Hub : Genes

COPS7A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1756	0.0504	1.9e-05	0.067	NA	0.081	NA	0.097	5.9e-06	NA	6.0e-07	NA	4.7e-08
2	GTEx	Nerve Tibial	0.1675	0.0557	2.6e-03	0.131	NA	0.088	NA	0.120	1.6e-09	NA	8.2e-07	NA	7.9e-09
3	YFS	Blood	0.1262	0.0290	9.5e-14	0.043	0.044	0.052	0.043	0.043	6.1e-14	3.3e-14	1.8e-16	5.1e-14	5.0e-14
4	TCGA	Brain Lower Grade Glioma	0.0594	0.0292	2.4e-03	-0.002	0.009	0.010	NA	0.002	9.1e-01	2.6e-02	2.1e-02	NA	1.7e-01
5	TCGA	Stomach Adenocarcinoma	0.1190	0.0640	5.6e-03	0.003	0.002	0.008	NA	0.005	1.9e-01	2.1e-01	8.3e-02	NA	1.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.0	0.1	0.3	-0.1	0.0	-0.2	-0.6	0.0
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	0.6	1.3	-0.1	-0.6	0.0
Depressed Affect (Nagel 2018)	2.9	6.1	10.5	1.6	1.1	2.8	2.9	3.2
Depression (Nagel 2018)	1.6	2.4	4.5	0.9	0.7	1.6	2.1	1.8
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.6	-1.3	-0.8	0.7	-0.9	-1.1
Neuroticism (Nagel 2018)	2.7	6.5	15.3	-0.3	-0.9	2.9	3.9	2.7
Schizophrenia (2018)	0.3	0.6	1.9	0.9	1.4	0.2	-0.2	0.0
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	1.1	0.0	0.9	0.1	0.0
Worry (Nagel 2018)	3.2	6.7	13.9	-2.0	-2.7	2.4	3.7	1.6
Alzheimer’s Disease (in mother)	0.7	0.8	2.0	0.6	1.0	-1.4	-0.1	-0.6
Alzheimer’s Disease (in father)	0.3	0.3	1.0	-0.2	0.3	1.0	0.5	-0.3
Alzheimer’s Disease (including proxy)	0.5	0.8	1.8	0.8	1.3	-1.1	-0.0	-0.5
Crohns Disease (2017)	0.6	1.4	4.3	-0.9	-0.8	2.1	1.1	-0.1
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	-0.4	-0.6	1.1	-0.1	-0.4
Ulcerative Colitis (UC)	0.6	1.1	2.3	1.2	0.6	-1.1	-1.5	-0.3
Major Depression (MDD)	0.1	0.1	0.4	0.3	0.6	-0.4	0.0	0.0
Reaction Time	0.8	1.5	3.5	1.6	1.2	0.1	0.3	1.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.6	-1.3	-0.7	1.3	-0.8	-0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.2	0.3	0.6	-0.1	-0.4	0.7	0.5	0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.7	2.4	7.1	2.7	1.8	-0.3	0.7	1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.1	1.5	4.6	-1.0	-0.9	1.2	2.1	-0.0
Coronary Artery Disease (CAD)	0.1	0.1	0.7	-0.9	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.5	0.9	3.0	-0.8	0.0	1.7	0.8	0.2
Mean Putamen Volume	0.3	0.3	0.9	0.5	0.2	-0.2	0.9	0.5
Fasting Glucose	2.7	3.2	7.1	-2.0	-1.6	-0.7	-1.4	-2.7
HbA1C	1.7	1.9	5.9	-1.2	-0.5	-0.9	-1.1	-2.4
HDL Cholesterol	1.1	1.8	3.5	1.8	1.9	-1.2	-1.0	-0.2
LDL Cholesterol	1.1	1.7	4.9	0.2	0.2	-2.2	0.1	-1.9
Lupus	0.2	0.3	0.9	0.5	0.3	-0.5	0.9	-0.3
Neuroticism (2016)	0.4	0.5	1.4	0.2	-0.3	1.2	0.8	0.7
Primary Biliary Cirrhosis	1.4	2.0	3.3	1.4	1.6	-1.4	-1.8	-0.1
Rheumatoid Arthritis	1.0	1.4	1.8	1.3	1.0	1.3	0.7	1.4
Schizophrenia (2014)	1.1	2.5	5.4	1.4	1.8	1.0	1.0	2.3
Triglycerides	1.8	2.9	6.3	-2.3	-2.5	1.0	1.4	-0.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.2	-0.3	0.0	0.0	-0.5	-1.8
