Hub : Genes

CPEB4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Frontal Cortex BA9	0.3932	0.1386	7.6e-03	-0.002	NA	0.028	NA	0.032	3.7e-01	NA	6.1e-02	NA	5.0e-02
2	METSIM	Adipose	0.0701	0.0211	1.0e-04	0.025	0.035	0.023	0.036	0.019	8.9e-05	4.4e-06	1.7e-04	3.0e-06	5.3e-04
3	NTR	Blood	0.0678	0.0154	1.4e-07	0.030	0.028	0.042	0.042	0.048	3.4e-10	1.4e-09	1.6e-13	1.4e-13	2.8e-15
4	ROSMAP	Brain Pre-frontal Cortex	0.0968	0.0276	1.2e-04	0.072	0.038	0.059	0.057	0.064	1.6e-09	9.3e-06	4.0e-08	6.9e-08	1.3e-08
5	YFS	Blood	0.5776	0.0245	0.0e+00	0.720	0.699	0.726	0.729	0.727	0.0e+00	0.0e+00	0.0e+00	0.0e+00	0.0e+00

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.7	2.2	0.6	1.5	0.2	-0.5	0.7
Bipolar Disorder or Schizophrenia	0.3	0.6	2.7	1.6	0.0	0.4	0.5	-0.3
Depressed Affect (Nagel 2018)	1.0	2.1	3.4	-1.2	1.9	0.9	-1.4	1.6
Depression (Nagel 2018)	0.2	0.3	0.7	-0.8	0.1	-0.0	-0.8	0.5
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.0	0.7	-0.7	-0.4	0.9	-1.4
Neuroticism (Nagel 2018)	1.5	3.6	5.6	-2.0	1.6	0.8	-2.3	2.4
Schizophrenia (2018)	0.6	1.2	2.6	1.6	-1.2	0.3	0.9	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.2	0.9	0.4	0.4	-0.9	-0.1	0.1
Worry (Nagel 2018)	1.2	2.6	5.5	-1.2	0.1	-1.3	-2.3	2.1
Alzheimer’s Disease (in mother)	0.7	0.8	1.4	0.0	0.6	-0.9	-1.2	1.2
Alzheimer’s Disease (in father)	3.8	4.2	8.1	-1.4	1.3	1.6	-2.8	2.5
Alzheimer’s Disease (including proxy)	2.2	3.2	6.7	-1.0	1.6	-0.2	-2.6	2.4
Crohns Disease (2017)	7.3	16.1	24.8	3.9	-4.0	-5.0	3.2	-3.9
Irritable Bowel Disease (IBD)	5.8	13.9	25.6	3.7	-3.4	-5.1	2.8	-3.3
Ulcerative Colitis (UC)	2.4	4.5	10.2	2.3	-1.5	-3.2	1.4	-1.6
Major Depression (MDD)	0.1	0.2	0.7	0.0	0.4	0.8	-0.1	0.1
Reaction Time	1.8	3.4	6.8	-2.6	1.7	-0.7	-1.7	2.0
Verbal and Numeric Reasoning (VNR)	1.7	4.0	7.8	1.6	-1.5	-1.3	2.4	-2.8
Breast Cancer	7.5	18.2	25.5	-4.5	3.9	2.4	-5.0	4.9
Ovarian Cancer	1.0	1.3	4.6	2.1	-1.3	-0.4	0.1	0.1
Prostate Cancer	0.3	0.4	1.4	-0.2	1.2	0.6	0.0	0.4
Age at First Birth	1.0	1.5	2.3	0.6	1.5	0.9	-1.4	1.4
Bipolar Disorder (2011)	0.0	0.0	0.1	-0.2	-0.1	-0.2	-0.2	0.2
Body Mass Index (BMI) (2010)	1.4	2.0	4.0	1.4	0.2	-0.4	1.9	-2.0
Coronary Artery Disease (CAD)	0.5	0.7	1.9	1.4	-0.1	-0.4	0.9	-0.6
Crohns Disease (2012)	8.2	13.2	18.2	4.1	-3.0	-4.3	3.1	-3.5
Mean Putamen Volume	1.8	2.1	4.6	0.0	-1.7	-0.7	2.2	-1.6
Fasting Glucose	4.6	5.5	9.2	2.7	-1.4	0.2	3.0	-3.0
HbA1C	0.6	0.7	1.8	-1.3	0.2	0.4	-0.8	0.8
HDL Cholesterol	1.6	2.7	4.0	1.2	-2.0	-1.8	1.1	-1.8
LDL Cholesterol	0.3	0.4	0.8	0.7	-0.7	-0.9	0.5	-0.5
Lupus	0.3	0.4	1.8	-0.4	1.3	0.1	-0.1	-0.1
Neuroticism (2016)	3.8	5.5	8.5	-2.1	2.9	1.4	-2.6	2.5
Primary Biliary Cirrhosis	0.4	0.6	1.3	0.2	-0.6	-0.7	1.1	-1.0
Rheumatoid Arthritis	0.4	0.5	0.8	-0.0	0.6	-0.9	-0.9	0.8
Schizophrenia (2014)	0.3	0.8	3.1	1.8	-0.4	0.2	0.7	-0.3
Triglycerides	0.8	1.3	2.3	-0.5	1.5	-0.5	-1.5	1.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.4	-0.8	0.6	-0.1	0.2
