Hub : Genes

CPNE7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.092	0.0310	3.4e-07	0.016	0.039	0.030	0.039	0.023	0.0039	1.4e-05	0.00013	1.4e-05	0.00067
2	METSIM	Adipose	0.089	0.0277	1.4e-07	0.009	0.050	0.021	0.047	0.017	0.0160	4.5e-08	0.00029	1.4e-07	0.00110
3	TCGA	Thyroid Carcinoma	0.063	0.0300	7.3e-03	0.013	0.018	0.008	NA	0.026	0.0160	7.0e-03	0.05000	NA	0.00130

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.3	3.7	9.6	-3.1	0.1	-1.2
Bipolar Disorder or Schizophrenia	4.5	11.0	29.1	-5.4	-0.3	-1.9
Depressed Affect (Nagel 2018)	0.3	0.6	0.9	-0.6	-0.9	0.7
Depression (Nagel 2018)	0.4	0.7	1.0	0.6	-1.0	0.8
Intelligence (Savage-Jansen 2018)	1.4	4.4	7.6	2.3	-2.8	0.4
Neuroticism (Nagel 2018)	0.3	0.6	0.8	0.6	-0.8	0.9
Schizophrenia (2018)	3.5	7.2	19.2	-4.4	-0.5	-1.5
Schizophrenia vs Biploar Disorder	1.1	1.5	2.6	-1.6	1.4	0.1
Worry (Nagel 2018)	0.3	0.6	0.9	0.8	-1.0	0.4
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	-0.7	0.3	-0.6
Alzheimer’s Disease (in father)	0.9	1.0	1.7	-0.3	-1.0	-1.3
Alzheimer’s Disease (including proxy)	0.7	1.1	1.8	-1.0	-0.6	-1.3
Crohns Disease (2017)	0.2	0.4	0.8	-0.2	-0.6	0.9
Irritable Bowel Disease (IBD)	0.2	0.4	0.8	-0.2	-0.9	-0.5
Ulcerative Colitis (UC)	0.3	0.6	1.3	0.1	-0.8	-1.1
Major Depression (MDD)	3.5	4.3	9.8	-1.8	3.1	0.0
Reaction Time	0.0	0.1	0.1	-0.3	-0.3	0.0
Verbal and Numeric Reasoning (VNR)	2.0	4.7	7.9	2.8	-2.4	0.8
Breast Cancer	3.2	7.6	16.8	1.0	-4.1	-2.2
Ovarian Cancer	0.8	1.1	2.2	0.8	-1.5	-0.6
Prostate Cancer	0.9	1.2	2.6	-0.8	1.6	0.6
Age at First Birth	0.6	0.9	2.3	1.5	-0.6	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	1.6	-1.3	1.0	-0.1
Coronary Artery Disease (CAD)	4.4	5.2	12.0	-0.4	-3.5	-1.9
Crohns Disease (2012)	0.0	0.1	0.2	0.5	0.0	0.0
Mean Putamen Volume	0.9	1.0	1.6	-1.2	-1.2	-0.4
Fasting Glucose	1.8	2.1	3.3	-1.8	0.9	-1.5
HbA1C	2.0	2.3	6.6	-2.6	0.2	-0.4
HDL Cholesterol	0.9	1.6	3.2	1.8	-1.1	0.6
LDL Cholesterol	0.9	1.4	2.3	-1.5	1.4	-0.3
Lupus	0.7	1.1	3.0	-1.7	0.5	0.2
Neuroticism (2016)	0.5	0.7	1.2	1.1	0.2	1.0
Primary Biliary Cirrhosis	0.9	1.3	3.2	-0.5	1.8	0.7
Rheumatoid Arthritis	2.1	2.9	6.0	-2.5	1.2	1.1
Schizophrenia (2014)	5.2	11.6	32.0	-5.7	1.1	-1.2
Triglycerides	2.7	4.4	9.6	-3.1	1.5	-1.1
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.2	-1.5	0.5	-0.7
Ulcerative Colitis	0.4	0.5	1.0	0.8	-1.0	0.0
Blood Eosinophil Count	0.1	0.4	1.2	0.1	0.2	1.1
Blood Platelet Count	0.1	1.2	2.3	1.2	0.2	1.5
Blood Red Count	0.3	3.0	7.7	0.7	2.8	-0.9
Blood White Count	0.6	4.8	14.2	0.1	0.3	-3.8
Heel T-Score	0.0	0.4	0.4	0.6	0.7	0.5
BMI	2.5	14.7	22.6	-4.8	4.5	-1.1
Height	0.8	15.5	33.3	3.3	-5.8	-1.6
Waist Hip Ratio (WHR)	0.3	1.1	2.7	-0.8	-1.6	-0.3
Systolic Blood Pressure	0.5	2.5	6.0	1.1	-2.5	0.6
Smoking Status	2.4	5.7	9.2	-3.0	-2.0	-2.0
