TWAS hub - CPNE4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1430	0.0360	4.2e-07	0.028	0.067	0.071	0.067	0.069	2.3e-04	1.5e-08	4.7e-09	1.3e-08	7.7e-09
2	TCGA	Breast Invasive Carcinoma	0.0481	0.0158	2.2e-05	0.024	0.018	0.016	NA	0.015	7.7e-06	9.2e-05	2.2e-04	NA	4.4e-04
3	TCGA	Prostate Adenocarcinoma	0.0883	0.0319	6.6e-04	-0.002	0.027	0.018	NA	0.000	6.3e-01	7.4e-04	5.2e-03	NA	3.0e-01
4	TCGA	Thyroid Carcinoma	0.1230	0.0410	1.7e-04	0.029	0.030	0.013	NA	0.035	7.5e-04	6.5e-04	1.7e-02	NA	2.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Friendships satisfaction	4.2	5.2	8.4	-1.1	2.5	2.2	2.9
Qualifications: A levels/AS levels or equivalent	4.1	9.1	20.5	-1.4	1.9	3.2	4.5
Type 2 Diabetes (T2D) (2012)	3.4	3.9	7.3	-0.8	1.7	2.7	2.2
Commuting to job workplace: Cycle	3.4	4.1	8.5	-2.9	-0.1	2.6	0.9
Commuting to job workplace: Car/motor vehicle	3.2	3.7	10.5	1.9	0.6	-3.2	-0.6
Loud music exposure frequency	3.0	3.2	6.1	0.9	1.8	1.6	2.5
Number of full brothers	3.0	3.8	6.9	1.2	2.6	1.4	2.2
Family relationship satisfaction	3.0	3.7	8.6	-1.2	1.6	1.5	2.9
Happiness	2.9	3.5	7.0	-2.4	1.0	0.6	2.6
Hair/balding pattern: Pattern 2	2.8	3.6	6.6	-1.7	0.7	2.1	2.6
Frequency of depressed mood in last 2 weeks	2.7	3.8	7.2	1.9	2.7	-0.7	2.0
Mouth/teeth dental problems	2.7	4.2	9.3	-1.0	3.1	1.4	2.1
Qualifications: College or University degree	2.7	8.5	13.7	-1.5	2.5	3.7	3.5
Average weekly fortified wine intake	2.6	3.0	4.7	-2.1	0.5	1.6	2.2
Leg fat percentage (right)	2.6	9.3	26.2	5.1	-0.1	-3.2	0.9
Leg fat mass (right)	2.6	10.0	29.3	5.4	0.6	-2.7	1.7
Leg fat percentage (left)	2.5	8.9	25.3	5.0	-0.3	-3.1	0.9
Current tobacco smoking	2.4	4.0	8.5	0.9	-2.3	-1.2	-2.9
Tense / ‘highly strung’	2.4	3.9	6.2	-2.5	1.1	2.0	2.1
Body fat percentage	2.4	9.6	29.5	5.4	-0.5	-2.9	0.6
Heart disease (mother)	2.4	2.9	6.6	1.4	1.7	0.5	2.6
Smoking status: Current	2.4	3.8	7.6	0.7	-2.3	-1.4	-2.8
Tinnitus: Yes, now most or all of the time	2.4	2.9	8.5	0.7	-0.4	-2.9	-1.5
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	5.1	-1.3	-2.3	-2.0	-0.8
Major Depression (MDD)	2.3	2.8	5.9	2.4	-1.6	-0.6	-1.5
Leg fat mass (left)	2.3	9.0	26.2	5.1	0.4	-2.5	1.9
Trunk fat percentage	2.2	9.0	28.1	5.3	-0.6	-2.7	0.3
Waist circumference	2.2	7.9	18.8	4.3	0.9	-2.7	2.2
Qualifications: nursing, teaching	2.2	3.5	7.3	-0.9	0.3	2.7	2.4
Pain type(s) experienced in last month: Hip pain	2.2	2.7	6.6	0.9	-2.6	-0.2	-1.9
Qualifications: CSEs or equivalent	2.1	2.8	8.0	0.9	1.0	-2.8	-1.2
Trunk fat mass	2.1	9.0	28.2	5.3	0.3	-2.4	1.4
Falls in the last year	2.1	2.9	4.7	-2.0	-1.2	2.2	1.2
Mouth/teeth dental problems: Dentures	2.1	3.5	9.7	-0.9	-3.1	-0.3	-1.8
