Hub : Genes

CSRP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2700	0.0480	2.1e-13	0.069	0.140	0.177	0.184	0.184	8.2e-09	1.0e-16	5.4e-21	7.9e-22	6.2e-22
2	GTEx	Artery Aorta	0.1070	0.0450	7.6e-03	-0.005	NA	0.004	NA	-0.005	7.4e-01	NA	2.0e-01	NA	9.6e-01
3	GTEx	Brain Caudate basal ganglia	0.4670	0.0950	1.4e-04	0.275	NA	0.181	NA	0.272	1.6e-08	NA	6.6e-06	NA	1.8e-08
4	GTEx	Brain Nucleus accumbens basal ganglia	0.3960	0.1070	1.4e-03	0.302	NA	0.252	NA	0.287	8.2e-09	NA	2.0e-07	NA	2.3e-08
5	GTEx	Brain Putamen basal ganglia	0.5330	0.1160	4.2e-04	0.336	NA	0.251	NA	0.280	8.5e-09	NA	1.2e-06	NA	2.2e-07
6	GTEx	Colon Sigmoid	0.2320	0.0950	8.0e-03	-0.006	NA	-0.004	NA	0.015	5.8e-01	NA	4.9e-01	NA	9.2e-02
7	GTEx	Esophagus Mucosa	0.1420	0.0490	2.0e-04	0.118	NA	0.082	NA	0.107	3.0e-08	NA	4.0e-06	NA	1.3e-07
8	GTEx	Vagina	0.4310	0.1230	5.1e-03	0.083	NA	-0.008	NA	0.042	6.1e-03	NA	5.4e-01	NA	3.9e-02
9	TCGA	Breast Invasive Carcinoma	0.0195	0.0091	3.7e-05	0.025	0.019	0.014	NA	0.015	6.2e-06	6.3e-05	5.6e-04	NA	3.8e-04
10	TCGA	Esophageal Carcinoma	0.3300	0.1290	5.7e-03	0.169	-0.002	0.088	NA	0.146	4.9e-06	3.7e-01	9.6e-04	NA	2.3e-05
11	TCGA	Brain Lower Grade Glioma	0.1998	0.0552	1.5e-14	0.150	0.148	0.153	NA	0.152	1.2e-16	1.8e-16	5.3e-17	NA	6.6e-17

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.4	2.2	5.3	0.3	-1.6	1.9	2.0	2.1	-0.3	-0.1	-0.3	2.3	0.2	1.8
Bipolar Disorder or Schizophrenia	1.4	3.5	8.6	1.0	-2.6	2.1	2.5	2.9	-0.9	1.0	-1.3	1.8	1.2	1.9
Depressed Affect (Nagel 2018)	0.3	0.7	2.7	-0.7	-0.7	-0.3	-0.4	-0.2	0.9	-1.1	0.4	0.9	-1.7	-0.6
Depression (Nagel 2018)	0.3	0.4	1.5	-0.7	-0.9	-0.3	-0.2	-0.1	1.2	-0.3	0.1	0.0	0.8	-0.7
Intelligence (Savage-Jansen 2018)	0.5	1.5	11.0	-0.1	0.1	0.0	0.5	0.5	3.3	1.1	-1.7	-0.1	0.2	1.1
Neuroticism (Nagel 2018)	0.3	0.7	1.4	-0.8	-0.9	-1.2	-1.1	-0.9	-0.0	-0.3	-0.4	0.4	-0.9	-1.2
Schizophrenia (2018)	0.9	1.9	4.2	1.1	-1.9	1.3	1.6	2.0	-0.9	1.4	-1.4	0.4	1.4	1.3
Schizophrenia vs Biploar Disorder	0.5	0.7	1.3	-1.1	0.2	-1.1	-1.1	-0.9	-1.0	-0.7	-0.5	-0.1	-0.4	-1.0
Worry (Nagel 2018)	0.2	0.5	2.2	-0.4	-1.5	-0.2	-0.3	-0.0	-1.0	-0.1	-0.3	0.9	-1.0	0.0
Alzheimer’s Disease (in mother)	0.3	0.4	1.4	-0.0	-1.0	-0.2	0.1	-0.1	-0.2	1.2	-1.2	-0.0	0.3	0.0
Alzheimer’s Disease (in father)	1.0	1.1	2.7	0.4	-0.3	1.4	1.5	1.5	-0.2	-0.8	-1.6	0.1	0.2	1.4
Alzheimer’s Disease (including proxy)	0.4	0.5	2.3	0.0	-0.9	-0.0	0.4	0.2	-0.0	0.5	-1.5	0.3	1.4	0.3
Crohns Disease (2017)	0.6	1.3	5.3	0.8	-2.3	1.0	0.8	0.7	-0.1	0.3	2.1	1.3	0.2	-0.2
Irritable Bowel Disease (IBD)	0.7	1.7	5.0	1.8	-2.2	1.2	1.3	1.3	-0.2	0.6	1.2	1.6	1.0	0.9
Ulcerative Colitis (UC)	1.0	1.8	6.3	2.5	-1.8	0.8	1.1	1.4	-0.6	1.1	-0.7	1.0	1.3	1.5
Major Depression (MDD)	0.3	0.3	1.2	-0.2	0.8	0.1	0.2	0.3	1.1	0.6	-0.8	-0.4	0.4	0.6
Reaction Time	0.2	0.4	1.4	-0.2	0.8	0.0	-0.3	-0.2	-1.1	1.1	0.1	-0.3	1.2	0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	6.7	0.3	-1.0	0.9	0.9	0.7	2.6	0.3	0.1	1.0	0.3	1.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.4	1.8	4.2	0.2	-2.0	1.2	1.4	1.6	0.8	-1.5	-0.4	2.0	-0.9	1.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.6	0.8	2.3	-1.0	0.2	-0.9	-1.1	-1.3	-1.1	-1.5	-0.2	-0.2	-0.6	-0.8
Bipolar Disorder (2011)	0.8	0.7	6.1	-0.2	-0.3	0.9	0.1	0.3	-0.9	0.0	2.5	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	2.5	-0.6	-0.1	0.7	0.3	0.3	0.1	-1.6	0.3	1.2	-0.7	0.2
Coronary Artery Disease (CAD)	0.7	0.9	4.9	2.2	-1.4	0.4	0.4	0.6	-0.4	1.0	0.1	0.3	0.0	0.9
Crohns Disease (2012)	0.6	0.9	3.1	0.3	-1.7	0.5	0.6	0.4	0.3	0.3	1.4	1.0	1.6	-0.4
Mean Putamen Volume	1.4	1.5	4.7	-0.4	-1.2	1.1	1.8	1.6	0.2	-1.3	-0.6	2.2	-0.2	1.3
Fasting Glucose	0.5	0.6	1.5	-0.3	0.8	-1.2	-0.8	-0.8	-0.8	-0.5	-1.2	-0.6	-0.0	-0.0
HbA1C	1.4	1.6	4.8	-1.1	1.0	-1.3	-1.8	-1.2	0.4	-2.2	1.1	0.1	-0.1	-1.6
HDL Cholesterol	0.6	1.1	2.3	-1.5	0.8	-1.5	-1.2	-1.0	0.0	-0.6	-0.8	-1.2	-1.1	-0.8
LDL Cholesterol	1.1	1.8	8.7	1.8	-0.3	1.3	0.6	0.8	0.5	0.9	1.9	0.1	3.0	0.1
Lupus	2.6	4.0	8.1	1.7	-2.4	2.8	2.6	2.7	1.4	-0.1	0.6	2.5	0.5	2.1
Neuroticism (2016)	1.0	1.5	2.7	-1.6	-0.0	-1.6	-1.4	-1.4	-1.4	0.8	-1.3	-1.0	-0.7	-1.2
