TWAS hub - CREB5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2580	0.0610	6.3e-05	0.199	NA	0.168	NA	0.199	7.2e-15	NA	1.2e-12	NA	6.9e-15
2	NTR	Blood	0.0750	0.0194	9.7e-06	0.060	0.019	0.067	0.055	0.063	1.0e-18	6.5e-07	7.7e-21	3.6e-17	1.1e-19
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0915	0.0356	1.7e-03	0.007	0.027	0.004	NA	0.006	4.6e-02	4.5e-04	9.3e-02	NA	6.7e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood White Count	19.9	147.8	441.0	1.5	-21.0	0.3
Noisy workplace	3.4	4.2	8.6	-1.8	2.9	0.8
Osteoporosis (self-reported)	3.1	3.9	9.1	1.6	-0.0	-3.0
Alcohol drinker status: Never	3.1	3.7	5.1	-1.1	-2.2	2.3
Breast Cancer	2.7	6.5	18.5	-4.3	-0.9	0.4
Tense / ‘highly strung’	2.7	4.6	7.0	1.1	2.6	-2.4
Alcohol intake frequency.	2.6	6.0	13.3	-0.8	-3.6	2.0
Medication: Atorvastatin	2.6	3.2	3.8	-1.9	1.9	-1.5
Ever depressed for a whole week	2.6	3.2	6.2	2.5	-1.2	-1.3
Medication: Seretide 50 evohaler	2.4	2.8	3.9	-2.0	1.0	1.9
Chronic bronchitis/emphysema (mother)	2.3	2.6	5.2	-1.1	-2.3	-1.2
Rheumatoid Arthritis	2.2	3.0	5.6	-1.2	2.4	1.4
Eye problems/disorders: None of the above	2.2	2.6	6.1	0.9	0.9	-2.5
Leg pain on walking	2.2	2.8	5.0	-2.2	-1.8	0.1
Systolic Blood Pressure	2.0	9.9	23.6	-2.3	-0.9	-4.9
Depression (self-reported)	2.0	2.3	6.6	0.2	2.6	0.6
Depression (Nagel 2018)	1.9	2.8	8.4	0.3	2.9	-0.3
Eye problems/disorders: Glaucoma	1.9	2.2	6.2	0.1	-2.5	0.6
Schizophrenia (2014)	1.8	4.0	11.8	0.3	0.1	-3.4
Allergy	1.8	4.1	10.6	3.3	0.9	-0.8
Illnesses of father: None of the above (group 1)	1.8	2.3	4.8	-0.2	-2.2	1.4
Medication: Co-codamol	1.7	2.0	2.9	-1.3	-1.1	1.7
High blood pressure	1.7	4.6	11.6	0.4	-1.5	-3.4
Age at first live birth	1.7	3.1	8.1	0.8	2.9	0.7
Wheeze or whistling in the chest in last year	1.6	2.9	8.2	-2.9	-0.6	-0.3
Shortness of breath walking on level ground	1.6	1.9	4.9	-0.9	-2.2	0.1
Length of working week for main job	1.5	1.7	3.6	-1.0	-1.9	0.6
Breastfed as a baby	1.5	1.8	3.8	-0.5	-1.2	1.9
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	5.4	2.3	0.3	-0.5
Suffer from ‘nerves’	1.5	2.4	5.2	0.7	2.3	-1.2
Age at last live birth	1.5	2.1	5.1	2.3	1.0	-0.5
Hypertension (Self-reported)	1.5	4.2	9.9	0.3	-1.6	-3.1
Illnesses of father: High blood pressure	1.5	1.9	2.8	-0.1	1.7	-1.7
Frequency of depressed mood in last 2 weeks	1.4	2.0	5.4	-0.3	2.3	-0.6
Taking other prescription medications	1.4	2.1	2.6	-1.6	1.5	1.2
Exposure to tobacco smoke at home	1.4	1.6	4.1	0.3	-2.0	0.7
Medication: Amlodipine	1.4	2.0	4.0	-2.0	0.9	-1.0
Eye problems/disorders: Cataract	1.4	1.7	3.9	-1.0	0.1	2.0
Medication: Lisinopril	1.4	1.8	4.2	-2.1	0.3	1.1
Intelligence (Savage-Jansen 2018)	1.3	4.0	4.9	-1.5	2.2	2.2
Reaction Time	1.3	2.5	6.4	2.5	-0.8	0.7
