TWAS hub - CPO

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0570	0.0261	0.0094	-0.001	NA	0.005	NA	-0.002	4.3e-01	NA	0.0860	NA	0.51000
2	ROSMAP	Brain Pre-frontal Cortex	0.0439	0.0185	0.0034	0.023	0.011	0.012	0.012	0.023	4.5e-04	0.01200	0.0095	0.01	0.00051
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0720	0.0360	0.0040	0.057	0.049	0.024	NA	0.024	3.3e-04	0.00084	0.0150	NA	0.01600
4	TCGA	Lung Squamous Cell Carcinoma	0.0363	0.0200	0.0020	0.041	0.024	0.021	NA	0.029	1.6e-05	0.00086	0.0017	NA	0.00026

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4
Pain experienced in last month	5.7	9.6	31.8	5.6	2.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	4.8	7.8	25.7	-5.1	-2.3	-0.6
Overall health rating	4.4	9.5	31.7	-5.6	-2.2	1.1
Medication for pain relief, constipation, heartburn	4.3	7.3	26.1	5.1	1.7	0.3
Medication: Aspirin	3.9	5.1	17.7	-4.2	0.7	1.5
Hearing difficulty/problems: Yes	3.8	5.8	22.9	-4.8	-0.5	-0.2
Major Depression (MDD)	3.7	4.5	17.9	-4.2	0.0	0.4
Chest pain or discomfort	3.7	5.3	19.2	-4.4	-1.1	-0.9
Angina	3.4	4.4	15.2	-3.9	0.4	1.5
Medication: Paracetamol	3.4	5.6	14.7	-3.8	-2.6	-1.0
Medication: Aspirin	3.2	4.2	14.1	-3.8	0.7	1.5
Medication: Paracetamol	3.1	4.8	13.8	-3.7	-2.2	-0.8
Neuroticism (2016)	3.0	4.3	17.1	-4.1	-0.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.6	15.1	-3.9	-1.8	-0.6
Hearing difficulty/problems with background noise	3.0	4.8	18.5	-4.3	0.7	0.6
Angina (self-reported)	3.0	3.9	13.0	-3.6	0.5	1.6
Current tobacco smoking	2.9	4.7	14.0	-3.7	0.5	2.1
Frequency of depressed mood in last 2 weeks	2.7	3.8	14.8	-3.8	0.2	0.6
Back pain experienced in last month	2.7	3.9	9.3	-3.0	-1.1	2.2
Financial difficulties in last 2 years	2.6	3.5	12.5	-3.5	-1.2	-0.1
Townsend deprivation index at recruitment	2.4	3.3	9.5	-3.1	-1.9	0.5
Relative age voice broke	2.4	3.7	11.4	3.4	1.7	0.6
Body Mass Index (BMI) (2010)	2.3	3.2	6.2	1.9	-2.5	-1.7
Medication: Ventolin 100micrograms inhaler	2.3	2.9	11.5	-3.4	-0.1	-0.1
Long-standing illness, disability or infirmity	2.3	3.5	12.2	-3.5	-0.3	1.3
Smoking status: Current	2.3	3.7	10.8	-3.3	0.4	1.9
Stomach or abdominal pain in last month	2.2	2.8	5.7	-2.4	0.9	2.1
Serious illness, injury or assault to yourself	2.1	2.6	9.7	-3.1	-0.6	0.3
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	5.3	-1.8	-2.3	-1.5
Knee pain experienced in last month	2.1	3.3	8.8	-3.0	-2.0	0.5
Eye problems/disorders: Cataract	2.1	2.5	7.4	-0.1	-2.7	-1.6
Headache pain in last month	2.0	3.5	7.2	-2.6	-2.7	-0.4
Pain type(s) experienced in last month: Hip pain	2.0	2.6	9.5	-3.1	-0.0	0.9
Supplements: Fish oil (including cod liver oil)	2.0	2.6	8.6	2.9	1.4	-0.2
Basal cell carcinoma (self-reported)	2.0	2.4	6.9	0.3	1.6	2.6
Eye problems/disorders: None of the above	1.9	2.2	5.1	0.4	2.2	1.9
