Hub : Genes

CREB3L2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1910	0.0750	0.0094	0.049	NA	0.074	NA	0.058	1.1e-03	NA	6.5e-05	NA	3.9e-04
2	GTEx	Muscle Skeletal	0.1262	0.0425	0.0039	0.081	NA	0.103	NA	0.095	2.2e-08	NA	3.0e-10	NA	1.3e-09
3	ROSMAP	Brain Pre-frontal Cortex	0.0526	0.0218	0.0066	0.002	0.009	0.012	0.008	0.011	1.6e-01	0.023	9.0e-03	0.027	1.2e-02
4	TCGA	Breast Invasive Carcinoma	0.0143	0.0070	0.0043	0.004	0.007	0.000	NA	0.001	3.5e-02	0.010	3.3e-01	NA	1.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.7	1.2	0.6	-1.1	1.0	0.7
Bipolar Disorder or Schizophrenia	0.5	1.2	2.6	1.6	0.3	1.0	1.0
Depressed Affect (Nagel 2018)	0.4	0.9	1.8	-0.8	0.1	-1.3	-1.1
Depression (Nagel 2018)	0.2	0.2	0.4	0.4	-0.6	-0.3	-0.6
Intelligence (Savage-Jansen 2018)	0.6	1.9	2.4	1.5	1.5	1.2	1.3
Neuroticism (Nagel 2018)	0.1	0.1	0.4	-0.1	-0.3	-0.1	-0.6
Schizophrenia (2018)	0.6	1.3	2.7	1.6	1.3	0.6	0.8
Schizophrenia vs Biploar Disorder	0.7	0.9	2.8	-1.7	0.1	-0.8	-0.4
Worry (Nagel 2018)	0.1	0.2	0.5	0.7	-0.3	0.5	0.1
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	-1.3	0.8	-0.5	-0.7
Alzheimer’s Disease (in father)	2.0	2.2	4.5	2.1	-1.6	1.3	0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	0.3	-1.0	0.2	-0.7
Crohns Disease (2017)	0.2	0.4	0.9	-0.3	-0.6	-0.6	-0.9
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.7	0.9	0.1	-0.1
Ulcerative Colitis (UC)	0.9	1.6	5.5	-1.0	2.3	0.3	0.2
Major Depression (MDD)	2.9	3.5	7.9	1.0	-1.5	2.8	1.7
Reaction Time	0.4	0.7	1.2	-0.5	-1.1	1.1	0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.3	-0.1	1.5	0.2	-0.5
Breast Cancer	0.1	0.1	0.3	-0.6	0.3	0.4	0.1
Ovarian Cancer	0.4	0.5	1.0	1.0	0.1	0.9	0.5
Prostate Cancer	0.4	0.6	1.4	0.6	1.2	0.7	0.1
Age at First Birth	0.6	0.8	1.7	0.8	1.3	-1.0	-0.2
Bipolar Disorder (2011)	1.4	1.4	3.3	0.0	0.0	-1.8	-1.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.4	-0.0	-0.5	-0.4
Coronary Artery Disease (CAD)	0.3	0.3	0.6	-0.7	-0.6	-0.2	-0.7
Crohns Disease (2012)	0.1	0.1	0.2	-0.5	-0.2	0.3	0.1
Mean Putamen Volume	0.2	0.2	0.6	0.2	0.3	0.1	0.8
Fasting Glucose	2.5	3.0	4.8	-2.2	-0.8	-2.2	-1.3
HbA1C	1.7	1.9	3.4	-0.6	-1.2	-1.8	-1.5
HDL Cholesterol	1.4	2.3	3.7	1.4	0.3	1.9	1.9
LDL Cholesterol	0.5	0.9	1.5	-0.4	-1.2	0.6	1.2
Lupus	0.3	0.4	1.2	-0.5	1.1	-0.0	-0.5
Neuroticism (2016)	0.4	0.6	1.2	-0.1	0.7	-0.8	-1.1
Primary Biliary Cirrhosis	0.5	0.7	1.5	-1.2	0.0	-0.6	-1.0
Rheumatoid Arthritis	0.1	0.2	0.3	0.5	-0.4	0.5	0.1
Schizophrenia (2014)	0.4	1.0	3.6	0.4	1.9	0.2	0.4
Triglycerides	1.3	2.1	5.2	-1.0	1.0	-1.0	-2.3
Type 2 Diabetes (T2D) (2012)	6.2	7.1	13.5	-1.5	1.9	-3.0	-3.7
Ulcerative Colitis	0.6	0.8	1.7	0.6	1.3	0.8	0.7
