Hub : Genes

CTBP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1010	0.0380	1.6e-03	0.018	NA	0.019	NA	0.010	3.2e-02	NA	3.0e-02	NA	8.2e-02
2	GTEx	Muscle Skeletal	0.0530	0.0232	2.8e-03	0.023	NA	0.024	NA	0.026	2.3e-03	NA	2.0e-03	NA	1.2e-03
3	GTEx	Nerve Tibial	0.0897	0.0370	2.3e-03	0.020	NA	0.008	NA	0.011	1.3e-02	NA	8.3e-02	NA	5.1e-02
4	GTEx	Testis	0.1970	0.0550	8.7e-06	0.197	NA	0.177	NA	0.191	4.0e-09	NA	2.6e-08	NA	7.0e-09
5	METSIM	Adipose	0.0280	0.0131	3.4e-03	0.005	0.008	0.002	0.005	-0.002	4.6e-02	2.0e-02	1.7e-01	5.5e-02	8.0e-01
6	NTR	Blood	0.0486	0.0126	2.3e-12	0.038	0.043	0.043	0.043	0.036	2.7e-12	6.6e-14	8.4e-14	8.8e-14	8.1e-12
7	ROSMAP	Brain Pre-frontal Cortex	0.0570	0.0212	1.7e-04	0.041	0.030	0.030	0.031	0.029	4.8e-06	8.6e-05	8.5e-05	6.7e-05	1.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.4	2.2	6.3	-0.5	2.5	-0.9	-1.5	-1.5	-1.7	-0.5
Bipolar Disorder or Schizophrenia	1.5	3.7	10.0	-1.5	3.2	-0.7	-1.3	-2.8	-1.7	-0.9
Depressed Affect (Nagel 2018)	2.4	5.1	11.1	3.3	-2.5	2.4	2.6	2.2	0.4	0.7
Depression (Nagel 2018)	0.4	0.7	1.3	1.1	-1.1	0.8	1.0	0.2	0.7	0.2
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.8	-1.3	0.6	-1.8	-1.1	-1.2	-0.4	-1.9
Neuroticism (Nagel 2018)	0.4	0.9	1.8	1.3	-0.8	0.7	0.7	1.1	-0.7	-1.0
Schizophrenia (2018)	0.9	1.9	5.3	-1.5	2.0	-0.2	-0.5	-2.3	-0.7	-0.7
Schizophrenia vs Biploar Disorder	0.7	1.0	1.6	0.4	-1.3	1.0	1.0	0.6	1.1	1.2
Worry (Nagel 2018)	1.1	2.3	5.1	-0.7	2.3	-0.9	-1.3	-1.0	-2.0	-1.7
Alzheimer’s Disease (in mother)	3.6	4.2	6.5	-2.1	2.0	-1.8	-2.5	-2.1	-1.8	-1.9
Alzheimer’s Disease (in father)	0.6	0.6	1.3	1.0	-1.0	0.6	0.7	0.4	0.5	1.1
Alzheimer’s Disease (including proxy)	1.6	2.3	3.9	-2.0	0.9	-1.5	-1.7	-1.2	-1.2	-1.8
Crohns Disease (2017)	0.5	1.1	2.1	-1.3	1.5	-0.9	-1.1	-1.1	-0.8	-0.6
Irritable Bowel Disease (IBD)	1.0	2.4	3.7	-1.0	1.9	-1.3	-1.4	-1.7	-1.6	-1.6
Ulcerative Colitis (UC)	1.3	2.4	5.0	-0.7	1.7	-1.3	-1.2	-1.5	-1.8	-2.2
Major Depression (MDD)	0.3	0.3	2.2	0.0	0.0	0.0	0.0	0.0	0.0	1.5
Reaction Time	0.3	0.6	2.0	-1.4	0.5	-0.7	-0.6	-0.5	-0.1	-1.0
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.4	-1.5	0.3	-1.8	-1.4	-1.1	-0.5	-1.6
Breast Cancer	2.8	6.8	10.6	3.2	-1.1	3.0	2.5	2.7	2.2	3.0
Ovarian Cancer	0.1	0.1	0.4	0.3	0.2	-0.5	-0.4	-0.6	0.1	0.2
Prostate Cancer	3.9	5.4	8.1	1.8	-2.9	2.7	2.8	2.1	2.0	1.7
Age at First Birth	0.2	0.3	0.9	1.0	-0.3	0.5	0.1	0.8	-0.1	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	2.5	-0.6	1.1	-0.2	-0.6	-0.1	0.3	1.6
Coronary Artery Disease (CAD)	0.6	0.8	1.7	0.3	1.2	-0.6	-0.5	-1.3	-1.2	-0.4
Crohns Disease (2012)	1.7	2.7	4.8	-2.1	1.8	-1.5	-1.4	-2.2	-1.3	-0.8
Mean Putamen Volume	2.9	3.4	8.5	0.4	-1.8	1.8	1.5	1.5	2.9	2.0
