Hub : Genes

CPNE7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.092 0.0310 3.4e-07 0.016 0.039 0.030 0.039 0.023 0.0039 1.4e-05 0.00013 1.4e-05 0.00067
2 METSIM Adipose 0.089 0.0277 1.4e-07 0.009 0.050 0.021 0.047 0.017 0.0160 4.5e-08 0.00029 1.4e-07 0.00110
3 TCGA Thyroid Carcinoma 0.063 0.0300 7.3e-03 0.013 0.018 0.008 NA 0.026 0.0160 7.0e-03 0.05000 NA 0.00130

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.3 3.7 9.6 -3.1 0.1 -1.2
Bipolar Disorder or Schizophrenia 4.5 11.0 29.1 -5.4 -0.3 -1.9
Depressed Affect (Nagel 2018) 0.3 0.6 0.9 -0.6 -0.9 0.7
Depression (Nagel 2018) 0.4 0.7 1.0 0.6 -1.0 0.8
Intelligence (Savage-Jansen 2018) 1.4 4.4 7.6 2.3 -2.8 0.4
Neuroticism (Nagel 2018) 0.3 0.6 0.8 0.6 -0.8 0.9
Schizophrenia (2018) 3.5 7.2 19.2 -4.4 -0.5 -1.5
Schizophrenia vs Biploar Disorder 1.1 1.5 2.6 -1.6 1.4 0.1
Worry (Nagel 2018) 0.3 0.6 0.9 0.8 -1.0 0.4
Alzheimer’s Disease (in mother) 0.3 0.3 0.5 -0.7 0.3 -0.6
Alzheimer’s Disease (in father) 0.9 1.0 1.7 -0.3 -1.0 -1.3
Alzheimer’s Disease (including proxy) 0.7 1.1 1.8 -1.0 -0.6 -1.3
Crohns Disease (2017) 0.2 0.4 0.8 -0.2 -0.6 0.9
Irritable Bowel Disease (IBD) 0.2 0.4 0.8 -0.2 -0.9 -0.5
Ulcerative Colitis (UC) 0.3 0.6 1.3 0.1 -0.8 -1.1
Major Depression (MDD) 3.5 4.3 9.8 -1.8 3.1 0.0
Reaction Time 0.0 0.1 0.1 -0.3 -0.3 0.0
Verbal and Numeric Reasoning (VNR) 2.0 4.7 7.9 2.8 -2.4 0.8
Breast Cancer 3.2 7.6 16.8 1.0 -4.1 -2.2
Ovarian Cancer 0.8 1.1 2.2 0.8 -1.5 -0.6
Prostate Cancer 0.9 1.2 2.6 -0.8 1.6 0.6
Age at First Birth 0.6 0.9 2.3 1.5 -0.6 -0.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 1.6 -1.3 1.0 -0.1
Coronary Artery Disease (CAD) 4.4 5.2 12.0 -0.4 -3.5 -1.9
Crohns Disease (2012) 0.0 0.1 0.2 0.5 0.0 0.0
Mean Putamen Volume 0.9 1.0 1.6 -1.2 -1.2 -0.4
Fasting Glucose 1.8 2.1 3.3 -1.8 0.9 -1.5
HbA1C 2.0 2.3 6.6 -2.6 0.2 -0.4
HDL Cholesterol 0.9 1.6 3.2 1.8 -1.1 0.6
LDL Cholesterol 0.9 1.4 2.3 -1.5 1.4 -0.3
Lupus 0.7 1.1 3.0 -1.7 0.5 0.2
Neuroticism (2016) 0.5 0.7 1.2 1.1 0.2 1.0
Primary Biliary Cirrhosis 0.9 1.3 3.2 -0.5 1.8 0.7
Rheumatoid Arthritis 2.1 2.9 6.0 -2.5 1.2 1.1
Schizophrenia (2014) 5.2 11.6 32.0 -5.7 1.1 -1.2
Triglycerides 2.7 4.4 9.6 -3.1 1.5 -1.1
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.2 -1.5 0.5 -0.7
Ulcerative Colitis 0.4 0.5 1.0 0.8 -1.0 0.0
Blood Eosinophil Count 0.1 0.4 1.2 0.1 0.2 1.1
Blood Platelet Count 0.1 1.2 2.3 1.2 0.2 1.5
Blood Red Count 0.3 3.0 7.7 0.7 2.8 -0.9
Blood White Count 0.6 4.8 14.2 0.1 0.3 -3.8
Heel T-Score 0.0 0.4 0.4 0.6 0.7 0.5
BMI 2.5 14.7 22.6 -4.8 4.5 -1.1
Height 0.8 15.5 33.3 3.3 -5.8 -1.6
Waist Hip Ratio (WHR) 0.3 1.1 2.7 -0.8 -1.6 -0.3
Systolic Blood Pressure 0.5 2.5 6.0 1.1 -2.5 0.6
Smoking Status 2.4 5.7 9.2 -3.0 -2.0 -2.0
