Hub : Genes

CPEB3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.129 0.0376 1.5e-09 0.180 NA 0.173 NA 0.182 8.7e-13 NA 2.8e-12 NA 6.8e-13
2 GTEx Whole Blood 0.043 0.0210 2.9e-03 0.008 NA 0.013 NA 0.016 5.3e-02 NA 1.9e-02 NA 1.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.1 0.2 0.1 -0.5
Bipolar Disorder or Schizophrenia 0.2 0.5 0.8 -0.9 0.3
Depressed Affect (Nagel 2018) 0.6 1.3 2.0 -0.7 1.4
Depression (Nagel 2018) 0.0 0.0 0.1 -0.2 0.2
Intelligence (Savage-Jansen 2018) 5.4 16.7 22.4 3.3 -4.7
Neuroticism (Nagel 2018) 1.8 4.3 5.0 -1.9 2.2
Schizophrenia (2018) 0.5 1.1 1.7 -1.3 0.7
Schizophrenia vs Biploar Disorder 0.9 1.2 1.4 1.2 -1.0
Worry (Nagel 2018) 2.0 4.3 5.0 -1.9 2.2
Alzheimer’s Disease (in mother) 1.1 1.3 2.4 0.4 -1.6
Alzheimer’s Disease (in father) 0.5 0.5 0.9 1.0 -0.3
Alzheimer’s Disease (including proxy) 1.6 2.4 2.9 1.4 -1.7
Crohns Disease (2017) 0.5 1.0 1.1 -1.0 1.0
Irritable Bowel Disease (IBD) 4.2 10.0 11.1 -3.3 3.0
Ulcerative Colitis (UC) 6.6 12.4 12.6 -3.5 3.5
Major Depression (MDD) 1.7 2.1 3.6 -0.8 1.9
Reaction Time 3.4 6.4 6.6 2.5 -2.6
Verbal and Numeric Reasoning (VNR) 5.6 13.5 18.3 2.9 -4.3
Breast Cancer 5.7 13.8 15.0 -3.9 3.6
Ovarian Cancer 1.4 1.8 2.9 -0.8 1.7
Prostate Cancer 1.4 2.0 3.0 -1.0 1.7
Age at First Birth 0.7 1.0 1.5 0.8 -1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 -0.2 -0.1
Body Mass Index (BMI) (2010) 1.7 2.3 2.6 -1.6 1.4
Coronary Artery Disease (CAD) 3.5 4.2 6.4 -2.5 1.4
Crohns Disease (2012) 0.6 1.0 1.6 -1.2 0.6
Mean Putamen Volume 0.3 0.4 0.5 -0.5 0.7
Fasting Glucose 0.3 0.4 0.7 0.8 -0.4
HbA1C 0.1 0.1 0.2 -0.5 -0.2
HDL Cholesterol 0.1 0.1 0.3 -0.1 0.5
LDL Cholesterol 0.1 0.1 0.1 0.3 0.4
Lupus 0.1 0.2 0.2 -0.4 0.5
Neuroticism (2016) 0.5 0.7 1.4 0.1 1.2
Primary Biliary Cirrhosis 0.2 0.2 0.4 0.1 -0.7
Rheumatoid Arthritis 0.5 0.7 1.0 1.0 -0.7
Schizophrenia (2014) 0.1 0.1 0.2 0.3 -0.5
Triglycerides 0.5 0.8 1.5 -1.2 -0.1
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.5 -0.7 0.0
Ulcerative Colitis 4.4 6.4 7.8 -2.8 2.2
Blood Eosinophil Count 0.0 0.1 0.2 -0.4 0.3
Blood Platelet Count 2.0 22.7 25.1 5.0 -4.5
Blood Red Count 0.4 3.5 3.8 1.8 -2.0
Blood White Count 0.1 1.1 1.3 0.9 1.1
Heel T-Score 0.1 0.6 0.9 -1.0 0.6
BMI 2.7 15.6 21.4 -3.1 4.6
Height 1.8 35.0 54.8 3.9 -7.4
Waist Hip Ratio (WHR) 1.8 8.2 8.8 -2.8 3.0
Systolic Blood Pressure 0.2 0.9 1.4 0.6 -1.2
Smoking Status 0.8 1.8 3.5 -0.4 1.9
Allergy or Eczema 0.3 0.7 1.4 0.2 -1.2
Cardiovascular Disease 0.0 0.0 0.1 -0.1 -0.3
Hypothyroidism (self reported) 1.7 3.9 5.4 -1.5 2.3
Respiratory disease 0.5 1.2 1.3 -1.1 1.1
Type 2 Diabetes (T2D) (2018) 1.9 3.6 4.6 -2.1 1.6
Lung FEV1/FVC ratio 0.0 0.2 0.3 -0.6 -0.2
Lung FVC 0.4 2.2 2.9 1.7 -1.2
Neuroticism 1.3 3.1 4.3 -1.4 2.1
Chronotype (morning person) 6.3 14.5 14.5 -3.8 3.8
Hair Pigment 0.1 1.4 2.0 -0.9 1.4
Tanning 0.1 0.6 0.9 0.6 -0.9
Hand grip strength (left) 1.1 2.8 4.0 1.2 -2.0
