TWAS hub - COX8A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0610	0.0300	2.0e-03	0.000	0.021	0.006	0.023	0.004	3.4e-01	1.3e-03	5.7e-02	8.0e-04	1.0e-01
2	YFS	Blood	0.0231	0.0079	3.7e-07	0.039	0.017	0.038	0.029	0.037	9.9e-13	1.4e-06	2.1e-12	7.9e-10	2.7e-12
3	TCGA	Breast Invasive Carcinoma	0.0120	0.0085	1.9e-03	0.013	0.007	0.011	NA	0.009	8.0e-04	1.3e-02	2.4e-03	NA	5.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Cholesterol lowering medication	8.5	12.4	30.2	-5.5	-1.8	-2.0
Alcohol drinker status: Never	7.1	8.5	12.4	1.3	3.5	3.4
Basal cell carcinoma (self-reported)	7.0	8.4	9.3	3.0	2.7	2.9
Birth weight of first child	6.8	12.3	15.5	-2.8	-3.7	-3.9
Major Depression (MDD)	6.4	7.8	12.0	-3.5	-2.6	-2.1
Average weekly beer plus cider intake	6.4	9.2	11.9	2.4	3.1	3.5
Medication: Simvastatin	6.3	9.3	23.1	-4.8	-1.2	-1.8
Other serious medical condition/disability diagnosed by doctor	6.0	7.8	8.4	-2.8	-2.7	-2.9
Ever depressed for a whole week	5.8	7.2	8.2	-2.4	-2.9	-2.8
Pulse wave reflection index	5.5	6.8	8.8	2.3	2.5	3.0
Bipolar Disorder or Schizophrenia	5.4	13.1	22.6	0.1	-4.8	-4.1
Illness, injury, bereavement, stress in last 2 years	5.3	6.4	7.5	-2.3	-2.7	-2.5
Gout (self-reported)	5.1	7.0	8.2	-2.6	-2.9	-2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	4.8	7.3	9.6	-2.3	-3.1	-2.7
Birth weight	4.8	10.4	12.7	-2.8	-3.6	-3.2
Bipolar Disorder (2018)	4.5	7.1	10.9	-0.0	-3.2	-3.3
High cholesterol (Self-reported)	4.5	8.0	16.8	-4.1	-1.6	-2.1
Mouth/teeth dental problems: Loose teeth	4.3	5.1	5.9	2.2	2.1	2.4
Crohns Disease (2017)	4.1	9.1	10.9	-3.3	-2.9	-2.8
Number of live births	4.1	5.7	12.7	-3.6	-1.7	-1.3
Number of children fathered	3.9	4.4	6.5	-1.7	-1.9	-2.5
Medication: Aspirin	3.9	5.2	10.2	-3.2	-1.4	-1.8
Handedness (chirality/laterality): Left-handed	3.8	4.6	5.7	2.2	1.8	2.4
Wears glasses or contact lenses	3.5	4.1	8.4	-2.9	-1.6	-1.1
Had major operations	3.4	3.9	5.1	-2.3	-1.3	-2.3
Financial situation satisfaction	3.3	4.0	5.2	1.9	1.8	2.3
Number of full sisters	3.2	3.9	6.7	-2.6	-1.7	-1.4
Illnesses of siblings: Diabetes	3.2	3.9	6.2	-0.9	-2.5	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.2	6.8	8.9	-1.7	-3.0	-2.9
Heart disease (siblings)	3.2	3.9	6.5	-2.5	-1.3	-1.9
Schizophrenia (2018)	3.1	6.4	12.3	0.0	-3.5	-2.6
Heart disease (mother)	2.8	3.4	8.1	-2.8	-1.1	-1.0
Schizophrenia (2014)	2.7	6.0	12.4	0.8	-3.5	-2.2
Migraine (self-reported)	2.7	3.4	8.8	3.0	-1.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.3	6.1	-2.5	-1.5	-1.2
Multivitamins +/- minerals	2.6	3.3	4.5	-2.1	-1.5	-1.8
Medication: Metformin	2.5	3.6	9.2	-3.0	-0.6	-1.0
Medication: Aspirin	2.5	3.3	6.4	-2.5	-1.2	-1.5
Alzheimer’s Disease (including proxy)	2.4	3.5	5.2	-1.7	-1.6	-2.3
Systolic Blood Pressure	2.4	12.0	18.8	1.6	4.3	3.8