Blood Eosinophil Count	0.3	2.3	4.8	-1.0	0.3	2.2	1.9
Blood Platelet Count	0.5	5.2	10.1	1.0	0.5	3.2	3.1
Blood Red Count	0.1	0.8	2.6	-0.5	-0.2	-1.6	-0.4
Blood White Count	0.5	3.4	7.3	-2.0	-0.4	-1.5	-2.7
Heel T-Score	0.0	0.3	1.1	0.2	-0.5	-0.0	1.0
BMI	1.3	7.6	12.4	1.9	-2.4	3.5	2.9
Height	4.0	76.7	153.8	-5.2	5.3	-9.9	-12.4
Waist Hip Ratio (WHR)	1.3	5.8	15.8	-0.8	0.5	-2.5	-4.0
Systolic Blood Pressure	1.0	4.8	12.3	-3.5	1.6	-1.7	-1.2
Smoking Status	1.0	2.5	6.2	-1.3	1.2	-0.8	-2.5
Allergy or Eczema	1.6	4.1	7.1	1.6	1.6	2.7	2.1
Cardiovascular Disease	0.5	1.8	3.5	-1.1	-0.7	1.3	1.9
Hypothyroidism (self reported)	0.5	1.2	2.9	-0.1	-1.7	1.3	0.2
Respiratory disease	0.6	1.3	4.0	0.5	0.2	2.0	0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	-0.8	-0.6	-0.5	-0.6
Lung FEV1/FVC ratio	0.6	3.1	7.2	2.7	-0.9	1.6	1.4
Lung FVC	1.5	7.5	11.6	2.9	2.5	2.0	3.4
Neuroticism	0.5	1.1	3.8	2.0	-0.5	0.3	-0.6
Chronotype (morning person)	0.3	0.7	1.9	-0.5	1.4	-0.8	-0.1
Hair Pigment	0.0	0.9	3.3	0.5	0.1	0.1	1.8
Tanning	0.1	1.0	3.6	-0.6	1.9	-0.0	-0.2
Hand grip strength (left)	0.2	0.4	0.8	-0.9	0.3	0.9	0.0
Number of treatments/medications taken	0.9	1.7	3.2	-0.2	-1.8	1.8	0.7
Average weekly spirits intake	0.2	0.3	1.1	0.2	0.1	-0.2	-1.1
Sensitivity / hurt feelings	0.1	0.2	0.7	-0.4	-0.2	-0.0	-0.9
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	0.7	-0.8	0.5	0.4
Hearing difficulty/problems: Yes	0.6	0.9	2.4	0.4	1.6	0.9	0.0
Relative age of first facial hair	1.3	2.7	6.4	-2.5	0.4	-1.5	-1.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.0	-0.5	0.6	0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	-0.2	0.3	-0.2	-0.9
Ever had hysterectomy (womb removed)	0.4	0.5	1.3	-0.5	-1.1	0.6	0.1
Systolic blood pressure, automated reading	1.6	4.6	7.0	-2.6	0.9	-2.6	-1.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.2	-1.8	-0.4	-0.5	-1.0
Angina	0.3	0.3	0.6	-0.5	-0.8	0.2	0.7
Medication for hormone replacement therapy	0.4	0.5	1.8	-1.4	-0.0	-0.2	-0.1
Vitamin and mineral supplements	0.8	1.1	1.6	0.4	-1.2	1.1	1.3
Supplements: Zinc	3.9	4.2	6.1	2.1	-1.1	2.5	2.3
Medication: Co-codamol	0.4	0.4	1.5	-1.2	-0.3	0.3	-0.2
Medication: Metformin	0.4	0.6	1.3	-0.5	0.1	-0.9	-1.1
Diabetes (father)	0.3	0.4	0.8	0.8	-0.3	-0.1	0.9
Diabetes (mother)	2.2	2.8	4.8	-2.1	-0.0	-1.3	-2.2
Severe depression (siblings)	0.6	0.7	1.9	0.8	1.4	0.3	-0.2
Pack years adult smoking proportion	1.3	2.0	3.3	-1.8	-1.4	1.6	0.3
Impedance of leg (right)	1.7	8.2	18.4	-1.2	1.4	-3.3	-4.3
Leg fat-free mass (left)	0.0	0.2	0.8	0.1	-0.2	-0.1	-0.9
Trunk fat percentage	0.9	3.7	11.5	0.1	-0.1	-1.8	-3.4
Hand grip strength (right)	0.3	0.8	2.0	-0.8	0.1	1.4	0.7