Whole body fat mass	2.1	8.9	27.4	5.2	0.2	-2.5	1.4
Lung cancer (father)	2.0	2.4	3.9	0.3	-2.0	-1.3	-1.9
Alcohol intake frequency.	2.0	4.6	10.1	3.2	1.1	-2.5	0.8
Age started oral contraceptive pill	2.0	2.5	5.6	-0.2	-1.9	0.8	-2.4
BMI	1.9	11.2	21.1	4.6	1.6	-1.8	4.2
Ever had hysterectomy (womb removed)	1.9	2.1	5.1	-0.3	-1.8	0.4	-2.3
Hip circumference	1.9	8.0	20.9	4.6	1.4	-1.6	2.6
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	8.7	0.1	0.5	1.8	2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	4.7	-1.3	1.7	0.8	2.2
Basal cell carcinoma (self-reported)	1.9	2.3	6.0	0.7	-1.6	-0.4	-2.4
Supplements: Glucosamine	1.8	2.4	4.7	-0.4	-2.2	0.4	-2.1
Ever highly irritable/argumentative for 2 days	1.8	2.2	6.0	-0.3	-2.4	-0.2	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	3.7	-1.9	-1.4	1.4	-0.9
Arm fat percentage (left)	1.8	7.3	23.2	4.8	0.1	-1.8	1.7
Risk taking	1.8	2.6	7.4	-1.1	1.2	0.6	2.7
Supplements: Calcium	1.8	2.0	6.2	-2.5	-0.5	0.7	-0.9
Alcohol drinker status: Previous	1.8	2.1	5.2	0.3	1.4	-1.0	2.3
Body Mass Index (BMI) (2010)	1.7	2.4	5.7	0.8	2.4	-0.5	1.7
Medication for hormone replacement therapy	1.7	1.9	4.0	-0.3	0.9	1.6	2.0
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	6.0	-0.5	-2.4	0.8	-1.0
Body mass index (BMI)	1.7	7.3	20.9	4.6	0.1	-1.8	2.2
Arm fat percentage (right)	1.7	6.7	22.1	4.7	0.0	-1.6	1.5
Time employed in main current job	1.7	2.0	4.2	-2.1	-1.5	0.7	-1.1
Arm fat mass (left)	1.7	6.9	20.0	4.5	0.5	-1.7	2.1
Intelligence (Savage-Jansen 2018)	1.6	5.1	7.6	-1.4	2.2	2.4	2.8
Alzheimer’s Disease (in mother)	1.6	1.9	6.6	-0.6	0.2	0.8	2.6
Bipolar Disorder (2011)	1.6	1.5	4.0	-0.6	-2.0	-0.4	-1.3
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.6	-0.8	-1.9	-1.3	-1.4
Financial difficulties in last 2 years	1.6	2.1	4.5	0.2	2.1	-0.4	1.9
Weight	1.6	8.0	19.7	4.4	1.5	-1.5	2.8
Arm fat mass (right)	1.6	6.5	20.1	4.5	0.4	-1.5	1.9
Eye problems/disorders: None of the above	1.6	1.9	3.5	1.9	1.2	-0.9	-1.3
Loneliness, isolation	1.6	2.3	4.2	-2.0	1.5	1.1	1.2
Medication: Paracetamol	1.6	2.4	5.6	0.4	1.1	1.7	2.4
Crohns Disease (2017)	1.5	3.2	7.8	-2.8	-1.6	1.6	0.2
Irritable Bowel Disease (IBD)	1.5	3.6	7.5	-2.7	-2.0	1.4	-0.9
Qualifications: None of the above	1.5	3.2	7.4	0.7	-0.4	-2.2	-2.7
Emphysema/chronic bronchitis	1.4	1.6	2.8	-1.7	-0.6	1.6	0.7
Medication: Omeprazole	1.4	1.7	3.8	-0.6	-1.5	-1.9	-0.6
Crohns Disease (2012)	1.3	2.0	4.7	-2.2	-0.7	1.5	0.8
Alcohol intake versus 10 years previously	1.3	1.9	5.0	2.2	0.7	-1.5	0.1
Pulse rate	1.3	2.3	8.2	-0.4	-0.9	-2.9	-0.1
Exposure to tobacco smoke at home	1.3	1.4	2.2	-1.1	0.2	-1.5	-1.5
