Hub : Genes

CRTAM

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Ovarian Serous Cystadenocarcinoma	0.066	0.032	0.0044	0.014	0.025	0.023	NA	0.026	3.4e-02	0.0080	0.0100	NA	0.0070
2	TCGA	Soft Tissue Sarcoma	0.105	0.054	0.0030	0.035	0.036	0.045	NA	0.026	3.4e-03	0.0031	0.0011	NA	0.0110
3	TCGA	Thyroid Carcinoma	0.077	0.035	0.0058	0.040	0.010	0.007	NA	0.025	7.6e-05	0.0310	0.0660	NA	0.0015

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.7	4.3	8.1	-2.2	2.8	-0.3
Bipolar Disorder or Schizophrenia	2.4	5.8	8.9	-3.0	2.8	-0.8
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	-1.0	0.5	-0.0
Depression (Nagel 2018)	0.4	0.5	1.6	0.1	-1.3	-0.2
Intelligence (Savage-Jansen 2018)	0.6	1.8	2.7	1.2	1.2	1.6
Neuroticism (Nagel 2018)	1.1	2.5	3.8	-1.9	0.7	-1.8
Schizophrenia (2018)	1.1	2.2	4.3	-2.1	1.4	-0.8
Schizophrenia vs Biploar Disorder	0.7	1.0	2.8	0.3	-1.7	-0.0
Worry (Nagel 2018)	1.6	3.3	5.8	-1.9	0.7	-2.4
Alzheimer’s Disease (in mother)	2.4	2.9	5.7	-0.3	2.4	1.7
Alzheimer’s Disease (in father)	1.4	1.6	3.9	-0.6	2.0	0.6
Alzheimer’s Disease (including proxy)	2.0	2.9	7.0	-0.7	2.6	1.0
Crohns Disease (2017)	0.8	1.7	3.5	1.1	-1.9	0.4
Irritable Bowel Disease (IBD)	0.4	1.0	1.6	1.1	-1.3	0.4
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.6	-0.2	0.4
Major Depression (MDD)	1.2	1.5	3.2	-1.8	1.1	0.3
Reaction Time	0.5	1.0	1.9	-0.7	1.4	-0.8
Verbal and Numeric Reasoning (VNR)	1.0	2.5	4.7	1.7	0.1	2.2
Breast Cancer	0.1	0.2	0.3	0.6	-0.2	-0.6
Ovarian Cancer	0.1	0.2	0.4	0.3	-0.2	-0.6
Prostate Cancer	0.1	0.1	0.3	0.1	-0.6	0.1
Age at First Birth	0.5	0.8	2.1	1.4	-0.1	-0.4
Bipolar Disorder (2011)	0.2	0.2	0.7	-0.8	0.0	0.0
Body Mass Index (BMI) (2010)	1.4	1.9	3.7	1.9	-1.3	-0.6
Coronary Artery Disease (CAD)	0.2	0.3	0.8	0.3	0.9	0.0
Crohns Disease (2012)	0.8	1.3	3.2	0.7	-0.4	1.8
Mean Putamen Volume	0.6	0.7	1.4	0.8	1.2	-0.1
Fasting Glucose	1.1	1.3	2.6	-0.1	1.6	-1.2
HbA1C	1.0	1.1	1.6	1.3	-0.9	-1.0
HDL Cholesterol	1.3	2.2	4.5	-2.1	1.4	0.3
LDL Cholesterol	2.5	4.0	5.7	1.9	-1.7	-2.4
Lupus	0.0	0.0	0.0	0.2	0.2	-0.0
Neuroticism (2016)	0.3	0.5	1.2	-0.5	-0.1	-1.1
Primary Biliary Cirrhosis	0.4	0.6	0.9	0.3	-0.9	0.9
Rheumatoid Arthritis	3.5	4.8	9.2	3.0	-1.7	1.5
Schizophrenia (2014)	1.2	2.7	4.0	-2.0	2.0	0.0
Triglycerides	2.5	4.1	7.6	2.8	-2.1	-0.7
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.5	0.1	0.3
Ulcerative Colitis	0.2	0.3	0.9	-1.0	0.1	0.0
Blood Eosinophil Count	0.2	1.8	2.8	0.2	-1.6	1.7
Blood Platelet Count	0.4	4.2	8.0	2.8	-1.6	1.4
Blood Red Count	0.0	0.0	0.1	0.1	-0.2	-0.2
Blood White Count	0.0	0.2	0.7	-0.2	0.8	-0.1
Heel T-Score	0.6	4.4	7.2	-0.3	2.7	2.5
BMI	0.9	5.1	9.2	3.0	-1.9	1.5
Height	1.6	30.0	50.7	4.9	-7.1	-3.9
Waist Hip Ratio (WHR)	0.7	2.9	6.0	1.5	-2.5	0.8
Systolic Blood Pressure	0.3	1.4	3.2	-1.0	0.1	-1.8
