TWAS hub - CPEB3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.129	0.0376	1.5e-09	0.180	NA	0.173	NA	0.182	8.7e-13	NA	2.8e-12	NA	6.8e-13
2	GTEx	Whole Blood	0.043	0.0210	2.9e-03	0.008	NA	0.013	NA	0.016	5.3e-02	NA	1.9e-02	NA	1.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Chronic bronchitis/emphysema (mother)	9.1	10.6	12.3	-3.0	3.5
Diabetes (mother)	8.7	11.1	13.1	-3.6	3.0
Arm fat percentage (right)	7.7	30.5	41.2	-4.4	6.4
Arm fat percentage (left)	7.6	30.4	40.8	-4.5	6.4
Ulcerative Colitis (UC)	6.6	12.4	12.6	-3.5	3.5
Chronotype (morning person)	6.3	14.5	14.5	-3.8	3.8
Emphysema/chronic bronchitis	6.2	7.0	7.5	-2.5	2.7
Falls in the last year	5.9	8.0	8.9	-3.0	2.6
Body fat percentage	5.9	23.3	31.7	-3.9	5.6
Trunk fat percentage	5.8	23.3	30.9	-4.0	5.6
Breast Cancer	5.7	13.8	15.0	-3.9	3.6
Verbal and Numeric Reasoning (VNR)	5.6	13.5	18.3	2.9	-4.3
Intelligence (Savage-Jansen 2018)	5.4	16.7	22.4	3.3	-4.7
Number of self-reported non-cancer illnesses	5.3	9.2	9.7	-3.1	3.0
Illnesses of siblings: Diabetes	4.8	5.9	6.6	-2.3	2.6
Waist circumference	4.7	17.2	22.0	-3.5	4.7
Wheeze or whistling in the chest in last year	4.6	8.2	11.5	-2.2	3.4
Pack years of smoking	4.6	6.7	7.0	-2.5	2.6
Pack years adult smoking proportion	4.5	6.8	7.0	-2.6	2.7
Pain type(s) experienced in last month: Hip pain	4.5	5.6	5.8	-2.3	2.4
Ulcerative Colitis	4.4	6.4	7.8	-2.8	2.2
Fluid intelligence score	4.4	9.1	13.3	2.2	-3.6
Irritable Bowel Disease (IBD)	4.2	10.0	11.1	-3.3	3.0
Number of live births	4.0	5.7	6.1	-2.5	2.3
Leg fat percentage (right)	4.0	14.6	21.7	-2.8	4.7
Had other major operations	3.9	4.7	4.9	-2.2	2.1
Prospective memory result	3.9	4.8	5.4	2.3	-2.0
Arm fat mass (left)	3.9	16.0	19.6	-3.5	4.4
Mean time to correctly identify matches	3.8	7.3	8.0	2.6	-2.8
Fed-up feelings	3.7	6.7	6.8	-2.6	2.6
Arm fat mass (right)	3.7	15.4	19.4	-3.4	4.4
Length of working week for main job	3.7	4.0	4.3	2.1	-1.9
Commuting to job workplace: Public transport	3.7	4.4	6.7	1.5	-2.6
Leg fat percentage (left)	3.7	13.4	20.0	-2.6	4.5
Coronary Artery Disease (CAD)	3.5	4.2	6.4	-2.5	1.4
Reaction Time	3.4	6.4	6.6	2.5	-2.6
Eye problems/disorders: None of the above	3.4	3.9	5.4	2.3	-1.6
Illnesses of father: Heart disease	3.4	4.7	5.3	-2.0	2.3
Medication: Co-codamol	3.3	3.8	5.7	-2.4	1.4
Pulse rate, automated reading	3.3	10.8	12.9	-2.9	3.6
Ever had bowel cancer screening	3.2	3.8	4.0	-2.0	1.9
Body mass index (BMI)	3.1	13.2	18.6	-2.8	4.3
Trunk fat mass	3.1	13.4	16.6	-3.2	4.1
Whole body fat mass	3.1	12.7	15.9	-3.1	4.0
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	6.2	-2.5	1.7
Pulse rate	2.8	4.8	7.0	-1.6	2.6
BMI	2.7	15.6	21.4	-3.1	4.6
Illnesses of mother	2.7	3.4	5.6	2.4	-1.1
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	7.7	-1.7	2.8
Number of full brothers	2.7	3.4	3.5	-1.8	1.9
Eye problems/disorders: Glaucoma	2.7	3.2	3.5	-1.7	1.9
Ever smoked	2.7	4.7	6.5	-1.7	2.5
Diabetes (father)	2.6	3.2	3.7	-1.6	1.9
