Hub : Genes

CROCCP3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0960 0.0310 2.3e-06 0.027 0.056 0.043 0.053 0.039 2.7e-04 2.3e-07 5.1e-06 5.0e-07 1.4e-05
2 GTEx Skin Sun Exposed Lower leg 0.1110 0.0420 4.2e-04 0.112 NA 0.079 NA 0.095 1.6e-09 NA 4.1e-07 NA 2.8e-08
3 GTEx Testis 0.0650 0.0330 9.2e-03 0.029 NA 0.003 NA 0.017 2.0e-02 NA 2.2e-01 NA 5.9e-02
4 ROSMAP Brain Pre-frontal Cortex 0.0774 0.0283 3.3e-04 0.010 0.020 0.001 0.020 0.002 1.8e-02 1.0e-03 2.5e-01 1.1e-03 1.5e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.3 0.4 0.8 -0.9 -0.4 -0.9 -0.3
Bipolar Disorder or Schizophrenia 0.9 2.2 4.7 -2.2 1.2 -1.7 0.2
Depressed Affect (Nagel 2018) 0.5 1.0 2.0 -1.4 1.4 -0.3 0.5
Depression (Nagel 2018) 1.1 1.6 2.7 -1.6 1.6 1.0 -0.5
Intelligence (Savage-Jansen 2018) 0.5 1.6 3.5 -1.9 -1.4 -1.1 0.1
Neuroticism (Nagel 2018) 0.3 0.7 2.0 -1.4 -0.3 -0.9 -0.3
Schizophrenia (2018) 1.2 2.5 4.3 -2.1 1.8 -1.5 0.5
Schizophrenia vs Biploar Disorder 1.2 1.5 2.9 0.9 1.7 1.3 0.9
Worry (Nagel 2018) 0.4 0.9 1.4 -1.1 -0.9 -0.5 -1.2
Alzheimer’s Disease (in mother) 0.8 0.9 2.0 -0.9 1.4 -0.8 -0.4
Alzheimer’s Disease (in father) 2.3 2.5 6.4 1.7 0.7 2.5 0.5
Alzheimer’s Disease (including proxy) 0.6 0.9 2.7 -0.7 1.6 0.0 -0.5
Crohns Disease (2017) 0.7 1.6 2.6 1.6 0.5 1.3 -1.4
Irritable Bowel Disease (IBD) 0.5 1.1 1.4 1.1 1.0 1.0 -1.2
Ulcerative Colitis (UC) 0.1 0.2 0.5 0.5 0.7 0.2 0.0
Major Depression (MDD) 0.3 0.3 0.8 0.9 -0.5 -0.1 -0.5
Reaction Time 1.0 2.0 3.4 1.8 0.2 1.4 1.5
Verbal and Numeric Reasoning (VNR) 0.4 1.0 1.6 -1.3 -0.9 -1.1 0.5
Breast Cancer 0.5 1.3 2.6 -1.1 0.6 -0.9 1.6
Ovarian Cancer 0.3 0.4 0.6 0.8 -0.7 0.6 -0.3
Prostate Cancer 0.7 1.0 2.6 -0.1 -0.5 1.6 -1.0
Age at First Birth 0.9 1.3 2.0 1.2 0.0 1.4 -1.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 1.7 0.2 0.9 0.9 -1.3
Coronary Artery Disease (CAD) 0.6 0.7 2.0 -1.4 -0.1 -0.9 0.2
Crohns Disease (2012) 1.0 1.6 4.0 2.0 -0.8 1.0 -0.9
Mean Putamen Volume 1.3 1.4 3.2 -1.8 -0.0 -0.9 -1.3
Fasting Glucose 0.8 1.0 3.3 -0.7 1.8 -0.3 0.4
HbA1C 0.8 0.9 1.3 0.6 1.0 1.0 1.2
HDL Cholesterol 0.4 0.7 2.5 -1.6 0.2 -0.6 0.2
LDL Cholesterol 1.4 2.3 4.5 -1.0 -0.2 -1.9 2.1
Lupus 0.3 0.4 0.7 0.1 0.8 0.8 -0.5
Neuroticism (2016) 0.3 0.5 0.8 0.6 0.2 0.9 0.7
Primary Biliary Cirrhosis 1.1 1.6 5.2 -0.4 -0.7 -0.7 -2.3
Rheumatoid Arthritis 0.9 1.2 3.2 -0.4 -1.1 -1.8 -0.1
Schizophrenia (2014) 0.5 1.1 2.8 -1.0 1.7 -0.6 0.5
Triglycerides 1.2 2.0 3.8 -0.3 -1.3 -2.0 1.5
Type 2 Diabetes (T2D) (2012) 2.6 3.0 7.4 0.6 -2.7 -1.6 -1.3
Ulcerative Colitis 0.1 0.1 0.4 -0.2 0.6 0.0 0.1
Blood Eosinophil Count 0.2 1.3 4.2 -0.2 0.3 1.0 -2.0
