Hub : Genes

COTL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.233	0.0670	2.1e-03	0.022	NA	0.027	NA	0.028	5.9e-03	NA	2.8e-03	NA	2.3e-03
2	GTEx	Artery Tibial	0.230	0.0643	1.9e-03	0.134	NA	0.094	NA	0.129	1.2e-10	NA	8.7e-08	NA	2.7e-10
3	GTEx	Muscle Skeletal	0.199	0.0538	4.3e-04	0.005	NA	0.024	NA	0.005	1.0e-01	NA	1.8e-03	NA	8.8e-02
4	METSIM	Adipose	0.129	0.0278	3.7e-07	0.129	0.063	0.128	0.122	0.125	8.6e-19	8.8e-10	1.4e-18	7.8e-18	3.3e-18
5	TCGA	Ovarian Serous Cystadenocarcinoma	0.117	0.0460	1.9e-03	-0.004	0.025	-0.002	NA	-0.002	9.4e-01	7.8e-03	4.5e-01	NA	5.2e-01
6	TCGA	Prostate Adenocarcinoma	0.210	0.0514	5.6e-08	0.031	0.109	0.081	NA	0.060	2.9e-04	1.8e-11	8.2e-09	NA	7.1e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.7	2.5	0.8	1.6	-0.3	0.0	1.0	0.4
Bipolar Disorder or Schizophrenia	0.9	2.2	6.1	1.2	2.5	-0.3	1.4	1.6	-1.1
Depressed Affect (Nagel 2018)	0.5	1.0	4.3	1.0	0.0	-0.9	-0.1	0.4	-2.1
Depression (Nagel 2018)	0.8	1.2	2.3	1.5	1.4	-0.8	0.3	1.3	-0.8
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	0.5	0.1	-0.1	-0.8	-0.4	-0.8
Neuroticism (Nagel 2018)	0.3	0.6	2.6	1.0	0.1	-0.2	0.2	-0.0	-1.6
Schizophrenia (2018)	1.0	2.1	3.6	1.0	1.9	0.0	1.8	1.4	-1.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	0.7	-0.9	-0.4	-0.1	-0.5	-1.1
Worry (Nagel 2018)	0.3	0.7	3.2	0.8	-0.2	0.7	0.1	-0.2	-1.8
Alzheimer’s Disease (in mother)	0.8	0.9	4.3	0.6	-0.2	-0.8	0.4	0.4	-2.1
Alzheimer’s Disease (in father)	1.2	1.3	6.5	0.9	-0.4	-2.5	-0.1	0.6	0.4
Alzheimer’s Disease (including proxy)	0.6	0.9	1.6	1.1	0.6	-1.1	0.8	0.5	-1.3
Crohns Disease (2017)	0.7	1.5	5.1	2.3	1.1	1.3	0.8	0.1	0.3
Irritable Bowel Disease (IBD)	1.0	2.4	7.2	2.7	1.8	1.0	1.4	0.9	-0.5
Ulcerative Colitis (UC)	1.3	2.3	4.7	2.2	1.6	0.8	1.7	1.4	-1.1
Major Depression (MDD)	2.0	2.4	6.7	-1.6	-0.6	-2.0	-0.9	-0.2	2.6
Reaction Time	0.5	0.9	2.6	0.9	1.6	0.5	1.1	0.8	-0.2
Verbal and Numeric Reasoning (VNR)	1.1	2.5	6.7	2.6	1.6	0.5	1.3	1.5	-1.3
Breast Cancer	1.1	2.7	4.7	-1.8	-2.2	0.3	-1.9	-2.0	0.9
Ovarian Cancer	1.4	1.8	4.8	-1.3	-2.2	-0.1	-1.9	-0.6	-0.3
Prostate Cancer	1.0	1.4	3.0	0.5	1.7	1.2	0.4	0.8	-1.6
Age at First Birth	0.2	0.3	0.9	0.3	-0.6	-0.9	0.3	0.6	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	0.2	-0.2	-0.7	-0.5	-1.2	-0.4
Coronary Artery Disease (CAD)	0.5	0.6	1.4	-1.1	-0.5	0.8	-0.4	1.2	0.2
Crohns Disease (2012)	1.3	2.1	6.7	2.6	1.3	1.5	0.8	-1.1	-0.5
Mean Putamen Volume	0.2	0.2	0.5	0.0	0.7	-0.6	-0.5	-0.2	0.4
Fasting Glucose	1.4	1.7	4.7	-1.7	-1.0	-0.8	-2.2	-0.1	1.0
HbA1C	0.5	0.6	1.6	-0.1	-0.4	-1.2	-0.2	-1.3	0.5
HDL Cholesterol	0.9	1.5	5.1	-1.2	0.0	-2.2	-0.1	0.2	1.6
LDL Cholesterol	0.3	0.5	0.9	-0.5	-0.4	-0.9	-0.8	0.7	-0.9
Lupus	1.0	1.6	3.1	-1.5	-1.8	-1.5	-1.2	-0.6	-0.2
Neuroticism (2016)	0.8	1.1	2.9	1.7	0.8	-0.7	0.9	0.9	-1.1
Primary Biliary Cirrhosis	1.0	1.4	6.1	0.9	0.9	-0.8	0.2	2.5	0.4
Rheumatoid Arthritis	0.1	0.2	0.4	-0.6	-0.2	0.5	-0.1	0.3	0.4
Schizophrenia (2014)	0.7	1.5	3.9	1.0	0.8	-0.7	0.7	1.6	-2.0
Triglycerides	0.1	0.2	0.8	0.9	-0.2	0.6	0.3	-0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.9	1.4	-0.3	-0.5	-0.0	0.6	0.3