Ulcerative Colitis	0.5	0.7	3.2	-0.2	0.0	-0.5	-1.8	0.0
Blood Eosinophil Count	0.3	2.3	5.3	-0.7	-1.2	-2.0	2.3	0.7
Blood Platelet Count	1.0	11.2	21.5	-4.6	-4.5	-1.1	3.5	0.4
Blood Red Count	0.4	4.1	11.2	-1.1	-1.1	3.3	1.6	2.2
Blood White Count	0.3	2.5	6.8	-1.6	-1.4	-2.6	1.0	-0.4
Heel T-Score	0.3	2.3	4.3	-2.1	-1.9	0.6	1.7	-0.6
BMI	0.2	1.0	2.1	-0.4	-0.2	-1.1	-1.4	-1.1
Height	0.2	4.2	8.1	1.7	2.5	-0.8	-2.8	-1.7
Waist Hip Ratio (WHR)	1.0	4.3	9.1	-2.7	-3.0	1.7	-1.3	-0.8
Systolic Blood Pressure	1.9	9.4	19.2	-4.4	-4.3	2.2	1.7	-1.1
Smoking Status	0.1	0.3	0.6	-0.7	-0.3	-0.3	-0.7	-0.7
Allergy or Eczema	2.0	5.2	6.6	-1.8	-2.4	2.0	2.5	2.6
Cardiovascular Disease	2.1	6.8	15.0	-3.9	-3.3	0.5	-1.4	-2.5
Hypothyroidism (self reported)	0.2	0.5	1.6	0.5	0.1	0.7	0.6	1.3
Respiratory disease	0.1	0.3	1.4	0.1	0.0	-1.2	0.3	-0.2
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.0	-1.7	-1.2	-0.8	-1.6	-1.2
Lung FEV1/FVC ratio	0.3	1.6	3.0	-1.7	-1.6	0.6	0.6	-1.1
Lung FVC	1.5	7.8	16.5	0.9	0.4	4.1	2.6	3.8
Neuroticism	2.4	5.9	16.1	-0.7	-1.5	2.3	4.0	2.3
Chronotype (morning person)	0.7	1.5	2.9	1.7	1.5	-1.0	-1.2	-0.4
Hair Pigment	0.2	6.7	14.5	3.7	3.8	-1.7	-1.4	0.6
Tanning	0.1	1.8	3.8	0.3	0.4	-1.9	-1.8	-1.3
Hand grip strength (left)	1.5	3.9	9.1	1.7	2.2	-1.5	-3.0	-0.4
Number of treatments/medications taken	1.5	2.7	4.4	-2.0	-2.1	2.0	0.5	0.9
Average weekly spirits intake	1.3	1.6	3.6	-0.7	-0.3	-1.9	-0.9	-1.8
Sensitivity / hurt feelings	1.7	2.9	8.2	1.6	0.8	1.2	1.3	2.9
Frequency of depressed mood in last 2 weeks	1.9	2.6	3.9	1.4	1.1	1.5	2.0	2.0
Hearing difficulty/problems: Yes	3.6	5.6	10.6	-0.4	-0.8	3.3	2.6	3.1
Relative age of first facial hair	0.5	1.0	2.3	0.3	0.4	1.5	0.8	1.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	-0.8	-0.3	1.0	-0.0	0.2
Ever used hormone-replacement therapy (HRT)	0.4	0.4	0.8	-0.3	-0.8	0.4	0.9	0.7
Ever had hysterectomy (womb removed)	1.5	1.7	2.3	-1.5	-1.0	-0.9	-1.5	-1.4
Systolic blood pressure, automated reading	2.3	6.6	14.1	-3.6	-3.8	1.4	1.1	-1.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.5	-0.3	0.1	-1.2	-1.2	-1.6
Angina	0.8	1.0	2.4	-1.6	-1.3	0.5	0.7	0.5
Medication for hormone replacement therapy	0.2	0.3	0.7	-0.4	-0.8	0.5	0.4	0.0
Vitamin and mineral supplements	0.4	0.5	1.2	-0.1	0.2	-1.1	-0.8	-0.8
Supplements: Zinc	3.6	3.9	9.9	-1.5	-1.4	1.9	3.1	1.3
Medication: Co-codamol	0.3	0.3	1.1	-0.0	-0.0	1.0	0.4	0.5
Medication: Metformin	0.9	1.2	3.5	-1.9	-1.6	-0.2	-0.2	-0.3
Diabetes (father)	1.5	1.9	3.4	1.0	1.6	-1.4	-1.8	-0.8
Diabetes (mother)	1.8	2.3	3.8	-1.9	-1.5	-0.4	-1.3	-1.9
Severe depression (siblings)	0.7	0.8	1.8	-0.5	-0.6	0.5	1.3	1.3
Pack years adult smoking proportion	0.6	1.0	2.8	-0.6	-0.6	0.2	-1.1	-1.7
Impedance of leg (right)	0.2	1.0	3.2	0.5	0.4	-1.8	0.8	-1.0
Leg fat-free mass (left)	0.5	2.8	11.6	0.6	1.2	-0.5	-3.4	-0.4
Trunk fat percentage	0.7	2.7	4.2	1.6	1.7	-2.0	-1.9	-0.7
