Hub : Genes

CROCCP3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0960	0.0310	2.3e-06	0.027	0.056	0.043	0.053	0.039	2.7e-04	2.3e-07	5.1e-06	5.0e-07	1.4e-05
2	GTEx	Skin Sun Exposed Lower leg	0.1110	0.0420	4.2e-04	0.112	NA	0.079	NA	0.095	1.6e-09	NA	4.1e-07	NA	2.8e-08
3	GTEx	Testis	0.0650	0.0330	9.2e-03	0.029	NA	0.003	NA	0.017	2.0e-02	NA	2.2e-01	NA	5.9e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.0774	0.0283	3.3e-04	0.010	0.020	0.001	0.020	0.002	1.8e-02	1.0e-03	2.5e-01	1.1e-03	1.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.4	0.8	-0.9	-0.4	-0.9	-0.3
Bipolar Disorder or Schizophrenia	0.9	2.2	4.7	-2.2	1.2	-1.7	0.2
Depressed Affect (Nagel 2018)	0.5	1.0	2.0	-1.4	1.4	-0.3	0.5
Depression (Nagel 2018)	1.1	1.6	2.7	-1.6	1.6	1.0	-0.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.5	-1.9	-1.4	-1.1	0.1
Neuroticism (Nagel 2018)	0.3	0.7	2.0	-1.4	-0.3	-0.9	-0.3
Schizophrenia (2018)	1.2	2.5	4.3	-2.1	1.8	-1.5	0.5
Schizophrenia vs Biploar Disorder	1.2	1.5	2.9	0.9	1.7	1.3	0.9
Worry (Nagel 2018)	0.4	0.9	1.4	-1.1	-0.9	-0.5	-1.2
Alzheimer’s Disease (in mother)	0.8	0.9	2.0	-0.9	1.4	-0.8	-0.4
Alzheimer’s Disease (in father)	2.3	2.5	6.4	1.7	0.7	2.5	0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	2.7	-0.7	1.6	0.0	-0.5
Crohns Disease (2017)	0.7	1.6	2.6	1.6	0.5	1.3	-1.4
Irritable Bowel Disease (IBD)	0.5	1.1	1.4	1.1	1.0	1.0	-1.2
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.5	0.7	0.2	0.0
Major Depression (MDD)	0.3	0.3	0.8	0.9	-0.5	-0.1	-0.5
Reaction Time	1.0	2.0	3.4	1.8	0.2	1.4	1.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.6	-1.3	-0.9	-1.1	0.5
Breast Cancer	0.5	1.3	2.6	-1.1	0.6	-0.9	1.6
Ovarian Cancer	0.3	0.4	0.6	0.8	-0.7	0.6	-0.3
Prostate Cancer	0.7	1.0	2.6	-0.1	-0.5	1.6	-1.0
Age at First Birth	0.9	1.3	2.0	1.2	0.0	1.4	-1.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	1.7	0.2	0.9	0.9	-1.3
Coronary Artery Disease (CAD)	0.6	0.7	2.0	-1.4	-0.1	-0.9	0.2
Crohns Disease (2012)	1.0	1.6	4.0	2.0	-0.8	1.0	-0.9
Mean Putamen Volume	1.3	1.4	3.2	-1.8	-0.0	-0.9	-1.3
Fasting Glucose	0.8	1.0	3.3	-0.7	1.8	-0.3	0.4
HbA1C	0.8	0.9	1.3	0.6	1.0	1.0	1.2
HDL Cholesterol	0.4	0.7	2.5	-1.6	0.2	-0.6	0.2
LDL Cholesterol	1.4	2.3	4.5	-1.0	-0.2	-1.9	2.1
Lupus	0.3	0.4	0.7	0.1	0.8	0.8	-0.5
Neuroticism (2016)	0.3	0.5	0.8	0.6	0.2	0.9	0.7
Primary Biliary Cirrhosis	1.1	1.6	5.2	-0.4	-0.7	-0.7	-2.3
Rheumatoid Arthritis	0.9	1.2	3.2	-0.4	-1.1	-1.8	-0.1
Schizophrenia (2014)	0.5	1.1	2.8	-1.0	1.7	-0.6	0.5
Triglycerides	1.2	2.0	3.8	-0.3	-1.3	-2.0	1.5
Type 2 Diabetes (T2D) (2012)	2.6	3.0	7.4	0.6	-2.7	-1.6	-1.3
Ulcerative Colitis	0.1	0.1	0.4	-0.2	0.6	0.0	0.1