Allergy or Eczema 0.7 1.8 2.5 -1.6 1.3 1.1
Cardiovascular Disease 2.6 8.5 16.4 3.0 -0.1 4.0
Hypothyroidism (self reported) 0.3 0.8 1.2 -1.1 1.0 -0.4
Respiratory disease 1.1 2.4 5.0 -2.2 -1.4 0.5
Type 2 Diabetes (T2D) (2018) 1.6 3.0 8.3 -2.9 0.8 -0.2
Lung FEV1/FVC ratio 0.2 1.0 1.3 1.1 1.0 0.8
Lung FVC 1.5 7.6 21.2 4.6 -1.2 -0.6
Neuroticism 0.3 0.8 1.4 -0.9 -0.5 1.2
Chronotype (morning person) 0.7 1.5 3.4 0.2 -1.1 -1.9
Hair Pigment 31.3 891.5 1584.0 39.8 -1.2 33.0
Tanning 57.3 699.0 1310.4 -36.2 -14.0 -24.3
Hand grip strength (left) 1.8 4.9 9.6 3.1 -2.1 0.8
Number of treatments/medications taken 1.0 1.8 3.0 -1.7 -1.1 1.1
Average weekly spirits intake 0.7 0.8 2.4 1.6 -0.2 0.1
Sensitivity / hurt feelings 0.1 0.2 0.3 -0.5 -0.1 -0.5
Frequency of depressed mood in last 2 weeks 0.0 0.1 0.1 0.1 0.4 0.2
Hearing difficulty/problems: Yes 0.6 0.9 1.3 -1.2 -0.8 0.9
Relative age of first facial hair 0.9 1.9 3.0 1.0 -1.7 1.2
Other serious medical condition/disability diagnosed by doctor 5.0 6.4 8.1 -2.8 -1.8 -2.9
Ever used hormone-replacement therapy (HRT) 1.0 1.2 3.7 0.1 -1.9 -0.2
Ever had hysterectomy (womb removed) 0.2 0.2 0.2 -0.4 -0.5 0.3
Systolic blood pressure, automated reading 0.3 0.9 2.2 0.4 -1.5 -0.7
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.8 -0.1 0.4 -1.3
Angina 0.7 0.9 2.5 -1.6 0.3 0.2
Medication for hormone replacement therapy 0.5 0.6 1.3 -0.2 -0.6 1.1
Vitamin and mineral supplements 0.7 1.0 2.4 1.6 -0.3 0.7
Supplements: Zinc 0.4 0.5 1.2 0.1 -0.4 -1.1
Medication: Co-codamol 0.9 1.0 2.0 -0.5 -1.4 -0.9
Medication: Metformin 0.2 0.3 0.7 -0.6 0.8 -0.0
Diabetes (father) 1.5 1.9 3.3 -1.8 0.3 -1.5
Diabetes (mother) 2.5 3.1 9.1 -3.0 0.4 0.3
Severe depression (siblings) 2.7 3.0 4.8 -2.2 -0.1 -2.1
Pack years adult smoking proportion 1.7 2.7 6.6 -2.6 1.2 0.1
Impedance of leg (right) 0.3 1.7 2.7 1.1 -1.1 1.6
Leg fat-free mass (left) 0.2 1.1 2.7 -1.6 0.1 -0.8
Trunk fat percentage 3.1 12.3 19.6 -4.4 4.1 -0.1
Hand grip strength (right) 1.4 3.9 8.4 2.9 -1.8 0.3
Townsend deprivation index at recruitment 2.9 4.0 5.8 -2.4 2.3 1.1
Current tobacco smoking 0.9 1.5 2.5 -1.6 -0.9 -1.1
Average weekly fortified wine intake 2.0 2.4 3.5 1.9 -1.8 -0.7
Maternal smoking around birth 1.3 1.9 3.1 -1.6 1.8 0.0
Fed-up feelings 0.6 1.1 2.8 -1.7 0.7 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.0 -0.1 0.0 0.0
Relative age voice broke 0.3 0.5 1.1 -0.5 -0.1 1.0
Taking other prescription medications 3.7 5.8 17.0 -4.1 0.4 -0.5
Age when periods started (menarche) 0.2 0.4 1.1 -0.1 1.1 -0.4
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.4 -0.3 -0.6 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.8 -1.0 0.3 -1.7
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 1.7 0.2 1.3 1.0