Fasting Glucose	1.3	1.6	3.2	-1.8	1.2	-1.0	-0.9	-1.7	-1.0	-0.9
HbA1C	1.1	1.3	2.4	-1.0	1.2	-0.8	-1.3	-1.5	-1.2	0.4
HDL Cholesterol	0.2	0.4	1.4	-1.2	0.1	-0.6	-0.4	-0.6	-0.4	-0.7
LDL Cholesterol	2.6	4.2	7.9	1.3	-1.9	1.9	1.6	2.7	2.8	1.8
Lupus	0.4	0.6	1.9	-1.1	1.4	0.0	0.0	-0.8	-0.6	-0.3
Neuroticism (2016)	1.3	1.9	3.8	1.8	-1.4	1.2	1.6	2.0	0.5	-0.0
Primary Biliary Cirrhosis	8.8	12.5	19.8	-3.7	4.4	-2.9	-3.3	-3.5	-3.3	-3.5
Rheumatoid Arthritis	2.5	3.5	5.4	-2.3	2.3	-1.9	-1.7	-1.6	-0.9	-1.9
Schizophrenia (2014)	0.7	1.4	3.6	-1.3	1.9	-0.6	-0.7	-1.7	-0.8	-0.7
Triglycerides	1.1	1.8	3.0	1.0	-1.1	1.3	1.5	0.5	1.7	1.7
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	0.4	-0.0	0.9	0.9	-0.5	0.2	-0.3
Ulcerative Colitis	1.7	2.4	6.1	0.2	2.5	-0.9	-0.9	-2.3	-1.8	-0.8
Blood Eosinophil Count	0.1	0.8	1.7	0.2	1.1	-0.6	0.2	-1.3	-1.0	-1.2
Blood Platelet Count	0.1	1.1	3.6	-0.8	0.7	-0.7	-0.7	-1.1	-1.9	-0.7
Blood Red Count	0.5	4.9	12.1	3.5	-2.4	2.1	2.1	2.7	0.4	0.5
Blood White Count	0.2	1.7	9.5	-0.6	0.4	-0.3	0.3	-3.1	-1.1	-0.7
Heel T-Score	3.6	28.6	130.0	-2.5	5.8	2.3	-0.0	-0.7	5.0	11.4
BMI	0.3	1.7	5.3	1.9	0.2	-0.1	-0.2	-0.6	-1.6	2.3
Height	0.9	18.1	58.7	0.7	-2.0	5.3	4.5	1.4	3.6	7.7
Waist Hip Ratio (WHR)	6.5	29.4	46.3	6.8	-4.7	4.5	4.7	3.8	6.3	6.4
Systolic Blood Pressure	0.4	1.8	6.8	1.7	0.5	1.2	0.4	-1.0	-0.6	2.6
Smoking Status	2.2	5.2	8.0	2.8	-2.7	1.8	1.7	1.9	2.5	2.4
Allergy or Eczema	0.1	0.4	0.9	0.3	0.0	0.8	0.8	-0.4	-0.5	-1.0
Cardiovascular Disease	0.8	2.7	8.3	2.8	-0.6	1.2	0.8	-0.0	-0.1	2.9
Hypothyroidism (self reported)	0.9	2.1	5.8	2.4	-1.2	1.2	1.1	0.7	0.2	2.1
Respiratory disease	0.7	1.6	2.3	-1.2	1.0	-1.5	-1.2	-0.8	-1.5	-1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.8	1.3	-0.2	-0.1	0.4	-0.9	-0.7	-0.2
Lung FEV1/FVC ratio	1.1	5.6	25.0	5.0	-0.6	1.6	1.3	1.4	0.6	2.7
Lung FVC	0.4	2.0	6.0	-2.0	0.5	1.3	0.5	1.4	2.5	0.1
Neuroticism	0.3	0.7	2.0	1.4	-0.5	0.7	0.6	1.1	-0.8	-0.4
Chronotype (morning person)	6.9	16.1	22.4	-3.3	3.9	-4.0	-3.9	-4.3	-3.8	-4.7
Hair Pigment	0.3	7.7	10.1	-3.2	3.2	-2.2	-2.5	-2.8	-3.0	-2.4
Tanning	0.1	1.5	4.9	-1.2	-1.3	-1.2	-0.8	0.5	-0.1	-2.2
Hand grip strength (left)	2.0	5.2	8.4	1.4	-1.7	2.5	2.0	2.2	2.9	2.9
Number of treatments/medications taken	0.2	0.4	1.2	0.1	0.4	0.3	0.1	-1.1	-0.7	1.1
Average weekly spirits intake	0.4	0.5	1.7	-0.4	1.3	-0.7	-0.9	-0.7	-0.1	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.3	0.5	-0.6	0.5	0.5	0.2	-0.5	0.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.4	0.0	0.6	0.6	-0.3	0.3	0.1
Hearing difficulty/problems: Yes	0.6	0.9	3.3	-0.9	0.4	-0.6	-0.2	-0.7	-0.9	-1.8
Relative age of first facial hair	0.2	0.3	0.8	0.1	-0.4	-0.7	-0.9	0.7	0.4	-0.4
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	3.2	-1.8	-0.5	0.9	0.8	-0.5	0.8	1.0