Relative age of first facial hair	2.5	5.2	6.6	2.0	-2.6
Mouth/teeth dental problems: Dentures	2.5	4.3	4.9	-2.2	1.9
Leg fat mass (right)	2.5	9.8	13.6	-2.5	3.7
Medication: Gliclazide	2.5	2.8	3.1	-1.8	1.6
Risk taking	2.5	3.6	4.6	-2.1	1.6
Migraine (self-reported)	2.4	3.0	4.0	1.4	-2.0
Medication: Allopurinol	2.4	3.2	4.9	-1.2	2.2
Number of full sisters	2.4	2.9	3.4	-1.5	1.9
Leg fat mass (left)	2.4	9.4	13.0	-2.4	3.6
Knee pain experienced in last month	2.3	3.5	3.9	-1.8	2.0
Guilty feelings	2.3	3.5	4.6	-1.5	2.1
Financial situation satisfaction	2.3	2.9	3.9	-1.4	2.0
Comparative body size at age 10	2.2	5.9	7.7	-2.0	2.8
Overall health rating	2.2	4.7	6.1	-1.8	2.5
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	2.8	1.7	-1.6
Long-standing illness, disability or infirmity	2.2	3.3	3.4	-1.8	1.8
Maternal smoking around birth	2.1	3.1	5.8	-0.6	2.4
Noisy workplace	2.1	2.6	2.6	-1.6	1.6
Diabetes diagnosed by doctor	2.1	3.5	4.5	-2.1	1.6
Worry (Nagel 2018)	2.0	4.3	5.0	-1.9	2.2
Blood Platelet Count	2.0	22.7	25.1	5.0	-4.5
Average weekly fortified wine intake	2.0	2.3	3.0	-1.7	1.3
Alcohol intake frequency.	2.0	4.6	6.0	1.8	-2.4
Loneliness, isolation	2.0	2.8	3.0	-1.7	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.1	5.5	1.7	-2.3
Type 2 Diabetes (T2D) (2018)	1.9	3.6	4.6	-2.1	1.6
Nervous feelings	1.9	3.5	3.7	-1.8	1.9
Pulse wave reflection index	1.9	2.4	3.7	1.0	-1.9
Tinnitus: Yes, now most or all of the time	1.9	2.2	3.2	-1.1	1.8
Neuroticism (Nagel 2018)	1.8	4.3	5.0	-1.9	2.2
Height	1.8	35.0	54.8	3.9	-7.4
Waist Hip Ratio (WHR)	1.8	8.2	8.8	-2.8	3.0
Townsend deprivation index at recruitment	1.8	2.5	4.7	-0.5	2.2
Hip circumference	1.8	7.6	9.2	-2.5	3.0
Had major operations	1.8	2.2	2.6	1.6	-1.3
Major Depression (MDD)	1.7	2.1	3.6	-0.8	1.9
Body Mass Index (BMI) (2010)	1.7	2.3	2.6	-1.6	1.4
Hypothyroidism (self reported)	1.7	3.9	5.4	-1.5	2.3
Medication: Levothyroxine sodium	1.7	2.9	4.3	-1.2	2.1
Chronic bronchitis/emphysema (father)	1.7	2.0	2.8	-1.1	1.7
Past tobacco smoking	1.7	3.2	5.6	0.9	-2.4
Neck or shoulder pain in last month	1.7	2.4	3.3	-1.8	1.2
Alzheimer’s Disease (including proxy)	1.6	2.4	2.9	1.4	-1.7
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	2.6	-1.6	1.2
Sitting height	1.5	10.5	20.5	0.7	-4.5
Illnesses of father: None of the above (group 1)	1.5	1.9	3.2	0.8	-1.8
Ovarian Cancer	1.4	1.8	2.9	-0.8	1.7
Prostate Cancer	1.4	2.0	3.0	-1.0	1.7
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.0	0.5	-1.7
Serious illness, injury or assault to yourself	1.4	1.7	2.1	-1.5	1.1
Impedance of arm (right)	1.4	6.6	8.5	-2.1	2.9
Glaucoma (self-reported)	1.4	1.7	2.0	-1.2	1.4
Forced vital capacity (FVC), Best measure	1.4	5.0	7.7	1.5	-2.8
Qualifications: College or University degree	1.4	4.5	8.5	0.6	-2.9
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.3	-1.5	0.8
Neuroticism	1.3	3.1	4.3	-1.4	2.1
Average weekly spirits intake	1.3	1.6	3.0	-1.7	0.2
