TWAS hub - CPPED1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0620	0.0310	3.8e-02	0.020	0.000	-0.002	0.002	0.003	1.6e-03	2.8e-01	8.4e-01	1.5e-01	1.4e-01
2	GTEx	Nerve Tibial	0.2422	0.0797	1.7e-03	0.099	NA	0.041	NA	0.065	1.7e-07	NA	7.2e-04	NA	2.1e-05
3	GTEx	Thyroid	0.1840	0.0520	3.1e-05	0.064	NA	0.070	NA	0.077	1.2e-05	NA	5.1e-06	NA	1.5e-06
4	YFS	Blood	0.0705	0.0176	1.4e-08	0.024	0.028	0.047	0.049	0.047	1.4e-08	1.1e-09	3.7e-15	1.1e-15	3.8e-15
5	TCGA	Thyroid Carcinoma	0.0860	0.0320	4.0e-04	0.013	0.042	0.032	NA	0.028	1.9e-02	5.6e-05	3.9e-04	NA	9.4e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Number of full brothers	3.2	4.1	5.6	2.1	2.4	1.5	-1.7	2.3
Supplements: Zinc	2.9	3.1	5.9	-1.8	-2.4	-1.2	-2.2	0.5
Other serious medical condition/disability diagnosed by doctor	2.7	3.5	6.0	-0.1	2.5	2.1	1.7	2.0
Medication: Metformin	2.5	3.5	8.7	1.6	0.4	2.4	2.9	0.7
LDL Cholesterol	2.4	3.8	12.3	-0.4	3.5	-2.0	1.3	-1.1
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	6.0	0.4	-1.7	-1.9	-2.5	-1.5
Medication: Aspirin	2.2	2.9	9.2	1.3	1.2	0.4	3.0	1.3
Medication: Aspirin	2.2	2.9	11.3	1.2	1.0	0.3	3.4	0.8
Financial situation satisfaction	2.2	2.7	3.9	-1.6	-1.3	1.3	1.9	2.0
Had menopause	2.0	2.5	6.3	2.5	1.8	1.4	0.5	0.9
Diabetes (self-reported)	2.0	3.1	8.7	1.8	0.7	1.7	2.9	0.6
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	5.4	2.0	0.6	1.0	2.3	2.3
Overall health rating	2.0	4.3	6.9	1.4	2.5	1.6	2.6	2.0
Medication: Lisinopril	2.0	2.6	6.6	-1.0	-2.6	-1.1	0.5	-2.0
Severe depression (siblings)	1.9	2.1	5.3	-0.1	-0.6	-1.5	-1.5	-2.3
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.0	-1.7	-0.6	1.7	1.5	1.2
Chest pain or discomfort	1.9	2.8	7.8	0.7	0.4	2.2	0.7	2.8
Schizophrenia vs Biploar Disorder	1.8	2.4	4.2	-2.1	-1.9	1.5	1.0	1.0
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	18.0	-4.2	-2.5	-1.9	-1.0	-1.3
Ever highly irritable/argumentative for 2 days	1.8	2.2	6.0	0.6	-0.3	-2.1	-0.5	-2.4
HbA1C	1.7	1.8	3.5	-1.5	-0.9	1.5	-0.2	1.9
Supplements: Fish oil (including cod liver oil)	1.7	2.3	3.5	1.6	0.6	-1.9	-1.9	-1.2
Basal cell carcinoma (self-reported)	1.7	2.0	4.6	0.8	0.6	-1.8	-2.2	-1.1
Forced vital capacity (FVC)	1.6	6.1	17.5	-4.2	-2.7	-1.8	-1.2	-1.1
Trunk fat-free mass	1.6	9.1	19.0	-4.4	-2.1	-3.2	-0.7	-3.4
Comparative height size at age 10	1.6	8.7	27.4	-5.2	-3.4	-1.3	-0.8	-1.6
Ever had hysterectomy (womb removed)	1.5	1.7	3.2	-1.6	-1.8	0.7	-0.1	1.5
Stomach or abdominal pain in last month	1.5	1.9	4.0	-2.0	0.7	1.1	-0.3	2.0
Trunk predicted mass	1.5	8.6	18.1	-4.2	-2.1	-3.1	-0.7	-3.3
Glaucoma (self-reported)	1.5	1.8	5.4	-1.3	0.1	1.2	0.7	2.3
Diabetes diagnosed by doctor	1.5	2.5	6.4	1.3	1.0	1.7	2.5	0.9
Commuting to job workplace: Walk	1.5	1.6	4.0	-1.0	-2.0	-0.5	0.8	-1.5
Medication: Gliclazide	1.5	1.7	4.7	1.4	0.4	1.3	2.2	0.2
Smoking status: Current	1.5	2.4	6.4	-0.6	-0.4	2.1	0.6	2.5