Smoking Status	0.9	2.1	4.5	-2.1	1.4	0.0
Allergy or Eczema	0.1	0.2	0.3	-0.6	0.5	-0.0
Cardiovascular Disease	0.5	1.5	3.9	-2.0	0.4	-0.7
Hypothyroidism (self reported)	0.2	0.5	1.4	-0.2	0.4	1.2
Respiratory disease	0.2	0.5	1.0	1.0	0.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.2	0.9	-1.8	0.6
Lung FEV1/FVC ratio	0.3	1.5	2.7	0.1	-1.6	1.4
Lung FVC	0.3	1.6	3.8	0.8	0.7	-1.9
Neuroticism	0.7	1.7	2.7	-1.4	0.6	-1.6
Chronotype (morning person)	0.2	0.5	0.8	0.9	0.6	0.7
Hair Pigment	0.0	0.6	1.1	0.6	0.5	1.1
Tanning	0.0	0.3	0.7	-0.0	-0.9	-0.2
Hand grip strength (left)	1.1	2.9	4.5	2.0	-2.1	0.3
Number of treatments/medications taken	0.1	0.2	0.4	-0.2	-0.6	-0.2
Average weekly spirits intake	0.3	0.4	0.7	0.8	-0.6	-0.5
Sensitivity / hurt feelings	1.0	1.6	2.0	-1.2	-1.2	-1.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	0.4	-1.2	0.1
Hearing difficulty/problems: Yes	0.5	0.8	1.8	0.2	1.4	0.7
Relative age of first facial hair	6.5	13.3	29.1	1.9	-5.4	-2.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.0	0.3	0.6	1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.1	0.6	0.8
Ever had hysterectomy (womb removed)	0.8	0.9	1.3	-1.1	0.5	-1.1
Systolic blood pressure, automated reading	0.1	0.3	0.6	-0.2	0.8	-0.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.7	-0.3	-1.1	-1.3
Angina	0.5	0.7	1.0	-0.7	-1.0	-0.7
Medication for hormone replacement therapy	0.4	0.4	1.0	-0.2	-0.4	-1.0
Vitamin and mineral supplements	0.3	0.4	0.8	0.5	-0.9	0.3
Supplements: Zinc	0.6	0.7	1.5	0.1	1.2	-0.7
Medication: Co-codamol	0.3	0.4	0.7	-0.3	0.8	0.6
Medication: Metformin	0.1	0.1	0.1	0.2	-0.3	0.3
Diabetes (father)	0.2	0.2	0.6	-0.3	-0.2	-0.8
Diabetes (mother)	0.6	0.8	2.3	-1.5	0.1	-0.2
Severe depression (siblings)	0.3	0.3	0.7	-0.5	-0.8	0.2
Pack years adult smoking proportion	2.5	3.8	7.9	-2.8	0.6	-1.8
Impedance of leg (right)	0.8	3.8	7.0	-2.1	-0.1	-2.7
Leg fat-free mass (left)	1.4	7.4	11.3	3.3	-3.4	0.2
Trunk fat percentage	1.5	6.2	9.4	3.1	-3.0	-0.0
Hand grip strength (right)	0.9	2.5	3.9	2.0	-1.8	0.5
Townsend deprivation index at recruitment	0.5	0.7	1.9	-0.0	-1.4	0.4
Current tobacco smoking	2.4	3.9	11.3	-3.4	0.7	-0.0
Average weekly fortified wine intake	0.6	0.7	1.2	-1.1	0.5	-0.7
Maternal smoking around birth	1.0	1.5	3.4	1.0	-1.8	-0.3
Fed-up feelings	0.7	1.3	2.0	-1.1	-0.8	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.5	-0.6	-1.2	-1.1
Relative age voice broke	5.6	8.6	17.0	2.2	-4.1	-2.0
Taking other prescription medications	0.4	0.6	1.6	0.3	-1.3	-0.0
Age when periods started (menarche)	12.1	29.1	46.5	4.7	-6.8	-4.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.6	0.5	1.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.3	1.5	-0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	-0.3	0.8	0.2
