Hub : Genes

CSF2RB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.3680	0.1020	0.00320	-0.006	NA	-0.008	NA	-0.005	5.8e-01	NA	0.79000	NA	5.2e-01
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0404	0.0164	0.00024	0.038	0.033	0.029	NA	0.035	3.7e-05	0.00012	0.00029	NA	8.1e-05
3	TCGA	Lung Adenocarcinoma	0.0299	0.0155	0.00980	0.006	0.008	0.001	NA	0.005	5.7e-02	0.03300	0.22000	NA	7.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	2.8	-0.3	0.2	-1.7
Bipolar Disorder or Schizophrenia	0.6	1.5	3.6	0.0	-1.9	-0.9
Depressed Affect (Nagel 2018)	0.8	1.6	3.1	0.2	1.8	-1.3
Depression (Nagel 2018)	1.2	1.8	5.0	-0.5	2.2	0.2
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.4	2.1	0.8	1.1
Neuroticism (Nagel 2018)	0.4	1.0	2.3	-0.2	1.5	-0.8
Schizophrenia (2018)	1.1	2.2	6.6	-0.1	-2.6	0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.4	-0.2	0.1
Worry (Nagel 2018)	0.3	0.7	1.4	0.8	1.2	-0.2
Alzheimer’s Disease (in mother)	1.4	1.6	4.4	2.1	0.6	0.2
Alzheimer’s Disease (in father)	0.9	1.0	2.8	-0.1	0.5	1.7
Alzheimer’s Disease (including proxy)	1.4	2.1	6.1	2.5	-0.4	-0.1
Crohns Disease (2017)	4.4	9.8	15.6	-0.5	-3.9	-3.7
Irritable Bowel Disease (IBD)	1.0	2.5	4.4	-0.1	-2.1	-1.7
Ulcerative Colitis (UC)	0.3	0.5	1.0	0.3	0.7	1.0
Major Depression (MDD)	0.9	1.1	2.2	0.9	1.5	-0.5
Reaction Time	0.7	1.3	2.2	-1.5	-1.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.8	0.9	0.4	0.9
Breast Cancer	0.0	0.1	0.1	0.3	-0.1	0.4
Ovarian Cancer	0.2	0.3	0.7	0.0	-0.3	-0.9
Prostate Cancer	0.5	0.7	1.9	1.4	-0.2	-0.1
Age at First Birth	0.2	0.3	0.7	0.2	-0.2	0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	2.8	-0.7	1.0	1.7
Coronary Artery Disease (CAD)	3.3	3.9	7.6	1.4	-2.8	-1.6
Crohns Disease (2012)	4.1	6.6	11.9	1.3	-3.5	-2.4
Mean Putamen Volume	1.5	1.8	5.1	-0.0	0.4	2.3
Fasting Glucose	0.6	0.7	1.3	-0.7	0.6	1.1
HbA1C	1.5	1.7	2.0	-1.1	-1.4	-1.4
HDL Cholesterol	0.9	1.5	4.1	0.6	2.0	-0.2
LDL Cholesterol	0.3	0.4	0.9	-0.6	0.1	-1.0
Lupus	1.1	1.6	3.5	1.0	-0.5	-1.9
Neuroticism (2016)	0.2	0.3	0.3	-0.5	0.5	-0.6
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.4	-0.5	-0.1
Rheumatoid Arthritis	3.0	4.1	11.8	0.7	-3.4	0.4
Schizophrenia (2014)	0.8	1.8	4.8	-0.3	-2.2	-0.8
Triglycerides	0.5	0.8	2.2	-0.5	-0.1	1.5
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.6	-1.3	0.9	0.7
Ulcerative Colitis	2.7	4.0	8.0	-1.2	1.6	2.8
Blood Eosinophil Count	0.6	4.5	9.9	-1.8	-0.3	-3.1
Blood Platelet Count	0.2	2.9	5.5	-1.3	-1.2	-2.3
Blood Red Count	0.9	8.3	23.8	-0.9	4.9	-0.5
Blood White Count	0.1	0.6	1.4	-1.2	0.6	-0.2
Heel T-Score	0.0	0.1	0.3	-0.5	0.2	-0.0
BMI	0.1	0.4	0.7	0.4	0.8	-0.6
Height	0.0	0.6	1.9	-1.4	-0.0	0.1
Waist Hip Ratio (WHR)	0.3	1.3	2.2	1.2	-0.5	-1.5
Systolic Blood Pressure	0.1	0.3	0.6	0.5	0.1	-0.8