Hearing aid user	1.5	1.6	3.3	-1.4	0.9	0.6	-1.3	1.8
Arm predicted mass (left)	1.5	7.5	13.5	-3.7	-1.4	-3.2	-0.4	-3.4
Current tobacco smoking	1.4	2.3	5.3	-0.4	-0.2	2.3	1.0	2.3
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.9	0.9	-1.2	-2.1	-2.6	-1.1
Lung cancer (father)	1.4	1.6	6.1	-1.4	2.5	0.3	0.2	0.4
Wheeze or whistling in the chest in last year	1.4	2.5	6.5	1.6	2.5	0.6	1.7	0.3
Whole body fat-free mass	1.4	8.0	18.8	-4.3	-1.9	-2.8	-0.5	-3.1
Long-standing illness, disability or infirmity	1.4	2.1	4.7	0.8	1.4	1.7	2.2	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	5.3	0.4	-0.3	2.3	0.7	1.1
Whole body water mass	1.4	8.2	18.5	-4.3	-1.9	-2.9	-0.6	-3.1
Smoking Status	1.3	3.0	7.8	-1.2	-0.8	2.2	0.7	2.8
Allergy or Eczema	1.3	3.5	7.7	0.9	-1.8	-1.9	-2.8	-1.5
Pack years adult smoking proportion	1.3	2.0	8.1	-0.1	0.5	0.6	2.8	1.1
Pain all over the body in last month	1.3	1.4	1.7	1.2	1.1	0.8	-1.3	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	11.0	-3.3	-1.6	-1.9	-0.4	-1.6
Arm predicted mass (right)	1.3	6.6	15.3	-3.9	-1.2	-2.9	-0.4	-2.8
Had major operations	1.3	1.5	3.4	1.2	1.8	0.4	1.1	1.1
Guilty feelings	1.3	1.9	5.6	2.4	1.9	-0.4	-0.3	-0.3
Basal metabolic rate	1.3	7.3	17.8	-4.2	-1.7	-2.6	-0.3	-3.0
Major Depression (MDD)	1.2	1.5	6.6	2.6	0.1	-0.5	-0.1	-0.7
Rheumatoid Arthritis	1.2	1.7	7.2	-2.7	0.8	-0.5	-0.6	-0.2
Average weekly spirits intake	1.2	1.5	2.5	-1.4	-1.0	1.6	0.6	1.3
Leg fat-free mass (left)	1.2	6.4	17.7	-4.2	-1.7	-2.1	-0.1	-2.7
Townsend deprivation index at recruitment	1.2	1.6	3.5	-0.1	1.6	1.2	1.9	0.7
Taking other prescription medications	1.2	1.8	5.4	-0.9	-0.8	1.5	-0.1	2.3
Leg predicted mass (left)	1.2	6.3	17.6	-4.2	-1.7	-2.0	-0.1	-2.6
Time employed in main current job	1.2	1.4	4.2	-2.1	-0.4	-0.5	-1.5	0.3
Arm fat-free mass (right)	1.2	6.3	15.2	-3.9	-1.3	-2.7	-0.5	-2.7
Pulse wave peak to peak time	1.2	1.5	3.3	-1.5	-1.4	0.0	-1.8	0.2
Medication for pain relief, constipation, heartburn	1.2	2.0	4.4	-0.8	-2.1	0.4	-1.8	-1.2
Ever had bowel cancer screening	1.2	1.4	5.4	0.7	-0.7	2.3	0.2	0.8
Eye problems/disorders: Cataract	1.2	1.3	4.7	-2.2	-0.7	0.4	1.2	0.1
Tinnitus: Yes, now most or all of the time	1.2	1.5	6.0	0.6	2.5	0.3	0.3	0.8
Ever smoked	1.2	2.0	5.0	-2.2	-1.0	1.2	1.0	1.3
Commuting to job workplace: Cycle	1.2	1.4	5.1	-0.2	-0.6	-2.2	-0.6	-1.2
Verbal and Numeric Reasoning (VNR)	1.1	2.5	5.4	1.1	-1.6	1.8	0.6	2.3
Fasting Glucose	1.1	1.3	5.0	0.8	2.2	0.3	-0.8	0.3
Hand grip strength (left)	1.1	3.0	8.9	-1.6	0.1	-3.0	-0.2	-1.8
High blood pressure (mother)	1.1	1.6	4.0	1.4	2.0	-1.1	0.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	6.2	2.5	1.2	-0.9	-0.3	-0.6
Pulse rate	1.1	1.9	6.6	-0.7	1.2	0.7	2.6	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	4.2	2.0	-0.3	0.5	-2.1	0.4
Loud music exposure frequency	1.1	1.2	4.1	-0.2	-0.9	0.6	-2.0	0.8