Blood Eosinophil Count	0.2	1.3	4.2	-0.2	0.3	1.0	-2.0
Blood Platelet Count	0.2	1.8	3.0	0.7	1.5	1.3	-1.7
Blood Red Count	0.2	2.4	5.6	-1.5	-0.9	-2.4	1.0
Blood White Count	0.1	0.7	2.4	-0.3	0.5	-0.4	1.6
Heel T-Score	1.6	12.6	18.0	4.2	2.1	3.3	-4.1
BMI	0.8	4.6	10.2	-3.2	1.1	-2.3	-1.2
Height	0.8	16.0	35.5	6.0	-3.2	1.0	-4.2
Waist Hip Ratio (WHR)	0.5	2.2	3.3	-1.2	-1.8	-1.5	-1.4
Systolic Blood Pressure	0.9	4.4	12.1	-1.5	-0.7	-1.7	3.5
Smoking Status	0.6	1.5	2.6	-1.2	-1.6	-1.3	0.6
Allergy or Eczema	0.7	1.9	4.5	-2.1	-0.8	-0.7	-1.4
Cardiovascular Disease	1.9	6.4	10.0	-3.2	-1.2	-2.9	2.4
Hypothyroidism (self reported)	0.3	0.6	2.2	-1.5	-0.0	-0.3	0.5
Respiratory disease	0.6	1.2	1.6	-1.0	-1.3	-1.0	-1.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.7	-0.1	0.5	-0.2
Lung FEV1/FVC ratio	3.1	15.7	32.8	3.1	3.0	5.7	3.4
Lung FVC	1.3	6.4	17.9	-2.3	-1.4	-4.2	0.5
Neuroticism	0.2	0.5	1.4	-1.2	0.3	-0.6	-0.1
Chronotype (morning person)	1.7	4.0	7.9	2.4	0.1	2.8	1.5
Hair Pigment	0.1	3.8	12.0	1.7	0.1	0.5	-3.5
Tanning	0.2	2.7	5.8	1.8	1.2	2.4	0.7
Hand grip strength (left)	0.4	1.0	2.1	1.1	-0.1	0.7	-1.4
Number of treatments/medications taken	1.0	1.9	4.7	-2.2	0.8	-1.2	0.8
Average weekly spirits intake	0.7	0.8	2.6	-0.1	-1.6	-0.4	0.8
Sensitivity / hurt feelings	0.7	1.2	1.8	1.4	-1.1	0.5	1.3
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.7	-0.3	1.9	1.2	0.6
Hearing difficulty/problems: Yes	1.5	2.3	4.8	-1.1	-1.7	-2.2	-0.6
Relative age of first facial hair	1.2	2.5	5.8	2.0	-0.2	0.7	2.4
Other serious medical condition/disability diagnosed by doctor	2.5	3.3	6.0	-2.4	1.1	-2.4	0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.3	-0.4	-1.1	0.8
Ever had hysterectomy (womb removed)	1.0	1.2	3.3	-0.9	1.8	-0.7	0.2
Systolic blood pressure, automated reading	1.1	3.3	11.0	-1.1	-0.9	-0.2	3.3
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	3.2	0.6	-0.1	0.4	-1.8
Angina	2.0	2.7	10.0	-0.4	0.6	0.0	3.2
Medication for hormone replacement therapy	0.4	0.4	0.6	-0.4	0.5	-0.8	0.8
Vitamin and mineral supplements	2.5	3.3	5.7	-2.0	-1.8	-2.4	0.7
Supplements: Zinc	1.2	1.3	2.7	0.4	-1.6	0.2	-1.6
Medication: Co-codamol	1.5	1.7	4.0	-1.4	2.0	0.4	1.0
Medication: Metformin	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.1
Diabetes (father)	1.5	1.9	3.5	-1.9	0.2	-0.8	-1.9
Diabetes (mother)	0.1	0.1	0.3	0.3	0.2	-0.6	0.1
Severe depression (siblings)	1.0	1.2	2.4	1.5	0.0	1.5	0.3
Pack years adult smoking proportion	2.7	4.1	9.0	-3.0	1.1	-2.5	-0.0
Impedance of leg (right)	0.4	1.9	6.5	0.4	-2.5	-1.1	-0.2
Leg fat-free mass (left)	0.6	3.3	9.7	1.0	1.6	0.4	-3.1
Trunk fat percentage	0.7	2.7	9.8	0.0	-0.3	-0.8	-3.1
