Hub : Genes

CSF2RB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Sigmoid 0.3680 0.1020 0.00320 -0.006 NA -0.008 NA -0.005 5.8e-01 NA 0.79000 NA 5.2e-01
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0404 0.0164 0.00024 0.038 0.033 0.029 NA 0.035 3.7e-05 0.00012 0.00029 NA 8.1e-05
3 TCGA Lung Adenocarcinoma 0.0299 0.0155 0.00980 0.006 0.008 0.001 NA 0.005 5.7e-02 0.03300 0.22000 NA 7.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 1.0 2.8 -0.3 0.2 -1.7
Bipolar Disorder or Schizophrenia 0.6 1.5 3.6 0.0 -1.9 -0.9
Depressed Affect (Nagel 2018) 0.8 1.6 3.1 0.2 1.8 -1.3
Depression (Nagel 2018) 1.2 1.8 5.0 -0.5 2.2 0.2
Intelligence (Savage-Jansen 2018) 0.7 2.1 4.4 2.1 0.8 1.1
Neuroticism (Nagel 2018) 0.4 1.0 2.3 -0.2 1.5 -0.8
Schizophrenia (2018) 1.1 2.2 6.6 -0.1 -2.6 0.2
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.4 -0.2 0.1
Worry (Nagel 2018) 0.3 0.7 1.4 0.8 1.2 -0.2
Alzheimer’s Disease (in mother) 1.4 1.6 4.4 2.1 0.6 0.2
Alzheimer’s Disease (in father) 0.9 1.0 2.8 -0.1 0.5 1.7
Alzheimer’s Disease (including proxy) 1.4 2.1 6.1 2.5 -0.4 -0.1
Crohns Disease (2017) 4.4 9.8 15.6 -0.5 -3.9 -3.7
Irritable Bowel Disease (IBD) 1.0 2.5 4.4 -0.1 -2.1 -1.7
Ulcerative Colitis (UC) 0.3 0.5 1.0 0.3 0.7 1.0
Major Depression (MDD) 0.9 1.1 2.2 0.9 1.5 -0.5
Reaction Time 0.7 1.3 2.2 -1.5 -1.1 -0.8
Verbal and Numeric Reasoning (VNR) 0.2 0.6 0.8 0.9 0.4 0.9
Breast Cancer 0.0 0.1 0.1 0.3 -0.1 0.4
Ovarian Cancer 0.2 0.3 0.7 0.0 -0.3 -0.9
Prostate Cancer 0.5 0.7 1.9 1.4 -0.2 -0.1
Age at First Birth 0.2 0.3 0.7 0.2 -0.2 0.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.4 2.8 -0.7 1.0 1.7
Coronary Artery Disease (CAD) 3.3 3.9 7.6 1.4 -2.8 -1.6
Crohns Disease (2012) 4.1 6.6 11.9 1.3 -3.5 -2.4
Mean Putamen Volume 1.5 1.8 5.1 -0.0 0.4 2.3
Fasting Glucose 0.6 0.7 1.3 -0.7 0.6 1.1
HbA1C 1.5 1.7 2.0 -1.1 -1.4 -1.4
HDL Cholesterol 0.9 1.5 4.1 0.6 2.0 -0.2
LDL Cholesterol 0.3 0.4 0.9 -0.6 0.1 -1.0
Lupus 1.1 1.6 3.5 1.0 -0.5 -1.9
Neuroticism (2016) 0.2 0.3 0.3 -0.5 0.5 -0.6
Primary Biliary Cirrhosis 0.1 0.1 0.2 -0.4 -0.5 -0.1
Rheumatoid Arthritis 3.0 4.1 11.8 0.7 -3.4 0.4
Schizophrenia (2014) 0.8 1.8 4.8 -0.3 -2.2 -0.8
Triglycerides 0.5 0.8 2.2 -0.5 -0.1 1.5
Type 2 Diabetes (T2D) (2012) 0.9 1.0 1.6 -1.3 0.9 0.7
Ulcerative Colitis 2.7 4.0 8.0 -1.2 1.6 2.8
Blood Eosinophil Count 0.6 4.5 9.9 -1.8 -0.3 -3.1
Blood Platelet Count 0.2 2.9 5.5 -1.3 -1.2 -2.3
Blood Red Count 0.9 8.3 23.8 -0.9 4.9 -0.5
Blood White Count 0.1 0.6 1.4 -1.2 0.6 -0.2
Heel T-Score 0.0 0.1 0.3 -0.5 0.2 -0.0
BMI 0.1 0.4 0.7 0.4 0.8 -0.6
Height 0.0 0.6 1.9 -1.4 -0.0 0.1
Waist Hip Ratio (WHR) 0.3 1.3 2.2 1.2 -0.5 -1.5
Systolic Blood Pressure 0.1 0.3 0.6 0.5 0.1 -0.8
Smoking Status 0.3 0.6 1.7 -0.3 0.3 -1.3