Qualifications: CSEs or equivalent	1.3	1.8	3.2	-1.0	-1.8	-1.0
Serious illness, injury or assault to yourself	1.9	2.3	3.2	-1.7	-0.8	-1.8
High blood pressure	1.6	4.5	7.7	-2.8	1.9	-1.4
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	-0.2	-0.2	-0.6
Multivitamins +/- minerals	0.5	0.7	1.5	0.3	1.2	0.6
Stomach or abdominal pain in last month	1.1	1.4	3.5	-0.8	-0.0	-1.9
Supplements: Glucosamine	0.5	0.7	1.1	1.0	0.3	1.0
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.8	-1.1	1.9	-0.4
Medication: Atenolol	0.7	0.9	2.1	-1.4	0.4	-0.7
Medication: Levothyroxine sodium	0.6	1.0	1.3	-1.1	1.1	0.8
Sitting height	0.5	3.3	6.4	1.7	-2.5	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.5	-0.7	-0.0
High blood pressure (mother)	0.5	0.7	1.1	1.0	0.5	1.0
Body mass index (BMI)	0.6	2.5	3.8	1.9	-1.4	1.2
Impedance of leg (left)	0.6	2.7	5.0	-1.8	-0.2	-2.2
Leg predicted mass (left)	1.4	7.3	11.3	3.2	-3.4	0.2
Trunk fat mass	2.2	9.5	14.7	3.7	-3.8	0.1
Waist circumference	1.7	6.1	11.0	2.5	-3.3	1.0
Number of incorrect matches in round	2.1	3.5	6.4	-2.0	2.5	0.5
Past tobacco smoking	0.1	0.2	0.4	-0.1	-0.3	-0.6
Alcohol usually taken with meals	0.6	1.0	1.4	0.8	-1.0	1.2
Nervous feelings	1.2	2.3	3.9	-2.0	1.5	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	-0.7	0.5	-0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.5	-0.2	-0.0
Hair/balding pattern: Pattern 2	0.8	1.1	1.5	1.0	0.9	1.2
Had menopause	0.1	0.1	0.2	0.2	-0.2	-0.4
Had other major operations	0.3	0.4	0.9	0.5	-1.0	-0.2
Forced vital capacity (FVC)	0.5	2.0	3.3	1.5	-1.8	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.2	0.4	0.5	-0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.0	1.7	-0.4	-0.3
Qualifications: None of the above	0.8	1.8	3.6	1.2	-1.9	0.4
Financial difficulties in last 2 years	0.4	0.6	1.4	-1.2	-0.5	0.3
Mouth/teeth dental problems	2.7	4.1	7.9	-1.6	2.8	1.4
Heart attack	0.1	0.1	0.2	-0.4	-0.3	-0.3
Allergy	0.2	0.4	1.1	-0.1	0.1	1.1
Pain all over the body in last month	1.3	1.4	2.3	-0.7	1.2	1.5
Diabetes (self-reported)	0.0	0.1	0.2	-0.4	0.0	0.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.1	-0.1	-1.1	-1.4
Medication: Ramipril	0.4	0.6	0.9	-0.9	-0.1	-0.9
Medication: Simvastatin	0.3	0.5	0.7	-0.8	-0.3	-0.8
Fluid intelligence score	0.8	1.7	2.6	0.9	1.3	1.6
Illnesses of siblings	0.2	0.3	0.4	0.6	-0.6	-0.4
Neuroticism score	1.4	3.0	5.1	-1.8	0.9	-2.3
Weight	1.6	7.9	12.1	3.3	-3.5	0.7
Impedance of arm (right)	0.4	2.1	5.0	-0.2	-1.1	-2.2
Arm fat percentage (right)	0.9	3.6	5.5	2.2	-2.4	0.5
Trunk fat-free mass	0.8	4.4	8.0	2.2	-2.8	0.6
Hip circumference	1.1	4.6	7.8	2.4	-2.8	0.5
Time employed in main current job	0.2	0.2	0.2	-0.4	-0.5	0.4
Alcohol intake versus 10 years previously	0.3	0.4	0.6	0.6	-0.7	-0.5