Allergy or Eczema	0.7	1.8	2.5	-1.6	1.3	1.1
Cardiovascular Disease	2.6	8.5	16.4	3.0	-0.1	4.0
Hypothyroidism (self reported)	0.3	0.8	1.2	-1.1	1.0	-0.4
Respiratory disease	1.1	2.4	5.0	-2.2	-1.4	0.5
Type 2 Diabetes (T2D) (2018)	1.6	3.0	8.3	-2.9	0.8	-0.2
Lung FEV1/FVC ratio	0.2	1.0	1.3	1.1	1.0	0.8
Lung FVC	1.5	7.6	21.2	4.6	-1.2	-0.6
Neuroticism	0.3	0.8	1.4	-0.9	-0.5	1.2
Chronotype (morning person)	0.7	1.5	3.4	0.2	-1.1	-1.9
Hair Pigment	31.3	891.5	1584.0	39.8	-1.2	33.0
Tanning	57.3	699.0	1310.4	-36.2	-14.0	-24.3
Hand grip strength (left)	1.8	4.9	9.6	3.1	-2.1	0.8
Number of treatments/medications taken	1.0	1.8	3.0	-1.7	-1.1	1.1
Average weekly spirits intake	0.7	0.8	2.4	1.6	-0.2	0.1
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.5	-0.1	-0.5
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.1	0.4	0.2
Hearing difficulty/problems: Yes	0.6	0.9	1.3	-1.2	-0.8	0.9
Relative age of first facial hair	0.9	1.9	3.0	1.0	-1.7	1.2
Other serious medical condition/disability diagnosed by doctor	5.0	6.4	8.1	-2.8	-1.8	-2.9
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.7	0.1	-1.9	-0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.2	-0.4	-0.5	0.3
Systolic blood pressure, automated reading	0.3	0.9	2.2	0.4	-1.5	-0.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.8	-0.1	0.4	-1.3
Angina	0.7	0.9	2.5	-1.6	0.3	0.2
Medication for hormone replacement therapy	0.5	0.6	1.3	-0.2	-0.6	1.1
Vitamin and mineral supplements	0.7	1.0	2.4	1.6	-0.3	0.7
Supplements: Zinc	0.4	0.5	1.2	0.1	-0.4	-1.1
Medication: Co-codamol	0.9	1.0	2.0	-0.5	-1.4	-0.9
Medication: Metformin	0.2	0.3	0.7	-0.6	0.8	-0.0
Diabetes (father)	1.5	1.9	3.3	-1.8	0.3	-1.5
Diabetes (mother)	2.5	3.1	9.1	-3.0	0.4	0.3
Severe depression (siblings)	2.7	3.0	4.8	-2.2	-0.1	-2.1
Pack years adult smoking proportion	1.7	2.7	6.6	-2.6	1.2	0.1
Impedance of leg (right)	0.3	1.7	2.7	1.1	-1.1	1.6
Leg fat-free mass (left)	0.2	1.1	2.7	-1.6	0.1	-0.8
Trunk fat percentage	3.1	12.3	19.6	-4.4	4.1	-0.1
Hand grip strength (right)	1.4	3.9	8.4	2.9	-1.8	0.3
Townsend deprivation index at recruitment	2.9	4.0	5.8	-2.4	2.3	1.1
Current tobacco smoking	0.9	1.5	2.5	-1.6	-0.9	-1.1
Average weekly fortified wine intake	2.0	2.4	3.5	1.9	-1.8	-0.7
Maternal smoking around birth	1.3	1.9	3.1	-1.6	1.8	0.0
Fed-up feelings	0.6	1.1	2.8	-1.7	0.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.1	0.0	0.0
Relative age voice broke	0.3	0.5	1.1	-0.5	-0.1	1.0
Taking other prescription medications	3.7	5.8	17.0	-4.1	0.4	-0.5
Age when periods started (menarche)	0.2	0.4	1.1	-0.1	1.1	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.4	-0.3	-0.6	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.8	-1.0	0.3	-1.7
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.7	0.2	1.3	1.0