Medication: Ventolin 100micrograms inhaler	1.1	1.5	2.9	0.1	0.7	1.7	1.6	1.1
Forced vital capacity (FVC), Best measure	1.1	3.8	9.4	-3.1	-1.9	-1.8	-0.8	-1.5
Number of children fathered	1.1	1.3	3.2	-1.8	1.4	-0.5	-1.1	-0.1
Back pain experienced in last month	1.1	1.6	3.5	1.1	1.9	0.3	1.8	-0.4
Leg predicted mass (right)	1.1	5.6	16.6	-4.1	-1.4	-1.9	-0.3	-2.4
Medication: Atorvastatin	1.1	1.4	4.0	2.0	-0.2	-0.2	1.7	-0.2
Arm fat-free mass (left)	1.1	5.8	10.2	-3.2	-1.1	-2.9	-0.3	-3.0
Number of operations (self-reported)	1.1	1.7	3.0	1.0	1.0	1.7	0.8	1.7
Pack years of smoking	1.1	1.6	6.7	-0.0	0.3	0.5	2.6	0.9
Prostate Cancer	1.0	1.5	5.3	-1.1	-0.4	0.8	2.3	0.2
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.4	1.6	-0.9	0.9	-1.3	0.4
Relative age of first facial hair	1.0	2.0	5.1	1.2	0.4	2.2	-1.0	1.5
Vitamin and mineral supplements	1.0	1.4	3.7	0.5	-1.1	-0.2	1.9	-1.3
Had other major operations	1.0	1.3	5.7	0.2	0.1	2.4	0.1	0.8
Pulse wave Arterial Stiffness index	1.0	1.2	2.5	1.4	1.2	-0.0	1.6	-0.3
Impedance of arm (left)	1.0	4.7	8.6	2.2	-0.1	2.9	-1.1	2.9
Tense / ‘highly strung’	1.0	1.6	2.8	1.6	0.6	1.7	1.2	1.0
Leg fat-free mass (right)	1.0	5.6	15.7	-4.0	-1.4	-2.0	-0.4	-2.5
Asthma (self-reported)	1.0	2.0	4.4	0.7	1.7	1.3	2.1	0.5
Wears glasses or contact lenses	1.0	1.1	2.0	1.4	0.6	1.3	1.0	0.6
Ever taken oral contraceptive pill	1.0	1.1	2.4	-1.0	-1.5	-0.0	-1.1	-0.9
Medication: Bendroflumethiazide	1.0	1.5	4.5	-2.1	-1.2	0.9	0.5	0.6
Irritability	1.0	1.7	4.7	2.2	-0.0	-1.1	-0.1	-1.5
Age started oral contraceptive pill	1.0	1.3	2.8	0.6	1.7	0.8	1.1	1.1
Cholesterol lowering medication	1.0	1.5	6.1	0.4	0.5	0.7	2.5	0.8
HDL Cholesterol	0.9	1.5	4.5	-0.2	-2.1	0.6	-1.6	-0.3
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.5	0.5	0.4	1.7	2.1	0.8
Neuroticism	0.9	2.3	6.0	2.4	0.0	-1.9	-0.7	-1.2
Medication for hormone replacement therapy	0.9	1.0	2.0	-0.3	0.7	1.3	-1.0	1.4
Fed-up feelings	0.9	1.6	3.3	0.5	0.6	1.4	1.8	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	4.3	0.0	-1.4	-1.5	-1.0	-2.1
Neuroticism score	0.9	1.8	7.6	2.8	0.8	-0.7	-0.4	-0.4
Father’s age at death	0.9	1.2	3.5	0.4	-0.8	1.2	-0.3	1.9
Worrier / anxious feelings	0.9	1.6	4.9	2.2	0.5	-1.7	-0.1	-0.6
Medication: Cholesterol lowering	0.9	1.4	2.7	1.1	-1.5	-0.3	1.6	-0.7
Depression (self-reported)	0.9	1.1	3.6	0.1	-0.7	-0.5	-1.9	-1.0
Standing height	0.9	9.1	13.5	-3.3	-3.7	-2.9	-2.6	-2.5
Peak expiratory flow (PEF)	0.9	2.2	4.8	-2.2	-1.6	-1.0	-0.5	-1.5
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.6	-1.4	-1.9	-0.1	0.3	1.2
Loneliness, isolation	0.9	1.3	3.6	1.9	0.9	0.9	0.9	0.6
Osteoporosis (self-reported)	0.9	1.2	2.3	-1.4	0.1	1.5	-0.1	1.3
Osteoarthritis (self-reported)	0.9	1.2	2.9	-1.7	-1.4	0.5	0.5	0.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.9	1.2	-0.1	-0.9	-1.4	-1.0
