Hub : Genes

COX6C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1800	0.0860	0.0073	0.062	NA	0.069	NA	0.075	1.0e-03	NA	5.3e-04	NA	3.1e-04
2	NTR	Blood	0.2399	0.0363	0.0000	0.330	0.315	0.330	0.326	0.329	2.5e-110	3.0e-104	3.2e-110	1.2e-108	4.6e-110
3	YFS	Blood	0.0209	0.0095	0.0019	0.012	0.009	0.012	0.010	0.011	6.8e-05	4.2e-04	7.9e-05	1.9e-04	1.5e-04
4	TCGA	Glioblastoma Multiforme	0.0750	0.0530	0.0075	0.029	0.040	0.020	NA	0.017	4.5e-02	2.3e-02	7.8e-02	NA	9.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.0	0.0	0.1	0.0	0.3	-0.0	-0.2
Bipolar Disorder or Schizophrenia	0.2	0.5	0.5	-0.7	-0.7	-0.6	0.7
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	0.2	-0.1	0.1	-0.1
Depression (Nagel 2018)	0.4	0.7	1.2	1.1	0.7	0.9	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.8	0.6	0.8	0.9	-0.9
Neuroticism (Nagel 2018)	0.3	0.7	1.0	-0.8	-1.0	-0.7	0.8
Schizophrenia (2018)	0.5	1.0	1.3	-0.9	-1.1	-0.8	1.1
Schizophrenia vs Biploar Disorder	3.3	4.4	5.5	-1.6	-2.4	-2.1	2.3
Worry (Nagel 2018)	0.5	1.1	1.5	-1.2	-1.1	-1.0	1.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	0.3	0.0	0.3	0.3
Alzheimer’s Disease (in father)	1.3	1.4	1.8	-1.3	-1.0	-1.3	1.0
Alzheimer’s Disease (including proxy)	0.1	0.1	0.1	-0.1	-0.3	-0.3	0.4
Crohns Disease (2017)	0.4	1.0	1.6	0.9	1.3	0.6	-1.0
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	0.2	0.3	-0.4	-0.1
Ulcerative Colitis (UC)	0.3	0.6	1.0	-0.5	-0.8	-1.0	0.8
Major Depression (MDD)	0.3	0.3	0.7	-0.5	-0.5	-0.2	0.8
Reaction Time	0.1	0.2	0.6	0.0	0.2	0.8	-0.3
Verbal and Numeric Reasoning (VNR)	1.0	2.5	2.6	1.6	1.5	1.6	-1.6
Breast Cancer	0.7	1.6	2.0	-1.1	-1.3	-1.4	1.3
Ovarian Cancer	0.7	1.0	1.3	1.1	0.9	1.1	-0.8
Prostate Cancer	0.2	0.3	0.4	-0.6	-0.6	-0.4	0.5
Age at First Birth	1.7	2.5	3.5	1.6	1.4	1.9	-1.3
Bipolar Disorder (2011)	0.4	0.4	0.5	0.6	0.7	0.6	-0.7
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	-0.5	-1.0	-0.6	1.1
Coronary Artery Disease (CAD)	0.2	0.3	0.5	0.5	0.7	0.5	-0.5
Crohns Disease (2012)	0.0	0.0	0.1	0.0	0.3	-0.1	0.1
Mean Putamen Volume	0.2	0.2	0.3	-0.3	-0.5	-0.2	0.6
Fasting Glucose	0.5	0.5	0.9	-1.0	-0.9	-0.2	0.6
HbA1C	0.4	0.5	0.7	0.6	0.8	0.8	-0.5
HDL Cholesterol	1.6	2.7	3.1	1.6	1.5	1.7	-1.8
LDL Cholesterol	2.3	3.6	5.9	1.9	1.7	2.4	-1.3
Lupus	1.0	1.5	2.3	-0.8	-1.3	-1.5	1.1
Neuroticism (2016)	0.2	0.3	0.7	-0.0	0.6	0.8	-0.6
Primary Biliary Cirrhosis	1.3	1.9	2.6	-1.3	-1.6	-1.2	1.4
Rheumatoid Arthritis	2.1	2.9	3.8	1.8	1.6	1.5	-2.0
Schizophrenia (2014)	1.1	2.4	3.0	-1.3	-1.7	-1.5	1.7
Triglycerides	0.6	1.0	1.4	-1.0	-1.1	-0.5	1.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.1	0.2	-0.1	-0.5