Lung cancer (father)	1.3	1.6	1.7	-1.2	1.3
Impedance of arm (left)	1.3	6.2	7.8	-2.2	2.8
Standing height	1.3	13.4	25.0	1.3	-5.0
Gout (self-reported)	1.3	1.8	3.5	-0.3	1.9
Medication: Seretide 50 evohaler	1.3	1.5	1.9	-1.0	1.4
Osteoporosis (self-reported)	1.3	1.6	2.9	0.5	-1.7
Average weekly beer plus cider intake	1.3	1.8	1.8	-1.3	1.4
Ever depressed for a whole week	1.3	1.6	2.3	0.9	-1.5
Financial difficulties in last 2 years	1.2	1.6	1.7	-1.3	1.3
Neuroticism score	1.2	2.5	2.8	-1.5	1.7
Trunk fat-free mass	1.2	6.8	12.2	1.2	-3.5
Trunk predicted mass	1.2	6.8	12.2	1.2	-3.5
Ever highly irritable/argumentative for 2 days	1.2	1.5	1.7	-1.1	1.3
Loud music exposure frequency	1.2	1.4	1.8	-1.4	0.9
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	2.3	1.2	-1.5
Alcohol drinker status: Previous	1.2	1.3	1.5	1.1	-1.2
Alzheimer’s Disease (in mother)	1.1	1.3	2.4	0.4	-1.6
Hand grip strength (left)	1.1	2.8	4.0	1.2	-2.0
Diabetes (self-reported)	1.1	1.7	2.6	-1.6	0.9
Health satisfaction	1.1	1.4	1.7	-1.1	1.3
Medication: Ibuprofen	1.1	1.3	1.6	-1.3	1.0
Leg pain on walking	1.1	1.3	2.6	-0.3	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.2	-0.6	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	1.5	-1.2	1.0
Breast cancer (self-reported)	1.1	1.3	2.3	1.5	-0.5
Irritability	1.1	1.8	2.0	1.4	-1.3
Had menopause	1.0	1.3	1.3	-1.2	1.1
Mouth/teeth dental problems	1.0	1.5	1.6	1.3	-1.2
Hair/balding pattern: Pattern 4	1.0	2.5	2.9	-1.5	1.7
Suffer from ‘nerves’	1.0	1.6	1.9	-1.4	1.2
Hearing aid user	1.0	1.1	1.7	1.3	-0.8
Basal cell carcinoma (self-reported)	1.0	1.2	1.5	1.0	-1.2
Schizophrenia vs Biploar Disorder	0.9	1.2	1.4	1.2	-1.0
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.3	-1.1	1.1
Ever had hysterectomy (womb removed)	0.9	1.0	1.9	-0.3	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.7	4.6	0.9	-2.1
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.0	-0.6	1.4
Medication: Omeprazole	0.9	1.1	1.5	1.2	-0.8
Smoking status: Previous	0.9	1.3	2.6	-0.1	1.6
Average weekly champagne plus white wine intake	0.9	1.3	2.2	0.7	-1.5
Smoking Status	0.8	1.8	3.5	-0.4	1.9
Hand grip strength (right)	0.8	2.1	3.8	0.7	-2.0
Age when periods started (menarche)	0.8	2.0	3.5	1.9	-0.7
Allergy	0.8	1.8	2.7	1.6	-1.0
Weight	0.8	3.9	4.2	-2.0	1.9
Depression (self-reported)	0.8	0.9	0.9	-0.9	1.0
Pulse wave Arterial Stiffness index	0.8	0.9	1.2	-1.1	0.8
Age at first live birth	0.8	1.3	1.9	0.9	-1.4
Pulse wave peak to peak time	0.8	1.0	1.1	1.0	-0.9
Shortness of breath walking on level ground	0.8	0.9	1.8	0.0	1.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.2	0.8	-1.1
Age at First Birth	0.7	1.0	1.5	0.8	-1.2
Number of treatments/medications taken	0.7	1.3	1.5	-1.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.3	-1.0	1.1
Illnesses of siblings	0.7	0.9	1.3	0.7	-1.2
Birth weight of first child	0.7	1.3	2.0	0.8	-1.4
High blood pressure (siblings)	0.7	0.9	1.5	-0.6	1.2
Exposure to tobacco smoke outside home	0.7	1.0	1.8	0.4	-1.3