Leg pain on walking	1.9	2.3	8.3	-2.9	-0.0	1.0
Risk taking	1.9	2.7	9.4	-3.1	-0.6	1.1
Alzheimer’s Disease (in mother)	1.8	2.1	4.5	-0.7	1.9	2.1
Supplements: Zinc	1.8	2.0	4.4	2.1	1.2	-1.5
Maternal smoking around birth	1.8	2.5	9.8	-3.1	-0.4	0.5
Mouth/teeth dental problems	1.8	2.8	6.2	2.5	1.5	1.6
Mean time to correctly identify matches	1.8	3.4	11.9	-3.5	-1.3	-0.1
Ever had prostate specific antigen (PSA) test	1.8	2.1	6.9	-2.6	-0.3	1.2
Allergy or Eczema	1.7	4.4	11.3	-3.4	-1.8	-1.8
Diabetes (father)	1.7	2.1	6.2	0.5	-2.5	-1.4
Heart attack	1.7	2.1	5.3	-1.8	-2.3	-0.2
High blood pressure (siblings)	1.7	2.5	8.6	-2.9	-1.1	0.5
Shortness of breath walking on level ground	1.7	2.0	5.0	-2.2	-0.8	-1.5
Mineral and other dietary supplements	1.7	2.3	6.0	-2.5	-1.7	0.4
Medication: Co-codamol	1.6	1.8	6.2	-2.5	-1.0	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	7.7	-0.2	-2.8	-0.7
Neck or shoulder pain in last month	1.6	2.3	8.1	-2.8	-1.1	-0.0
Loneliness, isolation	1.6	2.3	5.4	-2.3	-1.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	11.0	3.3	-1.4	0.1
Ever smoked	1.6	2.7	10.4	-3.2	-0.4	0.5
Respiratory disease	1.5	3.4	11.9	-3.5	0.9	0.9
Ever highly irritable/argumentative for 2 days	1.5	1.8	5.6	-2.4	-0.9	-0.9
Wheeze or whistling in the chest in last year	1.5	2.6	8.1	-2.8	-1.6	0.1
Health satisfaction	1.5	1.9	6.3	-2.5	-1.2	0.2
Guilty feelings	1.5	2.3	5.5	0.2	-1.9	-2.4
Heart attack/myocardial infarction (self-reported)	1.5	2.0	5.1	-1.6	-2.2	-0.5
Smoking Status	1.4	3.4	9.7	-3.1	0.3	2.0
Neuroticism	1.4	3.4	12.0	-3.5	0.9	-0.9
Fed-up feelings	1.4	2.5	8.2	-2.9	0.1	1.4
Allergy	1.4	3.2	10.4	3.2	0.3	1.6
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	8.7	2.9	0.2	-0.5
Supplements: Vitamin C	1.4	1.7	3.4	1.8	1.9	-0.3
Miserableness	1.4	2.3	9.3	-3.1	-0.1	-0.2
Unable to work because of sickness or disability	1.4	1.8	3.1	-1.7	-1.4	1.4
Supplements: Calcium	1.4	1.5	3.2	0.2	-1.8	-1.7
Alcohol drinker status: Previous	1.4	1.6	3.0	-1.0	1.5	1.7
Depression (Nagel 2018)	1.3	2.0	7.2	-2.7	0.0	0.8
Number of treatments/medications taken	1.3	2.3	9.2	-3.0	0.3	0.3
Taking other prescription medications	1.3	2.0	6.3	-2.5	0.6	1.2
Nervous feelings	1.3	2.4	8.7	-3.0	0.8	-0.4
Asthma	1.3	2.6	9.4	-3.1	0.2	-1.0
Exposure to tobacco smoke outside home	1.3	1.8	4.0	-1.0	-1.4	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.5	-1.9	-0.3	-1.8
Medication: Ibuprofen	1.3	1.6	6.0	-0.5	-2.4	-0.2
Wears glasses or contact lenses	1.3	1.5	4.1	-1.0	1.0	2.0
Illnesses of father: High blood pressure	1.3	1.6	6.0	-2.5	-0.7	0.3
Depressed Affect (Nagel 2018)	1.2	2.5	8.8	-3.0	0.2	1.1
Lupus	1.2	1.8	5.1	2.3	0.7	1.3
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.3	-1.0	-1.0	-1.8
Impedance of leg (right)	1.2	5.7	21.8	-4.7	0.7	0.7
Hand grip strength (right)	1.2	3.2	10.2	3.2	0.8	-1.4