Townsend deprivation index at recruitment	0.2	0.3	0.9	0.2	0.1	1.0	0.4
Current tobacco smoking	0.6	1.0	1.8	-0.3	-1.1	1.4	-1.0
Average weekly fortified wine intake	1.3	1.6	3.2	-0.8	-0.1	1.6	1.8
Maternal smoking around birth	0.4	0.6	1.2	-1.1	-0.7	0.8	-0.2
Fed-up feelings	0.3	0.6	1.4	-0.1	-0.5	-1.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	-1.1	-0.7	-0.6	-0.5
Relative age voice broke	1.3	2.0	4.2	-2.0	0.2	-1.2	-1.5
Taking other prescription medications	1.9	2.9	7.4	-0.0	-2.7	2.0	0.3
Age when periods started (menarche)	1.1	2.6	5.1	-0.8	-0.7	-2.3	-2.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.0	-0.3	-0.7	0.5	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	7.8	-0.7	-2.8	-0.2	1.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.3	-0.1	0.4	-0.5	-0.5
Qualifications: CSEs or equivalent	1.0	1.4	2.1	-1.2	-1.4	-1.3	-0.6
Serious illness, injury or assault to yourself	1.8	2.2	6.0	-1.0	0.5	-1.2	-2.4
High blood pressure	0.1	0.4	0.7	-0.7	-0.4	0.4	0.8
Hayfever, allergic rhinitis or eczema	2.1	4.6	8.8	0.9	1.3	3.0	2.6
Multivitamins +/- minerals	0.2	0.2	0.4	0.5	0.1	0.6	0.6
Stomach or abdominal pain in last month	0.3	0.3	0.7	0.1	-0.8	0.8	0.1
Supplements: Glucosamine	0.1	0.2	0.3	-0.1	0.4	-0.4	-0.6
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	7.3	-1.2	1.3	-1.5	-2.7
Medication: Atenolol	1.0	1.3	3.0	-1.7	-0.7	-1.0	-0.9
Medication: Levothyroxine sodium	0.7	1.2	2.9	0.8	-1.7	1.2	-0.2
Sitting height	3.0	21.6	40.6	-1.2	2.1	-6.3	-6.4
Chronic bronchitis/emphysema (father)	0.3	0.4	1.1	-0.5	1.0	0.1	-0.4
High blood pressure (mother)	0.6	0.9	1.7	-1.1	-0.7	0.1	1.3
Body mass index (BMI)	0.9	3.7	6.9	1.0	-1.9	2.6	1.8
Impedance of leg (left)	2.3	11.2	25.1	-1.3	1.3	-4.0	-5.0
Leg predicted mass (left)	0.0	0.2	0.7	0.1	-0.2	-0.1	-0.9
Trunk fat mass	0.7	3.0	10.2	0.3	-0.0	-1.4	-3.2
Waist circumference	0.5	1.7	5.8	0.3	-0.7	-0.6	-2.4
Number of incorrect matches in round	0.8	1.4	3.1	-1.8	1.1	-0.5	-0.9
Past tobacco smoking	2.2	4.0	7.9	0.6	-2.8	1.8	2.1
Alcohol usually taken with meals	0.5	0.8	1.2	-1.1	1.0	-0.6	-0.8
Nervous feelings	0.6	1.2	2.5	1.6	-1.0	-0.8	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	-0.7	-1.2	-0.1	-0.7
Hearing difficulty/problems with background noise	1.0	1.5	5.9	0.3	0.3	2.4	0.2
Hair/balding pattern: Pattern 2	0.7	0.9	1.7	-1.3	0.3	-1.1	-0.8
Had menopause	1.7	2.1	6.2	0.5	2.5	-0.4	-1.4
Had other major operations	0.4	0.5	0.8	0.8	-0.1	0.7	0.9
Forced vital capacity (FVC)	0.2	0.9	1.7	1.2	1.3	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.3	-0.5	-1.1	0.3	1.5
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	4.6	0.5	-1.2	2.1	2.0