Ever used hormone-replacement therapy (HRT)	2.8	3.5	4.9	1.2	-2.0	2.1	1.8	1.6	2.2	2.0
Ever had hysterectomy (womb removed)	0.5	0.6	2.1	-0.8	-1.1	-0.0	0.3	-0.4	0.2	-1.5
Systolic blood pressure, automated reading	1.1	3.3	14.8	1.8	-0.6	1.8	1.1	0.7	0.2	3.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.7	0.7	-1.6	0.5	0.6	0.9	0.3	-0.3
Angina	0.7	0.9	2.1	0.9	-0.7	1.2	0.7	0.3	1.1	1.5
Medication for hormone replacement therapy	0.4	0.5	1.5	1.2	-0.4	0.8	0.7	-0.1	0.5	0.5
Vitamin and mineral supplements	0.0	0.1	0.2	-0.1	-0.0	-0.1	-0.3	0.1	0.3	0.5
Supplements: Zinc	0.4	0.5	1.4	-0.9	-0.4	-0.4	-0.4	0.8	1.2	0.0
Medication: Co-codamol	0.4	0.5	2.1	-1.5	-0.3	-0.5	-0.4	0.0	0.7	0.2
Medication: Metformin	0.6	0.9	2.8	0.3	-0.0	-0.9	-0.3	-0.8	-1.7	-1.4
Diabetes (father)	1.9	2.4	6.7	-0.2	1.0	-1.4	-1.2	-1.2	-2.0	-2.6
Diabetes (mother)	0.5	0.6	1.6	1.0	-0.6	0.6	0.9	1.3	0.5	-0.1
Severe depression (siblings)	0.3	0.4	2.3	-1.5	0.3	-0.3	-0.2	-0.2	-0.2	-0.2
Pack years adult smoking proportion	0.3	0.5	1.3	0.8	-1.2	0.4	0.7	0.9	0.2	0.4
Impedance of leg (right)	0.4	2.1	5.4	1.7	-1.4	0.1	0.8	1.7	2.3	-0.8
Leg fat-free mass (left)	0.4	1.9	11.0	-0.2	0.7	0.9	0.2	-0.5	-0.9	3.3
Trunk fat percentage	0.6	2.5	7.9	2.8	-1.6	0.5	0.9	0.4	0.2	2.4
Hand grip strength (right)	2.5	6.7	10.6	2.0	-1.4	3.2	2.6	2.6	2.6	3.2
Townsend deprivation index at recruitment	0.5	0.7	1.2	1.1	-1.0	0.8	1.1	-0.0	0.4	0.7
Current tobacco smoking	1.6	2.6	4.9	2.2	-1.7	1.0	1.4	1.8	1.7	1.0
Average weekly fortified wine intake	0.3	0.4	0.9	0.5	-0.8	0.1	0.2	0.9	0.5	0.8
Maternal smoking around birth	2.7	3.9	8.6	1.7	-2.9	1.9	2.6	1.5	1.4	1.2
Fed-up feelings	2.0	3.7	7.7	2.8	-2.1	2.0	2.3	1.7	0.2	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	4.7	1.3	-2.2	1.7	1.8	1.8	1.7	1.0
Relative age voice broke	0.9	1.4	3.3	0.4	-1.8	0.1	0.4	1.7	1.8	0.3
Taking other prescription medications	0.2	0.4	1.5	-0.1	0.4	0.0	-0.2	-1.2	-0.8	0.6
Age when periods started (menarche)	0.2	0.5	1.2	-1.1	-0.8	0.2	0.3	0.8	1.1	0.3
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	3.5	0.2	-1.9	1.1	1.2	0.6	1.8	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	13.5	-1.1	2.7	0.2	-0.7	-0.7	0.8	3.7
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.8	2.0	-0.6	1.1	1.1	0.5	0.7	1.4
Qualifications: CSEs or equivalent	0.6	0.8	2.2	1.5	-0.0	0.6	0.3	1.2	-0.2	1.3
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.2	-0.4	0.6	0.5	0.3	0.2	0.3
High blood pressure	0.4	1.1	3.0	1.1	0.6	0.2	-0.3	-1.3	-1.7	1.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.3	0.2	0.5	0.6	-0.6	-0.8	-0.9
Multivitamins +/- minerals	1.0	1.3	3.1	0.9	-1.1	1.5	1.8	0.8	0.6	0.9
Stomach or abdominal pain in last month	0.5	0.6	1.8	-0.8	0.4	-0.7	-0.7	-0.3	-0.6	-1.4