Ulcerative Colitis	0.6	0.9	2.6	1.2	-0.2	-1.6	0.2	-0.3
Blood Eosinophil Count	2.0	15.7	30.4	1.6	-4.5	-1.2	4.9	-5.5
Blood Platelet Count	0.9	10.9	17.7	-4.1	1.7	0.8	-4.1	4.2
Blood Red Count	3.2	31.3	46.0	6.6	-4.4	3.4	6.8	-6.0
Blood White Count	3.5	25.6	114.5	2.0	-2.0	10.7	2.4	-0.4
Heel T-Score	4.0	31.4	60.7	-5.5	7.8	-0.8	-5.7	5.8
BMI	1.7	9.9	24.2	-0.4	-1.5	-0.9	4.9	-4.7
Height	0.1	2.3	8.2	0.6	-2.9	-0.3	0.9	-1.4
Waist Hip Ratio (WHR)	21.6	97.2	174.2	-7.6	9.0	1.9	-13.0	13.2
Systolic Blood Pressure	5.6	28.0	43.8	5.8	-4.4	-1.8	6.3	-6.6
Smoking Status	7.7	18.4	23.2	-4.8	4.0	4.2	-4.1	4.2
Allergy or Eczema	0.5	1.4	2.4	0.5	-0.7	-1.4	1.3	-1.5
Cardiovascular Disease	4.9	16.2	23.3	3.8	-4.3	-1.7	4.6	-4.8
Hypothyroidism (self reported)	0.2	0.4	1.0	-0.8	-0.3	-1.0	0.3	-0.2
Respiratory disease	0.1	0.3	0.8	-0.2	0.8	-0.9	0.2	-0.2
Type 2 Diabetes (T2D) (2018)	2.3	4.3	7.6	-0.8	2.2	1.6	-2.8	2.4
Lung FEV1/FVC ratio	6.9	35.2	59.8	-4.8	5.6	2.6	-7.7	7.4
Lung FVC	0.2	0.9	2.1	1.5	-0.3	1.3	0.5	-0.4
Neuroticism	1.7	4.0	6.2	-2.2	1.7	-0.6	-2.3	2.5
Chronotype (morning person)	5.1	11.9	17.8	3.3	-4.2	-2.2	3.6	-3.6
Hair Pigment	0.1	1.7	4.7	0.1	-2.2	0.6	-1.3	1.2
Tanning	0.2	2.5	4.3	-1.8	2.1	1.8	-0.7	1.0
Hand grip strength (left)	0.3	0.8	3.0	-0.2	1.7	-0.0	-0.5	0.9
Number of treatments/medications taken	1.1	1.9	4.2	0.4	0.0	1.3	2.0	-1.8
Average weekly spirits intake	0.3	0.4	1.3	0.0	0.6	1.1	-0.5	0.3
Sensitivity / hurt feelings	5.6	9.6	20.8	-4.6	2.2	1.0	-3.2	3.3
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.5	-1.9	0.1	0.7	-1.0	0.6
Hearing difficulty/problems: Yes	0.6	0.9	3.4	0.1	1.0	1.8	0.3	-0.1
Relative age of first facial hair	0.5	0.9	1.9	-0.8	0.6	-0.5	-1.4	1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.4	0.1	-1.2	1.0	0.3	-0.7
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.4	-0.2	-0.8	1.3	-1.5	1.5
Ever had hysterectomy (womb removed)	1.8	2.0	3.2	-0.4	1.8	1.3	-1.7	1.5
Systolic blood pressure, automated reading	4.8	13.9	24.5	3.3	-3.5	0.0	4.7	-5.0
Eye problems/disorders: Diabetes related eye disease	3.6	3.9	4.8	-1.7	2.0	2.0	-1.9	2.2
Angina	0.9	1.2	4.6	2.1	0.8	0.2	0.6	-0.6
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.0	-0.2	-0.4	0.1	0.3
Vitamin and mineral supplements	1.1	1.5	4.8	0.8	-2.2	0.9	0.9	-0.8
Supplements: Zinc	3.0	3.2	7.9	-1.6	2.8	1.1	-1.3	1.7
Medication: Co-codamol	3.8	4.4	9.0	-1.5	1.0	1.8	-2.6	3.0
Medication: Metformin	2.9	4.1	5.8	-1.3	2.3	1.9	-2.4	2.1
Diabetes (father)	1.0	1.3	4.2	-2.0	0.3	1.0	-0.6	0.9
Diabetes (mother)	0.4	0.6	1.6	-0.1	-0.0	1.3	-0.9	0.6
Severe depression (siblings)	0.4	0.5	1.2	0.5	-1.1	-0.2	0.6	-0.7
Pack years adult smoking proportion	0.3	0.5	1.6	-0.3	0.4	1.3	0.6	-0.3
Impedance of leg (right)	1.4	6.9	12.3	-1.6	2.9	-0.1	-3.5	3.3
Leg fat-free mass (left)	2.3	12.1	26.6	0.3	-3.1	-0.6	5.2	-4.9