Father’s age at death	0.4	0.5	1.2	1.1	-0.4	-0.5
Worrier / anxious feelings	1.0	1.9	2.5	-1.4	1.1	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	0.0	0.5	-1.2
Falls in the last year	0.1	0.2	0.4	0.5	-0.0	0.6
Hair/balding pattern: Pattern 3	1.2	1.7	3.7	-0.9	0.8	-1.9
Number of live births	0.5	0.8	1.7	1.3	-0.7	-0.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	4.8	1.7	-2.2	-0.9
Pulse rate	0.1	0.2	0.2	0.4	-0.4	-0.5
Happiness	1.0	1.2	1.7	-0.7	1.3	-1.1
Noisy workplace	0.1	0.1	0.2	0.4	-0.2	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	-0.4	0.6	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	0.3	-0.2	1.2
Mouth/teeth dental problems: Dentures	0.7	1.2	1.8	1.4	-1.1	-0.7
Asthma	0.2	0.5	0.6	0.7	-0.5	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.3	1.8	-0.7	-0.3
Medication: Cholesterol lowering	1.1	1.8	3.6	-1.0	-0.9	-1.9
Depression (self-reported)	2.5	3.1	4.8	1.1	-1.8	-2.2
Medication: Lansoprazole	1.1	1.2	2.3	1.5	-1.0	-0.6
Prospective memory result	0.7	0.8	1.9	-0.7	0.5	1.4
Lung cancer (father)	1.2	1.4	2.7	1.6	-1.1	0.5
Illnesses of mother	1.1	1.4	2.9	0.1	-1.1	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	3.3	1.8	-1.6	-1.0
Pulse wave Arterial Stiffness index	0.7	0.8	1.9	-1.4	0.6	0.5
Impedance of arm (left)	0.4	1.8	3.5	0.4	-1.3	-1.9
Arm fat mass (right)	1.3	5.4	8.2	2.9	-2.8	0.6
Trunk predicted mass	0.7	4.2	7.5	2.2	-2.7	0.7
Standing height	1.1	10.8	20.7	3.3	-4.5	-0.9
Length of working week for main job	0.1	0.1	0.2	-0.3	0.4	0.3
Exposure to tobacco smoke at home	1.9	2.2	6.2	0.4	-2.5	-0.4
Breastfed as a baby	0.4	0.5	0.5	-0.7	0.6	0.7
Tense / ‘highly strung’	0.7	1.1	2.6	-0.5	0.6	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.8	0.2	-0.2	-1.3
Hair/balding pattern: Pattern 4	0.1	0.4	0.9	0.2	-0.4	-0.9
Birth weight of first child	3.1	5.6	10.5	2.5	0.3	3.2
Peak expiratory flow (PEF)	2.4	5.5	9.1	3.0	-2.6	-0.8
Pulse wave reflection index	0.4	0.5	1.1	-0.3	1.0	0.5
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.1	-0.2	0.2
Loud music exposure frequency	1.9	2.1	3.8	2.0	-1.3	-0.9
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.3	-0.8	1.5	0.0
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	5.9	1.5	-2.4	-1.1
Blood clot in the leg (DVT)	3.1	4.0	6.2	-2.1	2.5	1.2
Medication: Paracetamol	0.2	0.4	0.7	0.4	0.8	-0.5
Headache pain in last month	1.1	1.9	4.9	-0.7	-0.5	-2.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.8	1.7	-0.3	1.3
Glaucoma (self-reported)	1.5	1.8	2.6	-0.9	1.6	1.5
Gout (self-reported)	0.5	0.7	1.6	-0.8	0.2	-1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.6	0.2	0.3	1.2
Medication: Amlodipine	0.2	0.3	0.8	-0.1	-0.2	0.9
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.9	0.6	-1.7	-0.8
Birth weight	1.3	2.8	3.8	1.8	-1.1	2.0
