10 years previously 0.1 0.2 0.3 -0.5 -0.6 0.3 0.1 0.6
Father’s age at death 0.5 0.6 2.8 -0.4 -0.1 1.7 0.2 0.5
Worrier / anxious feelings 0.4 0.7 1.6 -0.8 -1.3 -0.6 0.7 -0.6
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 2.6 -0.7 -0.8 1.6 1.6 1.5
Falls in the last year 0.4 0.6 1.3 0.7 0.6 -1.2 -0.5 -0.7
Hair/balding pattern: Pattern 3 0.4 0.6 1.1 0.9 1.1 0.3 -0.4 0.8
Number of live births 1.8 2.5 5.1 -2.3 -1.8 -0.0 -1.0 -1.7
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 3.5 1.1 1.2 1.4 0.6 1.9
Pulse rate 0.1 0.2 0.4 -0.1 0.1 -0.5 -0.6 -0.5
Happiness 1.7 2.0 4.9 -0.2 -0.2 1.7 1.5 2.2
Noisy workplace 0.7 0.8 1.7 -0.8 -1.3 1.1 0.2 0.8
Qualifications: A levels/AS levels or equivalent 1.0 2.2 3.7 1.8 1.9 1.2 0.8 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.4 -0.2 0.3 -0.0 0.7 0.0
Mouth/teeth dental problems: Dentures 0.3 0.5 1.8 -1.3 -0.9 0.2 0.0 0.2
Asthma 0.4 0.8 3.7 -0.2 -0.3 -1.9 -0.3 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.5 0.7 0.1 0.1 0.7 0.6
Medication: Cholesterol lowering 0.4 0.6 1.8 0.6 0.9 -0.6 -1.3 0.1
Depression (self-reported) 0.0 0.0 0.1 -0.1 0.2 0.0 -0.2 -0.2
Medication: Lansoprazole 0.2 0.3 0.9 -0.9 -0.6 0.3 -0.0 0.0
Prospective memory result 0.7 0.9 1.3 1.1 1.0 -1.1 -0.9 -0.4
Lung cancer (father) 1.1 1.3 3.8 0.2 0.4 -1.1 -1.9 -1.2
Illnesses of mother 0.8 1.0 1.9 1.4 1.4 0.5 -1.1 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.3 7.0 2.5 2.7 1.2 0.2 2.5
Pulse wave Arterial Stiffness index 0.2 0.2 0.5 -0.7 -0.7 0.2 0.1 -0.0
Impedance of arm (left) 1.0 4.6 11.5 3.4 2.7 -1.0 1.5 1.0
Arm fat mass (right) 0.6 2.5 8.0 0.3 0.6 -1.7 -2.8 -1.2
Trunk predicted mass 0.5 3.0 12.1 -1.1 -0.3 0.1 -3.5 -1.3
Standing height 0.6 5.6 14.7 1.8 2.6 -1.2 -3.8 -1.4
Length of working week for main job 0.2 0.2 0.7 -0.3 -0.1 -0.8 0.1 -0.4
Exposure to tobacco smoke at home 1.0 1.1 2.1 -1.4 -1.3 0.9 0.7 0.5
Breastfed as a baby 1.8 2.2 6.9 1.2 1.2 2.6 0.1 1.1
Tense / ‘highly strung’ 1.7 2.9 6.4 -2.3 -2.5 1.0 1.3 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 5.0 -0.2 -0.2 2.2 0.8 1.6
Hair/balding pattern: Pattern 4 0.1 0.3 1.3 -0.5 -1.1 0.2 0.2 -0.3
Birth weight of first child 0.3 0.5 1.2 -1.1 -0.7 -0.4 -0.1 -0.9
Peak expiratory flow (PEF) 0.2 0.5 1.1 0.8 1.0 -0.3 -0.6 0.6
Pulse wave reflection index 0.3 0.3 0.6 0.7 0.7 -0.4 -0.4 0.5
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.4 0.3 -0.1 1.2 0.4 1.0
Loud music exposure frequency 0.5 0.5 1.1 0.2 0.6 -1.1 -0.5 0.9
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.1 -0.2 0.6 1.7 0.8 1.5