Lung FEV1/FVC ratio	2.4	12.4	16.7	-4.1	-3.4	-3.0
Illnesses of mother	2.4	3.0	7.0	2.6	1.2	0.7
Chronic bronchitis/emphysema (mother)	2.4	2.8	4.3	-2.1	-1.6	-1.2
Medication: Allopurinol	2.4	3.2	5.3	-2.3	-1.8	-1.0
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	4.6	-1.8	-1.9	-2.1
Medication: Lansoprazole	2.3	2.7	3.6	-1.9	-1.5	-1.4
Exposure to tobacco smoke at home	2.3	2.6	5.3	0.5	1.5	2.3
Eye problems/disorders: Cataract	2.3	2.6	5.1	-0.3	-1.6	-2.3
Crohns Disease (2012)	2.2	3.6	7.9	-2.8	-1.0	-1.3
Lung FVC	2.2	11.3	14.7	-2.7	-3.4	-3.8
Depression (self-reported)	2.2	2.7	3.6	-1.3	-1.7	-1.9
Medication: Atorvastatin	2.2	2.7	7.5	-2.7	-0.1	-0.8
Bipolar Disorder (2011)	2.1	2.0	2.5	1.2	-1.4	-1.6
Had menopause	2.1	2.6	3.3	-1.4	-1.8	-1.6
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	6.3	-2.5	-1.7	-1.0
Myopia	2.1	3.1	4.4	1.3	2.1	1.7
Systolic blood pressure, automated reading	2.0	5.8	9.4	-0.2	3.1	2.8
Fed-up feelings	2.0	3.6	7.6	0.3	1.8	2.8
Alcohol usually taken with meals	2.0	3.3	4.7	-0.8	-2.1	-2.2
Loneliness, isolation	2.0	2.7	5.2	1.2	1.2	2.3
Diabetes (mother)	1.9	2.4	3.0	-1.1	-1.7	-1.7
Taking other prescription medications	1.9	3.0	7.5	-2.7	-0.5	-1.1
Breastfed as a baby	1.9	2.4	4.8	-0.2	-1.5	-2.2
Peak expiratory flow (PEF)	1.9	4.5	5.1	-2.0	-2.2	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	3.8	0.0	1.5	1.9
Medication: Blood pressure	1.9	3.6	6.5	0.1	2.1	2.6
Neuroticism	1.8	4.3	5.3	2.3	1.7	2.2
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	2.6	-1.3	-1.6	-1.6
Medication: Cholesterol lowering	1.8	2.8	6.1	-2.5	-0.6	-1.4
Hypertension (Self-reported)	1.8	5.1	6.4	-1.7	2.5	2.5
Irritable Bowel Disease (IBD)	1.7	4.2	5.1	-1.9	-1.9	-2.3
Breast Cancer	1.7	4.1	4.9	-1.9	-2.2	-1.9
High blood pressure	1.7	4.9	5.7	-1.8	2.4	2.4
Chronic bronchitis/emphysema (father)	1.7	2.0	3.2	-1.1	-1.8	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.2	0.6	-1.8	-1.8
Eye problems/disorders: Glaucoma	1.7	2.0	4.2	-0.5	2.1	1.3
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	2.2	-1.5	-1.0	-1.4
Medication: Ramipril	1.6	2.0	3.2	-1.8	1.2	1.2
Glaucoma (self-reported)	1.6	1.9	3.7	-0.4	1.9	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	2.7	-1.6	-1.5	-0.8
Hearing difficulty/problems: Yes	1.5	2.3	3.2	1.6	1.2	1.8
Supplements: Zinc	1.5	1.6	3.2	1.8	-1.0	-0.8
Maternal smoking around birth	1.5	2.2	4.4	-0.4	1.5	2.1
Stomach or abdominal pain in last month	1.5	1.8	2.1	-1.2	-1.4	-1.4
Medication: Atenolol	1.5	1.9	5.1	-2.3	-0.4	-0.6
Time employed in main current job	1.5	1.7	2.7	0.5	1.5	1.6
Prospective memory result	1.5	1.8	2.7	-0.9	-1.6	-1.4
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	5.6	0.0	-1.2	-2.4
Number of full brothers	1.5	1.9	2.8	-1.2	-1.7	-1.2
Commuting to job workplace: Car/motor vehicle	1.5	1.7	2.5	-1.6	-1.4	-0.9