Number of treatments/medications taken 0.7 1.3 1.5 -1.1 1.2
Average weekly spirits intake 1.3 1.6 3.0 -1.7 0.2
Sensitivity / hurt feelings 0.4 0.8 0.8 -0.9 0.8
Frequency of depressed mood in last 2 weeks 0.9 1.2 1.3 -1.1 1.1
Hearing difficulty/problems: Yes 0.2 0.3 0.6 0.8 -0.0
Relative age of first facial hair 2.5 5.2 6.6 2.0 -2.6
Other serious medical condition/disability diagnosed by doctor 1.5 2.0 2.6 -1.6 1.2
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.0 -0.0 0.0
Ever had hysterectomy (womb removed) 0.9 1.0 1.9 -0.3 -1.4
Systolic blood pressure, automated reading 0.1 0.2 0.2 0.5 -0.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.5 -0.7 0.2
Angina 0.3 0.4 0.6 -0.4 0.8
Medication for hormone replacement therapy 0.1 0.2 0.3 -0.6 0.0
Vitamin and mineral supplements 0.1 0.1 0.1 0.2 0.4
Supplements: Zinc 0.6 0.6 0.8 -0.9 0.6
Medication: Co-codamol 3.3 3.8 5.7 -2.4 1.4
Medication: Metformin 0.1 0.2 0.3 -0.6 0.2
Diabetes (father) 2.6 3.2 3.7 -1.6 1.9
Diabetes (mother) 8.7 11.1 13.1 -3.6 3.0
Severe depression (siblings) 0.1 0.1 0.2 -0.1 0.4
Pack years adult smoking proportion 4.5 6.8 7.0 -2.6 2.7
Impedance of leg (right) 0.0 0.1 0.2 -0.2 0.4
Leg fat-free mass (left) 0.0 0.2 0.3 -0.6 -0.2
Trunk fat percentage 5.8 23.3 30.9 -4.0 5.6
Hand grip strength (right) 0.8 2.1 3.8 0.7 -2.0
Townsend deprivation index at recruitment 1.8 2.5 4.7 -0.5 2.2
Current tobacco smoking 0.1 0.1 0.2 -0.1 0.5
Average weekly fortified wine intake 2.0 2.3 3.0 -1.7 1.3
Maternal smoking around birth 2.1 3.1 5.8 -0.6 2.4
Fed-up feelings 3.7 6.7 6.8 -2.6 2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 0.8 -0.9 0.9
Relative age voice broke 0.1 0.2 0.2 -0.3 -0.5
Taking other prescription medications 0.2 0.3 0.4 -0.5 0.6
Age when periods started (menarche) 0.8 2.0 3.5 1.9 -0.7
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 3.0 0.5 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.3 0.5 -0.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 -0.9 -0.2
Qualifications: CSEs or equivalent 0.6 0.8 0.9 -1.0 0.8
Serious illness, injury or assault to yourself 1.4 1.7 2.1 -1.5 1.1
High blood pressure 0.0 0.0 0.0 -0.0 -0.2
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.3 -0.5 -0.1
Multivitamins +/- minerals 0.2 0.3 0.5 0.3 -0.7
Stomach or abdominal pain in last month 0.1 0.2 0.3 -0.5 -0.1
Supplements: Glucosamine 0.2 0.3 0.7 0.0 0.8
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.8 -0.9 -0.1
Medication: Atenolol 0.5 0.7 1.3 -1.2 0.1
Medication: Levothyroxine sodium 1.7 2.9 4.3 -1.2 2.1
Sitting height 1.5 10.5 20.5 0.7 -4.5
Chronic bronchitis/emphysema (father) 1.7 2.0 2.8 -1.1 1.7
High blood pressure (mother) 0.2 0.2 0.4 -0.7 -0.2
Body mass index (BMI) 3.1 13.2 18.6 -2.8 4.3
Impedance of leg (left) 0.0 0.0 0.1 -0.2 0.2
Leg predicted mass (left) 0.0 0.2 0.4 -0.6 -0.2
Trunk fat mass 3.1 13.4 16.6 -3.2 4.1
Waist circumference 4.7 17.2 22.0 -3.5 4.7
Number of incorrect matches in round 0.1 0.1 0.2 -0.1 0.4