Ulcerative Colitis	0.9	1.3	4.9	1.3	0.9	-0.1	0.5	-0.6	-2.2
Blood Eosinophil Count	0.7	5.1	9.2	-2.8	-2.1	-0.5	-2.9	-3.0	0.9
Blood Platelet Count	0.1	1.6	3.6	-0.9	-1.0	0.1	-1.6	-1.9	1.3
Blood Red Count	0.3	3.3	9.3	-1.2	-2.6	-0.3	-3.0	-0.9	1.2
Blood White Count	3.5	26.3	41.5	-6.4	-6.0	-2.6	-5.4	-5.6	3.7
Heel T-Score	0.3	2.8	4.8	2.2	1.9	1.1	1.6	-0.5	-2.1
BMI	0.2	1.3	2.3	-0.6	-1.4	1.0	-1.4	-0.5	1.5
Height	0.2	4.4	15.4	0.3	1.0	-3.9	1.7	-2.5	1.0
Waist Hip Ratio (WHR)	0.7	3.3	8.1	-2.6	-1.9	-0.0	-2.8	0.0	1.1
Systolic Blood Pressure	0.2	1.0	2.8	-0.6	-1.6	0.2	-1.7	-0.7	-0.3
Smoking Status	0.4	0.9	2.2	-0.9	-1.0	-1.5	-0.9	0.1	0.6
Allergy or Eczema	0.5	1.2	4.5	-1.1	-0.7	-0.6	-0.7	-2.1	-0.4
Cardiovascular Disease	0.6	2.0	6.0	-0.5	-1.6	2.5	-1.2	-1.3	0.0
Hypothyroidism (self reported)	0.3	0.6	2.2	0.3	-0.2	-1.5	0.4	-0.7	-1.0
Respiratory disease	0.3	0.7	1.5	0.8	-0.2	0.9	-0.3	-1.2	-1.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.4	-0.6	-0.4	1.5	-1.1	-1.2	-0.3
Lung FEV1/FVC ratio	1.7	8.6	15.9	-3.0	-4.0	-0.6	-3.0	-2.8	3.0
Lung FVC	0.6	3.0	5.2	2.3	1.9	-0.4	2.0	0.6	-2.2
Neuroticism	0.4	1.0	4.8	0.9	-0.0	-0.1	0.4	-0.4	-2.2
Chronotype (morning person)	0.3	0.8	4.1	-0.2	0.5	-0.4	-0.2	-0.0	-2.0
Hair Pigment	0.0	0.7	1.6	0.3	-0.2	-1.1	0.6	1.3	0.9
Tanning	0.1	1.1	2.1	-1.0	-1.1	-1.3	-0.8	-1.4	-0.1
Hand grip strength (left)	0.1	0.4	1.3	0.1	0.2	-0.6	0.1	-1.1	0.8
Number of treatments/medications taken	1.4	2.4	4.2	-0.4	-2.1	2.0	-1.6	-1.9	0.5
Average weekly spirits intake	1.1	1.4	4.8	-0.0	-0.4	1.5	-1.0	-2.2	-0.4
Sensitivity / hurt feelings	0.1	0.2	0.7	-0.4	-0.2	-0.3	-0.2	-0.9	-0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.9	1.4	1.2	0.7	0.2	1.2	-1.0
Hearing difficulty/problems: Yes	0.2	0.4	0.9	-0.3	-0.8	-0.4	-0.4	-0.9	0.4
Relative age of first facial hair	0.4	0.8	1.5	0.6	1.1	0.1	1.2	0.8	1.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.1	0.2	-1.5	-1.0	-0.9	-0.0	0.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	-0.4	-1.0	-0.0	-0.0	0.2	0.9
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	-0.4	-0.8	-0.9	-0.5	-1.0	0.5
Systolic blood pressure, automated reading	0.1	0.3	1.2	-0.0	-0.4	-0.2	-1.1	0.8	-0.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	0.6	0.5	-0.6	0.7	-1.2	-0.5
Angina	0.9	1.2	3.4	-0.3	-1.5	-0.8	-0.8	-1.8	-0.3
Medication for hormone replacement therapy	1.0	1.2	3.3	-0.8	-0.7	0.8	-0.5	-1.8	1.3
Vitamin and mineral supplements	1.0	1.3	2.6	1.1	1.0	1.0	1.1	1.6	-1.0
Supplements: Zinc	0.8	0.9	4.0	0.7	0.6	2.0	0.2	-0.6	0.5
Medication: Co-codamol	0.8	1.0	2.7	0.3	-0.4	-1.6	0.1	-1.4	-0.8
Medication: Metformin	0.8	1.1	3.1	-0.6	-0.6	1.8	-1.5	-0.3	-0.8
Diabetes (father)	0.7	0.8	4.5	0.1	0.4	2.1	0.5	-0.3	0.1
Diabetes (mother)	2.0	2.6	6.9	-1.8	-1.8	-0.3	-2.6	0.9	1.2
Severe depression (siblings)	0.3	0.3	1.1	0.5	-0.1	-0.3	-0.4	-1.1	0.3
Pack years adult smoking proportion	1.4	2.1	3.7	0.9	1.5	0.9	1.8	1.9	1.4
Impedance of leg (right)	0.6	3.1	5.0	2.2	2.1	-0.9	1.7	1.6	-1.6
Leg fat-free mass (left)	0.4	2.3	6.9	-1.5	-0.6	-0.2	-0.9	-1.8	2.6