Severe depression (siblings)	1.3	1.5	2.4	-1.6	1.4	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.8	5.3	-2.3	1.8	0.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.2	-0.1	-1.1	1.8
Had other major operations	1.3	1.5	3.3	1.8	0.4	-1.1
Glaucoma (self-reported)	1.3	1.5	2.8	0.9	-1.7	1.0
Supplements: Vitamin C	1.3	1.6	2.2	0.9	-1.3	-1.5
Ever had prostate specific antigen (PSA) test	1.3	1.5	1.8	-1.0	1.4	1.2
Systolic blood pressure, automated reading	1.2	3.5	5.2	-2.3	-1.0	-2.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.1	-0.9	-1.2	-1.4
Hair/balding pattern: Pattern 4	1.2	2.9	4.2	-2.0	0.4	-2.0
Gout (self-reported)	1.2	1.6	4.7	0.1	0.3	2.2
Medication: Blood pressure	1.2	2.2	3.6	-0.2	-1.9	-1.7
Illnesses of father: Heart disease	1.2	1.6	4.1	-0.7	2.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	4.1	-1.3	1.4	-2.0
Back pain experienced in last month	1.2	1.7	2.9	-0.1	-1.7	1.5
Mother’s age at death	1.2	1.5	3.5	0.8	1.9	0.7
Financial situation satisfaction	1.2	1.5	2.4	-0.3	-1.6	-1.4
Basal cell carcinoma (self-reported)	1.2	1.4	3.4	-0.7	-1.8	0.5
Schizophrenia vs Biploar Disorder	1.1	1.4	3.7	0.4	-0.7	-1.9
Worry (Nagel 2018)	1.1	2.3	3.1	1.4	1.3	-1.8
Neuroticism (2016)	1.1	1.5	2.9	0.6	1.7	-1.1
Hayfever, allergic rhinitis or eczema	1.1	2.4	5.4	-2.3	-1.3	-0.1
Asthma	1.1	2.1	5.8	-2.4	0.3	0.7
Lung cancer (father)	1.1	1.3	2.5	0.2	-1.1	1.6
Birth weight of first child	1.1	1.9	3.3	1.0	1.2	-1.8
Pulse wave reflection index	1.1	1.4	3.1	-0.7	1.8	0.7
Leg fat percentage (right)	1.1	4.0	5.5	-1.3	-2.2	2.3
Number of children fathered	1.1	1.3	1.6	-1.1	-1.2	1.1
Migraine (self-reported)	1.1	1.4	2.6	-1.6	1.1	0.6
Ever had bowel cancer screening	1.1	1.3	2.4	1.0	0.7	1.6
Tinnitus: Yes, now most or all of the time	1.1	1.2	1.5	-1.0	-1.2	1.1
Vascular/heart problems diagnosed by doctor	1.1	3.0	7.1	-0.5	1.3	2.7
Alzheimer’s Disease (including proxy)	1.0	1.4	2.5	-1.1	-0.8	1.6
Supplements: Glucosamine	1.0	1.4	3.9	0.3	2.0	-0.2
Forced vital capacity (FVC)	1.0	4.0	9.6	-1.2	3.1	-1.0
Diabetes (self-reported)	1.0	1.5	4.5	-2.1	0.3	-0.2
Illnesses of siblings	1.0	1.3	2.5	1.2	0.1	1.6
Neuroticism score	1.0	2.1	4.8	0.7	2.2	-1.0
Time employed in main current job	1.0	1.1	1.8	-1.3	-1.2	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.5	1.9	-0.2	-1.1
Pulse wave Arterial Stiffness index	1.0	1.1	3.3	-1.8	0.2	-0.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.5	0.1	-1.9	-0.0
Worry too long after embarrassment	1.0	1.7	2.1	1.5	1.3	-1.2
Medication: Allopurinol	1.0	1.3	2.3	0.0	1.3	1.5
Had major operations	1.0	1.2	3.3	-0.6	-0.0	1.8
Knee pain experienced in last month	1.0	1.6	3.5	-0.3	1.9	-1.1
Illnesses of siblings: Diabetes	1.0	1.2	3.4	-1.9	-0.2	0.3
Qualifications: nursing, teaching	1.0	1.6	2.6	-0.8	-1.6	1.3
Average weekly champagne plus white wine intake	1.0	1.4	2.2	-0.3	-1.5	1.4