Qualifications: CSEs or equivalent 1.9 2.5 5.3 -1.3 2.3 -0.6
Serious illness, injury or assault to yourself 1.5 1.8 3.6 -0.2 -1.3 -1.9
High blood pressure 3.1 8.7 13.7 3.7 -1.5 3.2
Hayfever, allergic rhinitis or eczema 0.6 1.2 1.7 -1.2 0.7 1.3
Multivitamins +/- minerals 0.3 0.4 0.8 -0.9 -0.4 0.3
Stomach or abdominal pain in last month 2.9 3.6 8.5 -2.9 0.7 -1.3
Supplements: Glucosamine 0.1 0.2 0.4 -0.7 -0.3 -0.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 -0.4 -0.1 -0.7
Medication: Atenolol 3.4 4.3 7.1 2.4 -2.7 -0.0
Medication: Levothyroxine sodium 0.9 1.5 3.9 -2.0 0.1 -0.7
Sitting height 0.6 3.9 10.5 0.7 -3.2 -0.9
Chronic bronchitis/emphysema (father) 0.4 0.5 1.2 -1.1 0.3 0.4
High blood pressure (mother) 2.2 3.1 8.1 2.8 -0.3 1.0
Body mass index (BMI) 2.0 8.5 14.7 -3.8 3.0 -1.3
Impedance of leg (left) 0.4 2.2 3.4 1.5 -1.0 1.8
Leg predicted mass (left) 0.2 1.1 2.6 -1.6 0.0 -0.8
Trunk fat mass 1.8 7.9 15.6 -4.0 2.8 -0.4
Waist circumference 1.5 5.6 14.1 -3.8 1.7 -0.0
Number of incorrect matches in round 1.5 2.4 4.9 -1.1 -1.1 -2.2
Past tobacco smoking 2.2 4.1 5.6 1.8 2.4 1.8
Alcohol usually taken with meals 0.0 0.0 0.1 -0.2 0.3 -0.2
Nervous feelings 0.2 0.4 0.7 0.2 -0.7 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.3 2.5 -1.2 0.1 -1.6
Hearing difficulty/problems with background noise 0.8 1.3 2.8 -1.0 -1.7 0.4
Hair/balding pattern: Pattern 2 0.4 0.5 0.9 0.5 0.5 1.0
Had menopause 6.1 7.6 18.8 1.9 -4.3 -0.4
Had other major operations 2.3 2.8 4.7 -1.8 2.2 -0.6
Forced vital capacity (FVC) 1.5 6.0 14.7 3.8 -1.7 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.2 0.0 0.6 -1.1
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 3.6 -0.2 -0.9 -1.9
Qualifications: None of the above 0.3 0.6 1.7 -0.4 0.1 -1.3
Financial difficulties in last 2 years 1.1 1.5 2.8 -0.7 1.7 1.1
Mouth/teeth dental problems 2.3 3.5 7.6 2.8 -1.5 -0.9
Heart attack 0.2 0.3 0.4 -0.7 -0.6 0.1
Allergy 1.0 2.3 5.7 2.4 -1.0 -0.5
Pain all over the body in last month 1.1 1.2 2.0 -1.4 1.2 0.4
Diabetes (self-reported) 2.2 3.4 9.9 -3.1 0.5 0.1
Hayfever/allergic rhinitis (self-reported) 3.1 4.2 5.2 -2.0 1.8 2.3
Medication: Ramipril 0.5 0.7 1.9 0.2 -0.3 1.4
Medication: Simvastatin 0.2 0.3 0.3 -0.5 0.5 0.6
Fluid intelligence score 1.4 3.0 4.3 2.1 -2.0 0.7
Illnesses of siblings 0.7 0.9 1.7 -0.1 1.3 1.1
Neuroticism score 0.1 0.1 0.4 -0.6 -0.0 -0.1
Weight 0.6 2.9 7.1 -2.7 1.1 -0.5
Impedance of arm (right) 0.2 0.9 1.9 -1.4 -0.1 0.9
Arm fat percentage (right) 3.5 13.6 26.7 -5.2 3.7 -0.7
Trunk fat-free mass 0.5 2.8 7.8 0.2 -2.8 -0.8
Hip circumference 0.5 2.1 4.6 -2.1 1.3 0.2
Time employed in main current job 1.3 1.5 3.2 -1.1 -1.8 -0.2
Alcohol intake versus 10 years previously 2.1 3.1 6.4 -2.5 -0.4 -1.6
Father’s age at death 0.9 1.2 2.3 -1.1 -0.6 -1.5