Ulcerative Colitis	0.6	0.9	1.6	-0.7	-0.9	-1.3	0.8
Blood Eosinophil Count	0.1	0.7	0.9	-0.7	-0.9	-0.9	0.8
Blood Platelet Count	0.2	2.5	3.4	1.9	1.8	0.5	-1.8
Blood Red Count	0.5	4.8	7.5	2.7	2.5	1.0	-2.2
Blood White Count	0.4	2.7	4.6	1.4	2.1	0.6	-2.0
Heel T-Score	3.1	24.6	28.0	5.3	4.3	5.0	-5.2
BMI	0.6	3.2	4.9	1.8	1.8	1.2	-2.2
Height	0.3	6.5	9.5	-2.4	-2.9	-1.5	3.1
Waist Hip Ratio (WHR)	0.6	2.9	4.6	-1.6	-1.8	-2.1	1.2
Systolic Blood Pressure	0.2	1.0	1.8	0.6	1.3	0.5	-1.3
Smoking Status	0.1	0.2	0.5	-0.1	0.5	0.2	-0.7
Allergy or Eczema	0.3	0.7	1.5	0.8	0.8	1.2	-0.5
Cardiovascular Disease	0.0	0.0	0.1	0.1	0.2	-0.1	-0.3
Hypothyroidism (self reported)	0.2	0.4	0.8	-0.1	-0.9	-0.8	0.3
Respiratory disease	0.3	0.7	1.5	-0.4	-0.9	-0.8	1.2
Type 2 Diabetes (T2D) (2018)	2.8	5.3	6.2	-2.1	-2.5	-2.3	2.2
Lung FEV1/FVC ratio	0.3	1.7	3.2	1.3	1.3	0.6	-1.8
Lung FVC	0.3	1.4	2.4	-1.0	-1.3	-0.6	1.6
Neuroticism	0.1	0.2	0.3	-0.4	-0.5	-0.1	0.4
Chronotype (morning person)	0.1	0.2	0.3	0.5	0.3	0.5	-0.2
Hair Pigment	0.1	3.2	3.5	-1.8	-1.9	-1.6	1.9
Tanning	0.0	0.3	0.5	0.3	0.7	0.6	-0.7
Hand grip strength (left)	0.1	0.2	0.4	-0.1	-0.6	-0.7	0.4
Number of treatments/medications taken	0.1	0.1	0.2	-0.2	-0.1	-0.5	-0.3
Average weekly spirits intake	2.5	3.1	3.4	-1.7	-1.8	-1.7	1.8
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.4	-0.3	-0.6	0.2
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.1	1.5	1.1	1.4	-1.0
Hearing difficulty/problems: Yes	0.1	0.1	0.4	0.1	0.1	0.6	0.2
Relative age of first facial hair	0.0	0.0	0.1	0.3	0.0	0.2	-0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	-0.4	-0.5	-0.0	0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.1	-0.1	-0.6	0.0
Ever had hysterectomy (womb removed)	1.8	2.1	2.8	-1.3	-1.2	-1.7	1.5
Systolic blood pressure, automated reading	0.0	0.1	0.3	-0.1	0.4	-0.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.1	-1.0	-1.0	-0.7	0.9
Angina	0.0	0.0	0.0	-0.2	0.2	-0.1	-0.2
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1
Vitamin and mineral supplements	1.8	2.4	2.7	-1.4	-1.6	-1.6	1.6
Supplements: Zinc	2.3	2.5	3.3	1.1	1.5	1.7	-1.8
Medication: Co-codamol	0.4	0.5	0.8	-0.7	-0.9	-0.4	0.7
Medication: Metformin	0.4	0.5	0.6	-0.7	-0.8	-0.8	0.7
Diabetes (father)	0.7	0.8	1.5	-1.0	-0.7	-1.2	0.5
Diabetes (mother)	0.0	0.0	0.1	-0.0	-0.2	-0.1	-0.2
Severe depression (siblings)	0.3	0.3	0.9	0.0	0.6	0.3	-0.9
Pack years adult smoking proportion	0.7	1.0	1.1	-1.1	-1.1	-1.0	0.8
Impedance of leg (right)	0.3	1.4	2.1	-1.1	-1.3	-0.8	1.4
Leg fat-free mass (left)	0.0	0.1	0.2	0.2	0.2	0.1	-0.4
Trunk fat percentage	0.0	0.1	0.1	0.0	0.1	-0.3	-0.4