Past tobacco smoking 1.7 3.2 5.6 0.9 -2.4
Alcohol usually taken with meals 0.3 0.5 0.6 -0.8 0.6
Nervous feelings 1.9 3.5 3.7 -1.8 1.9
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 1.3 -1.0 1.1
Hearing difficulty/problems with background noise 0.2 0.4 0.5 0.7 -0.5
Hair/balding pattern: Pattern 2 0.0 0.0 0.0 0.2 -0.2
Had menopause 1.0 1.3 1.3 -1.2 1.1
Had other major operations 3.9 4.7 4.9 -2.2 2.1
Forced vital capacity (FVC) 0.5 1.8 3.5 0.5 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 0.4 0.1
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.3 0.0 -0.6
Qualifications: None of the above 0.3 0.7 1.3 -0.3 1.1
Financial difficulties in last 2 years 1.2 1.6 1.7 -1.3 1.3
Mouth/teeth dental problems 1.0 1.5 1.6 1.3 -1.2
Heart attack 0.1 0.1 0.3 0.0 0.5
Allergy 0.8 1.8 2.7 1.6 -1.0
Pain all over the body in last month 0.2 0.2 0.3 -0.5 -0.4
Diabetes (self-reported) 1.1 1.7 2.6 -1.6 0.9
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.9 0.3 -1.0
Medication: Ramipril 0.2 0.2 0.4 0.6 -0.1
Medication: Simvastatin 0.1 0.1 0.2 -0.2 0.4
Fluid intelligence score 4.4 9.1 13.3 2.2 -3.6
Illnesses of siblings 0.7 0.9 1.3 0.7 -1.2
Neuroticism score 1.2 2.5 2.8 -1.5 1.7
Weight 0.8 3.9 4.2 -2.0 1.9
Impedance of arm (right) 1.4 6.6 8.5 -2.1 2.9
Arm fat percentage (right) 7.7 30.5 41.2 -4.4 6.4
Trunk fat-free mass 1.2 6.8 12.2 1.2 -3.5
Hip circumference 1.8 7.6 9.2 -2.5 3.0
Time employed in main current job 0.6 0.6 1.2 0.2 -1.1
Alcohol intake versus 10 years previously 0.4 0.6 0.7 0.8 -0.8
Father’s age at death 0.4 0.5 0.6 -0.8 0.6
Worrier / anxious feelings 0.4 0.8 1.2 -1.1 0.6
Frequency of tiredness / lethargy in last 2 weeks 2.8 4.5 6.2 -2.5 1.7
Falls in the last year 5.9 8.0 8.9 -3.0 2.6
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 0.8 -0.1
Number of live births 4.0 5.7 6.1 -2.5 2.3
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 2.4 0.1 -1.6
Pulse rate 2.8 4.8 7.0 -1.6 2.6
Happiness 0.2 0.2 0.5 -0.7 -0.1
Noisy workplace 2.1 2.6 2.6 -1.6 1.6
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.2 0.5 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.0 -1.0 0.7
Mouth/teeth dental problems: Dentures 2.5 4.3 4.9 -2.2 1.9
Asthma 0.3 0.7 1.1 -0.5 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.7 -0.9 0.4
Medication: Cholesterol lowering 0.3 0.5 0.6 -0.7 0.7
Depression (self-reported) 0.8 0.9 0.9 -0.9 1.0
Medication: Lansoprazole 0.1 0.1 0.2 0.0 0.4
Prospective memory result 3.9 4.8 5.4 2.3 -2.0
Lung cancer (father) 1.3 1.6 1.7 -1.2 1.3
Illnesses of mother 2.7 3.4 5.6 2.4 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.7 4.6 0.9 -2.1
Pulse wave Arterial Stiffness index 0.8 0.9 1.2 -1.1 0.8
Impedance of arm (left) 1.3 6.2 7.8 -2.2 2.8
Arm fat mass (right) 3.7 15.4 19.4 -3.4 4.4
Trunk predicted mass 1.2 6.8 12.2 1.2 -3.5
Standing height 1.3 13.4 25.0 1.3 -5.0
Length of working week for main job 3.7 4.0 4.3 2.1 -1.9