Blood clot in the leg (DVT)	1.3	1.7	3.9	1.3	-1.1	-2.0	-0.1
Mineral and other dietary supplements	1.3	1.8	2.6	1.5	1.6	-0.9	1.2
Number of operations (self-reported)	1.3	2.0	3.1	-1.7	-0.8	1.8	1.2
Smoking Status	1.2	2.8	7.0	1.3	-2.6	-0.2	-1.6
Impedance of leg (left)	1.2	5.8	16.7	-0.4	-1.9	-1.7	-4.1
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	5.4	0.5	-0.8	-2.3	-0.3
Medication: Ventolin 100micrograms inhaler	1.2	1.6	6.2	0.3	-0.2	-2.5	-0.1
Forced vital capacity (FVC), Best measure	1.2	4.4	7.2	-1.8	2.7	1.6	2.2
Chest pain or discomfort	1.2	1.8	3.9	-0.7	-2.0	-0.8	-1.4
Average weekly red wine intake	1.2	1.7	3.2	-1.4	-1.1	1.8	0.8
Financial situation satisfaction	1.2	1.5	3.7	0.2	1.5	-0.1	1.9
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.3	-1.8	-0.8	1.2	-1.0
Depression (Nagel 2018)	1.1	1.7	3.4	1.6	1.8	-1.0	0.1
LDL Cholesterol	1.1	1.7	3.5	-0.8	-1.6	-0.5	-1.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	3.8	-0.4	-1.9	-0.5	-1.0
Supplements: Zinc	1.1	1.2	3.2	-1.8	-0.3	0.8	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.5	0.3	-0.5	-2.1	0.6
Eye problems/disorders: Cataract	1.1	1.3	2.0	-1.4	-1.3	0.9	0.8
Ever taken oral contraceptive pill	1.1	1.2	3.1	0.5	0.4	1.8	1.2
Ulcerative Colitis (UC)	1.0	1.9	3.0	-1.5	-1.7	0.6	-1.4
HbA1C	1.0	1.1	1.7	0.9	1.1	0.9	1.3
Pack years adult smoking proportion	1.0	1.5	5.4	-0.0	-0.2	-2.3	-0.8
Impedance of leg (right)	1.0	5.0	14.7	-0.5	-1.3	-1.8	-3.8
Serious illness, injury or assault to yourself	1.0	1.2	2.5	-0.5	1.6	0.5	1.3
Father’s age at death	1.0	1.3	2.7	-0.6	0.6	1.7	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	6.2	-1.4	2.5	1.1	2.0
Exposure to tobacco smoke outside home	1.0	1.3	3.4	-0.5	1.2	0.4	1.8
Shortness of breath walking on level ground	1.0	1.2	2.1	0.2	-1.5	-1.4	-0.8
Medication: Ibuprofen	1.0	1.2	2.7	1.6	0.9	1.1	0.4
Osteoarthritis (self-reported)	1.0	1.3	4.3	-0.6	0.6	0.1	2.1
Illnesses of father: None of the above (group 1)	1.0	1.3	2.3	1.4	0.8	1.5	-0.5
Medication: Lisinopril	1.0	1.2	3.5	-1.9	-0.3	1.1	0.4
Medication: Atorvastatin	1.0	1.2	3.6	0.1	-0.0	-1.1	1.9
Illnesses of father: High blood pressure	1.0	1.2	3.7	-0.6	-1.9	-0.5	-0.7
Pack years of smoking	1.0	1.5	4.7	-0.4	-0.4	-2.2	-1.0
Worry (Nagel 2018)	0.9	2.0	4.9	-2.2	-0.0	1.6	-0.8
Lung FVC	0.9	4.4	9.8	-2.4	0.6	3.1	1.4
Vitamin and mineral supplements	0.9	1.3	2.3	1.4	1.5	-0.6	-0.7
Diabetes (father)	0.9	1.1	3.7	1.9	-0.1	-0.8	-0.1
Leg fat-free mass (left)	0.9	5.0	9.6	2.6	2.0	-0.2	3.1
Leg predicted mass (left)	0.9	4.8	9.1	2.5	1.9	-0.2	3.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.4	1.6	0.5	1.2	-0.6
Pulse wave Arterial Stiffness index	0.9	1.1	4.2	0.1	-0.2	-2.0	0.2