Hand grip strength (right)	0.4	1.2	3.7	0.3	0.8	0.4	-1.9
Townsend deprivation index at recruitment	0.7	1.0	1.4	1.1	1.2	0.4	1.0
Current tobacco smoking	0.4	0.7	1.1	-0.5	-0.8	-1.1	0.8
Average weekly fortified wine intake	0.2	0.3	0.6	0.8	0.4	0.4	-0.3
Maternal smoking around birth	0.2	0.2	0.7	-0.1	-0.4	0.9	0.3
Fed-up feelings	0.8	1.4	4.0	1.0	0.7	0.3	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	4.1	-0.4	2.0	2.0	-0.5
Relative age voice broke	1.0	1.5	2.8	1.7	-0.2	1.7	-0.8
Taking other prescription medications	1.0	1.5	4.5	-1.2	0.2	-0.4	2.1
Age when periods started (menarche)	0.8	2.0	5.8	-0.5	-2.4	-1.1	0.9
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.9	1.7	-0.6	0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	7.0	2.1	2.2	1.5	-2.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	0.1	-1.1	-0.1	0.8
Qualifications: CSEs or equivalent	1.1	1.5	5.1	0.8	2.3	-0.3	-0.4
Serious illness, injury or assault to yourself	0.3	0.3	0.9	-0.9	-0.1	-0.6	-0.3
High blood pressure	1.5	4.1	9.1	-1.4	-1.3	-1.9	3.0
Hayfever, allergic rhinitis or eczema	1.0	2.1	3.9	-1.7	-0.9	-0.7	-2.0
Multivitamins +/- minerals	1.9	2.4	3.7	1.4	1.6	1.9	-1.2
Stomach or abdominal pain in last month	0.4	0.4	0.5	-0.6	-0.7	-0.7	0.6
Supplements: Glucosamine	1.2	1.5	3.4	1.6	0.5	1.9	-0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.6	-0.3	-0.3	0.4
Medication: Atenolol	0.8	1.0	2.0	1.2	-0.2	-0.6	1.4
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.5	-0.5	-0.2	0.5
Sitting height	0.3	1.8	4.1	2.0	0.8	0.1	-1.5
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	-0.8	0.1	-1.1	0.7
High blood pressure (mother)	0.9	1.3	1.7	-1.2	-0.6	-1.2	1.3
Body mass index (BMI)	0.7	2.8	4.7	-2.2	1.6	-1.4	-1.5
Impedance of leg (left)	0.5	2.3	8.0	0.6	-2.8	-0.9	-0.3
Leg predicted mass (left)	0.6	3.4	9.8	1.1	1.5	0.4	-3.1
Trunk fat mass	0.7	2.9	10.9	0.3	0.3	-0.6	-3.3
Waist circumference	1.1	4.1	9.4	-1.8	0.3	-2.0	-3.1
Number of incorrect matches in round	1.0	1.6	2.8	0.3	-1.7	-1.1	1.5
Past tobacco smoking	0.8	1.4	2.5	-1.0	1.6	-1.4	0.4
Alcohol usually taken with meals	1.1	1.8	4.4	0.6	1.4	0.5	-2.1
Nervous feelings	0.7	1.3	2.7	-0.3	-1.6	-1.1	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.9	0.6	1.4	0.3	0.8
Hearing difficulty/problems with background noise	0.5	0.9	2.3	-0.5	-0.9	-1.5	0.3
Hair/balding pattern: Pattern 2	0.6	0.8	1.9	-0.4	0.5	-0.8	-1.4
Had menopause	1.0	1.2	4.9	0.0	-0.2	0.0	2.2
Had other major operations	0.5	0.6	2.0	0.3	-0.3	-1.4	0.4
Forced vital capacity (FVC)	0.7	2.8	5.8	0.7	-2.1	-2.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	2.9	6.6	18.2	1.7	1.9	1.3	-4.3