Average weekly fortified wine intake	1.2	1.4	3.8	-0.7	-1.9	-1.2
Qualifications: CSEs or equivalent	1.2	1.6	2.6	1.4	1.4	1.6
Medication: Levothyroxine sodium	1.2	2.0	4.8	-1.3	1.2	2.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.6	-1.4	-1.2	-1.6
Birth weight of first child	1.2	2.1	4.2	1.2	1.7	2.1
Illnesses of siblings: Diabetes	1.2	1.4	5.2	0.7	-2.3	-0.2
Leg fat-free mass (right)	1.2	6.4	25.1	5.0	-0.1	0.7
Leg predicted mass (right)	1.2	6.3	24.5	5.0	-0.2	0.7
Hearing aid user	1.2	1.3	4.2	-0.9	-2.1	0.4
Arm fat-free mass (left)	1.2	5.9	21.5	4.6	0.2	1.4
Ever depressed for a whole week	1.2	1.5	4.4	-2.1	-1.2	-0.2
Vascular/heart problems diagnosed by doctor	1.2	3.2	5.5	2.3	-1.4	-2.3
Schizophrenia (2018)	1.1	2.3	4.4	-1.5	-2.1	-1.6
Leg fat-free mass (left)	1.1	5.7	22.0	4.7	-0.3	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.5	-2.1	-1.2	0.1
Leg predicted mass (left)	1.1	5.6	21.3	4.6	-0.3	1.0
Medication: Cholesterol lowering	1.1	1.7	6.2	-2.5	0.2	0.7
Arm fat-free mass (right)	1.1	5.8	18.7	4.3	0.7	2.0
Comparative body size at age 10	1.1	3.0	8.5	1.3	-2.9	-1.4
Emphysema/chronic bronchitis	1.1	1.2	4.6	-0.0	0.4	2.1
Arm predicted mass (right)	1.1	5.4	18.4	4.3	0.6	1.7
Number of full sisters	1.1	1.4	3.1	-1.8	0.6	1.4
Asthma (self-reported)	1.1	2.2	7.9	-2.8	0.5	-0.9
Number of self-reported non-cancer illnesses	1.1	1.9	6.0	-2.5	0.2	1.3
Arm predicted mass (left)	1.1	5.8	21.2	4.6	0.3	1.3
Bipolar Disorder or Schizophrenia	1.0	2.5	4.8	-2.2	-2.1	-0.9
Reaction Time	1.0	2.0	7.3	-2.7	-0.8	-0.1
Hand grip strength (left)	1.0	2.7	8.0	2.8	0.9	-1.4
Vitamin and mineral supplements	1.0	1.4	2.9	-1.7	-1.4	-0.9
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	2.5	1.6	-0.2	-1.6
Whole body fat-free mass	1.0	5.9	22.0	4.7	0.3	1.2
Whole body water mass	1.0	5.8	22.1	4.7	0.3	1.1
Basal metabolic rate	1.0	5.6	21.2	4.6	-0.1	1.2
Mean Putamen Volume	0.9	1.0	2.2	-1.5	1.3	0.3
BMI	0.9	5.5	11.0	3.3	-3.3	0.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	4.0	-2.0	-0.7	-0.2
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.9	-2.2	-0.6	-1.6
Impedance of leg (left)	0.9	4.4	17.2	-4.2	0.5	0.5
Pain all over the body in last month	0.9	1.0	2.4	-1.0	-1.5	0.8
Illnesses of siblings	0.9	1.3	2.5	1.6	1.4	-0.8
Weight	0.9	4.6	13.5	3.7	-1.1	1.9
Trunk fat-free mass	0.9	5.2	19.4	4.4	0.9	0.9
Falls in the last year	0.9	1.2	2.5	-1.6	-0.8	1.2
Trunk predicted mass	0.9	5.1	18.7	4.3	0.9	1.0
Exposure to tobacco smoke at home	0.9	1.0	3.6	-0.3	-1.9	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	4.0	-2.0	-0.3	-1.2
Forced vital capacity (FVC), Best measure	0.9	3.3	10.8	3.3	1.4	0.7
Medication: Blood pressure	0.9	1.5	4.9	-2.2	-1.1	-0.2
Leg fat mass (right)	0.9	3.4	5.9	2.0	-1.9	2.4
Qualifications: nursing, teaching	0.9	1.5	3.0	0.6	-1.7	-1.6