Arm fat-free mass (right)	0.9	4.5	7.8	2.3	2.1	-0.6	2.8
Wheeze or whistling in the chest in last year	0.9	1.6	3.2	1.8	-1.2	-1.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.5	-0.0	-1.1	-1.2	-1.1
Osteoporosis (self-reported)	0.9	1.1	2.1	0.8	-0.2	-1.5	-1.2
Basal metabolic rate	0.9	4.9	8.6	2.6	2.1	-0.5	2.9
Unable to work because of sickness or disability	0.9	1.2	1.9	0.4	1.4	-0.9	1.3
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.3	1.2	-0.9	-1.5	0.3
Alzheimer’s Disease (including proxy)	0.8	1.2	3.0	-0.7	-1.0	-0.1	1.7
Medication: Co-codamol	0.8	0.9	1.7	0.8	0.5	-1.1	1.3
Fed-up feelings	0.8	1.4	4.8	0.6	0.0	-2.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.8	0.4	1.7	-0.5	1.0
Multivitamins +/- minerals	0.8	1.0	3.3	-0.9	-1.8	-0.2	0.3
Nervous feelings	0.8	1.5	4.9	-0.1	0.1	1.0	-2.2
Illnesses of mother	0.8	0.9	3.1	-0.7	-0.0	-0.5	-1.8
Headache pain in last month	0.8	1.4	2.9	0.2	1.3	1.7	1.1
Medication: Amlodipine	0.8	1.2	2.3	-1.0	1.5	-0.3	1.2
Comparative body size at age 10	0.8	2.1	6.3	1.4	-0.5	0.1	2.5
Age at first live birth	0.8	1.5	3.0	-1.6	0.4	1.7	0.4
Migraine (self-reported)	0.8	1.0	1.6	-0.2	1.2	0.9	1.3
Medication: Seretide 50 evohaler	0.8	0.9	2.7	-1.6	0.3	-0.7	0.5
Arm predicted mass (right)	0.8	4.2	7.5	2.4	1.9	-0.4	2.7
Number of full sisters	0.8	1.0	1.6	1.3	1.1	-0.8	0.8
Supplements: Vitamin C	0.8	1.0	2.6	-1.6	0.3	0.8	0.7
Smoking status: Previous	0.8	1.1	4.1	0.0	-0.4	2.0	0.4
Whole body fat-free mass	0.8	4.4	8.7	1.9	2.3	-0.0	3.0
Leg fat-free mass (right)	0.8	4.5	9.3	2.3	1.8	-0.0	3.0
Medication for cholesterol	0.8	1.2	3.0	-0.3	-1.2	-0.4	-1.7
Back pain experienced in last month	0.8	1.2	2.0	1.4	0.2	-1.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.7	-1.2	1.6	0.7	1.5
Whole body water mass	0.8	4.5	8.9	1.9	2.3	-0.1	3.0
Leg predicted mass (right)	0.8	4.3	8.9	2.3	1.8	-0.0	3.0
Hearing aid user	0.8	0.9	2.0	-1.4	0.4	-1.2	0.1
Arm fat-free mass (left)	0.8	3.9	7.2	2.2	1.7	-0.8	2.7
Impedance of whole body	0.8	4.0	12.6	-0.6	-1.4	-1.2	-3.5
Diabetes (mother)	0.7	0.9	3.1	-0.2	-0.4	0.3	1.8
Townsend deprivation index at recruitment	0.7	1.0	3.5	1.9	0.1	-0.4	-0.6
Relative age voice broke	0.7	1.1	2.3	-1.2	1.5	0.6	0.6
Number of incorrect matches in round	0.7	1.1	1.7	-1.3	-0.6	1.3	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.8	-0.7	1.3	-0.7	1.1
Forced vital capacity (FVC)	0.7	2.7	4.7	-1.1	2.2	1.3	1.7
Trunk fat-free mass	0.7	4.2	8.8	1.2	2.6	0.1	3.0
Worrier / anxious feelings	0.7	1.4	3.5	-1.9	-0.6	1.0	-0.8
Number of live births	0.7	0.9	3.6	0.1	-1.9	0.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	5.4	-0.8	2.3	0.7	1.8