Blood Platelet Count 0.2 1.8 3.0 0.7 1.5 1.3 -1.7
Blood Red Count 0.2 2.4 5.6 -1.5 -0.9 -2.4 1.0
Blood White Count 0.1 0.7 2.4 -0.3 0.5 -0.4 1.6
Heel T-Score 1.6 12.6 18.0 4.2 2.1 3.3 -4.1
BMI 0.8 4.6 10.2 -3.2 1.1 -2.3 -1.2
Height 0.8 16.0 35.5 6.0 -3.2 1.0 -4.2
Waist Hip Ratio (WHR) 0.5 2.2 3.3 -1.2 -1.8 -1.5 -1.4
Systolic Blood Pressure 0.9 4.4 12.1 -1.5 -0.7 -1.7 3.5
Smoking Status 0.6 1.5 2.6 -1.2 -1.6 -1.3 0.6
Allergy or Eczema 0.7 1.9 4.5 -2.1 -0.8 -0.7 -1.4
Cardiovascular Disease 1.9 6.4 10.0 -3.2 -1.2 -2.9 2.4
Hypothyroidism (self reported) 0.3 0.6 2.2 -1.5 -0.0 -0.3 0.5
Respiratory disease 0.6 1.2 1.6 -1.0 -1.3 -1.0 -1.2
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.5 -0.7 -0.1 0.5 -0.2
Lung FEV1/FVC ratio 3.1 15.7 32.8 3.1 3.0 5.7 3.4
Lung FVC 1.3 6.4 17.9 -2.3 -1.4 -4.2 0.5
Neuroticism 0.2 0.5 1.4 -1.2 0.3 -0.6 -0.1
Chronotype (morning person) 1.7 4.0 7.9 2.4 0.1 2.8 1.5
Hair Pigment 0.1 3.8 12.0 1.7 0.1 0.5 -3.5
Tanning 0.2 2.7 5.8 1.8 1.2 2.4 0.7
Hand grip strength (left) 0.4 1.0 2.1 1.1 -0.1 0.7 -1.4
Number of treatments/medications taken 1.0 1.9 4.7 -2.2 0.8 -1.2 0.8
Average weekly spirits intake 0.7 0.8 2.6 -0.1 -1.6 -0.4 0.8
Sensitivity / hurt feelings 0.7 1.2 1.8 1.4 -1.1 0.5 1.3
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.7 -0.3 1.9 1.2 0.6
Hearing difficulty/problems: Yes 1.5 2.3 4.8 -1.1 -1.7 -2.2 -0.6
Relative age of first facial hair 1.2 2.5 5.8 2.0 -0.2 0.7 2.4
Other serious medical condition/disability diagnosed by doctor 2.5 3.3 6.0 -2.4 1.1 -2.4 0.6
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.2 -0.3 -0.4 -1.1 0.8
Ever had hysterectomy (womb removed) 1.0 1.2 3.3 -0.9 1.8 -0.7 0.2
Systolic blood pressure, automated reading 1.1 3.3 11.0 -1.1 -0.9 -0.2 3.3
Eye problems/disorders: Diabetes related eye disease 0.9 0.9 3.2 0.6 -0.1 0.4 -1.8
Angina 2.0 2.7 10.0 -0.4 0.6 0.0 3.2
Medication for hormone replacement therapy 0.4 0.4 0.6 -0.4 0.5 -0.8 0.8
Vitamin and mineral supplements 2.5 3.3 5.7 -2.0 -1.8 -2.4 0.7
Supplements: Zinc 1.2 1.3 2.7 0.4 -1.6 0.2 -1.6
Medication: Co-codamol 1.5 1.7 4.0 -1.4 2.0 0.4 1.0
Medication: Metformin 0.1 0.1 0.1 -0.3 -0.3 0.3 -0.1
Diabetes (father) 1.5 1.9 3.5 -1.9 0.2 -0.8 -1.9
Diabetes (mother) 0.1 0.1 0.3 0.3 0.2 -0.6 0.1
Severe depression (siblings) 1.0 1.2 2.4 1.5 0.0 1.5 0.3
Pack years adult smoking proportion 2.7 4.1 9.0 -3.0 1.1 -2.5 -0.0
Impedance of leg (right) 0.4 1.9 6.5 0.4 -2.5 -1.1 -0.2
Leg fat-free mass (left) 0.6 3.3 9.7 1.0 1.6 0.4 -3.1
Trunk fat percentage 0.7 2.7 9.8 0.0 -0.3 -0.8 -3.1
Hand grip strength (right) 0.4 1.2 3.7 0.3 0.8 0.4 -1.9