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 4.4 -2.1 -1.8 0.4 -0.0 -1.2
Blood clot in the leg (DVT) 2.5 3.2 5.1 1.9 2.3 -2.0 -1.9 -0.0
Medication: Paracetamol 0.7 1.1 2.3 1.2 0.9 -1.0 -0.3 1.5
Headache pain in last month 0.2 0.4 0.9 0.5 0.1 1.0 0.4 0.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.6 0.5 0.2 -0.4 1.6 0.8
Glaucoma (self-reported) 0.1 0.1 0.1 0.2 -0.3 -0.0 0.3 0.4
Gout (self-reported) 0.8 1.1 2.6 -0.3 -0.4 -1.0 -1.6 -1.2
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 4.5 0.4 -0.0 1.5 1.8 2.1
Medication: Amlodipine 0.2 0.3 1.5 -0.2 -0.2 1.2 -0.0 0.2
Medication: Ventolin 100micrograms inhaler 1.9 2.4 4.8 1.3 1.4 -2.2 -1.8 -0.6
Birth weight 0.8 1.7 4.4 0.3 0.9 -0.8 -2.1 -1.6
Chronic bronchitis/emphysema (mother) 1.9 2.2 4.5 -0.1 0.2 -1.9 -2.1 -1.7
High blood pressure (siblings) 1.7 2.5 5.7 -0.5 -0.6 1.7 2.4 1.9
Forced vital capacity (FVC), Best measure 1.7 6.1 10.9 3.2 3.3 1.0 0.0 2.9
Body fat percentage 0.6 2.3 4.7 1.0 1.2 -2.2 -1.8 -1.1
Leg fat percentage (right) 0.6 2.1 5.3 0.3 0.5 -2.3 -1.8 -1.3
Arm fat-free mass (right) 0.7 3.4 10.9 -1.5 -0.7 -0.4 -3.3 -1.7
Exposure to tobacco smoke outside home 2.9 3.8 6.5 -2.4 -2.5 2.2 1.5 0.0
Comparative body size at age 10 0.3 0.9 1.9 0.8 1.0 -0.4 -1.4 -1.0
Number of full brothers 0.3 0.4 0.7 -0.8 -0.7 0.7 0.7 0.1
Worry too long after embarrassment 1.6 2.7 6.9 -1.7 -1.7 0.9 2.6 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.2 -0.5 -0.2 1.5 0.8 1.3
Wheeze or whistling in the chest in last year 1.3 2.3 4.6 -0.8 -0.2 -1.9 -1.5 -2.1
Number of children fathered 0.8 1.0 1.7 -1.3 -1.0 1.0 0.0 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.9 -0.7 -1.0 1.4 0.5 1.0
Age at first live birth 4.3 7.6 17.1 4.1 4.1 -1.7 -1.0 0.6
Pulse wave peak to peak time 0.4 0.5 1.1 1.0 1.1 -0.1 -0.4 0.2
Health satisfaction 0.2 0.2 0.8 -0.4 -0.1 -0.2 -0.9 0.2
Shortness of breath walking on level ground 0.5 0.6 2.2 -0.7 -0.4 -0.1 -1.5 -0.3
Qualifications: College or University degree 0.2 0.7 1.6 0.9 1.3 -0.5 0.7 0.6
Eye problems/disorders: None of the above 2.3 2.6 5.4 2.3 2.3 -0.9 -1.0 0.9
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.6 -0.2 -0.4 1.3 0.2 -0.1
Emphysema/chronic bronchitis 1.1 1.3 1.9 -1.4 -1.1 -1.2 -0.0 -1.4
Medication for pain relief, constipation, heartburn 0.2 0.3 0.8 0.4 0.4 0.3 0.2 -0.9
Neck or shoulder pain in last month 3.6 5.2 12.0 -0.5 -1.1 2.6 3.5 2.4
Medication: Blood pressure 0.8 1.5 2.9 -1.7 -1.5 1.2 -0.3 -0.8
Angina (self-reported) 1.0 1.3 2.5 -1.6 -1.4 0.8 0.9 0.7
Migraine (self-reported) 0.4 0.5 0.8 -0.4 -0.7 0.9 0.4 0.8