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	6.3	-1.1	0.8	0.4	-2.5
Qualifications: None of the above	0.8	1.6	5.2	-2.3	-0.0	-0.8	0.8
Financial difficulties in last 2 years	2.1	2.8	9.2	-1.3	3.0	-0.3	-0.5
Mouth/teeth dental problems	1.2	1.9	6.6	0.1	2.6	0.7	-0.6
Heart attack	0.4	0.6	2.0	0.3	-0.1	0.4	1.4
Allergy	0.6	1.3	2.4	1.1	1.2	0.5	1.6
Pain all over the body in last month	0.5	0.5	1.3	-0.2	0.0	-1.1	0.8
Diabetes (self-reported)	0.7	1.1	4.1	0.4	-2.0	-0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-1.1	0.6	0.1	-0.4
Medication: Ramipril	0.9	1.1	2.5	-0.1	-0.8	-1.2	1.6
Medication: Simvastatin	1.5	2.2	3.5	-1.9	-1.3	-1.7	0.8
Fluid intelligence score	0.6	1.3	2.6	-0.2	-1.6	-1.0	1.3
Illnesses of siblings	1.9	2.6	3.9	0.2	1.9	2.0	-1.7
Neuroticism score	0.1	0.3	0.4	-0.7	0.3	-0.4	0.6
Weight	0.7	3.3	11.6	-0.2	0.9	-0.9	-3.4
Impedance of arm (right)	0.9	4.3	7.7	2.7	-2.8	1.2	-1.0
Arm fat percentage (right)	0.4	1.7	5.1	-0.9	0.3	-0.9	-2.3
Trunk fat-free mass	0.4	2.2	5.6	0.8	1.6	0.1	-2.4
Hip circumference	0.9	4.1	11.5	-0.9	1.1	-1.6	-3.4
Time employed in main current job	0.3	0.4	1.2	-0.2	0.3	-0.5	-1.1
Alcohol intake versus 10 years previously	0.7	1.1	2.9	0.2	-1.1	-0.3	1.7
Father’s age at death	0.2	0.2	0.6	0.8	0.1	0.3	-0.5
Worrier / anxious feelings	0.1	0.1	0.2	-0.4	0.2	0.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.3	-1.0	1.8	-0.3	0.4
Falls in the last year	0.8	1.1	1.5	-1.2	1.2	-1.0	0.5
Hair/balding pattern: Pattern 3	0.8	1.3	2.5	1.5	0.2	1.6	0.5
Number of live births	0.2	0.3	0.9	-1.0	-0.1	0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.2	1.1	-0.7	-0.7	-0.2
Pulse rate	0.8	1.4	4.4	-0.7	0.5	-0.6	2.1
Happiness	0.4	0.4	1.1	-0.5	1.0	-0.5	0.4
Noisy workplace	0.2	0.2	0.4	-0.4	0.1	-0.6	0.5
Qualifications: A levels/AS levels or equivalent	1.1	2.5	7.7	-0.9	1.1	-0.5	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.5	0.6	-0.0	-0.5
Mouth/teeth dental problems: Dentures	0.8	1.4	2.5	0.8	-0.5	1.4	1.6
Asthma	0.8	1.5	2.9	-1.7	-0.9	-1.4	-0.6
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	7.2	-0.6	1.9	0.3	-2.7
Medication: Cholesterol lowering	0.4	0.6	1.8	-0.3	-0.6	0.1	1.4
Depression (self-reported)	0.3	0.3	0.6	0.8	0.0	0.6	0.6
Medication: Lansoprazole	1.3	1.4	3.8	-1.2	0.6	-1.9	0.3
Prospective memory result	1.9	2.4	5.3	2.3	0.6	1.9	-0.5
Lung cancer (father)	0.4	0.5	1.1	1.0	0.2	1.0	-0.1
Illnesses of mother	0.9	1.2	2.2	0.8	-1.3	0.2	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.0	1.0	-0.7	-0.3	-0.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	-0.8	-0.2	0.4	0.1
Impedance of arm (left)	1.3	5.9	9.2	3.0	-3.0	1.2	-2.0