Smoking Status	0.3	0.6	1.7	-0.3	0.3	-1.3
Allergy or Eczema	3.1	8.2	24.0	-0.5	-4.9	-0.6
Cardiovascular Disease	0.2	0.7	1.8	0.2	-0.6	-1.3
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.1	0.9	-0.3
Respiratory disease	2.3	5.0	10.5	-0.8	-3.2	-2.0
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	0.8	0.1	-0.3
Lung FEV1/FVC ratio	0.2	1.0	2.5	1.6	0.4	-0.6
Lung FVC	0.2	1.1	3.3	-0.2	-1.8	0.1
Neuroticism	0.8	1.9	4.3	-0.8	1.0	-2.1
Chronotype (morning person)	0.1	0.2	0.3	0.4	-0.5	0.3
Hair Pigment	0.0	1.4	2.6	1.6	-0.0	1.2
Tanning	0.0	0.4	1.3	0.1	-0.0	1.1
Hand grip strength (left)	0.6	1.6	1.8	-1.1	1.3	1.3
Number of treatments/medications taken	1.3	2.2	5.5	2.3	-1.1	-0.1
Average weekly spirits intake	0.3	0.4	0.7	0.4	-0.8	0.6
Sensitivity / hurt feelings	2.6	4.5	8.9	-3.0	0.5	-2.1
Frequency of depressed mood in last 2 weeks	1.9	2.7	7.0	-1.0	2.6	-0.1
Hearing difficulty/problems: Yes	0.8	1.3	1.6	0.8	1.3	1.2
Relative age of first facial hair	0.0	0.0	0.1	0.2	0.1	-0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	0.9	-0.2	0.3
Ever used hormone-replacement therapy (HRT)	2.3	2.9	4.6	-1.4	1.5	2.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	-0.8	0.2	-0.3
Systolic blood pressure, automated reading	0.3	1.0	1.7	1.3	-1.1	0.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.0	-1.0	-0.4	0.5
Angina	0.4	0.5	0.8	-0.7	-0.5	-0.9
Medication for hormone replacement therapy	1.6	1.8	3.7	-0.4	1.3	1.9
Vitamin and mineral supplements	0.4	0.6	0.8	-0.5	0.8	0.9
Supplements: Zinc	0.9	1.0	1.6	1.3	0.9	0.8
Medication: Co-codamol	0.9	1.0	1.8	1.1	-1.3	0.4
Medication: Metformin	1.4	2.0	3.9	2.0	1.4	0.5
Diabetes (father)	2.4	3.0	4.4	0.7	2.1	2.1
Diabetes (mother)	1.7	2.1	5.6	-2.4	-0.7	0.5
Severe depression (siblings)	1.0	1.1	1.8	-1.3	-0.0	1.3
Pack years adult smoking proportion	0.4	0.6	1.1	0.4	1.1	0.7
Impedance of leg (right)	0.1	0.3	0.6	0.5	0.8	0.5
Leg fat-free mass (left)	0.1	0.6	1.6	0.1	0.3	-1.3
Trunk fat percentage	0.0	0.1	0.3	0.1	0.6	-0.3
Hand grip strength (right)	0.4	1.0	2.6	-0.0	1.6	0.5
Townsend deprivation index at recruitment	0.4	0.6	1.2	-0.2	0.8	-1.1
Current tobacco smoking	0.3	0.6	1.4	0.3	1.2	-0.4
Average weekly fortified wine intake	1.2	1.4	2.4	1.5	-1.3	0.5
Maternal smoking around birth	1.5	2.1	4.7	-1.2	0.4	2.2
Fed-up feelings	0.5	1.0	2.0	0.5	0.8	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	4.1	-0.2	2.0	0.3
Relative age voice broke	0.2	0.3	0.7	0.4	-0.8	-0.3
Taking other prescription medications	0.7	1.2	2.0	1.2	-1.4	-0.3
Age when periods started (menarche)	0.4	0.9	1.7	-1.3	-0.7	0.8
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.3	-1.5	0.4	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	4.0	-2.0	0.3	0.6
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.6	1.3	0.2	-1.1