Back pain experienced in last month	1.5	2.2	3.3	-0.4	1.8	1.8
Vascular/heart problems diagnosed by doctor	1.5	4.1	6.5	2.5	-1.7	-1.7
Worry (Nagel 2018)	1.4	2.9	5.0	2.2	1.4	1.4
HDL Cholesterol	1.4	2.3	6.4	-2.5	-0.1	-0.6
Number of treatments/medications taken	1.4	2.5	7.5	-2.7	0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.0	1.7	0.6	1.2
Mouth/teeth dental problems: Dentures	1.4	2.4	6.4	-2.5	0.7	0.5
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	6.3	2.5	-0.7	-0.1
Qualifications: College or University degree	1.4	4.5	8.2	-0.5	-2.3	-2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.7	-2.2	-0.2	-0.3
Irritability	1.4	2.3	3.6	0.2	1.8	1.9
Blood Platelet Count	1.3	15.3	35.0	-5.9	-2.0	-2.6
Vitamin and mineral supplements	1.3	1.8	3.0	1.7	1.1	1.0
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	6.9	-0.3	-2.6	-2.5
Loud music exposure frequency	1.3	1.4	1.8	1.2	1.0	1.3
Blood clot in the leg (DVT)	1.3	1.7	3.2	0.0	1.8	1.4
Medication for cholesterol	1.3	2.0	5.8	2.4	0.2	-0.3
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.6	-1.6	-1.0	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	2.9	0.1	1.7	1.4
Primary Biliary Cirrhosis	1.2	1.7	4.9	-2.2	0.1	-0.4
Blood White Count	1.2	8.6	12.7	-3.6	-2.6	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	5.7	0.2	-2.4	-1.7
Pain all over the body in last month	1.2	1.3	1.7	-1.3	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	6.0	-0.7	-2.2	-2.4
High blood pressure (siblings)	1.2	1.7	3.2	0.3	1.8	1.3
Health satisfaction	1.2	1.6	3.6	-1.9	-1.1	-0.2
Illnesses of father: High blood pressure	1.2	1.4	1.7	1.3	1.0	1.3
Alzheimer’s Disease (in mother)	1.1	1.3	1.4	-1.2	-1.1	-1.2
Triglycerides	1.1	1.9	2.5	1.4	1.1	1.6
Relative age of first facial hair	1.1	2.2	5.8	-2.4	-0.4	-0.8
Mouth/teeth dental problems	1.1	1.7	4.7	2.2	-0.5	-0.5
Medication: Blood pressure	1.1	2.0	2.6	-1.6	1.5	1.0
Overall health rating	1.1	2.3	4.4	-1.1	1.1	2.1
Chest pain or discomfort	1.1	1.6	2.7	-1.6	1.1	0.9
Neuroticism (Nagel 2018)	1.0	2.4	3.1	1.6	1.3	1.8
LDL Cholesterol	1.0	1.5	2.8	-1.7	-0.8	-1.1
Heel T-Score	1.0	7.8	9.5	-2.6	-3.1	-2.7
Average weekly spirits intake	1.0	1.2	1.4	-1.2	-1.0	-1.1
Relative age voice broke	1.0	1.6	4.5	-2.1	0.0	-0.6
Age at first live birth	1.0	1.8	3.5	1.9	1.3	0.3
Emphysema/chronic bronchitis	1.0	1.1	2.1	1.5	0.2	1.1
Mean time to correctly identify matches	1.0	1.8	2.7	0.8	-1.5	-1.6
Knee pain experienced in last month	1.0	1.6	3.0	-0.1	1.3	1.7
Osteoporosis (self-reported)	1.0	1.2	2.6	-1.6	-0.4	-0.9
Reaction Time	0.9	1.8	2.9	1.7	-1.1	-1.1
Medication for hormone replacement therapy	0.9	1.0	2.2	-1.5	-0.9	-0.2
Hand grip strength (right)	0.9	2.4	3.5	-0.7	-1.9	-1.8
Townsend deprivation index at recruitment	0.9	1.3	1.7	-0.8	1.3	1.2