Trunk fat percentage	0.0	0.1	0.5	0.5	0.1	-0.2	-0.2	-0.2	0.7
Hand grip strength (right)	0.4	1.0	3.0	0.2	0.8	-1.5	0.3	-1.7	0.4
Townsend deprivation index at recruitment	0.2	0.3	0.7	0.6	-0.7	0.3	-0.5	-0.8	0.3
Current tobacco smoking	0.3	0.5	0.8	0.7	0.1	-0.8	0.5	0.7	0.9
Average weekly fortified wine intake	1.8	2.1	5.3	-1.0	-1.8	-0.9	-2.3	-1.4	0.6
Maternal smoking around birth	0.4	0.5	1.4	0.2	-0.5	1.2	-0.4	0.4	-1.0
Fed-up feelings	0.3	0.5	2.1	0.7	-0.0	0.4	0.3	-0.6	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	5.6	2.4	2.4	0.1	1.4	1.3	-0.6
Relative age voice broke	0.8	1.3	3.1	0.4	0.4	-0.6	1.0	1.7	1.7
Taking other prescription medications	1.4	2.2	4.6	-1.1	-1.3	1.3	-2.1	-1.9	-0.0
Age when periods started (menarche)	0.5	1.2	4.0	2.0	1.4	0.6	0.4	0.9	-0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.6	0.4	0.3	-0.3	1.0	-1.6	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	1.0	1.0	0.2	1.1	0.4	-0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.4	-0.5	-0.5	-1.2	-0.3	0.0	1.2
Qualifications: CSEs or equivalent	0.4	0.6	1.8	0.9	-0.4	1.3	-0.1	0.9	0.1
Serious illness, injury or assault to yourself	2.8	3.4	6.5	-2.2	-2.4	0.5	-2.6	-1.6	0.6
High blood pressure	0.3	0.7	2.1	-0.5	-1.4	-0.2	-1.2	-0.3	0.5
Hayfever, allergic rhinitis or eczema	0.6	1.2	5.0	-0.8	-1.1	-0.4	-0.5	-2.2	-0.4
Multivitamins +/- minerals	1.1	1.5	3.0	-1.7	-1.4	-0.3	-1.3	-1.3	0.6
Stomach or abdominal pain in last month	0.2	0.3	0.9	-0.4	-0.6	-0.0	-0.9	0.2	-0.2
Supplements: Glucosamine	0.7	0.9	2.5	0.7	0.2	-1.6	1.4	-0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.4	-1.6	-0.7	1.5	-1.2	-0.3	1.5
Medication: Atenolol	2.3	2.9	5.8	-1.4	-2.4	0.1	-2.0	-2.3	0.6
Medication: Levothyroxine sodium	0.7	1.2	4.3	-0.1	-1.0	-2.1	0.6	-1.2	0.2
Sitting height	0.1	0.8	2.2	0.3	0.3	-1.5	0.8	-0.5	1.4
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	0.1	1.0	0.2	0.1	-0.7	-0.8
High blood pressure (mother)	2.5	3.4	6.9	-2.6	-1.8	-0.9	-2.5	0.3	1.8
Body mass index (BMI)	0.2	1.0	3.2	-0.7	-0.7	0.7	-1.1	-0.2	1.8
Impedance of leg (left)	0.4	1.8	3.3	1.7	1.5	-1.0	0.9	0.5	-1.8
Leg predicted mass (left)	0.4	2.2	6.7	-1.4	-0.6	-0.3	-0.9	-1.8	2.6
Trunk fat mass	0.1	0.6	2.3	0.0	-0.2	-0.5	-0.5	-0.7	1.5
Waist circumference	0.9	3.4	6.7	-1.9	-2.0	-0.4	-2.6	-1.1	2.1
Number of incorrect matches in round	0.7	1.1	2.8	-0.6	-1.7	-1.3	-1.0	0.3	0.8
Past tobacco smoking	0.7	1.3	2.6	1.1	1.0	0.9	1.2	1.6	1.0
Alcohol usually taken with meals	1.5	2.5	5.4	-1.6	-2.3	-1.8	-1.7	-0.6	-0.7
Nervous feelings	0.2	0.3	0.7	0.8	0.3	0.8	0.3	0.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.8	0.2	-0.2	0.4	0.2	-0.8
Hearing difficulty/problems with background noise	0.3	0.5	1.0	1.0	0.5	-0.1	0.9	0.8	0.4
Hair/balding pattern: Pattern 2	1.2	1.6	3.6	1.2	1.0	0.5	1.6	1.9	0.8
Had menopause	0.3	0.4	1.2	-0.4	-0.5	0.5	0.1	-0.6	1.1
Had other major operations	0.7	0.8	2.1	-0.2	-0.9	1.5	-0.9	-0.9	0.4
Forced vital capacity (FVC)	0.4	1.6	2.8	1.7	1.5	-1.1	1.6	-0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	6.8	2.2	2.6	-0.6	2.6	0.8	-1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	3.3	0.4	-0.4	-1.8	0.4	-0.1	-0.2
