Hub : Genes

CRTAC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0570 0.0230 5.7e-03 0.035 0.020 0.049 0.033 0.054 3.4e-05 1.5e-03 1.1e-06 6.7e-05 3.6e-07
2 GTEx Heart Atrial Appendage 0.3900 0.0880 1.7e-03 0.130 NA 0.147 NA 0.194 1.9e-06 NA 4.1e-07 NA 4.2e-09
3 GTEx Heart Left Ventricle 0.4197 0.0614 2.6e-08 0.357 NA 0.319 NA 0.339 6.4e-20 NA 1.6e-17 NA 9.4e-19
4 GTEx Nerve Tibial 0.1429 0.0575 5.1e-03 0.069 NA 0.043 NA 0.056 1.3e-05 NA 5.1e-04 NA 8.1e-05
5 ROSMAP Brain Pre-frontal Cortex 0.0877 0.0290 2.3e-04 0.059 0.033 0.040 0.038 0.051 4.8e-08 4.0e-05 5.7e-06 9.3e-06 3.3e-07
6 TCGA Breast Invasive Carcinoma 0.0531 0.0180 2.2e-05 0.045 0.014 0.039 NA 0.043 1.3e-09 4.9e-04 1.4e-08 NA 3.0e-09
7 TCGA Kidney Renal Clear Cell Carcinoma 0.1092 0.0364 7.1e-05 0.075 0.046 0.062 NA 0.061 8.7e-09 5.8e-06 1.8e-07 NA 1.9e-07
8 TCGA Liver Hepatocellular Carcinoma 0.1200 0.0490 5.3e-03 0.083 0.004 0.032 NA 0.063 9.9e-05 1.9e-01 1.2e-02 NA 6.7e-04
9 TCGA Rectum Adenocarcinoma 0.2930 0.1070 7.0e-03 0.037 0.056 0.110 NA 0.047 4.8e-02 1.9e-02 1.6e-03 NA 3.0e-02
10 TCGA Stomach Adenocarcinoma 0.1480 0.0470 8.7e-06 0.143 0.072 0.106 NA 0.127 1.7e-10 7.1e-06 4.2e-08 NA 2.0e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.0 1.6 2.9 1.3 -0.7 -0.1 -1.6 1.0 -1.7 -1.0 -1.7 -1.3 -1.5
Bipolar Disorder or Schizophrenia 0.3 0.8 2.6 0.4 -0.3 0.0 -1.2 0.1 -1.2 -0.6 -1.0 -1.6 -0.9
Depressed Affect (Nagel 2018) 0.3 0.6 1.2 -0.2 1.0 0.7 0.8 0.6 0.9 1.1 1.0 -0.2 0.6
Depression (Nagel 2018) 0.3 0.4 1.0 0.1 0.9 0.6 0.6 -0.1 0.6 0.6 1.0 0.6 0.8
Intelligence (Savage-Jansen 2018) 0.6 2.0 10.7 3.3 -0.7 -0.4 -0.6 2.6 -0.7 -0.3 -0.8 0.3 -0.6
Neuroticism (Nagel 2018) 1.1 2.5 3.9 1.3 1.3 0.4 1.9 1.6 1.9 1.8 2.0 0.8 1.9
Schizophrenia (2018) 0.1 0.2 1.1 -0.5 0.1 0.1 -0.2 -0.7 -0.2 -0.1 0.1 -1.1 -0.0
Schizophrenia vs Biploar Disorder 1.1 1.4 3.9 -2.0 -0.4 -1.2 1.2 -1.2 1.2 0.9 1.2 0.8 1.1
Worry (Nagel 2018) 0.4 0.8 2.8 1.7 -0.3 -0.8 0.6 1.4 0.7 0.7 0.8 -0.5 0.6
Alzheimer’s Disease (in mother) 0.8 0.9 1.9 -0.2 -1.4 -1.2 -1.0 -0.9 -0.9 -0.8 -1.2 0.4 -0.9
Alzheimer’s Disease (in father) 2.6 2.8 6.9 0.6 -2.1 -1.4 -1.9 1.0 -1.8 -1.4 -2.6 -0.5 -2.0
Alzheimer’s Disease (including proxy) 0.6 0.8 3.0 -0.2 -1.1 -0.7 -0.9 -0.2 -0.9 -0.9 -1.7 0.5 -0.8
Crohns Disease (2017) 0.5 1.0 5.0 -1.4 -1.1 -1.4 -0.0 -0.3 -0.0 0.4 0.2 2.2 0.4
Irritable Bowel Disease (IBD) 0.3 0.6 2.0 0.0 -1.4 -1.4 -0.5 0.9 -0.4 -0.0 -0.3 1.0 -0.3
Ulcerative Colitis (UC) 0.5 0.9 1.7 0.8 -1.2 -0.6 -0.9 1.3 -0.8 -0.7 -1.0 -0.7 -1.2
Major Depression (MDD) 1.1 1.3 5.2 2.1 -0.8 -1.2 0.3 2.3 0.5 0.9 0.4 0.6 0.3
Reaction Time 0.9 1.8 3.6 -1.6 -1.3 -0.8 -1.1 -1.9 -1.0 -1.4 -1.4 -1.2 -1.3
Verbal and Numeric Reasoning (VNR) 0.3 0.6 2.5 1.6 -0.4 -0.8 0.2 1.2 0.0 0.5 0.3 1.0 0.3
Breast Cancer 0.2 0.5 0.8 0.5 0.9 0.8 0.6 0.6 0.7 0.7 0.9 0.3 0.6
Ovarian Cancer 0.7 0.9 1.6 -0.9 -0.6 0.0 -1.2 -0.1 -1.2 -1.1 -1.1 -1.3 -1.2
Prostate Cancer 0.3 0.4 1.3 1.2 -0.6 -0.5 -0.0 0.4 0.2 0.4 -0.1 -1.0 -0.5
Age at First Birth 0.5 0.7 2.0 0.3 1.4 1.4 0.8 -0.9 0.7 0.1 0.4 0.3 0.8
Bipolar Disorder (2011) 1.9 1.8 7.0 2.7 -0.8 -0.3 -0.9 2.6 -0.9 -0.6 -0.9 0.0 -0.8
Body Mass Index (BMI) (2010) 0.6 0.8 3.5 -1.9 -0.9 -0.7 -0.8 -1.2 -0.8 -0.1 -0.2 -0.4 -0.7
Coronary Artery Disease (CAD) 0.5 0.6 1.7 0.2 -1.1 -1.3 -0.4 0.7 -0.4 -0.1 -1.0 0.7 -0.4
Crohns Disease (2012) 0.4 0.7 3.9 -0.2 -0.4 -0.7 0.1 1.3 0.1 0.3 0.0 2.0 0.3
Mean Putamen Volume 0.7 0.8 3.3 -0.6 -1.2 -1.8 0.4 0.2 0.3 -0.0 0.6 1.3 0.7
Fasting Glucose 0.2 0.2 0.7 0.1 -0.8 -0.6 -0.5 0.0 -0.6 -0.5 -0.5 0.0 -0.5
HbA1C 0.4 0.4 1.3 0.9 -0.8 -1.1 0.4 1.0 0.4 0.5 0.1 -0.0 0.3
HDL Cholesterol 0.2 0.3 1.6 0.8 -0.4 -0.3 -0.4 1.2 -0.5 0.0 0.1 -0.2 -0.2
LDL Cholesterol 0.8 1.2 3.0 -0.3 0.6 0.0 1.5 -0.2 1.5 1.2 0.9 1.7 1.5
Lupus 2.0 3.0 7.0 2.6 -1.4 -2.3 1.1 1.9 1.2 1.9 1.1 1.7 1.0
