TWAS hub - CRHR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0210	1.2e-03	0.041	0.024	0.042	0.031	0.039	9.0e-06	6.2e-04	6.1e-06	1.1e-04	1.5e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.1130	0.0253	5.4e-10	0.117	0.095	0.101	0.107	0.106	8.3e-15	3.2e-12	6.2e-13	1.3e-13	1.6e-13
3	TCGA	Breast Invasive Carcinoma	0.0924	0.0249	0.0e+00	0.115	0.107	0.111	NA	0.110	1.3e-22	4.6e-21	7.0e-22	NA	9.5e-22
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.1773	0.0426	6.6e-15	0.179	0.133	0.163	NA	0.170	1.0e-19	9.0e-15	5.2e-18	NA	9.7e-19
5	TCGA	Prostate Adenocarcinoma	0.0455	0.0236	4.7e-03	0.002	0.027	0.015	NA	0.012	2.1e-01	6.6e-04	9.5e-03	NA	1.9e-02
6	TCGA	Soft Tissue Sarcoma	0.1310	0.0490	8.3e-05	0.059	0.049	0.054	NA	0.054	2.0e-04	7.2e-04	3.6e-04	NA	3.6e-04
7	TCGA	Thyroid Carcinoma	0.0470	0.0230	6.6e-03	0.003	0.014	0.010	NA	0.012	1.4e-01	1.4e-02	3.5e-02	NA	2.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Emphysema/chronic bronchitis	4.5	5.1	11.2	-0.0	-0.4	-3.3	-3.4	-0.8	-2.6	-2.4
Type 2 Diabetes (T2D) (2012)	4.2	4.8	9.7	-2.5	-3.1	-1.8	-1.3	-2.4	-1.9	-1.9
Mean Putamen Volume	3.9	4.4	8.4	1.2	0.9	-2.7	-2.9	-1.5	-2.7	-1.8
Loneliness, isolation	3.1	4.3	6.9	-1.7	-1.4	-2.6	-2.6	-1.8	-2.3	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.1	11.1	0.9	1.7	3.3	2.8	2.7	2.6	2.4
Medication: Gliclazide	2.7	3.0	5.9	1.6	2.4	1.5	1.2	2.3	1.5	1.3
Diabetes (father)	2.5	3.1	5.7	0.8	-0.0	-2.3	-2.4	-1.3	-2.2	-1.8
Supplements: Vitamin C	2.5	3.0	4.2	1.3	1.9	1.8	1.9	1.7	1.4	2.1
Cardiovascular Disease	2.2	7.2	15.1	-0.4	-0.2	3.5	3.0	2.2	3.9	3.0
Type 2 Diabetes (T2D) (2018)	2.2	4.2	9.2	0.6	0.4	2.3	2.4	1.6	2.5	3.0
Medication: Ibuprofen	2.2	2.6	5.8	0.7	0.9	-2.4	-2.2	-0.9	-1.8	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.7	3.9	-1.4	-1.4	-1.9	-1.7	-1.6	-2.0	-1.5
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	6.8	0.7	0.5	-2.6	-2.3	-1.0	-1.7	-1.3
Average weekly red wine intake	2.1	3.2	5.6	-1.2	-0.1	2.3	2.3	1.1	2.4	1.8
Eye problems/disorders: Cataract	2.1	2.5	8.6	-2.9	-2.1	0.7	0.9	-1.2	1.1	-0.3
Breast cancer (self-reported)	2.1	2.5	4.7	-0.8	-0.8	-1.4	-1.7	-2.2	-1.6	-2.0
Pulse wave Arterial Stiffness index	2.0	2.3	4.1	-1.4	-1.7	1.2	1.6	-0.4	2.0	1.7
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	4.4	-1.1	-1.3	-1.6	-1.7	-1.5	-1.7	-2.1
Comparative body size at age 10	1.9	5.2	11.7	-0.3	-0.0	2.9	2.7	2.1	2.1	3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	4.6	-0.7	-1.0	-2.1	-1.7	-1.8	-1.9	-0.9
Risk taking	1.9	2.8	6.6	-0.8	-0.8	-1.6	-1.5	-2.6	-1.8	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	8.5	-0.1	1.1	2.9	2.4	2.1	1.8	2.3
Shortness of breath walking on level ground	1.8	2.2	4.7	-0.5	0.2	-1.6	-1.6	-2.2	-1.4	-1.9
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	4.5	-0.1	-1.1	-2.1	-2.0	-2.1	-2.1	-1.2
Osteoarthritis (self-reported)	1.8	2.3	7.8	-2.0	-1.8	-0.8	-0.5	-2.8	-0.6	0.0
Medication: Omeprazole (e.g. Zanprol)	1.8	2.1	3.5	1.6	1.4	-1.6	-1.7	-0.1	-1.9	-1.4
Supplements: Calcium	1.8	2.0	4.1	-0.6	0.3	-2.0	-2.0	-1.2	-1.6	-1.2
Respiratory disease	1.7	3.8	8.8	0.2	1.2	-2.2	-2.2	-1.5	-2.1	-3.0
Townsend deprivation index at recruitment	1.7	2.3	6.9	2.6	2.2	0.6	0.5	2.0	0.2	0.4
Age when periods started (menarche)	1.7	4.0	7.1	-0.2	-1.0	-2.7	-2.5	-1.9	-2.2	-2.2