Fractured/broken bones in last 5 years	0.9	1.2	2.9	-0.3	1.4	0.8	0.4	1.7
Impedance of whole body	0.9	4.5	8.5	2.8	0.3	2.3	-0.8	2.9
Neuroticism (Nagel 2018)	0.8	1.9	7.3	2.7	0.1	-1.4	0.5	-0.3
Alzheimer’s Disease (in father)	0.8	0.9	2.8	0.1	-1.7	0.6	-1.1	-0.5
Alzheimer’s Disease (including proxy)	0.8	1.2	3.9	-0.0	0.1	1.2	-0.7	2.0
Irritable Bowel Disease (IBD)	0.8	1.9	3.8	0.6	1.9	1.4	-0.1	1.9
Ulcerative Colitis (UC)	0.8	1.5	3.5	1.0	1.9	1.1	-0.7	1.2
Height	0.8	16.1	38.2	-3.1	-6.2	-2.3	-4.3	-3.0
Hand grip strength (right)	0.8	2.2	7.1	-1.7	0.1	-2.7	0.2	-1.0
Supplements: Glucosamine	0.8	1.0	2.2	1.5	-0.4	0.9	1.2	0.7
Medication: Atenolol	0.8	1.0	2.2	-1.0	-1.0	0.0	1.5	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	5.8	-1.3	-2.4	-0.6	-0.2	-1.2
Qualifications: None of the above	0.8	1.8	3.3	0.9	1.4	1.8	0.4	1.5
Medication: Simvastatin	0.8	1.2	5.0	-0.7	-0.5	0.2	2.2	0.1
Impedance of arm (right)	0.8	3.7	6.9	2.4	-0.5	2.6	-0.6	2.4
Number of live births	0.8	1.2	1.9	0.2	-0.4	1.4	-1.3	1.4
Medication: Lansoprazole	0.8	1.0	1.7	-1.2	-1.2	-0.7	0.0	-1.3
Illnesses of mother	0.8	0.9	1.9	0.0	-1.1	1.4	1.3	-0.0
Hair/balding pattern: Pattern 4	0.8	1.9	6.5	0.3	-0.8	-2.5	0.8	-1.3
Age at first live birth	0.8	1.4	2.5	-1.5	-0.6	0.7	1.6	1.1
Medication: Blood pressure	0.8	1.5	5.6	0.9	0.7	0.3	2.4	-0.7
Pulse rate, automated reading	0.8	2.5	5.7	0.2	0.4	2.3	2.4	1.0
Average weekly red wine intake	0.8	1.2	3.7	-1.3	-0.4	-0.5	-1.9	0.3
Qualifications: nursing, teaching	0.8	1.2	2.7	-1.2	-1.0	0.9	1.6	0.5
Medication: Paracetamol	0.8	1.3	3.1	1.7	1.1	-1.2	-0.3	-0.7
Pain experienced in last month	0.8	1.3	2.7	-0.5	-1.1	1.6	-0.1	1.6
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	0.1	0.9	-0.2	-1.1	1.3
Crohns Disease (2017)	0.7	1.6	3.4	0.1	1.4	1.4	0.7	1.9
Breast Cancer	0.7	1.6	4.0	1.4	2.0	-0.8	1.0	-0.6
Bipolar Disorder (2011)	0.7	0.7	1.7	1.1	1.3	0.1	-0.3	-0.8
Schizophrenia (2014)	0.7	1.5	2.7	-0.2	1.6	1.5	-0.0	1.6
Ulcerative Colitis	0.7	1.0	1.9	1.2	1.1	0.6	-1.4	0.5
Respiratory disease	0.7	1.6	4.0	-0.7	0.4	2.0	1.2	1.3
Number of treatments/medications taken	0.7	1.3	3.0	0.1	-0.2	1.2	1.3	1.7
Relative age voice broke	0.7	1.1	3.2	1.8	-0.6	0.2	-1.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.2	0.2	0.2	1.3	-0.0	1.5
Multivitamins +/- minerals	0.7	0.9	2.5	0.3	0.6	-0.7	-1.6	0.9
Number of incorrect matches in round	0.7	1.2	3.3	-0.0	0.9	-1.8	-1.3	-0.4
Past tobacco smoking	0.7	1.3	1.9	1.4	1.0	-1.2	-0.5	-1.3
Weight	0.7	3.4	9.5	-3.1	-0.8	-1.5	0.6	-2.1
Hair/balding pattern: Pattern 3	0.7	1.0	3.2	1.4	1.8	0.2	0.1	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.3	-0.6	-0.5	-1.5	-0.3	-1.1
Neck or shoulder pain in last month	0.7	0.9	1.9	0.4	1.4	-1.1	0.9	-0.7
Medication: Seretide 50 evohaler	0.7	0.8	3.2	1.8	0.7	-0.2	0.5	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.9	-0.1	-1.4	0.7	-1.2	0.6