Medication: Ibuprofen 0.2 0.3 0.8 0.9 0.4 -0.3 0.6 0.3
Medication: Allopurinol 0.2 0.2 0.4 -0.2 -0.6 0.2 -0.7 -0.6
Medication: Omeprazole 3.8 4.5 9.2 -3.0 -2.7 1.7 1.7 -0.2
Medication: Seretide 50 evohaler 4.3 4.9 8.4 1.8 2.1 -2.9 -2.4 -1.7
Mean time to correctly identify matches 0.9 1.7 4.0 1.1 0.4 1.2 1.4 2.0
Heart disease (mother) 0.2 0.3 0.6 -0.7 -0.7 -0.0 0.4 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 2.8 -1.4 -1.5 -1.0 -1.3 -1.7
Whole body fat mass 0.7 3.1 7.1 1.0 1.3 -2.0 -2.7 -1.2
Leg fat mass (right) 0.7 2.8 7.8 0.1 0.5 -1.9 -2.8 -1.5
Arm predicted mass (right) 0.7 3.4 12.1 -1.3 -0.4 -0.3 -3.5 -1.7
Pulse rate, automated reading 0.5 1.7 4.1 -2.0 -1.7 0.5 -0.5 -1.1
Alcohol intake frequency. 0.4 1.0 3.2 0.1 0.0 1.8 0.2 1.3
Comparative height size at age 10 1.7 9.5 31.2 1.6 2.3 -2.0 -5.6 -2.2
Number of full sisters 2.5 3.0 6.4 -1.3 -0.9 -1.5 -2.0 -2.5
Suffer from ‘nerves’ 2.8 4.5 6.5 -1.7 -2.2 2.3 2.6 1.7
Overall health rating 1.4 3.0 7.9 -2.8 -2.5 0.4 0.7 -0.2
Chest pain or discomfort 2.0 2.9 5.7 -2.2 -1.6 -1.2 -0.0 -2.4
Had major operations 0.5 0.6 1.1 0.7 1.1 0.5 -0.5 1.0
Age at last live birth 1.1 1.5 4.0 1.6 2.0 -1.0 -0.2 0.3
Family relationship satisfaction 0.3 0.4 1.5 -0.3 -0.4 0.1 1.2 0.5
Leg pain on walking 1.0 1.3 3.4 -0.4 -0.4 1.2 1.1 1.9
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.8 0.9 0.7 1.7 1.0 1.2
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.2 1.1 1.0 -0.6 -0.4 -0.1
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.3 1.5 1.3 -0.5 0.3 0.6
Medication: Aspirin 0.7 0.9 3.0 -0.8 -0.7 0.1 -1.7 -0.7
Supplements: Vitamin C 1.0 1.2 3.5 -0.6 -0.5 0.6 1.9 1.3
Knee pain experienced in last month 0.5 0.7 1.9 0.5 0.4 -0.1 1.2 1.4
Hypertension (Self-reported) 2.1 6.0 14.0 -3.7 -3.3 1.1 -0.2 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 2.0 -1.4 -1.4 1.0 1.0 0.1
Illnesses of father: Heart disease 0.8 1.1 2.7 -1.6 -1.2 0.7 0.9 -0.4
Illnesses of siblings: Diabetes 0.7 0.9 2.4 0.8 0.7 0.7 -0.7 1.6
Smoking status: Previous 1.0 1.6 2.4 -1.0 -1.0 -1.4 -1.2 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 3.9 1.6 2.0 -1.5 -1.7 0.1
Whole body fat-free mass 0.5 2.6 11.6 -0.7 0.1 -0.1 -3.4 -1.1
Leg fat-free mass (right) 0.5 2.8 11.7 0.6 1.2 -0.5 -3.4 -0.5
Arm fat percentage (left) 0.4 1.4 2.6 1.0 1.0 -1.6 -1.6 -0.4
Average weekly red wine intake 1.3 1.9 4.5 -0.3 0.6 -0.7 -2.1 -2.1
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.6 1.6 0.9 -0.4 -0.3 1.1
Mood swings 4.3 7.8 13.0 2.9 2.1 1.6 3.3 3.6
Loneliness, isolation 0.9 1.3 2.5 1.6 1.4 0.4 -1.3 0.4