Arm predicted mass (right)	0.7	3.5	6.4	0.8	-2.5
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.2	0.7	-1.1
Depressed Affect (Nagel 2018)	0.6	1.3	2.0	-0.7	1.4
Crohns Disease (2012)	0.6	1.0	1.6	-1.2	0.6
Supplements: Zinc	0.6	0.6	0.8	-0.9	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	0.8	-0.9	0.9
Qualifications: CSEs or equivalent	0.6	0.8	0.9	-1.0	0.8
Time employed in main current job	0.6	0.6	1.2	0.2	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.0	-1.0	0.7
Exposure to tobacco smoke at home	0.6	0.7	0.9	-0.7	0.9
Tense / ‘highly strung’	0.6	1.0	1.3	-0.9	1.1
Arm fat-free mass (right)	0.6	3.3	6.2	0.7	-2.5
Medication: Aspirin	0.6	0.8	1.6	-1.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.1	1.4	-0.9	-1.2
Eye problems/disorders: Cataract	0.6	0.7	1.1	-0.6	1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.7	1.3	-0.6
Unable to work because of sickness or disability	0.6	0.7	1.0	-1.0	0.6
Pain experienced in last month	0.6	1.1	1.9	1.4	-0.4
Schizophrenia (2018)	0.5	1.1	1.7	-1.3	0.7
Alzheimer’s Disease (in father)	0.5	0.5	0.9	1.0	-0.3
Crohns Disease (2017)	0.5	1.0	1.1	-1.0	1.0
Neuroticism (2016)	0.5	0.7	1.4	0.1	1.2
Rheumatoid Arthritis	0.5	0.7	1.0	1.0	-0.7
Triglycerides	0.5	0.8	1.5	-1.2	-0.1
Respiratory disease	0.5	1.2	1.3	-1.1	1.1
Medication: Atenolol	0.5	0.7	1.3	-1.2	0.1
Forced vital capacity (FVC)	0.5	1.8	3.5	0.5	-1.9
Breastfed as a baby	0.5	0.6	0.7	-0.8	-0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.9	0.6	-1.0
Birth weight	0.5	1.1	2.2	0.2	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	0.5	-1.0
Medication: Aspirin	0.5	0.6	1.1	-1.1	0.2
Whole body water mass	0.5	2.6	5.1	0.5	-2.2
Blood Red Count	0.4	3.5	3.8	1.8	-2.0
Lung FVC	0.4	2.2	2.9	1.7	-1.2
Sensitivity / hurt feelings	0.4	0.8	0.8	-0.9	0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	-0.9	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	0.3	-1.0
Alcohol intake versus 10 years previously	0.4	0.6	0.7	0.8	-0.8
Father’s age at death	0.4	0.5	0.6	-0.8	0.6
Worrier / anxious feelings	0.4	0.8	1.2	-1.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.4	0.1	-1.6
Blood clot in the leg (DVT)	0.4	0.6	1.0	-1.0	-0.3
Heart disease (mother)	0.4	0.5	0.8	-0.9	0.4
Whole body fat-free mass	0.4	2.5	4.9	0.4	-2.2
Osteoarthritis (self-reported)	0.4	0.5	0.8	-0.9	0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-0.2	1.0
Fractured/broken bones in last 5 years	0.4	0.5	0.9	0.3	-1.0
Cholesterol lowering medication	0.4	0.7	0.8	-0.9	0.7
Supplements: Calcium	0.4	0.5	0.6	0.8	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	-0.8	-0.5
Arm predicted mass (left)	0.4	2.2	4.1	0.4	-2.0
Mean Putamen Volume	0.3	0.4	0.5	-0.5	0.7
Fasting Glucose	0.3	0.4	0.7	0.8	-0.4
Allergy or Eczema	0.3	0.7	1.4	0.2	-1.2
Angina	0.3	0.4	0.6	-0.4	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	-0.9	-0.1
Alcohol usually taken with meals	0.3	0.5	0.6	-0.8	0.6