Family relationship satisfaction	0.7	0.9	1.9	0.6	1.0	0.7	1.4	0.7
Leg pain on walking	0.7	0.9	2.0	-0.1	1.4	-1.4	-0.2	-0.8
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.4	-0.7	0.5	0.2	-1.6	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	3.6	0.2	1.9	-0.2	0.5	0.6
Commuting to job workplace: Public transport	0.7	0.9	2.8	0.6	-0.9	0.6	1.7	0.1
Eye problems/disorders: Glaucoma	0.7	0.8	2.5	-1.0	-0.2	0.1	0.6	1.6
Average weekly beer plus cider intake	0.7	1.0	2.4	1.6	-0.1	1.4	0.6	0.5
Depression (Nagel 2018)	0.6	0.9	2.3	1.5	-0.8	-1.0	-0.6	-0.3
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.6	0.5	-1.4	1.9	0.7	1.8
Primary Biliary Cirrhosis	0.6	0.8	1.7	0.6	0.6	-0.8	1.0	-1.3
Triglycerides	0.6	1.0	2.9	0.7	1.7	-0.9	-0.6	-0.8
Sensitivity / hurt feelings	0.6	1.1	2.1	1.4	1.1	-1.0	-0.2	-0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.3	-0.8	0.0	1.1	-1.1	0.7
Systolic blood pressure, automated reading	0.6	1.6	3.7	-0.8	-0.8	1.9	1.2	1.3
Average weekly fortified wine intake	0.6	0.7	1.2	-0.9	-1.1	0.6	-1.1	0.3
Age when periods started (menarche)	0.6	1.4	2.7	1.6	1.6	-0.2	1.3	0.5
Sitting height	0.6	4.2	8.2	-2.9	-2.2	-2.2	-1.0	-1.6
Impedance of leg (left)	0.6	2.7	7.5	2.7	0.4	0.9	-0.7	2.1
Medication: Ramipril	0.6	0.7	2.7	-0.8	-0.1	-0.2	1.6	-0.4
Falls in the last year	0.6	0.8	3.2	1.8	0.8	0.1	-0.5	0.1
Asthma	0.6	1.3	2.7	0.5	1.6	0.8	1.6	0.2
Prospective memory result	0.6	0.8	2.6	0.7	0.8	0.4	1.6	-0.3
Medication: Paracetamol	0.6	1.1	2.4	0.9	1.6	-1.4	-0.3	0.4
Medication: Amlodipine	0.6	0.8	1.8	0.7	-0.6	-1.3	0.2	-1.1
Eye problems/disorders: None of the above	0.6	0.7	3.0	0.3	0.0	-0.4	-1.7	-0.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.0	-0.3	-1.2	0.3	-1.4	0.1
Emphysema/chronic bronchitis	0.6	0.6	1.0	-0.5	-0.7	1.0	1.0	0.6
Heart disease (mother)	0.6	0.8	2.6	0.5	-0.5	-0.7	1.6	0.6
Number of full sisters	0.6	0.7	1.3	0.9	-1.2	-0.5	-0.5	-0.9
Knee pain experienced in last month	0.6	0.9	2.4	0.1	-0.7	0.9	1.6	-1.0
Illnesses of father: Heart disease	0.6	0.9	2.9	-1.7	-1.1	-0.3	-0.2	-0.6
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.9	0.5	1.4	0.3	1.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	3.1	-1.8	-1.4	-0.4	0.3	-1.2
Medication: Blood pressure	0.6	1.1	2.9	-1.6	-1.7	0.3	0.2	0.2
Diastolic blood pressure, automated reading	0.6	1.8	5.2	-1.7	0.5	0.2	2.3	0.8
Worry (Nagel 2018)	0.5	1.1	4.0	2.0	-0.5	-1.1	-0.2	0.1
Coronary Artery Disease (CAD)	0.5	0.6	2.1	-0.5	0.3	-1.4	-0.6	-0.7
Chronotype (morning person)	0.5	1.1	4.0	0.0	-0.7	-0.9	-2.0	-0.6
Hearing difficulty/problems: Yes	0.5	0.7	2.1	1.0	1.5	0.5	-0.3	0.3
Diabetes (father)	0.5	0.7	2.4	-1.6	-0.5	-0.5	-0.6	-0.2
Maternal smoking around birth	0.5	0.8	1.6	-0.7	1.1	1.3	0.7	0.3
Chronic bronchitis/emphysema (father)	0.5	0.6	1.5	1.0	0.2	-0.1	-1.2	0.5
Hearing difficulty/problems with background noise	0.5	0.8	1.3	1.2	1.1	-0.9	0.6	-0.3