Worrier / anxious feelings 0.7 1.4 2.7 0.1 -1.2 -1.7
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.5 5.6 -2.4 0.1 -1.4
Falls in the last year 1.3 1.8 2.7 -1.7 1.3 -1.0
Hair/balding pattern: Pattern 3 1.0 1.5 2.1 1.1 1.5 1.1
Number of live births 4.6 6.5 15.0 -0.8 -3.9 -2.0
Forced expiratory volume in 1-second (FEV1) 1.6 5.4 15.2 3.9 -1.0 -0.1
Pulse rate 1.0 1.7 3.0 0.4 1.7 -1.4
Happiness 0.2 0.3 0.6 -0.8 0.4 0.3
Noisy workplace 0.4 0.5 0.7 -0.8 -0.8 0.2
Qualifications: A levels/AS levels or equivalent 0.7 1.6 1.8 1.4 -1.1 1.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.9 -0.4 -1.0 0.0
Mouth/teeth dental problems: Dentures 2.1 3.6 8.4 -2.9 1.5 -0.1
Asthma 1.2 2.4 4.0 -2.0 -1.8 0.2
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 3.9 -1.0 0.0 2.0
Medication: Cholesterol lowering 0.7 1.1 2.1 -1.0 1.4 0.5
Depression (self-reported) 1.2 1.4 1.9 -1.4 -0.8 -1.3
Medication: Lansoprazole 5.7 6.5 9.7 -3.1 3.1 0.6
Prospective memory result 1.3 1.6 4.3 -0.1 0.7 2.1
Lung cancer (father) 0.1 0.1 0.2 -0.5 0.2 0.2
Illnesses of mother 0.8 1.0 2.4 -0.7 -0.2 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.8 13.1 3.6 -1.2 -0.1
Pulse wave Arterial Stiffness index 0.1 0.1 0.4 0.2 -0.1 -0.6
Impedance of arm (left) 0.2 0.8 1.8 -0.2 0.8 1.4
Arm fat mass (right) 2.2 9.2 19.2 -4.4 2.8 -0.8
Trunk predicted mass 0.6 3.2 8.7 0.3 -3.0 -1.0
Standing height 0.8 8.1 18.4 2.1 -4.3 1.3
Length of working week for main job 1.5 1.6 4.0 -0.2 2.0 -0.9
Exposure to tobacco smoke at home 0.4 0.5 0.8 -0.5 0.9 -0.7
Breastfed as a baby 1.1 1.4 1.6 -1.1 1.3 -1.1
Tense / ‘highly strung’ 0.3 0.6 1.0 0.7 -0.3 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.5 4.5 -2.1 0.9 -1.5
Hair/balding pattern: Pattern 4 1.3 3.2 9.2 3.0 0.3 0.6
Birth weight of first child 1.5 2.7 7.7 0.2 -2.8 0.5
Peak expiratory flow (PEF) 1.8 4.3 11.6 3.4 -1.0 -0.3
Pulse wave reflection index 1.4 1.8 3.3 1.4 -1.8 0.2
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.2 -0.2 0.2 1.1
Loud music exposure frequency 0.9 0.9 1.2 -1.1 -1.1 -0.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.6 0.0 0.0 1.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.9 -0.1 0.7 1.0
Blood clot in the leg (DVT) 1.8 2.3 4.4 -0.2 1.6 -2.1
Medication: Paracetamol 0.7 1.2 2.2 -1.0 -1.5 0.6
Headache pain in last month 0.9 1.5 3.9 -0.8 -2.0 -0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.9 0.1 -0.8 -1.4
Glaucoma (self-reported) 1.0 1.2 3.3 0.1 0.5 -1.8
Gout (self-reported) 0.3 0.5 0.8 -0.9 0.5 0.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.7 -1.3 0.4 -0.8
Medication: Amlodipine 2.2 3.1 6.6 2.6 -1.1 1.3
Medication: Ventolin 100micrograms inhaler 1.2 1.6 3.7 -1.9 -0.9 -0.4
Birth weight 2.3 5.0 13.2 0.1 -3.6 -1.3