Neuroticism (2016) 0.3 0.5 1.8 1.1 -0.7 -0.6 -0.5 1.3 -0.5 -0.2 0.2 -0.3 -0.4
Primary Biliary Cirrhosis 0.0 0.1 0.1 -0.3 -0.2 -0.0 -0.3 0.0 -0.3 -0.3 -0.0 0.1 -0.3
Rheumatoid Arthritis 0.2 0.3 1.0 -0.2 -0.8 -0.5 -0.5 1.0 -0.6 -0.7 -0.4 -0.2 -0.6
Schizophrenia (2014) 0.1 0.3 0.9 -0.4 -0.3 -0.9 0.6 -0.4 0.6 0.7 0.3 0.3 0.8
Triglycerides 1.8 2.9 6.3 -0.8 -0.1 -1.3 1.9 -0.2 2.0 2.3 2.0 2.5 2.0
Type 2 Diabetes (T2D) (2012) 3.4 3.9 6.8 0.0 2.6 2.3 2.2 0.7 2.2 2.0 1.7 2.3 2.2
Ulcerative Colitis 0.2 0.2 0.6 0.4 -0.0 -0.1 0.4 0.6 0.5 0.6 0.4 0.8 0.2
Blood Eosinophil Count 0.5 3.6 7.4 -2.7 -1.0 -0.2 -1.6 -2.7 -1.7 -2.7 -2.2 -0.9 -1.5
Blood Platelet Count 0.2 2.8 8.8 1.2 -3.0 -2.7 -1.4 1.6 -1.3 -0.9 -0.7 -0.9 -1.4
Blood Red Count 0.0 0.4 2.1 -1.4 0.1 -0.0 -0.3 -0.9 -0.3 -0.4 -0.5 0.5 -0.1
Blood White Count 0.6 4.3 6.2 -2.5 -1.4 -0.5 -2.4 -2.4 -2.4 -2.4 -2.1 -1.6 -2.2
Heel T-Score 0.1 0.5 2.9 1.7 -0.0 0.2 0.2 0.9 0.3 -0.3 -0.5 -0.8 -0.1
BMI 1.8 10.2 67.9 -8.2 0.3 0.4 -0.2 -5.5 -0.2 -1.1 -1.2 0.1 -0.3
Height 0.2 3.6 10.4 3.2 -0.3 0.6 -1.9 2.9 -2.0 -1.0 -1.8 -0.6 -2.0
Waist Hip Ratio (WHR) 0.4 1.6 3.4 1.1 -1.5 -1.0 -1.8 0.4 -1.8 -0.8 -0.9 0.9 -1.5
Systolic Blood Pressure 0.4 1.8 4.0 -0.3 0.9 -0.1 1.6 -0.0 1.6 2.0 1.9 1.6 1.5
Smoking Status 1.0 2.5 9.9 -3.1 -0.2 0.7 -1.4 -2.0 -1.3 -1.5 -1.4 -1.1 -1.2
Allergy or Eczema 0.1 0.3 0.6 -0.0 -0.7 -0.4 -0.7 -0.0 -0.7 -0.7 -0.8 -0.4 -0.6
Cardiovascular Disease 0.4 1.5 7.6 -2.8 0.4 -0.2 0.8 -2.0 0.6 0.2 0.9 0.3 1.0
Hypothyroidism (self reported) 0.1 0.3 1.2 0.6 0.1 0.0 0.3 1.1 0.3 -0.0 0.7 -0.2 0.5
Respiratory disease 0.3 0.6 1.3 0.5 -0.4 -1.1 0.8 1.1 0.8 0.8 0.6 -0.2 0.7
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.6 0.1 0.1 -0.3 0.4 0.1 0.3 0.1 0.3 0.2 0.7
Lung FEV1/FVC ratio 0.1 0.7 3.2 -0.0 -1.2 -1.8 0.2 0.7 0.3 0.8 0.3 0.8 0.1
Lung FVC 0.1 0.5 2.2 1.5 0.0 -0.6 1.0 -0.1 0.8 0.2 0.5 -0.2 1.0
Neuroticism 0.6 1.5 2.8 0.9 0.9 0.2 1.6 1.5 1.5 1.0 1.7 -0.3 1.6
Chronotype (morning person) 0.1 0.2 1.2 -0.6 -0.1 -0.1 -0.1 -1.1 -0.1 -0.3 -0.5 0.3 -0.0
Hair Pigment 0.0 0.5 1.8 -0.8 0.5 0.4 0.7 -1.4 0.9 0.7 0.5 0.1 0.4
Tanning 0.2 1.9 5.3 2.0 -0.7 -0.1 -1.1 2.3 -1.2 -0.6 -0.7 -2.0 -1.2
Hand grip strength (left) 1.0 2.7 7.1 2.7 0.3 -0.7 1.4 1.4 1.3 1.5 1.5 2.5 1.6
Number of treatments/medications taken 0.7 1.3 4.1 -2.0 -0.2 0.2 -0.9 -1.7 -1.0 -1.6 -0.8 -0.5 -0.5
Average weekly spirits intake 1.1 1.3 2.6 -1.4 -0.5 -1.3 1.0 -0.6 1.0 1.6 1.4 1.3 1.0
Sensitivity / hurt feelings 2.3 4.0 6.9 1.3 1.1 -0.2 2.6 1.8 2.6 2.4 2.6 1.0 2.5
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.5 -0.1 0.7 0.6 0.4 -0.1 0.5 0.7 0.4 0.3 0.3
Hearing difficulty/problems: Yes 0.7 1.1 3.2 -1.7 1.5 1.8 0.3 -1.3 0.4 -0.2 0.2 -0.3 0.0
Relative age of first facial hair 0.3 0.5 2.1 -0.7 1.2 1.5 0.0 -0.9 0.0 -0.1 -0.1 0.5 0.2
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 5.0 -2.0 0.1 0.8 -1.0 -2.2 -1.0 -0.8 -1.0 -0.1 -1.1
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.8 -0.3 1.0 0.9 0.8 0.7 0.8 0.4 0.0 1.3 0.7
Ever had hysterectomy (womb removed) 2.1 2.3 4.1 -2.0 0.4 1.6 -1.6 -1.1 -1.6 -1.9 -1.2 -1.6 -1.6
Systolic blood pressure, automated reading 0.4 1.1 4.2 -2.0 0.8 0.2 1.2 -1.2 1.2 0.7 0.7 0.5 0.9
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 2.1 1.1 -0.7 -1.1 0.3 1.5 0.3 -0.1 -0.3 0.4 0.4
Angina 0.5 0.7 1.3 -0.7 0.8 0.2 1.0 -0.2 0.9 1.2 1.1 0.7 1.0
Medication for hormone replacement therapy 0.2 0.3 0.8 -0.8 0.4 0.7 0.1 -0.6 0.3 0.2 -0.1 -0.9 -0.3
Vitamin and mineral supplements 0.4 0.6 1.7 1.0 0.8 0.6 0.6 1.3 0.5 0.2 0.1 0.8 0.7
Supplements: Zinc 0.6 0.6 1.2 -0.3 1.1 1.1 0.5 -1.1 0.5 0.4 1.1 -0.9 0.5
Medication: Co-codamol 0.9 1.0 2.4 -0.2 1.1 0.7 1.1 -0.4 1.1 1.2 1.5 0.6 1.1
Medication: Metformin 0.3 0.4 1.2 -0.9 -0.4 -0.8 0.1 -0.8 0.0 0.2 -0.1 1.1 0.5
Diabetes (father) 1.5 1.8 7.6 -0.8 -0.8 -0.0 -1.2 -1.0 -1.1 -1.4 -1.1 -2.8 -1.5