Hair/balding pattern: Pattern 2	0.5	0.7	1.3	-0.4	1.1	1.0	0.7	0.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.9	0.5	-1.4	0.7	0.5	0.0
Illnesses of siblings	0.5	0.8	1.8	-1.3	-0.7	-0.8	0.9	-0.4
Hip circumference	0.5	2.1	7.2	-2.7	-0.4	-0.7	0.2	-1.6
Alcohol intake versus 10 years previously	0.5	0.8	3.5	0.0	-0.3	0.3	1.9	-0.6
Happiness	0.5	0.6	1.5	0.4	0.6	0.8	1.2	-0.3
Noisy workplace	0.5	0.6	1.0	-0.1	-0.6	-1.0	-0.8	-0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.2	4.3	-2.1	-0.8	-0.2	0.9	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.0	0.2	1.4	0.3	-0.3	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.5	0.2	1.6	0.1	0.2	0.8
Pulse wave reflection index	0.5	0.6	1.3	-0.1	0.3	-1.1	-0.2	-1.2
Blood clot in the leg (DVT)	0.5	0.7	2.5	1.6	0.6	0.5	0.1	0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.8	-0.3	0.1	0.1	-1.9	0.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.5	1.2	1.6	-0.7	0.5	-0.6
Worry too long after embarrassment	0.5	0.8	3.4	1.8	-0.4	-0.5	-0.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.4	1.5	0.3	-0.3	-0.6	-0.8
Qualifications: College or University degree	0.5	1.6	3.1	-1.6	-0.3	-1.8	0.7	-1.2
Supplements: Vitamin C	0.5	0.5	1.3	-1.1	0.5	-0.1	-1.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.4	-1.8	-1.5	-0.1	-0.3	0.0
Friendships satisfaction	0.5	0.6	1.2	0.2	-0.2	0.7	1.1	1.1
Medication for cholesterol	0.5	0.8	2.3	1.5	1.1	-0.3	-0.2	-0.6
Illnesses of father: None of the above (group 1)	0.5	0.6	1.2	-0.4	0.6	-1.1	0.6	-0.8
Number of self-reported non-cancer illnesses	0.5	0.8	1.4	-0.4	-1.2	1.2	0.4	1.1
High cholesterol (Self-reported)	0.5	0.9	2.8	0.9	-0.3	-0.4	1.7	-0.5
Alcohol drinker status: Never	0.5	0.6	1.4	-0.1	-1.2	0.4	-1.2	0.4
Unable to work because of sickness or disability	0.5	0.7	2.3	0.7	0.4	1.5	0.4	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	1.3	0.6	0.6	0.4	0.7
Heart disease (siblings)	0.5	0.7	1.9	0.0	-1.4	0.9	-0.6	0.5
Bipolar Disorder or Schizophrenia	0.4	1.1	3.5	1.0	1.9	0.3	0.0	0.9
Schizophrenia (2018)	0.4	0.8	2.8	0.6	1.7	0.0	-0.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.5	0.3	0.5	0.3	0.1	-1.2
Angina	0.4	0.5	1.9	0.2	-0.2	0.4	0.5	1.4
Diabetes (mother)	0.4	0.6	0.9	-0.9	0.4	0.6	-0.9	0.7
High blood pressure	0.4	1.1	2.2	-1.1	-1.5	0.8	1.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	0.8	-0.1	-0.6	-1.2	0.2
Body mass index (BMI)	0.4	1.6	3.0	-1.7	0.9	-0.3	1.7	-1.1
Alcohol usually taken with meals	0.4	0.6	1.7	-1.3	0.2	-0.7	-0.7	-0.5
Allergy	0.4	0.9	3.1	-0.4	0.1	0.9	1.8	0.6
Fluid intelligence score	0.4	0.8	2.2	1.2	-0.2	0.2	-0.1	1.5
Arm fat mass (right)	0.4	1.5	5.1	-2.2	0.2	-0.2	1.1	-1.1
Breastfed as a baby	0.4	0.5	1.7	0.8	0.3	-1.3	-0.1	-0.4
Birth weight of first child	0.4	0.8	2.2	-0.5	-0.4	-1.5	-0.4	-1.1
Headache pain in last month	0.4	0.6	1.0	-0.8	0.7	-1.0	0.9	0.3
