TWAS hub - COPS7A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1756	0.0504	1.9e-05	0.067	NA	0.081	NA	0.097	5.9e-06	NA	6.0e-07	NA	4.7e-08
2	GTEx	Nerve Tibial	0.1675	0.0557	2.6e-03	0.131	NA	0.088	NA	0.120	1.6e-09	NA	8.2e-07	NA	7.9e-09
3	YFS	Blood	0.1262	0.0290	9.5e-14	0.043	0.044	0.052	0.043	0.043	6.1e-14	3.3e-14	1.8e-16	5.1e-14	5.0e-14
4	TCGA	Brain Lower Grade Glioma	0.0594	0.0292	2.4e-03	-0.002	0.009	0.010	NA	0.002	9.1e-01	2.6e-02	2.1e-02	NA	1.7e-01
5	TCGA	Stomach Adenocarcinoma	0.1190	0.0640	5.6e-03	0.003	0.002	0.008	NA	0.005	1.9e-01	2.1e-01	8.3e-02	NA	1.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Hearing difficulty/problems with background noise	8.8	14.1	23.3	-3.1	-3.6	4.8	3.8	3.1
Age at first live birth	4.3	7.6	17.1	4.1	4.1	-1.7	-1.0	0.6
Medication: Seretide 50 evohaler	4.3	4.9	8.4	1.8	2.1	-2.9	-2.4	-1.7
Mood swings	4.3	7.8	13.0	2.9	2.1	1.6	3.3	3.6
Medication: Omeprazole	3.8	4.5	9.2	-3.0	-2.7	1.7	1.7	-0.2
Medication: Ramipril	3.7	4.8	10.1	-3.2	-3.2	1.6	1.0	-0.7
Hearing difficulty/problems: Yes	3.6	5.6	10.6	-0.4	-0.8	3.3	2.6	3.1
Supplements: Zinc	3.6	3.9	9.9	-1.5	-1.4	1.9	3.1	1.3
Neck or shoulder pain in last month	3.6	5.2	12.0	-0.5	-1.1	2.6	3.5	2.4
Nervous feelings	3.5	6.5	15.1	-2.3	-2.6	2.0	3.9	1.2
Financial difficulties in last 2 years	3.4	4.6	10.3	-2.8	-3.2	0.6	-1.3	-1.8
Deep venous thrombosis (DVT) (self-reported)	3.4	4.3	6.6	2.0	2.4	-2.6	-2.2	-0.2
Worry (Nagel 2018)	3.2	6.7	13.9	-2.0	-2.7	2.4	3.7	1.6
Qualifications: nursing, teaching	3.2	5.0	13.5	3.1	3.7	0.5	-0.6	1.1
Miserableness	3.0	5.2	6.8	2.1	1.6	2.5	2.4	2.6
Depressed Affect (Nagel 2018)	2.9	6.1	10.5	1.6	1.1	2.8	2.9	3.2
Exposure to tobacco smoke outside home	2.9	3.8	6.5	-2.4	-2.5	2.2	1.5	0.0
Medication: Gliclazide	2.9	3.2	6.8	-2.6	-2.1	-1.5	-0.8	-1.4
Suffer from ‘nerves’	2.8	4.5	6.5	-1.7	-2.2	2.3	2.6	1.7
Financial situation satisfaction	2.8	3.5	5.5	-2.2	-2.4	2.2	1.1	0.7
Neuroticism (Nagel 2018)	2.7	6.5	15.3	-0.3	-0.9	2.9	3.9	2.7
Fasting Glucose	2.7	3.2	7.1	-2.0	-1.6	-0.7	-1.4	-2.7
Blood clot in the leg (DVT)	2.5	3.2	5.1	1.9	2.3	-2.0	-1.9	-0.0
Number of full sisters	2.5	3.0	6.4	-1.3	-0.9	-1.5	-2.0	-2.5
Neuroticism	2.4	5.9	16.1	-0.7	-1.5	2.3	4.0	2.3
Systolic blood pressure, automated reading	2.3	6.6	14.1	-3.6	-3.8	1.4	1.1	-1.6
Supplements: Glucosamine	2.3	3.0	6.9	2.3	2.6	-1.5	-0.7	-0.2
Eye problems/disorders: None of the above	2.3	2.6	5.4	2.3	2.3	-0.9	-1.0	0.9
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	4.9	-1.5	-0.7	-1.1	-1.9	-2.2
Basal cell carcinoma (self-reported)	2.2	2.6	5.8	-2.4	-2.0	1.2	-0.2	-1.3
Cardiovascular Disease	2.1	6.8	15.0	-3.9	-3.3	0.5	-1.4	-2.5
Hypertension (Self-reported)	2.1	6.0	14.0	-3.7	-3.3	1.1	-0.2	-1.9
Eye problems/disorders: Cataract	2.1	2.4	3.8	-1.8	-1.9	1.3	1.8	0.2
Allergy or Eczema	2.0	5.2	6.6	-1.8	-2.4	2.0	2.5	2.6