Diabetes (mother) 0.2 0.3 0.6 -0.6 -0.2 -0.5 0.7 -0.6 0.8 0.3 0.4 -0.1 0.6
Severe depression (siblings) 0.4 0.5 1.1 -0.3 1.1 1.0 0.5 -0.5 0.6 0.7 0.9 -0.2 0.5
Pack years adult smoking proportion 1.1 1.6 6.9 -2.4 0.6 1.0 -0.5 -2.6 -0.5 -1.1 -0.9 -0.1 -0.4
Impedance of leg (right) 0.3 1.2 10.5 3.2 -0.4 -0.0 -0.5 0.9 -0.3 0.4 0.2 -0.4 -0.5
Leg fat-free mass (left) 0.3 1.8 12.1 -3.5 0.5 0.6 -0.4 -1.5 -0.4 -1.0 -1.2 0.4 -0.5
Trunk fat percentage 1.4 5.5 33.2 -5.8 0.2 0.7 -0.2 -4.2 -0.1 -1.4 -1.2 0.0 -0.4
Hand grip strength (right) 0.4 1.0 4.0 1.8 0.6 0.1 0.7 0.3 0.6 0.6 0.5 2.0 0.8
Townsend deprivation index at recruitment 1.5 2.0 3.8 0.2 -2.0 -1.2 -1.7 0.3 -1.6 -1.6 -1.8 -0.8 -1.7
Current tobacco smoking 0.6 0.9 2.5 -1.6 -0.0 0.4 -0.8 -0.8 -0.8 -1.1 -1.1 -1.2 -0.7
Average weekly fortified wine intake 0.2 0.2 1.3 0.2 -0.5 -0.1 -0.1 0.3 0.0 -0.3 -1.1 -0.2 -0.5
Maternal smoking around birth 1.5 2.1 4.6 -0.9 1.1 0.1 1.9 -0.8 1.9 1.1 1.3 2.1 2.0
Fed-up feelings 0.2 0.3 1.1 -0.3 -0.2 -0.7 0.5 0.3 0.6 1.1 0.6 0.3 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.3 -0.5 0.3 0.5 -0.2 -0.6 -0.2 0.3 0.3 0.5 -0.1
Relative age voice broke 0.3 0.5 1.5 1.2 1.0 1.1 0.2 0.8 0.2 -0.1 -0.2 0.5 0.3
Taking other prescription medications 0.1 0.2 0.4 -0.3 -0.2 -0.6 0.6 0.3 0.5 0.0 0.2 -0.0 0.7
Age when periods started (menarche) 1.4 3.4 14.7 3.6 -1.0 -0.8 -1.0 3.8 -1.0 -0.7 -0.6 -1.0 -0.9
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 -0.1 0.2 0.6 -0.1 -0.2 0.0 0.1 -0.1 0.5 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.1 0.9 0.8 0.5 1.0 0.9 1.1 1.0 0.2 0.6 0.7
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.0 -0.1 0.0 -0.4 0.8 -0.2 0.8 0.7 1.0 -0.1 0.7
Qualifications: CSEs or equivalent 1.1 1.5 3.0 -1.7 1.6 1.1 1.4 -1.3 1.5 0.6 1.0 0.2 1.0
Serious illness, injury or assault to yourself 0.5 0.6 1.6 -0.0 -0.8 -0.8 -1.0 0.5 -1.1 -0.5 -0.6 1.3 -0.6
High blood pressure 0.5 1.3 6.4 -2.5 0.7 0.2 0.7 -2.1 0.5 -0.2 0.7 -0.1 0.7
Hayfever, allergic rhinitis or eczema 0.2 0.3 1.4 0.6 -1.0 -1.2 -0.1 0.5 -0.1 0.1 -0.4 0.1 -0.2
Multivitamins +/- minerals 0.1 0.2 0.8 -0.8 0.0 0.3 -0.2 -0.9 -0.1 -0.1 0.1 -0.3 -0.2
Stomach or abdominal pain in last month 1.1 1.4 2.8 -0.2 1.3 0.7 1.6 0.0 1.7 1.4 1.4 0.7 1.5
Supplements: Glucosamine 1.9 2.5 4.3 0.2 -2.1 -1.4 -2.0 0.1 -2.0 -1.7 -1.1 -1.7 -1.9
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 -0.3 0.2 0.5 -0.2 0.5 -0.3 -0.4 -0.0 0.2 -0.0
Medication: Atenolol 0.5 0.6 1.7 0.2 -1.3 -1.0 -0.8 0.9 -0.8 -0.7 -0.6 0.6 -0.6
Medication: Levothyroxine sodium 0.0 0.1 0.2 0.0 0.1 0.1 0.3 -0.2 0.3 -0.3 0.3 0.3 0.4
Sitting height 0.6 3.9 11.9 1.9 -1.2 -0.4 -2.2 3.5 -2.1 -1.0 -2.5 -0.8 -2.3
Chronic bronchitis/emphysema (father) 0.1 0.1 0.5 -0.3 0.4 0.3 0.2 -0.7 0.1 -0.0 0.2 0.1 0.4
High blood pressure (mother) 2.6 3.7 8.0 -2.2 2.8 2.2 2.1 -1.3 2.1 1.5 1.3 1.0 2.0
Body mass index (BMI) 1.7 7.4 50.3 -7.1 0.8 0.4 0.9 -4.4 0.9 -0.4 -0.0 0.9 1.0
Impedance of leg (left) 0.4 1.8 15.5 3.9 -0.4 -0.1 -0.4 1.3 -0.2 0.4 0.4 -0.2 -0.4
Leg predicted mass (left) 0.3 1.8 11.9 -3.5 0.4 0.7 -0.4 -1.4 -0.5 -1.0 -1.3 0.3 -0.6
Trunk fat mass 1.2 5.2 32.6 -5.7 0.3 0.8 -0.3 -3.7 -0.2 -1.4 -1.4 0.3 -0.4
Waist circumference 1.2 4.5 28.2 -5.3 0.3 0.6 -0.5 -3.5 -0.5 -1.4 -1.2 0.7 -0.4
Number of incorrect matches in round 0.6 1.1 5.0 -1.9 -0.7 -0.6 -0.6 -2.2 -0.5 -0.2 -0.2 0.1 -0.7
Past tobacco smoking 0.2 0.4 2.2 1.5 -0.5 -0.7 0.2 0.7 0.2 -0.2 -0.3 0.1 -0.0
Alcohol usually taken with meals 0.4 0.7 1.8 -0.0 -0.2 0.6 -1.1 -0.2 -1.0 -0.8 -1.4 -0.8 -1.0
Nervous feelings 0.9 1.7 7.3 2.7 -1.2 -1.4 -0.0 2.3 -0.0 0.1 -0.2 -0.5 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.7 -0.5 -1.3 -1.2 -0.9 -0.2 -0.8 -0.4 -0.6 -0.0 -0.7
Hearing difficulty/problems with background noise 0.1 0.2 0.6 0.4 0.2 -0.1 0.7 0.3 0.8 0.2 0.4 0.7 0.4
Hair/balding pattern: Pattern 2 0.9 1.1 3.7 0.8 0.2 0.9 -1.1 0.6 -1.1 -1.9 -1.1 -1.0 -0.9