Qualifications: CSEs or equivalent	0.6	0.8	2.2	1.5	-0.1	-0.5
Serious illness, injury or assault to yourself	0.8	1.0	1.9	1.4	0.8	0.7
High blood pressure	0.4	1.0	2.2	0.8	-1.5	-0.5
Hayfever, allergic rhinitis or eczema	3.7	8.1	21.0	0.7	-4.6	-1.6
Multivitamins +/- minerals	0.8	1.1	1.6	0.2	-1.3	-1.2
Stomach or abdominal pain in last month	0.1	0.2	0.2	-0.5	0.5	-0.1
Supplements: Glucosamine	1.4	1.8	3.1	1.4	0.7	1.8
Diverticular disease/diverticulitis (self-reported)	3.1	3.7	7.9	0.6	2.8	1.7
Medication: Atenolol	0.7	0.9	1.5	1.2	-0.5	-0.9
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.2	-0.0	-0.2
Sitting height	0.0	0.1	0.2	0.3	0.4	-0.4
Chronic bronchitis/emphysema (father)	0.6	0.8	2.1	-1.4	-0.1	-0.4
High blood pressure (mother)	0.4	0.5	1.6	-0.2	-0.2	-1.2
Body mass index (BMI)	0.0	0.2	0.6	-0.2	0.7	-0.1
Impedance of leg (left)	0.1	0.3	0.8	-0.1	0.5	0.9
Leg predicted mass (left)	0.1	0.6	1.6	0.1	0.3	-1.3
Trunk fat mass	0.0	0.2	0.4	0.2	0.4	-0.7
Waist circumference	0.1	0.4	1.0	0.1	0.3	-1.0
Number of incorrect matches in round	0.1	0.1	0.3	-0.2	-0.6	-0.1
Past tobacco smoking	0.3	0.5	1.4	0.2	0.2	1.2
Alcohol usually taken with meals	0.8	1.3	1.8	1.0	-1.4	-1.1
Nervous feelings	0.4	0.8	1.5	-0.8	1.2	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.3	0.7	2.1	0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.4	-0.6	0.6	0.5
Hair/balding pattern: Pattern 2	1.7	2.2	2.9	-1.2	-1.7	-1.5
Had menopause	0.4	0.5	1.4	-0.3	-0.1	1.2
Had other major operations	0.1	0.1	0.1	0.3	0.3	0.2
Forced vital capacity (FVC)	0.3	1.1	3.1	-0.1	-0.3	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.2	-1.8	-1.0	-0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.9	0.5	1.4	-0.3
Qualifications: None of the above	0.4	0.8	2.2	-0.5	-0.2	1.5
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.4	0.2	-0.1
Mouth/teeth dental problems	0.5	0.7	1.8	0.3	-0.6	-1.4
Heart attack	0.8	1.1	2.5	1.6	0.7	-0.5
Allergy	4.7	10.9	26.7	1.0	5.2	2.2
Pain all over the body in last month	1.2	1.2	2.0	-1.3	1.4	-0.3
Diabetes (self-reported)	0.5	0.7	1.0	0.8	-0.7	1.0
Hayfever/allergic rhinitis (self-reported)	3.8	5.0	12.8	-1.1	-1.0	-3.6
Medication: Ramipril	0.4	0.5	1.1	0.7	-1.0	-0.1
Medication: Simvastatin	2.1	3.0	9.0	0.0	-3.0	-0.3
Fluid intelligence score	0.6	1.2	3.2	0.7	-0.1	1.8
Illnesses of siblings	0.5	0.7	1.5	0.6	-0.6	-1.2
Neuroticism score	1.3	2.7	6.7	-0.5	1.2	-2.6
Weight	0.1	0.4	0.7	-0.3	0.5	-0.8
Impedance of arm (right)	0.1	0.4	0.8	-0.9	-0.7	-0.3
Arm fat percentage (right)	0.1	0.3	0.6	-0.4	0.5	-0.7
Trunk fat-free mass	0.2	1.1	3.3	0.1	-0.4	-1.8
Hip circumference	0.1	0.3	0.6	-0.3	0.3	-0.8
Time employed in main current job	0.0	0.0	0.1	-0.1	-0.0	0.3
Alcohol intake versus 10 years previously	2.3	3.5	5.3	-2.3	-0.9	-2.1