Qualifications: CSEs or equivalent	1.9	2.5	5.3	-1.3	2.3	-0.6
Serious illness, injury or assault to yourself	1.5	1.8	3.6	-0.2	-1.3	-1.9
High blood pressure	3.1	8.7	13.7	3.7	-1.5	3.2
Hayfever, allergic rhinitis or eczema	0.6	1.2	1.7	-1.2	0.7	1.3
Multivitamins +/- minerals	0.3	0.4	0.8	-0.9	-0.4	0.3
Stomach or abdominal pain in last month	2.9	3.6	8.5	-2.9	0.7	-1.3
Supplements: Glucosamine	0.1	0.2	0.4	-0.7	-0.3	-0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.4	-0.1	-0.7
Medication: Atenolol	3.4	4.3	7.1	2.4	-2.7	-0.0
Medication: Levothyroxine sodium	0.9	1.5	3.9	-2.0	0.1	-0.7
Sitting height	0.6	3.9	10.5	0.7	-3.2	-0.9
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	-1.1	0.3	0.4
High blood pressure (mother)	2.2	3.1	8.1	2.8	-0.3	1.0
Body mass index (BMI)	2.0	8.5	14.7	-3.8	3.0	-1.3
Impedance of leg (left)	0.4	2.2	3.4	1.5	-1.0	1.8
Leg predicted mass (left)	0.2	1.1	2.6	-1.6	0.0	-0.8
Trunk fat mass	1.8	7.9	15.6	-4.0	2.8	-0.4
Waist circumference	1.5	5.6	14.1	-3.8	1.7	-0.0
Number of incorrect matches in round	1.5	2.4	4.9	-1.1	-1.1	-2.2
Past tobacco smoking	2.2	4.1	5.6	1.8	2.4	1.8
Alcohol usually taken with meals	0.0	0.0	0.1	-0.2	0.3	-0.2
Nervous feelings	0.2	0.4	0.7	0.2	-0.7	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	2.5	-1.2	0.1	-1.6
Hearing difficulty/problems with background noise	0.8	1.3	2.8	-1.0	-1.7	0.4
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	0.5	0.5	1.0
Had menopause	6.1	7.6	18.8	1.9	-4.3	-0.4
Had other major operations	2.3	2.8	4.7	-1.8	2.2	-0.6
Forced vital capacity (FVC)	1.5	6.0	14.7	3.8	-1.7	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	0.0	0.6	-1.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.6	-0.2	-0.9	-1.9
Qualifications: None of the above	0.3	0.6	1.7	-0.4	0.1	-1.3
Financial difficulties in last 2 years	1.1	1.5	2.8	-0.7	1.7	1.1
Mouth/teeth dental problems	2.3	3.5	7.6	2.8	-1.5	-0.9
Heart attack	0.2	0.3	0.4	-0.7	-0.6	0.1
Allergy	1.0	2.3	5.7	2.4	-1.0	-0.5
Pain all over the body in last month	1.1	1.2	2.0	-1.4	1.2	0.4
Diabetes (self-reported)	2.2	3.4	9.9	-3.1	0.5	0.1
Hayfever/allergic rhinitis (self-reported)	3.1	4.2	5.2	-2.0	1.8	2.3
Medication: Ramipril	0.5	0.7	1.9	0.2	-0.3	1.4
Medication: Simvastatin	0.2	0.3	0.3	-0.5	0.5	0.6
Fluid intelligence score	1.4	3.0	4.3	2.1	-2.0	0.7
Illnesses of siblings	0.7	0.9	1.7	-0.1	1.3	1.1
Neuroticism score	0.1	0.1	0.4	-0.6	-0.0	-0.1
Weight	0.6	2.9	7.1	-2.7	1.1	-0.5
Impedance of arm (right)	0.2	0.9	1.9	-1.4	-0.1	0.9
Arm fat percentage (right)	3.5	13.6	26.7	-5.2	3.7	-0.7
Trunk fat-free mass	0.5	2.8	7.8	0.2	-2.8	-0.8
Hip circumference	0.5	2.1	4.6	-2.1	1.3	0.2
Time employed in main current job	1.3	1.5	3.2	-1.1	-1.8	-0.2
Alcohol intake versus 10 years previously	2.1	3.1	6.4	-2.5	-0.4	-1.6