Forced vital capacity (FVC)	0.9	3.4	5.3	0.9	-2.0	-2.3
Standing height	0.9	8.6	9.5	2.9	3.1	2.8
Pulse rate, automated reading	0.9	2.8	5.7	-2.4	-1.4	-0.8
Alcohol intake frequency.	0.9	2.1	6.2	-2.5	-0.4	-0.3
Commuting to job workplace: Cycle	0.9	1.1	2.7	1.6	0.7	-0.5
Depressed Affect (Nagel 2018)	0.8	1.6	2.7	1.2	0.8	1.6
Age at First Birth	0.8	1.1	2.3	1.5	1.0	0.2
Type 2 Diabetes (T2D) (2012)	0.8	1.0	1.3	1.1	1.1	0.5
BMI	0.8	4.6	7.3	-2.1	1.5	2.7
Cardiovascular Disease	0.8	2.5	4.9	-2.2	1.1	1.2
Body mass index (BMI)	0.8	3.3	9.1	-3.0	-0.4	0.8
Hearing difficulty/problems with background noise	0.8	1.3	2.0	-0.1	-1.4	-1.4
Heart attack	0.8	1.0	1.3	-1.2	-0.9	-1.0
Arm fat percentage (right)	0.8	3.3	8.6	-2.9	-0.2	1.1
Trunk fat-free mass	0.8	4.8	8.0	0.8	2.4	2.8
Father’s age at death	0.8	1.1	2.0	0.2	-1.4	-1.1
Trunk predicted mass	0.8	4.6	7.8	0.7	2.4	2.8
Exposure to tobacco smoke outside home	0.8	1.1	1.4	-1.2	1.0	1.0
Arm fat percentage (left)	0.8	3.0	7.6	-2.8	-0.2	1.2
Hearing aid user	0.8	0.9	1.4	-0.7	1.2	0.9
Medication: Bendroflumethiazide	0.8	1.3	1.8	-0.9	1.3	1.1
Body Mass Index (BMI) (2010)	0.7	1.0	1.3	-1.2	0.8	1.0
Coronary Artery Disease (CAD)	0.7	0.9	1.1	-0.8	-1.1	-0.9
Height	0.7	12.9	17.2	2.9	4.2	3.6
Hand grip strength (left)	0.7	1.9	2.4	-1.1	-1.4	-1.5
Ever had hysterectomy (womb removed)	0.7	0.7	1.7	1.3	0.4	0.6
Diabetes (father)	0.7	0.9	1.4	0.4	1.2	1.0
Average weekly fortified wine intake	0.7	0.9	2.0	0.7	-1.4	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.9	0.1	0.9	1.4
Trunk fat mass	0.7	2.8	4.0	-1.9	0.8	2.0
Number of incorrect matches in round	0.7	1.1	1.5	1.2	-1.0	-0.9
Nervous feelings	0.7	1.3	1.6	0.9	1.2	1.3
Qualifications: None of the above	0.7	1.5	3.1	-0.8	1.0	1.8
Financial difficulties in last 2 years	0.7	0.9	1.2	0.8	1.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	0.5	1.0	1.2
Arm fat mass (right)	0.7	3.0	7.0	-2.6	0.2	1.4
Forced vital capacity (FVC), Best measure	0.7	2.4	4.7	0.1	-1.6	-2.2
Shortness of breath walking on level ground	0.7	0.8	1.0	-1.0	-1.0	-0.8
Neck or shoulder pain in last month	0.7	1.0	2.1	-1.4	-0.7	-0.7
Leg fat mass (right)	0.7	2.7	4.5	-1.7	0.9	2.1
Arm predicted mass (right)	0.7	3.6	6.6	0.5	2.0	2.6
Comparative height size at age 10	0.7	4.1	7.7	2.8	1.4	1.6
Whole body fat-free mass	0.7	3.8	7.2	0.3	2.0	2.7
Long-standing illness, disability or infirmity	0.7	1.0	2.9	-1.7	0.4	0.2
Arm fat mass (left)	0.7	2.9	6.1	-2.5	0.3	1.6
Medication: Paracetamol	0.7	1.1	1.3	1.1	1.1	0.9
Basal metabolic rate	0.7	3.6	7.3	-0.1	1.9	2.7
Leg fat percentage (left)	0.7	2.4	6.5	-2.5	-0.5	0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.8	-1.4	-0.8	-0.5
Pain experienced in last month	0.7	1.1	2.3	0.4	-1.0	-1.5
Heart attack/myocardial infarction (self-reported)	0.7	0.8	1.0	-1.0	-0.9	-0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.4	1.7	-1.2	-1.0	-1.3