Trunk predicted mass	0.7	4.2	8.5	1.2	2.6	0.1	2.9
Length of working week for main job	0.7	0.8	1.7	0.5	1.3	-0.1	1.1
Medication: Paracetamol	0.7	1.2	1.9	0.9	0.8	1.1	1.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.5	0.1	0.6	1.2	1.9
Pulse wave peak to peak time	0.7	0.8	3.1	0.1	0.3	1.8	-0.3
Leg pain on walking	0.7	0.9	2.9	0.8	0.2	-1.7	0.2
Breast cancer (self-reported)	0.7	0.9	1.8	0.6	1.3	0.8	0.9
Miserableness	0.7	1.2	3.9	-0.3	0.3	-2.0	-0.9
Arm predicted mass (left)	0.7	3.5	5.5	2.3	1.7	-0.5	2.3
Bipolar Disorder (2018)	0.6	0.9	2.2	-0.7	-1.5	-0.9	-0.4
Bipolar Disorder or Schizophrenia	0.6	1.4	4.1	-1.0	-2.0	-0.6	-0.1
Breast Cancer	0.6	1.4	2.6	1.5	1.6	0.8	0.4
Ulcerative Colitis	0.6	0.9	1.9	-1.4	-0.9	0.4	-0.9
Heel T-Score	0.6	4.4	9.0	0.5	3.0	-1.2	2.6
Number of treatments/medications taken	0.6	1.1	3.7	0.0	0.3	-0.8	1.9
Hearing difficulty/problems: Yes	0.6	0.9	1.5	-0.5	-0.9	-1.1	1.2
Medication: Metformin	0.6	0.8	1.5	0.8	-1.2	-1.0	0.4
High blood pressure (mother)	0.6	0.9	2.0	1.4	-0.4	-1.1	0.2
Noisy workplace	0.6	0.7	1.2	1.1	-0.0	-0.9	-0.9
Glaucoma (self-reported)	0.6	0.7	1.7	-1.3	-0.6	-0.5	-0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.1	-0.9	-1.0	0.5	0.7
Medication for pain relief, constipation, heartburn	0.6	1.0	3.6	-1.9	0.2	-0.2	-0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	0.9	-0.5	-1.1	-0.8
Ever had bowel cancer screening	0.6	0.7	1.3	-1.1	-1.2	0.3	-0.3
Diabetes diagnosed by doctor	0.6	1.0	2.7	-0.3	-1.6	-0.9	0.4
Commuting to job workplace: Public transport	0.6	0.8	2.5	-0.1	-0.0	0.7	1.6
Medication: Blood pressure	0.6	1.1	2.2	0.5	1.4	0.0	1.5
Fractured/broken bones in last 5 years	0.6	0.8	1.9	-0.5	0.8	0.6	1.4
Ever depressed for a whole week	0.6	0.7	1.7	-1.3	-0.5	0.8	0.4
Cholesterol lowering medication	0.6	0.8	1.7	1.3	-0.9	-0.8	-0.5
Heart disease (siblings)	0.6	0.7	2.3	0.3	-1.5	-0.3	-0.5
Alzheimer’s Disease (in father)	0.5	0.6	1.7	-0.5	-0.5	-0.1	1.3
Prostate Cancer	0.5	0.7	1.4	-0.4	0.9	1.2	0.8
Coronary Artery Disease (CAD)	0.5	0.6	1.0	0.0	0.9	1.0	0.7
Mean Putamen Volume	0.5	0.6	2.1	-1.4	0.0	-0.3	-0.5
Blood White Count	0.5	3.7	11.4	1.8	-0.2	-3.4	-0.2
Cardiovascular Disease	0.5	1.5	2.3	0.9	1.2	-1.2	1.5
Hypothyroidism (self reported)	0.5	1.3	3.0	-0.2	0.4	1.4	1.7
Average weekly spirits intake	0.5	0.6	1.5	0.3	0.6	1.2	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.0	-0.6	0.1	0.5	1.4
Hand grip strength (right)	0.5	1.5	3.8	1.9	1.3	0.1	0.8
Taking other prescription medications	0.5	0.7	2.2	-0.1	-0.4	-1.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.2	1.8	0.9	0.2	-0.6
Stomach or abdominal pain in last month	0.5	0.6	1.3	-0.5	-0.4	1.1	0.8