Had menopause 0.3 0.4 2.1 -1.5 0.1 0.3 -0.4 -0.3 -0.4 -0.9 -0.5 0.3 -0.1
Had other major operations 0.2 0.2 1.4 -1.2 -0.2 -0.1 -0.2 -0.4 -0.1 0.1 0.4 -0.6 -0.1
Forced vital capacity (FVC) 0.3 1.1 7.6 2.8 -0.1 -0.5 0.6 1.4 0.5 0.5 0.3 0.2 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.3 0.8 1.1 1.2 0.5 0.6 0.5 0.4 -0.1 -0.2 0.2
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 6.1 0.5 1.2 0.2 1.9 0.7 1.7 1.6 2.5 0.4 1.9
Qualifications: None of the above 0.5 1.1 2.2 -0.5 0.0 -0.9 1.4 0.4 1.4 1.0 1.2 1.1 1.5
Financial difficulties in last 2 years 0.5 0.7 2.7 -1.2 0.0 0.1 -0.5 -0.8 -0.4 -0.7 -1.6 -0.8 -0.6
Mouth/teeth dental problems 1.1 1.7 4.2 1.7 -1.3 -0.9 -1.1 2.0 -1.1 -0.9 -1.5 -0.9 -0.9
Heart attack 0.5 0.7 2.6 -0.8 -1.6 -1.6 -0.4 0.1 -0.3 -0.3 -0.6 0.2 -0.5
Allergy 0.5 1.1 2.9 -1.0 1.6 1.7 0.7 -1.2 0.7 0.3 0.6 0.8 0.7
Pain all over the body in last month 1.1 1.2 2.9 -1.7 0.8 -0.1 1.0 -1.4 0.7 1.0 1.3 0.9 1.3
Diabetes (self-reported) 0.1 0.1 0.3 -0.2 0.2 0.4 -0.5 -0.1 -0.6 -0.5 -0.5 0.1 -0.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.2 0.9 -0.7 -0.4 -0.6 0.0 -0.5 -0.5 -1.1 -0.8 -0.9
Medication: Ramipril 1.4 1.8 3.4 -1.1 1.9 1.5 1.6 -1.3 1.6 0.6 1.2 0.4 1.6
Medication: Simvastatin 0.3 0.4 1.2 -0.6 0.6 0.1 1.0 -0.0 0.9 0.4 0.7 -0.2 1.1
Fluid intelligence score 0.8 1.7 7.7 2.8 -1.0 -1.0 -0.6 2.5 -0.6 0.3 -0.2 0.3 -0.6
Illnesses of siblings 1.6 2.3 10.3 3.2 1.0 1.8 -0.5 2.6 -0.5 -0.5 -0.7 0.3 -0.5
Neuroticism score 0.5 1.0 2.3 0.6 0.3 -0.4 1.2 0.9 1.2 1.4 1.5 0.0 1.1
Weight 0.7 3.6 25.6 -5.1 0.4 0.5 0.0 -2.6 0.0 -0.9 -1.0 0.8 -0.0
Impedance of arm (right) 0.8 3.6 14.7 3.8 -1.6 -0.4 -1.6 1.7 -1.5 -1.3 -1.5 -1.9 -1.8
Arm fat percentage (right) 1.6 6.2 41.6 -6.5 0.2 0.2 0.5 -4.3 0.5 -0.9 -0.7 0.3 0.4
Trunk fat-free mass 0.1 0.5 2.2 -1.5 0.2 0.1 -0.4 0.3 -0.5 -0.5 -1.0 1.0 -0.4
Hip circumference 1.2 5.4 34.0 -5.8 0.9 1.3 -0.4 -3.4 -0.3 -1.5 -1.6 -0.2 -0.5
Time employed in main current job 2.0 2.3 5.4 -0.8 2.3 2.1 1.5 -1.7 1.4 0.5 1.0 1.3 1.6
Alcohol intake versus 10 years previously 0.8 1.2 4.7 -0.6 0.7 -0.1 1.3 -0.4 1.2 1.1 0.4 2.2 1.3
Father’s age at death 0.8 1.0 1.7 -0.1 0.5 1.2 -1.2 0.4 -1.2 -1.1 -1.3 -1.1 -1.1
Worrier / anxious feelings 0.4 0.8 2.1 1.4 -0.9 -0.8 -0.4 1.4 -0.5 -0.5 -0.4 -1.1 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.2 -1.4 0.0 -0.7 1.1 -1.5 1.1 0.7 1.0 0.9 1.2
Falls in the last year 0.7 0.9 2.3 -0.3 -0.5 -0.1 -1.3 -0.6 -1.3 -0.4 -0.6 -1.5 -1.5
Hair/balding pattern: Pattern 3 1.1 1.6 3.2 -0.1 0.9 0.1 1.7 -0.2 1.8 1.8 1.3 1.3 1.6
Number of live births 0.1 0.2 0.3 -0.0 -0.4 -0.1 -0.5 -0.2 -0.5 -0.4 -0.5 -0.5 -0.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 5.1 2.3 -0.0 -0.8 1.0 1.3 1.0 1.1 0.9 0.9 0.9
Pulse rate 0.3 0.5 1.5 -0.3 -1.2 -1.0 -0.6 -0.5 -0.6 -0.6 -0.6 0.3 -0.4
Happiness 0.8 1.0 4.6 -2.1 0.4 0.9 -0.3 -1.8 -0.1 -0.1 0.2 -0.8 -0.5
Noisy workplace 3.7 4.6 7.9 -2.6 2.1 1.4 2.3 -2.8 2.4 2.0 2.2 0.9 2.0
Qualifications: A levels/AS levels or equivalent 0.5 1.0 2.4 1.0 -0.3 0.6 -1.0 0.4 -0.9 -0.8 -1.6 -1.2 -1.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.9 -0.5 1.0 0.8 0.5 -0.6 0.4 0.4 0.6 -0.8 0.4
Mouth/teeth dental problems: Dentures 0.2 0.3 1.8 -1.4 -0.0 -0.3 0.3 -0.5 0.3 0.4 0.2 0.4 0.3
Asthma 0.6 1.1 4.5 1.3 -1.5 -2.1 -0.1 1.6 -0.1 0.0 -0.7 0.2 -0.0
Medication: Ibuprofen (e.g. Nurofen) 2.5 3.2 4.3 -1.9 0.4 1.8 -2.1 -1.9 -2.1 -1.9 -1.7 -1.5 -2.0
Medication: Cholesterol lowering 0.5 0.8 1.6 -1.3 0.3 -0.4 0.9 -0.9 0.8 0.8 1.0 1.0 1.1
Depression (self-reported) 1.9 2.3 4.4 0.9 0.5 -0.5 2.1 1.4 2.0 1.5 1.9 1.2 2.0
Medication: Lansoprazole 0.9 1.0 2.2 -0.9 0.2 -0.5 1.5 -0.6 1.5 0.8 0.2 1.2 1.4
Prospective memory result 0.3 0.4 1.0 -0.6 0.5 0.2 0.8 -0.8 1.0 0.5 0.1 0.4 0.6
Lung cancer (father) 2.7 3.1 6.2 -0.3 0.9 -0.2 2.4 -0.3 2.5 2.1 2.4 1.4 2.5