Chronic bronchitis/emphysema (mother)	1.7	2.0	3.4	1.5	0.7	1.8
High blood pressure (siblings)	0.3	0.5	0.8	-0.9	0.6	-0.5
Forced vital capacity (FVC), Best measure	0.6	2.2	3.3	1.8	-1.4	-1.1
Body fat percentage	1.3	5.0	8.1	2.6	-2.9	-0.0
Leg fat percentage (right)	0.5	1.9	3.3	1.4	-1.8	-0.7
Arm fat-free mass (right)	0.9	4.4	6.1	2.5	-2.5	1.1
Exposure to tobacco smoke outside home	0.5	0.6	1.2	0.1	-1.1	-0.8
Comparative body size at age 10	2.4	6.5	17.1	1.3	1.0	4.1
Number of full brothers	0.2	0.2	0.4	0.1	-0.6	0.6
Worry too long after embarrassment	0.4	0.7	1.6	-0.7	-0.1	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	0.0	-0.3
Wheeze or whistling in the chest in last year	1.1	2.0	5.0	0.5	-2.2	-0.9
Number of children fathered	1.0	1.1	2.5	0.9	-0.2	1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.8	-1.3	0.2	-2.0
Age at first live birth	0.5	0.9	1.8	-0.8	1.3	0.4
Pulse wave peak to peak time	1.2	1.4	3.0	1.7	-0.9	-0.6
Health satisfaction	0.5	0.6	1.4	-1.2	0.2	-0.7
Shortness of breath walking on level ground	0.9	1.1	1.9	1.4	-0.7	1.0
Qualifications: College or University degree	0.5	1.5	4.1	0.7	0.0	2.0
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.4	0.2	-0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	-0.1	-0.2	-1.0
Emphysema/chronic bronchitis	0.7	0.8	1.2	0.6	-0.9	-1.1
Medication for pain relief, constipation, heartburn	0.4	0.6	1.5	-1.2	0.5	-0.5
Neck or shoulder pain in last month	0.2	0.3	0.3	-0.6	0.5	-0.4
Medication: Blood pressure	1.2	2.2	4.2	-2.1	1.1	-1.1
Angina (self-reported)	0.3	0.4	0.8	-0.5	-0.9	-0.6
Migraine (self-reported)	2.6	3.2	5.1	-1.5	2.3	1.5
Medication: Ibuprofen	1.5	1.7	4.8	2.2	-0.7	0.2
Medication: Allopurinol	0.1	0.1	0.2	-0.1	0.1	-0.5
Medication: Omeprazole	0.9	1.1	3.2	-0.3	0.0	1.8
Medication: Seretide 50 evohaler	1.0	1.2	3.5	0.2	-0.2	-1.9
Mean time to correctly identify matches	0.7	1.4	3.2	-0.9	1.8	-0.1
Heart disease (mother)	0.6	0.8	1.1	-0.9	0.6	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	0.3	-0.5	0.5
Whole body fat mass	1.9	7.7	13.0	3.2	-3.6	-0.1
Leg fat mass (right)	1.5	5.7	9.3	2.8	-3.0	-0.2
Arm predicted mass (right)	1.1	5.6	8.6	2.7	-2.9	0.8
Pulse rate, automated reading	0.1	0.4	1.1	-1.0	-0.1	-0.1
Alcohol intake frequency.	1.4	3.1	6.3	0.6	-1.7	-2.5
Comparative height size at age 10	0.7	3.9	9.1	1.5	-0.4	3.0
Number of full sisters	0.0	0.0	0.1	-0.0	-0.3	0.0
Suffer from ‘nerves’	3.0	4.8	11.0	-1.1	-1.5	-3.3
Overall health rating	0.1	0.2	0.6	-0.8	-0.4	0.0
Chest pain or discomfort	1.3	1.8	3.6	1.3	-1.9	0.2
Had major operations	1.0	1.2	3.3	-0.5	1.8	-0.1
Age at last live birth	0.2	0.2	0.5	0.4	0.7	0.4
Family relationship satisfaction	0.5	0.6	1.5	-0.6	-0.0	-1.2