High blood pressure	1.7	4.7	8.8	0.8	0.8	2.3	1.9	2.5	3.0	2.7
Pulse wave peak to peak time	1.7	2.0	3.4	1.3	1.6	-1.1	-1.5	0.6	-1.9	-1.6
Medication: Blood pressure	1.7	3.3	5.7	1.1	1.2	2.0	1.6	2.4	2.4	1.8
Hearing difficulty/problems: Yes	1.6	2.5	4.4	1.0	2.0	1.1	0.8	1.8	1.8	2.1
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	5.2	-1.8	-1.6	-0.5	0.2	-2.3	-1.0	0.4
Length of working week for main job	1.6	1.8	3.5	1.4	1.9	1.4	0.9	1.7	0.8	0.5
Worry too long after embarrassment	1.6	2.6	5.4	-0.3	-0.6	1.9	2.1	1.0	1.9	2.3
Hypertension (Self-reported)	1.6	4.3	8.7	0.6	0.7	2.4	2.0	2.2	3.0	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	5.4	-2.3	-1.8	-1.5	-1.1	-1.9	-2.1	-1.7
Vascular/heart problems diagnosed by doctor	1.6	4.3	7.8	-0.6	-0.4	-2.2	-1.9	-2.4	-2.7	-2.8
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.2	-1.4	-1.5	-1.5	-1.3	-1.4	-0.8	-1.0
Migraine (self-reported)	1.5	1.8	3.9	-0.8	-0.1	-2.0	-1.9	-1.5	-1.2	-1.1
Blood Platelet Count	1.4	16.2	27.0	-0.0	-0.3	5.0	5.2	3.9	4.5	5.2
Financial difficulties in last 2 years	1.4	1.9	3.6	1.7	1.9	-1.6	-1.6	0.5	-1.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	6.1	1.1	1.8	1.4	1.2	2.5	2.0	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.4	-1.9	-1.3	1.3	1.5	-0.4	1.6	-0.2
Financial situation satisfaction	1.4	1.8	4.8	1.6	1.6	-1.1	-1.1	0.1	-2.2	0.1
Medication: Bendroflumethiazide	1.4	2.1	4.0	-0.6	0.4	1.7	1.5	1.8	2.0	1.4
Bipolar Disorder (2018)	1.3	2.0	7.2	-0.2	-0.6	-1.2	-1.3	-1.3	-1.3	-2.7
Allergy or Eczema	1.3	3.5	9.4	-1.5	-1.6	-1.9	-1.6	-3.1	-1.9	-0.9
Sensitivity / hurt feelings	1.3	2.2	3.2	-1.6	-0.9	1.6	1.8	1.4	1.3	1.6
Frequency of depressed mood in last 2 weeks	1.3	1.9	4.1	0.2	0.1	-1.9	-2.0	-0.5	-1.7	-1.5
Time employed in main current job	1.3	1.5	3.0	-0.9	-1.2	1.4	1.7	0.2	1.0	1.5
Medication: Omeprazole	1.3	1.5	3.6	0.9	0.8	-1.3	-1.3	-0.7	-1.9	-1.4
Diabetes diagnosed by doctor	1.3	2.1	4.7	0.2	0.4	1.7	1.9	0.6	1.6	2.2
Heart disease (siblings)	1.3	1.6	2.9	-0.6	-1.1	-1.1	-1.0	-1.7	-1.6	-1.3
Heel T-Score	1.2	9.6	15.8	-2.3	-0.5	4.0	3.9	2.0	3.6	3.6
Supplements: Zinc	1.2	1.3	2.6	0.9	1.6	0.7	0.8	1.5	1.4	0.2
Birth weight of first child	1.2	2.2	3.7	-1.4	-0.9	-1.7	-1.6	-1.9	-1.3	-1.4
Eye problems/disorders: None of the above	1.2	1.4	4.8	2.2	1.9	-0.2	-0.6	0.9	-0.3	0.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.7	-0.4	-0.2	1.6	1.6	1.6	1.3	1.1
Commuting to job workplace: Walk	1.2	1.3	2.3	-0.2	-0.7	1.5	1.3	0.9	1.4	1.3
Osteoporosis (self-reported)	1.2	1.4	2.6	0.9	0.7	-0.9	-0.8	-1.6	-1.6	-1.5
Medication: Aspirin	1.2	1.5	3.0	-0.7	-1.3	1.1	1.5	-0.9	1.1	1.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.2	-1.5	-1.1	1.3	1.5	0.4	0.9	1.0
Medication: Atenolol	1.1	1.3	3.8	0.7	0.5	0.9	1.1	0.7	1.6	1.9
Pain all over the body in last month	1.1	1.1	3.8	0.6	-0.7	-1.4	-1.0	-0.5	-0.5	1.9
Medication: Ramipril	1.1	1.4	3.3	1.7	1.8	-0.4	-1.2	1.1	-0.5	-0.4
Tense / ‘highly strung’	1.1	1.8	4.6	-1.7	-1.4	-0.9	-0.6	-2.1	-1.4	-0.3
Guilty feelings	1.1	1.6	2.7	-0.1	0.2	1.6	1.5	1.6	1.3	1.4
Had menopause	1.0	1.3	2.6	-0.6	-0.4	-1.6	-1.5	-1.1	-1.6	-0.5
Wheeze or whistling in the chest in last year	1.0	1.8	3.5	-0.3	-0.7	-1.7	-1.9	-1.0	-1.8	-1.1
Comparative height size at age 10	1.0	5.4	9.0	-0.2	1.1	2.6	2.6	3.0	3.0	2.2