Father’s age at death	1.3	1.7	2.9	0.1	-1.7	-1.5
Worrier / anxious feelings	0.1	0.2	0.7	-0.0	0.8	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	-0.0	1.0	0.6
Falls in the last year	0.3	0.4	1.1	0.1	1.0	0.1
Hair/balding pattern: Pattern 3	1.0	1.5	3.5	0.7	-0.8	1.9
Number of live births	0.5	0.7	1.3	0.2	0.9	1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.4	0.6	-0.0	-1.9
Pulse rate	0.7	1.2	2.0	-1.1	-1.4	-0.6
Happiness	0.8	0.9	2.0	1.4	0.1	-0.9
Noisy workplace	0.1	0.1	0.2	0.1	0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.1	-1.5	1.4	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.8	0.2	1.4	0.6
Mouth/teeth dental problems: Dentures	1.8	3.0	8.2	0.5	-0.7	2.9
Asthma	2.2	4.3	9.7	-0.4	-3.1	-1.8
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	5.2	2.3	1.8	-0.3
Medication: Cholesterol lowering	1.4	2.1	4.1	1.5	-2.0	0.3
Depression (self-reported)	0.6	0.7	1.1	1.0	1.0	-0.0
Medication: Lansoprazole	2.0	2.3	3.3	-1.8	-1.5	-1.1
Prospective memory result	0.5	0.6	1.6	-1.3	-0.3	-0.3
Lung cancer (father)	0.9	1.0	2.7	0.1	1.6	-0.6
Illnesses of mother	0.4	0.5	1.0	-0.1	1.0	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.2	1.1	-0.3	-2.0
Pulse wave Arterial Stiffness index	0.5	0.6	0.7	0.6	0.8	-0.9
Impedance of arm (left)	0.1	0.4	0.8	-0.4	-0.9	-0.4
Arm fat mass (right)	0.1	0.6	1.0	-0.2	0.8	-1.0
Trunk predicted mass	0.2	1.1	3.1	0.0	-0.4	-1.7
Standing height	0.1	1.4	3.7	0.1	-0.6	-1.9
Length of working week for main job	1.0	1.1	1.9	0.8	0.8	-1.4
Exposure to tobacco smoke at home	1.0	1.1	2.2	-0.9	0.6	1.5
Breastfed as a baby	0.0	0.0	0.0	0.1	0.0	0.1
Tense / ‘highly strung’	0.1	0.1	0.3	-0.5	0.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.1	-0.2	1.8	-0.8
Hair/balding pattern: Pattern 4	0.5	1.1	2.7	0.7	1.6	0.5
Birth weight of first child	0.0	0.0	0.0	0.1	0.2	0.0
Peak expiratory flow (PEF)	0.3	0.8	1.8	0.2	-0.6	-1.4
Pulse wave reflection index	2.3	2.9	3.6	1.9	1.8	1.3
Ever highly irritable/argumentative for 2 days	1.9	2.3	6.2	-0.6	2.5	0.4
Loud music exposure frequency	1.1	1.2	3.5	-0.3	1.9	0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.2	0.1	-1.1	-0.9
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.8	-0.9	0.4	-1.7
Blood clot in the leg (DVT)	0.5	0.6	1.5	-1.2	-0.4	0.3
Medication: Paracetamol	2.0	3.3	9.6	3.1	0.3	0.3
Headache pain in last month	0.6	1.0	1.4	-0.9	1.0	-1.2
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	5.7	-2.4	1.7	-0.2
Glaucoma (self-reported)	0.2	0.2	0.4	0.6	0.6	0.2
Gout (self-reported)	0.3	0.4	0.9	0.2	-1.0	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.5	0.5	-0.1
Medication: Amlodipine	0.9	1.3	2.1	1.4	-1.1	-0.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.2	0.8	-1.5	-1.1