Supplements: Glucosamine	0.4	0.5	1.2	0.4	0.4	1.0	0.6	0.6	-0.2	1.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.9	0.3	0.0	-0.4	-0.1	-1.4	0.0	-0.4
Medication: Atenolol	0.7	0.8	2.3	1.2	-0.5	1.5	1.0	-0.1	-0.3	0.9
Medication: Levothyroxine sodium	0.4	0.6	2.2	1.0	0.8	0.4	-0.2	-0.2	-1.5	0.8
Sitting height	0.3	1.8	8.8	-0.6	0.8	1.5	0.5	-0.3	0.7	3.0
Chronic bronchitis/emphysema (father)	0.2	0.2	1.2	0.4	1.1	-0.2	-0.1	0.0	-0.0	0.2
High blood pressure (mother)	0.3	0.4	1.4	0.3	-0.4	1.0	0.6	-0.2	0.1	1.2
Body mass index (BMI)	0.4	1.8	5.0	1.7	0.6	0.1	-0.2	-0.6	-1.9	2.2
Impedance of leg (left)	0.4	2.2	5.4	2.2	-1.1	0.6	1.0	1.6	2.3	-0.4
Leg predicted mass (left)	0.4	2.1	11.7	-0.0	0.8	1.0	0.3	-0.5	-0.9	3.4
Trunk fat mass	0.6	2.7	10.4	2.4	-1.2	0.9	1.0	0.3	0.0	3.2
Waist circumference	1.9	7.0	22.8	4.0	-1.4	2.1	2.0	0.6	0.1	4.8
Number of incorrect matches in round	0.4	0.6	2.2	-0.8	1.5	-0.0	-0.3	0.2	-0.6	-1.1
Past tobacco smoking	1.0	1.9	4.3	-1.4	1.3	-1.5	-1.1	-0.8	-1.1	-2.1
Alcohol usually taken with meals	0.5	0.8	1.3	0.5	-0.7	1.1	0.7	0.6	1.0	1.1
Nervous feelings	2.2	4.1	9.8	-1.6	1.8	-1.8	-1.7	-0.8	-2.5	-3.1
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.5	1.9	-1.6	1.2	1.4	1.0	0.8	1.3
Hearing difficulty/problems with background noise	0.7	1.2	4.9	0.1	-0.8	-0.6	-0.3	0.9	-1.2	-2.2
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	1.0	0.1	0.7	0.2	0.3	-0.3	0.9
Had menopause	0.7	0.9	2.1	0.6	-0.7	0.7	0.4	1.0	1.2	1.4
Had other major operations	0.3	0.4	1.3	0.1	-1.1	0.7	0.8	0.3	0.6	0.1
Forced vital capacity (FVC)	0.6	2.3	4.4	-2.1	1.5	1.5	0.4	0.1	2.0	1.8
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	21.1	-0.9	1.9	1.5	0.5	0.4	1.8	4.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	0.5	-0.1	0.7	0.6	0.8	-0.0	0.4
Qualifications: None of the above	0.6	1.3	2.6	-0.9	0.5	-1.3	-1.1	-0.8	-1.6	-1.3
Financial difficulties in last 2 years	0.6	0.8	1.5	-1.1	-1.2	0.5	1.2	0.3	0.8	-0.4
Mouth/teeth dental problems	2.1	3.3	6.6	-1.8	2.6	-1.4	-2.0	-1.0	-1.0	-2.2
Heart attack	4.8	6.1	12.6	3.5	-3.5	2.0	2.4	1.8	1.6	1.5
Allergy	0.1	0.3	0.8	-0.2	-0.7	-0.1	-0.2	0.9	0.8	0.5
Pain all over the body in last month	2.1	2.3	7.9	-2.8	-1.0	-0.9	-0.2	0.2	0.4	-2.5
Diabetes (self-reported)	0.2	0.3	1.1	1.1	-0.7	-0.2	0.4	-0.1	-0.3	-0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	-0.6	0.6	-0.4	-0.7	-0.4	-0.8	-0.8
Medication: Ramipril	1.8	2.2	5.6	2.4	-1.8	0.9	1.1	1.9	0.5	1.0
Medication: Simvastatin	0.6	0.9	3.0	1.5	-1.7	0.4	0.8	-0.2	0.4	0.3
Fluid intelligence score	0.6	1.3	2.9	0.0	1.4	-1.1	-1.1	-1.7	-1.2	-0.6
Illnesses of siblings	1.1	1.5	3.1	0.6	-0.6	1.2	0.8	1.6	1.8	1.5
Neuroticism score	0.4	0.8	1.9	1.4	-0.6	0.7	0.7	0.8	-1.1	-0.6