Back pain experienced in last month	1.0	1.4	4.1	-1.4	-1.1	0.5	0.5	-2.0	0.1	-1.4
Myopia	1.0	1.5	4.2	0.6	1.3	1.1	1.2	1.1	0.6	2.1
Qualifications: CSEs or equivalent	0.9	1.2	1.9	-1.0	-1.1	1.2	1.4	1.2	0.7	0.9
Commuting to job workplace: Car/motor vehicle	0.9	1.1	3.0	-1.4	-1.7	-0.8	-0.4	-1.2	-0.4	0.1
Long-standing illness, disability or infirmity	0.9	1.4	5.9	0.9	0.3	0.5	0.8	-0.0	1.3	2.4
Commuting to job workplace: Public transport	0.9	1.0	2.4	1.2	1.5	0.2	-0.1	1.5	0.2	1.0
Commuting to job workplace: Cycle	0.9	1.1	3.4	-1.8	-0.9	1.1	0.8	-0.0	1.1	0.3
Schizophrenia vs Biploar Disorder	0.8	1.1	4.1	1.0	0.9	-0.4	-0.4	1.1	-0.1	2.0
Ovarian Cancer	0.8	1.0	2.3	-1.5	-0.9	-0.4	-0.3	-1.5	-0.9	-0.9
Coronary Artery Disease (CAD)	0.8	0.9	2.8	1.3	1.7	-0.2	-0.4	1.2	-0.4	0.0
Average weekly fortified wine intake	0.8	0.9	1.7	1.2	0.8	0.4	0.0	1.3	1.2	1.1
Hayfever, allergic rhinitis or eczema	0.8	1.7	6.1	-1.0	-1.5	-0.6	-0.4	-2.5	-1.5	0.2
Diabetes (self-reported)	0.8	1.2	2.8	-0.5	-0.4	1.3	1.5	0.0	1.2	1.7
Alcohol intake versus 10 years previously	0.8	1.1	2.2	-0.5	-1.2	-1.4	-1.1	-0.7	-1.5	-0.2
Breastfed as a baby	0.8	1.0	3.3	0.1	-0.5	-1.2	-0.7	-1.8	-1.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.5	-0.3	-0.4	-1.1	-1.0	-1.6	-1.6	-1.1
Medication: Amlodipine	0.8	1.1	2.0	0.7	0.8	1.2	0.8	0.9	1.4	1.3
Number of children fathered	0.8	0.9	2.7	-1.6	-0.6	0.9	1.3	-0.0	0.7	0.7
Mother’s age at death	0.8	1.0	4.0	-0.1	0.2	1.0	0.9	0.9	2.0	0.8
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.9	1.0	0.3	1.4	1.2	0.4	0.8	1.4
Depression (Nagel 2018)	0.7	1.1	1.6	-0.8	-1.0	-1.0	-0.8	-1.2	-1.2	-1.0
Alzheimer’s Disease (in mother)	0.7	0.9	1.9	0.2	0.8	1.3	1.4	0.8	0.5	0.9
Bipolar Disorder (2011)	0.7	0.7	1.4	-0.0	-1.2	-0.4	0.1	-1.1	-0.6	-1.2
Medication for hormone replacement therapy	0.7	0.7	1.7	0.0	0.6	-1.0	-0.8	0.0	-1.3	-1.3
Multivitamins +/- minerals	0.7	0.9	2.1	0.2	0.0	1.2	1.1	1.5	1.0	0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.2	-0.5	-0.7	-1.1	-0.8	-0.8	-1.1	-1.1
Sitting height	0.7	4.7	9.2	-0.4	0.7	2.3	2.5	3.0	2.3	2.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.6	-1.2	-0.6	-1.3	-1.0	-0.8	-0.7	-0.1
Mouth/teeth dental problems	0.7	1.1	1.7	0.0	0.2	1.3	1.2	0.9	1.3	1.3
Hip circumference	0.7	2.9	5.0	-1.8	-0.6	2.1	2.2	1.1	1.7	1.9
Depression (self-reported)	0.7	0.8	1.8	0.2	0.8	-1.2	-1.2	-0.5	-1.3	-0.5
Medication: Lansoprazole	0.7	0.8	1.7	0.9	1.3	-0.7	-1.0	0.7	-0.9	-0.5
Peak expiratory flow (PEF)	0.7	1.5	3.7	-1.9	-1.8	0.5	0.5	-1.6	-0.0	-0.7
Neck or shoulder pain in last month	0.7	1.0	3.3	-1.2	-0.0	-0.3	-0.6	-1.4	-0.2	-1.8
Smoking status: Previous	0.7	1.0	2.6	-1.4	-1.6	0.6	0.4	0.4	1.1	0.9
Mood swings	0.7	1.3	4.5	-2.1	-1.9	0.5	0.5	-0.7	0.0	0.2
Hearing aid user	0.7	0.8	3.1	-0.6	-0.8	-0.3	0.0	-1.8	-0.2	-1.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	3.5	-1.9	-1.0	0.4	0.9	0.6	0.7	0.7
Pain experienced in last month	0.7	1.2	4.9	1.2	0.8	0.5	0.7	2.2	0.5	0.9
Bipolar Disorder or Schizophrenia	0.6	1.4	4.4	0.2	-0.2	-1.3	-1.5	-0.1	-1.1	-2.1
Breast Cancer	0.6	1.6	3.8	-1.3	-1.9	1.2	1.4	-0.7	0.8	1.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	-0.4	0.3	0.9	0.8	1.4	1.1	0.9
HbA1C	0.6	0.7	1.7	-1.0	-1.1	0.4	0.6	-0.2	0.4	1.3
Lung FVC	0.6	3.1	6.5	-1.3	-1.2	-1.5	-1.4	-1.5	-2.5	-2.4