Leg fat percentage (left)	1.0	3.6	5.4	-1.3	-2.3	1.9
Neuroticism (Nagel 2018)	0.9	2.0	2.8	1.7	1.3	-1.3
Schizophrenia (2018)	0.9	1.8	5.0	0.1	-0.6	-2.2
Verbal and Numeric Reasoning (VNR)	0.9	2.1	5.0	-0.4	2.2	1.0
Fasting Glucose	0.9	1.0	2.1	0.9	0.3	-1.5
Lupus	0.9	1.4	3.0	0.4	1.7	-1.0
Cardiovascular Disease	0.9	2.8	8.1	-0.2	-0.6	-2.9
Neuroticism	0.9	2.1	3.3	1.6	1.8	-0.8
Supplements: Zinc	0.9	1.0	2.1	-0.7	0.7	-1.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.5	1.6	0.6	0.5
Had menopause	0.9	1.1	2.9	-1.7	-0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.8	-1.9	0.7	1.3
Pain all over the body in last month	0.9	1.0	2.3	-1.5	0.6	0.5
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.7	-1.3	0.2	1.3
Exposure to tobacco smoke outside home	0.9	1.3	1.7	0.7	-1.3	-1.3
Smoking status: Previous	0.9	1.4	3.4	0.3	0.9	-1.8
Friendships satisfaction	0.9	1.1	1.8	1.0	0.6	-1.3
Ever smoked	0.9	1.5	3.1	1.0	-0.7	-1.8
Age started oral contraceptive pill	0.9	1.1	1.7	1.2	0.5	1.3
Bipolar Disorder (2018)	0.8	1.3	2.2	-0.8	1.5	1.1
Alzheimer’s Disease (in father)	0.8	0.9	2.2	-1.5	-0.5	-0.5
Townsend deprivation index at recruitment	0.8	1.2	3.2	-0.5	-1.8	-0.3
Sitting height	0.8	5.4	8.1	-0.1	2.8	-2.8
Nervous feelings	0.8	1.4	2.9	0.8	0.9	-1.7
Financial difficulties in last 2 years	0.8	1.0	1.8	-1.4	-0.9	0.6
Falls in the last year	0.8	1.1	2.5	0.0	0.8	-1.6
Peak expiratory flow (PEF)	0.8	1.8	4.8	-2.2	0.6	0.4
High blood pressure (siblings)	0.8	1.2	2.7	-1.6	-0.9	-0.3
Number of full brothers	0.8	1.0	2.4	-0.8	-1.5	-0.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.6	0.2	-0.0	-1.6
Average weekly red wine intake	0.8	1.2	2.6	-1.6	-0.3	-1.0
Pain experienced in last month	0.8	1.3	2.3	1.5	-0.5	-1.1
Alcohol drinker status: Previous	0.8	0.9	2.6	-0.3	-1.6	-0.3
Bipolar Disorder (2011)	0.7	0.7	1.1	-0.8	-0.4	1.1
Crohns Disease (2012)	0.7	1.1	1.3	-1.1	-0.9	1.1
Height	0.7	13.7	24.8	-1.1	3.9	-5.0
Allergy or Eczema	0.7	1.8	3.4	-1.8	-1.1	-0.9
Respiratory disease	0.7	1.5	4.0	-2.0	-0.4	-0.6
Multivitamins +/- minerals	0.7	0.9	2.2	0.3	1.5	-0.7
Alcohol usually taken with meals	0.7	1.1	2.2	0.0	-1.5	-1.0
Medication: Ramipril	0.7	0.9	1.4	0.6	-1.2	-0.9
Hair/balding pattern: Pattern 3	0.7	1.1	2.4	0.1	-1.5	1.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.5	-1.2	2.1	-0.9
Medication: Lansoprazole	0.7	0.8	2.0	0.4	1.4	0.5
Standing height	0.7	6.8	10.4	-1.8	2.6	-3.2
Forced vital capacity (FVC), Best measure	0.7	2.5	4.0	-1.3	2.0	-1.2
Pulse wave peak to peak time	0.7	0.8	2.4	1.6	-0.2	0.0
Medication: Omeprazole	0.7	0.9	1.7	-0.1	-1.0	-1.3
Mean time to correctly identify matches	0.7	1.3	2.9	1.7	-0.5	0.9
Number of full sisters	0.7	0.9	1.6	-1.2	-1.0	0.1
Commuting to job workplace: Walk	0.7	0.8	1.2	0.8	-0.7	1.1