Qualifications: None of the above	0.5	1.2	2.6	-0.3	0.1	-1.1	0.9	1.6	1.5
Financial difficulties in last 2 years	0.7	0.9	1.9	-0.9	-0.3	-1.2	-1.4	-1.0	0.6
Mouth/teeth dental problems	0.1	0.2	0.9	-0.2	0.1	-0.3	-0.2	1.0	0.0
Heart attack	2.1	2.6	4.7	-2.0	-1.8	-1.3	-2.2	-0.8	1.2
Allergy	0.3	0.6	2.1	0.6	0.8	0.5	0.5	1.4	0.0
Pain all over the body in last month	0.8	0.9	3.0	0.6	1.1	0.6	1.7	-0.1	-0.5
Diabetes (self-reported)	0.6	0.9	1.6	-0.6	-0.9	1.2	-1.2	-1.0	-0.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.3	-1.2	0.0	0.6	0.5	-1.5	0.5
Medication: Ramipril	0.4	0.5	1.5	0.1	-0.1	-0.8	0.7	-1.2	0.6
Medication: Simvastatin	1.9	2.7	5.3	-1.2	-1.1	2.1	-1.5	-2.3	1.3
Fluid intelligence score	0.1	0.1	0.4	0.3	0.3	0.6	-0.2	-0.2	0.3
Illnesses of siblings	2.2	3.0	6.8	2.1	1.4	-1.5	2.6	0.8	-1.5
Neuroticism score	0.2	0.5	1.3	0.8	0.4	0.1	0.7	-0.5	-1.2
Weight	0.4	1.8	6.0	-0.9	-0.7	-0.7	-1.0	-1.4	2.4
Impedance of arm (right)	0.9	4.3	7.3	2.5	2.1	-0.7	2.7	1.8	-1.8
Arm fat percentage (right)	0.1	0.3	1.5	0.3	-0.2	0.4	-0.2	0.3	1.2
Trunk fat-free mass	0.7	3.8	8.0	-1.6	-1.2	-1.3	-1.3	-2.8	2.8
Hip circumference	0.5	2.0	3.6	-1.1	-1.4	-1.4	-1.3	-1.2	1.9
Time employed in main current job	0.5	0.6	1.0	0.5	-0.2	-1.0	1.0	0.7	0.8
Alcohol intake versus 10 years previously	0.3	0.4	2.0	0.1	-1.4	0.4	-0.6	-0.1	0.4
Father’s age at death	0.4	0.6	1.2	0.8	0.8	-0.9	1.1	0.3	0.3
Worrier / anxious feelings	0.1	0.1	0.3	0.2	-0.1	-0.3	0.5	-0.5	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.6	0.1	0.1	0.8	0.3	0.0	0.2
Falls in the last year	0.4	0.6	0.9	0.8	0.4	-0.8	0.9	0.5	-0.9
Hair/balding pattern: Pattern 3	1.4	2.1	4.3	-1.0	-1.7	-2.1	-0.8	-1.8	0.7
Number of live births	0.5	0.7	3.1	-0.7	0.4	1.8	0.5	0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.1	0.7	0.2	-1.4	1.2	-0.6	-0.2
Pulse rate	0.8	1.4	2.7	-0.8	-0.8	1.6	-1.3	-0.1	-1.6
Happiness	0.4	0.5	1.6	0.7	0.8	-0.1	0.2	1.3	-0.3
Noisy workplace	0.4	0.5	2.0	1.4	0.4	-0.2	0.2	-0.6	-0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.7	0.1	0.5	-1.9	-0.4	-0.5	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	1.8	0.3	1.1	1.2	0.3	-1.0	1.4
Mouth/teeth dental problems: Dentures	0.4	0.7	2.2	1.5	0.5	-0.2	0.4	-0.6	-1.0
Asthma	0.2	0.4	1.0	0.3	0.7	1.0	0.5	0.3	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.3	0.6	1.1	0.7	1.1	-0.3	0.6
Medication: Cholesterol lowering	1.8	2.8	6.7	-1.1	-1.8	1.0	-1.9	-2.6	1.1
Depression (self-reported)	0.3	0.4	1.6	-0.2	-0.0	-0.1	-0.5	-1.3	0.6
Medication: Lansoprazole	0.1	0.1	0.4	-0.2	0.2	0.4	-0.6	0.1	0.4
Prospective memory result	0.4	0.5	1.8	-0.6	-0.7	-1.3	0.1	0.6	0.5
Lung cancer (father)	0.8	0.9	2.2	0.7	1.0	0.7	1.1	1.5	-0.3
Illnesses of mother	1.4	1.7	4.2	1.2	1.7	0.6	1.1	0.2	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.4	1.2	0.4	-0.8	1.6	0.3	-0.0
Pulse wave Arterial Stiffness index	0.6	0.7	2.5	0.7	0.4	-1.6	0.1	0.8	0.8
Impedance of arm (left)	1.2	5.4	8.6	2.9	2.5	-0.8	2.9	1.9	-2.1