Trunk fat percentage	1.0	3.8	6.4	-1.4	-1.5	-1.5	2.5	-2.5
Hand grip strength (right)	0.4	1.0	4.0	0.2	2.0	0.3	-0.5	0.9
Townsend deprivation index at recruitment	0.2	0.3	1.2	-0.0	-1.1	0.5	0.0	-0.1
Current tobacco smoking	3.2	5.2	9.0	-1.6	1.2	2.3	-3.0	2.8
Average weekly fortified wine intake	1.2	1.4	2.4	-1.2	0.8	0.6	-1.5	1.5
Maternal smoking around birth	0.6	0.9	2.6	-1.6	0.6	0.2	-0.9	1.0
Fed-up feelings	3.0	5.5	8.9	-3.0	2.8	1.8	-1.9	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.4	-1.1	0.9	-0.5	-1.2	0.9
Relative age voice broke	0.6	0.9	2.8	-0.6	0.3	-1.7	-0.8	0.7
Taking other prescription medications	0.3	0.5	1.4	-0.3	-0.2	1.2	0.6	-0.6
Age when periods started (menarche)	0.3	0.7	1.3	-0.7	0.8	0.3	-1.1	1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.9	-0.6	0.5	1.4	0.4	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	3.3	7.5	10.9	-3.3	3.3	1.2	-2.7	2.6
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.3	0.2	0.7	-2.1	-0.7	0.7
Qualifications: CSEs or equivalent	1.1	1.5	3.3	1.8	-1.1	-0.0	1.3	-1.1
Serious illness, injury or assault to yourself	0.7	0.8	2.2	1.5	-1.4	0.2	-0.3	0.1
High blood pressure	2.8	7.9	12.0	3.2	-2.4	-0.6	3.4	-3.5
Hayfever, allergic rhinitis or eczema	1.0	2.1	3.7	1.3	-0.6	-1.7	1.5	-1.9
Multivitamins +/- minerals	0.6	0.7	2.0	-0.3	1.4	-0.8	-0.7	0.5
Stomach or abdominal pain in last month	0.5	0.6	1.2	-1.1	0.2	0.3	-0.9	1.0
Supplements: Glucosamine	1.5	2.0	7.3	-1.2	2.7	0.7	-0.3	0.7
Diverticular disease/diverticulitis (self-reported)	1.7	2.1	3.8	-0.4	1.6	1.9	-1.3	1.5
Medication: Atenolol	3.0	3.8	5.8	2.4	-2.3	-0.1	2.0	-2.0
Medication: Levothyroxine sodium	0.2	0.4	2.0	-1.4	0.2	0.1	0.2	0.1
Sitting height	0.6	4.4	12.1	0.5	-3.5	-0.7	1.9	-2.4
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	-0.9	-0.3	1.0	0.2	-0.2
High blood pressure (mother)	1.1	1.6	2.7	1.6	-0.9	-1.6	1.0	-1.0
Body mass index (BMI)	1.6	6.7	17.3	-0.8	-1.3	-0.1	4.2	-3.8
Impedance of leg (left)	1.2	5.7	12.5	-0.9	2.0	-0.8	-3.5	3.3
Leg predicted mass (left)	2.2	11.9	26.6	0.3	-3.1	-0.4	5.2	-4.8
Trunk fat mass	1.3	5.6	10.8	-1.4	-1.9	-1.2	3.3	-3.2
Waist circumference	0.9	3.2	11.9	-3.5	1.2	0.9	-0.7	1.0
Number of incorrect matches in round	0.8	1.3	2.4	0.2	0.4	1.4	-1.4	1.5
Past tobacco smoking	5.1	9.4	15.2	3.9	-3.0	-2.4	2.8	-3.0
Alcohol usually taken with meals	0.2	0.3	1.1	0.3	-0.5	-1.0	-0.2	0.3
Nervous feelings	0.2	0.3	1.4	-0.0	-0.1	-1.2	-0.2	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.9	-1.4	-0.2	-0.8	-1.0	0.6
Hearing difficulty/problems with background noise	0.5	0.8	3.6	-0.0	-0.1	1.9	0.4	-0.2
Hair/balding pattern: Pattern 2	1.8	2.3	6.9	-1.0	2.6	0.4	-1.4	1.4
Had menopause	0.9	1.1	3.5	-0.4	-0.5	1.9	-0.7	1.1
Had other major operations	2.8	3.4	5.0	-1.3	1.9	2.2	-1.7	1.9
Forced vital capacity (FVC)	0.2	0.9	3.1	0.8	0.6	1.8	0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	2.9	6.6	10.5	-3.2	3.2	1.6	-2.2	2.2