Asthma (self-reported)	0.7	1.4	3.7	-1.9	0.3	0.7
Commuting to job workplace: Public transport	0.7	0.8	1.9	-0.1	-0.8	1.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.4	-1.5	0.5	0.4
Myopia	0.7	1.0	1.9	0.9	0.4	1.4
Depressed Affect (Nagel 2018)	0.6	1.2	2.4	1.6	0.9	-0.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	0.2	0.8	1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.8	-1.4	0.0	0.3
Lung FEV1/FVC ratio	0.6	2.8	7.7	0.8	-2.8	0.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.2	-0.9	0.3	1.1
Fed-up feelings	0.6	1.1	2.8	-0.1	0.8	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.0	0.6	1.4	0.1
Serious illness, injury or assault to yourself	0.6	0.7	1.1	1.0	-0.2	1.0
Number of incorrect matches in round	0.6	1.1	3.0	-0.4	-1.7	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.3	-1.1	1.0	-0.6
Hearing difficulty/problems with background noise	0.6	1.0	2.3	1.5	0.2	-0.8
Alcohol intake versus 10 years previously	0.6	0.9	1.3	0.6	-1.1	0.9
Worrier / anxious feelings	0.6	1.1	2.5	0.7	1.6	-0.6
Number of live births	0.6	0.9	1.5	1.2	-0.9	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.4	1.2	0.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	1.2	0.9	-0.4
Leg fat mass (right)	0.6	2.3	2.7	-1.4	-1.5	1.6
Comparative height size at age 10	0.6	3.2	5.5	-0.0	2.3	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.6	1.1	0.3	0.9	-1.0
Medication: Gliclazide	0.6	0.7	1.8	-1.3	-0.3	-0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.5	-0.8	-0.3	-1.2
Fractured/broken bones in last 5 years	0.6	0.8	1.9	1.4	-0.3	0.6
Commuting to job workplace: Cycle	0.6	0.8	1.2	-0.9	1.1	0.6
Cholesterol lowering medication	0.6	0.9	1.3	-0.7	1.1	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.1	-0.5	-1.0	-1.0
Coronary Artery Disease (CAD)	0.5	0.5	1.6	0.1	0.1	1.3
Mean Putamen Volume	0.5	0.5	1.3	1.1	0.6	-0.1
Triglycerides	0.5	0.8	2.3	1.5	0.2	-0.0
Blood Eosinophil Count	0.5	3.5	5.5	-2.2	-2.3	-0.4
Smoking Status	0.5	1.2	2.5	-0.8	0.7	-1.6
Medication for hormone replacement therapy	0.5	0.5	0.6	-0.7	0.8	0.6
Medication: Metformin	0.5	0.7	1.7	-1.3	-0.2	-0.6
Hand grip strength (right)	0.5	1.4	3.9	-2.0	0.2	0.4
Relative age voice broke	0.5	0.8	1.8	1.3	-0.5	-0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.9	0.3	1.0	-0.8
Medication: Levothyroxine sodium	0.5	0.9	1.4	0.9	-0.7	-1.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.2	-1.1	-1.0	-0.1
Fluid intelligence score	0.5	1.1	2.6	0.2	1.6	0.9
Arm fat percentage (right)	0.5	1.8	3.1	-0.0	-1.8	1.5
Father’s age at death	0.5	0.7	2.0	0.2	-1.4	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	-0.4	0.3	-1.3
Medication: Paracetamol	0.5	0.9	1.0	0.9	1.0	-1.0
Body fat percentage	0.5	1.9	3.8	-0.7	-2.0	1.2
Health satisfaction	0.5	0.6	1.7	-1.3	0.4	0.1