Primary Biliary Cirrhosis	0.5	0.8	3.5	-0.6	-0.5	1.2	0.9	1.1	-0.0	0.1	1.9	0.7	-0.6	0.2
Rheumatoid Arthritis	3.0	4.1	8.2	2.2	-2.5	2.5	2.8	2.9	-0.1	0.7	0.3	2.6	-0.4	2.0
Schizophrenia (2014)	1.0	2.3	4.8	0.8	-2.0	1.8	1.8	2.2	-1.4	0.7	-0.8	1.0	1.8	1.4
Triglycerides	0.6	0.9	4.4	-0.2	-0.8	1.1	0.7	1.0	0.1	-0.7	0.8	2.1	0.8	0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.9	-0.7	-0.5	-0.2	-0.1	-0.1	0.5	0.6	-0.2	-0.6	1.0	-0.7
Ulcerative Colitis	0.3	0.4	1.4	1.1	-0.6	-0.6	-0.2	-0.2	-0.3	0.9	-0.6	-0.3	1.2	-0.0
Blood Eosinophil Count	0.1	0.9	6.3	0.0	-0.3	0.2	0.4	0.6	0.2	2.5	-0.1	-0.4	1.8	0.2
Blood Platelet Count	0.1	0.9	5.0	0.8	0.7	0.3	0.2	0.4	-1.5	0.6	-2.2	-0.4	-0.9	0.6
Blood Red Count	0.1	0.8	2.4	0.8	-1.6	0.5	0.7	0.7	0.7	1.2	-0.4	1.4	0.3	0.8
Blood White Count	0.3	2.3	8.8	2.1	-0.8	1.6	1.0	1.2	-3.0	2.1	0.3	-0.1	1.2	0.7
Heel T-Score	0.2	1.6	10.5	-1.6	1.9	-0.3	-0.9	-0.6	-3.2	-0.2	-0.2	-0.1	0.0	0.1
BMI	0.1	0.5	1.8	0.6	-0.5	0.2	0.6	0.2	-0.8	-0.1	-1.4	1.0	-0.9	0.6
Height	0.6	12.4	79.7	-3.9	-3.0	0.2	0.3	0.4	8.9	-3.5	2.3	3.3	-1.4	-1.3
Waist Hip Ratio (WHR)	0.3	1.1	5.9	-0.7	-1.3	0.0	-0.2	0.2	-0.4	1.8	-0.5	0.1	2.4	-0.8
Systolic Blood Pressure	0.1	0.3	1.1	0.8	-0.2	0.0	0.3	0.2	0.4	-1.1	0.3	0.5	-0.9	0.4
Smoking Status	0.3	0.7	3.6	-0.2	-1.9	0.5	0.7	0.6	-0.1	-1.2	0.4	0.8	0.6	-0.6
Allergy or Eczema	1.2	3.2	13.1	0.6	-2.6	1.5	1.6	1.9	-0.2	-0.4	-0.9	3.6	-0.1	2.3
Cardiovascular Disease	0.3	0.9	5.3	2.3	0.0	0.2	0.4	0.4	-0.8	0.7	-1.0	-1.1	1.2	0.0
Hypothyroidism (self reported)	0.5	1.2	5.6	-0.5	-2.4	0.7	0.6	0.2	-1.1	-0.2	1.7	1.2	0.6	-0.6
Respiratory disease	0.5	1.0	6.4	0.1	-0.6	-0.5	-0.2	0.1	-0.7	-0.7	-1.2	2.5	0.8	1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.8	0.4	-1.1	0.5	0.4	0.7	-1.7	0.2	-0.9	0.9	1.1	0.3
Lung FEV1/FVC ratio	0.4	2.1	11.1	0.1	0.5	0.9	1.1	0.7	0.7	2.1	-0.5	-2.0	3.3	0.5
Lung FVC	0.2	0.9	6.2	0.1	0.9	0.6	0.0	0.3	1.5	0.1	2.5	-0.2	-0.1	-0.0
Neuroticism	0.7	1.6	3.8	-1.1	-0.6	-1.5	-1.8	-1.4	-0.5	-1.1	0.7	0.7	-1.5	-2.0
Chronotype (morning person)	0.3	0.8	2.1	-1.5	-0.0	-0.5	-0.6	-0.4	-0.8	-0.8	1.4	1.1	-0.8	-0.8
Hair Pigment	0.1	1.5	5.6	-0.4	-1.1	0.7	1.2	1.2	-1.6	0.8	-2.4	0.5	0.6	1.5
Tanning	0.2	1.8	3.8	-1.9	1.9	-1.4	-1.4	-1.5	-0.1	0.9	-0.3	-1.8	-1.1	-1.3
Hand grip strength (left)	0.9	2.4	11.5	-2.0	-0.0	0.0	0.2	0.1	0.9	-3.4	0.3	1.3	-2.9	0.1
Number of treatments/medications taken	0.3	0.6	1.3	1.1	-0.5	0.8	0.7	0.9	-1.1	0.0	-0.3	0.5	0.7	0.6
Average weekly spirits intake	0.3	0.3	2.1	0.5	0.1	-0.2	-0.4	-0.4	0.6	0.4	0.5	-0.2	-1.4	-0.1
Sensitivity / hurt feelings	0.2	0.4	1.2	0.9	-1.1	-0.0	-0.1	0.5	0.2	-0.5	0.3	0.7	0.9	-0.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.5	-0.7	0.2	-0.8	-0.6	-0.4	1.6	0.3	-1.2	-0.6	1.0	-0.5
Hearing difficulty/problems: Yes	0.8	1.2	4.5	-0.2	-1.6	-1.0	-0.8	-0.6	-0.8	-1.3	-0.0	2.1	-0.3	-1.5
Relative age of first facial hair	0.5	1.0	3.7	-1.2	-0.8	0.4	0.7	0.8	1.9	-0.1	-0.9	0.9	-1.1	0.7
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	4.9	-0.4	-0.6	1.1	1.0	1.1	2.2	0.5	-0.6	0.5	1.1	1.2
Ever used hormone-replacement therapy (HRT)	1.6	2.1	6.4	0.7	-2.0	1.1	1.5	1.3	-1.1	0.2	-1.1	1.5	2.5	1.3
Ever had hysterectomy (womb removed)	0.5	0.6	3.4	-0.6	-0.2	-0.6	-0.9	-0.6	-1.8	-0.2	-0.1	0.1	-0.9	-0.3
Systolic blood pressure, automated reading	0.3	1.0	2.6	1.6	-1.1	0.9	1.3	1.1	-0.8	0.0	-0.3	1.3	0.1	1.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	4.6	0.9	-0.1	1.0	0.8	0.6	-2.1	0.6	2.0	-0.2	-0.2	0.1
Angina	1.0	1.3	2.8	1.3	-0.4	1.6	1.5	1.7	0.7	-1.3	-0.2	0.8	-0.6	1.4
Medication for hormone replacement therapy	0.8	0.9	2.4	-1.2	0.9	-0.7	-0.8	-0.8	-0.7	-0.8	-0.1	-1.6	1.1	-0.9
Vitamin and mineral supplements	2.7	3.7	7.5	2.4	-2.5	2.3	2.4	2.1	0.2	1.3	0.9	1.2	2.7	1.5
Supplements: Zinc	0.6	0.6	2.2	-0.7	0.4	-0.5	-0.4	-0.5	0.8	1.5	-0.4	-0.9	1.0	-0.8
Medication: Co-codamol	0.8	0.9	1.8	-1.0	1.1	-1.3	-0.8	-1.0	-0.9	0.8	-1.3	-1.0	-0.6	-0.5
Medication: Metformin	1.4	2.0	6.8	0.3	-0.6	1.9	1.5	1.7	-2.6	0.5	0.2	0.2	2.1	1.0
Diabetes (father)	0.8	0.9	5.0	-0.3	-1.8	0.2	0.4	0.1	-2.2	0.4	0.6	0.5	-0.9	-0.4
Diabetes (mother)	0.4	0.5	3.0	0.4	0.1	-0.3	-0.6	-0.2	-1.7	-0.9	0.6	0.5	-0.2	-0.2