Allergy or Eczema 3.1 8.2 24.0 -0.5 -4.9 -0.6
Cardiovascular Disease 0.2 0.7 1.8 0.2 -0.6 -1.3
Hypothyroidism (self reported) 0.1 0.3 0.7 -0.1 0.9 -0.3
Respiratory disease 2.3 5.0 10.5 -0.8 -3.2 -2.0
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 0.8 0.1 -0.3
Lung FEV1/FVC ratio 0.2 1.0 2.5 1.6 0.4 -0.6
Lung FVC 0.2 1.1 3.3 -0.2 -1.8 0.1
Neuroticism 0.8 1.9 4.3 -0.8 1.0 -2.1
Chronotype (morning person) 0.1 0.2 0.3 0.4 -0.5 0.3
Hair Pigment 0.0 1.4 2.6 1.6 -0.0 1.2
Tanning 0.0 0.4 1.3 0.1 -0.0 1.1
Hand grip strength (left) 0.6 1.6 1.8 -1.1 1.3 1.3
Number of treatments/medications taken 1.3 2.2 5.5 2.3 -1.1 -0.1
Average weekly spirits intake 0.3 0.4 0.7 0.4 -0.8 0.6
Sensitivity / hurt feelings 2.6 4.5 8.9 -3.0 0.5 -2.1
Frequency of depressed mood in last 2 weeks 1.9 2.7 7.0 -1.0 2.6 -0.1
Hearing difficulty/problems: Yes 0.8 1.3 1.6 0.8 1.3 1.2
Relative age of first facial hair 0.0 0.0 0.1 0.2 0.1 -0.3
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 0.9 -0.2 0.3
Ever used hormone-replacement therapy (HRT) 2.3 2.9 4.6 -1.4 1.5 2.1
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 -0.8 0.2 -0.3
Systolic blood pressure, automated reading 0.3 1.0 1.7 1.3 -1.1 0.4
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.0 -1.0 -0.4 0.5
Angina 0.4 0.5 0.8 -0.7 -0.5 -0.9
Medication for hormone replacement therapy 1.6 1.8 3.7 -0.4 1.3 1.9
Vitamin and mineral supplements 0.4 0.6 0.8 -0.5 0.8 0.9
Supplements: Zinc 0.9 1.0 1.6 1.3 0.9 0.8
Medication: Co-codamol 0.9 1.0 1.8 1.1 -1.3 0.4
Medication: Metformin 1.4 2.0 3.9 2.0 1.4 0.5
Diabetes (father) 2.4 3.0 4.4 0.7 2.1 2.1
Diabetes (mother) 1.7 2.1 5.6 -2.4 -0.7 0.5
Severe depression (siblings) 1.0 1.1 1.8 -1.3 -0.0 1.3
Pack years adult smoking proportion 0.4 0.6 1.1 0.4 1.1 0.7
Impedance of leg (right) 0.1 0.3 0.6 0.5 0.8 0.5
Leg fat-free mass (left) 0.1 0.6 1.6 0.1 0.3 -1.3
Trunk fat percentage 0.0 0.1 0.3 0.1 0.6 -0.3
Hand grip strength (right) 0.4 1.0 2.6 -0.0 1.6 0.5
Townsend deprivation index at recruitment 0.4 0.6 1.2 -0.2 0.8 -1.1
Current tobacco smoking 0.3 0.6 1.4 0.3 1.2 -0.4
Average weekly fortified wine intake 1.2 1.4 2.4 1.5 -1.3 0.5
Maternal smoking around birth 1.5 2.1 4.7 -1.2 0.4 2.2
Fed-up feelings 0.5 1.0 2.0 0.5 0.8 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 4.1 -0.2 2.0 0.3
Relative age voice broke 0.2 0.3 0.7 0.4 -0.8 -0.3
Taking other prescription medications 0.7 1.2 2.0 1.2 -1.4 -0.3
Age when periods started (menarche) 0.4 0.9 1.7 -1.3 -0.7 0.8
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 2.3 -1.5 0.4 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 4.0 -2.0 0.3 0.6
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 1.6 1.3 0.2 -1.1
Qualifications: CSEs or equivalent 0.6 0.8 2.2 1.5 -0.1 -0.5