Eye problems/disorders: Glaucoma	0.9	1.1	3.3	-1.8	-0.6	-0.8
Leg fat mass (left)	0.9	3.5	5.5	2.2	-2.0	2.3
Prostate Cancer	0.8	1.1	3.2	1.8	1.1	-0.0
Relative age of first facial hair	0.8	1.6	5.0	2.2	1.1	0.6
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.1	1.5	-0.1	1.3
High blood pressure	0.8	2.2	5.0	-1.2	1.6	2.2
Supplements: Glucosamine	0.8	1.1	4.0	2.0	0.4	-0.2
Body mass index (BMI)	0.8	3.3	5.6	2.4	-2.3	1.6
Had menopause	0.8	1.0	2.8	0.5	0.9	1.7
Neuroticism score	0.8	1.6	6.2	-2.5	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	10.0	3.2	0.8	0.0
Arm fat mass (right)	0.8	3.3	6.4	2.5	-2.1	1.6
Pulse wave reflection index	0.8	1.0	2.3	-0.3	1.5	1.2
Gout (self-reported)	0.8	1.1	2.7	1.1	0.8	1.6
Qualifications: College or University degree	0.8	2.4	8.3	0.8	-0.8	-2.9
Whole body fat mass	0.8	3.4	5.1	1.8	-2.2	2.3
Hypertension (Self-reported)	0.8	2.3	4.8	-1.3	1.6	2.2
Friendships satisfaction	0.8	1.0	1.6	-1.1	-1.0	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.8	-1.9	-0.2	-1.0
Osteoarthritis (self-reported)	0.8	1.1	1.9	-1.3	-1.4	-0.9
Illnesses of father: None of the above (group 1)	0.8	0.9	1.9	1.3	1.4	0.2
Arm fat mass (left)	0.8	3.1	5.9	2.4	-2.1	1.5
Tinnitus: Yes, now most or all of the time	0.8	1.0	3.3	0.8	-0.0	1.8
Age started oral contraceptive pill	0.8	1.0	2.3	0.7	1.5	1.0
Impedance of whole body	0.8	4.0	16.1	-4.0	0.2	0.1
Neuroticism (Nagel 2018)	0.7	1.7	6.6	-2.6	0.3	-0.1
Ovarian Cancer	0.7	1.0	2.8	-1.7	-0.8	0.7
Sensitivity / hurt feelings	0.7	1.3	2.5	-1.6	-1.1	-1.2
Systolic blood pressure, automated reading	0.7	1.9	3.6	0.9	1.8	1.9
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.2	-0.7	-0.6	-1.5
Chronic bronchitis/emphysema (father)	0.7	0.8	2.2	-1.5	0.3	1.0
Trunk fat mass	0.7	3.0	5.6	1.8	-1.7	2.4
Waist circumference	0.7	2.4	4.1	2.0	-1.9	1.4
Past tobacco smoking	0.7	1.3	4.6	2.1	0.1	-0.7
Qualifications: None of the above	0.7	1.5	3.2	-1.7	0.3	1.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.5	-1.9	0.1	0.4
Hip circumference	0.7	2.9	5.8	2.0	-2.4	1.3
Impedance of arm (left)	0.7	3.1	12.4	-3.5	-0.1	-0.3
Body fat percentage	0.7	2.8	6.1	0.7	-2.5	2.2
Leg fat percentage (right)	0.7	2.6	5.9	0.4	-2.1	2.4
Worry too long after embarrassment	0.7	1.2	3.0	-1.1	0.7	-1.7
Pulse wave peak to peak time	0.7	0.8	1.5	0.6	-1.2	-1.2
Medication: Allopurinol	0.7	1.0	1.6	1.3	0.8	1.2
Medication: Seretide 50 evohaler	0.7	0.8	1.4	-0.9	1.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.9	0.9	2.0	1.2
Average weekly red wine intake	0.7	1.0	1.9	0.9	-1.4	-1.1
Mood swings	0.7	1.3	4.0	-2.0	0.5	0.9
Leg fat percentage (left)	0.7	2.7	5.1	0.9	-2.2	2.2
Worry (Nagel 2018)	0.6	1.2	2.4	-1.5	1.6	0.0
Alzheimer’s Disease (including proxy)	0.6	0.8	2.5	0.3	0.9	1.6
Crohns Disease (2017)	0.6	1.3	3.6	-1.9	-0.2	1.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.0	-1.0	2.0	0.8