Hand grip strength (right)	0.0	0.1	0.2	0.2	-0.2	-0.5	-0.1
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.4	0.2	0.4	-0.0
Current tobacco smoking	0.1	0.2	0.5	0.3	0.6	0.1	-0.7
Average weekly fortified wine intake	0.1	0.1	0.1	-0.4	-0.0	0.4	0.0
Maternal smoking around birth	0.4	0.6	0.9	-0.9	-0.8	-0.2	1.0
Fed-up feelings	1.2	2.1	2.5	1.5	1.4	1.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	2.7	1.6	1.3	1.6	-1.2
Relative age voice broke	0.1	0.1	0.2	0.2	0.4	0.2	-0.4
Taking other prescription medications	0.3	0.5	0.8	0.7	0.7	0.5	-0.9
Age when periods started (menarche)	0.5	1.1	1.5	-1.2	-1.1	-0.6	1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	-0.5	-0.6	-1.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.4	6.5	1.9	1.9	2.0	-2.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.6	-0.5	0.4	0.4
Qualifications: CSEs or equivalent	1.5	2.0	2.7	1.2	1.6	1.3	-1.5
Serious illness, injury or assault to yourself	0.2	0.3	0.4	0.3	0.7	0.7	-0.4
High blood pressure	0.5	1.4	2.3	-1.1	-1.1	-1.5	0.9
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.2	1.0	1.0	1.5	-0.7
Multivitamins +/- minerals	0.8	1.1	1.3	1.1	0.9	0.9	-1.1
Stomach or abdominal pain in last month	0.0	0.1	0.1	0.2	0.1	0.3	-0.2
Supplements: Glucosamine	0.0	0.0	0.1	-0.3	0.0	-0.0	-0.2
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.2	0.0	0.0	0.1
Medication: Atenolol	0.6	0.7	1.5	-1.1	-0.6	-1.2	0.1
Medication: Levothyroxine sodium	0.2	0.4	0.9	1.0	0.2	0.5	-0.4
Sitting height	0.2	1.6	2.7	-1.1	-1.5	-0.2	1.6
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.2
High blood pressure (mother)	0.8	1.1	1.7	-0.6	-1.3	-1.1	1.0
Body mass index (BMI)	0.2	0.9	1.9	0.9	1.0	0.2	-1.4
Impedance of leg (left)	0.2	1.2	1.9	-1.1	-1.1	-0.5	1.4
Leg predicted mass (left)	0.0	0.1	0.2	0.2	0.1	0.1	-0.4
Trunk fat mass	0.0	0.1	0.2	-0.1	-0.1	-0.5	-0.3
Waist circumference	0.1	0.4	1.2	-0.4	-0.5	-1.1	-0.1
Number of incorrect matches in round	0.2	0.4	0.9	-0.6	-0.4	-0.9	-0.0
Past tobacco smoking	0.1	0.1	0.4	0.6	0.2	0.3	-0.3
Alcohol usually taken with meals	2.3	3.8	5.3	1.9	1.9	2.3	-1.7
Nervous feelings	0.5	0.8	1.2	-1.1	-0.9	-0.8	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.0	-0.3	0.3	0.5
Hearing difficulty/problems with background noise	0.4	0.6	0.9	0.4	0.9	0.9	-0.9
Hair/balding pattern: Pattern 2	1.5	2.0	2.1	-1.4	-1.4	-1.4	1.4
Had menopause	0.4	0.5	0.5	-0.7	-0.7	-0.7	0.7
Had other major operations	2.6	3.2	3.8	1.7	1.8	2.0	-1.8
Forced vital capacity (FVC)	0.2	0.8	1.6	-0.7	-1.0	-0.0	1.2
Heel bone mineral density (BMD) T-score, automated (right)	2.7	6.2	8.1	2.4	2.3	2.4	-2.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.7	0.6	0.4	1.3	-0.3