Serious illness, injury or assault to yourself 0.8 1.0 1.9 1.4 0.8 0.7
High blood pressure 0.4 1.0 2.2 0.8 -1.5 -0.5
Hayfever, allergic rhinitis or eczema 3.7 8.1 21.0 0.7 -4.6 -1.6
Multivitamins +/- minerals 0.8 1.1 1.6 0.2 -1.3 -1.2
Stomach or abdominal pain in last month 0.1 0.2 0.2 -0.5 0.5 -0.1
Supplements: Glucosamine 1.4 1.8 3.1 1.4 0.7 1.8
Diverticular disease/diverticulitis (self-reported) 3.1 3.7 7.9 0.6 2.8 1.7
Medication: Atenolol 0.7 0.9 1.5 1.2 -0.5 -0.9
Medication: Levothyroxine sodium 0.0 0.0 0.0 -0.2 -0.0 -0.2
Sitting height 0.0 0.1 0.2 0.3 0.4 -0.4
Chronic bronchitis/emphysema (father) 0.6 0.8 2.1 -1.4 -0.1 -0.4
High blood pressure (mother) 0.4 0.5 1.6 -0.2 -0.2 -1.2
Body mass index (BMI) 0.0 0.2 0.6 -0.2 0.7 -0.1
Impedance of leg (left) 0.1 0.3 0.8 -0.1 0.5 0.9
Leg predicted mass (left) 0.1 0.6 1.6 0.1 0.3 -1.3
Trunk fat mass 0.0 0.2 0.4 0.2 0.4 -0.7
Waist circumference 0.1 0.4 1.0 0.1 0.3 -1.0
Number of incorrect matches in round 0.1 0.1 0.3 -0.2 -0.6 -0.1
Past tobacco smoking 0.3 0.5 1.4 0.2 0.2 1.2
Alcohol usually taken with meals 0.8 1.3 1.8 1.0 -1.4 -1.1
Nervous feelings 0.4 0.8 1.5 -0.8 1.2 -0.5
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 4.3 0.7 2.1 0.5
Hearing difficulty/problems with background noise 0.2 0.3 0.4 -0.6 0.6 0.5
Hair/balding pattern: Pattern 2 1.7 2.2 2.9 -1.2 -1.7 -1.5
Had menopause 0.4 0.5 1.4 -0.3 -0.1 1.2
Had other major operations 0.1 0.1 0.1 0.3 0.3 0.2
Forced vital capacity (FVC) 0.3 1.1 3.1 -0.1 -0.3 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.2 -1.8 -1.0 -0.2
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.9 0.5 1.4 -0.3
Qualifications: None of the above 0.4 0.8 2.2 -0.5 -0.2 1.5
Financial difficulties in last 2 years 0.1 0.1 0.2 -0.4 0.2 -0.1
Mouth/teeth dental problems 0.5 0.7 1.8 0.3 -0.6 -1.4
Heart attack 0.8 1.1 2.5 1.6 0.7 -0.5
Allergy 4.7 10.9 26.7 1.0 5.2 2.2
Pain all over the body in last month 1.2 1.2 2.0 -1.3 1.4 -0.3
Diabetes (self-reported) 0.5 0.7 1.0 0.8 -0.7 1.0
Hayfever/allergic rhinitis (self-reported) 3.8 5.0 12.8 -1.1 -1.0 -3.6
Medication: Ramipril 0.4 0.5 1.1 0.7 -1.0 -0.1
Medication: Simvastatin 2.1 3.0 9.0 0.0 -3.0 -0.3
Fluid intelligence score 0.6 1.2 3.2 0.7 -0.1 1.8
Illnesses of siblings 0.5 0.7 1.5 0.6 -0.6 -1.2
Neuroticism score 1.3 2.7 6.7 -0.5 1.2 -2.6
Weight 0.1 0.4 0.7 -0.3 0.5 -0.8
Impedance of arm (right) 0.1 0.4 0.8 -0.9 -0.7 -0.3
Arm fat percentage (right) 0.1 0.3 0.6 -0.4 0.5 -0.7
Trunk fat-free mass 0.2 1.1 3.3 0.1 -0.4 -1.8
Hip circumference 0.1 0.3 0.6 -0.3 0.3 -0.8
Time employed in main current job 0.0 0.0 0.1 -0.1 -0.0 0.3
Alcohol intake versus 10 years previously 2.3 3.5 5.3 -2.3 -0.9 -2.1
Father’s age at death 1.3 1.7 2.9 0.1 -1.7 -1.5