Illnesses of mother 2.1 2.6 4.3 1.5 -1.9 -1.2 -2.0 1.9 -2.1 -1.3 -1.1 -1.2 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.8 1.3 0.1 -0.8 1.2 0.4 1.3 1.2 0.9 0.4 1.0
Pulse wave Arterial Stiffness index 0.7 0.9 3.2 0.2 -0.9 -0.4 -0.8 0.7 -0.7 -0.7 -1.1 -1.8 -1.0
Impedance of arm (left) 0.9 4.4 9.4 3.1 -1.9 -0.5 -2.3 0.8 -2.1 -1.9 -2.1 -2.2 -2.6
Arm fat mass (right) 1.3 5.5 38.9 -6.2 0.4 0.2 0.4 -3.7 0.4 -0.9 -0.8 0.5 0.4
Trunk predicted mass 0.1 0.5 2.5 -1.6 0.4 0.3 -0.2 0.2 -0.3 -0.3 -0.8 1.1 -0.2
Standing height 0.4 3.9 11.8 3.4 -0.6 0.3 -1.9 3.1 -1.9 -1.2 -2.1 -0.2 -2.1
Length of working week for main job 0.5 0.5 1.4 -0.9 -0.8 -0.4 -0.7 -1.2 -0.5 -0.3 -0.8 0.4 -0.9
Exposure to tobacco smoke at home 0.2 0.2 0.8 -0.8 -0.0 -0.3 0.1 -0.9 -0.0 -0.2 0.6 0.4 0.5
Breastfed as a baby 1.2 1.4 3.6 -0.3 -0.3 0.5 -1.5 0.1 -1.6 -1.9 -0.8 -1.7 -1.3
Tense / ‘highly strung’ 0.2 0.4 1.3 -1.1 0.3 -0.3 0.6 -0.1 0.6 0.8 0.8 0.5 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.5 -0.3 -0.1 0.1 -0.4 0.7 -0.5 -0.5 -0.1 -0.6 -0.4
Hair/balding pattern: Pattern 4 0.1 0.3 2.1 -1.5 -0.0 -0.1 -0.1 -0.7 -0.1 -0.3 0.3 -0.7 -0.0
Birth weight of first child 0.3 0.6 2.2 -0.1 1.1 1.5 -0.6 -0.8 -0.7 -0.8 -0.2 -0.6 -0.6
Peak expiratory flow (PEF) 0.6 1.3 5.0 1.2 0.2 -0.4 0.8 1.6 0.8 1.2 0.7 2.2 1.0
Pulse wave reflection index 0.2 0.3 2.0 -0.5 -0.1 -0.1 0.1 0.3 0.3 0.5 0.1 -1.4 -0.4
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.2 0.1 0.2 -0.5 0.7 1.0 0.7 1.1 0.7 1.1 0.8
Loud music exposure frequency 1.6 1.8 4.5 -1.8 2.1 1.9 1.0 -1.0 1.0 0.3 1.2 0.7 1.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.8 0.9 0.7 0.5 0.9 0.0 0.9 0.7 0.5 0.8 0.8
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 7.5 -2.1 0.7 1.1 -0.2 -2.7 -0.2 -0.3 0.1 0.1 -0.2
Blood clot in the leg (DVT) 0.5 0.7 1.4 0.3 -0.0 0.8 -1.2 0.1 -1.2 -0.7 -0.5 -1.0 -1.1
Medication: Paracetamol 0.7 1.1 2.5 -1.6 -0.6 0.0 -1.2 -1.5 -1.1 -0.9 -0.9 0.1 -1.3
Headache pain in last month 2.2 3.8 6.7 -1.5 2.6 2.0 2.1 -1.1 2.2 2.1 2.3 1.2 1.9
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.3 1.1 -0.2 0.5 -0.8 0.9 -0.6 -0.5 -0.6 -1.1 -1.0
Glaucoma (self-reported) 0.9 1.0 4.1 2.0 -0.5 -1.2 0.6 1.0 0.6 1.2 0.8 0.6 0.6
Gout (self-reported) 0.6 0.8 4.2 -0.2 1.4 2.0 0.1 -0.3 0.3 -0.5 -0.4 -1.2 -0.2
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 3.3 0.9 1.8 1.8 1.1 0.4 1.1 0.4 1.3 0.4 1.2
Medication: Amlodipine 0.9 1.3 3.4 -1.8 -0.9 -1.7 0.5 -1.2 0.5 0.9 0.3 1.5 0.6
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.1 0.6 0.9 0.5 0.9 0.3 0.8 0.8 0.3 1.0 1.1
Birth weight 0.2 0.4 1.4 0.2 -1.1 -1.2 -0.3 0.9 -0.3 0.3 -0.0 0.3 -0.2
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.8 -1.0 -0.4 -0.8 0.6 -1.3 0.6 0.5 0.9 0.9 0.7
High blood pressure (siblings) 1.2 1.7 11.2 -3.4 -0.5 -0.8 -0.0 -2.2 -0.0 -0.1 0.2 -0.7 0.1
Forced vital capacity (FVC), Best measure 0.2 0.6 2.6 1.6 0.5 -0.1 0.9 0.4 0.9 0.8 0.4 0.2 0.7
Body fat percentage 1.6 6.3 39.6 -6.3 0.3 0.7 -0.0 -4.5 0.1 -1.2 -1.0 0.2 -0.1
Leg fat percentage (right) 1.8 6.5 41.0 -6.4 0.5 0.3 0.7 -4.5 0.8 -0.4 -0.1 1.2 0.7
Arm fat-free mass (right) 0.2 1.1 8.2 -2.9 0.6 0.4 -0.1 -0.7 -0.1 -0.4 -0.6 1.1 -0.1
Exposure to tobacco smoke outside home 1.1 1.4 3.8 -0.9 1.0 0.1 1.4 -1.1 1.3 1.2 2.0 0.5 1.5
Comparative body size at age 10 0.4 1.0 2.0 -0.9 -0.1 0.5 -1.3 -0.1 -1.3 -1.4 -1.2 -1.2 -1.0
Number of full brothers 0.9 1.2 3.8 1.7 0.5 0.2 0.7 2.0 0.8 1.2 1.1 -0.6 0.5
Worry too long after embarrassment 0.8 1.4 2.9 0.1 0.9 0.2 1.6 0.0 1.5 1.1 1.7 1.1 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.9 0.8 0.3 -0.4 1.2 0.9 1.1 0.8 1.0 0.8 1.4
Wheeze or whistling in the chest in last year 0.2 0.4 1.5 -1.2 -0.2 -0.5 0.1 -1.2 0.1 -0.0 -0.3 -0.5 -0.1
Number of children fathered 0.2 0.3 1.2 -1.1 0.4 0.2 0.1 -0.7 0.2 0.4 0.3 0.5 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.7 -0.4 0.3 0.8 -0.7 -0.8 -0.7 -0.6 -0.5 -0.2 -0.5