Qualifications: None of the above	2.0	4.2	9.1	-0.9	0.2	-3.0	-2.6
Financial difficulties in last 2 years	1.6	2.1	6.7	1.2	-2.6	0.4	0.6
Mouth/teeth dental problems	0.6	0.9	1.8	-0.6	-1.3	-0.9	-0.9
Heart attack	1.5	1.9	3.5	0.8	-0.6	1.9	1.7
Allergy	1.1	2.5	5.1	-0.3	-0.6	-2.2	-2.1
Pain all over the body in last month	2.8	3.0	7.0	0.5	-1.8	2.6	1.4
Diabetes (self-reported)	0.4	0.7	1.4	-0.3	-0.4	-1.2	-1.0
Hayfever/allergic rhinitis (self-reported)	3.9	5.2	9.9	0.9	-1.0	3.1	3.0
Medication: Ramipril	2.1	2.7	5.6	1.1	-1.5	1.4	2.4
Medication: Simvastatin	0.2	0.3	0.5	0.5	-0.0	-0.7	-0.7
Fluid intelligence score	0.5	1.0	3.3	-0.6	1.8	0.7	-0.1
Illnesses of siblings	0.5	0.7	1.4	1.2	1.0	0.8	0.0
Neuroticism score	0.6	1.3	4.8	2.2	-0.4	-0.1	-0.4
Weight	0.2	1.0	3.8	0.1	-0.3	-0.2	-1.9
Impedance of arm (right)	3.0	13.9	26.7	-1.2	2.8	-4.4	-5.2
Arm fat percentage (right)	0.1	0.6	0.8	0.6	-0.7	0.9	-0.8
Trunk fat-free mass	0.0	0.2	0.6	-0.2	0.1	0.2	-0.7
Hip circumference	0.2	0.8	2.5	0.2	-0.8	-0.1	-1.6
Time employed in main current job	2.2	2.6	10.3	3.2	0.0	0.0	0.1
Alcohol intake versus 10 years previously	0.6	0.9	1.4	-1.2	-1.1	-0.8	-0.8
Father’s age at death	0.1	0.1	0.1	-0.4	-0.2	0.1	0.3
Worrier / anxious feelings	1.6	3.1	6.8	2.1	-0.3	2.6	1.0
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	5.3	2.1	-2.2	2.3	1.4
Falls in the last year	0.7	1.0	2.5	0.5	1.6	0.3	-1.1
Hair/balding pattern: Pattern 3	0.5	0.7	1.7	1.1	-1.3	-0.2	0.0
Number of live births	1.0	1.3	2.6	0.8	0.7	-1.3	-1.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.4	1.9	0.9	-0.3	0.4
Pulse rate	0.8	1.4	4.3	-0.9	2.1	0.4	-0.5
Happiness	1.6	2.0	5.2	-0.3	0.8	2.3	1.4
Noisy workplace	0.2	0.2	0.5	0.3	0.7	0.4	0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.4	-0.5	1.0	1.2	1.1
Serious illness, injury or assault of a close relative in last 2 years	3.6	4.1	8.3	-1.0	1.1	-2.9	-2.4
Mouth/teeth dental problems: Dentures	0.8	1.3	2.7	-0.3	0.9	1.6	1.3
Asthma	0.6	1.3	3.2	-0.3	-0.9	1.8	1.0
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.6	5.3	2.3	-0.5	1.8	1.2
Medication: Cholesterol lowering	0.9	1.4	3.1	-0.6	-1.8	0.6	1.2
Depression (self-reported)	0.3	0.4	1.2	0.1	-0.5	1.1	0.2
Medication: Lansoprazole	1.8	2.0	4.2	1.6	-2.0	1.1	0.3
Prospective memory result	0.8	1.0	2.0	-1.0	0.2	-0.9	-1.4
Lung cancer (father)	0.7	0.9	2.3	-0.3	-1.5	0.0	1.0
Illnesses of mother	0.3	0.4	1.4	1.2	-0.3	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.2	1.5	1.0	0.5	0.8
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.6	0.1	-0.7	0.5
Impedance of arm (left)	3.3	15.4	30.7	-1.3	2.7	-4.7	-5.5