Townsend deprivation index at recruitment 0.7 1.0 1.4 1.1 1.2 0.4 1.0
Current tobacco smoking 0.4 0.7 1.1 -0.5 -0.8 -1.1 0.8
Average weekly fortified wine intake 0.2 0.3 0.6 0.8 0.4 0.4 -0.3
Maternal smoking around birth 0.2 0.2 0.7 -0.1 -0.4 0.9 0.3
Fed-up feelings 0.8 1.4 4.0 1.0 0.7 0.3 2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 4.1 -0.4 2.0 2.0 -0.5
Relative age voice broke 1.0 1.5 2.8 1.7 -0.2 1.7 -0.8
Taking other prescription medications 1.0 1.5 4.5 -1.2 0.2 -0.4 2.1
Age when periods started (menarche) 0.8 2.0 5.8 -0.5 -2.4 -1.1 0.9
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.9 1.7 -0.6 0.5 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.6 7.0 2.1 2.2 1.5 -2.6
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.3 0.1 -1.1 -0.1 0.8
Qualifications: CSEs or equivalent 1.1 1.5 5.1 0.8 2.3 -0.3 -0.4
Serious illness, injury or assault to yourself 0.3 0.3 0.9 -0.9 -0.1 -0.6 -0.3
High blood pressure 1.5 4.1 9.1 -1.4 -1.3 -1.9 3.0
Hayfever, allergic rhinitis or eczema 1.0 2.1 3.9 -1.7 -0.9 -0.7 -2.0
Multivitamins +/- minerals 1.9 2.4 3.7 1.4 1.6 1.9 -1.2
Stomach or abdominal pain in last month 0.4 0.4 0.5 -0.6 -0.7 -0.7 0.6
Supplements: Glucosamine 1.2 1.5 3.4 1.6 0.5 1.9 -0.1
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.3 0.6 -0.3 -0.3 0.4
Medication: Atenolol 0.8 1.0 2.0 1.2 -0.2 -0.6 1.4
Medication: Levothyroxine sodium 0.1 0.2 0.3 -0.5 -0.5 -0.2 0.5
Sitting height 0.3 1.8 4.1 2.0 0.8 0.1 -1.5
Chronic bronchitis/emphysema (father) 0.5 0.6 1.2 -0.8 0.1 -1.1 0.7
High blood pressure (mother) 0.9 1.3 1.7 -1.2 -0.6 -1.2 1.3
Body mass index (BMI) 0.7 2.8 4.7 -2.2 1.6 -1.4 -1.5
Impedance of leg (left) 0.5 2.3 8.0 0.6 -2.8 -0.9 -0.3
Leg predicted mass (left) 0.6 3.4 9.8 1.1 1.5 0.4 -3.1
Trunk fat mass 0.7 2.9 10.9 0.3 0.3 -0.6 -3.3
Waist circumference 1.1 4.1 9.4 -1.8 0.3 -2.0 -3.1
Number of incorrect matches in round 1.0 1.6 2.8 0.3 -1.7 -1.1 1.5
Past tobacco smoking 0.8 1.4 2.5 -1.0 1.6 -1.4 0.4
Alcohol usually taken with meals 1.1 1.8 4.4 0.6 1.4 0.5 -2.1
Nervous feelings 0.7 1.3 2.7 -0.3 -1.6 -1.1 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.9 0.6 1.4 0.3 0.8
Hearing difficulty/problems with background noise 0.5 0.9 2.3 -0.5 -0.9 -1.5 0.3
Hair/balding pattern: Pattern 2 0.6 0.8 1.9 -0.4 0.5 -0.8 -1.4
Had menopause 1.0 1.2 4.9 0.0 -0.2 0.0 2.2
Had other major operations 0.5 0.6 2.0 0.3 -0.3 -1.4 0.4
Forced vital capacity (FVC) 0.7 2.8 5.8 0.7 -2.1 -2.4 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 2.9 6.6 18.2 1.7 1.9 1.3 -4.3
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 6.3 -1.1 0.8 0.4 -2.5