Neuroticism	0.6	1.3	3.0	-1.4	-1.7	0.8	1.2	-0.3	0.5	1.3
Maternal smoking around birth	0.6	0.8	2.7	-1.6	-1.4	0.5	0.8	-0.3	-0.1	0.2
Heart attack	0.6	0.7	1.2	1.0	0.3	1.1	0.9	0.3	0.7	1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.7	1.9	0.4	0.3	0.3	0.5	-0.1	1.2
Medication: Simvastatin	0.6	0.9	1.3	-1.0	-0.9	1.0	1.2	-0.9	0.9	0.8
Neuroticism score	0.6	1.2	2.4	-1.6	-1.4	1.0	1.2	0.2	0.4	1.3
Falls in the last year	0.6	0.9	1.8	0.2	-0.6	-1.4	-1.1	-1.3	-0.8	-0.5
Hair/balding pattern: Pattern 3	0.6	0.9	3.0	0.1	-0.5	0.7	0.6	1.7	0.3	1.5
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.3	0.8	1.2	-1.2	-1.5	0.1	-1.5	-1.3
Hair/balding pattern: Pattern 4	0.6	1.5	3.2	-0.2	-0.2	-1.6	-1.5	-1.8	-1.5	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.2	-0.1	-1.0	-0.7	-0.8	-0.7	-0.1	-1.5
Health satisfaction	0.6	0.8	2.5	0.1	0.8	0.7	0.5	0.6	1.6	1.2
Medication: Aspirin	0.6	0.8	1.6	-0.4	-0.7	0.9	1.3	-0.9	0.9	1.1
Illnesses of father: Heart disease	0.6	0.8	2.7	-0.1	-0.7	0.6	0.5	0.8	1.6	1.0
Illnesses of siblings: Diabetes	0.6	0.8	2.6	-1.6	-1.5	0.1	0.2	-0.5	0.5	-0.0
Asthma (self-reported)	0.6	1.1	2.6	0.5	0.5	-0.7	-0.6	-1.2	-1.5	-1.6
Number of self-reported non-cancer illnesses	0.6	1.0	3.0	0.1	-0.2	0.9	1.1	-0.1	1.4	1.7
Miserableness	0.6	1.0	2.3	-1.2	-1.1	-1.1	-0.8	-0.7	-1.5	0.0
Cholesterol lowering medication	0.6	0.9	2.2	-1.5	-1.3	0.1	0.4	-1.4	0.0	0.1
Fasting Glucose	0.5	0.6	2.0	0.5	0.2	-0.7	-0.9	-0.6	-1.4	-0.1
Blood Red Count	0.5	4.6	8.0	-0.8	-1.7	-2.8	-2.5	-2.0	-2.6	-1.8
Average weekly spirits intake	0.5	0.7	3.2	0.1	0.7	0.1	0.3	0.6	0.7	1.8
Vitamin and mineral supplements	0.5	0.6	1.0	-0.2	-0.4	-0.9	-0.9	-1.0	-0.7	-0.9
Diabetes (mother)	0.5	0.6	1.9	-1.4	-1.2	-0.0	0.3	-0.5	-0.4	0.6
Fed-up feelings	0.5	0.8	2.0	-0.1	0.2	0.9	1.0	1.4	0.3	1.4
Relative age voice broke	0.5	0.8	2.0	-0.1	0.2	0.9	0.9	1.3	1.4	0.7
Stomach or abdominal pain in last month	0.5	0.6	1.5	0.0	0.4	-0.7	-1.0	-0.6	-1.2	-1.0
High blood pressure (mother)	0.5	0.7	1.8	-0.5	-0.3	0.7	0.5	0.9	1.0	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.0	-1.7	-1.3	-0.3	-0.2	-0.5	-0.5	0.2
Allergy	0.5	1.1	4.0	0.4	0.9	0.7	0.4	2.0	1.5	0.5
Worrier / anxious feelings	0.5	0.9	1.8	-0.8	-1.3	1.2	1.1	0.4	-0.1	0.9
Medication: Cholesterol lowering	0.5	0.9	1.6	-0.8	-0.4	1.1	1.3	-0.3	1.2	0.8
Lung cancer (father)	0.5	0.5	1.7	0.5	1.1	0.2	0.1	1.3	0.6	0.3
Illnesses of mother	0.5	0.6	1.1	1.1	0.3	-0.7	-0.8	-0.7	-0.5	-0.9
Glaucoma (self-reported)	0.5	0.6	1.2	0.8	0.6	1.1	1.1	0.5	0.7	0.6
Medication: Seretide 50 evohaler	0.5	0.6	1.2	-0.9	-1.1	0.9	0.9	-0.3	0.5	-0.3
Pulse rate, automated reading	0.5	1.5	4.0	-0.7	-0.3	-1.1	-0.8	-1.6	-1.1	-2.0
Number of full sisters	0.5	0.6	2.5	-0.5	-0.8	0.1	0.2	0.2	0.7	1.6
Ever had bowel cancer screening	0.5	0.6	1.5	-0.7	-0.4	0.5	1.2	-0.1	0.2	1.2
Wears glasses or contact lenses	0.5	0.6	1.5	1.2	0.7	0.3	0.5	1.0	-0.0	0.9
Ever taken oral contraceptive pill	0.5	0.5	0.8	0.9	-0.2	-0.6	-0.9	-0.8	-0.8	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	1.2	1.3	0.1	0.2	0.5	-0.3	0.7
High cholesterol (Self-reported)	0.5	0.8	3.0	-1.7	-0.9	0.3	0.4	-1.3	-0.0	-0.0
Medication: Lisinopril	0.5	0.7	1.5	1.2	1.1	0.7	0.5	1.0	0.3	0.1
Alcohol drinker status: Never	0.5	0.6	1.8	-0.4	-0.5	-0.7	-0.5	-1.3	-1.0	-0.0