Exposure to tobacco smoke at home 0.6 0.7 0.9 -0.7 0.9
Breastfed as a baby 0.5 0.6 0.7 -0.8 -0.7
Tense / ‘highly strung’ 0.6 1.0 1.3 -0.9 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.9 -0.4 0.9
Hair/balding pattern: Pattern 4 1.0 2.5 2.9 -1.5 1.7
Birth weight of first child 0.7 1.3 2.0 0.8 -1.4
Peak expiratory flow (PEF) 0.1 0.2 0.4 0.2 -0.7
Pulse wave reflection index 1.9 2.4 3.7 1.0 -1.9
Ever highly irritable/argumentative for 2 days 1.2 1.5 1.7 -1.1 1.3
Loud music exposure frequency 1.2 1.4 1.8 -1.4 0.9
Qualifications: O levels/GCSEs or equivalent 1.2 2.0 2.3 1.2 -1.5
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 0.9 0.6 -1.0
Blood clot in the leg (DVT) 0.4 0.6 1.0 -1.0 -0.3
Medication: Paracetamol 0.1 0.2 0.4 -0.3 0.6
Headache pain in last month 0.2 0.3 0.6 -0.7 -0.3
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.3 -0.4 0.5
Glaucoma (self-reported) 1.4 1.7 2.0 -1.2 1.4
Gout (self-reported) 1.3 1.8 3.5 -0.3 1.9
Hypothyroidism/myxoedema (self-reported) 2.7 5.3 7.7 -1.7 2.8
Medication: Amlodipine 0.1 0.1 0.1 -0.4 -0.2
Medication: Ventolin 100micrograms inhaler 0.9 1.2 2.0 -0.6 1.4
Birth weight 0.5 1.1 2.2 0.2 -1.5
Chronic bronchitis/emphysema (mother) 9.1 10.6 12.3 -3.0 3.5
High blood pressure (siblings) 0.7 0.9 1.5 -0.6 1.2
Forced vital capacity (FVC), Best measure 1.4 5.0 7.7 1.5 -2.8
Body fat percentage 5.9 23.3 31.7 -3.9 5.6
Leg fat percentage (right) 4.0 14.6 21.7 -2.8 4.7
Arm fat-free mass (right) 0.6 3.3 6.2 0.7 -2.5
Exposure to tobacco smoke outside home 0.7 1.0 1.8 0.4 -1.3
Comparative body size at age 10 2.2 5.9 7.7 -2.0 2.8
Number of full brothers 2.7 3.4 3.5 -1.8 1.9
Worry too long after embarrassment 0.2 0.3 0.3 -0.6 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.5 0.2
Wheeze or whistling in the chest in last year 4.6 8.2 11.5 -2.2 3.4
Number of children fathered 0.1 0.1 0.2 0.2 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.0 0.5 -1.0
Age at first live birth 0.8 1.3 1.9 0.9 -1.4
Pulse wave peak to peak time 0.8 1.0 1.1 1.0 -0.9
Health satisfaction 1.1 1.4 1.7 -1.1 1.3
Shortness of breath walking on level ground 0.8 0.9 1.8 0.0 1.3
Qualifications: College or University degree 1.4 4.5 8.5 0.6 -2.9
Eye problems/disorders: None of the above 3.4 3.9 5.4 2.3 -1.6
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.2 0.3 0.5
Emphysema/chronic bronchitis 6.2 7.0 7.5 -2.5 2.7
Medication for pain relief, constipation, heartburn 0.0 0.1 0.2 0.4 -0.1
Neck or shoulder pain in last month 1.7 2.4 3.3 -1.8 1.2
Medication: Blood pressure 0.2 0.3 0.5 0.7 -0.2
Angina (self-reported) 0.3 0.3 0.6 -0.2 0.8
Migraine (self-reported) 2.4 3.0 4.0 1.4 -2.0
Medication: Ibuprofen 1.1 1.3 1.6 -1.3 1.0
Medication: Allopurinol 2.4 3.2 4.9 -1.2 2.2
Medication: Omeprazole 0.9 1.1 1.5 1.2 -0.8
Medication: Seretide 50 evohaler 1.3 1.5 1.9 -1.0 1.4
Mean time to correctly identify matches 3.8 7.3 8.0 2.6 -2.8