Crohns Disease (2012)	0.6	1.0	4.0	-2.0	-0.2	0.1
LDL Cholesterol	0.6	1.0	2.5	-0.7	-1.1	-1.6
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.5	-1.4	0.4	1.6
Trunk fat percentage	0.6	2.6	5.5	0.8	-2.1	2.3
Medication: Atenolol	0.6	0.8	2.0	-1.4	0.5	1.0
Forced vital capacity (FVC)	0.6	2.1	7.6	2.8	0.9	0.3
Arm fat percentage (right)	0.6	2.6	7.3	1.2	-2.7	1.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	7.6	2.8	0.6	-0.1
Pulse wave Arterial Stiffness index	0.6	0.7	1.5	-0.1	1.2	1.2
Hair/balding pattern: Pattern 4	0.6	1.5	5.4	-2.3	0.7	-0.5
Glaucoma (self-reported)	0.6	0.7	2.3	0.3	0.7	-1.5
Number of children fathered	0.6	0.7	1.9	-1.0	0.3	1.4
Age at last live birth	0.6	0.9	3.4	-0.2	1.9	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	2.9	-1.7	0.4	-0.0
Arm fat percentage (left)	0.6	2.4	6.8	0.9	-2.6	1.4
Financial situation satisfaction	0.6	0.7	2.5	-0.5	-0.4	-1.6
Medication: Atorvastatin	0.6	0.8	1.7	-1.3	0.5	1.1
Fractured/broken bones in last 5 years	0.6	0.8	1.8	-1.0	0.7	1.4
Bipolar Disorder (2018)	0.5	0.8	2.5	-1.6	-0.8	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.1	-1.7	1.4	0.9
Bipolar Disorder (2011)	0.5	0.5	0.9	-0.7	1.0	0.7
Schizophrenia (2014)	0.5	1.2	2.7	-1.0	-1.6	-1.1
Alcohol usually taken with meals	0.5	0.8	2.3	1.0	-1.5	0.3
Diabetes (self-reported)	0.5	0.7	2.3	-1.5	0.5	0.6
Impedance of arm (right)	0.5	2.3	9.0	-3.0	-0.4	-0.4
Father’s age at death	0.5	0.7	2.5	0.5	-0.4	-1.6
Medication: Lansoprazole	0.5	0.6	2.1	-1.4	0.1	0.6
Standing height	0.5	4.7	10.9	3.3	2.6	1.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.0	1.7	0.3	-0.5
Heart disease (mother)	0.5	0.6	2.0	1.4	0.6	0.2
Alcohol intake frequency.	0.5	1.2	2.9	-1.3	-0.6	1.7
Ever had bowel cancer screening	0.5	0.6	2.1	-1.4	-0.5	-0.1
Commuting to job workplace: Walk	0.5	0.5	0.9	-0.6	-0.9	-1.0
Commuting to job workplace: Cycle	0.5	0.6	1.6	0.1	1.3	0.9
Coronary Artery Disease (CAD)	0.4	0.5	1.0	0.5	-0.9	-1.0
Blood Eosinophil Count	0.4	3.1	10.8	-3.3	1.0	0.7
Blood Platelet Count	0.4	5.1	13.0	-3.6	-1.1	2.5
Cardiovascular Disease	0.4	1.4	2.8	-1.5	0.7	1.7
Lung FVC	0.4	2.1	5.4	2.3	-1.6	-0.8
Severe depression (siblings)	0.4	0.4	1.0	-1.0	-0.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.1	0.3	1.1	1.4
Medication: Ramipril	0.4	0.5	1.1	-0.3	-0.8	1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.7	-0.1	0.7	-1.6
Prospective memory result	0.4	0.4	0.8	0.9	-0.5	-0.9
Tense / ‘highly strung’	0.4	0.6	2.1	-0.6	1.4	0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	1.8	-1.2	0.4	1.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.6	-1.3	0.5	0.2
Number of full brothers	0.4	0.5	1.9	0.2	-1.4	0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.0	-1.0	-0.5	-0.7
Migraine (self-reported)	0.4	0.5	1.0	1.0	-0.8	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.3	-0.4	-1.1	-0.5