Severe depression (siblings)	1.2	1.3	7.3	-0.0	0.0	0.0	0.1	-0.1	-0.2	2.7	-0.9	0.7	2.3	0.7
Pack years adult smoking proportion	0.2	0.4	1.1	0.7	0.4	1.0	1.0	0.8	0.6	-0.4	-0.0	-0.1	0.3	0.4
Impedance of leg (right)	0.2	1.0	5.3	0.8	-0.8	1.1	0.6	0.9	-0.5	0.6	2.3	0.7	0.9	0.1
Leg fat-free mass (left)	0.5	2.7	9.0	-2.3	-0.0	-1.1	-0.5	-0.8	3.0	-2.1	-1.3	0.7	-2.4	-0.7
Trunk fat percentage	0.2	1.0	1.9	1.1	-0.9	1.1	1.3	1.2	0.7	-0.2	-0.4	1.4	-1.1	0.9
Hand grip strength (right)	1.0	2.8	11.8	-2.1	0.1	-0.6	-0.6	-0.5	0.7	-3.3	0.6	1.3	-3.4	-0.3
Townsend deprivation index at recruitment	0.3	0.5	1.5	0.2	0.9	0.7	0.2	0.4	-0.6	-0.5	1.2	0.1	1.2	-0.0
Current tobacco smoking	0.4	0.6	2.4	1.2	-1.6	0.3	0.7	0.5	-1.0	-0.2	0.5	0.4	0.4	-0.3
Average weekly fortified wine intake	1.9	2.2	5.6	0.5	-2.0	1.3	1.5	1.6	-0.1	0.7	-1.5	2.4	0.3	2.2
Maternal smoking around birth	0.9	1.3	4.3	0.3	-2.1	0.8	1.3	1.4	-0.1	1.2	0.9	0.6	1.9	0.1
Fed-up feelings	0.4	0.8	1.8	0.2	-0.8	1.3	0.9	1.2	-0.4	-0.2	1.3	0.4	-1.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.7	-0.4	-0.6	0.5	0.5	0.6	1.6	-0.3	-0.0	-0.5	1.5	-0.6
Relative age voice broke	0.6	0.9	2.1	0.1	0.2	0.7	0.7	0.8	1.3	0.1	-1.3	0.9	-1.4	1.4
Taking other prescription medications	1.1	1.7	5.3	-0.2	-1.9	1.0	1.0	1.3	-0.7	1.1	-0.7	1.5	2.3	1.2
Age when periods started (menarche)	0.5	1.1	3.4	0.6	-1.2	0.7	1.0	0.9	-1.8	-0.9	-0.4	1.7	0.8	0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.5	-0.6	-0.8	-1.0	-0.4	-0.4	-0.4	0.7	-1.0	0.0	1.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	5.0	-0.1	0.7	0.5	0.2	-0.1	-2.2	0.9	0.4	-1.6	1.0	-0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.3	-1.2	-0.3	0.0	0.1	0.2	0.1	-1.0	-0.5	0.6	0.3	0.2
Qualifications: CSEs or equivalent	1.1	1.5	3.4	-1.8	1.4	-0.5	-1.2	-0.9	-1.5	-0.7	1.4	-0.8	-0.6	-1.8
Serious illness, injury or assault to yourself	0.5	0.6	2.9	0.1	0.5	-0.0	-0.1	-0.2	0.6	0.5	1.7	-1.4	-0.2	-0.8
High blood pressure	0.6	1.6	8.1	2.8	-1.0	0.6	1.1	1.1	-0.8	1.0	-1.8	-0.4	0.5	0.9
Hayfever, allergic rhinitis or eczema	0.9	1.9	8.4	0.4	-1.9	1.2	1.3	1.4	-0.3	-0.1	-0.4	2.9	0.6	1.9
Multivitamins +/- minerals	3.0	3.8	7.3	-1.6	2.7	-2.2	-2.2	-1.9	-1.3	-0.6	-1.7	-2.2	-2.5	-1.7
Stomach or abdominal pain in last month	0.6	0.7	1.8	1.3	-0.8	0.8	0.7	0.7	-1.3	-0.9	-0.1	0.7	0.7	0.3
Supplements: Glucosamine	1.1	1.4	3.9	-2.0	0.6	-1.2	-0.6	-0.8	-1.7	-0.6	-1.4	-1.7	0.2	-0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	2.0	-0.3	1.3	-0.5	-0.6	-0.7	1.4	0.0	0.1	-0.9	0.6	-0.0
Medication: Atenolol	0.4	0.6	1.6	-0.3	0.9	0.1	0.3	0.5	0.9	-0.9	-1.2	-0.6	-1.0	0.6
Medication: Levothyroxine sodium	1.2	2.0	4.8	0.3	-2.2	1.6	1.6	1.2	-0.9	0.2	2.0	2.1	0.8	0.8
Sitting height	0.6	4.0	15.5	-3.4	0.5	-0.8	-0.9	-0.7	3.9	-2.9	0.4	1.1	-1.6	-1.4
Chronic bronchitis/emphysema (father)	0.9	1.0	4.5	2.1	-1.1	0.8	0.5	0.3	1.4	0.2	1.2	-0.4	-0.9	0.2
High blood pressure (mother)	0.5	0.7	1.8	-1.0	0.6	-0.6	-0.6	-0.3	-0.0	-0.9	-1.1	1.1	-1.4	-0.3
Body mass index (BMI)	0.1	0.6	2.4	0.5	-0.3	-0.2	0.2	-0.1	-0.0	-0.6	-1.5	0.6	-1.6	0.3
Impedance of leg (left)	0.4	1.7	7.2	1.4	-1.0	1.7	0.9	1.3	-0.6	0.7	2.7	1.3	1.0	0.4
Leg predicted mass (left)	0.5	2.6	8.7	-2.2	-0.1	-1.1	-0.4	-0.7	3.0	-2.1	-1.3	0.7	-2.5	-0.7
Trunk fat mass	0.2	0.9	2.8	0.1	-0.7	0.5	0.8	0.6	1.4	-0.9	-0.6	1.5	-1.7	0.4
Waist circumference	0.2	0.8	3.8	-1.0	-0.4	-0.6	-0.3	-0.5	1.9	-0.4	-1.2	0.7	-0.8	-0.5
Number of incorrect matches in round	0.5	0.8	6.0	1.0	-1.2	-0.2	0.1	0.2	0.6	-0.0	-0.4	2.5	0.1	0.4
Past tobacco smoking	1.1	2.0	4.9	-0.9	1.9	-2.2	-2.1	-2.1	-0.4	0.3	-0.8	-1.1	-1.4	-0.9
Alcohol usually taken with meals	0.8	1.3	6.9	-0.1	-0.2	0.8	1.3	0.9	0.6	2.6	-0.9	-0.2	1.2	1.1
Nervous feelings	0.2	0.4	1.2	-0.4	-0.2	-0.9	-0.8	-0.9	-0.2	-0.1	-0.3	-0.3	-1.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.9	-0.2	-0.4	-0.0	-0.4	-0.5	1.3	-1.4	1.3	0.2	0.3	-0.8
Hearing difficulty/problems with background noise	0.7	1.2	4.5	0.1	-1.3	0.2	0.3	0.7	0.2	-1.5	-1.9	2.1	-0.6	0.1
Hair/balding pattern: Pattern 2	0.4	0.6	2.3	1.3	-0.9	0.4	0.2	0.0	-0.8	-0.5	1.5	-0.2	0.2	-0.1
Had menopause	3.3	4.1	11.4	2.3	-1.8	2.2	2.7	2.7	-0.3	0.6	-1.0	2.0	0.7	3.4