Fed-up feelings	2.0	3.7	7.6	0.5	-0.1	2.1	2.8	2.5
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	5.6	-0.6	-1.3	2.3	2.4	1.7
Had menopause	2.0	2.6	5.4	-1.8	-2.3	1.1	1.7	-0.2
Had other major operations	2.0	2.5	5.4	-1.2	-1.1	1.0	2.3	1.7
Chest pain or discomfort	2.0	2.9	5.7	-2.2	-1.6	-1.2	-0.0	-2.4
Systolic Blood Pressure	1.9	9.4	19.2	-4.4	-4.3	2.2	1.7	-1.1
Frequency of depressed mood in last 2 weeks	1.9	2.6	3.9	1.4	1.1	1.5	2.0	2.0
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.8	1.3	1.4	-2.2	-1.8	-0.6
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.5	-0.1	0.2	-1.9	-2.1	-1.7
Triglycerides	1.8	2.9	6.3	-2.3	-2.5	1.0	1.4	-0.3
Diabetes (mother)	1.8	2.3	3.8	-1.9	-1.5	-0.4	-1.3	-1.9
High blood pressure	1.8	5.2	12.1	-3.5	-3.1	1.0	-0.0	-1.7
High blood pressure (mother)	1.8	2.5	4.0	-2.0	-1.8	1.4	1.1	1.4
Number of live births	1.8	2.5	5.1	-2.3	-1.8	-0.0	-1.0	-1.7
Breastfed as a baby	1.8	2.2	6.9	1.2	1.2	2.6	0.1	1.1
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.5	2.1	1.6	-0.0	0.8	1.9
Age at First Birth	1.7	2.4	7.1	2.7	1.8	-0.3	0.7	1.1
HbA1C	1.7	1.9	5.9	-1.2	-0.5	-0.9	-1.1	-2.4
Sensitivity / hurt feelings	1.7	2.9	8.2	1.6	0.8	1.2	1.3	2.9
Diabetes (self-reported)	1.7	2.7	5.5	-2.3	-2.0	-0.2	-1.4	-1.5
Neuroticism score	1.7	3.6	8.5	-0.3	-0.9	2.2	2.9	1.9
Happiness	1.7	2.0	4.9	-0.2	-0.2	1.7	1.5	2.2
Tense / ‘highly strung’	1.7	2.9	6.4	-2.3	-2.5	1.0	1.3	-0.3
High blood pressure (siblings)	1.7	2.5	5.7	-0.5	-0.6	1.7	2.4	1.9
Forced vital capacity (FVC), Best measure	1.7	6.1	10.9	3.2	3.3	1.0	0.0	2.9
Comparative height size at age 10	1.7	9.5	31.2	1.6	2.3	-2.0	-5.6	-2.2
Diabetes diagnosed by doctor	1.7	2.8	4.9	-2.2	-1.9	-0.8	-1.6	-1.5
Average weekly beer plus cider intake	1.7	2.5	5.6	-2.0	-2.4	-0.4	0.6	-1.5
Vascular/heart problems diagnosed by doctor	1.7	4.6	10.7	3.3	3.0	-0.8	0.1	1.6
Depression (Nagel 2018)	1.6	2.4	4.5	0.9	0.7	1.6	2.1	1.8
Hand grip strength (right)	1.6	4.4	9.6	1.9	2.5	-1.7	-3.1	-0.3
Chronic bronchitis/emphysema (father)	1.6	1.9	5.2	-0.9	-0.5	-0.9	-1.6	-2.3
Worry too long after embarrassment	1.6	2.7	6.9	-1.7	-1.7	0.9	2.6	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	2.8	-1.4	-1.5	-1.0	-1.3	-1.7
Diastolic blood pressure, automated reading	1.6	5.1	10.8	-3.3	-3.3	1.2	1.2	-1.1
Lung FVC	1.5	7.8	16.5	0.9	0.4	4.1	2.6	3.8
Hand grip strength (left)	1.5	3.9	9.1	1.7	2.2	-1.5	-3.0	-0.4
Number of treatments/medications taken	1.5	2.7	4.4	-2.0	-2.1	2.0	0.5	0.9
Ever had hysterectomy (womb removed)	1.5	1.7	2.3	-1.5	-1.0	-0.9	-1.5	-1.4
Diabetes (father)	1.5	1.9	3.4	1.0	1.6	-1.4	-1.8	-0.8
Qualifications: CSEs or equivalent	1.5	2.0	4.3	0.2	-0.4	1.4	1.9	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	5.9	1.7	1.3	1.6	1.7	2.4
Primary Biliary Cirrhosis	1.4	2.0	3.3	1.4	1.6	-1.4	-1.8	-0.1
Medication: Levothyroxine sodium	1.4	2.4	5.8	0.6	0.1	1.8	1.7	2.4