Gout (self-reported)	0.4	0.6	2.6	0.1	-0.4	0.3	1.6	0.3
High blood pressure (siblings)	0.4	0.6	1.5	1.2	0.9	0.5	-0.3	0.2
Exposure to tobacco smoke outside home	0.4	0.6	1.6	-0.3	0.1	-0.3	1.3	-1.0
Comparative body size at age 10	0.4	1.1	1.6	-1.2	-0.1	-1.2	-1.1	-1.0
Medication: Ibuprofen	0.4	0.5	1.4	0.7	1.2	0.2	0.4	0.7
Medication: Omeprazole	0.4	0.4	0.7	-0.9	0.5	0.3	0.7	0.7
Age at last live birth	0.4	0.5	1.4	-0.3	-0.5	0.1	1.2	0.9
Breast cancer (self-reported)	0.4	0.4	0.6	0.7	-0.3	0.8	-0.7	0.8
Average weekly champagne plus white wine intake	0.4	0.5	1.0	1.0	-0.1	-0.5	-1.0	-0.4
Miserableness	0.4	0.7	2.2	1.5	0.2	0.1	0.9	0.5
Mother’s age at death	0.4	0.5	2.1	-0.5	0.3	0.3	-1.4	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	-0.7	-0.8	-0.1	-0.1	-1.0
Illnesses of father: High blood pressure	0.4	0.5	0.9	-0.9	-0.5	1.0	0.5	-0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.6	0.9	0.1	0.2	1.3	0.2
Bipolar Disorder (2018)	0.3	0.6	0.8	0.8	0.9	0.5	0.7	0.8
Depressed Affect (Nagel 2018)	0.3	0.6	1.8	1.3	-0.1	-0.4	1.0	0.4
Reaction Time	0.3	0.5	1.4	0.3	-0.2	0.1	1.2	-1.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	-0.5	1.2	-0.1	0.4	0.5
Lupus	0.3	0.5	1.5	-1.2	-0.7	0.4	0.3	-0.4
Blood Eosinophil Count	0.3	2.6	4.4	1.2	2.0	1.4	2.1	1.2
Systolic Blood Pressure	0.3	1.3	3.4	-0.8	-0.3	1.8	0.4	1.5
Hypothyroidism (self reported)	0.3	0.7	1.3	1.1	0.9	0.4	1.1	-0.4
Medication: Co-codamol	0.3	0.4	1.3	-0.7	0.2	0.1	1.1	-0.3
Impedance of leg (right)	0.3	1.4	4.5	2.1	-0.4	0.5	-0.4	1.5
Qualifications: CSEs or equivalent	0.3	0.4	0.7	0.4	0.3	-0.8	-0.5	-0.8
Waist circumference	0.3	1.1	2.8	-1.7	0.3	-0.5	1.2	-0.9
Financial difficulties in last 2 years	0.3	0.4	1.0	-0.0	0.0	0.6	1.0	0.8
Mouth/teeth dental problems	0.3	0.4	1.1	-0.4	0.5	-0.7	-1.1	-0.5
Heart attack	0.3	0.4	1.3	0.8	-0.0	-0.0	1.2	0.0
Arm fat percentage (right)	0.3	1.0	2.2	-1.2	0.8	0.8	1.5	-0.4
Length of working week for main job	0.3	0.4	1.4	0.0	0.1	-0.5	-1.2	-0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.5	-0.6	0.6	-0.6	0.7	-0.4
Angina (self-reported)	0.3	0.4	1.8	-0.1	-0.2	0.4	0.2	1.4
Mean time to correctly identify matches	0.3	0.5	1.4	0.6	0.0	0.8	1.2	-0.6
Leg fat mass (right)	0.3	1.3	3.6	-1.9	0.3	-0.5	1.1	-1.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	0.1	-0.9	0.4	0.9	-0.4
Hypertension (Self-reported)	0.3	0.9	1.7	-0.5	-1.2	0.8	1.3	0.6
Illnesses of siblings: Diabetes	0.3	0.3	1.2	0.2	0.5	0.4	0.1	1.1
Smoking status: Previous	0.3	0.4	1.0	-0.6	-1.0	0.5	0.8	0.2
Arm fat percentage (left)	0.3	1.1	2.2	-1.2	0.9	1.1	1.5	0.1
Mineral and other dietary supplements	0.3	0.5	1.1	-0.9	0.1	0.7	1.0	0.2
Arm fat mass (left)	0.3	1.1	3.8	-2.0	0.3	-0.3	0.8	-1.0
Risk taking	0.3	0.4	1.1	0.3	0.6	-0.7	-1.1	-0.2
Ever depressed for a whole week	0.3	0.3	0.9	0.9	-0.4	-0.6	0.5	-0.3