Chronic bronchitis/emphysema (mother) 2.1 2.4 6.6 -2.6 -0.7 -0.3
High blood pressure (siblings) 0.9 1.2 1.9 1.4 -1.3 -0.3
Forced vital capacity (FVC), Best measure 1.4 5.3 11.2 3.4 -2.1 -0.2
Body fat percentage 2.8 11.2 18.9 -4.3 3.8 -0.3
Leg fat percentage (right) 1.7 6.2 12.7 -3.6 2.3 -0.7
Arm fat-free mass (right) 0.1 0.5 0.8 0.7 -0.9 -0.4
Exposure to tobacco smoke outside home 1.7 2.2 4.0 -2.0 1.6 -0.3
Comparative body size at age 10 0.9 2.4 7.0 0.2 0.3 -2.6
Number of full brothers 1.4 1.7 2.5 -1.5 0.7 1.6
Worry too long after embarrassment 1.1 1.8 5.1 0.5 2.3 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.0 -0.9 0.4 -1.0
Wheeze or whistling in the chest in last year 1.4 2.6 7.6 -2.8 0.1 -0.3
Number of children fathered 3.5 3.9 11.4 -0.5 -3.4 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 3.0 -1.7 -0.8 0.0
Age at first live birth 1.4 2.4 4.3 2.1 -1.2 -1.2
Pulse wave peak to peak time 0.1 0.1 0.4 -0.0 -0.2 0.6
Health satisfaction 3.3 4.2 9.2 -3.0 1.9 -0.0
Shortness of breath walking on level ground 2.6 3.0 6.0 -2.4 1.7 0.4
Qualifications: College or University degree 1.1 3.6 5.7 2.2 -2.4 -0.3
Eye problems/disorders: None of the above 0.4 0.5 1.0 0.8 -1.0 0.1
Mouth/teeth dental problems: Loose teeth 1.7 2.0 4.1 -1.1 -0.8 -2.0
Emphysema/chronic bronchitis 2.0 2.3 3.5 -1.9 1.7 0.6
Medication for pain relief, constipation, heartburn 1.1 2.0 3.5 1.5 -0.2 -1.9
Neck or shoulder pain in last month 3.1 4.4 9.3 -3.1 1.0 -1.7
Medication: Blood pressure 1.0 1.7 2.3 1.5 -0.8 1.5
Angina (self-reported) 0.8 1.0 2.5 -1.6 0.5 0.5
Migraine (self-reported) 0.1 0.1 0.2 -0.5 0.1 -0.1
Medication: Ibuprofen 1.1 1.3 2.3 -1.3 -0.3 1.5
Medication: Allopurinol 0.4 0.6 0.8 -0.5 -0.9 -0.9
Medication: Omeprazole 2.3 2.7 3.7 -1.9 -1.8 -1.1
Medication: Seretide 50 evohaler 0.7 0.8 2.0 0.1 -1.4 -0.7
Mean time to correctly identify matches 0.6 1.1 3.1 0.4 -1.8 -0.1
Heart disease (mother) 0.9 1.1 2.1 1.4 -0.1 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 0.3 0.4 -0.1
Whole body fat mass 1.8 7.5 14.9 -3.9 2.7 -0.6
Leg fat mass (right) 1.6 6.1 12.7 -3.6 2.3 -0.6
Arm predicted mass (right) 0.1 0.4 0.6 0.4 -0.8 -0.6
Pulse rate, automated reading 0.4 1.3 2.1 0.6 1.5 -1.2
Alcohol intake frequency. 2.2 5.1 11.1 -3.3 1.9 -0.8
Comparative height size at age 10 1.2 6.7 13.9 2.5 -3.7 0.0
Number of full sisters 0.3 0.3 0.7 0.0 0.5 0.9
Suffer from ‘nerves’ 0.2 0.3 0.7 0.4 -0.8 -0.2
Overall health rating 3.3 7.2 16.5 -4.1 2.0 1.0
Chest pain or discomfort 2.9 4.1 5.9 -2.1 2.4 1.4
Had major operations 0.2 0.2 0.4 -0.6 -0.4 0.1
Age at last live birth 1.2 1.7 3.3 1.0 -0.9 -1.8
Family relationship satisfaction 0.6 0.8 2.2 0.4 0.1 1.5
Leg pain on walking 5.0 6.2 12.7 -3.6 2.2 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.3 -0.0 -0.1 -1.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.1 0.3 -0.4 -1.5