Long-standing illness, disability or infirmity 1.1 1.7 3.2 -1.1 -1.3 1.0 1.8 1.1
Ever had bowel cancer screening 0.5 0.5 1.5 -0.5 0.3 -1.2 -0.6 -0.7
Diabetes diagnosed by doctor 1.7 2.8 4.9 -2.2 -1.9 -0.8 -1.6 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.8 0.1 0.1 0.9 0.4 0.2
Friendships satisfaction 0.2 0.3 0.7 -0.8 -0.7 -0.3 0.5 0.1
Qualifications: nursing, teaching 3.2 5.0 13.5 3.1 3.7 0.5 -0.6 1.1
Commuting to job workplace: Walk 0.4 0.4 1.5 -1.2 -0.5 0.7 -0.0 -0.2
Eye problems/disorders: Cataract 2.1 2.4 3.8 -1.8 -1.9 1.3 1.8 0.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.4 0.9 1.0 0.5 0.7 1.2
Medication for cholesterol 1.2 1.8 2.7 1.3 1.2 1.2 1.6 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 3.3 -1.4 -1.4 0.5 1.8 0.9
Back pain experienced in last month 0.4 0.5 1.3 -0.8 -0.7 0.3 1.1 0.3
Mineral and other dietary supplements 0.1 0.2 0.5 -0.2 0.1 -0.6 -0.7 -0.1
Breast cancer (self-reported) 1.4 1.7 4.4 -1.3 -1.0 -1.0 -0.5 -2.1
Asthma (self-reported) 0.5 0.9 3.7 -0.0 -0.2 -1.9 -0.7 -0.7
Osteoporosis (self-reported) 0.3 0.4 0.9 0.9 0.9 -0.7 -0.1 0.2
Osteoarthritis (self-reported) 0.7 0.9 2.4 0.8 0.8 0.6 0.8 1.5
Medication: Aspirin 0.4 0.6 1.2 -0.8 -0.7 0.5 -1.1 -0.4
Medication: Gliclazide 2.9 3.2 6.8 -2.6 -2.1 -1.5 -0.8 -1.4
Illnesses of father: None of the above (group 1) 0.3 0.4 0.6 0.7 0.6 -0.8 -0.5 0.1
Smoking status: Current 0.7 1.1 3.8 -1.0 -0.5 1.9 0.3 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 5.9 1.7 1.3 1.6 1.7 2.4
Whole body water mass 0.5 2.7 11.4 -0.8 -0.0 -0.1 -3.4 -1.1
Leg predicted mass (right) 0.5 2.5 10.6 0.5 1.2 -0.4 -3.3 -0.4
Arm fat mass (left) 0.5 2.1 6.4 0.5 0.8 -1.6 -2.5 -1.0
Number of self-reported non-cancer illnesses 0.3 0.6 1.7 -0.6 -0.5 0.8 0.1 1.3
Average weekly champagne plus white wine intake 0.4 0.6 1.3 0.5 0.8 -1.2 -0.7 -0.3
Miserableness 3.0 5.2 6.8 2.1 1.6 2.5 2.4 2.6
Guilty feelings 0.2 0.3 0.7 -0.5 -0.5 -0.1 0.9 0.6
Wears glasses or contact lenses 1.1 1.3 3.2 -0.1 -0.3 1.2 1.8 1.3
Ever taken oral contraceptive pill 0.3 0.3 1.1 -0.5 -0.5 1.0 -0.1 -0.0
Hearing aid user 0.7 0.7 1.6 1.2 1.3 -0.3 -0.7 0.2
Mother’s age at death 0.2 0.3 0.8 -0.1 0.2 -0.5 -0.9 -0.5
Financial situation satisfaction 2.8 3.5 5.5 -2.2 -2.4 2.2 1.1 0.7
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.8 -0.9 -1.1 1.4 0.8 0.1
Commuting to job workplace: Public transport 0.6 0.7 1.4 -0.2 -0.0 -1.1 -0.9 -1.2
Eye problems/disorders: Glaucoma 0.3 0.4 0.9 0.9 0.7 -0.7 -0.0 0.3
Medication: Blood pressure 0.9 1.6 3.8 -1.8 -1.9 0.6 -0.2 -0.8