Qualifications: None of the above 0.8 1.6 5.2 -2.3 -0.0 -0.8 0.8
Financial difficulties in last 2 years 2.1 2.8 9.2 -1.3 3.0 -0.3 -0.5
Mouth/teeth dental problems 1.2 1.9 6.6 0.1 2.6 0.7 -0.6
Heart attack 0.4 0.6 2.0 0.3 -0.1 0.4 1.4
Allergy 0.6 1.3 2.4 1.1 1.2 0.5 1.6
Pain all over the body in last month 0.5 0.5 1.3 -0.2 0.0 -1.1 0.8
Diabetes (self-reported) 0.7 1.1 4.1 0.4 -2.0 -0.4 -0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.2 -1.1 0.6 0.1 -0.4
Medication: Ramipril 0.9 1.1 2.5 -0.1 -0.8 -1.2 1.6
Medication: Simvastatin 1.5 2.2 3.5 -1.9 -1.3 -1.7 0.8
Fluid intelligence score 0.6 1.3 2.6 -0.2 -1.6 -1.0 1.3
Illnesses of siblings 1.9 2.6 3.9 0.2 1.9 2.0 -1.7
Neuroticism score 0.1 0.3 0.4 -0.7 0.3 -0.4 0.6
Weight 0.7 3.3 11.6 -0.2 0.9 -0.9 -3.4
Impedance of arm (right) 0.9 4.3 7.7 2.7 -2.8 1.2 -1.0
Arm fat percentage (right) 0.4 1.7 5.1 -0.9 0.3 -0.9 -2.3
Trunk fat-free mass 0.4 2.2 5.6 0.8 1.6 0.1 -2.4
Hip circumference 0.9 4.1 11.5 -0.9 1.1 -1.6 -3.4
Time employed in main current job 0.3 0.4 1.2 -0.2 0.3 -0.5 -1.1
Alcohol intake versus 10 years previously 0.7 1.1 2.9 0.2 -1.1 -0.3 1.7
Father’s age at death 0.2 0.2 0.6 0.8 0.1 0.3 -0.5
Worrier / anxious feelings 0.1 0.1 0.2 -0.4 0.2 0.1 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 3.3 -1.0 1.8 -0.3 0.4
Falls in the last year 0.8 1.1 1.5 -1.2 1.2 -1.0 0.5
Hair/balding pattern: Pattern 3 0.8 1.3 2.5 1.5 0.2 1.6 0.5
Number of live births 0.2 0.3 0.9 -1.0 -0.1 0.1 -0.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 1.2 1.1 -0.7 -0.7 -0.2
Pulse rate 0.8 1.4 4.4 -0.7 0.5 -0.6 2.1
Happiness 0.4 0.4 1.1 -0.5 1.0 -0.5 0.4
Noisy workplace 0.2 0.2 0.4 -0.4 0.1 -0.6 0.5
Qualifications: A levels/AS levels or equivalent 1.1 2.5 7.7 -0.9 1.1 -0.5 -2.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.5 0.6 -0.0 -0.5
Mouth/teeth dental problems: Dentures 0.8 1.4 2.5 0.8 -0.5 1.4 1.6
Asthma 0.8 1.5 2.9 -1.7 -0.9 -1.4 -0.6
Medication: Ibuprofen (e.g. Nurofen) 2.2 2.8 7.2 -0.6 1.9 0.3 -2.7
Medication: Cholesterol lowering 0.4 0.6 1.8 -0.3 -0.6 0.1 1.4
Depression (self-reported) 0.3 0.3 0.6 0.8 0.0 0.6 0.6
Medication: Lansoprazole 1.3 1.4 3.8 -1.2 0.6 -1.9 0.3
Prospective memory result 1.9 2.4 5.3 2.3 0.6 1.9 -0.5
Lung cancer (father) 0.4 0.5 1.1 1.0 0.2 1.0 -0.1
Illnesses of mother 0.9 1.2 2.2 0.8 -1.3 0.2 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.0 1.0 -0.7 -0.3 -0.8
Pulse wave Arterial Stiffness index 0.2 0.2 0.7 -0.8 -0.2 0.4 0.1
Impedance of arm (left) 1.3 5.9 9.2 3.0 -3.0 1.2 -2.0
Arm fat mass (right) 0.5 2.1 5.4 -0.9 0.9 -1.1 -2.3