Hearing difficulty/problems with background noise	0.5	0.7	2.2	0.7	-0.3	-0.4	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.4	1.8	0.9	-0.5	-0.4
Diabetes (self-reported)	0.5	0.8	3.1	-0.2	-1.8	-0.1	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.2	0.3	-1.1	-0.7	-1.0
Fluid intelligence score	0.5	1.0	2.6	-0.8	0.9	-0.4	1.6
Impedance of arm (right)	0.5	2.5	7.5	-1.2	-1.1	-0.1	-2.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.6	1.3	-0.0	-0.9	-0.8
Birth weight of first child	0.5	0.9	2.5	0.4	-0.6	0.6	-1.6
Health satisfaction	0.5	0.7	1.1	-0.9	-1.0	-0.2	0.8
Number of self-reported non-cancer illnesses	0.5	0.9	2.6	0.2	-0.5	-1.6	0.7
Wears glasses or contact lenses	0.5	0.6	1.5	-0.8	-1.2	0.0	-0.3
Alcohol drinker status: Never	0.5	0.6	1.7	0.5	-0.5	-0.1	-1.3
Irritability	0.5	0.8	2.6	0.1	1.6	0.4	0.7
Depressed Affect (Nagel 2018)	0.4	0.9	2.1	-0.2	1.0	-1.4	-0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	-0.6	0.4	0.5	1.2
Reaction Time	0.4	0.7	1.3	-0.5	0.9	-0.6	1.1
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.6	-0.9	1.0	0.8	1.3
Ovarian Cancer	0.4	0.6	1.1	-0.5	0.4	1.0	0.9
Age at First Birth	0.4	0.6	1.3	-0.9	0.1	0.4	-1.1
HDL Cholesterol	0.4	0.7	2.3	-1.5	0.5	0.0	-0.5
Neuroticism (2016)	0.4	0.6	2.0	-0.2	-0.3	0.5	-1.4
Sensitivity / hurt feelings	0.4	0.8	1.6	-1.3	-0.4	0.8	0.7
Severe depression (siblings)	0.4	0.4	0.9	-0.5	-0.9	0.1	-0.8
Past tobacco smoking	0.4	0.7	1.7	-0.0	0.8	-1.3	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	0.5	-1.0	-0.8	0.3
Heart attack	0.4	0.5	1.4	0.3	-1.2	0.3	0.7
Pain all over the body in last month	0.4	0.4	1.0	0.4	0.5	0.5	1.0
Medication: Simvastatin	0.4	0.7	2.3	1.5	0.4	0.0	0.5
Neuroticism score	0.4	0.8	2.1	-1.4	0.5	0.9	-0.2
Medication: Lansoprazole	0.4	0.5	1.1	-1.0	-0.1	-1.0	0.3
Prospective memory result	0.4	0.5	1.2	-1.1	-0.9	0.2	-0.3
Impedance of arm (left)	0.4	2.0	6.2	-1.0	-0.8	-0.3	-2.5
Peak expiratory flow (PEF)	0.4	0.8	1.9	-0.2	1.4	0.4	1.1
Gout (self-reported)	0.4	0.6	1.6	-0.1	1.3	-0.2	-0.8
High blood pressure (siblings)	0.4	0.5	0.9	-0.4	-1.0	-0.9	-0.1
Medication: Allopurinol	0.4	0.6	0.9	-0.6	0.9	-0.9	-0.5
Had major operations	0.4	0.5	1.1	-0.6	-1.0	0.7	0.4
Age at last live birth	0.4	0.5	1.0	-0.3	-1.0	0.8	-0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.9	-0.5	-0.1	1.0	-0.8
Illnesses of father: Heart disease	0.4	0.5	1.0	-0.9	0.2	-0.3	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.3	0.0	0.5	0.3	1.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.5	-1.1	0.7	-0.3
Myopia	0.4	0.6	1.6	-0.2	-0.8	-0.3	-1.3
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.1	0.4	-1.0	0.2	1.0