Had other major operations	1.0	1.2	4.3	1.8	-0.7	0.4	1.0	0.7	-0.6	-0.5	-2.1	0.6	-0.7	1.3
Forced vital capacity (FVC)	0.8	2.9	11.9	-1.8	0.3	0.3	-0.1	0.1	3.5	-1.1	3.2	0.8	-2.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	7.0	0.4	0.3	1.4	0.9	0.7	-2.6	0.6	0.2	-0.7	0.8	0.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.6	-0.0	1.3	-0.4	-0.2	-0.2	0.2	1.1	-0.7	-0.0	0.5	-0.1
Qualifications: None of the above	0.3	0.7	3.0	0.2	0.4	-1.0	-0.9	-0.9	-0.4	-1.7	0.8	0.4	-0.9	-0.7
Financial difficulties in last 2 years	0.4	0.6	1.6	-0.4	0.5	-1.3	-1.1	-1.1	-0.8	-0.3	-0.7	-0.6	0.2	-0.7
Mouth/teeth dental problems	0.3	0.5	1.8	-0.0	-0.4	-0.0	0.2	0.2	-1.3	-0.6	0.4	1.1	1.1	-0.4
Heart attack	0.5	0.6	2.5	0.8	0.3	0.1	-0.5	-0.4	-0.7	-0.3	1.6	-1.1	-0.1	-1.1
Allergy	0.4	0.9	4.9	-0.2	1.7	-0.1	-0.2	-0.3	0.7	0.1	0.3	-2.2	-0.8	-0.6
Pain all over the body in last month	3.0	3.2	7.4	-2.7	2.5	-1.6	-1.8	-1.8	-0.9	-1.5	0.6	-1.3	-2.0	-1.8
Diabetes (self-reported)	0.2	0.3	1.3	-0.0	-0.5	0.7	0.2	0.4	-1.0	0.3	0.2	0.4	1.1	-0.2
Hayfever/allergic rhinitis (self-reported)	2.1	2.7	7.4	1.3	-2.0	1.6	1.9	1.6	1.3	1.0	0.5	1.6	2.7	1.6
Medication: Ramipril	0.5	0.6	2.9	1.7	-0.1	0.5	0.5	0.5	-0.4	1.2	-0.4	-0.3	0.9	0.4
Medication: Simvastatin	0.2	0.3	2.1	0.5	-0.2	-0.0	-0.1	-0.0	-1.4	0.5	-0.2	-0.2	0.9	-0.3
Fluid intelligence score	0.8	1.6	5.3	0.9	-1.7	1.3	1.2	1.1	2.3	0.9	-0.4	1.2	0.0	1.2
Illnesses of siblings	0.8	1.1	2.9	-0.7	0.7	-0.2	-0.5	-0.7	1.5	-1.7	1.0	-0.9	-1.6	-1.0
Neuroticism score	0.4	0.8	4.1	-0.3	-0.9	-0.5	-0.8	-0.4	0.0	-1.0	0.9	1.0	-2.0	-0.7
Weight	0.4	2.2	8.0	-1.5	-0.6	-0.7	-0.1	-0.4	2.8	-2.0	-0.9	1.6	-2.4	-0.3
Impedance of arm (right)	0.5	2.3	4.9	1.7	-0.5	2.2	1.8	2.1	1.1	1.8	1.4	-0.6	1.6	0.8
Arm fat percentage (right)	0.1	0.6	1.5	1.2	-0.6	0.6	0.8	0.6	0.7	0.0	-0.9	0.3	-1.1	0.4
Trunk fat-free mass	0.8	4.5	12.9	-3.2	-0.3	-1.7	-1.2	-1.4	3.6	-3.1	-0.3	1.6	-2.6	-1.4
Hip circumference	0.3	1.4	7.6	-0.8	-0.4	-0.2	0.2	-0.0	2.7	-1.5	-0.3	1.2	-1.9	-0.1
Time employed in main current job	0.5	0.5	1.9	0.3	0.4	0.7	0.5	0.6	-0.2	-0.8	1.4	1.0	-1.0	0.6
Alcohol intake versus 10 years previously	0.6	1.0	1.9	0.2	0.7	-1.1	-1.4	-1.3	-0.5	0.5	-0.8	-1.1	1.2	-1.2
Father’s age at death	1.0	1.3	3.0	-0.7	-1.0	1.5	1.1	1.0	1.7	-0.2	0.2	1.5	-0.0	1.7
Worrier / anxious feelings	0.5	1.0	7.1	-0.4	-1.5	-0.1	0.0	0.3	-0.0	0.1	-0.3	0.9	-2.7	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	-0.7	0.9	-0.6	-0.6	-0.7	-0.1	0.2	-0.4	-0.2	0.4	-0.8
Falls in the last year	0.9	1.2	2.5	-1.6	0.1	-1.3	-1.4	-1.4	-0.3	-1.1	0.3	0.2	-0.7	-1.6
Hair/balding pattern: Pattern 3	0.6	0.9	3.2	-0.3	0.8	0.0	0.2	0.4	-0.4	-1.1	-1.5	1.8	0.5	1.5
Number of live births	0.2	0.3	2.0	0.4	-1.4	-0.0	0.2	-0.1	0.4	1.0	-0.1	-0.3	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	7.9	-2.4	0.7	-0.4	-0.7	-0.5	2.8	-0.7	2.0	0.0	-1.1	-1.2
Pulse rate	1.2	2.1	12.6	0.7	-0.7	1.3	1.4	1.0	-1.0	3.5	0.3	0.0	1.0	1.6
Happiness	0.5	0.6	1.4	-0.6	1.2	0.3	0.4	0.4	1.2	0.9	-0.4	-0.5	1.0	0.8
Noisy workplace	0.5	0.6	2.2	1.2	-0.8	0.0	0.3	0.0	-1.3	0.1	-1.5	0.5	0.3	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.7	0.2	0.4	0.9	0.9	1.0	1.3	0.4	-0.6	-0.8	0.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	4.7	-0.4	0.6	-0.0	0.1	0.1	-0.0	-0.2	-2.2	0.7	0.1	0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.7	0.0	-0.7	-0.7	-0.7	0.1	0.7	-0.2	-0.1	-0.9	-0.3
Asthma	0.3	0.5	1.2	-0.5	-0.8	-1.1	-1.1	-0.9	-0.3	0.0	0.1	0.8	0.8	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	3.1	-0.5	0.8	0.2	0.2	0.2	0.4	-1.2	-0.1	0.1	-1.8	0.4
Medication: Cholesterol lowering	0.3	0.4	2.8	0.4	0.2	0.2	-0.2	-0.2	-0.9	0.7	-0.0	-0.6	1.7	0.2
Depression (self-reported)	0.4	0.4	1.5	-0.5	-1.1	0.1	0.1	0.4	-0.6	0.6	-1.2	0.8	0.3	0.4
Medication: Lansoprazole	1.9	2.1	4.4	1.9	-1.7	1.9	2.1	2.0	0.5	0.5	-1.2	0.3	0.7	1.5
Prospective memory result	0.7	0.8	2.2	-1.4	0.6	0.2	-0.4	0.1	-0.6	-1.5	1.1	1.0	-1.2	-0.2
Lung cancer (father)	1.2	1.5	3.9	1.2	-0.6	0.4	0.9	0.9	-1.0	1.6	-1.9	0.3	2.0	1.2