Trunk predicted mass 0.4 2.1 5.2 0.9 1.6 0.2 -2.3
Standing height 1.0 9.7 21.0 4.0 -1.1 0.8 -4.6
Length of working week for main job 1.5 1.7 3.5 -1.7 1.9 -0.6 -0.5
Exposure to tobacco smoke at home 0.6 0.7 2.0 -1.4 0.2 -0.7 -0.5
Breastfed as a baby 1.0 1.2 2.9 -1.0 -1.0 -1.7 0.1
Tense / ‘highly strung’ 0.1 0.1 0.4 -0.1 -0.1 0.6 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.2 0.8 -1.5 0.4 -0.4
Hair/balding pattern: Pattern 4 1.4 3.5 7.8 1.1 2.8 1.3 1.7
Birth weight of first child 0.6 1.1 3.3 0.2 1.8 0.7 -0.7
Peak expiratory flow (PEF) 0.4 0.9 3.4 -0.1 1.9 0.4 -0.1
Pulse wave reflection index 0.8 1.0 2.6 1.1 0.5 1.6 0.2
Ever highly irritable/argumentative for 2 days 0.8 1.0 3.4 0.1 1.8 0.7 -0.2
Loud music exposure frequency 0.1 0.1 0.3 0.1 0.3 -0.6 0.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.4 1.2 -0.6 0.3 -0.8
Mouth/teeth dental problems: Bleeding gums 2.1 2.8 4.0 -0.9 -2.0 -1.5 -2.0
Blood clot in the leg (DVT) 3.1 4.0 9.2 3.0 -1.3 1.8 1.4
Medication: Paracetamol 0.8 1.3 2.3 -0.8 1.2 -0.8 -1.5
Headache pain in last month 1.1 2.0 4.2 -0.4 1.8 -0.3 -2.0
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 4.7 1.1 -0.2 0.1 -2.2
Glaucoma (self-reported) 1.0 1.2 4.2 -0.3 0.7 -0.1 2.0
Gout (self-reported) 0.4 0.5 1.1 -0.5 0.4 -0.7 -1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.4 -1.2 -0.1 -0.3 0.2
Medication: Amlodipine 0.8 1.1 2.8 -0.4 -0.9 -1.7 0.6
Medication: Ventolin 100micrograms inhaler 1.5 2.0 3.4 -1.8 1.2 -1.1 -1.3
Birth weight 2.2 4.7 11.2 3.3 -1.0 2.4 -0.9
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.4 0.2 1.6 1.1 -0.0
High blood pressure (siblings) 2.6 3.8 7.9 -0.7 -1.0 -2.4 2.8
Forced vital capacity (FVC), Best measure 0.6 2.1 2.9 0.7 -1.6 -1.7 -1.6
Body fat percentage 0.6 2.5 8.0 -0.7 -0.0 -1.3 -2.8
Leg fat percentage (right) 0.7 2.7 4.2 -1.9 0.5 -2.1 -1.6
Arm fat-free mass (right) 0.6 3.1 8.1 0.4 2.0 0.0 -2.9
Exposure to tobacco smoke outside home 0.2 0.2 0.5 0.7 0.6 0.4 -0.1
Comparative body size at age 10 0.2 0.5 0.9 -0.1 -0.6 -0.9 0.9
Number of full brothers 0.3 0.3 0.6 0.7 -0.4 -0.6 0.6
Worry too long after embarrassment 0.5 0.8 2.2 -0.6 -1.5 -0.7 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.9 -0.9 0.8 0.3 -0.3
Wheeze or whistling in the chest in last year 0.8 1.4 2.5 -1.2 -0.6 -1.1 -1.6
Number of children fathered 1.1 1.2 4.2 -0.2 0.6 -0.3 -2.0
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.4 0.8 -0.5 0.5 1.6
Age at first live birth 0.9 1.6 3.1 1.8 -0.3 0.6 -1.6
Pulse wave peak to peak time 0.3 0.4 1.4 1.2 0.2 -0.2 -0.1
Health satisfaction 1.3 1.6 2.9 -1.5 1.1 -1.7 -0.4