Arm fat mass (right)	0.1	0.6	1.0	0.3	-0.8	0.7	-1.0
Trunk predicted mass	0.0	0.2	0.5	-0.2	0.1	0.2	-0.7
Standing height	3.1	30.9	69.2	-2.1	3.4	-6.2	-8.3
Length of working week for main job	1.6	1.8	4.3	1.0	-0.4	1.3	2.1
Exposure to tobacco smoke at home	1.2	1.3	2.8	-1.0	0.3	-1.7	-1.2
Breastfed as a baby	0.2	0.3	0.6	-0.1	0.6	-0.3	-0.8
Tense / ‘highly strung’	0.1	0.2	0.9	-0.1	-0.9	0.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	2.8	-0.2	-1.7	1.7	1.2
Hair/balding pattern: Pattern 4	0.1	0.1	0.2	-0.3	0.1	0.4	-0.5
Birth weight of first child	0.2	0.4	0.6	-0.6	0.8	0.5	-0.8
Peak expiratory flow (PEF)	0.3	0.7	1.4	1.1	-0.2	0.3	1.2
Pulse wave reflection index	0.7	0.9	1.9	-1.4	-0.3	-0.4	1.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.6	-1.3	-1.1	0.1	0.2
Loud music exposure frequency	0.2	0.3	0.8	-0.1	-0.9	0.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	0.1	-0.4	-0.1	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.4	0.9	1.5	-0.2	0.1
Blood clot in the leg (DVT)	1.2	1.5	3.0	-1.0	-0.5	-1.7	-1.3
Medication: Paracetamol	0.4	0.7	2.6	1.6	-0.4	0.1	0.3
Headache pain in last month	0.6	1.1	2.3	0.1	-1.3	0.6	1.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.6	-0.3	0.8	-0.6	-1.3
Glaucoma (self-reported)	1.1	1.3	4.8	-0.0	-0.5	0.3	2.2
Gout (self-reported)	0.4	0.6	1.5	-1.2	-0.2	-0.3	-0.9
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	5.1	0.5	-2.3	1.0	0.1
Medication: Amlodipine	1.4	2.0	3.2	-1.5	0.8	-1.8	-1.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.9	-0.7	-0.1	-0.2
Birth weight	1.1	2.4	4.7	0.5	0.9	-1.9	-2.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.7	-0.7	-0.6	0.8	0.6
High blood pressure (siblings)	0.4	0.6	1.8	-0.6	-1.3	-0.1	0.5
Forced vital capacity (FVC), Best measure	0.1	0.5	1.5	0.7	1.2	-0.2	0.0
Body fat percentage	0.4	1.6	5.4	0.3	-0.7	-0.7	-2.3
Leg fat percentage (right)	0.4	1.3	3.7	0.4	-1.9	1.1	-0.3
Arm fat-free mass (right)	0.1	0.4	1.2	-0.4	-0.5	-0.3	-1.1
Exposure to tobacco smoke outside home	0.9	1.2	2.7	-0.8	-1.6	-1.0	-0.6
Comparative body size at age 10	0.9	2.4	4.9	0.3	0.9	2.2	2.0
Number of full brothers	0.4	0.5	1.2	0.5	-1.1	0.2	0.7
Worry too long after embarrassment	1.1	1.9	5.9	2.4	-0.9	0.7	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	1.8	1.3	-1.0	0.9	1.3
Wheeze or whistling in the chest in last year	0.4	0.6	1.3	-0.2	-1.1	1.1	0.1
Number of children fathered	0.2	0.3	0.4	-0.0	0.6	-0.6	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	0.0	-0.1	-0.8	-0.5
Age at first live birth	1.7	3.1	5.2	1.7	2.3	1.6	1.4
Pulse wave peak to peak time	0.3	0.3	1.0	0.3	0.2	0.4	-1.0
Health satisfaction	0.6	0.8	2.6	1.6	0.3	-0.5	-0.5