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	8.7	-0.8	2.9	-0.4	-1.1	0.9
Qualifications: None of the above	0.8	1.7	6.6	-2.6	-0.0	0.7	-0.7	1.0
Financial difficulties in last 2 years	0.3	0.5	1.2	-0.9	-0.3	1.1	-0.1	0.2
Mouth/teeth dental problems	1.0	1.5	5.0	0.6	2.2	1.5	0.1	-0.1
Heart attack	0.8	1.1	4.0	0.7	-0.3	-2.0	0.6	-0.5
Allergy	0.6	1.3	2.2	-1.1	0.7	1.5	-0.9	1.4
Pain all over the body in last month	3.9	4.2	7.5	-0.1	1.4	2.2	-2.5	2.7
Diabetes (self-reported)	3.7	5.8	7.4	-1.9	2.7	2.0	-2.7	2.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.3	0.9	-0.5	-0.1	0.9	-1.1
Medication: Ramipril	0.9	1.1	2.5	0.6	-0.4	-0.7	1.6	-1.5
Medication: Simvastatin	1.3	1.9	3.6	1.2	-1.9	0.8	1.4	-1.4
Fluid intelligence score	0.6	1.2	2.9	0.8	-0.8	0.0	1.5	-1.7
Illnesses of siblings	3.1	4.4	6.7	-2.1	2.2	-0.5	-2.4	2.6
Neuroticism score	2.5	5.2	11.0	-3.3	2.3	0.0	-2.2	2.2
Weight	1.5	7.5	17.2	-0.6	-2.2	-0.3	4.2	-3.9
Impedance of arm (right)	0.6	3.0	6.0	0.3	0.1	-2.4	-2.4	1.8
Arm fat percentage (right)	1.3	5.3	10.8	-1.1	-1.4	-1.4	3.3	-3.2
Trunk fat-free mass	1.1	6.5	15.6	0.3	-1.9	0.6	4.0	-3.6
Hip circumference	2.9	12.4	28.3	-0.2	-3.0	0.4	5.3	-4.9
Time employed in main current job	1.0	1.2	2.9	-1.0	1.2	1.7	-0.3	0.7
Alcohol intake versus 10 years previously	1.0	1.5	3.5	-1.6	1.9	0.4	-0.8	0.9
Father’s age at death	0.2	0.2	0.5	0.7	0.6	-0.1	-0.4	0.3
Worrier / anxious feelings	0.1	0.3	0.6	-0.8	-0.3	-0.6	-0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	-0.5	-0.0	0.9	-0.2	0.1
Falls in the last year	0.6	0.8	1.9	-0.4	-0.8	0.3	1.0	-1.4
Hair/balding pattern: Pattern 3	0.9	1.4	4.1	2.0	-1.4	0.3	0.4	-0.7
Number of live births	0.6	0.8	2.7	-1.0	0.4	1.6	-0.2	0.5
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	5.0	-1.0	2.2	2.2	-1.7	2.1
Pulse rate	2.2	3.8	8.6	0.8	-2.9	-0.8	2.1	-2.1
Happiness	3.5	4.2	6.6	-2.1	2.6	0.4	-2.3	2.2
Noisy workplace	0.6	0.7	1.6	0.1	0.9	-0.3	-1.0	1.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.7	-0.0	1.9	0.9	-1.4	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	0.2	-0.3	0.9	-1.2	0.9
Mouth/teeth dental problems: Dentures	0.9	1.5	4.6	-1.2	-2.1	-0.9	0.4	-0.4
Asthma	0.2	0.5	1.3	-0.3	1.1	-0.9	0.3	-0.3
Medication: Ibuprofen (e.g. Nurofen)	3.9	5.0	12.7	-2.4	3.6	0.5	-1.8	1.8
Medication: Cholesterol lowering	0.3	0.4	0.8	0.8	0.9	0.6	0.4	-0.2
Depression (self-reported)	1.3	1.6	3.9	-0.7	1.1	0.3	-2.0	1.5
Medication: Lansoprazole	0.2	0.2	0.7	-0.2	0.8	0.3	-0.4	0.3
Prospective memory result	0.5	0.6	1.4	-0.6	0.9	-1.2	-0.7	0.5
Lung cancer (father)	2.5	2.9	4.9	-1.4	0.9	1.7	-2.2	2.0
Illnesses of mother	1.3	1.6	3.3	-1.8	0.7	1.8	-0.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.0	-0.5	1.4	1.3	-0.9	0.8
Pulse wave Arterial Stiffness index	0.6	0.7	1.9	-0.1	0.1	0.6	-1.4	1.2
Impedance of arm (left)	0.9	4.1	10.0	-0.1	0.5	-1.8	-3.2	2.6