Worrier / anxious feelings 0.1 0.2 0.7 -0.0 0.8 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.0 -0.0 1.0 0.6
Falls in the last year 0.3 0.4 1.1 0.1 1.0 0.1
Hair/balding pattern: Pattern 3 1.0 1.5 3.5 0.7 -0.8 1.9
Number of live births 0.5 0.7 1.3 0.2 0.9 1.1
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 3.4 0.6 -0.0 -1.9
Pulse rate 0.7 1.2 2.0 -1.1 -1.4 -0.6
Happiness 0.8 0.9 2.0 1.4 0.1 -0.9
Noisy workplace 0.1 0.1 0.2 0.1 0.4 -0.4
Qualifications: A levels/AS levels or equivalent 0.6 1.4 2.1 -1.5 1.4 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.8 0.2 1.4 0.6
Mouth/teeth dental problems: Dentures 1.8 3.0 8.2 0.5 -0.7 2.9
Asthma 2.2 4.3 9.7 -0.4 -3.1 -1.8
Medication: Ibuprofen (e.g. Nurofen) 2.3 2.9 5.2 2.3 1.8 -0.3
Medication: Cholesterol lowering 1.4 2.1 4.1 1.5 -2.0 0.3
Depression (self-reported) 0.6 0.7 1.1 1.0 1.0 -0.0
Medication: Lansoprazole 2.0 2.3 3.3 -1.8 -1.5 -1.1
Prospective memory result 0.5 0.6 1.6 -1.3 -0.3 -0.3
Lung cancer (father) 0.9 1.0 2.7 0.1 1.6 -0.6
Illnesses of mother 0.4 0.5 1.0 -0.1 1.0 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 4.2 1.1 -0.3 -2.0
Pulse wave Arterial Stiffness index 0.5 0.6 0.7 0.6 0.8 -0.9
Impedance of arm (left) 0.1 0.4 0.8 -0.4 -0.9 -0.4
Arm fat mass (right) 0.1 0.6 1.0 -0.2 0.8 -1.0
Trunk predicted mass 0.2 1.1 3.1 0.0 -0.4 -1.7
Standing height 0.1 1.4 3.7 0.1 -0.6 -1.9
Length of working week for main job 1.0 1.1 1.9 0.8 0.8 -1.4
Exposure to tobacco smoke at home 1.0 1.1 2.2 -0.9 0.6 1.5
Breastfed as a baby 0.0 0.0 0.0 0.1 0.0 0.1
Tense / ‘highly strung’ 0.1 0.1 0.3 -0.5 0.1 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 3.1 -0.2 1.8 -0.8
Hair/balding pattern: Pattern 4 0.5 1.1 2.7 0.7 1.6 0.5
Birth weight of first child 0.0 0.0 0.0 0.1 0.2 0.0
Peak expiratory flow (PEF) 0.3 0.8 1.8 0.2 -0.6 -1.4
Pulse wave reflection index 2.3 2.9 3.6 1.9 1.8 1.3
Ever highly irritable/argumentative for 2 days 1.9 2.3 6.2 -0.6 2.5 0.4
Loud music exposure frequency 1.1 1.2 3.5 -0.3 1.9 0.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.2 0.1 -1.1 -0.9
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.8 -0.9 0.4 -1.7
Blood clot in the leg (DVT) 0.5 0.6 1.5 -1.2 -0.4 0.3
Medication: Paracetamol 2.0 3.3 9.6 3.1 0.3 0.3
Headache pain in last month 0.6 1.0 1.4 -0.9 1.0 -1.2
Medication for cholesterol, blood pressure or diabetes 1.7 2.9 5.7 -2.4 1.7 -0.2
Glaucoma (self-reported) 0.2 0.2 0.4 0.6 0.6 0.2
Gout (self-reported) 0.3 0.4 0.9 0.2 -1.0 -0.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.3 -0.5 0.5 -0.1
Medication: Amlodipine 0.9 1.3 2.1 1.4 -1.1 -0.7
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.2 0.8 -1.5 -1.1
Birth weight 0.2 0.4 0.6 0.6 -0.7 -0.5