Father’s age at death	0.9	1.2	2.3	-1.1	-0.6	-1.5
Worrier / anxious feelings	0.7	1.4	2.7	0.1	-1.2	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	5.6	-2.4	0.1	-1.4
Falls in the last year	1.3	1.8	2.7	-1.7	1.3	-1.0
Hair/balding pattern: Pattern 3	1.0	1.5	2.1	1.1	1.5	1.1
Number of live births	4.6	6.5	15.0	-0.8	-3.9	-2.0
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	15.2	3.9	-1.0	-0.1
Pulse rate	1.0	1.7	3.0	0.4	1.7	-1.4
Happiness	0.2	0.3	0.6	-0.8	0.4	0.3
Noisy workplace	0.4	0.5	0.7	-0.8	-0.8	0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	1.8	1.4	-1.1	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	-0.4	-1.0	0.0
Mouth/teeth dental problems: Dentures	2.1	3.6	8.4	-2.9	1.5	-0.1
Asthma	1.2	2.4	4.0	-2.0	-1.8	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.9	-1.0	0.0	2.0
Medication: Cholesterol lowering	0.7	1.1	2.1	-1.0	1.4	0.5
Depression (self-reported)	1.2	1.4	1.9	-1.4	-0.8	-1.3
Medication: Lansoprazole	5.7	6.5	9.7	-3.1	3.1	0.6
Prospective memory result	1.3	1.6	4.3	-0.1	0.7	2.1
Lung cancer (father)	0.1	0.1	0.2	-0.5	0.2	0.2
Illnesses of mother	0.8	1.0	2.4	-0.7	-0.2	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	13.1	3.6	-1.2	-0.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	0.2	-0.1	-0.6
Impedance of arm (left)	0.2	0.8	1.8	-0.2	0.8	1.4
Arm fat mass (right)	2.2	9.2	19.2	-4.4	2.8	-0.8
Trunk predicted mass	0.6	3.2	8.7	0.3	-3.0	-1.0
Standing height	0.8	8.1	18.4	2.1	-4.3	1.3
Length of working week for main job	1.5	1.6	4.0	-0.2	2.0	-0.9
Exposure to tobacco smoke at home	0.4	0.5	0.8	-0.5	0.9	-0.7
Breastfed as a baby	1.1	1.4	1.6	-1.1	1.3	-1.1
Tense / ‘highly strung’	0.3	0.6	1.0	0.7	-0.3	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	4.5	-2.1	0.9	-1.5
Hair/balding pattern: Pattern 4	1.3	3.2	9.2	3.0	0.3	0.6
Birth weight of first child	1.5	2.7	7.7	0.2	-2.8	0.5
Peak expiratory flow (PEF)	1.8	4.3	11.6	3.4	-1.0	-0.3
Pulse wave reflection index	1.4	1.8	3.3	1.4	-1.8	0.2
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.2	-0.2	0.2	1.1
Loud music exposure frequency	0.9	0.9	1.2	-1.1	-1.1	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.6	0.0	0.0	1.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	-0.1	0.7	1.0
Blood clot in the leg (DVT)	1.8	2.3	4.4	-0.2	1.6	-2.1
Medication: Paracetamol	0.7	1.2	2.2	-1.0	-1.5	0.6
Headache pain in last month	0.9	1.5	3.9	-0.8	-2.0	-0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.9	0.1	-0.8	-1.4
Glaucoma (self-reported)	1.0	1.2	3.3	0.1	0.5	-1.8
Gout (self-reported)	0.3	0.5	0.8	-0.9	0.5	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.7	-1.3	0.4	-0.8
Medication: Amlodipine	2.2	3.1	6.6	2.6	-1.1	1.3
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.7	-1.9	-0.9	-0.4
Birth weight	2.3	5.0	13.2	0.1	-3.6	-1.3