Weight	0.7	3.4	17.9	1.7	0.1	1.4	0.9	0.0	-0.7	4.2
Impedance of arm (right)	0.5	2.3	6.2	0.5	-2.1	-1.5	-0.2	0.1	1.7	-2.5
Arm fat percentage (right)	0.4	1.4	5.3	2.3	-0.9	-0.4	-0.0	-0.2	-0.8	1.7
Trunk fat-free mass	0.7	4.1	21.6	-0.4	1.3	2.0	0.9	-0.1	-0.4	4.7
Hip circumference	0.6	2.4	7.9	0.8	1.0	0.1	-0.3	-1.2	-2.8	2.4
Time employed in main current job	0.3	0.3	1.0	-1.0	-0.3	-0.3	-0.3	0.2	-0.3	-0.8
Alcohol intake versus 10 years previously	0.3	0.4	1.3	0.2	0.3	-0.4	-0.5	-0.9	-1.1	-0.2
Father’s age at death	0.7	0.9	4.5	-0.2	0.4	-1.0	-0.7	0.3	-0.3	-2.1
Worrier / anxious feelings	1.0	2.0	3.7	0.2	1.7	-1.0	-1.4	-0.9	-1.8	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	2.1	-0.4	-0.0	-0.5	-0.2	-0.6	-1.4	-1.0
Falls in the last year	0.5	0.7	3.7	0.1	-0.5	0.8	0.6	0.1	0.3	1.9
Hair/balding pattern: Pattern 3	1.0	1.5	3.1	1.7	-0.7	1.2	1.2	0.5	1.0	1.8
Number of live births	0.6	0.8	1.6	-0.4	1.3	-1.0	-1.0	-1.0	-1.0	-0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.4	-0.7	1.1	1.8	0.8	0.7	1.9	2.1
Pulse rate	2.2	3.8	8.7	-1.4	1.0	-2.2	-2.0	-1.4	-2.0	-2.9
Happiness	4.5	5.5	7.9	2.1	-2.6	2.2	2.6	2.8	2.2	1.6
Noisy workplace	1.0	1.3	2.8	0.7	-0.2	1.7	1.4	0.7	0.7	1.7
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.9	-0.1	0.3	-0.4	0.1	-1.0	0.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.1	-0.1	0.0	0.3	0.2	1.1	-0.3	-0.7
Mouth/teeth dental problems: Dentures	5.3	9.0	16.0	2.6	-3.8	2.4	3.0	2.3	2.4	4.0
Asthma	0.3	0.6	0.9	-0.6	0.5	-1.0	-0.7	-0.8	-0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.1	0.4	0.2	-0.2	0.1	-0.5	0.4
Medication: Cholesterol lowering	1.0	1.6	5.8	2.4	-0.4	1.1	1.0	-0.9	-0.6	1.2
Depression (self-reported)	0.3	0.4	0.8	-0.1	0.8	-0.7	-0.8	-0.4	-0.9	-0.3
Medication: Lansoprazole	1.0	1.1	2.1	0.0	-1.4	0.8	0.8	1.1	1.3	1.1
Prospective memory result	0.7	0.9	1.7	-0.8	0.9	-1.1	-1.1	-1.3	-0.6	-0.2
Lung cancer (father)	0.6	0.7	1.8	0.3	1.0	-0.2	-0.6	-1.3	-0.8	0.9
Illnesses of mother	0.2	0.3	0.6	-0.3	-0.6	-0.4	-0.0	0.8	0.6	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	7.8	0.7	-0.5	2.8	1.9	2.0	2.3	2.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.4	-0.7	0.2	-0.9	-1.2	-0.1	-0.2	-0.7
Impedance of arm (left)	0.5	2.3	6.2	0.8	-2.5	-0.7	0.4	0.8	2.3	-1.7
Arm fat mass (right)	0.4	1.8	8.2	1.8	-0.4	0.3	0.2	-0.2	-0.8	2.9
Trunk predicted mass	0.7	3.9	20.6	-0.5	1.3	1.9	0.8	-0.1	-0.4	4.5
Standing height	0.7	7.2	22.3	0.1	-1.1	3.2	2.5	1.4	2.9	4.7
Length of working week for main job	0.1	0.1	0.3	-0.1	0.4	-0.5	-0.4	-0.0	0.0	-0.1
Exposure to tobacco smoke at home	0.4	0.5	1.8	-0.5	-0.6	-0.7	-0.1	-0.5	-0.2	-1.3
Breastfed as a baby	1.8	2.3	4.1	0.5	-1.2	1.7	1.8	1.5	2.0	1.2