Suffer from ‘nerves’	0.4	0.6	2.4	-1.5	0.0	-0.0
Had major operations	0.4	0.5	1.5	-1.2	0.7	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	0.6	-0.5	1.0
Illnesses of father: Heart disease	0.4	0.5	1.3	-0.8	-1.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.3	-0.5	1.1	0.2
Medication: Lisinopril	0.4	0.5	1.1	-0.9	1.0	0.4
Myopia	0.4	0.5	1.7	0.1	0.7	1.3
Alzheimer’s Disease (in father)	0.3	0.3	1.3	-0.1	-1.2	0.1
Breast Cancer	0.3	0.6	1.4	-1.2	-1.1	0.1
Fasting Glucose	0.3	0.4	0.6	-0.7	0.8	0.7
HbA1C	0.3	0.3	1.2	-1.1	0.3	-0.3
Rheumatoid Arthritis	0.3	0.4	1.0	0.7	-1.0	0.6
Blood White Count	0.3	2.1	7.8	-0.8	0.2	2.8
Hypothyroidism (self reported)	0.3	0.6	2.0	-1.4	-0.5	0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.6	-0.3	-0.1	1.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.9	0.9	-0.4	0.5
Diabetes (mother)	0.3	0.4	1.4	-1.2	0.5	0.3
Multivitamins +/- minerals	0.3	0.4	0.8	0.6	0.9	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.4	-1.2	0.2	-0.0
Had other major operations	0.3	0.3	0.7	0.7	0.9	0.2
Length of working week for main job	0.3	0.3	0.6	0.7	-0.6	-0.5
Breastfed as a baby	0.3	0.4	1.1	0.7	1.1	-0.1
Birth weight	0.3	0.6	1.1	1.0	-0.6	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	-0.5	0.4	0.9
Pulse rate, automated reading	0.3	1.0	2.2	1.5	-0.9	-0.9
Comparative height size at age 10	0.3	1.9	5.8	2.4	0.9	1.0
Smoking status: Previous	0.3	0.5	0.9	-1.0	0.4	0.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.9	-0.6	-0.5
Osteoporosis (self-reported)	0.3	0.4	1.5	1.2	0.3	-0.0
Commuting to job workplace: Public transport	0.3	0.3	1.2	-1.1	0.1	-0.1
Medication: Blood pressure	0.3	0.6	2.1	-0.5	1.4	0.3
Primary Biliary Cirrhosis	0.2	0.3	1.1	-1.0	0.1	0.0
Ulcerative Colitis	0.2	0.2	0.4	-0.6	0.3	-0.6
Height	0.2	3.4	11.9	3.5	0.9	1.0
Systolic Blood Pressure	0.2	0.9	2.2	-0.6	1.5	1.1
Lung FEV1/FVC ratio	0.2	1.2	2.5	0.4	-1.6	-1.4
Average weekly spirits intake	0.2	0.2	0.6	0.4	-0.8	0.1
Medication for hormone replacement therapy	0.2	0.3	0.7	-0.8	-0.6	0.2
Pack years adult smoking proportion	0.2	0.3	0.8	-0.9	-0.5	0.6
Age when periods started (menarche)	0.2	0.6	1.9	-1.4	0.6	0.2
Sitting height	0.2	1.4	2.8	1.7	1.6	0.4
Medication: Simvastatin	0.2	0.3	0.9	-0.9	-0.5	-0.3
Fluid intelligence score	0.2	0.5	1.6	-1.3	0.2	-0.5
Number of live births	0.2	0.3	0.6	0.8	-0.4	-0.6
Pulse rate	0.2	0.3	0.7	0.7	0.3	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.7	0.6	-0.9	0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	-0.4	-0.5	-0.8
Lung cancer (father)	0.2	0.3	1.0	1.0	-0.1	0.0
Illnesses of mother	0.2	0.2	1.0	0.1	-1.0	-0.1
Loud music exposure frequency	0.2	0.2	0.5	-0.1	0.7	0.7
Medication: Amlodipine	0.2	0.3	1.1	-1.1	0.2	-0.2
Age at first live birth	0.2	0.4	0.8	0.8	0.9	-0.1