Qualifications: None of the above	0.1	0.1	0.4	0.7	0.2	0.1	-0.3
Financial difficulties in last 2 years	1.1	1.4	1.9	1.2	1.1	1.0	-1.4
Mouth/teeth dental problems	0.4	0.6	1.2	0.8	0.7	0.0	-1.1
Heart attack	2.3	2.9	3.7	-1.9	-1.8	-1.2	1.9
Allergy	1.5	3.5	5.2	-2.0	-1.8	-2.3	1.4
Pain all over the body in last month	0.1	0.1	0.3	0.1	-0.1	0.6	0.2
Diabetes (self-reported)	1.2	1.8	2.3	-1.2	-1.4	-1.5	1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.6	-0.6	-0.7	-0.8	0.8
Medication: Ramipril	2.7	3.4	4.2	-1.6	-2.0	-1.7	2.0
Medication: Simvastatin	1.1	1.6	3.8	-1.0	-1.1	-1.9	0.5
Fluid intelligence score	1.5	3.1	3.6	1.8	1.6	1.9	-1.8
Illnesses of siblings	0.3	0.5	1.4	0.4	0.0	1.2	0.5
Neuroticism score	0.0	0.0	0.1	0.1	-0.1	0.4	0.0
Weight	0.0	0.1	0.2	0.1	0.0	-0.2	-0.4
Impedance of arm (right)	0.1	0.5	1.0	-0.8	-0.7	-0.2	1.0
Arm fat percentage (right)	0.2	0.7	1.5	0.7	0.9	0.1	-1.2
Trunk fat-free mass	0.0	0.0	0.1	-0.2	-0.3	-0.1	0.1
Hip circumference	0.0	0.1	0.3	0.3	0.3	0.1	-0.6
Time employed in main current job	3.0	3.4	3.6	-1.9	-1.9	-1.7	1.9
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.2	0.6	0.2	-0.6
Father’s age at death	0.3	0.5	0.6	-0.5	-0.8	-0.6	0.7
Worrier / anxious feelings	0.4	0.7	1.3	0.5	0.7	1.1	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	0.9	0.7	0.8	-0.7
Falls in the last year	0.7	1.0	1.3	1.1	1.0	1.0	-0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	0.6	0.7	-0.0	-0.7
Number of live births	0.2	0.3	0.5	0.5	0.3	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	-0.1	-0.4	0.2	0.6
Pulse rate	0.0	0.0	0.1	0.2	0.3	0.3	-0.1
Happiness	4.0	4.8	5.9	-2.0	-2.4	-2.1	2.3
Noisy workplace	0.6	0.7	1.0	-0.8	-0.7	-1.0	0.9
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	-0.5	-0.1	-0.2	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.1	-0.2	-0.3	0.2
Mouth/teeth dental problems: Dentures	1.6	2.6	4.9	-1.7	-1.6	-0.5	2.2
Asthma	0.1	0.2	0.5	0.7	0.2	0.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	1.6	1.3	1.2	1.1	-1.0
Medication: Cholesterol lowering	0.1	0.2	0.6	-0.3	-0.2	-0.8	-0.2
Depression (self-reported)	0.5	0.6	0.9	1.0	0.8	0.6	-0.7
Medication: Lansoprazole	2.4	2.7	4.0	-1.3	-1.9	-1.3	2.0
Prospective memory result	2.7	3.3	4.4	-1.6	-1.8	-1.8	2.1
Lung cancer (father)	0.1	0.1	0.3	0.2	0.1	-0.0	-0.5
Illnesses of mother	0.5	0.6	1.0	-1.0	-0.6	-0.5	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	0.7	0.2	0.6	-0.1
Pulse wave Arterial Stiffness index	1.1	1.3	2.5	1.1	0.9	1.6	-0.6
Impedance of arm (left)	0.1	0.5	1.0	-0.8	-0.6	-0.1	1.0
Arm fat mass (right)	0.1	0.6	1.3	0.6	0.8	0.1	-1.1