Average weekly beer plus cider intake	0.5	0.7	1.7	0.6	-1.3	-0.3	-0.2	-1.1	-1.0	0.5
Unable to work because of sickness or disability	0.5	0.6	2.6	-0.1	-0.5	0.6	0.7	0.4	0.8	1.6
Alzheimer’s Disease (including proxy)	0.4	0.5	1.3	-0.5	0.2	0.9	1.2	0.4	0.2	1.1
Prostate Cancer	0.4	0.6	1.5	0.9	1.2	-0.7	-0.8	-0.4	-0.8	-0.2
Age at First Birth	0.4	0.6	1.9	-1.4	-1.3	-0.2	-0.1	-0.3	0.8	-0.1
Neuroticism (2016)	0.4	0.5	1.9	0.6	-0.5	0.4	0.9	0.3	-0.4	1.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.8	-0.2	-0.1	-0.8	-0.7	-0.4	-1.3	-0.6
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	-1.1	-0.8	0.1	0.5	-0.2	-0.0	0.9
Systolic blood pressure, automated reading	0.4	1.1	2.8	-0.5	-1.4	0.7	1.0	0.3	1.7	1.2
Severe depression (siblings)	0.4	0.5	1.7	-1.0	-1.3	0.5	-0.3	-0.7	0.1	0.0
Leg fat-free mass (left)	0.4	1.9	3.3	-1.4	-0.2	1.5	1.6	1.0	1.8	1.3
Serious illness, injury or assault to yourself	0.4	0.5	1.0	0.4	0.4	-0.7	-0.7	-1.0	-0.8	-0.7
Trunk fat mass	0.4	1.5	4.8	-2.2	-1.1	0.7	1.2	0.3	0.8	1.4
Weight	0.4	2.1	3.1	-1.8	-0.4	1.4	1.6	1.2	1.6	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	2.0	-0.0	-0.5	-0.3	-0.3	-1.4	-0.0	-0.8
Asthma	0.4	0.9	2.0	0.3	0.5	-0.5	-0.4	-1.1	-1.4	-1.4
Standing height	0.4	4.0	11.6	-0.3	1.5	1.8	1.8	3.4	2.1	1.7
Pulse wave reflection index	0.4	0.4	1.7	0.1	-0.7	0.1	0.8	-1.3	0.3	0.4
Headache pain in last month	0.4	0.7	1.9	-0.3	0.6	-1.3	-1.4	-0.4	-0.8	-0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.8	0.3	0.1	-1.0	-1.0	-0.3	-1.4	-0.7
Gout (self-reported)	0.4	0.5	1.3	0.4	0.5	0.9	0.8	1.1	0.6	0.4
Birth weight	0.4	0.8	1.4	-1.2	-1.0	-1.1	-0.9	-0.8	0.4	0.5
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	-1.1	0.0	0.4	0.7	-0.7	-0.2	-0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	2.9	0.6	0.6	0.9	0.6	1.7	0.7	-0.2
Medication: Allopurinol	0.4	0.5	1.9	0.7	0.7	0.6	0.4	1.4	0.1	-0.5
Suffer from ‘nerves’	0.4	0.6	1.5	-0.2	-0.5	0.6	1.0	0.2	1.1	1.2
Leg fat-free mass (right)	0.4	2.2	3.6	-1.6	-0.3	1.7	1.8	1.0	1.9	1.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.3	0.2	0.4	-0.8	-0.6	-0.5	-0.1	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.1	1.0	0.8	0.1	-0.0	0.2	0.4	-1.0
Friendships satisfaction	0.4	0.5	1.6	1.2	0.7	0.2	0.1	-1.1	-0.3	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.5	0.0	-0.4	-0.6	-0.6	-1.1	-1.2
Leg predicted mass (right)	0.4	2.2	3.8	-1.6	-0.3	1.7	1.7	1.1	1.9	1.4
Leg fat percentage (left)	0.4	1.4	4.8	-2.2	-1.8	-0.3	0.1	-0.9	-0.4	0.8
Diastolic blood pressure, automated reading	0.4	1.2	3.2	-0.3	-1.4	0.9	1.1	0.6	1.0	1.8
Depressed Affect (Nagel 2018)	0.3	0.6	1.3	-1.1	-0.8	-0.6	-0.3	-1.0	-0.9	0.2
Primary Biliary Cirrhosis	0.3	0.5	1.7	0.4	-0.0	-0.3	-0.2	-0.6	-0.9	-1.3
Schizophrenia (2014)	0.3	0.6	1.5	-0.1	-0.2	-1.2	-1.2	0.4	-0.8	-0.6
Ulcerative Colitis	0.3	0.5	0.9	0.6	-0.3	-0.7	-0.6	-0.9	-0.9	-0.7
Blood White Count	0.3	2.4	5.3	0.4	0.6	-1.8	-1.6	-1.0	-2.0	-2.3
BMI	0.3	2.0	3.6	-1.9	-1.0	1.1	1.5	0.0	1.6	1.9
Systolic Blood Pressure	0.3	1.3	3.7	0.6	-0.7	1.2	1.0	1.0	1.9	1.0
Relative age of first facial hair	0.3	0.6	1.6	0.5	1.1	-0.7	-0.7	1.2	0.3	-0.5
Angina	0.3	0.4	0.9	0.6	0.4	0.7	0.7	-0.5	0.6	1.0
Medication: Metformin	0.3	0.5	2.8	0.3	0.1	0.4	0.4	0.2	0.3	1.7
Pack years adult smoking proportion	0.3	0.5	1.7	1.3	1.0	-0.1	-0.2	0.8	-0.3	-0.1
Trunk fat percentage	0.3	1.3	3.7	-1.9	-0.9	0.7	1.1	0.3	0.7	1.6