Shortness of breath walking on level ground 0.4 0.5 1.8 -0.4 1.3 -0.4 -0.2
Qualifications: College or University degree 0.1 0.3 1.2 -0.1 -0.3 -0.2 -1.1
Eye problems/disorders: None of the above 3.3 3.9 6.8 2.6 -1.3 1.3 2.3
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.5 -0.9 -1.6 -1.5 0.2
Emphysema/chronic bronchitis 0.6 0.7 1.6 -0.7 -0.5 -1.3 0.5
Medication for pain relief, constipation, heartburn 1.3 2.2 3.7 1.7 -1.9 1.4 0.3
Neck or shoulder pain in last month 3.2 4.6 8.2 -2.9 1.4 -2.8 -0.3
Medication: Blood pressure 0.9 1.6 5.2 -1.0 0.2 0.3 2.3
Angina (self-reported) 1.9 2.6 9.9 -0.4 0.4 -0.1 3.1
Migraine (self-reported) 0.7 0.9 1.4 1.2 1.0 1.0 -0.4
Medication: Ibuprofen 2.8 3.4 10.2 -1.0 1.5 0.1 -3.2
Medication: Allopurinol 0.1 0.2 0.4 0.6 0.4 0.3 0.3
Medication: Omeprazole 1.0 1.2 3.5 -1.9 0.6 -0.8 0.4
Medication: Seretide 50 evohaler 1.7 2.0 4.3 -2.1 0.4 -1.1 -1.5
Mean time to correctly identify matches 0.6 1.1 1.8 1.3 -0.5 1.2 0.9
Heart disease (mother) 0.8 0.9 1.9 -1.4 0.5 -0.9 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.3 -0.0 0.2 1.3 1.8
Whole body fat mass 0.6 2.5 8.6 -0.3 0.6 -0.9 -2.9
Leg fat mass (right) 0.6 2.3 4.8 -1.2 0.8 -1.5 -2.2
Arm predicted mass (right) 0.5 2.7 7.7 0.0 1.7 -0.6 -2.8
Pulse rate, automated reading 0.9 3.0 8.9 -0.8 1.3 -0.7 3.0
Alcohol intake frequency. 0.4 1.0 2.8 -0.3 1.7 -1.0 0.2
Comparative height size at age 10 1.4 7.7 15.5 3.5 0.7 1.6 -3.9
Number of full sisters 0.1 0.1 0.4 -0.1 -0.0 -0.3 0.6
Suffer from ‘nerves’ 0.1 0.1 0.4 -0.1 -0.6 -0.3 0.1
Overall health rating 1.0 2.1 4.3 -2.1 -0.3 -1.8 0.8
Chest pain or discomfort 1.4 2.1 4.5 -1.1 1.6 -0.4 2.1
Had major operations 0.4 0.4 1.1 -0.7 0.2 0.4 -1.0
Age at last live birth 3.0 4.3 7.2 2.7 -2.6 0.8 -1.7
Family relationship satisfaction 1.2 1.5 2.3 1.3 1.0 1.5 1.1
Leg pain on walking 0.7 0.8 2.0 -1.4 -0.3 -1.1 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 0.5 -0.1 -0.3 0.5
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.2 0.1 -0.1 -0.7 -1.5
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.5 0.4 -0.6 -0.2 1.6
Medication: Aspirin 0.5 0.7 1.2 -1.1 0.4 -1.0 0.7
Supplements: Vitamin C 0.7 0.9 1.8 1.3 -0.6 1.1 -0.3
Knee pain experienced in last month 0.2 0.4 0.7 -0.7 0.5 0.8 -0.1
Hypertension (Self-reported) 1.2 3.3 8.8 -0.9 -1.2 -1.4 3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.3 0.4 1.5 0.7 0.3
Illnesses of father: Heart disease 0.2 0.3 1.1 -0.3 -0.2 0.3 -1.0
Illnesses of siblings: Diabetes 0.3 0.4 1.5 0.1 -1.2 0.4 -0.1
Smoking status: Previous 0.3 0.5 0.9 0.4 -0.7 0.9 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 4.9 1.3 -0.2 -0.9 -2.2