Number of incorrect matches in round	1.4	2.3	5.1	-0.1	-0.8	2.2	2.3	1.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.4	-2.1	-1.8	0.4	-0.0	-1.2
Overall health rating	1.4	3.0	7.9	-2.8	-2.5	0.4	0.7	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.3	-1.4	-1.4	0.5	1.8	0.9
Breast cancer (self-reported)	1.4	1.7	4.4	-1.3	-1.0	-1.0	-0.5	-2.1
Number of operations (self-reported)	1.4	2.1	5.7	-2.4	-2.1	0.4	0.4	-0.1
Average weekly spirits intake	1.3	1.6	3.6	-0.7	-0.3	-1.9	-0.9	-1.8
Alcohol usually taken with meals	1.3	2.1	4.0	1.8	2.0	-0.5	-1.7	0.3
Qualifications: None of the above	1.3	2.8	4.9	-0.9	-1.2	-1.4	-2.2	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	7.0	2.5	2.7	1.2	0.2	2.5
Wheeze or whistling in the chest in last year	1.3	2.3	4.6	-0.8	-0.2	-1.9	-1.5	-2.1
Average weekly red wine intake	1.3	1.9	4.5	-0.3	0.6	-0.7	-2.1	-2.1
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.7	-1.9	-1.2	1.4	1.1	0.2
Pain experienced in last month	1.3	2.2	5.2	0.9	1.3	-1.1	-2.3	-1.4
Medication for cholesterol	1.2	1.8	2.7	1.3	1.2	1.2	1.6	1.4
Medication: Bendroflumethiazide	1.2	1.9	5.5	-0.7	-0.5	-0.8	-1.6	-2.3
Irritability	1.2	2.1	4.2	0.8	0.1	2.0	1.9	1.4
Age started oral contraceptive pill	1.2	1.6	4.3	-0.1	-0.2	1.2	2.1	1.4
Myopia	1.2	1.8	4.0	0.1	-0.3	1.5	1.6	2.0
Body Mass Index (BMI) (2010)	1.1	1.5	4.6	-1.0	-0.9	1.2	2.1	-0.0
HDL Cholesterol	1.1	1.8	3.5	1.8	1.9	-1.2	-1.0	-0.2
LDL Cholesterol	1.1	1.7	4.9	0.2	0.2	-2.2	0.1	-1.9
Schizophrenia (2014)	1.1	2.5	5.4	1.4	1.8	1.0	1.0	2.3
Maternal smoking around birth	1.1	1.6	3.8	-1.9	-1.9	-0.5	-0.0	-0.7
Lung cancer (father)	1.1	1.3	3.8	0.2	0.4	-1.1	-1.9	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.0	-0.2	-0.2	2.2	0.8	1.6
Emphysema/chronic bronchitis	1.1	1.3	1.9	-1.4	-1.1	-1.2	-0.0	-1.4
Age at last live birth	1.1	1.5	4.0	1.6	2.0	-1.0	-0.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.8	0.9	0.7	1.7	1.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	3.9	1.6	2.0	-1.5	-1.7	0.1
Long-standing illness, disability or infirmity	1.1	1.7	3.2	-1.1	-1.3	1.0	1.8	1.1
Wears glasses or contact lenses	1.1	1.3	3.2	-0.1	-0.3	1.2	1.8	1.3
Fractured/broken bones in last 5 years	1.1	1.4	3.2	-1.3	-1.4	0.1	-1.8	-0.2
Unable to work because of sickness or disability	1.1	1.4	3.8	-2.0	-1.8	-0.0	-0.1	-0.3
Supplements: Calcium	1.1	1.2	4.6	-0.4	-0.2	0.6	2.1	1.0
Heart disease (siblings)	1.1	1.4	2.9	0.7	1.1	-1.4	-1.7	-0.5
Alcohol drinker status: Previous	1.1	1.2	2.5	-1.6	-1.1	1.4	-0.1	-0.5
Rheumatoid Arthritis	1.0	1.4	1.8	1.3	1.0	1.3	0.7	1.4
Blood Platelet Count	1.0	11.2	21.5	-4.6	-4.5	-1.1	3.5	0.4
Waist Hip Ratio (WHR)	1.0	4.3	9.1	-2.7	-3.0	1.7	-1.3	-0.8
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.0	-1.7	-1.2	-0.8	-1.6	-1.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.5	-0.3	0.1	-1.2	-1.2	-1.6