Arm fat mass (right)	1.7	7.2	16.1	-1.2	-1.5	-1.2	4.0	-3.8
Trunk predicted mass	1.2	6.6	16.2	0.4	-1.8	0.6	4.0	-3.6
Standing height	0.1	1.1	4.2	0.5	-2.0	-0.7	0.5	-0.7
Length of working week for main job	0.3	0.3	0.8	-0.3	0.4	-0.9	-0.2	0.5
Exposure to tobacco smoke at home	2.4	2.6	4.4	-2.1	1.9	1.0	-1.4	1.5
Breastfed as a baby	0.7	0.9	1.4	-0.9	1.2	0.7	-1.0	0.9
Tense / ‘highly strung’	1.6	2.7	3.3	-1.8	1.8	-1.0	-1.8	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	3.1	4.7	14.0	-0.8	3.7	-0.5	-2.1	2.1
Hair/balding pattern: Pattern 4	0.7	1.6	2.9	0.1	-1.5	-0.7	1.6	-1.7
Birth weight of first child	0.9	1.7	2.5	-1.5	1.4	0.2	-1.4	1.6
Peak expiratory flow (PEF)	3.3	7.6	14.0	-1.9	3.7	2.1	-2.5	3.1
Pulse wave reflection index	1.4	1.7	2.8	-0.9	1.7	0.2	-1.7	1.4
Ever highly irritable/argumentative for 2 days	3.8	4.6	8.8	-0.8	2.1	1.0	-2.9	3.0
Loud music exposure frequency	0.6	0.7	2.3	-0.7	-0.2	1.5	-0.3	0.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	6.2	0.1	2.5	0.8	-0.9	0.8
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.2	1.6	-1.4	-2.0	-0.2	0.1
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.1	-0.6	-0.3	0.2	0.1
Medication: Paracetamol	0.7	1.1	2.0	-1.4	-0.1	1.1	1.2	-1.0
Headache pain in last month	0.5	0.8	1.6	-0.9	-0.6	-0.6	-1.3	1.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.8	-1.3	0.9	0.4	-1.5	1.7
Glaucoma (self-reported)	0.2	0.3	0.5	-0.4	0.5	0.6	-0.7	0.2
Gout (self-reported)	1.2	1.7	3.1	1.4	-0.7	-0.4	1.8	-1.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	-0.8	-0.2	-0.6	-0.1	0.0
Medication: Amlodipine	0.6	0.8	1.4	1.2	-0.7	0.9	0.9	-0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.2	0.2	0.4	-0.8	1.1	-0.9
Birth weight	0.4	0.8	2.6	-0.5	1.6	0.8	0.7	0.0
Chronic bronchitis/emphysema (mother)	2.1	2.4	4.1	1.3	-2.0	-1.0	1.5	-1.7
High blood pressure (siblings)	4.0	5.7	8.6	2.1	-2.9	-0.7	2.6	-2.9
Forced vital capacity (FVC), Best measure	0.3	1.3	2.2	1.0	-0.3	0.9	1.5	-1.5
Body fat percentage	1.0	3.8	6.9	-1.7	-1.3	-1.0	2.6	-2.5
Leg fat percentage (right)	0.8	3.1	6.7	-2.6	0.2	0.1	2.2	-1.9
Arm fat-free mass (right)	1.6	8.0	19.4	0.4	-2.3	0.2	4.4	-3.9
Exposure to tobacco smoke outside home	0.9	1.2	3.5	-0.6	-0.8	1.9	-0.7	1.1
Comparative body size at age 10	0.3	0.9	1.5	-0.5	0.7	1.2	1.2	-0.9
Number of full brothers	6.0	7.6	12.0	1.4	-3.5	-1.1	3.5	-3.3
Worry too long after embarrassment	0.2	0.3	0.8	-0.6	-0.4	-0.9	0.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.0	0.4	1.3	-1.6	-1.7	1.4
Wheeze or whistling in the chest in last year	0.4	0.7	3.0	-1.7	0.5	-0.2	0.0	-0.1
Number of children fathered	0.6	0.7	1.6	0.3	-0.5	-0.7	1.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	2.1	1.3	0.8	-1.3	1.4	-1.4
Age at first live birth	0.5	0.9	2.7	-0.1	1.6	-1.0	-0.8	0.4
Pulse wave peak to peak time	0.8	0.9	2.2	0.2	-0.3	-0.9	1.5	-1.3