Hand grip strength (right)	1.6	4.4	9.6	1.9	2.5	-1.7	-3.1	-0.3
Townsend deprivation index at recruitment	1.0	1.4	3.0	-1.7	-1.7	0.9	0.1	-0.3
Current tobacco smoking	0.7	1.1	3.5	-1.2	-0.8	1.9	0.2	0.2
Average weekly fortified wine intake	0.7	0.9	3.3	-0.3	-0.3	1.8	0.3	0.9
Maternal smoking around birth	1.1	1.6	3.8	-1.9	-1.9	-0.5	-0.0	-0.7
Fed-up feelings	2.0	3.7	7.6	0.5	-0.1	2.1	2.8	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.1	0.0	-0.3	1.3	1.8	1.0
Relative age voice broke	0.1	0.1	0.2	-0.3	-0.1	-0.0	-0.5	-0.5
Taking other prescription medications	0.8	1.2	2.2	-1.3	-1.3	1.5	0.1	0.7
Age when periods started (menarche)	0.8	1.8	4.6	-1.3	-1.3	-1.1	0.1	-2.1
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	4.9	-1.5	-0.7	-1.1	-1.9	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.0	-1.4	-1.3	0.7	0.9	-0.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.3	-1.2	-1.0	-0.2	1.0	0.5
Qualifications: CSEs or equivalent	1.5	2.0	4.3	0.2	-0.4	1.4	1.9	2.1
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.0	0.3	0.1	0.0	-0.1
High blood pressure	1.8	5.2	12.1	-3.5	-3.1	1.0	-0.0	-1.7
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.4	-1.7	-2.1	0.6	1.2	1.4
Multivitamins +/- minerals	0.0	0.1	0.1	0.3	0.1	0.3	-0.1	-0.2
Stomach or abdominal pain in last month	0.8	1.0	3.8	-0.8	-0.5	-0.4	2.0	0.2
Supplements: Glucosamine	2.3	3.0	6.9	2.3	2.6	-1.5	-0.7	-0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.8	1.1	1.4	-0.7	-0.4	0.2
Medication: Atenolol	0.7	0.9	1.9	-1.2	-1.4	0.2	-0.7	-0.8
Medication: Levothyroxine sodium	1.4	2.4	5.8	0.6	0.1	1.8	1.7	2.4
Sitting height	0.5	3.7	11.8	1.4	1.8	-0.7	-3.4	-0.9
Chronic bronchitis/emphysema (father)	1.6	1.9	5.2	-0.9	-0.5	-0.9	-1.6	-2.3
High blood pressure (mother)	1.8	2.5	4.0	-2.0	-1.8	1.4	1.1	1.4
Body mass index (BMI)	0.3	1.3	4.5	-0.4	-0.2	-1.1	-2.1	-1.0
Impedance of leg (left)	0.3	1.2	3.6	0.7	0.7	-1.9	0.7	-1.1
Leg predicted mass (left)	0.5	2.7	11.2	0.6	1.2	-0.5	-3.3	-0.4
Trunk fat mass	0.8	3.3	7.1	1.3	1.6	-2.0	-2.7	-1.1
Waist circumference	0.7	2.5	9.5	-0.8	-0.4	-0.6	-3.1	-1.4
Number of incorrect matches in round	1.4	2.3	5.1	-0.1	-0.8	2.2	2.3	1.0
Past tobacco smoking	0.6	1.2	2.0	0.6	0.4	1.2	1.4	1.4
Alcohol usually taken with meals	1.3	2.1	4.0	1.8	2.0	-0.5	-1.7	0.3
Nervous feelings	3.5	6.5	15.1	-2.3	-2.6	2.0	3.9	1.2
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	5.6	-0.6	-1.3	2.3	2.4	1.7
Hearing difficulty/problems with background noise	8.8	14.1	23.3	-3.1	-3.6	4.8	3.8	3.1
Hair/balding pattern: Pattern 2	0.9	1.1	2.4	0.7	0.5	-1.0	-1.5	-1.2
Had menopause	2.0	2.6	5.4	-1.8	-2.3	1.1	1.7	-0.2
Had other major operations	2.0	2.5	5.4	-1.2	-1.1	1.0	2.3	1.7
Forced vital capacity (FVC)	0.8	3.0	5.9	1.8	1.8	1.4	0.7	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.3	-1.5	-1.4	0.3	1.0	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	-0.6	-0.6	1.1	0.0	0.6