Myopia	0.3	0.5	1.2	0.4	-1.1	0.6	-0.2	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.0	1.0	1.0	-0.6	-1.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.5	-0.5	0.5	-0.0	1.2	0.0
Leg fat mass (left)	0.3	1.1	3.2	-1.8	0.4	-0.4	0.9	-1.1
Age at First Birth	0.2	0.3	0.5	-0.2	0.7	0.5	-0.5	0.6
Crohns Disease (2012)	0.2	0.4	1.0	-0.5	1.0	-0.6	-0.2	0.2
Blood Red Count	0.2	1.6	2.7	-1.6	0.3	-1.6	1.1	-1.3
Blood White Count	0.2	1.8	6.3	-2.5	1.2	0.3	1.1	-0.2
BMI	0.2	1.1	2.2	-1.1	0.8	-0.8	1.0	-1.5
Cardiovascular Disease	0.2	0.7	2.0	-0.7	-0.4	-0.7	1.4	-0.5
Lung FEV1/FVC ratio	0.2	1.1	4.8	-2.2	-0.1	-0.1	0.7	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.1	1.1	-0.3	-0.4	0.0	0.2
Serious illness, injury or assault to yourself	0.2	0.3	1.0	-0.0	0.2	-0.2	-1.0	0.7
Medication: Levothyroxine sodium	0.2	0.3	1.0	-0.4	1.0	0.3	0.3	0.3
Nervous feelings	0.2	0.4	1.2	0.8	0.2	-1.1	-0.4	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.2	-0.4	-0.5	0.9	-0.3
Birth weight	0.2	0.5	1.4	-0.5	-1.2	-0.7	-0.4	-0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.6	-0.0	0.2	-0.8	-0.0
Body fat percentage	0.2	0.7	1.7	-0.6	0.8	0.9	1.3	0.1
Leg fat percentage (right)	0.2	0.8	2.1	-0.7	0.8	0.1	1.5	-0.7
Health satisfaction	0.2	0.3	0.7	-0.5	0.8	-0.1	0.8	0.3
Shortness of breath walking on level ground	0.2	0.3	0.7	-0.2	-0.1	0.3	0.8	-0.7
Migraine (self-reported)	0.2	0.3	0.6	-0.4	-0.7	-0.4	-0.6	0.2
Whole body fat mass	0.2	1.0	3.1	-1.8	0.2	-0.0	1.0	-0.8
Suffer from ‘nerves’	0.2	0.3	0.8	0.9	0.9	0.0	0.0	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.2	-0.4	0.2	-0.6	0.5
Leg fat percentage (left)	0.2	0.6	1.3	-0.5	1.1	0.1	1.2	-0.6
Supplements: Calcium	0.2	0.2	0.6	-0.8	0.2	0.3	0.4	-0.1
Mean Putamen Volume	0.1	0.1	0.3	-0.4	-0.2	-0.4	0.2	-0.5
Neuroticism (2016)	0.1	0.1	0.3	-0.1	0.2	0.1	-0.1	0.6
Blood Platelet Count	0.1	1.7	4.0	-1.9	0.1	-0.0	-0.9	-2.0
Heel T-Score	0.1	0.8	3.4	-0.3	-0.6	-0.0	0.5	-1.8
Waist Hip Ratio (WHR)	0.1	0.3	1.0	0.1	-0.3	-0.6	1.0	0.5
Lung FVC	0.1	0.6	1.5	-1.2	-0.9	0.1	0.8	0.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.7	0.8	0.1	-0.2	0.3	0.5
Trunk fat percentage	0.1	0.5	1.1	-0.5	0.5	1.1	0.8	0.5
Trunk fat mass	0.1	0.6	2.3	-1.5	0.1	0.2	0.7	-0.6
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.3	-0.2	-0.4	0.0	-0.2
Medication: Allopurinol	0.1	0.2	0.4	0.6	0.4	-0.2	0.5	0.3
Alcohol intake frequency.	0.1	0.3	0.8	0.5	-0.3	0.2	0.9	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.3	-0.6	0.3	-0.2	-0.2
Mood swings	0.1	0.2	0.7	0.3	0.2	-0.8	-0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.3	0.7	0.5	-0.1	0.2
Alcohol drinker status: Previous	0.1	0.2	0.5	-0.7	0.3	0.4	-0.2	0.2
Ovarian Cancer	0.0	0.0	0.1	0.2	0.2	-0.0	0.1	-0.3
Hair Pigment	0.0	1.1	3.1	-0.6	1.8	0.7	-0.7	1.0
Tanning	0.0	0.3	0.7	0.5	-0.3	-0.7	0.9	0.2

Hub : Genes

CPPED1

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