Age at first live birth 0.6 1.1 1.9 0.6 -0.2 0.7 -1.3 -0.5 -1.4 -1.4 -1.3 -0.9 -1.3
Pulse wave peak to peak time 0.6 0.7 2.7 0.2 0.9 0.5 0.7 -0.5 0.5 0.6 0.9 1.6 0.9
Health satisfaction 1.4 1.8 7.3 -2.7 0.5 -0.2 1.2 -2.0 1.2 1.4 0.9 0.1 0.9
Shortness of breath walking on level ground 1.4 1.6 3.5 -1.4 -0.4 -1.6 1.9 -0.5 1.9 1.3 0.8 0.3 1.5
Qualifications: College or University degree 0.8 2.5 5.7 2.4 -0.3 1.0 -1.9 1.6 -1.8 -1.1 -1.3 -1.3 -1.9
Eye problems/disorders: None of the above 1.4 1.6 3.4 1.3 -1.6 -0.8 -1.2 1.8 -1.2 -1.0 -1.4 -0.3 -1.0
Mouth/teeth dental problems: Loose teeth 1.4 1.7 3.0 -0.3 1.6 1.0 1.5 -0.6 1.5 1.5 1.7 1.0 1.3
Emphysema/chronic bronchitis 0.4 0.4 0.9 0.6 -0.9 -0.7 -0.6 -0.0 -0.5 -0.1 -0.8 -0.6 -0.9
Medication for pain relief, constipation, heartburn 0.9 1.5 6.5 2.5 -0.5 -1.0 0.7 2.1 0.8 1.0 0.7 -0.2 0.5
Neck or shoulder pain in last month 0.8 1.2 4.9 -2.2 0.9 1.0 0.1 -2.1 0.0 -0.2 0.6 -0.5 0.1
Medication: Blood pressure 0.3 0.6 0.9 -0.9 0.7 0.2 0.9 -0.8 0.8 0.4 0.7 0.7 1.0
Angina (self-reported) 0.8 1.0 2.1 -0.5 0.7 0.0 1.3 -0.2 1.3 1.5 1.3 0.8 1.2
Migraine (self-reported) 0.5 0.6 2.9 -1.1 1.2 1.7 0.0 -0.4 0.1 0.2 0.3 -0.3 0.0
Medication: Ibuprofen 3.2 3.9 5.8 -2.2 0.4 1.8 -2.4 -2.0 -2.4 -2.0 -1.6 -1.8 -2.2
Medication: Allopurinol 0.5 0.7 1.9 -0.5 0.7 1.4 -0.6 0.0 -0.6 -0.9 -0.7 -1.3 -0.7
Medication: Omeprazole 0.7 0.9 2.0 -1.1 0.3 1.0 -0.9 -1.4 -0.9 -1.1 -0.9 -0.1 -0.7
Medication: Seretide 50 evohaler 0.6 0.7 1.8 -0.1 0.6 -0.1 1.2 -0.4 1.2 1.4 0.8 0.5 1.1
Mean time to correctly identify matches 1.2 2.4 6.8 -2.6 -0.9 -0.5 -1.0 -2.6 -0.9 -1.4 -1.4 -1.4 -1.2
Heart disease (mother) 3.3 4.0 10.3 -0.6 3.2 2.8 2.2 -1.1 2.3 1.7 1.6 1.0 1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 2.2 0.9 -0.2 -0.8 0.9 1.3 1.0 1.4 1.5 0.7 0.7
Whole body fat mass 1.4 5.8 37.9 -6.2 0.4 0.6 0.0 -4.0 0.1 -1.2 -1.1 0.5 -0.1
Leg fat mass (right) 1.8 6.8 43.8 -6.6 1.0 0.8 0.6 -4.5 0.7 -0.6 -0.4 1.2 0.6
Arm predicted mass (right) 0.2 1.2 8.9 -3.0 0.6 0.3 0.1 -0.9 -0.0 -0.2 -0.4 1.2 0.1
Pulse rate, automated reading 0.1 0.4 1.5 -1.2 0.5 0.5 0.2 -1.2 0.1 -0.4 -0.2 0.8 0.5
Alcohol intake frequency. 1.2 2.7 16.7 -4.1 -0.3 -1.2 0.7 -2.0 0.6 0.6 0.8 1.4 1.1
Comparative height size at age 10 0.3 1.7 4.9 0.1 0.0 1.0 -1.7 -0.5 -1.7 -1.5 -2.2 0.4 -1.7
Number of full sisters 1.7 2.1 4.4 -0.9 0.9 -0.2 1.8 -0.8 1.6 1.2 1.7 2.0 2.1
Suffer from ‘nerves’ 0.6 0.9 5.2 2.3 -0.2 -0.5 0.2 1.6 0.1 0.2 0.7 -0.1 0.5
Overall health rating 3.3 7.0 31.8 -5.6 2.0 1.2 1.6 -4.9 1.5 0.5 0.9 1.0 1.7
Chest pain or discomfort 0.8 1.1 2.2 -1.4 1.0 0.2 1.2 -1.5 1.2 1.1 1.1 0.3 1.0
Had major operations 0.4 0.5 1.6 -0.5 -0.9 -0.8 -0.7 -0.0 -0.6 -0.5 -1.3 0.2 -0.7
Age at last live birth 0.7 1.0 2.5 0.2 0.0 0.9 -1.2 -0.7 -1.3 -1.6 -1.1 -0.9 -1.1
Family relationship satisfaction 0.9 1.1 5.4 -2.3 0.3 0.2 0.4 -1.9 0.5 0.9 0.6 -0.2 0.1
Leg pain on walking 0.5 0.6 1.9 -1.4 -0.2 0.3 -0.6 -1.0 -0.5 -0.7 -0.8 -1.0 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.9 -0.9 -0.9 -0.7 -0.5 -0.8 -0.6 -0.7 0.1 -0.2 -0.4
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.8 -0.5 0.2 -0.3 0.9 -0.5 0.8 -0.1 0.4 0.1 0.8
Illness, injury, bereavement, stress in last 2 years 0.0 0.1 0.4 0.6 -0.0 0.2 -0.1 0.3 -0.0 -0.0 -0.2 -0.0 -0.1
Medication: Aspirin 1.2 1.5 8.5 -2.9 0.9 0.6 0.4 -2.1 0.3 0.4 0.5 0.4 0.6
Supplements: Vitamin C 0.5 0.6 1.8 1.3 0.1 0.5 -0.6 0.4 -0.5 -0.2 -0.2 -1.3 -0.9
Knee pain experienced in last month 0.7 1.0 4.8 -2.2 -0.2 -0.7 0.1 -1.1 0.2 1.1 0.8 1.3 0.3
Hypertension (Self-reported) 0.5 1.5 7.3 -2.7 1.0 0.9 0.3 -2.2 0.1 -0.8 0.1 -0.4 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.2 2.7 -0.7 0.6 -0.2 1.3 -1.5 1.2 0.6 1.6 0.5 1.6
Illnesses of father: Heart disease 1.2 1.7 3.9 -1.4 2.0 1.7 1.4 -1.2 1.3 0.3 1.3 -0.7 1.1