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	0.2	0.8	0.5	0.6	0.9	0.7	0.6
Leg predicted mass (left)	0.3	1.8	3.1	-1.4	-0.2	1.5	1.5	1.0	1.8	1.3
Waist circumference	0.3	1.2	2.0	-1.3	-0.5	1.1	1.3	0.6	1.2	1.4
Number of incorrect matches in round	0.3	0.5	2.2	1.5	0.4	-0.6	-0.6	0.1	-0.3	0.1
Past tobacco smoking	0.3	0.5	1.7	1.2	1.3	-0.1	0.1	0.1	-0.2	-0.4
Alcohol usually taken with meals	0.3	0.6	1.0	0.2	0.8	1.0	0.8	0.9	0.8	0.4
Nervous feelings	0.3	0.5	1.7	-0.3	-1.3	-0.6	-0.1	-0.2	-0.3	0.9
Father’s age at death	0.3	0.4	1.2	-0.1	-0.4	-1.1	-0.8	-0.5	-0.7	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.9	-0.8	-0.6	0.8	1.0	-0.5	0.5	0.7
Prospective memory result	0.3	0.3	0.7	-0.2	-0.4	-0.8	-0.5	-0.8	-0.6	-0.1
Loud music exposure frequency	0.3	0.3	1.4	-0.4	0.2	-0.5	-0.7	-0.1	-0.2	-1.2
Body fat percentage	0.3	1.1	3.9	-2.0	-1.1	0.3	0.7	-0.2	0.2	1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	0.9	0.8	0.4	0.4	0.2	-0.6	0.1
Angina (self-reported)	0.3	0.3	0.6	0.5	0.3	0.6	0.6	-0.7	0.5	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.9	0.1	-0.1	0.9	0.6	-0.1	1.0	0.5
Whole body fat mass	0.3	1.2	4.5	-2.1	-1.0	0.5	0.8	0.0	0.5	1.4
Leg fat mass (right)	0.3	1.0	4.3	-2.1	-1.2	0.2	0.4	-0.4	0.1	0.9
Chest pain or discomfort	0.3	0.4	0.9	-0.2	0.5	-0.8	-0.9	-0.9	0.2	0.1
Had major operations	0.3	0.3	0.7	-0.2	-0.4	-0.8	-0.5	-0.8	-0.7	-0.5
Leg pain on walking	0.3	0.4	1.0	0.1	-0.3	-0.9	-1.0	-0.7	-0.2	-0.3
Knee pain experienced in last month	0.3	0.5	1.3	-0.5	-1.1	-0.6	-0.9	-0.8	0.1	0.2
Arm fat percentage (left)	0.3	1.0	3.8	-1.9	-1.3	0.2	0.6	-0.5	0.2	0.9
Medication for cholesterol	0.3	0.5	0.9	0.6	-0.1	-1.0	-0.9	-0.6	-0.9	-0.6
Mineral and other dietary supplements	0.3	0.4	1.9	1.4	0.8	0.2	-0.1	0.3	-0.1	-0.1
Average weekly champagne plus white wine intake	0.3	0.4	1.7	-0.8	-0.1	-0.6	-1.3	0.4	0.1	-0.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	0.9	0.3	0.8	0.8	0.4	0.2	-0.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.9	-0.2	0.6	0.3	-0.6	0.9	0.8
Irritability	0.3	0.6	1.8	-1.1	-0.6	0.2	-0.2	-1.3	0.0	-0.6
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.6	-0.4	-1.3	-0.4	-0.1	-0.5	-0.6	-0.1
Fractured/broken bones in last 5 years	0.3	0.3	1.1	0.5	0.6	-0.1	-0.5	0.4	1.0	0.6
Age started oral contraceptive pill	0.3	0.3	1.0	1.0	0.7	0.3	0.4	0.2	0.4	0.5
Basal cell carcinoma (self-reported)	0.3	0.3	1.8	-1.3	-0.0	-0.4	-0.5	-0.4	-0.2	-0.3
Leg fat mass (left)	0.3	1.1	5.0	-2.2	-1.3	0.1	0.3	-0.5	0.1	0.8
Neuroticism (Nagel 2018)	0.2	0.5	1.1	-1.1	-0.9	0.3	0.5	-0.3	-0.0	0.9
Schizophrenia (2018)	0.2	0.4	0.8	0.4	0.3	-0.7	-0.9	0.9	-0.3	-0.5
Worry (Nagel 2018)	0.2	0.5	1.1	-0.8	-0.7	0.8	1.1	-0.3	0.3	0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.8	-0.0	-0.2	-0.4	0.1	-0.9	-0.8	0.1
Major Depression (MDD)	0.2	0.3	0.9	-0.9	-0.6	0.3	0.6	-0.2	0.5	0.2
Crohns Disease (2012)	0.2	0.4	0.7	0.7	0.1	0.4	0.6	0.7	0.8	0.9
HDL Cholesterol	0.2	0.3	1.6	-0.2	-0.1	0.3	0.5	0.1	0.1	1.3
Lupus	0.2	0.3	0.6	-0.4	-0.8	0.6	0.8	0.2	0.4	-0.5
Triglycerides	0.2	0.3	0.5	0.2	0.5	-0.3	-0.7	0.7	-0.4	-0.6
Height	0.2	2.9	6.2	-1.0	0.0	2.2	2.5	1.6	1.5	1.9
Waist Hip Ratio (WHR)	0.2	1.1	3.3	1.8	1.1	-1.0	-1.1	0.7	-0.4	-0.2
Smoking Status	0.2	0.4	0.8	-0.9	-0.9	-0.3	-0.5	-0.5	-0.6	0.4