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.0 -1.4 -0.2 -0.2
High blood pressure (siblings) 0.8 1.1 2.3 -1.5 -0.4 0.9
Forced vital capacity (FVC), Best measure 0.3 1.2 2.7 0.8 -0.6 -1.6
Body fat percentage 0.0 0.1 0.4 0.1 0.6 0.0
Leg fat percentage (right) 0.2 0.6 1.0 0.3 1.0 0.8
Arm fat-free mass (right) 0.1 0.4 1.1 0.5 0.2 -1.0
Exposure to tobacco smoke outside home 0.8 1.1 2.9 1.7 0.4 0.4
Comparative body size at age 10 0.6 1.6 4.4 -0.5 2.1 -0.3
Number of full brothers 2.2 2.7 6.9 1.1 2.6 0.4
Worry too long after embarrassment 1.2 2.0 4.9 -0.8 0.6 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.8 0.9 1.3 -0.2
Wheeze or whistling in the chest in last year 0.7 1.2 2.3 -1.5 -1.0 -0.6
Number of children fathered 0.9 1.1 3.2 0.2 0.1 1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.1 -1.1 -0.9 0.8
Age at first live birth 0.5 0.8 2.1 -1.5 0.3 0.5
Pulse wave peak to peak time 0.4 0.5 0.7 -0.7 -0.6 0.8
Health satisfaction 0.3 0.3 0.5 -0.7 -0.6 -0.3
Shortness of breath walking on level ground 0.8 0.9 1.4 -0.3 1.1 1.2
Qualifications: College or University degree 0.3 1.0 2.4 0.2 1.6 -0.7
Eye problems/disorders: None of the above 1.1 1.3 2.3 1.5 -1.2 -0.4
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.1 -1.5 1.2 -0.2
Emphysema/chronic bronchitis 1.2 1.4 3.2 -0.9 -0.5 -1.8
Medication for pain relief, constipation, heartburn 2.9 4.9 13.0 -3.6 -1.2 0.6
Neck or shoulder pain in last month 0.9 1.3 2.3 1.5 0.0 1.2
Medication: Blood pressure 1.5 2.6 3.8 2.0 -1.7 0.9
Angina (self-reported) 0.6 0.8 1.5 -0.8 -0.6 -1.2
Migraine (self-reported) 0.4 0.5 0.8 0.9 0.7 0.5
Medication: Ibuprofen 1.7 2.1 4.0 2.0 1.5 -0.1
Medication: Allopurinol 0.1 0.2 0.3 -0.2 -0.5 0.6
Medication: Omeprazole 1.3 1.6 2.8 -1.4 -0.2 -1.7
Medication: Seretide 50 evohaler 1.9 2.2 6.2 0.7 0.2 2.5
Mean time to correctly identify matches 1.0 1.9 4.6 -0.9 -2.1 -0.5
Heart disease (mother) 0.2 0.2 0.3 0.5 -0.6 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.2 -1.6 1.8 0.2
Whole body fat mass 0.1 0.3 0.6 0.1 0.8 -0.4
Leg fat mass (right) 0.1 0.6 1.5 0.1 1.2 0.4
Arm predicted mass (right) 0.1 0.5 1.0 0.7 0.2 -1.0
Pulse rate, automated reading 0.5 1.6 2.7 -1.4 -1.6 -0.4
Alcohol intake frequency. 0.6 1.4 4.0 -2.0 -0.1 0.1
Comparative height size at age 10 0.0 0.1 0.3 -0.2 -0.1 -0.6
Number of full sisters 0.3 0.4 1.1 0.4 1.0 0.3
Suffer from ‘nerves’ 0.4 0.7 1.8 -0.4 1.4 0.2
Overall health rating 0.6 1.2 2.1 -1.1 -1.5 -0.5
Chest pain or discomfort 0.1 0.1 0.3 -0.1 -0.5 0.2
Had major operations 2.1 2.4 3.4 1.8 -1.0 -1.7
Age at last live birth 0.6 0.9 2.0 -1.4 -0.2 0.9
Family relationship satisfaction 1.6 2.0 3.6 1.9 1.2 -1.0
Leg pain on walking 1.1 1.4 3.4 -0.9 1.8 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.2 1.5 0.6 -0.7