Illnesses of siblings: Diabetes 0.8 1.0 2.0 -1.4 -0.4 -1.2 1.0 -1.1 1.1 0.9 1.0 -0.0 0.8
Smoking status: Previous 0.3 0.4 2.7 -1.6 0.4 0.5 -0.0 -1.0 -0.0 0.1 0.2 0.1 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.0 0.9 0.8 0.6 0.4 1.0 0.3 0.3 0.1 0.3 0.5
Whole body fat-free mass 0.2 0.9 5.8 -2.4 0.3 0.3 -0.3 -0.4 -0.4 -0.6 -1.1 0.8 -0.4
Leg fat-free mass (right) 0.2 1.2 8.0 -2.8 0.4 0.5 -0.3 -1.0 -0.4 -0.9 -1.2 0.5 -0.5
Arm fat percentage (left) 1.8 7.2 47.4 -6.9 0.1 0.3 0.1 -4.7 0.2 -1.2 -1.0 0.2 0.0
Average weekly red wine intake 0.4 0.6 1.3 1.0 -0.5 -1.0 0.6 0.8 0.5 0.7 1.1 -0.2 0.6
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.6 -0.8 -0.1 0.0 -0.3 -0.3 -0.3 -0.4 0.1 -0.2 -0.2
Mood swings 0.2 0.3 0.9 -0.6 0.7 0.4 0.8 -0.0 0.9 0.6 0.4 0.1 0.5
Loneliness, isolation 0.4 0.5 1.0 -0.3 1.0 0.8 0.9 -0.4 1.0 0.8 0.6 0.1 0.6
Long-standing illness, disability or infirmity 0.7 1.0 3.1 -1.5 -0.4 -0.0 -1.0 -1.7 -0.9 -1.0 -1.1 -0.0 -0.9
Ever had bowel cancer screening 0.2 0.2 1.0 0.4 -0.3 -0.6 0.3 1.0 0.1 -0.3 0.2 0.1 0.5
Diabetes diagnosed by doctor 0.1 0.2 0.3 -0.5 -0.1 -0.0 -0.4 -0.5 -0.5 -0.5 -0.5 0.2 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 2.6 -0.4 0.7 1.2 -0.2 -0.5 -0.1 -0.7 -0.5 -1.6 -0.3
Friendships satisfaction 1.0 1.2 3.1 -0.1 0.8 0.3 1.2 -0.5 1.4 1.8 1.7 0.6 1.1
Qualifications: nursing, teaching 0.3 0.4 1.2 -0.3 -0.3 0.1 -0.7 -0.7 -0.6 -0.3 -1.1 -0.0 -1.0
Commuting to job workplace: Walk 0.5 0.5 2.2 0.4 1.3 1.5 0.1 0.6 0.2 0.2 0.2 -1.0 0.0
Eye problems/disorders: Cataract 0.7 0.8 3.8 -1.9 0.8 0.5 0.5 -1.4 0.4 0.6 0.6 -0.5 0.4
Mouth/teeth dental problems: Mouth ulcers 1.5 2.4 8.2 -1.0 2.9 2.8 1.1 -1.1 1.1 1.0 0.9 0.6 0.9
Medication for cholesterol 0.9 1.3 6.3 2.5 -0.7 -1.0 -0.1 1.9 -0.0 1.1 0.3 0.8 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.6 0.3 0.5 0.8 -0.1 0.5 -0.1 -0.1 -0.4 -0.4 -0.3
Back pain experienced in last month 2.0 3.0 10.4 -3.2 1.2 0.8 1.1 -3.2 1.2 0.5 0.8 1.4 1.2
Mineral and other dietary supplements 0.3 0.4 1.1 -1.1 0.9 0.9 0.4 -0.4 0.5 0.3 -0.2 1.0 0.4
Breast cancer (self-reported) 0.1 0.2 0.8 -0.2 -0.2 -0.1 -0.3 0.1 -0.3 -0.6 -0.1 0.9 0.1
Asthma (self-reported) 0.6 1.2 4.4 1.5 -1.5 -2.1 -0.1 1.6 -0.1 0.1 -0.6 0.3 -0.0
Osteoporosis (self-reported) 0.1 0.2 0.7 0.5 -0.1 -0.4 0.2 0.8 0.2 0.2 0.1 -0.5 0.4
Osteoarthritis (self-reported) 0.4 0.5 2.1 -1.4 -0.1 0.3 -0.6 -1.1 -0.4 -0.4 -0.7 -0.6 -0.8
Medication: Aspirin 1.9 2.5 11.2 -3.4 1.2 0.6 1.0 -2.3 0.8 0.8 1.3 0.9 1.4
Medication: Gliclazide 1.1 1.2 3.6 -1.9 -1.0 -1.3 -0.2 -1.6 -0.3 -0.3 -1.3 1.3 0.1
Illnesses of father: None of the above (group 1) 1.2 1.4 4.7 0.8 -2.2 -2.1 -0.9 1.0 -0.9 -0.2 -0.8 0.9 -0.7
Smoking status: Current 0.4 0.6 1.5 -1.2 -0.2 0.0 -0.7 -0.5 -0.7 -0.9 -0.9 -1.2 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 7.0 -0.2 0.7 -0.7 2.3 -0.6 2.2 2.0 2.3 2.5 2.6
Whole body water mass 0.1 0.8 5.7 -2.4 0.3 0.2 -0.3 -0.4 -0.3 -0.5 -1.0 0.9 -0.3
Leg predicted mass (right) 0.2 1.2 8.0 -2.8 0.4 0.5 -0.3 -1.0 -0.4 -0.8 -1.2 0.6 -0.4
Arm fat mass (left) 1.4 5.9 41.9 -6.5 0.3 0.3 0.3 -3.9 0.3 -0.9 -0.9 0.5 0.2
Number of self-reported non-cancer illnesses 0.5 0.9 3.2 -1.8 0.4 0.6 -0.3 -1.6 -0.4 -1.3 -0.7 -0.7 -0.2
Average weekly champagne plus white wine intake 0.3 0.4 0.9 -0.1 -0.9 -0.7 -0.8 0.2 -0.7 -0.1 -0.8 -0.4 -0.8
Miserableness 0.5 0.8 2.0 0.9 0.6 0.1 0.9 1.3 0.9 1.4 1.2 0.4 0.6
Guilty feelings 0.4 0.6 1.1 -1.1 1.0 0.8 0.7 -0.7 0.8 0.6 1.0 0.3 0.7
Wears glasses or contact lenses 0.1 0.2 0.7 -0.6 -0.2 -0.3 0.1 0.1 0.2 0.4 0.2 0.8 0.3
Ever taken oral contraceptive pill 0.3 0.3 0.8 0.1 -0.9 -0.9 -0.1 0.9 -0.0 0.3 -0.4 0.5 -0.1
Hearing aid user 1.1 1.3 3.2 0.6 1.8 1.7 1.1 0.7 1.1 0.7 0.7 -0.9 1.1
Mother’s age at death 0.1 0.1 0.6 0.4 -0.5 -0.8 0.2 0.4 0.1 0.0 0.4 0.3 0.1
Financial situation satisfaction 1.0 1.2 2.9 -1.7 0.9 0.2 1.1 -0.9 1.2 1.6 1.1 0.4 0.8