Townsend deprivation index at recruitment	1.0	1.4	3.0	-1.7	-1.7	0.9	0.1	-0.3
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.4	-1.7	-2.1	0.6	1.2	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.6	-0.7	-0.8	1.6	1.6	1.5
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.7	1.8	1.9	1.2	0.8	1.5
Impedance of arm (left)	1.0	4.6	11.5	3.4	2.7	-1.0	1.5	1.0
Exposure to tobacco smoke at home	1.0	1.1	2.1	-1.4	-1.3	0.9	0.7	0.5
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	4.5	0.4	-0.0	1.5	1.8	2.1
Angina (self-reported)	1.0	1.3	2.5	-1.6	-1.4	0.8	0.9	0.7
Leg pain on walking	1.0	1.3	3.4	-0.4	-0.4	1.2	1.1	1.9
Supplements: Vitamin C	1.0	1.2	3.5	-0.6	-0.5	0.6	1.9	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.0	-1.4	-1.4	1.0	1.0	0.1
Smoking status: Previous	1.0	1.6	2.4	-1.0	-1.0	-1.4	-1.2	-1.6
Medication: Paracetamol	1.0	1.6	5.0	1.2	0.8	-0.4	0.8	2.2
Medication: Metformin	0.9	1.2	3.5	-1.9	-1.6	-0.2	-0.2	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.1	0.0	-0.3	1.3	1.8	1.0
Hair/balding pattern: Pattern 2	0.9	1.1	2.4	0.7	0.5	-1.0	-1.5	-1.2
Weight	0.9	4.3	14.5	0.5	1.1	-1.7	-3.8	-1.6
Mean time to correctly identify matches	0.9	1.7	4.0	1.1	0.4	1.2	1.4	2.0
Loneliness, isolation	0.9	1.3	2.5	1.6	1.4	0.4	-1.3	0.4
Medication: Blood pressure	0.9	1.6	3.8	-1.8	-1.9	0.6	-0.2	-0.8
Medication: Lisinopril	0.9	1.2	2.1	-0.8	-0.4	-1.0	-1.4	-1.4
Reaction Time	0.8	1.5	3.5	1.6	1.2	0.1	0.3	1.9
Angina	0.8	1.0	2.4	-1.6	-1.3	0.5	0.7	0.5
Taking other prescription medications	0.8	1.2	2.2	-1.3	-1.3	1.5	0.1	0.7
Age when periods started (menarche)	0.8	1.8	4.6	-1.3	-1.3	-1.1	0.1	-2.1
Stomach or abdominal pain in last month	0.8	1.0	3.8	-0.8	-0.5	-0.4	2.0	0.2
Trunk fat mass	0.8	3.3	7.1	1.3	1.6	-2.0	-2.7	-1.1
Forced vital capacity (FVC)	0.8	3.0	5.9	1.8	1.8	1.4	0.7	2.4
Impedance of arm (right)	0.8	3.9	9.9	3.1	2.6	-1.2	1.0	0.8
Illnesses of mother	0.8	1.0	1.9	1.4	1.4	0.5	-1.1	0.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.1	-0.2	0.6	1.7	0.8	1.5
Gout (self-reported)	0.8	1.1	2.6	-0.3	-0.4	-1.0	-1.6	-1.2
Birth weight	0.8	1.7	4.4	0.3	0.9	-0.8	-2.1	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.2	-0.5	-0.2	1.5	0.8	1.3
Number of children fathered	0.8	1.0	1.7	-1.3	-1.0	1.0	0.0	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.9	-0.7	-1.0	1.4	0.5	1.0
Medication: Blood pressure	0.8	1.5	2.9	-1.7	-1.5	1.2	-0.3	-0.8
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.3	1.5	1.3	-0.5	0.3	0.6
Illnesses of father: Heart disease	0.8	1.1	2.7	-1.6	-1.2	0.7	0.9	-0.4
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.6	1.6	0.9	-0.4	-0.3	1.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	-0.9	-1.1	1.4	0.8	0.1
High cholesterol (Self-reported)	0.8	1.4	3.3	-0.1	0.3	-1.7	-1.8	-1.0
Medication: Atorvastatin	0.8	1.0	2.2	-1.0	-1.3	0.1	1.5	0.2