Shortness of breath walking on level ground	0.2	0.2	0.5	0.3	0.7	0.1	-0.4
Qualifications: College or University degree	1.7	5.3	7.9	1.3	2.5	2.8	2.3
Eye problems/disorders: None of the above	1.8	2.0	4.0	0.2	-1.1	-2.0	-1.7
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.3	0.1	0.1	-0.1
Emphysema/chronic bronchitis	0.1	0.2	0.4	0.4	0.6	0.0	0.3
Medication for pain relief, constipation, heartburn	2.0	3.4	7.7	-2.8	0.7	-1.9	-1.4
Neck or shoulder pain in last month	1.1	1.6	4.2	2.0	-0.5	0.7	1.2
Medication: Blood pressure	0.3	0.5	1.4	-0.4	-0.6	0.1	1.2
Angina (self-reported)	0.3	0.5	1.0	-0.1	-1.0	0.3	0.8
Migraine (self-reported)	3.7	4.5	5.8	2.4	-1.6	2.2	2.2
Medication: Ibuprofen	4.1	4.9	9.8	3.1	-0.7	2.5	1.6
Medication: Allopurinol	1.3	1.8	2.9	-1.2	0.5	-1.5	-1.7
Medication: Omeprazole	0.4	0.4	1.6	0.0	-0.2	-0.3	-1.3
Medication: Seretide 50 evohaler	0.3	0.4	1.3	-1.1	0.4	-0.2	0.1
Mean time to correctly identify matches	0.0	0.0	0.0	0.1	0.0	-0.0	-0.2
Heart disease (mother)	0.8	0.9	1.7	-0.1	-1.2	0.7	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	4.3	1.3	-2.1	-0.9	-0.5
Whole body fat mass	0.3	1.3	4.6	0.3	-0.4	-0.6	-2.1
Leg fat mass (right)	0.2	0.7	1.3	0.6	-1.2	0.6	-0.8
Arm predicted mass (right)	0.1	0.4	1.0	-0.5	-0.5	-0.3	-1.0
Pulse rate, automated reading	0.3	1.0	2.4	0.4	1.6	0.7	-1.0
Alcohol intake frequency.	0.4	1.0	3.7	-0.4	-1.9	0.3	-0.2
Comparative height size at age 10	0.7	3.6	9.1	0.1	1.4	-1.9	-3.0
Number of full sisters	0.4	0.5	1.6	-0.2	-1.3	0.3	-0.4
Suffer from ‘nerves’	0.3	0.5	1.5	1.2	-0.1	-0.5	-0.6
Overall health rating	0.4	0.8	2.3	-0.0	-1.5	0.7	-0.6
Chest pain or discomfort	0.8	1.1	1.9	-0.8	-1.2	-0.8	-1.4
Had major operations	0.9	1.1	3.2	-0.3	-1.0	0.2	1.8
Age at last live birth	0.9	1.3	2.3	1.3	0.7	0.9	1.5
Family relationship satisfaction	2.9	3.6	5.9	-2.4	0.6	1.9	2.1
Leg pain on walking	1.9	2.3	7.4	2.7	1.2	0.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	0.1	-0.5	0.5	0.8
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.4	-0.3	-1.6	0.9	1.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.8	0.4	0.5	-0.1
Medication: Aspirin	1.1	1.5	2.4	0.2	-1.2	1.5	1.5
Supplements: Vitamin C	1.2	1.4	3.7	-0.6	0.4	-1.2	-1.9
Knee pain experienced in last month	0.4	0.7	1.0	0.9	0.7	-0.6	-1.0
Hypertension (Self-reported)	0.2	0.5	1.2	-0.5	-0.5	0.3	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.0	-0.4	-0.7	-0.4	-1.4
Illnesses of father: Heart disease	1.3	1.8	4.3	1.5	-0.7	2.1	0.4
Illnesses of siblings: Diabetes	0.6	0.7	1.2	-0.4	1.1	-0.7	-1.0
Smoking status: Previous	1.6	2.5	5.5	-0.7	2.3	-1.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	6.9	-0.9	-0.3	-2.2	-2.6