Qualifications: None of the above	1.3	2.8	4.9	-0.9	-1.2	-1.4	-2.2	-2.2
Financial difficulties in last 2 years	3.4	4.6	10.3	-2.8	-3.2	0.6	-1.3	-1.8
Mouth/teeth dental problems	0.7	1.0	2.2	1.5	1.3	-0.8	-0.7	-0.4
Heart attack	0.3	0.4	0.9	-0.7	-1.0	0.5	-0.3	-0.4
Allergy	0.2	0.6	1.0	0.7	1.0	1.0	-0.0	-0.6
Pain all over the body in last month	0.2	0.2	0.4	-0.1	-0.5	0.7	0.7	0.2
Diabetes (self-reported)	1.7	2.7	5.5	-2.3	-2.0	-0.2	-1.4	-1.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.2	0.4	0.1	0.0	0.3	1.1
Medication: Ramipril	3.7	4.8	10.1	-3.2	-3.2	1.6	1.0	-0.7
Medication: Simvastatin	0.3	0.5	1.3	0.4	0.6	-0.7	-1.1	0.2
Fluid intelligence score	0.2	0.5	0.9	-1.0	-0.7	0.9	0.4	-0.1
Illnesses of siblings	0.3	0.4	0.9	0.5	0.5	-0.7	-0.6	-0.9
Neuroticism score	1.7	3.6	8.5	-0.3	-0.9	2.2	2.9	1.9
Weight	0.9	4.3	14.5	0.5	1.1	-1.7	-3.8	-1.6
Impedance of arm (right)	0.8	3.9	9.9	3.1	2.6	-1.2	1.0	0.8
Arm fat percentage (right)	0.5	1.8	4.1	0.9	1.0	-1.7	-2.0	-0.6
Trunk fat-free mass	0.5	2.9	11.9	-1.0	-0.2	0.1	-3.4	-1.2
Hip circumference	0.6	2.7	5.8	1.2	1.7	-1.7	-2.4	-0.7
Time employed in main current job	0.5	0.5	2.0	-0.4	-0.7	-0.3	-0.1	-1.4
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.5	-0.6	0.3	0.1	0.6
Father’s age at death	0.5	0.6	2.8	-0.4	-0.1	1.7	0.2	0.5
Worrier / anxious feelings	0.4	0.7	1.6	-0.8	-1.3	-0.6	0.7	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.6	-0.7	-0.8	1.6	1.6	1.5
Falls in the last year	0.4	0.6	1.3	0.7	0.6	-1.2	-0.5	-0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	0.9	1.1	0.3	-0.4	0.8
Number of live births	1.8	2.5	5.1	-2.3	-1.8	-0.0	-1.0	-1.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.5	1.1	1.2	1.4	0.6	1.9
Pulse rate	0.1	0.2	0.4	-0.1	0.1	-0.5	-0.6	-0.5
Happiness	1.7	2.0	4.9	-0.2	-0.2	1.7	1.5	2.2
Noisy workplace	0.7	0.8	1.7	-0.8	-1.3	1.1	0.2	0.8
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.7	1.8	1.9	1.2	0.8	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.2	0.3	-0.0	0.7	0.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.8	-1.3	-0.9	0.2	0.0	0.2
Asthma	0.4	0.8	3.7	-0.2	-0.3	-1.9	-0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.7	0.1	0.1	0.7	0.6
Medication: Cholesterol lowering	0.4	0.6	1.8	0.6	0.9	-0.6	-1.3	0.1
Depression (self-reported)	0.0	0.0	0.1	-0.1	0.2	0.0	-0.2	-0.2
Medication: Lansoprazole	0.2	0.3	0.9	-0.9	-0.6	0.3	-0.0	0.0
Prospective memory result	0.7	0.9	1.3	1.1	1.0	-1.1	-0.9	-0.4
Lung cancer (father)	1.1	1.3	3.8	0.2	0.4	-1.1	-1.9	-1.2
Illnesses of mother	0.8	1.0	1.9	1.4	1.4	0.5	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	7.0	2.5	2.7	1.2	0.2	2.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.7	-0.7	0.2	0.1	-0.0
Impedance of arm (left)	1.0	4.6	11.5	3.4	2.7	-1.0	1.5	1.0