Arm fat mass (right)	0.5	2.1	5.4	-0.9	0.9	-1.1	-2.3
Trunk predicted mass	0.4	2.1	5.2	0.9	1.6	0.2	-2.3
Standing height	1.0	9.7	21.0	4.0	-1.1	0.8	-4.6
Length of working week for main job	1.5	1.7	3.5	-1.7	1.9	-0.6	-0.5
Exposure to tobacco smoke at home	0.6	0.7	2.0	-1.4	0.2	-0.7	-0.5
Breastfed as a baby	1.0	1.2	2.9	-1.0	-1.0	-1.7	0.1
Tense / ‘highly strung’	0.1	0.1	0.4	-0.1	-0.1	0.6	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.2	0.8	-1.5	0.4	-0.4
Hair/balding pattern: Pattern 4	1.4	3.5	7.8	1.1	2.8	1.3	1.7
Birth weight of first child	0.6	1.1	3.3	0.2	1.8	0.7	-0.7
Peak expiratory flow (PEF)	0.4	0.9	3.4	-0.1	1.9	0.4	-0.1
Pulse wave reflection index	0.8	1.0	2.6	1.1	0.5	1.6	0.2
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.4	0.1	1.8	0.7	-0.2
Loud music exposure frequency	0.1	0.1	0.3	0.1	0.3	-0.6	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.4	1.2	-0.6	0.3	-0.8
Mouth/teeth dental problems: Bleeding gums	2.1	2.8	4.0	-0.9	-2.0	-1.5	-2.0
Blood clot in the leg (DVT)	3.1	4.0	9.2	3.0	-1.3	1.8	1.4
Medication: Paracetamol	0.8	1.3	2.3	-0.8	1.2	-0.8	-1.5
Headache pain in last month	1.1	2.0	4.2	-0.4	1.8	-0.3	-2.0
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.7	1.1	-0.2	0.1	-2.2
Glaucoma (self-reported)	1.0	1.2	4.2	-0.3	0.7	-0.1	2.0
Gout (self-reported)	0.4	0.5	1.1	-0.5	0.4	-0.7	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.4	-1.2	-0.1	-0.3	0.2
Medication: Amlodipine	0.8	1.1	2.8	-0.4	-0.9	-1.7	0.6
Medication: Ventolin 100micrograms inhaler	1.5	2.0	3.4	-1.8	1.2	-1.1	-1.3
Birth weight	2.2	4.7	11.2	3.3	-1.0	2.4	-0.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.4	0.2	1.6	1.1	-0.0
High blood pressure (siblings)	2.6	3.8	7.9	-0.7	-1.0	-2.4	2.8
Forced vital capacity (FVC), Best measure	0.6	2.1	2.9	0.7	-1.6	-1.7	-1.6
Body fat percentage	0.6	2.5	8.0	-0.7	-0.0	-1.3	-2.8
Leg fat percentage (right)	0.7	2.7	4.2	-1.9	0.5	-2.1	-1.6
Arm fat-free mass (right)	0.6	3.1	8.1	0.4	2.0	0.0	-2.9
Exposure to tobacco smoke outside home	0.2	0.2	0.5	0.7	0.6	0.4	-0.1
Comparative body size at age 10	0.2	0.5	0.9	-0.1	-0.6	-0.9	0.9
Number of full brothers	0.3	0.3	0.6	0.7	-0.4	-0.6	0.6
Worry too long after embarrassment	0.5	0.8	2.2	-0.6	-1.5	-0.7	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.9	0.8	0.3	-0.3
Wheeze or whistling in the chest in last year	0.8	1.4	2.5	-1.2	-0.6	-1.1	-1.6
Number of children fathered	1.1	1.2	4.2	-0.2	0.6	-0.3	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.4	0.8	-0.5	0.5	1.6
Age at first live birth	0.9	1.6	3.1	1.8	-0.3	0.6	-1.6
Pulse wave peak to peak time	0.3	0.4	1.4	1.2	0.2	-0.2	-0.1
Health satisfaction	1.3	1.6	2.9	-1.5	1.1	-1.7	-0.4