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.4 1.2 0.2 -0.4
Medication: Aspirin 1.2 1.6 3.4 1.1 0.2 1.8
Supplements: Vitamin C 0.7 0.9 2.2 -0.4 0.5 -1.5
Knee pain experienced in last month 2.5 3.8 8.2 -2.9 1.6 -0.7
Hypertension (Self-reported) 3.3 9.2 14.5 3.8 -1.0 3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.4 2.8 5.4 -2.3 1.7 -0.4
Illnesses of father: Heart disease 0.5 0.7 1.7 0.6 -1.3 -0.1
Illnesses of siblings: Diabetes 4.5 5.5 14.1 -3.8 1.5 0.4
Smoking status: Previous 0.8 1.3 1.5 -1.0 -1.2 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.5 -0.2 -1.2 0.5
Whole body fat-free mass 0.2 1.3 3.0 -0.3 -1.7 -0.9
Leg fat-free mass (right) 0.1 0.7 1.7 -1.3 -0.0 -0.7
Arm fat percentage (left) 3.2 12.9 21.7 -4.7 4.0 -0.8
Average weekly red wine intake 0.0 0.0 0.1 -0.3 -0.1 0.0
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.9 0.9 -0.8 0.3
Mood swings 1.9 3.5 5.4 -2.3 -1.4 -1.7
Loneliness, isolation 0.5 0.7 1.4 0.4 1.2 0.8
Long-standing illness, disability or infirmity 2.4 3.7 10.6 -3.3 0.4 -0.6
Ever had bowel cancer screening 0.6 0.7 2.2 -0.0 -1.5 -0.2
Diabetes diagnosed by doctor 1.8 2.9 8.3 -2.9 0.7 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 -0.2 -0.8 0.3
Friendships satisfaction 1.1 1.3 1.5 -1.0 1.2 1.2
Qualifications: nursing, teaching 0.8 1.2 3.5 0.4 -1.9 -0.3
Commuting to job workplace: Walk 0.1 0.1 0.1 0.2 -0.4 -0.2
Eye problems/disorders: Cataract 0.2 0.2 0.4 0.6 -0.1 0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 -0.7 -0.6 -0.1
Medication for cholesterol 4.9 7.5 9.5 -2.9 2.2 -3.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.4 -0.6 1.2 -0.2
Back pain experienced in last month 3.0 4.4 11.4 -3.4 0.6 -1.2
Mineral and other dietary supplements 0.4 0.5 1.6 1.3 0.0 0.1
Breast cancer (self-reported) 2.1 2.5 7.1 -0.2 -0.5 -2.7
Asthma (self-reported) 1.1 2.2 3.3 -1.8 -1.8 0.2
Osteoporosis (self-reported) 0.2 0.2 0.3 -0.5 0.6 -0.1
Osteoarthritis (self-reported) 4.2 5.4 12.0 -3.5 2.1 -0.3
Medication: Aspirin 1.6 2.1 4.7 1.1 0.6 2.2
Medication: Gliclazide 0.6 0.7 2.0 -1.4 0.2 0.4
Illnesses of father: None of the above (group 1) 1.5 1.8 2.8 -1.6 1.7 -0.4
Smoking status: Current 1.5 2.4 3.5 -1.9 -1.6 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.0 1.2 1.4 0.6
Whole body water mass 0.2 1.0 2.2 -0.4 -1.5 -0.8
Leg predicted mass (right) 0.1 0.6 1.4 -1.2 0.0 -0.7
Arm fat mass (left) 2.2 9.1 17.1 -4.1 3.0 -1.0
Number of self-reported non-cancer illnesses 2.3 4.0 11.3 -3.4 0.8 0.4
Average weekly champagne plus white wine intake 1.0 1.4 1.6 1.3 1.1 1.2
Miserableness 0.6 1.0 2.6 -1.6 0.4 -0.3
Guilty feelings 0.1 0.1 0.2 -0.3 0.1 0.4