Leg fat mass (left)	0.8	3.0	8.6	0.0	0.5	-1.9	-2.9	-1.6
Alzheimer’s Disease (in mother)	0.7	0.8	2.0	0.6	1.0	-1.4	-0.1	-0.6
Chronotype (morning person)	0.7	1.5	2.9	1.7	1.5	-1.0	-1.2	-0.4
Severe depression (siblings)	0.7	0.8	1.8	-0.5	-0.6	0.5	1.3	1.3
Trunk fat percentage	0.7	2.7	4.2	1.6	1.7	-2.0	-1.9	-0.7
Current tobacco smoking	0.7	1.1	3.5	-1.2	-0.8	1.9	0.2	0.2
Average weekly fortified wine intake	0.7	0.9	3.3	-0.3	-0.3	1.8	0.3	0.9
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.3	-1.2	-1.0	-0.2	1.0	0.5
Medication: Atenolol	0.7	0.9	1.9	-1.2	-1.4	0.2	-0.7	-0.8
Waist circumference	0.7	2.5	9.5	-0.8	-0.4	-0.6	-3.1	-1.4
Mouth/teeth dental problems	0.7	1.0	2.2	1.5	1.3	-0.8	-0.7	-0.4
Noisy workplace	0.7	0.8	1.7	-0.8	-1.3	1.1	0.2	0.8
Prospective memory result	0.7	0.9	1.3	1.1	1.0	-1.1	-0.9	-0.4
Medication: Paracetamol	0.7	1.1	2.3	1.2	0.9	-1.0	-0.3	1.5
Arm fat-free mass (right)	0.7	3.4	10.9	-1.5	-0.7	-0.4	-3.3	-1.7
Whole body fat mass	0.7	3.1	7.1	1.0	1.3	-2.0	-2.7	-1.2
Leg fat mass (right)	0.7	2.8	7.8	0.1	0.5	-1.9	-2.8	-1.5
Arm predicted mass (right)	0.7	3.4	12.1	-1.3	-0.4	-0.3	-3.5	-1.7
Medication: Aspirin	0.7	0.9	3.0	-0.8	-0.7	0.1	-1.7	-0.7
Illnesses of siblings: Diabetes	0.7	0.9	2.4	0.8	0.7	0.7	-0.7	1.6
Osteoarthritis (self-reported)	0.7	0.9	2.4	0.8	0.8	0.6	0.8	1.5
Smoking status: Current	0.7	1.1	3.8	-1.0	-0.5	1.9	0.3	0.6
Hearing aid user	0.7	0.7	1.6	1.2	1.3	-0.3	-0.7	0.2
Leg fat percentage (left)	0.7	2.4	5.7	0.4	0.6	-2.4	-1.9	-1.4
Risk taking	0.7	1.0	2.3	0.6	1.5	-0.8	-0.7	-1.2
Commuting to job workplace: Cycle	0.7	0.8	1.2	0.8	0.8	1.1	0.7	1.0
Arm predicted mass (left)	0.7	3.4	12.5	-1.4	-0.4	-0.3	-3.5	-1.5
Crohns Disease (2017)	0.6	1.4	4.3	-0.9	-0.8	2.1	1.1	-0.1
Ulcerative Colitis (UC)	0.6	1.1	2.3	1.2	0.6	-1.1	-1.5	-0.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.2	-0.3	0.0	0.0	-0.5	-1.8
Pack years adult smoking proportion	0.6	1.0	2.8	-0.6	-0.6	0.2	-1.1	-1.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.8	1.1	1.4	-0.7	-0.4	0.2
Past tobacco smoking	0.6	1.2	2.0	0.6	0.4	1.2	1.4	1.4
Hip circumference	0.6	2.7	5.8	1.2	1.7	-1.7	-2.4	-0.7
Arm fat mass (right)	0.6	2.5	8.0	0.3	0.6	-1.7	-2.8	-1.2
Standing height	0.6	5.6	14.7	1.8	2.6	-1.2	-3.8	-1.4
Body fat percentage	0.6	2.3	4.7	1.0	1.2	-2.2	-1.8	-1.1
Leg fat percentage (right)	0.6	2.1	5.3	0.3	0.5	-2.3	-1.8	-1.3
Commuting to job workplace: Public transport	0.6	0.7	1.4	-0.2	-0.0	-1.1	-0.9	-1.2
Basal metabolic rate	0.6	3.1	13.6	-0.2	0.5	-0.6	-3.7	-1.1
Arm fat-free mass (left)	0.6	3.0	11.0	-1.3	-0.4	-0.1	-3.3	-1.4
Alzheimer’s Disease (including proxy)	0.5	0.8	1.8	0.8	1.3	-1.1	-0.0	-0.5
Crohns Disease (2012)	0.5	0.9	3.0	-0.8	0.0	1.7	0.8	0.2
Ulcerative Colitis	0.5	0.7	3.2	-0.2	0.0	-0.5	-1.8	0.0
Relative age of first facial hair	0.5	1.0	2.3	0.3	0.4	1.5	0.8	1.4