Trunk predicted mass	0.0	0.1	0.1	-0.3	-0.3	-0.1	0.1
Standing height	0.3	2.6	3.7	-1.6	-1.9	-0.6	1.9
Length of working week for main job	0.3	0.4	0.8	0.3	0.6	0.9	-0.5
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.5	-0.3	-0.1	0.5
Breastfed as a baby	0.1	0.1	0.2	0.3	0.3	0.4	-0.2
Tense / ‘highly strung’	0.5	0.8	1.2	-1.1	-0.9	-0.7	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.3	-0.2	-0.1	0.1
Hair/balding pattern: Pattern 4	0.4	0.9	1.4	-1.2	-1.0	-0.3	1.1
Birth weight of first child	1.1	2.1	2.4	1.3	1.6	1.5	-1.5
Peak expiratory flow (PEF)	0.3	0.7	1.5	1.2	0.6	0.8	-0.6
Pulse wave reflection index	1.2	1.5	2.3	1.0	1.2	1.5	-1.1
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	0.0	-0.4	0.3	0.6
Loud music exposure frequency	0.1	0.1	0.4	0.3	0.4	0.6	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.1	0.1	0.8	0.6	-1.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.5	-0.4	-0.2	0.4
Blood clot in the leg (DVT)	0.7	0.9	1.2	1.1	0.8	0.8	-1.1
Medication: Paracetamol	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.3
Headache pain in last month	0.1	0.2	0.3	0.3	0.4	0.5	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	0.3	0.4	1.0	-0.0
Glaucoma (self-reported)	2.5	3.0	3.5	-1.8	-1.6	-1.5	1.9
Gout (self-reported)	0.3	0.4	0.9	-0.6	-0.4	-1.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	0.3	-0.4	-0.2	0.0
Medication: Amlodipine	0.1	0.1	0.5	-0.1	-0.1	-0.7	0.1
Medication: Ventolin 100micrograms inhaler	1.1	1.3	1.9	-1.2	-1.2	-0.9	1.4
Birth weight	2.1	4.5	5.4	2.1	2.3	1.6	-2.3
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	-0.1	0.3	-0.4	-0.5
High blood pressure (siblings)	1.4	2.0	3.1	-1.7	-1.2	-1.8	0.9
Forced vital capacity (FVC), Best measure	0.0	0.1	0.3	0.1	-0.3	0.4	0.5
Body fat percentage	0.0	0.1	0.2	0.1	0.2	-0.4	-0.5
Leg fat percentage (right)	0.0	0.2	0.6	0.0	0.0	-0.7	-0.4
Arm fat-free mass (right)	0.0	0.0	0.1	-0.1	-0.2	-0.1	-0.1
Exposure to tobacco smoke outside home	0.0	0.1	0.1	0.3	0.2	0.1	-0.3
Comparative body size at age 10	0.0	0.1	0.4	-0.3	-0.1	-0.6	-0.2
Number of full brothers	1.3	1.7	2.0	1.1	1.4	1.3	-1.4
Worry too long after embarrassment	0.3	0.5	0.7	0.6	0.8	0.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.1	0.9	0.9	1.0	-1.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.6	0.4	0.2	-0.3
Number of children fathered	1.6	1.8	2.5	1.6	1.2	0.8	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	3.6	-1.6	-1.6	-1.9	1.5
Age at first live birth	0.1	0.1	0.2	0.5	-0.3	0.1	0.3
Pulse wave peak to peak time	1.7	2.0	3.4	-1.4	-1.3	-1.8	1.0
Health satisfaction	0.9	1.1	1.8	1.1	0.9	1.3	-0.9