Birth weight	0.2	0.4	0.6	0.6	-0.7	-0.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	-1.4	-0.2	-0.2
High blood pressure (siblings)	0.8	1.1	2.3	-1.5	-0.4	0.9
Forced vital capacity (FVC), Best measure	0.3	1.2	2.7	0.8	-0.6	-1.6
Body fat percentage	0.0	0.1	0.4	0.1	0.6	0.0
Leg fat percentage (right)	0.2	0.6	1.0	0.3	1.0	0.8
Arm fat-free mass (right)	0.1	0.4	1.1	0.5	0.2	-1.0
Exposure to tobacco smoke outside home	0.8	1.1	2.9	1.7	0.4	0.4
Comparative body size at age 10	0.6	1.6	4.4	-0.5	2.1	-0.3
Number of full brothers	2.2	2.7	6.9	1.1	2.6	0.4
Worry too long after embarrassment	1.2	2.0	4.9	-0.8	0.6	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.8	0.9	1.3	-0.2
Wheeze or whistling in the chest in last year	0.7	1.2	2.3	-1.5	-1.0	-0.6
Number of children fathered	0.9	1.1	3.2	0.2	0.1	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.1	-1.1	-0.9	0.8
Age at first live birth	0.5	0.8	2.1	-1.5	0.3	0.5
Pulse wave peak to peak time	0.4	0.5	0.7	-0.7	-0.6	0.8
Health satisfaction	0.3	0.3	0.5	-0.7	-0.6	-0.3
Shortness of breath walking on level ground	0.8	0.9	1.4	-0.3	1.1	1.2
Qualifications: College or University degree	0.3	1.0	2.4	0.2	1.6	-0.7
Eye problems/disorders: None of the above	1.1	1.3	2.3	1.5	-1.2	-0.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.1	-1.5	1.2	-0.2
Emphysema/chronic bronchitis	1.2	1.4	3.2	-0.9	-0.5	-1.8
Medication for pain relief, constipation, heartburn	2.9	4.9	13.0	-3.6	-1.2	0.6
Neck or shoulder pain in last month	0.9	1.3	2.3	1.5	0.0	1.2
Medication: Blood pressure	1.5	2.6	3.8	2.0	-1.7	0.9
Angina (self-reported)	0.6	0.8	1.5	-0.8	-0.6	-1.2
Migraine (self-reported)	0.4	0.5	0.8	0.9	0.7	0.5
Medication: Ibuprofen	1.7	2.1	4.0	2.0	1.5	-0.1
Medication: Allopurinol	0.1	0.2	0.3	-0.2	-0.5	0.6
Medication: Omeprazole	1.3	1.6	2.8	-1.4	-0.2	-1.7
Medication: Seretide 50 evohaler	1.9	2.2	6.2	0.7	0.2	2.5
Mean time to correctly identify matches	1.0	1.9	4.6	-0.9	-2.1	-0.5
Heart disease (mother)	0.2	0.2	0.3	0.5	-0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.2	-1.6	1.8	0.2
Whole body fat mass	0.1	0.3	0.6	0.1	0.8	-0.4
Leg fat mass (right)	0.1	0.6	1.5	0.1	1.2	0.4
Arm predicted mass (right)	0.1	0.5	1.0	0.7	0.2	-1.0
Pulse rate, automated reading	0.5	1.6	2.7	-1.4	-1.6	-0.4
Alcohol intake frequency.	0.6	1.4	4.0	-2.0	-0.1	0.1
Comparative height size at age 10	0.0	0.1	0.3	-0.2	-0.1	-0.6
Number of full sisters	0.3	0.4	1.1	0.4	1.0	0.3
Suffer from ‘nerves’	0.4	0.7	1.8	-0.4	1.4	0.2
Overall health rating	0.6	1.2	2.1	-1.1	-1.5	-0.5
Chest pain or discomfort	0.1	0.1	0.3	-0.1	-0.5	0.2
Had major operations	2.1	2.4	3.4	1.8	-1.0	-1.7
Age at last live birth	0.6	0.9	2.0	-1.4	-0.2	0.9
Family relationship satisfaction	1.6	2.0	3.6	1.9	1.2	-1.0
Leg pain on walking	1.1	1.4	3.4	-0.9	1.8	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.2	1.5	0.6	-0.7