Ovarian Cancer	0.6	0.8	1.7	-1.3	-0.6	-0.7
Sensitivity / hurt feelings	0.6	1.0	1.2	-1.1	-1.1	-0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.3	-1.5	-0.3	0.2
Angina	0.6	0.8	1.9	-1.4	0.6	0.1
Trunk fat percentage	0.6	2.5	5.8	-2.4	0.1	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.0	0.3	-1.7	-1.1
Serious illness, injury or assault to yourself	0.6	0.7	0.9	0.9	0.7	1.0
Medication: Levothyroxine sodium	0.6	1.0	1.2	-1.1	1.0	0.8
Sitting height	0.6	4.3	6.1	1.7	2.5	2.0
Worrier / anxious feelings	0.6	1.2	2.0	-0.0	-1.4	-1.3
Qualifications: A levels/AS levels or equivalent	0.6	1.2	2.3	0.6	-1.0	-1.5
Body fat percentage	0.6	2.6	6.0	-2.4	0.1	1.3
Leg fat percentage (right)	0.6	2.1	5.1	-2.2	0.1	1.1
Arm fat-free mass (right)	0.6	3.2	6.0	0.5	1.8	2.5
Medication: Omeprazole	0.6	0.7	1.4	-1.2	-0.7	-0.5
Whole body fat mass	0.6	2.4	3.6	-1.8	0.7	1.9
Supplements: Vitamin C	0.6	0.7	1.2	-1.1	-0.7	-0.5
Average weekly red wine intake	0.6	0.8	1.4	0.4	-1.0	-1.2
Diabetes diagnosed by doctor	0.6	1.0	2.5	-1.6	-0.4	-0.6
Whole body water mass	0.6	3.6	6.8	0.2	2.0	2.6
Commuting to job workplace: Public transport	0.6	0.7	1.4	1.2	0.7	0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.6	-1.3	0.6	0.5
Leg fat mass (left)	0.6	2.4	3.5	-1.9	0.6	1.9
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.5	-1.6	-0.7	-1.3
Medication: Co-codamol	0.5	0.6	1.3	-1.1	-0.6	-0.2
Severe depression (siblings)	0.5	0.5	1.5	1.2	-0.1	0.2
Impedance of leg (right)	0.5	2.6	6.3	2.5	0.9	0.7
Leg fat-free mass (left)	0.5	2.7	5.6	-0.4	1.5	2.4
Age when periods started (menarche)	0.5	1.3	3.8	-1.9	-0.3	-0.4
Leg predicted mass (left)	0.5	2.9	6.0	-0.4	1.6	2.4
Waist circumference	0.5	1.9	4.1	-2.0	0.2	1.2
Fluid intelligence score	0.5	1.0	1.6	-0.3	-1.3	-1.2
Weight	0.5	2.5	4.1	-1.6	1.0	2.0
Tense / ‘highly strung’	0.5	0.9	1.3	0.0	-1.1	-1.2
Angina (self-reported)	0.5	0.7	2.0	-1.4	0.4	-0.2
Medication: Ibuprofen	0.5	0.5	0.7	0.8	0.7	0.7
Mood swings	0.5	0.9	2.3	0.4	0.6	1.5
Number of self-reported non-cancer illnesses	0.5	0.8	2.4	-1.6	-0.3	-0.1
Guilty feelings	0.5	0.8	1.2	-0.3	-1.1	-1.1
Mother’s age at death	0.5	0.7	1.4	-0.7	-0.4	-1.2
Arm fat-free mass (left)	0.5	2.5	5.0	-0.2	1.5	2.2
Diastolic blood pressure, automated reading	0.5	1.4	2.9	-0.0	1.2	1.7
Arm predicted mass (left)	0.5	2.5	5.2	-0.1	1.6	2.3
Chronotype (morning person)	0.4	0.9	2.4	1.6	-0.5	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.0	-0.1	-1.0	-0.8
Hair/balding pattern: Pattern 2	0.4	0.5	0.8	-0.9	-0.5	-0.8
Diabetes (self-reported)	0.4	0.6	1.5	-1.2	0.4	0.1
Neuroticism score	0.4	0.8	1.5	1.2	0.3	1.0
Hip circumference	0.4	1.8	3.6	-1.0	0.9	1.9
Pulse rate	0.4	0.7	1.1	-1.1	-0.8	-0.5
Happiness	0.4	0.5	1.3	-1.1	-0.3	-0.2