Leg pain on walking	1.5	1.9	2.5	1.6	-1.2	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	3.8	-1.1	-0.6	-2.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.0	-0.4	-0.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.5	0.2	0.9	-1.2
Medication: Aspirin	0.4	0.6	1.5	0.1	-1.2	0.5
Supplements: Vitamin C	0.7	0.9	1.9	-0.5	0.7	-1.4
Knee pain experienced in last month	0.5	0.8	2.1	0.3	-0.5	1.5
Hypertension (Self-reported)	1.6	4.4	7.3	-2.7	1.5	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.7	0.5	-0.9	-0.7
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.1	0.6	0.2
Illnesses of siblings: Diabetes	1.0	1.2	2.7	1.6	-0.9	0.3
Smoking status: Previous	0.2	0.4	0.4	0.7	0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	5.9	1.2	-2.4	-1.6
Whole body fat-free mass	1.0	5.7	9.9	2.7	-3.1	0.5
Leg fat-free mass (right)	1.4	7.5	11.3	3.4	-3.3	0.6
Arm fat percentage (left)	1.2	5.0	7.3	2.7	-2.7	0.5
Average weekly red wine intake	1.5	2.3	4.5	-2.1	1.1	-1.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.9	-0.6	1.4	0.0
Mood swings	1.3	2.3	3.7	-1.7	1.9	0.4
Loneliness, isolation	0.0	0.1	0.1	-0.0	-0.3	-0.3
Long-standing illness, disability or infirmity	0.0	0.1	0.2	0.4	-0.1	0.1
Ever had bowel cancer screening	0.3	0.3	0.9	0.2	0.9	-0.2
Diabetes diagnosed by doctor	0.1	0.2	0.3	0.3	-0.3	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.0	0.0	-0.2	2.0
Friendships satisfaction	0.2	0.2	0.4	-0.1	0.6	0.6
Qualifications: nursing, teaching	0.6	1.0	1.6	0.4	1.3	1.1
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.2	0.3	0.4
Eye problems/disorders: Cataract	1.0	1.1	2.5	0.3	-1.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.1	-0.2	-0.5	-1.4
Medication for cholesterol	1.4	2.2	4.2	2.1	-1.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	0.0	-0.7	-0.6
Back pain experienced in last month	0.5	0.8	1.4	0.9	-1.2	0.1
Mineral and other dietary supplements	0.2	0.2	0.5	-0.5	-0.7	-0.1
Breast cancer (self-reported)	0.2	0.2	0.6	-0.1	0.0	0.8
Asthma (self-reported)	0.4	0.8	1.3	0.7	-0.7	-1.1
Osteoporosis (self-reported)	1.0	1.2	2.5	-1.6	0.3	-1.0
Osteoarthritis (self-reported)	1.2	1.6	3.1	1.2	-0.6	1.8
Medication: Aspirin	1.1	1.4	3.7	0.6	-1.9	0.2
Medication: Gliclazide	0.1	0.1	0.3	-0.5	0.4	-0.1
Illnesses of father: None of the above (group 1)	0.9	1.1	1.4	-1.0	1.2	0.9
Smoking status: Current	2.6	4.2	11.8	-3.4	0.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	5.3	1.0	-1.1	-2.3
Whole body water mass	1.0	5.5	9.2	2.7	-3.0	0.5
Leg predicted mass (right)	1.4	7.5	11.4	3.4	-3.3	0.6
Arm fat mass (left)	1.3	5.4	8.0	2.8	-2.8	0.6
Number of self-reported non-cancer illnesses	0.9	1.5	2.2	-1.4	0.6	-1.5
Average weekly champagne plus white wine intake	0.3	0.4	1.0	-0.0	1.0	0.5
Miserableness	1.1	1.9	2.1	-1.4	1.3	-1.4
Guilty feelings	1.8	2.8	4.1	-2.0	0.9	-1.8