Leg fat-free mass (left)	0.5	2.8	11.6	0.6	1.2	-0.5	-3.4	-0.4
Sitting height	0.5	3.7	11.8	1.4	1.8	-0.7	-3.4	-0.9
Leg predicted mass (left)	0.5	2.7	11.2	0.6	1.2	-0.5	-3.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.3	-1.5	-1.4	0.3	1.0	-0.7
Arm fat percentage (right)	0.5	1.8	4.1	0.9	1.0	-1.7	-2.0	-0.6
Trunk fat-free mass	0.5	2.9	11.9	-1.0	-0.2	0.1	-3.4	-1.2
Time employed in main current job	0.5	0.5	2.0	-0.4	-0.7	-0.3	-0.1	-1.4
Father’s age at death	0.5	0.6	2.8	-0.4	-0.1	1.7	0.2	0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.5	1.1	1.2	1.4	0.6	1.9
Trunk predicted mass	0.5	3.0	12.1	-1.1	-0.3	0.1	-3.5	-1.3
Loud music exposure frequency	0.5	0.5	1.1	0.2	0.6	-1.1	-0.5	0.9
Shortness of breath walking on level ground	0.5	0.6	2.2	-0.7	-0.4	-0.1	-1.5	-0.3
Pulse rate, automated reading	0.5	1.7	4.1	-2.0	-1.7	0.5	-0.5	-1.1
Had major operations	0.5	0.6	1.1	0.7	1.1	0.5	-0.5	1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.2	1.1	1.0	-0.6	-0.4	-0.1
Knee pain experienced in last month	0.5	0.7	1.9	0.5	0.4	-0.1	1.2	1.4
Whole body fat-free mass	0.5	2.6	11.6	-0.7	0.1	-0.1	-3.4	-1.1
Leg fat-free mass (right)	0.5	2.8	11.7	0.6	1.2	-0.5	-3.4	-0.5
Ever had bowel cancer screening	0.5	0.5	1.5	-0.5	0.3	-1.2	-0.6	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	0.9	1.0	0.5	0.7	1.2
Asthma (self-reported)	0.5	0.9	3.7	-0.0	-0.2	-1.9	-0.7	-0.7
Whole body water mass	0.5	2.7	11.4	-0.8	-0.0	-0.1	-3.4	-1.1
Leg predicted mass (right)	0.5	2.5	10.6	0.5	1.2	-0.4	-3.3	-0.4
Arm fat mass (left)	0.5	2.1	6.4	0.5	0.8	-1.6	-2.5	-1.0
Ever smoked	0.5	0.8	1.9	-0.4	-0.1	-0.5	-1.4	-1.3
Pack years of smoking	0.5	0.7	2.2	-0.2	-0.2	-0.0	-1.1	-1.5
Impedance of whole body	0.5	2.8	5.9	2.4	2.0	-1.5	1.2	0.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.6	-1.3	-0.7	1.3	-0.8	-0.3
Neuroticism (2016)	0.4	0.5	1.4	0.2	-0.3	1.2	0.8	0.7
Blood Red Count	0.4	4.1	11.2	-1.1	-1.1	3.3	1.6	2.2
Ever used hormone-replacement therapy (HRT)	0.4	0.4	0.8	-0.3	-0.8	0.4	0.9	0.7
Vitamin and mineral supplements	0.4	0.5	1.2	-0.1	0.2	-1.1	-0.8	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.0	-1.4	-1.3	0.7	0.9	-0.5
Worrier / anxious feelings	0.4	0.7	1.6	-0.8	-1.3	-0.6	0.7	-0.6
Falls in the last year	0.4	0.6	1.3	0.7	0.6	-1.2	-0.5	-0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	0.9	1.1	0.3	-0.4	0.8
Asthma	0.4	0.8	3.7	-0.2	-0.3	-1.9	-0.3	-0.4
Medication: Cholesterol lowering	0.4	0.6	1.8	0.6	0.9	-0.6	-1.3	0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.4	0.3	-0.1	1.2	0.4	1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.6	0.5	0.2	-0.4	1.6	0.8
Pulse wave peak to peak time	0.4	0.5	1.1	1.0	1.1	-0.1	-0.4	0.2
Migraine (self-reported)	0.4	0.5	0.8	-0.4	-0.7	0.9	0.4	0.8
Alcohol intake frequency.	0.4	1.0	3.2	0.1	0.0	1.8	0.2	1.3
Arm fat percentage (left)	0.4	1.4	2.6	1.0	1.0	-1.6	-1.6	-0.4