Whole body fat-free mass 0.5 2.9 7.6 0.9 1.7 0.3 -2.8
Leg fat-free mass (right) 0.6 3.5 9.3 1.2 1.7 0.5 -3.0
Arm fat percentage (left) 0.5 2.1 6.7 -0.8 0.3 -0.9 -2.6
Average weekly red wine intake 2.6 3.9 7.3 2.7 0.4 1.9 -2.1
Handedness (chirality/laterality): Left-handed 1.0 1.2 2.0 0.7 -1.4 -0.5 1.4
Mood swings 0.4 0.7 1.3 -0.9 0.7 -1.1 0.4
Loneliness, isolation 1.7 2.3 3.2 1.4 1.7 1.8 1.0
Long-standing illness, disability or infirmity 0.3 0.4 0.6 -0.6 0.7 -0.7 0.6
Ever had bowel cancer screening 0.7 0.8 1.8 -1.3 -0.1 -0.1 -1.1
Diabetes diagnosed by doctor 0.1 0.2 0.3 0.1 -0.5 0.3 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.9 -0.0 0.6 -0.7 -1.0
Friendships satisfaction 1.0 1.3 2.6 -0.5 1.6 -0.4 -1.5
Qualifications: nursing, teaching 0.7 1.0 1.5 -1.1 0.7 -0.9 -1.2
Commuting to job workplace: Walk 0.4 0.4 1.2 0.6 0.2 -0.2 1.1
Eye problems/disorders: Cataract 2.2 2.6 4.3 -1.8 1.5 -0.6 -2.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.1 0.7 -1.8 -0.4 0.8
Medication for cholesterol 1.5 2.3 6.1 0.7 1.3 2.5 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.7 -0.9 0.6 -1.3 -0.2
Back pain experienced in last month 0.6 0.9 3.2 0.2 -0.2 0.6 1.8
Mineral and other dietary supplements 0.9 1.2 2.1 -0.9 -1.4 -1.2 -0.5
Breast cancer (self-reported) 2.3 2.7 7.7 2.8 -0.6 1.1 1.2
Asthma (self-reported) 0.7 1.3 2.4 -1.5 -0.9 -1.3 -0.6
Osteoporosis (self-reported) 1.0 1.3 2.8 -1.0 -1.1 -1.7 0.3
Osteoarthritis (self-reported) 1.0 1.2 3.4 -0.6 1.1 0.1 -1.8
Medication: Aspirin 0.7 0.9 1.7 -1.3 -0.1 -1.3 0.6
Medication: Gliclazide 0.3 0.3 1.1 -0.2 -1.1 -0.3 -0.3
Illnesses of father: None of the above (group 1) 0.3 0.3 0.7 0.2 -0.9 0.3 0.7
Smoking status: Current 0.3 0.5 1.1 -0.0 -1.1 -0.6 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 1.8 -0.5 -1.3 -1.3 0.8
Whole body water mass 0.5 2.8 7.2 1.0 1.7 0.3 -2.7
Leg predicted mass (right) 0.6 3.3 9.0 1.2 1.6 0.5 -3.0
Arm fat mass (left) 0.6 2.5 7.7 -0.9 0.8 -1.0 -2.8
Number of self-reported non-cancer illnesses 0.9 1.5 3.3 -0.4 -1.3 -1.0 1.8
Average weekly champagne plus white wine intake 1.8 2.5 9.1 0.4 0.4 0.8 -3.0
Miserableness 0.7 1.2 3.0 -1.1 1.7 -0.3 0.7
Guilty feelings 0.6 0.9 2.8 -1.7 -0.4 0.6 -0.3
Wears glasses or contact lenses 0.7 0.8 1.9 -0.8 1.4 0.5 -0.7
Ever taken oral contraceptive pill 0.8 0.8 1.5 1.2 -1.0 0.0 0.9
Hearing aid user 3.7 4.2 11.9 -3.5 0.9 -1.8 -0.8
Mother’s age at death 1.0 1.3 3.4 0.9 -1.8 0.9 -0.0
Financial situation satisfaction 1.2 1.4 5.2 -0.3 2.3 0.6 0.3
Tinnitus: Yes, now most or all of the time 0.5 0.5 0.7 -0.6 -0.8 -0.6 -0.9