Heart disease (mother) 0.4 0.5 0.8 -0.9 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.1 0.1 0.3 -0.2
Whole body fat mass 3.1 12.7 15.9 -3.1 4.0
Leg fat mass (right) 2.5 9.8 13.6 -2.5 3.7
Arm predicted mass (right) 0.7 3.5 6.4 0.8 -2.5
Pulse rate, automated reading 3.3 10.8 12.9 -2.9 3.6
Alcohol intake frequency. 2.0 4.6 6.0 1.8 -2.4
Comparative height size at age 10 0.2 1.4 2.7 -1.6 -0.2
Number of full sisters 2.4 2.9 3.4 -1.5 1.9
Suffer from ‘nerves’ 1.0 1.6 1.9 -1.4 1.2
Overall health rating 2.2 4.7 6.1 -1.8 2.5
Chest pain or discomfort 0.1 0.2 0.3 0.4 0.5
Had major operations 1.8 2.2 2.6 1.6 -1.3
Age at last live birth 0.2 0.2 0.4 -0.3 0.6
Family relationship satisfaction 0.1 0.1 0.2 -0.1 -0.5
Leg pain on walking 1.1 1.3 2.6 -0.3 1.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.3 -0.2 0.6
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.7 0.1 0.9
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 2.8 1.7 -1.6
Medication: Aspirin 0.6 0.8 1.6 -1.3 0.3
Supplements: Vitamin C 0.3 0.4 0.7 -0.8 0.3
Knee pain experienced in last month 2.3 3.5 3.9 -1.8 2.0
Hypertension (Self-reported) 0.0 0.1 0.1 0.2 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.2 -0.6 1.5
Illnesses of father: Heart disease 3.4 4.7 5.3 -2.0 2.3
Illnesses of siblings: Diabetes 4.8 5.9 6.6 -2.3 2.6
Smoking status: Previous 0.9 1.3 2.6 -0.1 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.1 1.4 -0.9 -1.2
Whole body fat-free mass 0.4 2.5 4.9 0.4 -2.2
Leg fat-free mass (right) 0.1 0.3 0.3 -0.5 -0.6
Arm fat percentage (left) 7.6 30.4 40.8 -4.5 6.4
Average weekly red wine intake 0.1 0.1 0.2 -0.0 -0.4
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.2 0.7 -1.1
Mood swings 0.1 0.1 0.2 -0.4 0.3
Loneliness, isolation 2.0 2.8 3.0 -1.7 1.6
Long-standing illness, disability or infirmity 2.2 3.3 3.4 -1.8 1.8
Ever had bowel cancer screening 3.2 3.8 4.0 -2.0 1.9
Diabetes diagnosed by doctor 2.1 3.5 4.5 -2.1 1.6
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 2.3 -1.5 0.8
Friendships satisfaction 0.0 0.1 0.1 -0.3 0.0
Qualifications: nursing, teaching 0.0 0.0 0.1 0.1 -0.2
Commuting to job workplace: Walk 0.0 0.0 0.1 -0.0 -0.3
Eye problems/disorders: Cataract 0.6 0.7 1.1 -0.6 1.1
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.7 1.3 -0.6
Medication for cholesterol 0.0 0.0 0.0 0.1 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 1.5 -1.2 1.0
Back pain experienced in last month 0.1 0.1 0.2 -0.5 0.1
Mineral and other dietary supplements 0.1 0.2 0.3 -0.6 -0.0
Breast cancer (self-reported) 1.1 1.3 2.3 1.5 -0.5
Asthma (self-reported) 0.2 0.4 0.6 -0.4 0.8
Osteoporosis (self-reported) 1.3 1.6 2.9 0.5 -1.7
Osteoarthritis (self-reported) 0.4 0.5 0.8 -0.9 0.4
Medication: Aspirin 0.5 0.6 1.1 -1.1 0.2
Medication: Gliclazide 2.5 2.8 3.1 -1.8 1.6
Illnesses of father: None of the above (group 1) 1.5 1.9 3.2 0.8 -1.8
Smoking status: Current 0.0 0.0 0.0 0.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.1 5.5 1.7 -2.3