Commuting to job workplace: Walk	0.4	0.4	1.5	-1.2	-0.5	0.7	-0.0	-0.2
Back pain experienced in last month	0.4	0.5	1.3	-0.8	-0.7	0.3	1.1	0.3
Medication: Aspirin	0.4	0.6	1.2	-0.8	-0.7	0.5	-1.1	-0.4
Average weekly champagne plus white wine intake	0.4	0.6	1.3	0.5	0.8	-1.2	-0.7	-0.3
Ever depressed for a whole week	0.4	0.5	1.4	-0.1	-0.2	0.6	-0.8	1.2
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.6	-1.3	-0.8	0.7	-0.9	-1.1
Schizophrenia (2018)	0.3	0.6	1.9	0.9	1.4	0.2	-0.2	0.0
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	1.1	0.0	0.9	0.1	0.0
Alzheimer’s Disease (in father)	0.3	0.3	1.0	-0.2	0.3	1.0	0.5	-0.3
Mean Putamen Volume	0.3	0.3	0.9	0.5	0.2	-0.2	0.9	0.5
Blood Eosinophil Count	0.3	2.3	5.3	-0.7	-1.2	-2.0	2.3	0.7
Blood White Count	0.3	2.5	6.8	-1.6	-1.4	-2.6	1.0	-0.4
Heel T-Score	0.3	2.3	4.3	-2.1	-1.9	0.6	1.7	-0.6
Lung FEV1/FVC ratio	0.3	1.6	3.0	-1.7	-1.6	0.6	0.6	-1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	-0.8	-0.3	1.0	-0.0	0.2
Medication: Co-codamol	0.3	0.3	1.1	-0.0	-0.0	1.0	0.4	0.5
Body mass index (BMI)	0.3	1.3	4.5	-0.4	-0.2	-1.1	-2.1	-1.0
Impedance of leg (left)	0.3	1.2	3.6	0.7	0.7	-1.9	0.7	-1.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	-0.6	-0.6	1.1	0.0	0.6
Heart attack	0.3	0.4	0.9	-0.7	-1.0	0.5	-0.3	-0.4
Medication: Simvastatin	0.3	0.5	1.3	0.4	0.6	-0.7	-1.1	0.2
Illnesses of siblings	0.3	0.4	0.9	0.5	0.5	-0.7	-0.6	-0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	1.8	-1.3	-0.9	0.2	0.0	0.2
Birth weight of first child	0.3	0.5	1.2	-1.1	-0.7	-0.4	-0.1	-0.9
Pulse wave reflection index	0.3	0.3	0.6	0.7	0.7	-0.4	-0.4	0.5
Comparative body size at age 10	0.3	0.9	1.9	0.8	1.0	-0.4	-1.4	-1.0
Number of full brothers	0.3	0.4	0.7	-0.8	-0.7	0.7	0.7	0.1
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.6	-0.2	-0.4	1.3	0.2	-0.1
Family relationship satisfaction	0.3	0.4	1.5	-0.3	-0.4	0.1	1.2	0.5
Osteoporosis (self-reported)	0.3	0.4	0.9	0.9	0.9	-0.7	-0.1	0.2
Illnesses of father: None of the above (group 1)	0.3	0.4	0.6	0.7	0.6	-0.8	-0.5	0.1
Number of self-reported non-cancer illnesses	0.3	0.6	1.7	-0.6	-0.5	0.8	0.1	1.3
Ever taken oral contraceptive pill	0.3	0.3	1.1	-0.5	-0.5	1.0	-0.1	-0.0
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	0.9	0.7	-0.7	-0.0	0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.3	0.2	0.1	0.3	1.1	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	-0.9	-0.5	0.0	0.7	0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-0.7	-1.0	0.5	-0.5	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	0.6	1.3	-0.1	-0.6	0.0
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	-0.4	-0.6	1.1	-0.1	-0.4
Ovarian Cancer	0.2	0.3	0.6	-0.1	-0.4	0.7	0.5	0.8
Lupus	0.2	0.3	0.9	0.5	0.3	-0.5	0.9	-0.3
BMI	0.2	1.0	2.1	-0.4	-0.2	-1.1	-1.4	-1.1
Height	0.2	4.2	8.1	1.7	2.5	-0.8	-2.8	-1.7