Qualifications: None of the above	0.3	0.7	1.3	-0.3	1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.2	0.5	-1.1
Asthma	0.3	0.7	1.1	-0.5	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	-0.9	0.4
Medication: Cholesterol lowering	0.3	0.5	0.6	-0.7	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	-0.4	0.9
Angina (self-reported)	0.3	0.3	0.6	-0.2	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	0.1	0.9
Supplements: Vitamin C	0.3	0.4	0.7	-0.8	0.3
High cholesterol (Self-reported)	0.3	0.6	0.7	-0.8	0.6
Alcohol drinker status: Never	0.3	0.4	0.6	0.4	-0.7
Arm fat-free mass (left)	0.3	1.7	3.3	0.3	-1.8
Impedance of whole body	0.3	1.7	2.2	-1.1	1.5
Bipolar Disorder or Schizophrenia	0.2	0.5	0.8	-0.9	0.3
Primary Biliary Cirrhosis	0.2	0.2	0.4	0.1	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.7	0.0
Systolic Blood Pressure	0.2	0.9	1.4	0.6	-1.2
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.8	-0.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.5	-0.7	0.2
Taking other prescription medications	0.2	0.3	0.4	-0.5	0.6
Multivitamins +/- minerals	0.2	0.3	0.5	0.3	-0.7
Supplements: Glucosamine	0.2	0.3	0.7	0.0	0.8
High blood pressure (mother)	0.2	0.2	0.4	-0.7	-0.2
Hearing difficulty/problems with background noise	0.2	0.4	0.5	0.7	-0.5
Pain all over the body in last month	0.2	0.2	0.3	-0.5	-0.4
Medication: Ramipril	0.2	0.2	0.4	0.6	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	-0.1
Happiness	0.2	0.2	0.5	-0.7	-0.1
Headache pain in last month	0.2	0.3	0.6	-0.7	-0.3
Worry too long after embarrassment	0.2	0.3	0.3	-0.6	0.5
Medication: Blood pressure	0.2	0.3	0.5	0.7	-0.2
Comparative height size at age 10	0.2	1.4	2.7	-1.6	-0.2
Age at last live birth	0.2	0.2	0.4	-0.3	0.6
Asthma (self-reported)	0.2	0.4	0.6	-0.4	0.8
Ever taken oral contraceptive pill	0.2	0.3	0.5	-0.2	0.7
Number of operations (self-reported)	0.2	0.3	0.3	-0.5	-0.6
Commuting to job workplace: Cycle	0.2	0.3	0.4	-0.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	0.7	-0.2
Bipolar Disorder (2018)	0.1	0.1	0.2	0.1	-0.5
HbA1C	0.1	0.1	0.2	-0.5	-0.2
HDL Cholesterol	0.1	0.1	0.3	-0.1	0.5
LDL Cholesterol	0.1	0.1	0.1	0.3	0.4
Lupus	0.1	0.2	0.2	-0.4	0.5
Schizophrenia (2014)	0.1	0.1	0.2	0.3	-0.5
Blood White Count	0.1	1.1	1.3	0.9	1.1
Heel T-Score	0.1	0.6	0.9	-1.0	0.6
Hair Pigment	0.1	1.4	2.0	-0.9	1.4
Tanning	0.1	0.6	0.9	0.6	-0.9
Systolic blood pressure, automated reading	0.1	0.2	0.2	0.5	-0.4
Medication for hormone replacement therapy	0.1	0.2	0.3	-0.6	0.0
Vitamin and mineral supplements	0.1	0.1	0.1	0.2	0.4
Medication: Metformin	0.1	0.2	0.3	-0.6	0.2
Severe depression (siblings)	0.1	0.1	0.2	-0.1	0.4
Current tobacco smoking	0.1	0.1	0.2	-0.1	0.5
Relative age voice broke	0.1	0.2	0.2	-0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	0.5	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	-0.5	-0.1
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.5	-0.1