Shortness of breath walking on level ground	2.2	2.7	3.5	-1.4	-1.9	-1.3	1.9
Qualifications: College or University degree	0.2	0.6	1.0	-1.0	-0.8	-0.7	0.6
Eye problems/disorders: None of the above	0.7	0.8	1.3	1.2	0.7	0.7	-0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.0	-1.0	-1.0	-0.7	0.8
Emphysema/chronic bronchitis	0.0	0.1	0.2	-0.1	0.1	-0.4	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	0.3	0.3	0.9	-0.1
Neck or shoulder pain in last month	0.1	0.1	0.3	0.2	-0.0	0.6	-0.1
Medication: Blood pressure	0.0	0.1	0.2	-0.0	0.0	-0.5	-0.3
Angina (self-reported)	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.3
Migraine (self-reported)	0.5	0.7	0.9	-1.0	-0.9	-0.6	0.6
Medication: Ibuprofen	1.1	1.3	1.7	1.1	1.3	1.3	-0.8
Medication: Allopurinol	0.3	0.4	1.0	0.3	0.7	0.0	-1.0
Medication: Omeprazole	2.3	2.7	4.2	1.9	1.4	2.0	-1.1
Medication: Seretide 50 evohaler	0.4	0.5	0.9	0.5	0.8	1.0	-0.4
Mean time to correctly identify matches	0.7	1.4	1.7	-1.3	-1.3	-1.0	1.2
Heart disease (mother)	0.2	0.2	0.6	-0.1	-0.4	-0.8	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	0.4	0.9	0.7	-0.7
Whole body fat mass	0.0	0.1	0.3	0.1	0.2	-0.3	-0.5
Leg fat mass (right)	0.1	0.2	0.6	0.4	0.4	-0.3	-0.8
Arm predicted mass (right)	0.0	0.0	0.0	-0.0	-0.2	-0.1	-0.1
Pulse rate, automated reading	0.1	0.3	0.4	0.6	0.5	0.4	-0.5
Alcohol intake frequency.	0.4	1.0	1.7	1.3	0.9	0.8	-0.9
Comparative height size at age 10	0.7	4.1	5.4	-1.9	-2.3	-1.6	2.2
Number of full sisters	0.2	0.2	0.4	0.4	0.6	0.2	-0.7
Suffer from ‘nerves’	0.9	1.4	2.0	-1.1	-1.4	-1.0	1.3
Overall health rating	0.0	0.0	0.1	0.1	-0.2	-0.3	0.0
Chest pain or discomfort	0.0	0.0	0.1	-0.2	0.1	0.1	-0.2
Had major operations	1.0	1.2	1.8	0.7	1.3	0.9	-1.4
Age at last live birth	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.1
Family relationship satisfaction	1.8	2.2	3.0	-1.4	-1.7	-1.4	1.4
Leg pain on walking	2.3	2.9	3.2	1.8	1.6	1.7	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.3	-0.1	-0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	-0.4	-0.6	-0.7	0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.5	-0.5	-0.7	-0.6	0.6
Medication: Aspirin	0.2	0.3	0.7	-0.4	-0.1	-0.9	-0.3
Supplements: Vitamin C	0.9	1.0	1.4	0.7	0.9	1.2	-1.2
Knee pain experienced in last month	0.1	0.1	0.3	0.5	0.2	0.2	0.0
Hypertension (Self-reported)	0.5	1.3	2.2	-1.1	-1.1	-1.5	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	0.8	0.5	0.6	-0.2
Illnesses of father: Heart disease	0.1	0.2	0.4	0.4	0.6	0.0	-0.4
Illnesses of siblings: Diabetes	0.2	0.3	0.6	-0.3	0.1	-0.8	-0.7
Smoking status: Previous	0.4	0.5	0.7	-0.8	-0.6	-0.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	-0.6	-0.6	-0.4	0.3