Length of working week for main job	0.4	0.4	0.6	-0.6	0.8	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.1	-1.5	0.3	-0.1
Medication: Amlodipine	0.4	0.6	0.8	-0.5	0.9	0.8
Medication for pain relief, constipation, heartburn	0.4	0.8	2.3	1.5	0.1	0.0
Family relationship satisfaction	0.4	0.5	1.0	0.0	-1.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.0	1.4	-0.4	-0.3
Ever had bowel cancer screening	0.4	0.5	1.4	-1.2	0.1	0.1
Ever taken oral contraceptive pill	0.4	0.5	0.8	-0.5	-0.9	-0.6
Number of operations (self-reported)	0.4	0.6	1.3	-1.2	-0.2	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-0.8	-0.0	-0.9
Pack years adult smoking proportion	0.3	0.5	0.7	-0.9	-0.9	-0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	0.1	0.7	0.8
High blood pressure (mother)	0.3	0.4	0.6	-0.7	0.3	0.8
Impedance of leg (left)	0.3	1.6	4.8	2.2	0.2	-0.0
Had other major operations	0.3	0.4	0.7	-0.3	0.6	0.8
Illnesses of siblings	0.3	0.4	0.7	0.9	0.3	0.5
Falls in the last year	0.3	0.4	0.6	-0.1	0.7	0.8
Asthma	0.3	0.6	0.9	-0.5	-0.9	-0.7
Medication: Paracetamol	0.3	0.5	0.7	0.6	0.8	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	-0.5	-0.8	-0.6
Comparative body size at age 10	0.3	0.9	1.3	1.1	0.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.4	-0.5	-0.5	-0.7
Suffer from ‘nerves’	0.3	0.5	1.0	-0.1	0.7	1.0
Age at last live birth	0.3	0.4	1.0	-0.3	1.0	0.4
Illnesses of father: Heart disease	0.3	0.5	1.0	-0.4	-1.0	-0.5
Leg fat-free mass (right)	0.3	1.5	3.3	-0.5	1.0	1.8
Friendships satisfaction	0.3	0.4	0.7	0.8	-0.5	0.4
Qualifications: nursing, teaching	0.3	0.4	0.7	0.8	0.4	-0.6
Leg predicted mass (right)	0.3	1.6	3.5	-0.6	1.1	1.9
Miserableness	0.3	0.5	0.9	0.3	0.8	0.9
Medication: Lisinopril	0.3	0.4	0.5	-0.7	-0.5	-0.7
Risk taking	0.3	0.4	1.2	1.1	0.2	0.1
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.6	0.9	0.4
Supplements: Calcium	0.3	0.3	1.0	-0.0	-0.0	-1.0
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.2	0.7	0.3
HbA1C	0.2	0.2	0.2	0.5	-0.5	-0.4
Neuroticism (2016)	0.2	0.3	0.5	-0.7	0.0	-0.7
Blood Eosinophil Count	0.2	1.8	3.2	0.6	-1.8	-1.4
Waist Hip Ratio (WHR)	0.2	0.9	1.2	-1.0	-1.1	-0.8
Smoking Status	0.2	0.4	0.6	-0.7	-0.3	0.8
Hypothyroidism (self reported)	0.2	0.5	1.1	-1.0	-0.3	-0.4
Respiratory disease	0.2	0.4	1.0	0.1	-1.0	-0.3
Qualifications: CSEs or equivalent	0.2	0.2	0.5	0.7	-0.3	0.1
Hair/balding pattern: Pattern 3	0.2	0.2	0.6	0.2	0.8	0.3
Noisy workplace	0.2	0.3	0.4	-0.3	0.6	0.7
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	-1.1	0.3	0.2
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.3	-0.4	-0.7
Worry too long after embarrassment	0.2	0.3	0.7	0.4	-0.8	-0.3
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.2	0.4	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.7	0.1	0.3
Smoking status: Previous	0.2	0.3	0.5	-0.1	-0.7	-0.7