Health satisfaction	0.3	0.3	0.8	-0.9	0.7	0.3	-0.4	0.3
Shortness of breath walking on level ground	0.3	0.3	0.8	0.6	0.9	0.1	0.4	-0.6
Qualifications: College or University degree	0.2	0.7	3.2	-0.1	0.6	-1.8	0.0	-0.2
Eye problems/disorders: None of the above	0.8	0.9	2.5	1.1	-0.7	-1.6	0.3	-0.4
Mouth/teeth dental problems: Loose teeth	1.0	1.1	4.7	-0.3	-2.2	-1.0	-0.2	-0.1
Emphysema/chronic bronchitis	0.7	0.8	3.6	-0.3	-1.9	-0.4	0.1	-0.3
Medication for pain relief, constipation, heartburn	1.6	2.7	7.2	2.7	-1.9	-1.6	0.4	-0.4
Neck or shoulder pain in last month	8.8	12.5	23.2	-4.8	3.8	1.7	-3.1	3.5
Medication: Blood pressure	1.1	1.9	3.4	1.9	-1.0	-0.6	1.4	-1.6
Angina (self-reported)	0.8	1.0	3.4	1.9	0.9	-0.0	0.6	-0.6
Migraine (self-reported)	1.2	1.6	3.4	-1.1	-0.2	0.6	-1.8	1.6
Medication: Ibuprofen	4.6	5.5	14.9	-2.2	3.9	0.9	-1.7	1.9
Medication: Allopurinol	2.1	2.8	3.9	2.0	-1.5	-0.1	2.0	-1.9
Medication: Omeprazole	4.4	5.3	14.3	-3.8	2.0	1.5	-1.8	1.6
Medication: Seretide 50 evohaler	0.5	0.6	2.4	0.3	0.7	-1.6	-0.1	-0.1
Mean time to correctly identify matches	5.0	9.6	14.5	-3.3	2.9	1.3	-3.5	3.8
Heart disease (mother)	0.4	0.5	0.8	0.9	-0.6	-0.7	0.7	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	6.8	1.0	2.6	1.6	1.5	-0.6
Whole body fat mass	1.5	6.4	13.4	-1.6	-1.8	-0.9	3.7	-3.5
Leg fat mass (right)	1.7	6.6	15.6	-1.7	-1.4	-0.2	4.0	-3.6
Arm predicted mass (right)	1.4	7.3	17.9	0.3	-2.0	0.6	4.2	-3.7
Pulse rate, automated reading	2.0	6.5	10.9	1.1	-3.3	-1.7	3.0	-2.9
Alcohol intake frequency.	1.8	4.2	12.0	2.1	-3.5	-1.4	1.0	-1.2
Comparative height size at age 10	0.6	3.4	9.1	1.3	-3.0	-0.5	1.7	-1.7
Number of full sisters	0.1	0.1	0.2	-0.4	0.4	-0.3	0.1	0.2
Suffer from ‘nerves’	1.1	1.7	3.1	-1.1	0.4	-1.5	-1.8	1.2
Overall health rating	1.5	3.2	7.5	-0.4	-1.2	0.7	2.6	-2.7
Chest pain or discomfort	0.1	0.1	0.2	0.5	0.4	0.3	0.3	-0.2
Had major operations	1.4	1.6	3.3	-1.1	1.3	1.8	-0.7	1.2
Age at last live birth	0.3	0.4	1.8	-0.1	1.3	-0.6	-0.3	0.0
Family relationship satisfaction	0.6	0.7	2.2	-0.0	1.5	1.0	-0.4	0.7
Leg pain on walking	0.4	0.5	1.0	-1.0	0.3	0.5	-0.7	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.3	0.2	0.6	0.6	-0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.6	-1.2	0.1	-0.3	-0.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.9	0.9	0.7	-0.9	0.4	-0.1
Medication: Aspirin	0.1	0.1	0.3	-0.0	-0.3	0.5	0.2	-0.3
Supplements: Vitamin C	0.8	1.0	2.9	-0.6	1.7	-0.8	-0.5	0.8
Knee pain experienced in last month	2.4	3.7	8.9	-3.0	1.8	2.2	-0.8	1.0
Hypertension (Self-reported)	3.5	9.6	15.1	3.3	-2.8	-0.8	3.7	-3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	2.5	-0.5	1.5	0.9	-1.6	1.3
Illnesses of father: Heart disease	2.4	3.4	6.5	0.8	-2.0	-0.4	2.6	-2.4
Illnesses of siblings: Diabetes	2.8	3.4	6.1	-0.0	0.6	2.3	-2.2	2.5