Illnesses of mother	0.1	0.1	0.6	-0.2	0.5	-0.1	-0.2	-0.0	0.8	0.4	-0.3	-0.4	0.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	12.5	-2.2	1.1	-0.2	-0.4	-0.3	3.5	-1.0	1.7	-0.2	-0.5	-0.7
Pulse wave Arterial Stiffness index	0.9	1.0	2.8	0.1	0.8	-1.7	-1.2	-1.3	-0.1	0.8	-1.6	-0.7	-0.2	-0.8
Impedance of arm (left)	0.4	1.7	3.1	1.3	-0.5	1.7	1.3	1.7	1.2	1.8	1.5	-0.5	1.4	0.6
Arm fat mass (right)	0.1	0.6	2.5	-0.0	-0.4	-0.1	0.2	-0.0	1.2	-0.9	-0.9	0.8	-1.6	-0.1
Trunk predicted mass	0.8	4.6	12.7	-3.2	-0.3	-1.7	-1.2	-1.4	3.6	-3.1	-0.4	1.6	-2.6	-1.4
Standing height	0.8	7.6	39.2	-4.3	-1.0	-0.9	-0.6	-0.4	6.3	-3.1	1.2	2.5	-2.0	-1.5
Length of working week for main job	0.8	0.8	4.7	-0.8	-0.4	0.4	0.1	0.1	0.6	-2.2	1.6	0.4	-0.5	-0.4
Exposure to tobacco smoke at home	0.7	0.8	2.3	-0.3	0.7	-1.4	-1.0	-1.0	-1.5	0.7	-0.8	-0.5	-0.6	-0.1
Breastfed as a baby	1.2	1.5	2.6	-1.5	-0.7	-1.6	-1.3	-1.3	-1.4	0.1	-1.3	1.4	1.3	-0.8
Tense / ‘highly strung’	0.3	0.6	2.1	-0.4	-1.0	0.0	-0.5	-0.1	0.8	-1.4	0.5	1.2	0.3	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.0	-0.6	-1.1	-0.4	-0.6	0.1	0.0	-0.0	-0.8	1.4	-0.7	-0.4
Hair/balding pattern: Pattern 4	0.3	0.6	1.5	0.1	-1.2	0.6	0.9	0.9	0.7	0.4	-1.2	0.2	-0.9	0.5
Birth weight of first child	0.7	1.3	5.1	-0.9	-2.3	-0.1	-0.2	-0.1	2.0	-0.6	-0.9	1.9	0.3	0.0
Peak expiratory flow (PEF)	0.4	1.0	7.4	-2.7	0.1	-0.4	-0.1	-0.3	1.2	-1.0	0.0	-0.6	0.1	-0.8
Pulse wave reflection index	1.1	1.3	2.4	-0.2	1.4	-1.3	-1.2	-1.1	1.6	-1.3	-0.7	-1.0	-0.9	-1.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	-0.1	0.7	-0.7	-0.7	-0.4	0.9	0.3	-0.9	-0.1	0.7	0.2
Loud music exposure frequency	2.4	2.6	7.3	1.1	-1.6	1.7	1.9	1.9	-1.5	1.6	-0.2	0.9	2.7	1.4
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.9	1.6	-1.6	1.1	1.2	1.4	1.6	2.2	-1.1	0.8	2.1	1.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.7	-0.9	1.0	-0.8	-0.9	-0.9	0.5	-1.3	-0.5	-0.9	-0.6	-0.5
Blood clot in the leg (DVT)	0.1	0.1	0.4	-0.3	0.0	-0.4	-0.4	-0.3	-0.2	0.4	-0.2	-0.3	-0.3	-0.6
Medication: Paracetamol	0.2	0.3	2.1	-0.5	-0.1	-0.1	-0.5	-0.4	-0.4	-1.4	-0.1	0.1	0.1	-0.6
Headache pain in last month	1.1	1.9	3.6	-1.8	1.4	-1.1	-1.3	-1.4	-1.5	-0.2	0.5	-1.8	-1.9	-0.8
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	7.3	-2.2	0.2	-0.8	-0.6	-0.3	2.4	-1.6	-0.1	1.7	-2.7	-0.3
Glaucoma (self-reported)	0.6	0.7	3.0	-0.3	-0.7	-0.5	-0.1	-0.2	-0.8	0.9	-1.7	1.2	0.9	0.2
Gout (self-reported)	2.3	3.1	7.3	2.7	-1.9	2.3	2.3	2.1	1.0	2.1	0.1	0.8	0.7	1.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.6	-0.7	-1.9	0.6	0.6	0.3	-1.0	-1.1	1.3	1.7	0.6	-0.1
Medication: Amlodipine	0.4	0.6	2.2	1.5	-0.2	0.7	0.5	0.8	-0.3	0.0	-0.4	0.5	-1.4	0.7
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.6	-0.9	0.6	-1.6	-1.4	-1.4	-1.6	1.9	-0.3	-0.8	0.8	-1.0
Birth weight	0.2	0.5	2.4	0.5	-1.5	-0.2	0.3	0.1	0.5	-0.1	-1.6	0.2	0.6	0.3
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.2	0.8	-1.1	1.4	1.2	1.5	0.7	0.4	1.3	1.1	0.1	0.2
High blood pressure (siblings)	0.5	0.7	2.3	-0.1	-0.9	-0.4	-0.0	0.0	-1.4	1.5	-1.4	0.5	0.4	0.3
Forced vital capacity (FVC), Best measure	0.8	3.0	17.9	-1.8	0.7	0.2	-0.2	-0.1	4.2	-1.3	2.8	0.7	-1.1	-0.6
Body fat percentage	0.2	0.8	1.7	1.3	-0.9	0.9	1.2	1.0	0.4	0.1	-0.6	1.0	-1.1	0.9
Leg fat percentage (right)	0.2	0.6	2.2	1.5	-0.8	0.4	0.7	0.4	-0.5	-0.1	-0.8	0.7	-1.0	0.8
Arm fat-free mass (right)	0.8	4.3	10.2	-3.1	-0.3	-1.9	-1.2	-1.4	2.5	-3.2	-0.6	1.8	-3.0	-1.2
Exposure to tobacco smoke outside home	0.7	0.9	2.5	-0.4	0.6	-1.3	-1.5	-1.6	-0.2	0.4	-0.4	0.0	1.1	-1.2
Comparative body size at age 10	0.5	1.3	2.5	-0.9	1.6	-1.2	-1.3	-1.5	-0.9	-0.9	1.0	-1.2	-1.2	-0.6
Number of full brothers	1.3	1.6	3.2	-1.3	0.7	-1.5	-1.4	-1.3	0.9	1.1	-1.8	-0.9	1.3	-1.2
Worry too long after embarrassment	1.8	3.0	7.2	-2.2	-0.3	-2.7	-2.6	-2.3	-1.1	0.3	-1.5	-0.2	-0.4	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	4.2	-0.0	-0.7	-0.0	0.0	-0.1	0.8	0.4	-1.3	0.8	2.0	-0.4
Wheeze or whistling in the chest in last year	1.3	2.3	5.2	-1.0	0.1	-2.3	-2.2	-2.2	-1.4	-1.7	-0.9	0.7	-0.6	-1.6
Number of children fathered	0.8	0.9	1.9	-0.8	0.8	-0.8	-1.1	-1.0	-1.0	1.0	0.5	-1.1	-1.4	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.2	1.0	-0.7	1.5	1.5	1.4	-0.9	-0.7	0.3	1.4	-0.3	1.2