Tense / ‘highly strung’	1.7	2.9	5.1	-0.7	1.5	-2.1	-1.7	-1.5	-1.7	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.4	0.4	-0.2	-1.2	-0.7	0.2	-1.0	-1.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.7	0.2	0.8	0.5	0.2	-0.1	-0.5	-0.0
Birth weight of first child	0.9	1.6	2.9	1.7	-0.9	0.7	1.0	1.2	1.6	1.4
Peak expiratory flow (PEF)	0.5	1.1	2.8	0.5	-0.5	1.3	1.0	1.2	1.7	0.7
Pulse wave reflection index	1.0	1.2	3.7	-0.4	-0.5	-1.5	-1.3	0.3	-0.1	-1.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.7	0.8	-0.3	-0.2	-0.4	-0.4	-0.0
Loud music exposure frequency	0.3	0.3	1.3	1.1	0.0	-0.1	-0.3	-0.4	-0.3	0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.6	0.6	0.3	-0.8	-0.6	-0.8	-0.5	-0.7
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.4	-1.2	0.8	-1.3	-0.9	-1.8	-0.8	-1.1
Blood clot in the leg (DVT)	0.2	0.3	0.9	-0.5	0.9	-0.3	-0.2	-0.6	0.3	0.3
Medication: Paracetamol	0.6	1.1	2.3	-1.5	0.4	-1.4	-1.4	-0.4	-0.9	-0.1
Headache pain in last month	0.3	0.6	1.1	0.4	-0.1	0.9	1.0	1.0	0.9	0.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.2	-1.8	-0.2	-1.0	-0.7	0.9	0.6	-1.7
Glaucoma (self-reported)	2.7	3.2	6.2	-2.5	2.0	-1.4	-1.3	-2.2	-1.2	-1.4
Gout (self-reported)	2.6	3.5	12.1	-0.8	1.8	-1.2	-1.6	-3.5	-2.1	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.7	1.3	0.0	0.3	0.0	0.2	-0.6	1.2
Medication: Amlodipine	3.9	5.5	8.0	2.0	-2.3	2.3	2.5	2.8	1.4	2.8
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.6	-0.4	1.0	-1.2	-1.1	-0.6	-1.6	-0.8
Birth weight	0.4	0.8	2.9	-1.7	-0.3	-1.2	-0.8	-0.4	0.4	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	0.7	0.2	0.6	0.5	0.0	-0.5	0.7
High blood pressure (siblings)	3.0	4.3	9.3	-0.3	1.8	-1.8	-1.6	-2.4	-3.1	-2.5
Forced vital capacity (FVC), Best measure	0.9	3.3	7.2	-0.2	-0.0	2.7	1.6	1.5	2.3	2.4
Body fat percentage	0.7	2.9	10.3	3.2	-1.5	0.7	1.0	0.6	-0.0	2.5
Leg fat percentage (right)	0.7	2.4	9.0	3.0	-1.0	0.5	0.7	0.8	-0.3	2.3
Arm fat-free mass (right)	0.8	4.1	20.7	0.3	1.0	2.2	1.1	0.3	-0.5	4.6
Exposure to tobacco smoke outside home	1.1	1.5	4.0	2.0	-1.0	1.2	1.6	-1.0	-0.0	0.6
Comparative body size at age 10	0.2	0.6	2.0	0.6	0.7	0.3	0.5	-1.4	-0.5	1.0
Number of full brothers	0.2	0.2	1.4	0.3	0.2	-0.2	-0.1	-1.2	-0.3	-0.1
Worry too long after embarrassment	0.2	0.4	1.0	0.3	-0.2	0.9	0.6	1.0	0.3	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.8	-0.7	-0.9	-0.6	0.1	0.0	-0.1	-1.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.7	0.1	-0.4	0.2	0.1	0.8	-0.3	0.0
Number of children fathered	0.2	0.3	0.6	-0.4	-0.8	0.4	0.8	-0.2	0.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.4	-1.8	1.0	-0.4	-0.9	-0.1	-0.3	-0.9
Age at first live birth	0.7	1.3	3.5	1.9	-1.3	1.1	1.1	1.2	0.2	-0.1
Pulse wave peak to peak time	0.5	0.6	1.7	0.5	-0.3	1.1	1.3	0.3	0.4	0.9