Smoking status: Previous	3.6	5.5	11.2	-3.3	2.5	1.7	-1.8	2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	-0.2	0.9	-0.1	0.1	0.0
Whole body fat-free mass	1.6	9.2	21.5	0.3	-2.5	0.1	4.6	-4.3
Leg fat-free mass (right)	2.3	12.2	24.9	0.7	-3.5	-0.8	5.0	-4.8
Arm fat percentage (left)	1.3	5.2	11.1	-1.0	-1.3	-1.2	3.3	-3.2
Average weekly red wine intake	0.9	1.3	2.3	-1.1	-1.5	-0.7	1.0	-1.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.6	-0.7	2.1	-0.0	-0.4	0.6
Mood swings	0.4	0.7	1.9	-1.4	-0.1	-1.0	0.4	-0.4
Loneliness, isolation	5.8	8.0	10.5	-3.0	3.2	1.3	-3.0	3.1
Long-standing illness, disability or infirmity	0.3	0.5	1.3	-0.3	1.1	0.7	-0.6	0.4
Ever had bowel cancer screening	2.0	2.4	4.0	-0.6	2.0	0.8	-1.8	1.9
Diabetes diagnosed by doctor	3.1	5.1	7.5	-1.4	2.4	2.0	-2.7	2.4
Ever had stillbirth, spontaneous miscarriage or termination	3.2	3.4	8.4	-2.9	2.1	0.7	-1.3	1.4
Friendships satisfaction	0.7	0.8	1.7	1.3	0.3	-1.1	0.7	-0.7
Qualifications: nursing, teaching	0.5	0.8	1.4	0.2	1.2	0.6	-1.2	0.9
Commuting to job workplace: Walk	0.3	0.3	1.0	-1.0	0.2	0.7	-0.3	0.3
Eye problems/disorders: Cataract	0.4	0.5	2.2	0.4	1.5	-0.0	-0.0	0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.8	1.5	-0.8	-1.9	0.6	-0.7
Medication for cholesterol	1.9	2.9	4.2	-1.5	2.0	0.3	-1.9	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.0	-0.8	0.6	-1.0	-1.0	0.7
Back pain experienced in last month	3.5	5.2	9.1	-3.0	1.1	3.0	-1.6	2.0
Mineral and other dietary supplements	0.6	0.9	3.2	0.8	-1.8	-0.3	0.1	-0.6
Breast cancer (self-reported)	0.3	0.4	0.8	0.9	0.3	0.8	0.5	-0.0
Asthma (self-reported)	0.3	0.7	2.3	-0.3	1.5	-0.9	0.2	-0.2
Osteoporosis (self-reported)	0.3	0.3	1.0	-0.1	0.7	-0.1	-1.0	0.5
Osteoarthritis (self-reported)	3.4	4.4	6.6	-2.5	2.6	2.0	-1.5	1.8
Medication: Aspirin	0.2	0.3	0.6	0.3	-0.4	0.8	0.6	-0.6
Medication: Gliclazide	6.5	7.4	15.5	-2.3	3.9	2.0	-2.2	2.7
Illnesses of father: None of the above (group 1)	2.7	3.3	6.6	-0.6	1.7	-0.5	-2.5	2.6
Smoking status: Current	3.7	5.8	8.9	-2.0	1.6	2.4	-3.0	2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	-0.2	0.9	0.7	-0.5	0.4
Whole body water mass	1.6	9.0	20.9	0.3	-2.5	0.0	4.6	-4.2
Leg predicted mass (right)	2.3	12.3	25.3	0.7	-3.5	-0.8	5.0	-4.8
Arm fat mass (left)	1.8	7.5	17.4	-0.9	-1.7	-1.1	4.2	-3.9
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	-0.0	0.5	0.5	0.7	-0.7
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.4	-0.1	-0.9	0.7	-0.6
Miserableness	2.0	3.5	5.9	-2.4	2.4	1.8	-1.1	1.1
Guilty feelings	2.4	3.5	6.2	-2.5	1.2	1.7	-1.9	1.9
Wears glasses or contact lenses	1.9	2.1	3.4	-1.5	-0.2	1.9	-1.7	1.4
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.2	-0.4	-0.5	0.6	-0.6
Hearing aid user	1.2	1.3	3.0	1.7	-0.9	1.1	0.9	-1.0
Mother’s age at death	1.6	2.0	3.8	-0.2	2.0	0.8	-1.5	1.7
Financial situation satisfaction	0.5	0.6	1.4	-1.2	0.7	1.0	-0.1	0.3
Tinnitus: Yes, now most or all of the time	2.7	3.1	5.9	-1.1	2.4	2.3	-0.9	1.5