Hypothyroidism (self reported)	0.2	0.5	1.4	0.9	1.2	-0.3	-0.5	0.5	0.5	0.3
Lung FEV1/FVC ratio	0.2	0.8	1.8	-1.0	-1.4	0.7	1.0	-0.4	0.3	1.0
Chronotype (morning person)	0.2	0.4	1.3	0.2	-0.2	-0.6	-0.7	0.2	-1.2	-0.7
Medication: Co-codamol	0.2	0.2	0.7	0.3	-0.2	-0.6	-0.5	-0.5	-0.8	-0.3
Impedance of leg (right)	0.2	1.2	2.7	1.1	0.6	-1.3	-1.4	0.1	-1.7	-0.7
Current tobacco smoking	0.2	0.3	0.8	0.6	0.8	-0.3	-0.4	-0.0	-0.9	-0.2
Taking other prescription medications	0.2	0.2	0.8	-0.4	-0.0	-0.0	0.2	-0.7	0.3	0.9
Body mass index (BMI)	0.2	0.9	2.9	-1.7	-1.0	0.5	0.7	-0.2	0.7	1.0
Impedance of leg (left)	0.2	0.9	2.4	0.5	0.2	-1.2	-1.2	0.1	-1.6	-0.6
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.3	-0.1	0.1	0.5	-0.8	0.5	-0.6
Impedance of arm (right)	0.2	0.9	1.8	0.9	1.1	0.8	0.9	1.3	0.8	0.9
Arm fat percentage (right)	0.2	0.9	3.1	-1.8	-1.2	0.2	0.5	-0.3	0.2	1.0
Number of live births	0.2	0.3	0.6	0.4	0.8	-0.3	-0.6	-0.6	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	3.1	-1.8	-0.9	0.3	0.2	-0.2	-0.2	-0.9
Happiness	0.2	0.3	0.9	0.7	0.5	0.1	-0.2	-0.1	-0.3	0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	-0.7	-0.1	0.3	0.8	-0.4	0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.7	-1.6	-1.2	0.2	0.3	-0.5	-0.6	-0.4
Arm fat mass (right)	0.2	1.0	3.5	-1.9	-1.0	0.4	0.7	0.1	0.6	1.1
Exposure to tobacco smoke at home	0.2	0.3	0.6	0.5	-0.0	0.8	0.7	0.2	0.1	0.6
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	0.4	0.3	0.4	0.2	0.0	0.9	0.8
Blood clot in the leg (DVT)	0.2	0.2	0.5	0.6	-0.0	0.7	0.7	0.1	0.2	0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	0.5	0.9	-0.8	-1.0	-0.1	0.3	-0.2
Leg fat percentage (right)	0.2	0.8	2.6	-1.6	-1.4	-0.3	-0.0	-0.7	-0.4	0.8
Exposure to tobacco smoke outside home	0.2	0.3	1.0	-0.6	-1.0	-0.0	0.0	-0.8	0.2	0.2
Age at first live birth	0.2	0.3	0.9	-0.5	-1.0	0.1	-0.1	-0.0	0.9	0.3
Medication: Blood pressure	0.2	0.4	0.9	0.3	0.2	0.9	0.7	0.6	0.9	0.5
Mean time to correctly identify matches	0.2	0.5	1.1	0.2	-0.8	-1.0	-0.9	-0.6	-0.7	0.1
Alcohol intake frequency.	0.2	0.4	0.7	-0.4	-0.7	-0.8	-0.7	-0.3	-0.8	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	0.0	-0.3	0.1	0.0	0.6	0.5	0.9
Whole body fat-free mass	0.2	1.0	2.0	-1.4	-0.1	1.0	0.9	0.9	1.3	0.9
Qualifications: nursing, teaching	0.2	0.3	1.1	0.0	1.1	0.6	0.5	-0.0	-0.1	-0.5
Whole body water mass	0.2	1.0	1.8	-1.3	-0.0	1.0	0.9	1.0	1.3	0.9
Arm fat mass (left)	0.2	0.9	3.6	-1.9	-1.1	0.2	0.6	-0.0	0.4	1.0
Illnesses of father: High blood pressure	0.2	0.2	0.5	0.4	0.4	-0.7	-0.4	-0.7	0.1	0.3
Basal metabolic rate	0.2	1.2	2.1	-1.4	-0.2	1.1	1.0	1.0	1.5	1.1
Pack years of smoking	0.2	0.3	1.1	1.0	0.7	-0.1	-0.1	0.7	-0.4	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.8	0.7	-0.3	-0.4	-0.1	-0.5	-0.9
Crohns Disease (2017)	0.1	0.2	0.5	0.2	0.3	-0.5	-0.0	-0.5	-0.7	0.3
Ulcerative Colitis (UC)	0.1	0.2	0.6	0.4	-0.2	0.3	0.4	0.3	0.3	0.8
Reaction Time	0.1	0.1	0.2	0.4	-0.2	-0.4	-0.3	0.4	0.2	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.6	0.4	0.6	0.5	0.3	-0.0	0.1
LDL Cholesterol	0.1	0.2	0.5	-0.6	0.3	0.1	-0.2	0.7	0.7	0.2
Rheumatoid Arthritis	0.1	0.1	0.2	0.4	-0.1	-0.4	-0.4	-0.1	0.0	-0.2
Blood Eosinophil Count	0.1	1.0	2.6	-0.6	-0.1	-1.5	-1.2	-0.5	-1.6	0.3
Hand grip strength (left)	0.1	0.2	0.5	0.3	0.6	-0.1	-0.6	0.5	-0.1	-0.7