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.8 -0.9 0.3 0.3 0.3 -0.1 0.3 0.2 -0.2 -0.4 -0.0
Commuting to job workplace: Public transport 0.2 0.2 1.0 1.0 0.3 0.6 -0.2 0.3 -0.1 -0.1 0.5 -0.0 -0.0
Eye problems/disorders: Glaucoma 0.4 0.4 1.3 1.0 0.3 -0.3 0.6 -0.3 0.6 1.1 0.6 0.8 0.4
Medication: Blood pressure 0.7 1.4 6.2 -2.5 -0.6 -0.5 -0.4 -1.9 -0.5 -1.6 -0.6 -0.4 -0.1
Pain type(s) experienced in last month: Hip pain 2.2 2.8 17.0 -4.1 0.7 0.8 -0.1 -3.1 -0.0 -0.1 -0.1 -0.7 -0.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.1 -0.4 0.1 0.5 -0.8 -1.1 -0.8 -0.8 -0.6 -1.0 -0.8
High cholesterol (Self-reported) 0.8 1.4 2.8 -1.1 1.6 1.0 1.4 -1.0 1.2 0.5 1.2 0.2 1.7
Medication: Bendroflumethiazide 0.3 0.4 2.0 -1.2 -0.1 -0.1 -0.0 -1.4 -0.1 -0.7 -0.4 0.3 -0.0
Medication: Paracetamol 1.1 1.7 2.7 -1.6 -0.7 0.1 -1.6 -1.5 -1.5 -1.4 -1.3 -0.3 -1.6
Medication: Lisinopril 0.3 0.4 1.4 -1.2 -0.9 -0.9 -0.3 -0.5 -0.4 -0.6 -0.1 -0.3 -0.3
Medication: Atorvastatin 0.4 0.5 2.5 -1.2 0.5 0.6 0.1 -1.6 0.1 -0.5 -0.2 -0.1 0.1
Illnesses of father: High blood pressure 2.0 2.4 4.8 -0.4 2.2 1.9 1.8 -0.3 1.9 1.8 1.9 0.2 1.3
Alcohol drinker status: Never 1.0 1.1 5.7 -1.1 -1.7 -2.4 -0.1 0.6 -0.0 0.9 -0.4 0.6 -0.2
Ever smoked 0.9 1.7 2.6 -1.4 0.1 1.1 -1.6 -0.7 -1.5 -1.4 -1.2 -1.6 -1.4
Basal metabolic rate 0.2 1.3 9.4 -3.1 0.4 0.4 -0.2 -1.0 -0.2 -0.6 -1.0 0.9 -0.3
Leg fat percentage (left) 1.6 5.8 36.7 -6.1 0.6 0.4 0.7 -4.2 0.7 -0.3 -0.0 1.2 0.7
Arm fat-free mass (left) 0.2 1.1 8.4 -2.9 0.6 0.3 0.3 -0.5 0.3 -0.1 -0.5 1.3 0.3
Number of operations (self-reported) 0.7 1.1 2.3 -0.6 -1.5 -1.1 -1.3 -0.1 -1.1 -0.8 -1.3 -0.4 -1.3
Average weekly beer plus cider intake 0.3 0.4 1.5 -1.2 0.3 0.2 0.4 -1.2 0.4 -0.0 0.7 0.2 0.3
Irritability 1.4 2.3 4.2 0.4 0.5 -0.8 2.1 1.3 2.0 1.9 1.6 1.6 1.9
Risk taking 1.0 1.4 6.5 -2.5 0.4 0.7 -0.7 -2.1 -0.9 -0.8 -0.6 -0.3 -0.4
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 0.2 0.4 0.0 0.6 0.0 0.5 -0.1 0.8 0.4 0.8
Fractured/broken bones in last 5 years 0.2 0.2 0.5 -0.4 0.3 0.3 -0.5 0.2 -0.7 -0.7 -0.5 -0.4 -0.1
Age started oral contraceptive pill 2.1 2.6 4.9 0.0 -1.7 -0.7 -2.2 0.4 -2.2 -2.1 -2.2 -0.3 -2.0
Diastolic blood pressure, automated reading 0.3 1.1 2.1 -1.0 1.3 0.7 1.4 -0.6 1.4 0.7 0.9 0.6 1.2
Ever depressed for a whole week 0.2 0.2 0.6 -0.6 0.8 0.6 0.4 -0.2 0.3 0.1 0.7 -0.1 0.4
Unable to work because of sickness or disability 1.2 1.5 3.0 -1.2 -0.3 -1.6 1.4 -0.5 1.3 1.7 0.9 1.1 1.4
Commuting to job workplace: Cycle 1.4 1.6 3.2 1.2 -0.6 0.4 -1.8 1.0 -1.8 -1.2 -1.3 -0.9 -1.8
Myopia 2.2 3.2 8.4 2.7 -2.1 -2.9 -0.2 2.7 -0.3 0.4 -0.3 1.9 0.1
Vascular/heart problems diagnosed by doctor 0.4 1.1 6.7 2.6 -0.0 0.5 -0.5 1.7 -0.4 0.1 -0.6 0.1 -0.5
Cholesterol lowering medication 0.2 0.3 0.7 -0.6 0.7 0.6 0.5 -0.9 0.5 -0.6 -0.4 -0.1 0.6
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.4 -0.1 -0.2 -0.2 -0.1 -0.6 -0.1 -0.5 -0.3 0.6 0.2
Pain experienced in last month 3.4 5.7 14.4 3.8 -2.1 -1.4 -1.8 3.6 -1.9 -1.7 -2.1 -2.4 -1.7
Supplements: Calcium 0.1 0.1 0.2 0.2 0.0 -0.2 0.4 0.1 0.4 0.1 0.2 0.0 0.5
Basal cell carcinoma (self-reported) 4.9 5.8 10.1 -0.1 -0.1 -2.2 3.1 0.3 3.2 2.8 2.5 3.1 3.1
Heart attack/myocardial infarction (self-reported) 0.5 0.7 2.4 -0.8 -1.6 -1.5 -0.5 0.1 -0.4 -0.4 -0.8 0.1 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.0 0.3 0.2 0.9 -1.0 -0.1 -1.0 -0.6 -0.4 -0.8 -1.0
Heart disease (siblings) 0.7 0.9 1.8 -1.0 -0.6 -1.3 0.8 -1.4 0.8 0.7 0.8 1.0 0.7
Alcohol drinker status: Previous 0.9 1.1 5.2 -2.3 0.2 0.1 -0.3 -2.2 -0.4 -0.2 0.5 0.0 0.0
Pack years of smoking 1.1 1.6 7.1 -2.5 0.7 1.0 -0.3 -2.7 -0.3 -0.9 -0.5 0.2 -0.2
Impedance of whole body 0.6 3.1 13.8 3.7 -1.3 -0.2 -1.7 1.2 -1.5 -1.0 -1.2 -1.7 -1.9
Leg fat mass (left) 1.7 6.5 42.0 -6.5 0.9 0.8 0.6 -4.3 0.6 -0.7 -0.4 1.0 0.6
Arm predicted mass (left) 0.3 1.4 9.3 -3.1 0.8 0.4 0.4 -0.9 0.4 0.0 -0.2 1.5 0.5