Hypothyroidism (self reported)	0.2	0.5	1.6	0.5	0.1	0.7	0.6	1.3
Hair Pigment	0.2	6.7	14.5	3.7	3.8	-1.7	-1.4	0.6
Medication for hormone replacement therapy	0.2	0.3	0.7	-0.4	-0.8	0.5	0.4	0.0
Impedance of leg (right)	0.2	1.0	3.2	0.5	0.4	-1.8	0.8	-1.0
Allergy	0.2	0.6	1.0	0.7	1.0	1.0	-0.0	-0.6
Pain all over the body in last month	0.2	0.2	0.4	-0.1	-0.5	0.7	0.7	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.2	0.4	0.1	0.0	0.3	1.1
Fluid intelligence score	0.2	0.5	0.9	-1.0	-0.7	0.9	0.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.7	0.1	0.1	0.7	0.6
Medication: Lansoprazole	0.2	0.3	0.9	-0.9	-0.6	0.3	-0.0	0.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.7	-0.7	0.2	0.1	-0.0
Length of working week for main job	0.2	0.2	0.7	-0.3	-0.1	-0.8	0.1	-0.4
Peak expiratory flow (PEF)	0.2	0.5	1.1	0.8	1.0	-0.3	-0.6	0.6
Headache pain in last month	0.2	0.4	0.9	0.5	0.1	1.0	0.4	0.8
Medication: Amlodipine	0.2	0.3	1.5	-0.2	-0.2	1.2	-0.0	0.2
Health satisfaction	0.2	0.2	0.8	-0.4	-0.1	-0.2	-0.9	0.2
Qualifications: College or University degree	0.2	0.7	1.6	0.9	1.3	-0.5	0.7	0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.4	0.4	0.3	0.2	-0.9
Medication: Ibuprofen	0.2	0.3	0.8	0.9	0.4	-0.3	0.6	0.3
Medication: Allopurinol	0.2	0.2	0.4	-0.2	-0.6	0.2	-0.7	-0.6
Heart disease (mother)	0.2	0.3	0.6	-0.7	-0.7	-0.0	0.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.1	0.1	0.9	0.4	0.2
Friendships satisfaction	0.2	0.3	0.7	-0.8	-0.7	-0.3	0.5	0.1
Guilty feelings	0.2	0.3	0.7	-0.5	-0.5	-0.1	0.9	0.6
Mother’s age at death	0.2	0.3	0.8	-0.1	0.2	-0.5	-0.9	-0.5
Illnesses of father: High blood pressure	0.2	0.3	1.0	-0.4	-0.5	-0.0	0.4	1.0
Cholesterol lowering medication	0.2	0.3	0.7	-0.5	-0.4	-0.8	-0.5	0.3
Major Depression (MDD)	0.1	0.1	0.4	0.3	0.6	-0.4	0.0	0.0
Coronary Artery Disease (CAD)	0.1	0.1	0.7	-0.9	0.0	0.0	0.0	0.0
Smoking Status	0.1	0.3	0.6	-0.7	-0.3	-0.3	-0.7	-0.7
Respiratory disease	0.1	0.3	1.4	0.1	0.0	-1.2	0.3	-0.2
Tanning	0.1	1.8	3.8	0.3	0.4	-1.9	-1.8	-1.3
Relative age voice broke	0.1	0.1	0.2	-0.3	-0.1	-0.0	-0.5	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.5	-0.6	0.3	0.1	0.6
Pulse rate	0.1	0.2	0.4	-0.1	0.1	-0.5	-0.6	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.2	0.3	-0.0	0.7	0.0
Hair/balding pattern: Pattern 4	0.1	0.3	1.3	-0.5	-1.1	0.2	0.2	-0.3
Glaucoma (self-reported)	0.1	0.1	0.1	0.2	-0.3	-0.0	0.3	0.4
Mineral and other dietary supplements	0.1	0.2	0.5	-0.2	0.1	-0.6	-0.7	-0.1
Alcohol drinker status: Never	0.1	0.1	0.3	0.3	0.5	0.1	0.2	0.1
Bipolar Disorder (2018)	0.0	0.1	0.3	-0.1	0.0	-0.2	-0.6	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.0	0.3	0.1	0.0	-0.1
Multivitamins +/- minerals	0.0	0.1	0.1	0.3	0.1	0.3	-0.1	-0.2
Depression (self-reported)	0.0	0.0	0.1	-0.1	0.2	0.0	-0.2	-0.2

Hub : Genes

COPS7A

Models

Trait associations