Arm fat mass (right)	0.1	0.6	3.1	-0.1	-0.2	0.1	-0.3	-0.3	1.8
Trunk predicted mass	0.7	3.9	7.8	-1.6	-1.3	-1.4	-1.4	-2.7	2.8
Standing height	0.3	3.3	8.6	-0.7	0.1	-2.9	0.0	-2.7	1.7
Length of working week for main job	0.8	0.9	1.9	0.9	0.5	-1.4	0.9	1.2	-0.3
Exposure to tobacco smoke at home	0.0	0.0	0.1	-0.2	0.3	0.1	-0.1	0.0	-0.1
Breastfed as a baby	0.4	0.6	2.8	-0.3	-0.1	0.7	-0.2	-1.7	0.2
Tense / ‘highly strung’	1.4	2.2	4.5	2.1	0.9	0.6	1.7	1.6	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.2	0.1	-0.4	-1.1	-0.6	0.2	0.9
Hair/balding pattern: Pattern 4	0.6	1.4	5.2	0.6	1.4	-0.2	0.4	0.6	-2.3
Birth weight of first child	0.1	0.2	0.5	-0.3	0.4	-0.7	0.1	-0.5	0.3
Peak expiratory flow (PEF)	0.2	0.4	1.3	-0.2	-0.8	-0.2	-0.0	-0.1	1.1
Pulse wave reflection index	1.1	1.3	2.7	1.6	1.1	-0.5	1.1	0.6	1.5
Ever highly irritable/argumentative for 2 days	0.6	0.8	2.7	1.1	-0.1	1.6	0.4	-0.2	-0.7
Loud music exposure frequency	0.9	1.0	2.6	0.3	0.6	-1.4	0.7	0.3	1.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.7	-0.2	-0.4	0.3	-0.6	-0.9	-0.2
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.7	-1.0	0.0	0.8	-0.4	-1.7	1.2
Blood clot in the leg (DVT)	1.0	1.4	4.2	-0.2	2.0	-0.1	0.6	1.7	-0.9
Medication: Paracetamol	0.7	1.2	2.5	1.4	-1.3	0.6	-0.1	0.6	1.6
Headache pain in last month	0.1	0.3	0.6	-0.1	-0.6	0.6	-0.8	0.3	-0.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.7	0.5	1.3	-1.2	1.3	1.1	0.3
Glaucoma (self-reported)	0.6	0.7	1.2	-1.1	-0.9	-0.6	-0.8	-0.8	-0.7
Gout (self-reported)	0.4	0.5	1.2	0.3	0.8	-1.1	0.0	-0.4	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.9	-0.1	-0.3	-1.4	0.5	-1.3	-0.9
Medication: Amlodipine	0.6	0.8	2.6	0.2	-1.6	-1.2	-0.7	0.1	-0.7
Medication: Ventolin 100micrograms inhaler	1.0	1.3	5.2	0.6	0.4	2.3	0.3	-0.0	1.3
Birth weight	0.4	1.0	1.9	1.1	0.5	-1.2	0.9	-1.4	0.4
Chronic bronchitis/emphysema (mother)	1.2	1.5	4.0	0.9	0.7	-0.2	1.8	2.0	0.4
High blood pressure (siblings)	1.6	2.3	4.1	-2.0	-1.0	1.4	-1.9	-0.7	1.7
Forced vital capacity (FVC), Best measure	0.4	1.5	3.0	1.7	1.2	-1.0	1.7	0.6	-0.4
Body fat percentage	0.0	0.2	0.8	0.5	0.1	-0.1	-0.2	0.1	0.9
Leg fat percentage (right)	0.2	0.6	1.5	0.8	0.0	0.4	-0.3	1.0	1.2
Arm fat-free mass (right)	0.8	3.9	9.1	-1.9	-1.1	-0.7	-1.6	-2.5	3.0
Exposure to tobacco smoke outside home	1.5	2.0	5.4	1.4	1.4	-0.4	0.6	2.3	-1.4
Comparative body size at age 10	0.1	0.2	0.5	-0.2	0.3	0.2	0.6	-0.6	-0.7
Number of full brothers	0.4	0.5	1.3	-1.0	-0.5	0.3	-1.1	-0.2	0.3
Worry too long after embarrassment	0.1	0.1	0.3	0.6	-0.3	0.2	0.4	0.2	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.4	0.8	0.1	0.1	0.6	0.5
Wheeze or whistling in the chest in last year	0.8	1.4	5.4	-0.7	-0.4	0.7	-0.5	-2.3	1.3
Number of children fathered	1.1	1.2	2.7	-1.0	-1.7	-0.0	-1.5	-1.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	3.4	4.0	14.4	-1.5	-1.5	-0.1	-2.2	-3.8	-0.3
Age at first live birth	0.2	0.3	0.9	0.3	0.1	-0.9	-0.1	-0.3	-0.9
Pulse wave peak to peak time	0.7	0.8	2.2	-0.8	-0.6	1.5	-0.3	-1.1	-0.5
Health satisfaction	0.4	0.5	1.0	-0.5	-1.0	-0.4	-0.8	0.4	0.8