Chronic bronchitis/emphysema (mother)	2.1	2.4	6.6	-2.6	-0.7	-0.3
High blood pressure (siblings)	0.9	1.2	1.9	1.4	-1.3	-0.3
Forced vital capacity (FVC), Best measure	1.4	5.3	11.2	3.4	-2.1	-0.2
Body fat percentage	2.8	11.2	18.9	-4.3	3.8	-0.3
Leg fat percentage (right)	1.7	6.2	12.7	-3.6	2.3	-0.7
Arm fat-free mass (right)	0.1	0.5	0.8	0.7	-0.9	-0.4
Exposure to tobacco smoke outside home	1.7	2.2	4.0	-2.0	1.6	-0.3
Comparative body size at age 10	0.9	2.4	7.0	0.2	0.3	-2.6
Number of full brothers	1.4	1.7	2.5	-1.5	0.7	1.6
Worry too long after embarrassment	1.1	1.8	5.1	0.5	2.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.0	-0.9	0.4	-1.0
Wheeze or whistling in the chest in last year	1.4	2.6	7.6	-2.8	0.1	-0.3
Number of children fathered	3.5	3.9	11.4	-0.5	-3.4	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.0	-1.7	-0.8	0.0
Age at first live birth	1.4	2.4	4.3	2.1	-1.2	-1.2
Pulse wave peak to peak time	0.1	0.1	0.4	-0.0	-0.2	0.6
Health satisfaction	3.3	4.2	9.2	-3.0	1.9	-0.0
Shortness of breath walking on level ground	2.6	3.0	6.0	-2.4	1.7	0.4
Qualifications: College or University degree	1.1	3.6	5.7	2.2	-2.4	-0.3
Eye problems/disorders: None of the above	0.4	0.5	1.0	0.8	-1.0	0.1
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.1	-1.1	-0.8	-2.0
Emphysema/chronic bronchitis	2.0	2.3	3.5	-1.9	1.7	0.6
Medication for pain relief, constipation, heartburn	1.1	2.0	3.5	1.5	-0.2	-1.9
Neck or shoulder pain in last month	3.1	4.4	9.3	-3.1	1.0	-1.7
Medication: Blood pressure	1.0	1.7	2.3	1.5	-0.8	1.5
Angina (self-reported)	0.8	1.0	2.5	-1.6	0.5	0.5
Migraine (self-reported)	0.1	0.1	0.2	-0.5	0.1	-0.1
Medication: Ibuprofen	1.1	1.3	2.3	-1.3	-0.3	1.5
Medication: Allopurinol	0.4	0.6	0.8	-0.5	-0.9	-0.9
Medication: Omeprazole	2.3	2.7	3.7	-1.9	-1.8	-1.1
Medication: Seretide 50 evohaler	0.7	0.8	2.0	0.1	-1.4	-0.7
Mean time to correctly identify matches	0.6	1.1	3.1	0.4	-1.8	-0.1
Heart disease (mother)	0.9	1.1	2.1	1.4	-0.1	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	0.3	0.4	-0.1
Whole body fat mass	1.8	7.5	14.9	-3.9	2.7	-0.6
Leg fat mass (right)	1.6	6.1	12.7	-3.6	2.3	-0.6
Arm predicted mass (right)	0.1	0.4	0.6	0.4	-0.8	-0.6
Pulse rate, automated reading	0.4	1.3	2.1	0.6	1.5	-1.2
Alcohol intake frequency.	2.2	5.1	11.1	-3.3	1.9	-0.8
Comparative height size at age 10	1.2	6.7	13.9	2.5	-3.7	0.0
Number of full sisters	0.3	0.3	0.7	0.0	0.5	0.9
Suffer from ‘nerves’	0.2	0.3	0.7	0.4	-0.8	-0.2
Overall health rating	3.3	7.2	16.5	-4.1	2.0	1.0
Chest pain or discomfort	2.9	4.1	5.9	-2.1	2.4	1.4
Had major operations	0.2	0.2	0.4	-0.6	-0.4	0.1
Age at last live birth	1.2	1.7	3.3	1.0	-0.9	-1.8
Family relationship satisfaction	0.6	0.8	2.2	0.4	0.1	1.5