Arm fat mass (right)	0.6	2.5	8.0	0.3	0.6	-1.7	-2.8	-1.2
Trunk predicted mass	0.5	3.0	12.1	-1.1	-0.3	0.1	-3.5	-1.3
Standing height	0.6	5.6	14.7	1.8	2.6	-1.2	-3.8	-1.4
Length of working week for main job	0.2	0.2	0.7	-0.3	-0.1	-0.8	0.1	-0.4
Exposure to tobacco smoke at home	1.0	1.1	2.1	-1.4	-1.3	0.9	0.7	0.5
Breastfed as a baby	1.8	2.2	6.9	1.2	1.2	2.6	0.1	1.1
Tense / ‘highly strung’	1.7	2.9	6.4	-2.3	-2.5	1.0	1.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.0	-0.2	-0.2	2.2	0.8	1.6
Hair/balding pattern: Pattern 4	0.1	0.3	1.3	-0.5	-1.1	0.2	0.2	-0.3
Birth weight of first child	0.3	0.5	1.2	-1.1	-0.7	-0.4	-0.1	-0.9
Peak expiratory flow (PEF)	0.2	0.5	1.1	0.8	1.0	-0.3	-0.6	0.6
Pulse wave reflection index	0.3	0.3	0.6	0.7	0.7	-0.4	-0.4	0.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.4	0.3	-0.1	1.2	0.4	1.0
Loud music exposure frequency	0.5	0.5	1.1	0.2	0.6	-1.1	-0.5	0.9
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.1	-0.2	0.6	1.7	0.8	1.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.4	-2.1	-1.8	0.4	-0.0	-1.2
Blood clot in the leg (DVT)	2.5	3.2	5.1	1.9	2.3	-2.0	-1.9	-0.0
Medication: Paracetamol	0.7	1.1	2.3	1.2	0.9	-1.0	-0.3	1.5
Headache pain in last month	0.2	0.4	0.9	0.5	0.1	1.0	0.4	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.6	0.5	0.2	-0.4	1.6	0.8
Glaucoma (self-reported)	0.1	0.1	0.1	0.2	-0.3	-0.0	0.3	0.4
Gout (self-reported)	0.8	1.1	2.6	-0.3	-0.4	-1.0	-1.6	-1.2
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	4.5	0.4	-0.0	1.5	1.8	2.1
Medication: Amlodipine	0.2	0.3	1.5	-0.2	-0.2	1.2	-0.0	0.2
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.8	1.3	1.4	-2.2	-1.8	-0.6
Birth weight	0.8	1.7	4.4	0.3	0.9	-0.8	-2.1	-1.6
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.5	-0.1	0.2	-1.9	-2.1	-1.7
High blood pressure (siblings)	1.7	2.5	5.7	-0.5	-0.6	1.7	2.4	1.9
Forced vital capacity (FVC), Best measure	1.7	6.1	10.9	3.2	3.3	1.0	0.0	2.9
Body fat percentage	0.6	2.3	4.7	1.0	1.2	-2.2	-1.8	-1.1
Leg fat percentage (right)	0.6	2.1	5.3	0.3	0.5	-2.3	-1.8	-1.3
Arm fat-free mass (right)	0.7	3.4	10.9	-1.5	-0.7	-0.4	-3.3	-1.7
Exposure to tobacco smoke outside home	2.9	3.8	6.5	-2.4	-2.5	2.2	1.5	0.0
Comparative body size at age 10	0.3	0.9	1.9	0.8	1.0	-0.4	-1.4	-1.0
Number of full brothers	0.3	0.4	0.7	-0.8	-0.7	0.7	0.7	0.1
Worry too long after embarrassment	1.6	2.7	6.9	-1.7	-1.7	0.9	2.6	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.2	-0.5	-0.2	1.5	0.8	1.3
Wheeze or whistling in the chest in last year	1.3	2.3	4.6	-0.8	-0.2	-1.9	-1.5	-2.1
Number of children fathered	0.8	1.0	1.7	-1.3	-1.0	1.0	0.0	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.9	-0.7	-1.0	1.4	0.5	1.0
Age at first live birth	4.3	7.6	17.1	4.1	4.1	-1.7	-1.0	0.6
Pulse wave peak to peak time	0.4	0.5	1.1	1.0	1.1	-0.1	-0.4	0.2
Health satisfaction	0.2	0.2	0.8	-0.4	-0.1	-0.2	-0.9	0.2