Medication: Ibuprofen	0.5	0.6	1.4	1.2	0.6	-0.2
Heart disease (mother)	0.5	0.6	1.0	0.6	-1.0	-0.8
Loneliness, isolation	0.5	0.7	1.6	1.3	-0.2	-0.8
Diabetes diagnosed by doctor	0.5	0.8	2.2	-1.5	0.5	-0.1
Medication: Aspirin	0.5	0.7	1.0	-0.6	-0.8	1.0
Medication: Blood pressure	0.5	0.9	1.5	-0.1	1.1	-1.2
Medication: Bendroflumethiazide	0.5	0.8	2.1	0.6	0.2	-1.4
Medication: Paracetamol	0.5	0.8	1.7	0.5	1.3	-0.7
Risk taking	0.5	0.8	1.3	-0.9	-0.6	1.1
Diastolic blood pressure, automated reading	0.5	1.6	2.1	-1.4	-0.8	-1.4
Unable to work because of sickness or disability	0.5	0.6	1.1	0.6	-1.1	0.6
Leg fat mass (left)	0.5	1.9	2.6	-1.3	-1.6	1.2
Crohns Disease (2017)	0.4	0.9	1.1	-1.1	-0.9	-1.0
Major Depression (MDD)	0.4	0.5	1.3	0.3	-1.1	-0.4
Body Mass Index (BMI) (2010)	0.4	0.6	0.9	-0.2	0.9	0.9
HDL Cholesterol	0.4	0.7	1.6	-0.1	-0.8	1.2
Heel T-Score	0.4	3.4	8.8	-3.0	0.9	0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.9	-1.4	0.6	-0.4
Chronotype (morning person)	0.4	0.9	1.8	-1.3	0.2	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-0.5	-0.1	1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.7	-0.7	-0.8	-0.6
Pack years adult smoking proportion	0.4	0.6	1.2	-0.8	0.0	-1.1
Current tobacco smoking	0.4	0.7	1.4	-1.2	-0.6	-0.4
Maternal smoking around birth	0.4	0.6	1.7	0.2	-0.4	1.3
Stomach or abdominal pain in last month	0.4	0.5	1.2	0.3	-0.6	1.1
Past tobacco smoking	0.4	0.8	2.0	-0.5	-0.2	1.4
Mouth/teeth dental problems	0.4	0.7	0.7	-0.8	-0.8	0.8
Trunk fat-free mass	0.4	2.1	3.3	-1.6	1.8	-0.5
Happiness	0.4	0.5	0.9	-0.5	0.4	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	1.9	-0.7	1.2	-1.4
Trunk predicted mass	0.4	2.0	3.1	-1.7	1.8	-0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.0	0.8	-0.7	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.2	-0.0	0.2	-1.1
Qualifications: College or University degree	0.4	1.2	3.2	-0.6	-0.0	1.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	0.9	-0.2	-0.9
Emphysema/chronic bronchitis	0.4	0.4	0.7	-0.2	0.8	-0.7
Arm fat percentage (left)	0.4	1.6	2.5	0.1	-1.6	1.4
Long-standing illness, disability or infirmity	0.4	0.7	1.8	-1.4	0.4	0.2
Smoking status: Current	0.4	0.7	1.8	-1.4	-0.5	-0.1
Hearing aid user	0.4	0.5	0.7	0.2	0.8	-0.8
Irritability	0.4	0.7	2.1	-0.4	1.4	-0.2
Supplements: Calcium	0.4	0.5	0.7	-0.9	-0.7	0.2
Pack years of smoking	0.4	0.6	1.0	-1.0	0.1	-1.0
Ovarian Cancer	0.3	0.4	0.6	-0.2	0.7	0.8
HbA1C	0.3	0.3	0.7	-0.4	-0.2	0.8
Primary Biliary Cirrhosis	0.3	0.4	0.5	-0.4	-0.7	0.7
Average weekly spirits intake	0.3	0.4	0.6	0.8	-0.7	0.2
Angina	0.3	0.4	0.7	-0.8	-0.3	0.8
Impedance of leg (right)	0.3	1.4	3.2	-1.8	-0.8	0.6
Average weekly fortified wine intake	0.3	0.3	0.5	-0.6	-0.1	-0.7
Qualifications: CSEs or equivalent	0.3	0.3	0.7	0.6	0.1	-0.8