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.4	-0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	1.9	2.4	4.7	-0.9	-1.3	-2.2
Medication: Aspirin	1.8	2.4	6.3	2.5	0.9	0.2
Supplements: Vitamin C	1.5	1.7	3.5	0.9	1.0	1.9
Knee pain experienced in last month	0.4	0.6	1.5	0.2	0.6	1.2
Hypertension (Self-reported)	0.3	0.7	1.9	0.3	-1.4	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.9	-0.8	-0.3	-1.0
Illnesses of father: Heart disease	0.5	0.7	1.5	1.2	0.5	0.7
Illnesses of siblings: Diabetes	0.5	0.6	1.6	-1.3	-0.2	0.2
Smoking status: Previous	0.4	0.5	1.2	-0.5	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.7	1.1	0.2	-1.3
Whole body fat-free mass	0.1	0.8	2.4	0.1	-0.1	-1.6
Leg fat-free mass (right)	0.1	0.4	1.3	-0.1	0.2	-1.1
Arm fat percentage (left)	0.1	0.3	0.5	-0.3	0.4	-0.7
Average weekly red wine intake	0.8	1.2	3.1	1.8	-0.3	-0.7
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.0	0.3	0.2
Mood swings	0.8	1.5	4.2	-0.2	0.5	-2.1
Loneliness, isolation	1.4	1.9	4.2	1.0	2.1	-0.8
Long-standing illness, disability or infirmity	0.1	0.2	0.6	0.2	-0.8	0.1
Ever had bowel cancer screening	0.2	0.2	0.3	-0.6	-0.5	0.4
Diabetes diagnosed by doctor	0.2	0.3	0.6	0.8	-0.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.2	-0.8	0.1
Friendships satisfaction	1.2	1.4	1.6	1.3	-1.1	-1.2
Qualifications: nursing, teaching	0.7	1.1	2.7	0.1	0.7	1.6
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.4	-0.1	0.2
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.7	-0.2	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	-1.0	-0.0	0.1
Medication for cholesterol	0.2	0.3	0.8	-0.9	0.4	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	-0.3	0.3	-0.8
Back pain experienced in last month	0.1	0.2	0.3	-0.3	-0.6	-0.5
Mineral and other dietary supplements	0.9	1.2	3.6	-1.9	-0.1	0.0
Breast cancer (self-reported)	0.1	0.1	0.3	-0.1	-0.5	0.0
Asthma (self-reported)	2.1	4.2	9.6	-0.2	-3.1	-1.8
Osteoporosis (self-reported)	0.4	0.4	0.6	-0.8	0.8	0.3
Osteoarthritis (self-reported)	1.2	1.5	4.0	0.4	-0.6	2.0
Medication: Aspirin	1.0	1.3	3.5	1.9	0.5	0.3
Medication: Gliclazide	0.3	0.3	0.7	0.2	0.4	-0.8
Illnesses of father: None of the above (group 1)	0.6	0.8	1.7	-1.3	0.3	-0.8
Smoking status: Current	0.3	0.4	1.0	-0.0	1.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	-0.5	0.3	-0.3
Whole body water mass	0.2	0.9	2.6	0.0	-0.1	-1.6
Leg predicted mass (right)	0.1	0.4	1.3	-0.1	0.2	-1.1
Arm fat mass (left)	0.2	0.6	1.4	-0.3	0.6	-1.2
Number of self-reported non-cancer illnesses	1.5	2.6	4.7	0.4	-1.7	-2.2
Average weekly champagne plus white wine intake	0.3	0.5	1.3	1.1	0.3	0.1
Miserableness	2.2	3.9	5.8	-0.7	2.3	-2.4
Guilty feelings	0.9	1.3	3.6	1.9	-0.3	-0.4