Mineral and other dietary supplements	0.2	0.3	0.6	-0.8	-0.1	0.6
Osteoarthritis (self-reported)	0.2	0.2	0.5	-0.4	0.7	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.7	0.1	-0.5
Age started oral contraceptive pill	0.2	0.3	0.8	-0.9	0.1	0.0
Unable to work because of sickness or disability	0.2	0.3	0.4	-0.5	0.4	0.6
Depression (Nagel 2018)	0.1	0.1	0.2	0.4	-0.5	-0.2
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.3	-0.2	-0.7
Prostate Cancer	0.1	0.2	0.4	0.1	0.6	0.4
Mean Putamen Volume	0.1	0.1	0.4	0.6	-0.1	0.1
Ulcerative Colitis	0.1	0.1	0.2	-0.1	0.4	-0.5
Allergy or Eczema	0.1	0.3	0.5	-0.3	-0.6	-0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.8	0.2	0.1
Hair Pigment	0.1	3.2	4.8	-1.9	2.2	1.0
Tanning	0.1	1.5	2.8	1.7	-1.1	-0.7
Current tobacco smoking	0.1	0.2	0.5	-0.4	0.0	0.7
Supplements: Glucosamine	0.1	0.1	0.2	0.2	0.4	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	0.6	0.4	0.2
Past tobacco smoking	0.1	0.1	0.3	0.0	0.5	0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	-0.6	-0.2	-0.2
Lung cancer (father)	0.1	0.1	0.2	-0.3	-0.1	0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.2	0.0	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	0.6	0.2	0.4
Pulse wave peak to peak time	0.1	0.1	0.2	0.5	0.3	-0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.3	-0.5	-0.1
Leg pain on walking	0.1	0.2	0.4	-0.2	-0.7	0.1
Commuting to job workplace: Walk	0.1	0.2	0.3	0.3	-0.5	-0.3
Asthma (self-reported)	0.1	0.2	0.4	-0.1	-0.6	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.5	0.2	0.1
Smoking status: Current	0.1	0.1	0.1	-0.4	-0.3	0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.2	0.4	0.4	-0.1
Ever smoked	0.1	0.2	0.4	0.7	-0.2	0.1
Alcohol drinker status: Previous	0.1	0.2	0.5	-0.1	-0.1	-0.7
Pack years of smoking	0.1	0.2	0.4	-0.6	-0.5	0.2
Impedance of whole body	0.1	0.5	1.3	1.1	0.0	-0.3
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	-0.4	-0.0	0.2
Fasting Glucose	0.0	0.1	0.1	0.2	0.2	0.2
Lupus	0.0	0.0	0.0	0.1	0.2	-0.1
Rheumatoid Arthritis	0.0	0.0	0.1	-0.1	0.3	-0.1
Blood Red Count	0.0	0.1	0.4	0.6	-0.0	-0.1
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.2	0.2	0.1
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.0	0.2	-0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.1	-0.2	-0.3
Allergy	0.0	0.0	0.1	-0.3	0.2	-0.0
Impedance of arm (right)	0.0	0.1	0.1	0.4	-0.0	-0.2
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.1	0.1	-0.2
Impedance of arm (left)	0.0	0.1	0.4	0.6	0.2	-0.1
Headache pain in last month	0.0	0.1	0.1	0.3	-0.2	0.2
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	-0.2	0.0	0.1
Breast cancer (self-reported)	0.0	0.0	0.1	-0.1	-0.2	-0.2
Medication: Gliclazide	0.0	0.0	0.0	-0.2	-0.1	0.1

Hub : Genes

COX8A

Models

Trait associations