Commuting to job workplace: Public transport 0.3 0.3 0.9 0.4 -1.0 0.0 0.5
Eye problems/disorders: Glaucoma 1.5 1.8 3.8 -1.9 -0.2 -1.1 1.5
Medication: Blood pressure 1.4 2.6 4.6 0.2 -2.2 -1.9 1.4
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.6 0.2 -0.8 -0.7 0.6
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.5 1.2 -0.1 0.6 -0.0
High cholesterol (Self-reported) 1.4 2.4 4.5 -2.0 -0.1 -2.1 1.1
Medication: Bendroflumethiazide 0.3 0.4 1.4 -0.5 0.1 -0.4 1.2
Medication: Paracetamol 0.8 1.3 2.9 -0.6 1.3 -0.4 -1.7
Medication: Lisinopril 0.2 0.3 0.8 -0.5 -0.2 -0.0 0.9
Medication: Atorvastatin 1.5 1.9 5.3 -0.9 -0.3 -1.1 2.3
Illnesses of father: High blood pressure 0.6 0.7 1.8 0.8 -0.7 -0.2 1.4
Alcohol drinker status: Never 0.8 0.9 2.0 0.8 1.4 1.1 -0.0
Ever smoked 1.0 1.7 3.2 1.0 -1.8 1.5 0.3
Basal metabolic rate 0.5 3.0 9.3 0.8 1.5 0.0 -3.0
Leg fat percentage (left) 0.6 2.2 3.4 -1.6 0.4 -1.8 -1.7
Arm fat-free mass (left) 0.4 2.3 5.6 0.0 1.8 -0.4 -2.4
Number of operations (self-reported) 0.1 0.2 0.6 -0.3 0.1 -0.4 0.8
Average weekly beer plus cider intake 1.6 2.2 3.1 -1.5 -1.8 -1.5 1.2
Irritability 0.1 0.1 0.2 0.3 0.2 0.2 0.5
Risk taking 0.6 0.9 2.0 -0.3 1.1 -0.5 -1.4
Ever had prostate specific antigen (PSA) test 1.4 1.6 6.0 0.3 0.4 0.2 -2.5
Fractured/broken bones in last 5 years 0.7 0.9 3.4 -0.0 -0.1 0.2 1.8
Age started oral contraceptive pill 0.7 0.8 1.9 1.4 -0.1 0.2 1.2
Diastolic blood pressure, automated reading 0.8 2.4 5.1 -1.3 -0.2 -1.6 2.3
Ever depressed for a whole week 0.8 1.0 1.7 -0.5 1.3 1.1 -0.9
Unable to work because of sickness or disability 1.2 1.6 3.2 -1.7 0.4 -1.8 -0.1
Commuting to job workplace: Cycle 0.8 1.0 1.3 -1.1 0.9 0.9 -1.1
Myopia 0.5 0.7 2.3 0.4 1.5 -0.4 -0.4
Vascular/heart problems diagnosed by doctor 1.3 3.6 11.0 0.9 0.8 1.4 -3.3
Cholesterol lowering medication 3.1 4.5 8.8 -1.9 -2.3 -3.0 0.8
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.7 -1.6 0.5 -0.8 0.6
Pain experienced in last month 0.1 0.2 0.4 0.1 -0.6 -0.5 0.1
Supplements: Calcium 0.9 1.0 1.3 0.9 1.1 1.2 0.8
Basal cell carcinoma (self-reported) 0.7 0.9 3.2 -0.0 -0.3 -0.4 -1.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.8 0.4 -0.3 0.3 1.7
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 7.4 2.7 -1.1 1.5 1.1
Heart disease (siblings) 0.3 0.4 1.4 0.4 -1.2 -0.2 -0.1
Alcohol drinker status: Previous 0.3 0.3 0.6 0.7 0.3 -0.5 0.7
Pack years of smoking 3.0 4.5 10.0 -3.2 1.3 -2.5 -0.1
Impedance of whole body 0.6 3.2 7.3 1.8 -2.7 0.1 -1.4
Leg fat mass (left) 0.5 2.0 4.5 -1.0 0.6 -1.5 -2.1
Arm predicted mass (left) 0.4 2.2 5.6 0.3 1.8 -0.2 -2.4