Shortness of breath walking on level ground	0.4	0.5	1.8	-0.4	1.3	-0.4	-0.2
Qualifications: College or University degree	0.1	0.3	1.2	-0.1	-0.3	-0.2	-1.1
Eye problems/disorders: None of the above	3.3	3.9	6.8	2.6	-1.3	1.3	2.3
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.5	-0.9	-1.6	-1.5	0.2
Emphysema/chronic bronchitis	0.6	0.7	1.6	-0.7	-0.5	-1.3	0.5
Medication for pain relief, constipation, heartburn	1.3	2.2	3.7	1.7	-1.9	1.4	0.3
Neck or shoulder pain in last month	3.2	4.6	8.2	-2.9	1.4	-2.8	-0.3
Medication: Blood pressure	0.9	1.6	5.2	-1.0	0.2	0.3	2.3
Angina (self-reported)	1.9	2.6	9.9	-0.4	0.4	-0.1	3.1
Migraine (self-reported)	0.7	0.9	1.4	1.2	1.0	1.0	-0.4
Medication: Ibuprofen	2.8	3.4	10.2	-1.0	1.5	0.1	-3.2
Medication: Allopurinol	0.1	0.2	0.4	0.6	0.4	0.3	0.3
Medication: Omeprazole	1.0	1.2	3.5	-1.9	0.6	-0.8	0.4
Medication: Seretide 50 evohaler	1.7	2.0	4.3	-2.1	0.4	-1.1	-1.5
Mean time to correctly identify matches	0.6	1.1	1.8	1.3	-0.5	1.2	0.9
Heart disease (mother)	0.8	0.9	1.9	-1.4	0.5	-0.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.3	-0.0	0.2	1.3	1.8
Whole body fat mass	0.6	2.5	8.6	-0.3	0.6	-0.9	-2.9
Leg fat mass (right)	0.6	2.3	4.8	-1.2	0.8	-1.5	-2.2
Arm predicted mass (right)	0.5	2.7	7.7	0.0	1.7	-0.6	-2.8
Pulse rate, automated reading	0.9	3.0	8.9	-0.8	1.3	-0.7	3.0
Alcohol intake frequency.	0.4	1.0	2.8	-0.3	1.7	-1.0	0.2
Comparative height size at age 10	1.4	7.7	15.5	3.5	0.7	1.6	-3.9
Number of full sisters	0.1	0.1	0.4	-0.1	-0.0	-0.3	0.6
Suffer from ‘nerves’	0.1	0.1	0.4	-0.1	-0.6	-0.3	0.1
Overall health rating	1.0	2.1	4.3	-2.1	-0.3	-1.8	0.8
Chest pain or discomfort	1.4	2.1	4.5	-1.1	1.6	-0.4	2.1
Had major operations	0.4	0.4	1.1	-0.7	0.2	0.4	-1.0
Age at last live birth	3.0	4.3	7.2	2.7	-2.6	0.8	-1.7
Family relationship satisfaction	1.2	1.5	2.3	1.3	1.0	1.5	1.1
Leg pain on walking	0.7	0.8	2.0	-1.4	-0.3	-1.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.5	-0.1	-0.3	0.5
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.2	0.1	-0.1	-0.7	-1.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.5	0.4	-0.6	-0.2	1.6
Medication: Aspirin	0.5	0.7	1.2	-1.1	0.4	-1.0	0.7
Supplements: Vitamin C	0.7	0.9	1.8	1.3	-0.6	1.1	-0.3
Knee pain experienced in last month	0.2	0.4	0.7	-0.7	0.5	0.8	-0.1
Hypertension (Self-reported)	1.2	3.3	8.8	-0.9	-1.2	-1.4	3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.3	0.4	1.5	0.7	0.3
Illnesses of father: Heart disease	0.2	0.3	1.1	-0.3	-0.2	0.3	-1.0
Illnesses of siblings: Diabetes	0.3	0.4	1.5	0.1	-1.2	0.4	-0.1
Smoking status: Previous	0.3	0.5	0.9	0.4	-0.7	0.9	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.9	1.3	-0.2	-0.9	-2.2