Neuroticism (Nagel 2018)	0.3	0.6	1.8	-1.3	0.6	0.1	-0.6
Schizophrenia (2018)	0.3	0.6	2.1	-0.6	-1.5	-0.1	0.2
Primary Biliary Cirrhosis	0.3	0.4	0.9	-0.1	-0.9	-0.8	-0.0
Rheumatoid Arthritis	0.3	0.4	0.9	0.9	-0.8	-0.0	-0.1
Triglycerides	0.3	0.5	1.4	0.7	-0.2	0.0	1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.5	0.2	-1.2	0.2	0.9
Lung FEV1/FVC ratio	0.3	1.6	4.3	2.1	1.1	-0.4	1.0
Neuroticism	0.3	0.7	2.0	-1.4	0.4	0.4	-0.6
Hand grip strength (left)	0.3	0.9	3.1	1.8	0.1	0.6	-0.3
Angina	0.3	0.4	0.8	-0.9	0.3	0.8	0.3
High blood pressure	0.3	0.8	2.1	0.8	0.5	-1.4	0.3
Medication: Levothyroxine sodium	0.3	0.5	1.5	0.3	0.2	0.6	1.2
Alcohol usually taken with meals	0.3	0.5	1.7	-0.3	-0.3	1.3	0.0
Had other major operations	0.3	0.4	1.3	0.4	-0.2	0.5	1.1
Medication: Cholesterol lowering	0.3	0.5	1.8	-0.1	-1.3	-0.5	-0.2
Depression (self-reported)	0.3	0.4	0.9	0.4	-0.5	-0.5	1.0
Standing height	0.3	2.7	8.9	0.1	3.0	0.6	1.2
Pulse wave reflection index	0.3	0.4	0.7	-0.4	0.8	-0.8	0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	0.0	1.1	0.9	0.0
Birth weight	0.3	0.6	1.4	0.3	1.2	0.6	0.8
Worry too long after embarrassment	0.3	0.5	1.8	-1.4	-0.0	0.4	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	0.2	-0.9	-0.4	-0.6
Pulse rate, automated reading	0.3	1.0	3.2	0.6	-0.3	-1.8	0.5
Comparative height size at age 10	0.3	1.5	3.0	1.2	1.2	-1.7	0.1
Overall health rating	0.3	0.7	1.8	1.3	-0.7	-0.5	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	0.6	-0.5	-0.2	0.9
Medication: Aspirin	0.3	0.3	0.7	0.1	-0.8	0.8	0.1
Knee pain experienced in last month	0.3	0.5	1.0	1.0	-0.7	-0.6	0.2
Long-standing illness, disability or infirmity	0.3	0.4	1.3	0.4	-0.0	-0.2	1.2
Medication: Aspirin	0.3	0.4	1.3	-0.0	-0.4	1.1	0.4
Mother’s age at death	0.3	0.3	1.0	-0.5	-0.3	1.0	0.2
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	-1.0	-0.0	-0.6	-0.3
Average weekly beer plus cider intake	0.3	0.5	1.5	-0.5	1.2	0.4	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.8	-0.8	-0.6	1.3	-0.3
Blood Red Count	0.2	2.4	5.9	2.4	-0.6	-1.7	-0.6
Systolic Blood Pressure	0.2	1.0	1.4	0.2	1.2	-1.1	1.1
Allergy or Eczema	0.2	0.5	0.7	-0.8	-0.4	0.8	0.6
Respiratory disease	0.2	0.4	0.8	-0.7	0.9	0.0	0.5
Chronotype (morning person)	0.2	0.6	0.9	1.0	0.7	0.5	-0.7
Relative age of first facial hair	0.2	0.3	0.6	-0.7	0.8	-0.2	0.2
Maternal smoking around birth	0.2	0.3	0.6	-0.7	0.6	0.5	0.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.4	-0.5	-0.6	0.3
Sitting height	0.2	1.3	3.8	0.3	1.9	-0.6	0.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.3	-0.7	-0.5	0.3
Allergy	0.2	0.5	1.6	0.3	0.3	1.3	-0.4