Shortness of breath walking on level ground	0.5	0.6	2.2	-0.7	-0.4	-0.1	-1.5	-0.3
Qualifications: College or University degree	0.2	0.7	1.6	0.9	1.3	-0.5	0.7	0.6
Eye problems/disorders: None of the above	2.3	2.6	5.4	2.3	2.3	-0.9	-1.0	0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.6	-0.2	-0.4	1.3	0.2	-0.1
Emphysema/chronic bronchitis	1.1	1.3	1.9	-1.4	-1.1	-1.2	-0.0	-1.4
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.4	0.4	0.3	0.2	-0.9
Neck or shoulder pain in last month	3.6	5.2	12.0	-0.5	-1.1	2.6	3.5	2.4
Medication: Blood pressure	0.8	1.5	2.9	-1.7	-1.5	1.2	-0.3	-0.8
Angina (self-reported)	1.0	1.3	2.5	-1.6	-1.4	0.8	0.9	0.7
Migraine (self-reported)	0.4	0.5	0.8	-0.4	-0.7	0.9	0.4	0.8
Medication: Ibuprofen	0.2	0.3	0.8	0.9	0.4	-0.3	0.6	0.3
Medication: Allopurinol	0.2	0.2	0.4	-0.2	-0.6	0.2	-0.7	-0.6
Medication: Omeprazole	3.8	4.5	9.2	-3.0	-2.7	1.7	1.7	-0.2
Medication: Seretide 50 evohaler	4.3	4.9	8.4	1.8	2.1	-2.9	-2.4	-1.7
Mean time to correctly identify matches	0.9	1.7	4.0	1.1	0.4	1.2	1.4	2.0
Heart disease (mother)	0.2	0.3	0.6	-0.7	-0.7	-0.0	0.4	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	2.8	-1.4	-1.5	-1.0	-1.3	-1.7
Whole body fat mass	0.7	3.1	7.1	1.0	1.3	-2.0	-2.7	-1.2
Leg fat mass (right)	0.7	2.8	7.8	0.1	0.5	-1.9	-2.8	-1.5
Arm predicted mass (right)	0.7	3.4	12.1	-1.3	-0.4	-0.3	-3.5	-1.7
Pulse rate, automated reading	0.5	1.7	4.1	-2.0	-1.7	0.5	-0.5	-1.1
Alcohol intake frequency.	0.4	1.0	3.2	0.1	0.0	1.8	0.2	1.3
Comparative height size at age 10	1.7	9.5	31.2	1.6	2.3	-2.0	-5.6	-2.2
Number of full sisters	2.5	3.0	6.4	-1.3	-0.9	-1.5	-2.0	-2.5
Suffer from ‘nerves’	2.8	4.5	6.5	-1.7	-2.2	2.3	2.6	1.7
Overall health rating	1.4	3.0	7.9	-2.8	-2.5	0.4	0.7	-0.2
Chest pain or discomfort	2.0	2.9	5.7	-2.2	-1.6	-1.2	-0.0	-2.4
Had major operations	0.5	0.6	1.1	0.7	1.1	0.5	-0.5	1.0
Age at last live birth	1.1	1.5	4.0	1.6	2.0	-1.0	-0.2	0.3
Family relationship satisfaction	0.3	0.4	1.5	-0.3	-0.4	0.1	1.2	0.5
Leg pain on walking	1.0	1.3	3.4	-0.4	-0.4	1.2	1.1	1.9
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.8	0.9	0.7	1.7	1.0	1.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.2	1.1	1.0	-0.6	-0.4	-0.1
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.3	1.5	1.3	-0.5	0.3	0.6
Medication: Aspirin	0.7	0.9	3.0	-0.8	-0.7	0.1	-1.7	-0.7
Supplements: Vitamin C	1.0	1.2	3.5	-0.6	-0.5	0.6	1.9	1.3
Knee pain experienced in last month	0.5	0.7	1.9	0.5	0.4	-0.1	1.2	1.4
Hypertension (Self-reported)	2.1	6.0	14.0	-3.7	-3.3	1.1	-0.2	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.0	-1.4	-1.4	1.0	1.0	0.1
Illnesses of father: Heart disease	0.8	1.1	2.7	-1.6	-1.2	0.7	0.9	-0.4
Illnesses of siblings: Diabetes	0.7	0.9	2.4	0.8	0.7	0.7	-0.7	1.6
Smoking status: Previous	1.0	1.6	2.4	-1.0	-1.0	-1.4	-1.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	3.9	1.6	2.0	-1.5	-1.7	0.1