Health satisfaction	0.3	0.4	1.4	-0.3	-0.7	0.4	0.6	0.4	0.4	1.2
Shortness of breath walking on level ground	1.2	1.4	2.6	-1.0	1.6	-1.1	-0.9	-1.6	-1.2	-0.5
Qualifications: College or University degree	0.1	0.4	1.1	-0.1	-0.9	0.2	0.6	0.2	1.0	-0.6
Eye problems/disorders: None of the above	1.0	1.2	6.9	2.6	-0.7	0.3	0.3	0.8	0.0	0.6
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.9	1.7	-1.2	1.1	1.1	0.9	0.1	1.5
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.7	-0.0	0.6	0.6	0.2	-0.1	0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	1.1	-0.2	1.0	-0.1	-0.2	-0.1	-0.3	-0.7
Neck or shoulder pain in last month	1.4	2.1	5.7	-2.4	1.9	-0.4	-0.9	-1.4	-1.4	-0.1
Medication: Blood pressure	0.6	1.0	2.8	1.1	1.0	0.7	0.2	-0.8	-1.1	1.7
Angina (self-reported)	0.9	1.1	1.7	1.3	-0.8	1.3	0.8	0.6	1.2	1.3
Migraine (self-reported)	0.1	0.1	0.8	0.1	0.9	-0.0	0.1	0.4	-0.1	0.1
Medication: Ibuprofen	0.3	0.4	0.7	-0.8	0.8	-0.6	-0.8	-0.2	-0.5	-0.5
Medication: Allopurinol	2.0	2.7	10.2	-1.0	1.3	-1.0	-1.3	-3.2	-1.7	-0.6
Medication: Omeprazole	2.4	2.9	4.6	-0.7	1.5	-2.1	-2.0	-1.9	-2.0	-1.0
Medication: Seretide 50 evohaler	0.5	0.6	1.3	-1.1	0.9	-0.4	-0.5	-0.3	-0.8	-0.8
Mean time to correctly identify matches	1.1	2.0	4.1	-2.0	0.9	-1.4	-1.1	-1.5	-1.0	-1.7
Heart disease (mother)	6.8	8.3	13.7	3.7	-2.0	3.7	3.3	1.5	1.4	3.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.8	-0.5	-0.2	-0.1	0.0	0.1	0.9	-0.0
Whole body fat mass	0.7	2.8	10.7	2.5	-0.9	0.9	0.9	0.3	-0.3	3.3
Leg fat mass (right)	0.6	2.4	10.0	2.3	-0.3	0.7	0.6	0.0	-0.7	3.2
Arm predicted mass (right)	0.9	4.5	22.5	0.2	0.8	2.5	1.3	0.5	-0.2	4.7
Pulse rate, automated reading	6.8	22.0	29.4	-2.9	4.4	-5.4	-5.2	-4.7	-5.0	-4.8
Alcohol intake frequency.	0.5	1.2	4.4	2.1	-0.2	0.4	0.7	-1.0	-1.5	-0.3
Comparative height size at age 10	0.6	3.4	15.5	-1.7	0.9	1.6	0.5	-0.4	1.3	3.9
Number of full sisters	5.1	6.2	10.4	-1.5	2.5	-3.0	-3.2	-2.4	-2.5	-2.0
Suffer from ‘nerves’	0.1	0.2	0.6	-0.7	0.5	0.0	-0.2	0.2	-0.8	-0.2
Overall health rating	0.2	0.4	1.3	-0.8	0.2	0.1	0.5	-1.2	-0.8	-0.0
Chest pain or discomfort	0.1	0.2	0.7	0.0	-0.4	-0.4	-0.3	0.1	-0.5	-0.9
Had major operations	0.1	0.2	0.5	-0.3	0.5	0.5	-0.0	-0.2	-0.1	0.7
Age at last live birth	0.7	1.0	2.0	1.4	-1.2	1.2	0.9	0.8	0.6	0.5
Family relationship satisfaction	1.3	1.6	3.1	-0.4	-1.4	1.0	1.6	1.8	1.4	0.4
Leg pain on walking	0.5	0.6	2.8	-1.7	0.3	0.1	0.2	-1.0	-0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	1.9	0.5	-1.2	1.0	0.7	0.7	1.4	1.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.6	-1.3	0.0	-1.0	-1.1	0.1	-0.4	-0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	0.0	0.1	-1.1	-1.3	-0.8	-0.7	0.1
Medication: Aspirin	3.0	4.0	5.6	2.2	-2.4	2.1	2.4	0.6	1.9	1.9