Number of treatments/medications taken	0.1	0.1	0.2	-0.3	0.5	0.3	0.3	0.1	0.4	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	-0.1	-0.0	-0.0	-0.1	-0.4	0.6	0.4
Hand grip strength (right)	0.1	0.4	1.0	0.6	1.0	0.1	-0.7	0.6	0.4	-0.6
Supplements: Glucosamine	0.1	0.1	0.3	-0.1	-0.1	-0.3	0.1	-0.6	-0.3	-0.0
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.7	-0.2	-0.3	-0.5	-0.3	0.7	-0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.1	0.5	0.2	-0.0	0.0	-0.4	-0.5
Had other major operations	0.1	0.1	0.5	-0.2	0.2	-0.3	-0.4	-0.3	-0.0	-0.7
Forced vital capacity (FVC)	0.1	0.5	2.1	-1.5	-0.4	0.2	0.1	0.3	-0.2	-1.0
Qualifications: None of the above	0.1	0.2	1.1	0.4	-0.1	-0.3	-0.4	0.0	-0.1	-1.1
Fluid intelligence score	0.1	0.3	1.1	-1.1	0.6	0.5	0.4	0.3	0.0	-0.1
Illnesses of siblings	0.1	0.2	0.4	0.1	-0.1	-0.5	-0.6	-0.6	-0.6	-0.2
Trunk fat-free mass	0.1	0.9	1.6	-1.1	0.2	0.8	0.7	1.1	1.3	0.8
Impedance of arm (left)	0.1	0.5	1.4	0.9	1.0	0.3	0.5	1.2	0.2	0.6
Trunk predicted mass	0.1	0.7	1.3	-1.1	0.1	0.6	0.5	1.0	1.1	0.7
Medication: Paracetamol	0.1	0.2	0.8	-0.3	-0.2	0.5	0.4	0.0	-0.1	0.9
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	-0.2	-0.1	-0.3	0.0	-0.3	-0.3	-0.3
High blood pressure (siblings)	0.1	0.2	0.4	-0.3	0.5	0.3	0.1	0.7	0.7	0.4
Forced vital capacity (FVC), Best measure	0.1	0.5	1.9	-1.4	-1.0	0.1	0.3	-0.3	-0.6	-0.6
Arm fat-free mass (right)	0.1	0.7	3.8	-1.9	-0.8	0.3	0.3	0.2	0.5	0.4
Number of full brothers	0.1	0.1	0.4	-0.4	-0.6	0.3	0.5	-0.1	-0.0	0.2
Qualifications: College or University degree	0.1	0.3	1.5	0.1	1.2	0.4	0.3	-0.5	-0.1	0.4
Heart disease (mother)	0.1	0.2	0.4	-0.3	-0.5	-0.0	-0.2	-0.0	0.6	0.6
Arm predicted mass (right)	0.1	0.5	2.9	-1.7	-0.5	0.3	0.3	0.4	0.4	0.3
Overall health rating	0.1	0.3	0.5	-0.6	-0.1	0.5	0.7	-0.6	0.5	0.7
Age at last live birth	0.1	0.1	0.5	0.7	0.1	0.3	0.2	-0.0	0.5	0.4
Family relationship satisfaction	0.1	0.2	0.4	-0.1	-0.1	0.5	0.4	-0.6	0.4	-0.3
Smoking status: Current	0.1	0.2	0.8	0.2	0.4	-0.3	-0.3	-0.3	-0.9	-0.3
Medication: Paracetamol	0.1	0.2	0.8	0.4	0.2	0.5	0.4	0.2	0.3	0.9
Medication: Atorvastatin	0.1	0.1	0.2	0.1	-0.1	-0.2	-0.3	-0.5	-0.4	-0.4
Arm fat-free mass (left)	0.1	0.5	2.2	-1.5	-0.3	0.3	0.3	0.5	0.6	0.5
Number of operations (self-reported)	0.1	0.2	0.4	0.2	0.1	-0.6	-0.3	-0.7	-0.6	-0.4
Ever depressed for a whole week	0.1	0.1	0.3	-0.2	0.5	-0.3	-0.1	0.4	-0.0	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	0.7	-0.1	0.6	0.6	-0.0	0.3	0.2
Alcohol drinker status: Previous	0.1	0.1	0.4	0.3	-0.1	0.1	-0.2	0.6	-0.0	0.4
Impedance of whole body	0.1	0.4	0.9	0.8	0.8	-0.3	-0.2	0.9	-0.5	0.1
Arm predicted mass (left)	0.1	0.7	2.4	-1.6	-0.4	0.5	0.5	0.6	0.9	0.7
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	0.1	0.1	-0.2	0.2	-0.1	-0.3	0.5
Hair Pigment	0.0	0.5	1.6	-0.8	-0.6	0.2	0.4	-1.3	-0.6	-0.5
Tanning	0.0	0.2	0.4	0.2	-0.1	-0.5	-0.6	0.3	-0.3	-0.4
Pulse rate	0.0	0.1	0.2	0.1	0.1	0.0	-0.3	-0.1	0.5	0.4
Noisy workplace	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.1	0.1	0.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.3	-0.5	-0.1	0.2	-0.2	-0.1	-0.2	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	0.3	0.1	0.2	0.1	0.2	0.2	-0.2
Ever smoked	0.0	0.1	0.1	-0.4	-0.1	0.4	0.0	0.3	0.1	0.2

Hub : Genes

CRHR2

Models

Trait associations