Shortness of breath walking on level ground	0.2	0.2	0.9	0.0	-0.4	-0.9	0.1	0.4	0.3
Qualifications: College or University degree	0.2	0.7	1.4	0.4	1.2	-0.5	1.0	-1.0	0.7
Eye problems/disorders: None of the above	0.4	0.5	1.1	0.2	0.9	0.3	0.3	1.0	1.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.4	0.0	-0.1	-0.3	0.0	1.2	0.5
Emphysema/chronic bronchitis	0.3	0.4	1.1	-0.4	-0.9	-1.0	-0.3	0.2	-0.2
Medication for pain relief, constipation, heartburn	1.4	2.3	6.9	0.4	2.6	-0.5	1.6	1.2	-1.7
Neck or shoulder pain in last month	0.2	0.3	0.5	0.5	0.4	-0.6	0.6	0.7	-0.6
Medication: Blood pressure	0.6	1.0	1.8	-0.2	-1.2	1.4	-1.2	0.6	-0.9
Angina (self-reported)	1.2	1.6	5.2	-0.4	-1.8	-0.3	-1.0	-2.3	-0.4
Migraine (self-reported)	2.1	2.6	6.7	-1.8	-1.7	-0.9	-1.4	-2.6	0.7
Medication: Ibuprofen	0.8	0.9	2.0	1.0	1.1	0.8	1.4	-0.0	0.7
Medication: Allopurinol	0.3	0.3	0.9	-0.0	0.9	-0.2	-0.5	0.2	-0.9
Medication: Omeprazole	0.9	1.1	3.3	-1.1	-1.3	0.6	-1.8	-0.0	0.5
Medication: Seretide 50 evohaler	1.0	1.1	2.2	-0.8	-1.1	1.5	-0.7	-1.4	0.3
Mean time to correctly identify matches	1.1	2.1	3.7	1.9	1.8	-0.6	1.8	1.3	-0.7
Heart disease (mother)	2.8	3.4	6.6	-1.0	-2.4	0.8	-2.6	-2.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	1.2	0.7	0.4	1.2	-0.9	-0.0
Whole body fat mass	0.1	0.6	3.0	-0.2	-0.3	0.0	-0.6	-0.4	1.7
Leg fat mass (right)	0.2	0.6	3.0	-0.2	-0.0	0.4	-0.7	-0.2	1.7
Arm predicted mass (right)	0.7	3.6	7.4	-1.6	-1.1	-0.8	-1.7	-2.6	2.7
Pulse rate, automated reading	0.4	1.1	2.8	-0.7	-1.7	0.8	-1.5	0.7	-0.4
Alcohol intake frequency.	0.2	0.5	1.5	-0.7	-1.2	0.1	-0.7	0.7	-0.3
Comparative height size at age 10	0.2	1.2	3.8	0.4	1.0	-1.9	1.1	-1.0	0.0
Number of full sisters	0.7	0.8	2.6	-0.7	1.2	0.2	0.3	0.5	-1.6
Suffer from ‘nerves’	0.2	0.4	1.3	1.1	0.1	0.5	0.3	-0.2	-0.8
Overall health rating	0.0	0.1	0.4	0.1	-0.2	0.1	-0.4	-0.6	0.1
Chest pain or discomfort	0.9	1.3	4.5	-0.4	-0.4	1.2	-1.1	-2.1	0.0
Had major operations	0.2	0.3	0.7	0.2	0.0	-0.9	-0.2	0.5	0.7
Age at last live birth	0.1	0.1	0.6	-0.3	0.8	-0.1	-0.0	0.0	0.1
Family relationship satisfaction	1.1	1.4	4.9	1.3	0.3	-0.5	1.1	2.2	-0.1
Leg pain on walking	1.2	1.5	3.5	-1.9	-1.4	-0.9	-1.1	0.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	4.2	-0.6	-0.9	2.0	0.1	0.1	-0.0
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.9	-1.0	-0.9	-0.4	-0.5	-0.3	0.9
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	6.1	1.5	0.4	-0.3	1.0	1.5	-2.5
Medication: Aspirin	2.1	2.7	7.8	-1.0	-2.8	-0.6	-2.0	-1.4	1.0
Supplements: Vitamin C	1.4	1.6	3.8	-0.0	-0.7	-2.0	-0.5	-1.5	1.8
Knee pain experienced in last month	0.2	0.3	0.9	0.2	-1.0	-0.2	0.6	0.8	-0.1
Hypertension (Self-reported)	0.4	1.2	3.4	-0.9	-1.8	-0.2	-1.4	-0.5	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	9.5	-0.4	0.5	3.1	-0.1	0.9	-1.7
Illnesses of father: Heart disease	0.7	1.0	2.2	-1.3	-1.5	0.9	-1.0	0.1	0.2
Illnesses of siblings: Diabetes	1.5	1.8	5.3	-0.5	-0.5	2.3	-0.5	-1.4	1.7
Smoking status: Previous	0.3	0.4	1.4	-0.2	-0.5	-0.1	-0.5	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.5	-0.4	-0.1	-0.9	-0.9	-2.1	1.3