Whole body fat-free mass	0.0	0.0	0.0	0.0	-0.1	0.0	-0.2
Leg fat-free mass (right)	0.0	0.1	0.2	0.3	0.2	0.3	-0.5
Arm fat percentage (left)	0.1	0.5	1.2	0.6	0.8	0.0	-1.1
Average weekly red wine intake	0.2	0.3	0.6	-0.5	-0.6	-0.3	0.8
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	0.1	0.2	0.1	-0.2
Mood swings	0.1	0.1	0.3	0.4	0.2	0.2	-0.5
Loneliness, isolation	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1
Long-standing illness, disability or infirmity	0.9	1.4	1.9	1.2	1.1	1.4	-0.9
Ever had bowel cancer screening	0.2	0.3	0.4	-0.4	-0.4	-0.6	0.7
Diabetes diagnosed by doctor	1.2	2.0	2.5	-1.4	-1.5	-1.6	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.2	-0.2	0.2	0.1
Friendships satisfaction	1.1	1.4	2.0	-1.0	-1.4	-0.8	1.4
Qualifications: nursing, teaching	1.3	2.1	3.3	-1.3	-1.5	-1.0	1.8
Commuting to job workplace: Walk	0.1	0.1	0.2	0.3	0.2	0.4	-0.2
Eye problems/disorders: Cataract	0.4	0.5	0.7	-0.8	-0.7	-0.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	0.0	0.2	-0.3	-0.1
Medication for cholesterol	0.1	0.2	0.4	0.1	-0.2	0.7	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	0.2	0.3	0.2	0.1
Back pain experienced in last month	0.5	0.7	0.9	0.9	0.8	0.8	-0.7
Mineral and other dietary supplements	0.1	0.1	0.2	0.3	0.3	-0.1	-0.4
Breast cancer (self-reported)	0.3	0.3	0.7	0.8	0.5	0.4	-0.3
Asthma (self-reported)	0.1	0.1	0.5	0.7	0.2	0.2	0.2
Osteoporosis (self-reported)	2.7	3.4	3.6	1.9	1.9	1.8	-1.7
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.0	-0.2	0.0	0.2
Medication: Aspirin	0.6	0.8	1.7	-0.9	-0.8	-1.3	0.4
Medication: Gliclazide	0.2	0.2	0.5	-0.7	-0.2	-0.5	-0.5
Illnesses of father: None of the above (group 1)	0.3	0.3	0.6	0.8	0.4	0.7	-0.4
Smoking status: Current	0.2	0.3	0.6	0.2	0.7	0.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.8	-0.3	-0.4	-0.9	0.4
Whole body water mass	0.0	0.0	0.0	0.0	-0.1	0.0	-0.2
Leg predicted mass (right)	0.0	0.1	0.1	0.2	0.1	0.2	-0.3
Arm fat mass (left)	0.1	0.6	1.3	0.6	0.8	0.0	-1.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.2	0.4	0.5	0.2	-0.4
Average weekly champagne plus white wine intake	0.3	0.4	0.7	-0.9	-0.5	-0.7	0.4
Miserableness	0.2	0.4	0.6	0.8	0.5	0.6	-0.5
Guilty feelings	1.5	2.2	3.8	-1.4	-1.7	-0.5	1.9
Wears glasses or contact lenses	0.1	0.1	0.3	0.4	0.3	-0.1	-0.5
Ever taken oral contraceptive pill	3.2	3.6	3.9	1.9	1.9	2.0	-1.8
Hearing aid user	1.8	2.1	2.6	1.4	1.5	1.6	-1.2
Mother’s age at death	0.2	0.3	0.5	0.6	0.5	0.7	-0.1
Financial situation satisfaction	1.3	1.6	2.2	-1.5	-1.4	-0.9	1.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.9	-0.7	-1.0	-0.6	0.9