Leg pain on walking	5.0	6.2	12.7	-3.6	2.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.3	-0.0	-0.1	-1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	0.3	-0.4	-1.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	1.2	0.2	-0.4
Medication: Aspirin	1.2	1.6	3.4	1.1	0.2	1.8
Supplements: Vitamin C	0.7	0.9	2.2	-0.4	0.5	-1.5
Knee pain experienced in last month	2.5	3.8	8.2	-2.9	1.6	-0.7
Hypertension (Self-reported)	3.3	9.2	14.5	3.8	-1.0	3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	5.4	-2.3	1.7	-0.4
Illnesses of father: Heart disease	0.5	0.7	1.7	0.6	-1.3	-0.1
Illnesses of siblings: Diabetes	4.5	5.5	14.1	-3.8	1.5	0.4
Smoking status: Previous	0.8	1.3	1.5	-1.0	-1.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.5	-0.2	-1.2	0.5
Whole body fat-free mass	0.2	1.3	3.0	-0.3	-1.7	-0.9
Leg fat-free mass (right)	0.1	0.7	1.7	-1.3	-0.0	-0.7
Arm fat percentage (left)	3.2	12.9	21.7	-4.7	4.0	-0.8
Average weekly red wine intake	0.0	0.0	0.1	-0.3	-0.1	0.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.9	0.9	-0.8	0.3
Mood swings	1.9	3.5	5.4	-2.3	-1.4	-1.7
Loneliness, isolation	0.5	0.7	1.4	0.4	1.2	0.8
Long-standing illness, disability or infirmity	2.4	3.7	10.6	-3.3	0.4	-0.6
Ever had bowel cancer screening	0.6	0.7	2.2	-0.0	-1.5	-0.2
Diabetes diagnosed by doctor	1.8	2.9	8.3	-2.9	0.7	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.2	-0.8	0.3
Friendships satisfaction	1.1	1.3	1.5	-1.0	1.2	1.2
Qualifications: nursing, teaching	0.8	1.2	3.5	0.4	-1.9	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.1	0.2	-0.4	-0.2
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.6	-0.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	-0.7	-0.6	-0.1
Medication for cholesterol	4.9	7.5	9.5	-2.9	2.2	-3.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	-0.6	1.2	-0.2
Back pain experienced in last month	3.0	4.4	11.4	-3.4	0.6	-1.2
Mineral and other dietary supplements	0.4	0.5	1.6	1.3	0.0	0.1
Breast cancer (self-reported)	2.1	2.5	7.1	-0.2	-0.5	-2.7
Asthma (self-reported)	1.1	2.2	3.3	-1.8	-1.8	0.2
Osteoporosis (self-reported)	0.2	0.2	0.3	-0.5	0.6	-0.1
Osteoarthritis (self-reported)	4.2	5.4	12.0	-3.5	2.1	-0.3
Medication: Aspirin	1.6	2.1	4.7	1.1	0.6	2.2
Medication: Gliclazide	0.6	0.7	2.0	-1.4	0.2	0.4
Illnesses of father: None of the above (group 1)	1.5	1.8	2.8	-1.6	1.7	-0.4
Smoking status: Current	1.5	2.4	3.5	-1.9	-1.6	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.0	1.2	1.4	0.6
Whole body water mass	0.2	1.0	2.2	-0.4	-1.5	-0.8
Leg predicted mass (right)	0.1	0.6	1.4	-1.2	0.0	-0.7
Arm fat mass (left)	2.2	9.1	17.1	-4.1	3.0	-1.0
Number of self-reported non-cancer illnesses	2.3	4.0	11.3	-3.4	0.8	0.4
Average weekly champagne plus white wine intake	1.0	1.4	1.6	1.3	1.1	1.2
Miserableness	0.6	1.0	2.6	-1.6	0.4	-0.3
Guilty feelings	0.1	0.1	0.2	-0.3	0.1	0.4