Whole body fat-free mass	0.6	3.5	8.3	-1.6	-1.1	-0.9	-1.3	-2.5	2.9
Leg fat-free mass (right)	0.6	3.1	6.9	-1.8	-1.0	-0.3	-1.2	-2.4	2.6
Arm fat percentage (left)	0.1	0.3	1.7	0.5	0.0	0.4	-0.1	0.2	1.3
Average weekly red wine intake	1.4	2.0	4.6	-1.8	-1.3	-1.2	-2.1	-0.9	-0.6
Handedness (chirality/laterality): Left-handed	0.9	1.0	4.1	-0.9	-0.5	-0.7	-0.2	0.7	2.0
Mood swings	0.2	0.3	1.0	-0.2	-1.0	-0.4	-0.6	0.4	-0.4
Loneliness, isolation	1.5	2.1	5.9	2.4	1.6	-0.7	1.8	0.3	-0.7
Long-standing illness, disability or infirmity	0.1	0.2	0.5	0.1	-0.5	0.4	-0.7	-0.2	-0.1
Ever had bowel cancer screening	0.5	0.6	1.5	0.3	-1.2	-0.6	-0.5	-1.2	-0.4
Diabetes diagnosed by doctor	1.3	2.2	4.6	-1.5	-1.5	1.1	-2.2	-1.6	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.2	-1.5	-0.9	-0.2	-1.5	-0.0	0.0
Friendships satisfaction	1.4	1.8	4.5	2.1	0.8	0.7	1.5	1.6	-0.3
Qualifications: nursing, teaching	1.1	1.8	4.6	-2.0	-1.1	0.1	-2.2	-0.6	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.4	-0.1	0.4	-0.6	0.1	0.5	0.1
Eye problems/disorders: Cataract	1.3	1.5	4.5	0.2	-2.1	-1.5	-1.0	-1.1	0.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.6	-1.0	-1.6	0.4	-1.1	-1.1	-0.5
Medication for cholesterol	2.4	3.6	7.7	1.7	2.2	-1.2	1.5	2.8	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.7	-0.6	-1.5	-1.9	-1.2	0.9	-0.6
Back pain experienced in last month	0.2	0.3	0.5	0.7	-0.7	-0.2	0.7	-0.7	-0.1
Mineral and other dietary supplements	1.6	2.1	7.3	0.8	1.2	2.7	0.6	1.6	-0.6
Breast cancer (self-reported)	0.9	1.1	3.3	-0.9	-0.7	-1.2	-1.8	-0.3	-0.8
Asthma (self-reported)	0.2	0.5	1.7	0.1	0.6	1.3	0.4	-0.1	0.9
Osteoporosis (self-reported)	0.7	0.9	1.9	-1.4	0.2	1.3	-0.6	-0.8	-0.9
Osteoarthritis (self-reported)	2.6	3.4	8.4	2.9	0.5	-1.1	1.8	1.9	-1.9
Medication: Aspirin	2.4	3.1	6.5	-1.2	-2.5	-0.6	-2.3	-1.7	1.5
Medication: Gliclazide	0.8	1.0	3.7	0.5	0.3	1.9	0.3	1.2	0.2
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	0.4	1.2	-0.3	1.2	1.1	-0.1
Smoking status: Current	0.2	0.3	1.3	0.1	-0.2	-1.1	-0.1	0.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	7.0	1.8	0.9	-0.1	2.3	2.6	-0.1
Whole body water mass	0.7	3.7	8.5	-1.7	-1.3	-0.8	-1.4	-2.6	2.9
Leg predicted mass (right)	0.6	3.0	6.7	-1.8	-1.0	-0.3	-1.3	-2.4	2.6
Arm fat mass (left)	0.2	0.8	4.0	-0.3	-0.5	-0.1	-0.6	-0.5	2.0
Number of self-reported non-cancer illnesses	1.7	2.9	5.6	-0.4	-2.4	1.7	-2.2	-2.0	0.2
Average weekly champagne plus white wine intake	0.3	0.4	0.9	-0.2	0.3	-0.6	0.4	0.7	-1.0
Miserableness	0.8	1.4	4.8	1.5	0.2	-0.2	0.6	0.9	-2.2
Guilty feelings	0.4	0.6	1.7	0.4	0.7	-1.3	0.9	-0.6	0.3
Wears glasses or contact lenses	1.3	1.5	4.8	0.6	-0.2	-2.2	1.0	-1.5	-0.4
Ever taken oral contraceptive pill	0.8	0.9	2.2	-0.8	-0.3	1.0	0.2	-1.2	-1.5
Hearing aid user	0.5	0.6	1.8	0.7	0.1	0.8	0.3	0.7	-1.4
Mother’s age at death	2.5	3.1	5.2	2.0	1.5	1.2	2.3	2.3	-0.8
Financial situation satisfaction	0.1	0.2	0.5	0.2	0.2	0.2	-0.6	0.7	0.3
Tinnitus: Yes, now most or all of the time	2.3	2.7	5.4	-1.3	-2.3	2.3	-1.9	0.0	-0.8