Whole body water mass 0.5 2.6 5.1 0.5 -2.2
Leg predicted mass (right) 0.1 0.3 0.3 -0.6 -0.5
Arm fat mass (left) 3.9 16.0 19.6 -3.5 4.4
Number of self-reported non-cancer illnesses 5.3 9.2 9.7 -3.1 3.0
Average weekly champagne plus white wine intake 0.9 1.3 2.2 0.7 -1.5
Miserableness 0.0 0.1 0.1 0.4 0.2
Guilty feelings 2.3 3.5 4.6 -1.5 2.1
Wears glasses or contact lenses 0.1 0.1 0.2 0.2 0.4
Ever taken oral contraceptive pill 0.2 0.3 0.5 -0.2 0.7
Hearing aid user 1.0 1.1 1.7 1.3 -0.8
Mother’s age at death 0.0 0.0 0.0 -0.0 -0.2
Financial situation satisfaction 2.3 2.9 3.9 -1.4 2.0
Tinnitus: Yes, now most or all of the time 1.9 2.2 3.2 -1.1 1.8
Commuting to job workplace: Public transport 3.7 4.4 6.7 1.5 -2.6
Eye problems/disorders: Glaucoma 2.7 3.2 3.5 -1.7 1.9
Medication: Blood pressure 0.0 0.1 0.1 -0.3 -0.3
Pain type(s) experienced in last month: Hip pain 4.5 5.6 5.8 -2.3 2.4
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.0 -0.2 1.0
High cholesterol (Self-reported) 0.3 0.6 0.7 -0.8 0.6
Medication: Bendroflumethiazide 0.0 0.0 0.1 0.2 0.2
Medication: Paracetamol 0.0 0.0 0.0 0.2 0.2
Medication: Lisinopril 0.0 0.0 0.1 0.2 -0.2
Medication: Atorvastatin 0.1 0.2 0.3 -0.1 0.6
Illnesses of father: High blood pressure 0.1 0.1 0.2 0.4 0.1
Alcohol drinker status: Never 0.3 0.4 0.6 0.4 -0.7
Ever smoked 2.7 4.7 6.5 -1.7 2.5
Basal metabolic rate 0.1 0.7 1.3 -0.3 -1.1
Leg fat percentage (left) 3.7 13.4 20.0 -2.6 4.5
Arm fat-free mass (left) 0.3 1.7 3.3 0.3 -1.8
Number of operations (self-reported) 0.2 0.3 0.3 -0.5 -0.6
Average weekly beer plus cider intake 1.3 1.8 1.8 -1.3 1.4
Irritability 1.1 1.8 2.0 1.4 -1.3
Risk taking 2.5 3.6 4.6 -2.1 1.6
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.2 0.8 -1.1
Fractured/broken bones in last 5 years 0.4 0.5 0.9 0.3 -1.0
Age started oral contraceptive pill 0.1 0.2 0.3 -0.6 -0.0
Diastolic blood pressure, automated reading 0.0 0.0 0.0 -0.1 0.2
Ever depressed for a whole week 1.3 1.6 2.3 0.9 -1.5
Unable to work because of sickness or disability 0.6 0.7 1.0 -1.0 0.6
Commuting to job workplace: Cycle 0.2 0.3 0.4 -0.4 -0.6
Myopia 0.0 0.0 0.0 -0.1 -0.1
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.1 -0.4 0.2
Cholesterol lowering medication 0.4 0.7 0.8 -0.9 0.7
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.5 0.7 -0.2
Pain experienced in last month 0.6 1.1 1.9 1.4 -0.4
Supplements: Calcium 0.4 0.5 0.6 0.8 -0.6
Basal cell carcinoma (self-reported) 1.0 1.2 1.5 1.0 -1.2
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.4 -0.0 0.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 0.7 -0.8 -0.5
Heart disease (siblings) 0.1 0.1 0.2 -0.1 0.4
Alcohol drinker status: Previous 1.2 1.3 1.5 1.1 -1.2
Pack years of smoking 4.6 6.7 7.0 -2.5 2.6
Impedance of whole body 0.3 1.7 2.2 -1.1 1.5
Leg fat mass (left) 2.4 9.4 13.0 -2.4 3.6
Arm predicted mass (left) 0.4 2.2 4.1 0.4 -2.0