Medication: Atenolol	0.3	0.4	0.9	0.5	0.9	-0.4
High blood pressure (mother)	0.3	0.4	0.6	-0.8	0.7	-0.4
Body mass index (BMI)	0.3	1.4	2.7	-0.6	-1.1	1.6
Impedance of leg (left)	0.3	1.4	2.8	-1.7	-1.1	0.2
Waist circumference	0.3	1.2	2.0	-0.9	-1.4	0.9
Qualifications: None of the above	0.3	0.7	1.1	0.5	-1.0	-0.9
Prospective memory result	0.3	0.4	0.9	0.5	-0.4	-0.9
Headache pain in last month	0.3	0.5	1.3	1.1	0.3	0.2
Medication for pain relief, constipation, heartburn	0.3	0.4	1.2	-1.1	-0.2	0.3
Whole body fat mass	0.3	1.1	1.7	-1.1	-1.3	0.6
Arm predicted mass (right)	0.3	1.5	2.2	-1.5	1.4	-0.5
Chest pain or discomfort	0.3	0.4	0.6	-0.2	-0.7	0.8
Family relationship satisfaction	0.3	0.4	0.6	0.8	0.2	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.5	-0.7	0.1	-0.7
Medication: Aspirin	0.3	0.5	1.1	-0.1	-0.5	1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.7	-0.8	0.7	0.6
Medication for cholesterol	0.3	0.4	0.7	0.8	-0.3	0.6
Mineral and other dietary supplements	0.3	0.5	0.7	0.4	-0.7	0.9
Osteoarthritis (self-reported)	0.3	0.4	1.0	0.2	0.4	1.0
Whole body water mass	0.3	1.5	2.8	-1.3	1.7	-0.5
Miserableness	0.3	0.6	1.2	-0.6	1.1	-0.4
Guilty feelings	0.3	0.4	0.8	0.9	-0.5	-0.3
High cholesterol (Self-reported)	0.3	0.6	1.4	-0.2	1.2	-0.5
Arm fat-free mass (left)	0.3	1.4	2.8	-1.7	1.1	-0.4
Average weekly beer plus cider intake	0.3	0.4	0.9	0.6	-0.2	1.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	-0.8	-0.7	0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	-0.4	0.4	-1.0
LDL Cholesterol	0.2	0.3	0.7	0.8	-0.3	-0.3
Blood Red Count	0.2	1.6	3.3	-1.8	-1.1	-0.6
BMI	0.2	1.1	2.2	-0.3	-1.0	1.5
Lung FVC	0.2	1.0	2.6	0.5	1.6	-0.2
Sensitivity / hurt feelings	0.2	0.4	0.5	0.6	0.7	-0.5
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.9	-0.1	-0.4
Relative age of first facial hair	0.2	0.4	0.9	0.6	-0.0	-0.9
Diabetes (father)	0.2	0.2	0.4	-0.4	0.6	0.4
Trunk fat percentage	0.2	1.0	1.8	-0.8	-1.3	0.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.6	0.4	-0.2
Trunk fat mass	0.2	0.8	1.3	-1.1	-1.1	0.4
Hair/balding pattern: Pattern 2	0.2	0.3	0.3	0.6	0.5	-0.5
Medication: Simvastatin	0.2	0.3	1.0	1.0	0.0	0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	-0.2	0.1	0.9
Arm fat mass (right)	0.2	0.7	1.1	-0.4	-0.9	1.0
Loud music exposure frequency	0.2	0.2	0.3	0.2	0.4	0.6
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.5	-0.8	-0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.4	0.8	0.2
Arm fat-free mass (right)	0.2	1.2	1.8	-1.3	1.3	-0.2
Comparative body size at age 10	0.2	0.6	1.1	0.4	0.8	1.1
Neck or shoulder pain in last month	0.2	0.3	0.9	0.3	-1.0	0.0
Angina (self-reported)	0.2	0.2	0.4	-0.7	-0.1	0.4
Whole body fat-free mass	0.2	1.3	2.0	-1.3	1.4	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	-0.3	-0.8	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.0	-0.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	0.9	0.5	-0.4