Illnesses of siblings	0.2	0.2	0.8	-0.0	0.9	-0.0	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	0.3	-1.0	0.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	0.2	0.2	-0.4	0.8
Asthma	0.2	0.3	1.2	0.0	0.3	-1.1	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	0.7	-0.6	0.8	-0.8	-0.5
Number of children fathered	0.2	0.2	0.4	0.6	-0.2	0.5	-0.4
Medication: Blood pressure	0.2	0.3	1.1	-0.0	0.0	-1.0	-0.1
Angina (self-reported)	0.2	0.3	0.5	-0.7	0.2	0.7	0.2
Mean time to correctly identify matches	0.2	0.3	1.0	-0.2	0.5	-1.0	0.1
Hypertension (Self-reported)	0.2	0.5	1.2	0.5	0.5	-1.1	0.6
Illnesses of siblings: Diabetes	0.2	0.3	0.9	0.2	-0.9	-0.2	0.2
Commuting to job workplace: Walk	0.2	0.2	0.6	-0.8	0.5	0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.3	1.1	0.2	-0.5	0.1
Asthma (self-reported)	0.2	0.4	0.9	0.1	0.7	-0.9	0.4
Medication: Gliclazide	0.2	0.3	0.7	0.5	-0.2	-0.1	0.8
Medication: Bendroflumethiazide	0.2	0.4	0.8	0.4	-0.0	-0.9	-0.7
Ever smoked	0.2	0.4	1.2	-0.0	-0.7	1.1	0.3
Diastolic blood pressure, automated reading	0.2	0.7	1.0	1.0	0.8	-0.9	0.4
Pain experienced in last month	0.2	0.3	0.6	-0.7	0.4	-0.4	-0.8
Fasting Glucose	0.1	0.1	0.3	0.2	-0.1	0.5	0.2
Schizophrenia (2014)	0.1	0.3	0.7	0.2	-0.9	0.2	0.7
Blood Eosinophil Count	0.1	0.4	1.2	0.0	-0.6	-1.1	-0.4
Blood Platelet Count	0.1	0.9	2.8	-0.7	1.7	-0.1	0.7
Height	0.1	2.2	7.8	0.1	2.8	0.9	0.4
Waist Hip Ratio (WHR)	0.1	0.6	1.4	-0.2	-0.8	-1.2	-0.7
Tanning	0.1	1.0	2.0	0.5	0.3	1.2	-1.4
Age when periods started (menarche)	0.1	0.3	0.4	-0.5	0.5	0.6	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.0	-0.4	0.2	0.2	1.0
Medication: Atenolol	0.1	0.2	0.5	0.7	-0.4	0.2	0.1
Had menopause	0.1	0.2	0.4	0.3	-0.2	0.6	-0.3
Medication: Ramipril	0.1	0.2	0.4	-0.1	-0.5	-0.6	0.0
Breastfed as a baby	0.1	0.2	0.5	-0.1	0.3	0.7	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	-0.3	-0.2	0.4
Suffer from ‘nerves’	0.1	0.2	0.6	-0.5	0.1	-0.1	-0.8
Mood swings	0.1	0.1	0.3	0.2	-0.1	-0.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.5	0.7	-0.5	0.1	0.1
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.3	-0.4	0.0	0.5
Guilty feelings	0.1	0.2	0.4	0.7	0.4	0.3	-0.0
High cholesterol (Self-reported)	0.1	0.1	0.3	0.6	-0.1	0.1	0.3
Lupus	0.0	0.0	0.1	-0.1	-0.2	0.3	-0.1
Hair Pigment	0.0	0.4	1.1	-0.5	0.3	0.5	1.1
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.0	-0.2	-0.2	0.1
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.2	0.3	-0.3	0.4
Neck or shoulder pain in last month	0.0	0.1	0.1	0.3	0.3	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	-0.4	0.0	0.4	0.3

Hub : Genes

CPNE4

Models

Trait associations