Wears glasses or contact lenses	1.0	1.1	2.1	0.6	1.0	1.4
Ever taken oral contraceptive pill	0.9	1.0	2.4	-1.6	0.7	-0.1
Hearing aid user	0.1	0.1	0.3	0.3	-0.5	-0.0
Mother’s age at death	0.2	0.3	0.6	-0.3	-0.4	0.8
Financial situation satisfaction	1.7	2.1	4.5	1.0	-2.1	-1.0
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.5	-1.1	1.2	0.0
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.2	-0.3	0.5
Eye problems/disorders: Glaucoma	0.5	0.5	1.3	0.2	0.5	1.1
Medication: Blood pressure	0.5	0.9	1.6	-1.3	1.0	0.2
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.2	-1.8	1.1	-0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	-0.2	1.0	-0.5
High cholesterol (Self-reported)	0.5	0.9	1.6	-1.3	0.0	-1.1
Medication: Bendroflumethiazide	0.3	0.4	1.0	-1.0	0.5	0.3
Medication: Paracetamol	0.3	0.5	1.3	1.1	-0.1	-0.4
Medication: Lisinopril	2.2	2.8	7.4	-2.7	0.9	-0.6
Medication: Atorvastatin	0.2	0.2	0.5	-0.7	0.3	-0.3
Illnesses of father: High blood pressure	1.3	1.7	2.9	0.7	-1.7	-1.2
Alcohol drinker status: Never	0.7	0.9	1.5	-1.0	0.2	-1.2
Ever smoked	0.2	0.4	0.7	-0.9	0.7	0.2
Basal metabolic rate	1.2	6.6	10.6	3.0	-3.3	0.6
Leg fat percentage (left)	0.6	2.3	4.1	1.7	-2.0	-0.3
Arm fat-free mass (left)	0.6	2.9	4.8	1.8	-2.2	0.7
Number of operations (self-reported)	0.3	0.5	1.0	0.2	1.0	-0.7
Average weekly beer plus cider intake	0.8	1.1	2.0	1.4	0.5	1.0
Irritability	0.6	1.0	2.4	-0.4	1.5	0.6
Risk taking	0.7	1.0	1.5	-1.2	-1.2	-0.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.2	1.1	0.3	-0.9
Fractured/broken bones in last 5 years	0.4	0.5	1.5	-1.2	0.2	0.4
Age started oral contraceptive pill	0.1	0.2	0.4	-0.2	0.4	0.6
Diastolic blood pressure, automated reading	0.1	0.4	0.8	-0.2	-0.9	-0.5
Ever depressed for a whole week	1.6	2.0	3.8	1.5	-2.0	0.2
Unable to work because of sickness or disability	0.3	0.4	1.0	0.1	0.3	1.0
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.3	-0.1	0.0
Myopia	0.9	1.3	3.1	-0.8	1.8	0.6
Vascular/heart problems diagnosed by doctor	1.4	3.9	7.7	2.8	-1.4	1.4
Cholesterol lowering medication	0.8	1.2	3.1	-1.8	0.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.2	-0.5	-0.3	1.1
Pain experienced in last month	0.2	0.3	0.6	-0.1	0.8	-0.4
Supplements: Calcium	1.2	1.3	3.5	-1.9	0.7	-0.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.8	-0.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.5	-0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	2.4	3.0	4.4	-2.0	2.1	0.8
Heart disease (siblings)	1.3	1.6	2.7	-1.1	1.0	1.6
Alcohol drinker status: Previous	0.3	0.4	1.0	0.2	-0.3	1.0
Pack years of smoking	2.7	3.9	8.8	-3.0	1.0	-1.4
Impedance of whole body	0.4	2.3	5.2	-0.7	-1.0	-2.3
Leg fat mass (left)	1.6	6.2	10.2	2.9	-3.2	-0.1
Arm predicted mass (left)	0.6	3.2	5.3	1.9	-2.3	0.7