Wears glasses or contact lenses	0.5	0.5	1.5	-1.2	-0.3	0.0
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.2	0.3	-0.4
Hearing aid user	0.8	0.9	2.5	0.0	0.3	1.6
Mother’s age at death	2.1	2.6	4.8	2.2	-1.6	-0.8
Financial situation satisfaction	0.7	0.8	1.2	1.1	-0.5	-1.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	-0.9	-0.4	-0.4
Commuting to job workplace: Public transport	0.6	0.8	1.2	0.1	-1.0	1.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.0	0.7	1.0	0.6
Medication: Blood pressure	0.1	0.3	0.4	0.3	-0.6	-0.6
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.3	0.7	1.5	1.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.2	1.5	-0.2	0.3
High cholesterol (Self-reported)	1.6	2.9	7.1	1.0	-2.7	-0.7
Medication: Bendroflumethiazide	0.4	0.5	1.1	-1.1	-0.6	0.4
Medication: Paracetamol	1.3	1.9	5.6	2.4	0.1	0.5
Medication: Lisinopril	0.3	0.4	0.7	0.8	-0.5	-0.2
Medication: Atorvastatin	0.9	1.2	3.1	1.8	-0.6	0.2
Illnesses of father: High blood pressure	0.6	0.7	1.9	1.4	0.5	-0.1
Alcohol drinker status: Never	1.3	1.6	2.8	-1.7	-1.0	0.9
Ever smoked	0.3	0.6	1.6	0.0	0.3	-1.3
Basal metabolic rate	0.1	0.8	2.4	-0.0	0.2	-1.5
Leg fat percentage (left)	0.1	0.4	0.7	-0.1	0.6	0.9
Arm fat-free mass (left)	0.2	0.8	2.2	0.3	0.3	-1.5
Number of operations (self-reported)	0.2	0.2	0.5	0.4	0.7	-0.3
Average weekly beer plus cider intake	1.0	1.4	3.4	1.9	0.7	-0.5
Irritability	1.1	1.9	2.1	-1.3	1.5	-1.4
Risk taking	0.6	0.8	0.9	0.9	-0.9	-1.0
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.6	0.7	-1.0	-1.6
Fractured/broken bones in last 5 years	0.1	0.1	0.4	-0.6	-0.0	-0.3
Age started oral contraceptive pill	0.3	0.4	0.4	-0.6	-0.6	0.6
Diastolic blood pressure, automated reading	0.2	0.7	0.9	0.7	0.9	0.9
Ever depressed for a whole week	0.4	0.5	1.1	-0.1	1.0	0.7
Unable to work because of sickness or disability	0.3	0.4	1.0	-1.0	0.0	0.3
Commuting to job workplace: Cycle	2.6	3.2	6.1	1.3	2.5	1.3
Myopia	1.7	2.5	6.9	0.1	-0.8	-2.6
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.5	-0.5	1.2	0.5
Cholesterol lowering medication	1.0	1.5	2.8	-0.1	-1.7	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.9	-1.0	0.1	-1.4
Pain experienced in last month	0.8	1.3	2.7	-0.3	-1.6	-1.0
Supplements: Calcium	0.5	0.5	0.9	0.9	-0.9	-0.1
Basal cell carcinoma (self-reported)	1.1	1.3	2.3	0.4	-1.2	1.5
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.9	1.7	0.8	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.1	-1.5	-0.6	0.5
Heart disease (siblings)	0.5	0.6	0.9	0.8	0.9	-0.5
Alcohol drinker status: Previous	0.5	0.6	1.4	0.2	-0.6	1.2
Pack years of smoking	0.5	0.7	1.4	0.2	1.2	0.9
Impedance of whole body	0.0	0.0	0.0	-0.1	-0.2	0.1
Leg fat mass (left)	0.1	0.3	0.9	0.0	1.0	0.3
Arm predicted mass (left)	0.2	0.9	2.3	0.3	0.3	-1.5