Number of incorrect matches in round	0.1	0.1	0.2	-0.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.0	-0.6
Heart attack	0.1	0.1	0.3	0.0	0.5
Medication: Simvastatin	0.1	0.1	0.2	-0.2	0.4
Medication: Lansoprazole	0.1	0.1	0.2	0.0	0.4
Peak expiratory flow (PEF)	0.1	0.2	0.4	0.2	-0.7
Medication: Paracetamol	0.1	0.2	0.4	-0.3	0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.4	0.5
Medication: Amlodipine	0.1	0.1	0.1	-0.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	0.2
Number of children fathered	0.1	0.1	0.2	0.2	-0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.2	0.3	0.5
Chest pain or discomfort	0.1	0.2	0.3	0.4	0.5
Family relationship satisfaction	0.1	0.1	0.2	-0.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	-0.2	0.6
Leg fat-free mass (right)	0.1	0.3	0.3	-0.5	-0.6
Average weekly red wine intake	0.1	0.1	0.2	-0.0	-0.4
Mood swings	0.1	0.1	0.2	-0.4	0.3
Back pain experienced in last month	0.1	0.1	0.2	-0.5	0.1
Mineral and other dietary supplements	0.1	0.2	0.3	-0.6	-0.0
Leg predicted mass (right)	0.1	0.3	0.3	-0.6	-0.5
Wears glasses or contact lenses	0.1	0.1	0.2	0.2	0.4
Medication: Atorvastatin	0.1	0.2	0.3	-0.1	0.6
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.4	0.1
Basal metabolic rate	0.1	0.7	1.3	-0.3	-1.1
Age started oral contraceptive pill	0.1	0.2	0.3	-0.6	-0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	-0.0	0.6
Heart disease (siblings)	0.1	0.1	0.2	-0.1	0.4
Depression (Nagel 2018)	0.0	0.0	0.1	-0.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.2	-0.1
Blood Eosinophil Count	0.0	0.1	0.2	-0.4	0.3
Cardiovascular Disease	0.0	0.0	0.1	-0.1	-0.3
Lung FEV1/FVC ratio	0.0	0.2	0.3	-0.6	-0.2
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.0	0.0
Impedance of leg (right)	0.0	0.1	0.2	-0.2	0.4
Leg fat-free mass (left)	0.0	0.2	0.3	-0.6	-0.2
High blood pressure	0.0	0.0	0.0	-0.0	-0.2
Impedance of leg (left)	0.0	0.0	0.1	-0.2	0.2
Leg predicted mass (left)	0.0	0.2	0.4	-0.6	-0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	0.4	0.1
Medication for pain relief, constipation, heartburn	0.0	0.1	0.2	0.4	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	0.3	-0.2
Hypertension (Self-reported)	0.0	0.1	0.1	0.2	-0.4
Friendships satisfaction	0.0	0.1	0.1	-0.3	0.0
Qualifications: nursing, teaching	0.0	0.0	0.1	0.1	-0.2
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.0	-0.3
Medication for cholesterol	0.0	0.0	0.0	0.1	0.0
Smoking status: Current	0.0	0.0	0.0	0.0	0.2
Miserableness	0.0	0.1	0.1	0.4	0.2
Mother’s age at death	0.0	0.0	0.0	-0.0	-0.2
Medication: Blood pressure	0.0	0.1	0.1	-0.3	-0.3
Medication: Bendroflumethiazide	0.0	0.0	0.1	0.2	0.2
Medication: Paracetamol	0.0	0.0	0.0	0.2	0.2
Medication: Lisinopril	0.0	0.0	0.1	0.2	-0.2
Diastolic blood pressure, automated reading	0.0	0.0	0.0	-0.1	0.2
Myopia	0.0	0.0	0.0	-0.1	-0.1
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.1	-0.4	0.2

Hub : Genes

CPEB3

Models

Trait associations