Wears glasses or contact lenses 0.2 0.2 0.5 0.7 -0.1 0.2
Ever taken oral contraceptive pill 0.9 1.0 2.0 0.5 0.9 1.4
Hearing aid user 0.9 1.0 2.2 0.8 -1.5 -0.1
Mother’s age at death 1.8 2.3 5.7 2.4 -1.0 0.2
Financial situation satisfaction 0.4 0.4 0.8 -0.6 0.9 -0.3
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.5 0.5 -0.6 -0.7
Commuting to job workplace: Public transport 0.1 0.1 0.3 -0.0 -0.4 0.5
Eye problems/disorders: Glaucoma 1.5 1.8 5.4 0.2 0.2 -2.3
Medication: Blood pressure 7.4 14.1 23.1 4.8 -2.1 3.9
Pain type(s) experienced in last month: Hip pain 1.6 2.0 3.4 -1.9 -0.4 -1.5
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.0 -1.4 -0.3 0.5
High cholesterol (Self-reported) 0.4 0.8 1.4 -0.5 0.8 1.2
Medication: Bendroflumethiazide 1.5 2.3 2.8 1.6 -1.7 1.3
Medication: Paracetamol 0.7 1.2 1.9 -1.2 -1.4 -0.3
Medication: Lisinopril 2.7 3.5 4.6 1.9 -1.5 2.1
Medication: Atorvastatin 0.4 0.5 0.9 -0.9 0.6 0.6
Illnesses of father: High blood pressure 2.9 3.6 9.2 3.0 -0.1 1.2
Alcohol drinker status: Never 1.0 1.2 2.3 0.9 1.5 0.7
Ever smoked 2.4 4.3 9.6 -0.7 -3.1 -1.6
Basal metabolic rate 0.1 0.8 1.1 -1.1 -0.9 -0.7
Leg fat percentage (left) 1.6 5.7 11.1 -3.3 2.4 -0.6
Arm fat-free mass (left) 0.1 0.4 0.9 -0.5 -0.9 -0.5
Number of operations (self-reported) 1.1 1.7 3.9 -2.0 0.0 -1.0
Average weekly beer plus cider intake 0.8 1.1 2.0 0.3 -1.1 1.4
Irritability 0.1 0.2 0.3 0.4 -0.5 0.1
Risk taking 0.7 1.1 2.3 -1.5 -0.7 0.6
Ever had prostate specific antigen (PSA) test 0.7 0.9 2.0 0.5 -1.4 0.6
Fractured/broken bones in last 5 years 1.6 2.1 3.8 0.7 -1.4 -2.0
Age started oral contraceptive pill 2.2 2.7 7.4 2.7 0.6 0.7
Diastolic blood pressure, automated reading 1.6 5.1 10.3 3.2 -1.5 1.6
Ever depressed for a whole week 0.4 0.5 1.2 -0.2 1.1 -0.4
Unable to work because of sickness or disability 0.5 0.6 1.3 -1.1 0.4 -0.7
Commuting to job workplace: Cycle 1.0 1.2 3.1 1.8 0.1 0.8
Myopia 3.3 4.8 7.2 1.2 -2.7 -2.4
Vascular/heart problems diagnosed by doctor 2.6 7.2 11.1 -3.3 1.2 -3.0
Cholesterol lowering medication 0.2 0.3 0.7 0.2 -0.3 0.9
Medication: Omeprazole (e.g. Zanprol) 2.1 2.5 5.6 -2.4 -0.8 -1.2
Pain experienced in last month 3.2 5.3 11.7 3.4 -0.5 2.0
Supplements: Calcium 2.4 2.7 5.4 -1.4 0.7 -2.3
Basal cell carcinoma (self-reported) 3.0 3.6 6.4 2.5 1.1 1.7
Heart attack/myocardial infarction (self-reported) 0.3 0.3 0.5 -0.7 -0.4 0.5
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 3.7 -0.2 1.3 -1.9
Heart disease (siblings) 0.7 0.8 2.3 0.2 -1.5 -0.4
Alcohol drinker status: Previous 3.6 4.1 11.8 -3.4 0.4 -0.6
Pack years of smoking 1.2 1.8 4.7 -2.2 0.7 -0.1
Impedance of whole body 0.2 1.1 2.9 0.5 0.3 1.7
Leg fat mass (left) 1.5 5.7 11.8 -3.4 2.3 -0.5
Arm predicted mass (left) 0.1 0.5 1.2 -0.2 -1.1 -0.6