Pain type(s) experienced in last month: Hip pain 1.8 2.3 4.5 2.1 1.6 -0.0 0.8 1.9
Supplements: Fish oil (including cod liver oil) 0.3 0.3 1.3 0.2 0.1 0.3 1.1 0.5
High cholesterol (Self-reported) 0.8 1.4 3.3 -0.1 0.3 -1.7 -1.8 -1.0
Medication: Bendroflumethiazide 1.2 1.9 5.5 -0.7 -0.5 -0.8 -1.6 -2.3
Medication: Paracetamol 1.0 1.6 5.0 1.2 0.8 -0.4 0.8 2.2
Medication: Lisinopril 0.9 1.2 2.1 -0.8 -0.4 -1.0 -1.4 -1.4
Medication: Atorvastatin 0.8 1.0 2.2 -1.0 -1.3 0.1 1.5 0.2
Illnesses of father: High blood pressure 0.2 0.3 1.0 -0.4 -0.5 -0.0 0.4 1.0
Alcohol drinker status: Never 0.1 0.1 0.3 0.3 0.5 0.1 0.2 0.1
Ever smoked 0.5 0.8 1.9 -0.4 -0.1 -0.5 -1.4 -1.3
Basal metabolic rate 0.6 3.1 13.6 -0.2 0.5 -0.6 -3.7 -1.1
Leg fat percentage (left) 0.7 2.4 5.7 0.4 0.6 -2.4 -1.9 -1.4
Arm fat-free mass (left) 0.6 3.0 11.0 -1.3 -0.4 -0.1 -3.3 -1.4
Number of operations (self-reported) 1.4 2.1 5.7 -2.4 -2.1 0.4 0.4 -0.1
Average weekly beer plus cider intake 1.7 2.5 5.6 -2.0 -2.4 -0.4 0.6 -1.5
Irritability 1.2 2.1 4.2 0.8 0.1 2.0 1.9 1.4
Risk taking 0.7 1.0 2.3 0.6 1.5 -0.8 -0.7 -1.2
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.9 -0.9 -0.5 0.0 0.7 0.1
Fractured/broken bones in last 5 years 1.1 1.4 3.2 -1.3 -1.4 0.1 -1.8 -0.2
Age started oral contraceptive pill 1.2 1.6 4.3 -0.1 -0.2 1.2 2.1 1.4
Diastolic blood pressure, automated reading 1.6 5.1 10.8 -3.3 -3.3 1.2 1.2 -1.1
Ever depressed for a whole week 0.4 0.5 1.4 -0.1 -0.2 0.6 -0.8 1.2
Unable to work because of sickness or disability 1.1 1.4 3.8 -2.0 -1.8 -0.0 -0.1 -0.3
Commuting to job workplace: Cycle 0.7 0.8 1.2 0.8 0.8 1.1 0.7 1.0
Myopia 1.2 1.8 4.0 0.1 -0.3 1.5 1.6 2.0
Vascular/heart problems diagnosed by doctor 1.7 4.6 10.7 3.3 3.0 -0.8 0.1 1.6
Cholesterol lowering medication 0.2 0.3 0.7 -0.5 -0.4 -0.8 -0.5 0.3
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 3.7 -1.9 -1.2 1.4 1.1 0.2
Pain experienced in last month 1.3 2.2 5.2 0.9 1.3 -1.1 -2.3 -1.4
Supplements: Calcium 1.1 1.2 4.6 -0.4 -0.2 0.6 2.1 1.0
Basal cell carcinoma (self-reported) 2.2 2.6 5.8 -2.4 -2.0 1.2 -0.2 -1.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.9 -0.7 -1.0 0.5 -0.5 -0.4
Deep venous thrombosis (DVT) (self-reported) 3.4 4.3 6.6 2.0 2.4 -2.6 -2.2 -0.2
Heart disease (siblings) 1.1 1.4 2.9 0.7 1.1 -1.4 -1.7 -0.5
Alcohol drinker status: Previous 1.1 1.2 2.5 -1.6 -1.1 1.4 -0.1 -0.5
Pack years of smoking 0.5 0.7 2.2 -0.2 -0.2 -0.0 -1.1 -1.5
Impedance of whole body 0.5 2.8 5.9 2.4 2.0 -1.5 1.2 0.1
Leg fat mass (left) 0.8 3.0 8.6 0.0 0.5 -1.9 -2.9 -1.6
Arm predicted mass (left) 0.7 3.4 12.5 -1.4 -0.4 -0.3 -3.5 -1.5