Whole body fat-free mass	0.5	2.6	11.6	-0.7	0.1	-0.1	-3.4	-1.1
Leg fat-free mass (right)	0.5	2.8	11.7	0.6	1.2	-0.5	-3.4	-0.5
Arm fat percentage (left)	0.4	1.4	2.6	1.0	1.0	-1.6	-1.6	-0.4
Average weekly red wine intake	1.3	1.9	4.5	-0.3	0.6	-0.7	-2.1	-2.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.6	1.6	0.9	-0.4	-0.3	1.1
Mood swings	4.3	7.8	13.0	2.9	2.1	1.6	3.3	3.6
Loneliness, isolation	0.9	1.3	2.5	1.6	1.4	0.4	-1.3	0.4
Long-standing illness, disability or infirmity	1.1	1.7	3.2	-1.1	-1.3	1.0	1.8	1.1
Ever had bowel cancer screening	0.5	0.5	1.5	-0.5	0.3	-1.2	-0.6	-0.7
Diabetes diagnosed by doctor	1.7	2.8	4.9	-2.2	-1.9	-0.8	-1.6	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.1	0.1	0.9	0.4	0.2
Friendships satisfaction	0.2	0.3	0.7	-0.8	-0.7	-0.3	0.5	0.1
Qualifications: nursing, teaching	3.2	5.0	13.5	3.1	3.7	0.5	-0.6	1.1
Commuting to job workplace: Walk	0.4	0.4	1.5	-1.2	-0.5	0.7	-0.0	-0.2
Eye problems/disorders: Cataract	2.1	2.4	3.8	-1.8	-1.9	1.3	1.8	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	0.9	1.0	0.5	0.7	1.2
Medication for cholesterol	1.2	1.8	2.7	1.3	1.2	1.2	1.6	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.3	-1.4	-1.4	0.5	1.8	0.9
Back pain experienced in last month	0.4	0.5	1.3	-0.8	-0.7	0.3	1.1	0.3
Mineral and other dietary supplements	0.1	0.2	0.5	-0.2	0.1	-0.6	-0.7	-0.1
Breast cancer (self-reported)	1.4	1.7	4.4	-1.3	-1.0	-1.0	-0.5	-2.1
Asthma (self-reported)	0.5	0.9	3.7	-0.0	-0.2	-1.9	-0.7	-0.7
Osteoporosis (self-reported)	0.3	0.4	0.9	0.9	0.9	-0.7	-0.1	0.2
Osteoarthritis (self-reported)	0.7	0.9	2.4	0.8	0.8	0.6	0.8	1.5
Medication: Aspirin	0.4	0.6	1.2	-0.8	-0.7	0.5	-1.1	-0.4
Medication: Gliclazide	2.9	3.2	6.8	-2.6	-2.1	-1.5	-0.8	-1.4
Illnesses of father: None of the above (group 1)	0.3	0.4	0.6	0.7	0.6	-0.8	-0.5	0.1
Smoking status: Current	0.7	1.1	3.8	-1.0	-0.5	1.9	0.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	5.9	1.7	1.3	1.6	1.7	2.4
Whole body water mass	0.5	2.7	11.4	-0.8	-0.0	-0.1	-3.4	-1.1
Leg predicted mass (right)	0.5	2.5	10.6	0.5	1.2	-0.4	-3.3	-0.4
Arm fat mass (left)	0.5	2.1	6.4	0.5	0.8	-1.6	-2.5	-1.0
Number of self-reported non-cancer illnesses	0.3	0.6	1.7	-0.6	-0.5	0.8	0.1	1.3
Average weekly champagne plus white wine intake	0.4	0.6	1.3	0.5	0.8	-1.2	-0.7	-0.3
Miserableness	3.0	5.2	6.8	2.1	1.6	2.5	2.4	2.6
Guilty feelings	0.2	0.3	0.7	-0.5	-0.5	-0.1	0.9	0.6
Wears glasses or contact lenses	1.1	1.3	3.2	-0.1	-0.3	1.2	1.8	1.3
Ever taken oral contraceptive pill	0.3	0.3	1.1	-0.5	-0.5	1.0	-0.1	-0.0
Hearing aid user	0.7	0.7	1.6	1.2	1.3	-0.3	-0.7	0.2
Mother’s age at death	0.2	0.3	0.8	-0.1	0.2	-0.5	-0.9	-0.5
Financial situation satisfaction	2.8	3.5	5.5	-2.2	-2.4	2.2	1.1	0.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	-0.9	-1.1	1.4	0.8	0.1