Age at first live birth	0.3	0.5	1.7	1.0	-0.1	0.6	0.2	0.1	-1.3	0.5	0.8	-1.0	-0.9	-0.3
Pulse wave peak to peak time	1.1	1.3	3.9	-0.4	-0.9	1.7	1.2	1.3	0.6	-1.1	2.0	1.0	-0.1	0.7
Health satisfaction	0.8	1.0	2.5	0.5	-0.2	1.2	1.3	1.4	0.3	1.5	-0.5	0.9	0.5	1.6
Shortness of breath walking on level ground	1.0	1.2	2.7	-1.5	1.0	-1.0	-1.1	-1.1	1.1	-0.2	0.2	-0.3	-1.5	-1.6
Qualifications: College or University degree	0.3	0.8	3.5	-1.5	1.3	-0.3	-0.5	-0.6	0.1	0.7	-0.4	-1.9	-0.5	-0.3
Eye problems/disorders: None of the above	0.4	0.5	2.4	1.0	0.4	-0.0	-0.2	-0.1	-0.4	-0.8	-0.4	-1.6	-0.2	-0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.4	-0.3	0.1	0.4	1.2	0.7	0.4	0.9	-1.5	-1.0	-2.1	1.3
Emphysema/chronic bronchitis	0.7	0.8	2.2	0.5	-1.3	0.6	0.7	0.4	-0.2	-1.5	0.8	1.5	-0.0	0.7
Medication for pain relief, constipation, heartburn	0.6	1.1	2.4	-0.7	-0.7	-1.4	-1.0	-1.3	-1.5	1.5	0.2	-0.4	0.2	-1.1
Neck or shoulder pain in last month	0.3	0.4	1.0	0.9	-0.5	-0.8	-0.6	-0.9	0.0	-1.0	-0.5	-0.1	-0.2	-0.7
Medication: Blood pressure	1.1	1.9	8.1	2.8	-0.1	1.1	0.9	0.8	-1.9	1.1	0.5	-1.4	1.4	0.9
Angina (self-reported)	1.0	1.3	2.5	1.2	-0.4	1.6	1.4	1.6	0.9	-1.4	0.1	0.8	-0.7	1.3
Migraine (self-reported)	2.3	2.9	6.4	-1.7	1.8	-2.1	-2.2	-2.4	-0.1	0.0	-0.3	-2.5	0.2	-1.9
Medication: Ibuprofen	0.5	0.6	3.2	-0.4	0.6	-0.1	-0.1	-0.2	-0.2	-1.5	-0.1	0.7	-1.8	0.4
Medication: Allopurinol	2.0	2.7	5.8	1.8	-1.9	2.4	2.1	2.1	1.1	2.1	0.2	0.3	0.7	1.3
Medication: Omeprazole	1.7	2.0	7.6	1.3	-0.5	1.5	1.1	1.0	2.8	0.6	2.0	-0.7	1.7	0.3
Medication: Seretide 50 evohaler	0.9	1.1	2.0	-0.9	0.4	-1.4	-1.4	-1.3	-0.7	-0.4	-1.4	-0.4	-1.3	-0.9
Mean time to correctly identify matches	0.5	0.9	4.0	-0.2	0.3	0.3	0.1	-0.0	-1.5	1.4	-0.7	0.0	2.0	0.9
Heart disease (mother)	0.2	0.2	0.8	0.2	-0.5	-0.1	-0.3	-0.4	-0.6	0.2	0.9	-0.3	0.3	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.8	-0.8	-0.3	0.1	-0.3	-0.1	1.7	-0.8	-0.4	1.2	-1.4	0.4
Whole body fat mass	0.2	0.8	2.6	0.3	-0.7	0.4	0.7	0.5	1.3	-0.7	-0.8	1.3	-1.6	0.4
Leg fat mass (right)	0.1	0.5	2.0	0.6	-0.6	0.1	0.5	0.1	0.7	-0.4	-1.0	0.8	-1.4	0.4
Arm predicted mass (right)	0.8	3.9	9.0	-3.0	-0.2	-1.8	-1.2	-1.4	2.4	-2.9	-0.6	1.7	-2.8	-1.3
Pulse rate, automated reading	1.2	3.8	7.6	1.1	-1.9	2.8	2.7	2.3	-2.2	1.8	0.5	0.6	1.7	2.4
Alcohol intake frequency.	0.6	1.3	5.2	1.6	-0.1	-0.6	-0.2	-0.7	-2.3	0.5	-1.3	0.0	2.0	-0.3
Comparative height size at age 10	0.5	2.8	15.8	-1.5	-2.0	-0.6	-0.1	-0.2	4.0	-1.2	1.0	1.7	-1.3	-0.8
Number of full sisters	1.3	1.6	3.8	-0.9	1.7	-1.1	-1.7	-1.7	-0.2	-0.4	1.1	-0.9	-0.9	-2.0
Suffer from ‘nerves’	0.5	0.8	3.6	1.9	-0.5	0.2	0.4	0.5	0.1	0.4	-0.3	0.3	-1.8	0.9
Overall health rating	0.3	0.6	1.6	0.1	-0.4	1.0	1.3	1.1	0.4	-1.1	0.0	0.9	0.0	0.7
Chest pain or discomfort	1.2	1.7	10.4	-0.5	1.4	-0.8	-0.8	-0.6	1.2	-3.2	0.0	0.7	-1.6	-0.7
Had major operations	1.3	1.6	5.7	-1.5	-1.0	-0.9	-1.0	-0.7	2.0	-0.5	-0.2	2.4	-1.1	-0.6
Age at last live birth	0.5	0.7	2.8	0.0	0.1	-0.2	-0.7	-0.5	0.2	1.7	0.3	-1.3	1.3	-1.1
Family relationship satisfaction	0.7	0.8	2.2	-0.7	1.5	-0.3	-0.6	-0.4	-0.1	0.6	-1.4	-1.3	1.3	-0.1
Leg pain on walking	0.8	1.0	2.5	-0.5	0.5	-1.2	-1.3	-1.6	0.4	-0.3	1.5	0.6	-1.0	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	2.2	1.5	-0.4	0.8	0.8	0.7	-0.9	-0.6	0.4	-0.6	-0.2	0.4
Commuting to job workplace: Car/motor vehicle	0.8	1.0	4.2	-0.4	-0.8	0.0	-0.4	-0.5	-2.1	-0.4	1.7	0.6	-1.2	-0.7
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	5.9	-1.1	1.3	-1.8	-1.9	-2.1	0.8	0.6	0.9	-2.3	0.6	-2.4
Medication: Aspirin	0.5	0.6	2.0	0.9	0.8	0.6	0.3	0.8	1.4	-0.1	-0.6	0.4	1.1	0.8
Supplements: Vitamin C	1.7	2.0	4.0	-1.6	1.7	-1.8	-2.0	-1.8	-0.1	-0.6	0.3	-0.6	-2.0	-1.2
Knee pain experienced in last month	0.2	0.3	2.2	-0.3	0.2	-0.4	-0.1	0.2	1.5	-0.4	-0.9	-0.1	-0.3	0.2
Hypertension (Self-reported)	0.7	2.0	9.6	3.1	-1.0	0.9	1.3	1.3	-1.0	1.2	-1.6	-0.4	0.6	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	6.6	0.7	-0.6	0.9	1.1	1.2	2.6	-0.4	0.2	-0.9	0.8	0.3
Illnesses of father: Heart disease	1.0	1.4	4.6	0.4	1.0	-0.2	0.6	0.2	-1.4	1.9	-1.5	-2.1	1.0	1.0