Leg predicted mass (right)	0.2	0.8	1.4	-0.3	1.2	-0.9
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.4	-0.2	-0.6
Basal metabolic rate	0.2	1.0	1.6	-1.3	1.1	-0.3
Heart disease (siblings)	0.2	0.3	0.5	0.4	-0.3	-0.7
Arm predicted mass (left)	0.2	1.2	2.5	-1.6	1.1	-0.1
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.3	0.3	0.5
Prostate Cancer	0.1	0.1	0.2	0.2	0.1	0.4
Age at First Birth	0.1	0.1	0.1	-0.3	0.4	0.2
Ulcerative Colitis	0.1	0.1	0.2	0.2	0.2	0.4
Blood Platelet Count	0.1	1.6	3.1	-1.3	-0.3	1.8
Hair Pigment	0.1	2.1	3.3	-1.3	1.0	1.8
Tanning	0.1	1.1	2.5	-0.8	1.6	0.5
Number of treatments/medications taken	0.1	0.2	0.4	-0.7	0.4	-0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.3	0.1	0.6
Vitamin and mineral supplements	0.1	0.2	0.5	-0.7	0.1	-0.0
Diabetes (mother)	0.1	0.1	0.2	-0.3	-0.5	-0.2
Leg fat-free mass (left)	0.1	0.6	1.0	-0.5	1.0	-0.6
Age when periods started (menarche)	0.1	0.2	0.4	-0.6	0.4	-0.4
Leg predicted mass (left)	0.1	0.6	1.1	-0.5	1.0	-0.6
Heart attack	0.1	0.1	0.2	-0.3	0.4	0.2
Weight	0.1	0.5	1.5	-1.2	0.0	0.1
Impedance of arm (right)	0.1	0.4	0.8	-0.0	-0.6	-0.9
Hip circumference	0.1	0.5	0.8	-0.8	-0.9	0.4
Pulse rate	0.1	0.2	0.3	-0.4	-0.5	0.5
Medication: Cholesterol lowering	0.1	0.2	0.5	0.7	-0.0	0.1
Illnesses of mother	0.1	0.1	0.2	0.3	0.3	0.4
Impedance of arm (left)	0.1	0.5	1.2	0.5	-0.2	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.5	-0.0	0.4
Birth weight	0.1	0.2	0.4	0.3	0.4	-0.6
Pulse rate, automated reading	0.1	0.3	0.5	-0.7	-0.3	-0.6
Overall health rating	0.1	0.2	0.4	-0.2	0.3	-0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.1	0.6	0.2
Leg fat-free mass (right)	0.1	0.8	1.2	-0.2	1.1	-1.1
Mood swings	0.1	0.2	0.3	0.6	-0.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.2	0.1	-0.5
Breast cancer (self-reported)	0.1	0.1	0.1	0.2	0.3	-0.1
Arm fat mass (left)	0.1	0.4	0.6	-0.3	-0.8	0.8
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	-0.5	0.1	0.3
Wears glasses or contact lenses	0.1	0.2	0.3	-0.6	-0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	-0.3	0.5	0.2
Impedance of whole body	0.1	0.6	1.0	-0.5	-1.0	-0.7
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	-0.1	-0.2	-0.5
Waist Hip Ratio (WHR)	0.0	0.1	0.1	-0.2	-0.1	0.3
Hypothyroidism (self reported)	0.0	0.0	0.1	0.2	-0.2	-0.2
Hand grip strength (left)	0.0	0.1	0.1	-0.2	0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	-0.5	0.0	-0.2
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.2	0.0	-0.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.1	-0.0	0.4
Number of operations (self-reported)	0.0	0.0	0.1	-0.2	0.2	0.1

Hub : Genes

CREB5

Models

Trait associations