Wears glasses or contact lenses	0.2	0.2	0.5	0.7	-0.1	0.2
Ever taken oral contraceptive pill	0.9	1.0	2.0	0.5	0.9	1.4
Hearing aid user	0.9	1.0	2.2	0.8	-1.5	-0.1
Mother’s age at death	1.8	2.3	5.7	2.4	-1.0	0.2
Financial situation satisfaction	0.4	0.4	0.8	-0.6	0.9	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	0.5	-0.6	-0.7
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.0	-0.4	0.5
Eye problems/disorders: Glaucoma	1.5	1.8	5.4	0.2	0.2	-2.3
Medication: Blood pressure	7.4	14.1	23.1	4.8	-2.1	3.9
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.4	-1.9	-0.4	-1.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.0	-1.4	-0.3	0.5
High cholesterol (Self-reported)	0.4	0.8	1.4	-0.5	0.8	1.2
Medication: Bendroflumethiazide	1.5	2.3	2.8	1.6	-1.7	1.3
Medication: Paracetamol	0.7	1.2	1.9	-1.2	-1.4	-0.3
Medication: Lisinopril	2.7	3.5	4.6	1.9	-1.5	2.1
Medication: Atorvastatin	0.4	0.5	0.9	-0.9	0.6	0.6
Illnesses of father: High blood pressure	2.9	3.6	9.2	3.0	-0.1	1.2
Alcohol drinker status: Never	1.0	1.2	2.3	0.9	1.5	0.7
Ever smoked	2.4	4.3	9.6	-0.7	-3.1	-1.6
Basal metabolic rate	0.1	0.8	1.1	-1.1	-0.9	-0.7
Leg fat percentage (left)	1.6	5.7	11.1	-3.3	2.4	-0.6
Arm fat-free mass (left)	0.1	0.4	0.9	-0.5	-0.9	-0.5
Number of operations (self-reported)	1.1	1.7	3.9	-2.0	0.0	-1.0
Average weekly beer plus cider intake	0.8	1.1	2.0	0.3	-1.1	1.4
Irritability	0.1	0.2	0.3	0.4	-0.5	0.1
Risk taking	0.7	1.1	2.3	-1.5	-0.7	0.6
Ever had prostate specific antigen (PSA) test	0.7	0.9	2.0	0.5	-1.4	0.6
Fractured/broken bones in last 5 years	1.6	2.1	3.8	0.7	-1.4	-2.0
Age started oral contraceptive pill	2.2	2.7	7.4	2.7	0.6	0.7
Diastolic blood pressure, automated reading	1.6	5.1	10.3	3.2	-1.5	1.6
Ever depressed for a whole week	0.4	0.5	1.2	-0.2	1.1	-0.4
Unable to work because of sickness or disability	0.5	0.6	1.3	-1.1	0.4	-0.7
Commuting to job workplace: Cycle	1.0	1.2	3.1	1.8	0.1	0.8
Myopia	3.3	4.8	7.2	1.2	-2.7	-2.4
Vascular/heart problems diagnosed by doctor	2.6	7.2	11.1	-3.3	1.2	-3.0
Cholesterol lowering medication	0.2	0.3	0.7	0.2	-0.3	0.9
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	5.6	-2.4	-0.8	-1.2
Pain experienced in last month	3.2	5.3	11.7	3.4	-0.5	2.0
Supplements: Calcium	2.4	2.7	5.4	-1.4	0.7	-2.3
Basal cell carcinoma (self-reported)	3.0	3.6	6.4	2.5	1.1	1.7
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.5	-0.7	-0.4	0.5
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.7	-0.2	1.3	-1.9
Heart disease (siblings)	0.7	0.8	2.3	0.2	-1.5	-0.4
Alcohol drinker status: Previous	3.6	4.1	11.8	-3.4	0.4	-0.6
Pack years of smoking	1.2	1.8	4.7	-2.2	0.7	-0.1
Impedance of whole body	0.2	1.1	2.9	0.5	0.3	1.7
Leg fat mass (left)	1.5	5.7	11.8	-3.4	2.3	-0.5
Arm predicted mass (left)	0.1	0.5	1.2	-0.2	-1.1	-0.6