Illnesses of siblings: Diabetes	0.5	0.6	1.5	-0.7	-0.4	-0.3	0.1	0.3	-1.2	-0.4	-1.1	1.1	-0.2	1.1
Smoking status: Previous	0.9	1.4	2.9	0.1	-1.7	1.6	1.3	1.6	0.9	-0.2	0.1	1.6	1.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	16.1	-2.2	0.4	-0.9	-0.9	-0.9	4.0	-0.7	0.6	-0.6	-0.9	-1.4
Whole body fat-free mass	0.7	3.8	11.1	-2.9	-0.2	-1.5	-0.9	-1.2	3.3	-2.8	-0.7	1.3	-2.7	-1.2
Leg fat-free mass (right)	0.5	2.4	9.1	-2.1	-0.0	-0.9	-0.3	-0.6	3.0	-2.1	-1.2	0.9	-2.3	-0.5
Arm fat percentage (left)	0.1	0.4	1.6	0.9	-0.3	0.3	0.6	0.4	0.6	-0.1	-0.9	0.1	-1.3	0.3
Average weekly red wine intake	2.3	3.4	8.2	1.0	-2.2	2.2	2.9	2.8	1.0	0.4	-0.3	1.8	0.6	2.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.7	1.1	-0.2	0.8	0.7	0.8	0.4	1.7	-0.7	-0.5	1.9	0.2
Mood swings	0.9	1.6	6.0	-0.5	-0.5	-1.3	-0.9	-0.7	1.1	-2.0	-0.9	1.0	-2.4	-0.7
Loneliness, isolation	0.3	0.4	1.7	-0.5	0.4	-0.2	-0.2	-0.2	0.9	-0.3	0.4	-1.3	-0.8	-0.8
Long-standing illness, disability or infirmity	0.4	0.6	1.6	1.0	-1.3	0.8	0.8	1.0	0.7	0.2	0.3	0.9	0.4	0.7
Ever had bowel cancer screening	0.5	0.6	3.0	0.1	-1.1	-0.1	0.1	-0.1	-0.9	-0.1	-1.0	0.3	1.7	0.7
Diabetes diagnosed by doctor	0.5	0.9	4.8	-0.1	-0.6	0.4	0.1	0.3	-2.2	0.6	0.1	0.6	1.8	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.2	-1.1	0.2	-1.1	-0.7	-0.7	0.3	-0.7	-1.5	-0.3	-0.9	-0.8
Friendships satisfaction	0.4	0.5	1.3	-0.4	1.1	-0.7	-1.0	-1.0	0.2	-0.3	-0.3	-0.6	0.5	-0.9
Qualifications: nursing, teaching	0.8	1.3	4.8	-0.0	-0.3	1.3	1.0	1.1	-0.1	2.2	-1.6	0.2	0.7	1.5
Commuting to job workplace: Walk	0.2	0.3	0.6	-0.2	0.0	0.6	0.5	0.3	0.2	-0.7	0.2	0.5	-0.7	0.8
Eye problems/disorders: Cataract	1.2	1.4	4.2	0.2	-0.7	1.3	1.7	1.4	0.9	0.9	-0.7	0.9	1.0	2.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	5.4	1.8	-1.0	2.0	2.0	1.9	0.4	0.8	-0.7	0.6	1.5	2.3
Medication for cholesterol	0.3	0.4	1.1	-0.7	0.4	-0.3	-0.6	-0.8	0.8	0.6	1.1	-0.7	-0.3	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	0.4	0.3	0.1	0.1	0.4	-0.7	-0.2	-0.9	-0.9	-0.8	0.6
Back pain experienced in last month	0.4	0.6	1.9	-0.4	0.3	0.4	0.8	0.7	0.4	-0.3	-1.4	0.8	1.0	0.8
Mineral and other dietary supplements	1.7	2.3	4.3	1.8	-0.7	2.1	2.0	1.9	1.7	1.8	-0.2	0.5	0.6	1.9
Breast cancer (self-reported)	1.4	1.7	5.6	1.8	-0.3	1.0	1.1	1.2	0.8	0.3	-0.1	1.0	-2.4	2.1
Asthma (self-reported)	0.3	0.6	1.3	-0.4	-0.9	-1.1	-1.0	-0.8	-0.2	0.3	-0.2	1.1	1.1	-0.3
Osteoporosis (self-reported)	0.5	0.6	2.9	0.2	0.1	-0.9	-0.4	-0.7	1.7	0.9	-1.0	-0.3	-0.7	-0.0
Osteoarthritis (self-reported)	0.3	0.4	1.0	-0.3	0.3	-0.7	-0.7	-0.8	1.0	-0.6	-0.8	-0.0	0.1	-0.7
Medication: Aspirin	0.5	0.7	2.8	0.8	0.5	0.7	0.4	0.8	1.7	-0.5	-0.3	0.6	1.0	0.9
Medication: Gliclazide	0.1	0.1	0.6	-0.0	-0.8	-0.1	0.2	-0.1	0.2	-0.1	0.0	0.2	0.1	-0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	-1.1	0.8	-0.1	-0.5	0.1	1.3	-1.4	-0.2	1.2	-0.1	0.2
Smoking status: Current	0.3	0.5	1.7	1.1	-1.3	0.1	0.6	0.3	-0.9	-0.8	0.6	0.2	0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.8	0.2	-0.4	-0.6	-0.3	-0.4	0.7	0.0	0.2	0.6	0.4
Whole body water mass	0.7	3.9	11.0	-3.0	-0.1	-1.5	-1.0	-1.2	3.3	-2.9	-0.7	1.3	-2.6	-1.2
Leg predicted mass (right)	0.5	2.5	10.2	-2.1	-0.0	-0.9	-0.3	-0.6	3.2	-2.0	-1.2	0.9	-2.2	-0.6
Arm fat mass (left)	0.1	0.6	2.6	-0.1	-0.4	-0.2	0.1	-0.1	1.2	-0.9	-0.9	0.8	-1.6	-0.0
Number of self-reported non-cancer illnesses	1.6	2.7	7.5	1.8	-2.1	1.2	1.8	1.5	-0.7	1.9	-0.9	1.0	2.7	1.4
Average weekly champagne plus white wine intake	0.5	0.7	4.9	-0.3	0.9	-0.2	-0.2	-0.1	0.5	-0.5	-2.2	0.4	-1.0	0.7
Miserableness	0.3	0.5	1.7	-0.3	-1.0	0.1	-0.1	0.3	0.6	-0.5	-0.5	1.2	-1.3	0.5
Guilty feelings	0.3	0.5	2.0	-0.3	0.9	-0.5	-0.3	-0.5	-0.8	0.5	-0.6	-1.4	-0.5	-0.6
Wears glasses or contact lenses	2.9	3.4	8.1	2.8	-1.8	2.3	2.5	2.0	-0.7	1.8	1.5	0.2	1.4	1.6
Ever taken oral contraceptive pill	0.2	0.3	1.8	0.7	-0.1	-0.2	0.2	-0.1	0.5	0.0	-0.1	-0.5	-1.3	0.4
Hearing aid user	0.4	0.5	1.5	-0.3	-0.8	0.6	0.4	0.4	-0.6	0.7	0.6	1.2	0.0	1.0
Mother’s age at death	0.5	0.6	1.5	-0.7	-0.9	0.9	1.0	0.8	-0.1	-0.5	-0.3	0.9	-0.9	1.2
Financial situation satisfaction	0.5	0.6	2.8	-1.0	1.2	-0.2	-0.3	-0.5	0.4	0.7	-0.0	-1.7	0.6	-0.0