Whole body fat-free mass	0.0	0.2	0.9	-0.1	-0.2	-0.1	-1.0
Leg fat-free mass (right)	0.0	0.3	0.8	0.0	-0.3	-0.4	-0.9
Arm fat percentage (left)	0.2	0.7	0.9	0.7	-0.9	0.9	-0.7
Average weekly red wine intake	1.3	1.8	3.5	0.7	1.9	1.5	1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	-0.6	1.0	-1.0	-0.6
Mood swings	0.6	1.0	2.2	0.9	0.5	-0.9	-1.5
Loneliness, isolation	2.2	3.1	5.4	0.1	-2.3	1.9	1.8
Long-standing illness, disability or infirmity	0.9	1.4	2.8	-0.5	-1.7	1.4	0.9
Ever had bowel cancer screening	2.0	2.3	6.6	0.7	2.6	-1.0	-1.0
Diabetes diagnosed by doctor	0.8	1.2	1.8	-1.1	-0.4	-1.3	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.0	-0.3	-1.4	0.2	0.5
Friendships satisfaction	0.7	0.9	1.6	-0.8	-0.6	1.0	1.3
Qualifications: nursing, teaching	1.1	1.8	6.8	-0.3	2.6	0.0	-0.4
Commuting to job workplace: Walk	1.5	1.6	5.7	0.3	2.4	-0.5	-0.6
Eye problems/disorders: Cataract	0.6	0.7	1.6	0.3	0.0	1.1	1.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	0.0	0.3	0.0	1.0
Medication for cholesterol	0.6	1.0	2.3	1.5	1.1	-0.5	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	3.5	1.6	-1.2	1.9	1.4
Back pain experienced in last month	0.5	0.7	1.5	1.2	-0.2	1.1	0.3
Mineral and other dietary supplements	0.1	0.2	0.5	0.3	-0.7	-0.3	-0.2
Breast cancer (self-reported)	0.3	0.3	0.6	0.8	0.2	0.8	-0.0
Asthma (self-reported)	0.6	1.2	3.5	-0.1	-0.6	1.9	1.0
Osteoporosis (self-reported)	1.3	1.6	4.9	-2.2	0.1	-0.7	-1.0
Osteoarthritis (self-reported)	0.3	0.4	0.7	0.7	-0.2	0.8	0.5
Medication: Aspirin	1.3	1.7	3.0	-0.2	-1.5	1.3	1.7
Medication: Gliclazide	1.3	1.4	2.8	-0.7	1.7	-0.9	-1.2
Illnesses of father: None of the above (group 1)	3.0	3.7	5.5	-2.1	2.3	-1.9	-1.3
Smoking status: Current	0.6	1.0	2.9	-0.2	-0.2	0.9	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	7.7	2.5	1.0	0.3	2.8
Whole body water mass	0.0	0.2	0.7	-0.0	-0.2	0.1	-0.8
Leg predicted mass (right)	0.1	0.3	0.8	0.1	-0.4	-0.4	-0.9
Arm fat mass (left)	0.1	0.6	0.8	0.5	-0.8	0.9	-0.8
Number of self-reported non-cancer illnesses	1.5	2.6	6.4	1.3	-0.8	2.5	1.2
Average weekly champagne plus white wine intake	0.2	0.3	0.8	0.2	0.4	-0.4	-0.9
Miserableness	1.4	2.4	3.6	1.9	0.9	-1.7	-1.5
Guilty feelings	0.3	0.4	0.8	0.9	-0.7	0.1	0.5
Wears glasses or contact lenses	1.9	2.2	3.0	1.6	0.8	1.7	1.6
Ever taken oral contraceptive pill	4.2	4.7	9.1	3.0	-1.3	2.3	1.7
Hearing aid user	1.4	1.6	3.7	-1.9	-0.2	1.1	1.2
Mother’s age at death	0.4	0.5	1.2	-0.1	1.1	-0.5	-0.6
Financial situation satisfaction	0.5	0.6	2.2	0.4	-1.5	-0.0	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	-0.4	-0.1	-0.8	-0.4