Commuting to job workplace: Public transport	0.6	0.7	1.4	-0.2	-0.0	-1.1	-0.9	-1.2
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	0.9	0.7	-0.7	-0.0	0.3
Medication: Blood pressure	0.9	1.6	3.8	-1.8	-1.9	0.6	-0.2	-0.8
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.5	2.1	1.6	-0.0	0.8	1.9
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.3	0.2	0.1	0.3	1.1	0.5
High cholesterol (Self-reported)	0.8	1.4	3.3	-0.1	0.3	-1.7	-1.8	-1.0
Medication: Bendroflumethiazide	1.2	1.9	5.5	-0.7	-0.5	-0.8	-1.6	-2.3
Medication: Paracetamol	1.0	1.6	5.0	1.2	0.8	-0.4	0.8	2.2
Medication: Lisinopril	0.9	1.2	2.1	-0.8	-0.4	-1.0	-1.4	-1.4
Medication: Atorvastatin	0.8	1.0	2.2	-1.0	-1.3	0.1	1.5	0.2
Illnesses of father: High blood pressure	0.2	0.3	1.0	-0.4	-0.5	-0.0	0.4	1.0
Alcohol drinker status: Never	0.1	0.1	0.3	0.3	0.5	0.1	0.2	0.1
Ever smoked	0.5	0.8	1.9	-0.4	-0.1	-0.5	-1.4	-1.3
Basal metabolic rate	0.6	3.1	13.6	-0.2	0.5	-0.6	-3.7	-1.1
Leg fat percentage (left)	0.7	2.4	5.7	0.4	0.6	-2.4	-1.9	-1.4
Arm fat-free mass (left)	0.6	3.0	11.0	-1.3	-0.4	-0.1	-3.3	-1.4
Number of operations (self-reported)	1.4	2.1	5.7	-2.4	-2.1	0.4	0.4	-0.1
Average weekly beer plus cider intake	1.7	2.5	5.6	-2.0	-2.4	-0.4	0.6	-1.5
Irritability	1.2	2.1	4.2	0.8	0.1	2.0	1.9	1.4
Risk taking	0.7	1.0	2.3	0.6	1.5	-0.8	-0.7	-1.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	-0.9	-0.5	0.0	0.7	0.1
Fractured/broken bones in last 5 years	1.1	1.4	3.2	-1.3	-1.4	0.1	-1.8	-0.2
Age started oral contraceptive pill	1.2	1.6	4.3	-0.1	-0.2	1.2	2.1	1.4
Diastolic blood pressure, automated reading	1.6	5.1	10.8	-3.3	-3.3	1.2	1.2	-1.1
Ever depressed for a whole week	0.4	0.5	1.4	-0.1	-0.2	0.6	-0.8	1.2
Unable to work because of sickness or disability	1.1	1.4	3.8	-2.0	-1.8	-0.0	-0.1	-0.3
Commuting to job workplace: Cycle	0.7	0.8	1.2	0.8	0.8	1.1	0.7	1.0
Myopia	1.2	1.8	4.0	0.1	-0.3	1.5	1.6	2.0
Vascular/heart problems diagnosed by doctor	1.7	4.6	10.7	3.3	3.0	-0.8	0.1	1.6
Cholesterol lowering medication	0.2	0.3	0.7	-0.5	-0.4	-0.8	-0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.7	-1.9	-1.2	1.4	1.1	0.2
Pain experienced in last month	1.3	2.2	5.2	0.9	1.3	-1.1	-2.3	-1.4
Supplements: Calcium	1.1	1.2	4.6	-0.4	-0.2	0.6	2.1	1.0
Basal cell carcinoma (self-reported)	2.2	2.6	5.8	-2.4	-2.0	1.2	-0.2	-1.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-0.7	-1.0	0.5	-0.5	-0.4
Deep venous thrombosis (DVT) (self-reported)	3.4	4.3	6.6	2.0	2.4	-2.6	-2.2	-0.2
Heart disease (siblings)	1.1	1.4	2.9	0.7	1.1	-1.4	-1.7	-0.5
Alcohol drinker status: Previous	1.1	1.2	2.5	-1.6	-1.1	1.4	-0.1	-0.5
Pack years of smoking	0.5	0.7	2.2	-0.2	-0.2	-0.0	-1.1	-1.5
Impedance of whole body	0.5	2.8	5.9	2.4	2.0	-1.5	1.2	0.1
Leg fat mass (left)	0.8	3.0	8.6	0.0	0.5	-1.9	-2.9	-1.6
Arm predicted mass (left)	0.7	3.4	12.5	-1.4	-0.4	-0.3	-3.5	-1.5