Tinnitus: Yes, now most or all of the time	0.8	0.9	5.1	0.3	-1.4	-1.1	-0.6	-0.6	-0.6	-0.4	-0.5	2.3	-0.1	-0.3
Commuting to job workplace: Public transport	1.6	1.9	6.2	0.2	1.5	-0.2	0.2	0.3	2.2	1.6	-2.5	-0.7	1.8	0.9
Eye problems/disorders: Glaucoma	0.5	0.6	2.0	-1.1	-0.4	-0.8	-0.5	-0.5	-0.4	0.5	-1.2	1.4	0.7	-0.1
Medication: Blood pressure	0.7	1.4	4.0	1.6	-0.6	0.3	0.7	1.2	-0.5	0.0	-2.0	1.9	-0.6	1.4
Pain type(s) experienced in last month: Hip pain	2.1	2.7	9.7	1.0	-3.1	0.9	1.2	1.3	2.2	0.1	-0.5	2.5	2.0	0.4
Supplements: Fish oil (including cod liver oil)	2.4	3.1	10.9	-1.6	1.0	-1.6	-1.9	-1.5	-1.5	-3.3	1.1	-0.5	-2.0	-1.9
High cholesterol (Self-reported)	1.1	2.0	3.6	-0.8	1.1	-1.6	-1.6	-1.7	-1.9	1.1	-0.0	-1.7	1.4	-1.5
Medication: Bendroflumethiazide	0.6	0.9	3.0	1.7	-0.3	0.5	0.8	1.1	-0.4	-0.3	-1.0	1.2	0.2	1.6
Medication: Paracetamol	0.6	1.0	3.8	-0.7	-0.1	-0.9	-1.3	-1.2	-0.5	-1.9	0.3	0.2	-0.2	-1.4
Medication: Lisinopril	1.2	1.6	3.7	1.6	-0.3	1.9	1.7	1.7	0.5	-0.0	-1.2	-0.3	0.2	1.9
Medication: Atorvastatin	0.5	0.7	1.7	0.4	0.4	0.8	0.8	0.8	1.0	-1.3	1.0	-1.0	-0.3	0.5
Illnesses of father: High blood pressure	0.3	0.3	1.0	-0.4	0.5	-0.7	-0.8	-1.0	-0.6	0.3	-0.0	-0.6	0.3	-0.7
Alcohol drinker status: Never	0.9	1.1	3.6	1.5	-0.4	-0.1	0.5	0.1	1.8	1.9	-0.6	-0.5	1.5	0.3
Ever smoked	1.0	1.8	4.5	1.4	-1.7	2.1	2.0	2.0	-0.2	-0.3	0.9	0.6	0.8	0.6
Basal metabolic rate	0.7	3.6	11.3	-2.6	-0.2	-1.3	-0.8	-1.0	3.4	-2.7	-0.8	1.4	-2.7	-1.1
Leg fat percentage (left)	0.3	1.0	2.8	1.7	-1.0	0.8	1.0	0.8	-0.7	-0.1	-0.7	1.2	-1.1	1.1
Arm fat-free mass (left)	0.8	3.9	10.4	-2.8	-0.1	-1.7	-1.2	-1.4	2.6	-3.2	-0.3	1.6	-2.7	-1.4
Number of operations (self-reported)	0.5	0.7	1.7	-0.9	-0.4	-1.1	-1.0	-1.3	0.9	0.1	-0.4	1.1	-0.6	-0.9
Average weekly beer plus cider intake	0.1	0.2	0.6	0.7	0.0	0.3	0.0	0.5	-0.6	-0.8	0.1	-0.3	0.2	-0.2
Irritability	0.2	0.4	1.5	0.6	-0.9	0.8	0.2	0.4	0.1	0.0	1.2	0.5	-0.2	0.0
Risk taking	0.3	0.5	2.4	-1.5	-0.4	-0.3	-0.0	-0.2	1.4	-0.7	-0.2	0.2	0.4	-0.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.2	0.5	0.2	1.0	1.2	0.9	0.5	0.8	-0.2	-1.1	0.6	1.5
Fractured/broken bones in last 5 years	1.1	1.4	9.8	0.6	-0.9	0.7	0.5	0.5	1.4	3.1	0.2	-0.2	1.1	0.2
Age started oral contraceptive pill	1.2	1.5	3.7	1.3	-1.9	1.4	1.6	1.3	-0.4	0.4	0.6	1.4	-0.1	1.6
Diastolic blood pressure, automated reading	0.3	1.0	3.1	0.5	-0.3	1.2	1.3	0.9	0.9	-1.8	-0.2	0.1	-1.7	0.6
Ever depressed for a whole week	0.6	0.8	4.4	0.2	0.1	0.2	0.3	0.4	2.1	1.1	-0.8	-0.3	1.4	0.1
Unable to work because of sickness or disability	0.8	1.1	7.8	0.6	-0.6	0.4	0.8	0.5	1.0	0.9	-0.3	0.2	2.8	0.1
Commuting to job workplace: Cycle	0.3	0.3	2.1	-0.7	0.6	0.3	0.6	0.2	0.4	0.1	-1.4	-0.3	-0.3	0.3
Myopia	0.7	1.0	5.2	-0.6	-0.1	-0.1	0.6	0.5	-0.8	1.3	-1.2	-0.1	2.3	0.9
Vascular/heart problems diagnosed by doctor	0.8	2.3	11.0	-3.3	1.5	-1.2	-1.5	-1.6	0.6	-1.0	1.5	-0.3	-0.8	-1.2
Cholesterol lowering medication	0.1	0.2	1.2	0.0	-0.5	0.1	0.1	0.3	-1.1	0.7	-0.3	0.5	-0.1	0.0
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	5.3	1.2	-0.4	1.5	1.2	1.1	2.3	0.4	1.6	-0.4	1.7	0.5
Pain experienced in last month	0.6	0.9	1.8	1.1	-1.1	1.3	1.3	1.3	-0.0	0.3	0.6	0.9	0.6	1.1
Supplements: Calcium	0.3	0.3	1.7	-0.2	0.6	-0.1	0.0	0.4	-0.2	1.3	-0.8	0.4	0.2	0.7
Basal cell carcinoma (self-reported)	0.5	0.6	2.3	-1.5	0.3	-0.5	-0.5	-0.6	1.5	0.8	-0.3	0.3	0.6	-0.5
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.4	0.4	0.7	-0.3	-1.0	-0.8	-0.7	-0.4	1.5	-1.4	-0.1	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.5	0.2	-0.6	-0.6	-0.5	-0.2	0.4	-0.5	-0.6	-0.5	-0.6
Heart disease (siblings)	1.1	1.4	3.5	0.5	0.2	-0.0	0.1	0.3	-1.7	1.8	-1.9	0.5	1.7	1.4
Alcohol drinker status: Previous	0.8	0.9	8.4	0.4	-0.4	0.1	0.2	0.3	-2.9	-0.5	0.1	0.8	0.6	-0.1
Pack years of smoking	0.3	0.4	1.2	0.9	0.2	1.1	1.1	0.8	0.7	-0.2	0.1	-0.0	0.3	0.6
Impedance of whole body	0.4	1.8	4.0	1.4	-0.8	1.8	1.3	1.7	0.5	1.5	2.0	0.3	1.6	0.6
Leg fat mass (left)	0.2	0.7	2.4	0.7	-0.7	0.3	0.7	0.3	0.6	-0.5	-0.9	1.2	-1.6	0.6
Arm predicted mass (left)	0.8	4.2	11.5	-2.9	-0.4	-1.7	-1.1	-1.3	2.6	-3.4	-0.5	2.1	-2.8	-1.2