Whole body fat-free mass	0.5	2.9	7.6	0.9	1.7	0.3	-2.8
Leg fat-free mass (right)	0.6	3.5	9.3	1.2	1.7	0.5	-3.0
Arm fat percentage (left)	0.5	2.1	6.7	-0.8	0.3	-0.9	-2.6
Average weekly red wine intake	2.6	3.9	7.3	2.7	0.4	1.9	-2.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.0	0.7	-1.4	-0.5	1.4
Mood swings	0.4	0.7	1.3	-0.9	0.7	-1.1	0.4
Loneliness, isolation	1.7	2.3	3.2	1.4	1.7	1.8	1.0
Long-standing illness, disability or infirmity	0.3	0.4	0.6	-0.6	0.7	-0.7	0.6
Ever had bowel cancer screening	0.7	0.8	1.8	-1.3	-0.1	-0.1	-1.1
Diabetes diagnosed by doctor	0.1	0.2	0.3	0.1	-0.5	0.3	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	-0.0	0.6	-0.7	-1.0
Friendships satisfaction	1.0	1.3	2.6	-0.5	1.6	-0.4	-1.5
Qualifications: nursing, teaching	0.7	1.0	1.5	-1.1	0.7	-0.9	-1.2
Commuting to job workplace: Walk	0.4	0.4	1.2	0.6	0.2	-0.2	1.1
Eye problems/disorders: Cataract	2.2	2.6	4.3	-1.8	1.5	-0.6	-2.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.1	0.7	-1.8	-0.4	0.8
Medication for cholesterol	1.5	2.3	6.1	0.7	1.3	2.5	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.7	-0.9	0.6	-1.3	-0.2
Back pain experienced in last month	0.6	0.9	3.2	0.2	-0.2	0.6	1.8
Mineral and other dietary supplements	0.9	1.2	2.1	-0.9	-1.4	-1.2	-0.5
Breast cancer (self-reported)	2.3	2.7	7.7	2.8	-0.6	1.1	1.2
Asthma (self-reported)	0.7	1.3	2.4	-1.5	-0.9	-1.3	-0.6
Osteoporosis (self-reported)	1.0	1.3	2.8	-1.0	-1.1	-1.7	0.3
Osteoarthritis (self-reported)	1.0	1.2	3.4	-0.6	1.1	0.1	-1.8
Medication: Aspirin	0.7	0.9	1.7	-1.3	-0.1	-1.3	0.6
Medication: Gliclazide	0.3	0.3	1.1	-0.2	-1.1	-0.3	-0.3
Illnesses of father: None of the above (group 1)	0.3	0.3	0.7	0.2	-0.9	0.3	0.7
Smoking status: Current	0.3	0.5	1.1	-0.0	-1.1	-0.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.8	-0.5	-1.3	-1.3	0.8
Whole body water mass	0.5	2.8	7.2	1.0	1.7	0.3	-2.7
Leg predicted mass (right)	0.6	3.3	9.0	1.2	1.6	0.5	-3.0
Arm fat mass (left)	0.6	2.5	7.7	-0.9	0.8	-1.0	-2.8
Number of self-reported non-cancer illnesses	0.9	1.5	3.3	-0.4	-1.3	-1.0	1.8
Average weekly champagne plus white wine intake	1.8	2.5	9.1	0.4	0.4	0.8	-3.0
Miserableness	0.7	1.2	3.0	-1.1	1.7	-0.3	0.7
Guilty feelings	0.6	0.9	2.8	-1.7	-0.4	0.6	-0.3
Wears glasses or contact lenses	0.7	0.8	1.9	-0.8	1.4	0.5	-0.7
Ever taken oral contraceptive pill	0.8	0.8	1.5	1.2	-1.0	0.0	0.9
Hearing aid user	3.7	4.2	11.9	-3.5	0.9	-1.8	-0.8
Mother’s age at death	1.0	1.3	3.4	0.9	-1.8	0.9	-0.0
Financial situation satisfaction	1.2	1.4	5.2	-0.3	2.3	0.6	0.3
Tinnitus: Yes, now most or all of the time	0.5	0.5	0.7	-0.6	-0.8	-0.6	-0.9