Commuting to job workplace: Public transport	0.1	0.1	0.6	0.8	0.3	-0.0	-0.0	-0.3
Eye problems/disorders: Glaucoma	1.2	1.4	2.2	-1.5	1.3	1.1	-1.0	1.0
Medication: Blood pressure	4.6	8.7	13.2	3.3	-3.0	-0.7	3.2	-3.6
Pain type(s) experienced in last month: Hip pain	3.0	3.7	6.4	-2.5	0.4	1.9	-1.9	2.3
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.0	0.5	-0.1	-0.3	1.4	-1.0
High cholesterol (Self-reported)	0.3	0.4	1.7	0.6	-0.4	1.3	0.1	-0.1
Medication: Bendroflumethiazide	7.1	10.7	14.7	3.5	-3.7	-1.7	3.2	-3.8
Medication: Paracetamol	0.8	1.3	3.3	-1.8	0.6	1.3	0.9	-0.5
Medication: Lisinopril	3.5	4.5	9.3	1.8	-1.7	0.4	2.6	-3.0
Medication: Atorvastatin	0.8	1.0	3.1	0.5	1.8	1.3	0.2	0.3
Illnesses of father: High blood pressure	4.2	5.2	8.8	1.8	-2.1	-1.3	2.8	-3.0
Alcohol drinker status: Never	0.3	0.4	1.3	0.8	-1.1	-0.1	-0.2	-0.0
Ever smoked	7.0	12.3	16.0	-4.0	3.2	2.5	-3.8	3.8
Basal metabolic rate	1.7	9.7	22.7	0.0	-2.5	-0.2	4.8	-4.4
Leg fat percentage (left)	0.7	2.6	4.8	-2.1	-0.3	-0.1	2.2	-1.9
Arm fat-free mass (left)	1.6	7.9	19.6	0.1	-2.2	-0.1	4.4	-3.9
Number of operations (self-reported)	4.1	6.1	7.8	-1.9	2.8	2.5	-2.4	2.6
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.4	0.7	-0.6	0.5	-0.5
Irritability	1.4	2.4	5.4	-2.3	1.8	1.0	-1.2	1.1
Risk taking	1.2	1.7	3.4	-1.9	1.2	0.3	-1.2	1.5
Ever had prostate specific antigen (PSA) test	1.5	1.7	2.5	-1.6	1.5	1.1	-1.3	1.0
Fractured/broken bones in last 5 years	0.2	0.3	0.6	-0.4	-0.4	-0.8	-0.4	0.5
Age started oral contraceptive pill	0.6	0.7	2.3	0.9	-1.5	0.6	0.3	-0.2
Diastolic blood pressure, automated reading	11.8	36.5	70.5	3.9	-5.1	-2.6	8.0	-8.4
Ever depressed for a whole week	2.2	2.7	7.0	0.5	2.6	-1.6	-1.5	1.3
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.3	-0.7	-1.0	-0.7	0.3
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.5	0.2	-0.4	0.3	-0.0
Myopia	0.4	0.6	1.2	-1.1	-1.1	-0.5	-0.4	0.1
Vascular/heart problems diagnosed by doctor	3.1	8.4	12.3	-3.3	2.6	0.7	-3.4	3.5
Cholesterol lowering medication	0.9	1.4	2.5	1.0	-1.6	1.5	0.8	-0.7
Medication: Omeprazole (e.g. Zanprol)	3.3	4.0	10.5	-3.2	2.4	1.4	-1.0	1.0
Pain experienced in last month	5.7	9.4	16.2	4.0	-2.4	-3.1	2.5	-3.0
Supplements: Calcium	0.1	0.1	0.3	0.6	-0.4	-0.5	0.0	-0.1
Basal cell carcinoma (self-reported)	1.1	1.3	1.9	1.2	-1.4	1.2	0.8	-1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.5	0.7	-0.2	-1.9	0.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	-0.1	-0.6	-0.3	0.3	-0.0
Heart disease (siblings)	3.9	4.8	9.4	1.5	-1.8	-0.5	3.1	-3.0
Alcohol drinker status: Previous	1.8	2.0	8.5	1.0	-2.9	-0.9	0.1	-0.0
Pack years of smoking	0.2	0.4	1.5	-0.3	0.4	1.2	0.2	0.1
Impedance of whole body	1.1	5.4	12.8	-0.5	1.4	-1.5	-3.6	3.1
Leg fat mass (left)	1.6	6.4	14.7	-1.4	-1.7	-0.3	3.8	-3.5
Arm predicted mass (left)	1.5	7.5	19.2	0.0	-1.9	0.0	4.4	-3.8