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.1 -0.4 -0.3 -0.1
Illness, injury, bereavement, stress in last 2 years 1.9 2.4 4.7 -0.9 -1.3 -2.2
Medication: Aspirin 1.8 2.4 6.3 2.5 0.9 0.2
Supplements: Vitamin C 1.5 1.7 3.5 0.9 1.0 1.9
Knee pain experienced in last month 0.4 0.6 1.5 0.2 0.6 1.2
Hypertension (Self-reported) 0.3 0.7 1.9 0.3 -1.4 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 0.9 -0.8 -0.3 -1.0
Illnesses of father: Heart disease 0.5 0.7 1.5 1.2 0.5 0.7
Illnesses of siblings: Diabetes 0.5 0.6 1.6 -1.3 -0.2 0.2
Smoking status: Previous 0.4 0.5 1.2 -0.5 -0.3 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.7 1.1 0.2 -1.3
Whole body fat-free mass 0.1 0.8 2.4 0.1 -0.1 -1.6
Leg fat-free mass (right) 0.1 0.4 1.3 -0.1 0.2 -1.1
Arm fat percentage (left) 0.1 0.3 0.5 -0.3 0.4 -0.7
Average weekly red wine intake 0.8 1.2 3.1 1.8 -0.3 -0.7
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 0.0 0.3 0.2
Mood swings 0.8 1.5 4.2 -0.2 0.5 -2.1
Loneliness, isolation 1.4 1.9 4.2 1.0 2.1 -0.8
Long-standing illness, disability or infirmity 0.1 0.2 0.6 0.2 -0.8 0.1
Ever had bowel cancer screening 0.2 0.2 0.3 -0.6 -0.5 0.4
Diabetes diagnosed by doctor 0.2 0.3 0.6 0.8 -0.5 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 0.2 -0.8 0.1
Friendships satisfaction 1.2 1.4 1.6 1.3 -1.1 -1.2
Qualifications: nursing, teaching 0.7 1.1 2.7 0.1 0.7 1.6
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.4 -0.1 0.2
Eye problems/disorders: Cataract 0.2 0.2 0.5 -0.7 -0.2 0.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.0 -1.0 -0.0 0.1
Medication for cholesterol 0.2 0.3 0.8 -0.9 0.4 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.7 -0.3 0.3 -0.8
Back pain experienced in last month 0.1 0.2 0.3 -0.3 -0.6 -0.5
Mineral and other dietary supplements 0.9 1.2 3.6 -1.9 -0.1 0.0
Breast cancer (self-reported) 0.1 0.1 0.3 -0.1 -0.5 0.0
Asthma (self-reported) 2.1 4.2 9.6 -0.2 -3.1 -1.8
Osteoporosis (self-reported) 0.4 0.4 0.6 -0.8 0.8 0.3
Osteoarthritis (self-reported) 1.2 1.5 4.0 0.4 -0.6 2.0
Medication: Aspirin 1.0 1.3 3.5 1.9 0.5 0.3
Medication: Gliclazide 0.3 0.3 0.7 0.2 0.4 -0.8
Illnesses of father: None of the above (group 1) 0.6 0.8 1.7 -1.3 0.3 -0.8
Smoking status: Current 0.3 0.4 1.0 -0.0 1.0 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.2 -0.5 0.3 -0.3
Whole body water mass 0.2 0.9 2.6 0.0 -0.1 -1.6
Leg predicted mass (right) 0.1 0.4 1.3 -0.1 0.2 -1.1
Arm fat mass (left) 0.2 0.6 1.4 -0.3 0.6 -1.2
Number of self-reported non-cancer illnesses 1.5 2.6 4.7 0.4 -1.7 -2.2
Average weekly champagne plus white wine intake 0.3 0.5 1.3 1.1 0.3 0.1
Miserableness 2.2 3.9 5.8 -0.7 2.3 -2.4
Guilty feelings 0.9 1.3 3.6 1.9 -0.3 -0.4