Commuting to job workplace: Public transport	0.3	0.3	0.9	0.4	-1.0	0.0	0.5
Eye problems/disorders: Glaucoma	1.5	1.8	3.8	-1.9	-0.2	-1.1	1.5
Medication: Blood pressure	1.4	2.6	4.6	0.2	-2.2	-1.9	1.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	0.2	-0.8	-0.7	0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	1.2	-0.1	0.6	-0.0
High cholesterol (Self-reported)	1.4	2.4	4.5	-2.0	-0.1	-2.1	1.1
Medication: Bendroflumethiazide	0.3	0.4	1.4	-0.5	0.1	-0.4	1.2
Medication: Paracetamol	0.8	1.3	2.9	-0.6	1.3	-0.4	-1.7
Medication: Lisinopril	0.2	0.3	0.8	-0.5	-0.2	-0.0	0.9
Medication: Atorvastatin	1.5	1.9	5.3	-0.9	-0.3	-1.1	2.3
Illnesses of father: High blood pressure	0.6	0.7	1.8	0.8	-0.7	-0.2	1.4
Alcohol drinker status: Never	0.8	0.9	2.0	0.8	1.4	1.1	-0.0
Ever smoked	1.0	1.7	3.2	1.0	-1.8	1.5	0.3
Basal metabolic rate	0.5	3.0	9.3	0.8	1.5	0.0	-3.0
Leg fat percentage (left)	0.6	2.2	3.4	-1.6	0.4	-1.8	-1.7
Arm fat-free mass (left)	0.4	2.3	5.6	0.0	1.8	-0.4	-2.4
Number of operations (self-reported)	0.1	0.2	0.6	-0.3	0.1	-0.4	0.8
Average weekly beer plus cider intake	1.6	2.2	3.1	-1.5	-1.8	-1.5	1.2
Irritability	0.1	0.1	0.2	0.3	0.2	0.2	0.5
Risk taking	0.6	0.9	2.0	-0.3	1.1	-0.5	-1.4
Ever had prostate specific antigen (PSA) test	1.4	1.6	6.0	0.3	0.4	0.2	-2.5
Fractured/broken bones in last 5 years	0.7	0.9	3.4	-0.0	-0.1	0.2	1.8
Age started oral contraceptive pill	0.7	0.8	1.9	1.4	-0.1	0.2	1.2
Diastolic blood pressure, automated reading	0.8	2.4	5.1	-1.3	-0.2	-1.6	2.3
Ever depressed for a whole week	0.8	1.0	1.7	-0.5	1.3	1.1	-0.9
Unable to work because of sickness or disability	1.2	1.6	3.2	-1.7	0.4	-1.8	-0.1
Commuting to job workplace: Cycle	0.8	1.0	1.3	-1.1	0.9	0.9	-1.1
Myopia	0.5	0.7	2.3	0.4	1.5	-0.4	-0.4
Vascular/heart problems diagnosed by doctor	1.3	3.6	11.0	0.9	0.8	1.4	-3.3
Cholesterol lowering medication	3.1	4.5	8.8	-1.9	-2.3	-3.0	0.8
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.7	-1.6	0.5	-0.8	0.6
Pain experienced in last month	0.1	0.2	0.4	0.1	-0.6	-0.5	0.1
Supplements: Calcium	0.9	1.0	1.3	0.9	1.1	1.2	0.8
Basal cell carcinoma (self-reported)	0.7	0.9	3.2	-0.0	-0.3	-0.4	-1.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.8	0.4	-0.3	0.3	1.7
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	7.4	2.7	-1.1	1.5	1.1
Heart disease (siblings)	0.3	0.4	1.4	0.4	-1.2	-0.2	-0.1
Alcohol drinker status: Previous	0.3	0.3	0.6	0.7	0.3	-0.5	0.7
Pack years of smoking	3.0	4.5	10.0	-3.2	1.3	-2.5	-0.1
Impedance of whole body	0.6	3.2	7.3	1.8	-2.7	0.1	-1.4
Leg fat mass (left)	0.5	2.0	4.5	-1.0	0.6	-1.5	-2.1
Arm predicted mass (left)	0.4	2.2	5.6	0.3	1.8	-0.2	-2.4