Family relationship satisfaction	0.2	0.2	0.5	-0.7	0.5	0.3
Medication: Gliclazide	0.2	0.3	1.0	1.0	0.1	0.2
Average weekly champagne plus white wine intake	0.2	0.2	0.4	-0.7	0.6	0.3
Mother’s age at death	0.2	0.3	0.8	-0.9	0.2	-0.7
Alcohol drinker status: Never	0.2	0.2	0.4	0.6	-0.6	-0.2
Number of operations (self-reported)	0.2	0.3	0.6	0.5	0.8	0.4
Average weekly beer plus cider intake	0.2	0.2	0.6	0.8	0.5	-0.4
Irritability	0.2	0.3	1.2	0.0	1.1	-0.1
Diastolic blood pressure, automated reading	0.2	0.7	1.4	-0.3	1.2	1.2
Heart disease (siblings)	0.2	0.3	0.8	0.1	-0.6	0.9
Pack years of smoking	0.2	0.2	0.4	-0.6	-0.6	0.4
Schizophrenia vs Biploar Disorder	0.1	0.2	0.6	0.1	-0.8	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	-0.8	-0.0	0.4
Ulcerative Colitis (UC)	0.1	0.1	0.4	0.0	0.2	-0.6
Age at First Birth	0.1	0.1	0.5	0.7	-0.1	0.2
HDL Cholesterol	0.1	0.2	0.6	-0.6	-0.0	-0.8
Triglycerides	0.1	0.1	0.3	-0.1	-0.6	0.2
Heel T-Score	0.1	1.0	1.7	-1.1	1.3	1.1
Waist Hip Ratio (WHR)	0.1	0.7	2.0	-0.4	1.4	0.6
Chronotype (morning person)	0.1	0.3	0.6	-0.8	-0.1	0.6
Medication: Metformin	0.1	0.2	0.4	-0.3	0.4	0.6
High blood pressure (mother)	0.1	0.2	0.6	-0.7	0.3	-0.1
Number of incorrect matches in round	0.1	0.1	0.5	0.0	-0.7	-0.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.1	0.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.1	-0.1	0.4	1.1
Alcohol intake versus 10 years previously	0.1	0.1	0.5	0.7	-0.1	0.0
Worrier / anxious feelings	0.1	0.3	0.5	-0.6	-0.7	-0.5
Happiness	0.1	0.1	0.4	0.1	0.6	0.4
Depression (self-reported)	0.1	0.1	0.4	-0.6	0.3	-0.2
Peak expiratory flow (PEF)	0.1	0.3	0.8	0.6	-0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.5	0.7	-0.3	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.5	0.2	0.3
Medication for cholesterol	0.1	0.2	0.4	0.6	-0.1	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.5	-0.0	-0.3	-0.7
Breast cancer (self-reported)	0.1	0.2	0.4	0.5	0.2	0.6
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.3	0.5	-0.2
Cholesterol lowering medication	0.1	0.2	0.5	0.2	-0.7	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	-0.3	-0.6	-0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.2	-0.1	-0.2
Blood Red Count	0.0	0.3	0.6	0.5	-0.4	0.8
Hair Pigment	0.0	1.1	3.8	-0.4	2.0	0.7
Tanning	0.0	0.2	0.7	0.3	-0.9	0.3
Time employed in main current job	0.0	0.1	0.2	-0.1	0.0	0.5
Hair/balding pattern: Pattern 3	0.0	0.1	0.2	-0.5	0.2	0.1
Noisy workplace	0.0	0.1	0.1	-0.3	-0.2	0.4
Blood clot in the leg (DVT)	0.0	0.0	0.1	-0.2	-0.2	-0.2
Medication: Omeprazole	0.0	0.1	0.2	-0.1	0.5	0.0
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.2	-0.4	-0.0
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.2	-0.1	0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	-0.2	0.1	0.1

Hub : Genes

CPO

Models

Trait associations