Commuting to job workplace: Public transport	0.2	0.3	1.0	0.4	1.0	0.1	-0.1
Eye problems/disorders: Glaucoma	0.6	0.7	2.4	-0.3	-0.4	0.2	1.6
Medication: Blood pressure	0.4	0.8	2.2	-1.5	-0.3	0.9	0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.4	1.2	0.9	0.6	0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.7	0.5	0.0	0.6	0.9
High cholesterol (Self-reported)	0.4	0.7	2.7	-1.6	-0.5	0.0	-0.0
Medication: Bendroflumethiazide	0.4	0.6	1.8	0.4	0.7	1.3	0.1
Medication: Paracetamol	0.5	0.8	2.8	1.7	-0.1	0.5	0.1
Medication: Lisinopril	0.1	0.1	0.2	-0.4	0.1	-0.3	-0.5
Medication: Atorvastatin	2.7	3.3	10.2	-3.2	-1.7	-0.5	-0.1
Illnesses of father: High blood pressure	1.3	1.6	3.5	0.6	-1.2	0.9	1.9
Alcohol drinker status: Never	0.6	0.8	2.0	0.6	-1.4	0.6	0.5
Ever smoked	2.4	4.3	7.0	-0.9	2.6	-1.8	-2.4
Basal metabolic rate	0.1	0.4	1.5	-0.2	-0.2	-0.1	-1.2
Leg fat percentage (left)	0.4	1.4	4.1	0.6	-2.0	0.8	-0.6
Arm fat-free mass (left)	0.1	0.4	1.0	-0.1	-0.6	0.2	-1.0
Number of operations (self-reported)	0.7	1.0	2.3	0.3	-1.2	0.1	1.5
Average weekly beer plus cider intake	0.9	1.3	3.5	1.0	-1.9	0.3	0.7
Irritability	0.1	0.2	0.4	0.4	0.1	0.6	-0.3
Risk taking	0.2	0.2	0.7	-0.4	0.8	-0.2	-0.3
Ever had prostate specific antigen (PSA) test	0.8	1.0	3.6	-1.9	0.4	-0.2	-0.4
Fractured/broken bones in last 5 years	0.6	0.8	1.9	-0.6	1.4	0.7	-0.7
Age started oral contraceptive pill	0.7	0.9	1.9	0.9	-0.6	-1.4	-0.8
Diastolic blood pressure, automated reading	0.4	1.1	2.3	-0.0	0.6	1.3	1.5
Ever depressed for a whole week	3.1	3.8	6.3	1.9	-0.6	2.5	2.2
Unable to work because of sickness or disability	1.3	1.6	3.9	-0.9	-2.0	1.3	0.5
Commuting to job workplace: Cycle	0.3	0.4	1.0	-0.6	1.0	-0.4	0.1
Myopia	1.7	2.5	7.0	2.6	-1.4	-0.3	1.1
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.2	1.1	0.3	-0.3	-0.6
Cholesterol lowering medication	1.3	1.8	5.1	-2.3	-0.4	-0.5	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	-0.7	0.1	-0.4	-1.2
Pain experienced in last month	0.8	1.3	2.7	-1.6	0.1	-1.1	-1.1
Supplements: Calcium	0.4	0.5	1.7	0.1	1.3	0.3	0.1
Basal cell carcinoma (self-reported)	0.4	0.5	0.8	0.3	0.9	0.8	0.7
Heart attack/myocardial infarction (self-reported)	1.6	2.1	3.9	1.2	-0.5	2.0	1.7
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	3.4	-0.6	-0.6	-1.9	-1.5
Heart disease (siblings)	0.1	0.1	0.2	-0.5	-0.2	-0.0	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.4	-0.2	0.3	0.6	0.1
Pack years of smoking	1.1	1.6	3.9	-2.0	-0.9	1.3	0.3
Impedance of whole body	2.8	14.5	31.6	-1.2	2.0	-4.6	-5.6
Leg fat mass (left)	0.2	0.8	1.5	0.8	-1.2	0.4	-1.0
Arm predicted mass (left)	0.1	0.3	0.8	-0.5	-0.6	0.1	-0.9