Wears glasses or contact lenses 0.5 0.5 1.5 -1.2 -0.3 0.0
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.2 0.3 -0.4
Hearing aid user 0.8 0.9 2.5 0.0 0.3 1.6
Mother’s age at death 2.1 2.6 4.8 2.2 -1.6 -0.8
Financial situation satisfaction 0.7 0.8 1.2 1.1 -0.5 -1.0
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.7 -0.9 -0.4 -0.4
Commuting to job workplace: Public transport 0.6 0.8 1.2 0.1 -1.0 1.1
Eye problems/disorders: Glaucoma 0.5 0.6 1.0 0.7 1.0 0.6
Medication: Blood pressure 0.1 0.3 0.4 0.3 -0.6 -0.6
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.3 0.7 1.5 1.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.2 1.5 -0.2 0.3
High cholesterol (Self-reported) 1.6 2.9 7.1 1.0 -2.7 -0.7
Medication: Bendroflumethiazide 0.4 0.5 1.1 -1.1 -0.6 0.4
Medication: Paracetamol 1.3 1.9 5.6 2.4 0.1 0.5
Medication: Lisinopril 0.3 0.4 0.7 0.8 -0.5 -0.2
Medication: Atorvastatin 0.9 1.2 3.1 1.8 -0.6 0.2
Illnesses of father: High blood pressure 0.6 0.7 1.9 1.4 0.5 -0.1
Alcohol drinker status: Never 1.3 1.6 2.8 -1.7 -1.0 0.9
Ever smoked 0.3 0.6 1.6 0.0 0.3 -1.3
Basal metabolic rate 0.1 0.8 2.4 -0.0 0.2 -1.5
Leg fat percentage (left) 0.1 0.4 0.7 -0.1 0.6 0.9
Arm fat-free mass (left) 0.2 0.8 2.2 0.3 0.3 -1.5
Number of operations (self-reported) 0.2 0.2 0.5 0.4 0.7 -0.3
Average weekly beer plus cider intake 1.0 1.4 3.4 1.9 0.7 -0.5
Irritability 1.1 1.9 2.1 -1.3 1.5 -1.4
Risk taking 0.6 0.8 0.9 0.9 -0.9 -1.0
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.6 0.7 -1.0 -1.6
Fractured/broken bones in last 5 years 0.1 0.1 0.4 -0.6 -0.0 -0.3
Age started oral contraceptive pill 0.3 0.4 0.4 -0.6 -0.6 0.6
Diastolic blood pressure, automated reading 0.2 0.7 0.9 0.7 0.9 0.9
Ever depressed for a whole week 0.4 0.5 1.1 -0.1 1.0 0.7
Unable to work because of sickness or disability 0.3 0.4 1.0 -1.0 0.0 0.3
Commuting to job workplace: Cycle 2.6 3.2 6.1 1.3 2.5 1.3
Myopia 1.7 2.5 6.9 0.1 -0.8 -2.6
Vascular/heart problems diagnosed by doctor 0.2 0.7 1.5 -0.5 1.2 0.5
Cholesterol lowering medication 1.0 1.5 2.8 -0.1 -1.7 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.9 -1.0 0.1 -1.4
Pain experienced in last month 0.8 1.3 2.7 -0.3 -1.6 -1.0
Supplements: Calcium 0.5 0.5 0.9 0.9 -0.9 -0.1
Basal cell carcinoma (self-reported) 1.1 1.3 2.3 0.4 -1.2 1.5
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.9 1.7 0.8 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.1 -1.5 -0.6 0.5
Heart disease (siblings) 0.5 0.6 0.9 0.8 0.9 -0.5
Alcohol drinker status: Previous 0.5 0.6 1.4 0.2 -0.6 1.2
Pack years of smoking 0.5 0.7 1.4 0.2 1.2 0.9
Impedance of whole body 0.0 0.0 0.0 -0.1 -0.2 0.1
Leg fat mass (left) 0.1 0.3 0.9 0.0 1.0 0.3
Arm predicted mass (left) 0.2 0.9 2.3 0.3 0.3 -1.5