Commuting to job workplace: Public transport	0.4	0.4	0.9	-0.9	-0.8	-0.0	0.5
Eye problems/disorders: Glaucoma	2.9	3.5	4.8	-2.2	-1.7	-1.7	1.8
Medication: Blood pressure	0.4	0.8	1.9	-0.8	-0.7	-1.4	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.0	-0.4	-0.3	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.3
High cholesterol (Self-reported)	0.5	0.9	2.3	-0.7	-0.8	-1.5	0.4
Medication: Bendroflumethiazide	0.1	0.1	0.4	0.0	-0.3	-0.6	0.1
Medication: Paracetamol	0.0	0.0	0.0	-0.1	0.2	0.1	-0.2
Medication: Lisinopril	0.8	1.1	1.4	1.0	1.1	0.8	-1.2
Medication: Atorvastatin	0.5	0.6	1.1	-1.0	-0.9	-0.3	0.8
Illnesses of father: High blood pressure	0.3	0.3	0.5	-0.6	-0.4	-0.7	0.5
Alcohol drinker status: Never	0.0	0.0	0.1	0.2	-0.0	0.3	0.1
Ever smoked	0.1	0.1	0.3	-0.0	0.3	-0.0	-0.5
Basal metabolic rate	0.0	0.0	0.1	0.1	0.1	0.1	-0.3
Leg fat percentage (left)	0.0	0.1	0.3	0.1	0.1	-0.5	-0.5
Arm fat-free mass (left)	0.0	0.0	0.0	-0.1	-0.2	-0.2	-0.1
Number of operations (self-reported)	0.7	1.0	1.6	0.5	1.3	0.9	-1.2
Average weekly beer plus cider intake	0.3	0.4	0.6	-0.8	-0.3	-0.7	0.5
Irritability	0.4	0.6	1.1	-0.6	-1.0	-0.5	1.1
Risk taking	1.3	1.9	2.5	-1.1	-1.3	-1.5	1.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.2	0.8	1.0	0.7	-1.1
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.3	0.3	-0.3	-0.5
Age started oral contraceptive pill	1.7	2.1	2.8	-1.1	-1.4	-1.7	1.6
Diastolic blood pressure, automated reading	0.1	0.4	1.0	-0.4	-0.5	-1.0	0.4
Ever depressed for a whole week	2.0	2.5	3.3	1.3	1.7	1.8	-1.5
Unable to work because of sickness or disability	0.5	0.6	0.9	0.9	0.7	0.5	-1.0
Commuting to job workplace: Cycle	0.4	0.5	0.8	-0.5	-0.9	-0.5	0.7
Myopia	0.1	0.1	0.4	0.1	-0.4	0.1	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.3	1.1	1.1	1.5	-0.8
Cholesterol lowering medication	1.2	1.8	2.9	-1.4	-1.2	-1.7	0.9
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.6	1.1	0.9	1.3	-0.5
Pain experienced in last month	0.9	1.4	1.5	-1.2	-1.2	-1.2	1.1
Supplements: Calcium	0.1	0.1	0.1	-0.3	-0.2	0.2	0.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.0	1.0	0.8	1.0	-0.3
Heart attack/myocardial infarction (self-reported)	2.2	2.8	3.6	-1.9	-1.7	-1.2	1.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	0.9	1.0	0.7	0.7	-0.9
Heart disease (siblings)	0.0	0.0	0.2	-0.1	0.0	-0.4	-0.0
Alcohol drinker status: Previous	1.3	1.5	1.9	1.4	1.2	0.9	-1.4
Pack years of smoking	1.0	1.4	1.7	-1.3	-1.3	-1.2	1.0
Impedance of whole body	0.2	0.9	1.6	-1.0	-1.0	-0.3	1.3
Leg fat mass (left)	0.1	0.2	0.5	0.3	0.4	-0.2	-0.7
Arm predicted mass (left)	0.0	0.0	0.0	0.0	-0.2	-0.0	-0.1