Commuting to job workplace: Public transport	0.3	0.3	1.5	1.2	0.3	0.0	0.5	0.4	-0.3
Eye problems/disorders: Glaucoma	0.7	0.9	1.3	-0.9	-0.8	-1.1	-0.6	-1.0	-1.1
Medication: Blood pressure	2.0	3.8	5.8	-2.2	-2.4	-0.2	-1.9	-2.4	1.7
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.9	-0.8	-1.4	-0.2	-0.8	0.2	0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.7	6.2	-0.2	-1.1	-2.5	-0.4	-1.5	0.7
High cholesterol (Self-reported)	0.6	1.1	2.6	0.9	-1.4	1.1	-0.3	-1.6	-0.1
Medication: Bendroflumethiazide	1.2	1.9	3.0	-1.3	-1.3	-0.1	-1.7	-1.4	1.7
Medication: Paracetamol	0.9	1.4	3.7	0.8	-1.9	0.1	-0.5	-0.1	1.9
Medication: Lisinopril	2.4	3.1	6.0	-2.0	-2.0	1.7	-2.4	-0.9	1.0
Medication: Atorvastatin	0.6	0.8	1.9	0.6	-1.1	1.0	-0.1	-1.4	-0.6
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.5	-0.8	-0.0	-0.2	0.7	-0.4
Alcohol drinker status: Never	0.6	0.7	1.3	0.8	-0.6	0.4	0.6	1.1	-1.1
Ever smoked	0.5	0.8	1.7	-0.8	-0.8	-0.8	-1.3	-1.0	-0.5
Basal metabolic rate	0.6	3.0	7.6	-1.5	-1.0	-0.8	-1.3	-2.3	2.8
Leg fat percentage (left)	0.1	0.4	1.3	0.4	-0.5	0.4	-0.8	0.2	1.1
Arm fat-free mass (left)	0.8	4.1	8.2	-2.2	-1.4	-0.5	-1.8	-2.5	2.9
Number of operations (self-reported)	0.6	0.8	1.7	-0.3	-1.1	1.1	-0.6	-1.3	0.6
Average weekly beer plus cider intake	0.4	0.6	1.1	0.9	0.5	0.9	1.0	0.3	0.8
Irritability	0.3	0.6	1.5	0.7	0.8	1.2	0.9	-0.4	-0.0
Risk taking	0.3	0.5	1.1	0.8	0.6	1.0	0.0	0.9	-0.3
Ever had prostate specific antigen (PSA) test	1.8	2.0	7.4	-0.1	-0.7	-0.7	-0.4	-1.9	-2.7
Fractured/broken bones in last 5 years	0.5	0.6	2.4	0.6	0.4	-0.9	0.2	1.6	0.1
Age started oral contraceptive pill	0.3	0.4	1.2	1.1	0.1	0.2	0.7	0.4	-0.5
Diastolic blood pressure, automated reading	0.2	0.5	1.5	0.4	-0.3	1.2	-1.1	0.2	0.1
Ever depressed for a whole week	0.3	0.4	0.8	0.8	-0.2	-0.8	0.6	0.2	-0.9
Unable to work because of sickness or disability	1.8	2.4	6.3	1.0	1.7	2.5	0.8	0.6	-1.8
Commuting to job workplace: Cycle	1.1	1.4	3.8	1.9	0.5	-0.5	0.6	1.6	-1.0
Myopia	0.6	0.9	4.5	0.6	-0.3	2.1	-0.7	-0.2	0.1
Vascular/heart problems diagnosed by doctor	0.6	1.5	3.3	1.1	1.8	-0.0	1.8	1.0	-0.7
Cholesterol lowering medication	0.6	0.9	3.4	-0.4	-1.0	1.8	-0.4	-0.5	0.5
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.9	-1.3	-1.7	0.9	-2.0	-0.9	0.3
Pain experienced in last month	0.3	0.5	1.7	-0.4	-0.0	0.1	-1.3	-1.0	-0.3
Supplements: Calcium	0.3	0.3	1.1	-1.1	-0.6	-0.4	-0.3	0.5	0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	-0.7	-0.3	0.4	-0.7	-0.9	-1.1
Heart attack/myocardial infarction (self-reported)	1.2	1.6	2.7	-1.3	-1.5	-1.3	-1.6	-0.3	0.9
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.0	-0.3	2.0	0.3	0.6	1.6	-1.0
Heart disease (siblings)	1.3	1.6	5.2	-0.1	-1.0	1.5	-1.0	0.2	-2.3
Alcohol drinker status: Previous	0.5	0.5	1.5	-0.9	0.3	1.2	-0.3	-0.2	-0.9
Pack years of smoking	1.2	1.7	3.1	0.7	1.4	0.9	1.7	1.7	1.1
Impedance of whole body	0.7	3.7	5.2	2.3	2.2	-0.7	2.1	1.6	-2.1
Leg fat mass (left)	0.2	0.8	3.1	-0.3	-0.3	0.4	-1.0	-0.6	1.8
Arm predicted mass (left)	0.8	3.9	8.0	-2.0	-1.4	-0.6	-1.7	-2.5	2.8