Supplements: Vitamin C	0.1	0.1	0.6	0.8	0.3	-0.1	-0.0	-0.3	0.0	-0.1
Knee pain experienced in last month	0.5	0.8	2.7	-1.6	0.6	0.5	0.3	-0.5	-0.9	0.9
Hypertension (Self-reported)	0.4	1.2	3.4	1.5	0.2	0.6	0.2	-1.0	-1.1	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.7	-1.5	0.6	-1.7	-1.4	-1.0	-0.3	-0.9
Illnesses of father: Heart disease	1.0	1.4	3.3	1.0	-1.4	1.3	0.7	1.8	1.0	0.9
Illnesses of siblings: Diabetes	3.0	3.7	7.7	-2.3	1.0	-2.0	-1.8	-1.7	-1.2	-2.8
Smoking status: Previous	1.5	2.3	3.8	1.5	-2.0	1.5	1.2	1.4	1.1	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.1	-0.1	0.1	1.2	0.9	0.8	0.7	1.7
Whole body fat-free mass	0.6	3.4	18.8	-0.2	1.0	1.8	0.8	-0.2	-0.6	4.3
Leg fat-free mass (right)	0.4	2.2	12.0	-0.1	1.0	1.1	0.2	-0.7	-1.0	3.5
Arm fat percentage (left)	0.4	1.8	6.3	2.5	-1.1	0.0	0.3	0.1	-0.6	2.1
Average weekly red wine intake	0.2	0.3	0.6	-0.1	0.5	-0.7	-0.8	-0.7	-0.0	-0.3
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.0	-0.7	1.1	-1.8	-2.0	-1.1	-1.3	0.1
Mood swings	1.3	2.3	6.3	1.7	-2.5	1.2	1.7	1.6	0.5	0.1
Loneliness, isolation	2.0	2.8	5.0	2.0	-2.1	1.6	2.2	1.9	0.4	0.2
Long-standing illness, disability or infirmity	0.5	0.8	2.4	-1.5	0.2	0.2	0.6	-1.4	-0.2	0.9
Ever had bowel cancer screening	1.6	1.8	4.9	-2.2	0.0	-1.2	-0.7	-1.2	-0.5	-2.1
Diabetes diagnosed by doctor	0.3	0.5	1.9	1.4	-0.9	-0.1	0.5	-0.1	-0.3	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	2.8	3.0	7.1	0.6	-2.7	1.3	1.6	2.2	2.0	0.4
Friendships satisfaction	3.1	3.8	5.2	1.5	-2.1	1.9	2.1	2.3	1.7	2.1
Qualifications: nursing, teaching	0.3	0.4	1.7	-0.4	-0.4	0.0	0.9	-0.0	0.2	-1.3
Commuting to job workplace: Walk	0.2	0.2	0.7	0.2	-0.9	-0.2	-0.2	0.3	0.6	-0.3
Eye problems/disorders: Cataract	0.7	0.8	1.6	-1.1	-0.5	0.9	0.9	0.2	1.3	1.0
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	5.2	-1.2	2.0	-1.9	-2.0	-2.3	-2.3	-1.6
Medication for cholesterol	1.3	2.0	5.9	-2.4	1.5	-1.1	-1.2	-0.9	-0.9	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	-0.6	-0.5	-0.1	0.0	-0.3	0.2	0.4
Back pain experienced in last month	1.0	1.4	3.9	-0.8	2.0	-0.0	-0.8	-0.6	-1.6	1.3
Mineral and other dietary supplements	0.9	1.3	3.1	-0.0	0.9	-1.8	-1.6	-0.6	-0.8	-1.2
Breast cancer (self-reported)	1.4	1.7	3.2	-1.4	0.4	-1.4	-0.9	-1.3	-1.8	-1.6
Asthma (self-reported)	0.4	0.9	1.4	-0.7	0.8	-1.1	-0.9	-1.0	-1.2	-0.6
Osteoporosis (self-reported)	1.2	1.5	4.2	-1.1	-2.0	0.3	1.1	1.0	1.2	-1.2
Osteoarthritis (self-reported)	0.9	1.2	5.8	-2.4	-0.9	0.1	0.4	-0.5	0.6	0.9
Medication: Aspirin	3.6	4.7	6.7	2.6	-2.4	2.2	2.5	0.9	2.0	2.1
Medication: Gliclazide	1.0	1.1	4.2	-0.8	-1.3	-0.8	0.0	-0.6	0.1	-2.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.5	-1.0	0.2	0.0	0.2	-1.2	-0.0	0.4
Smoking status: Current	0.9	1.5	3.4	1.9	-1.3	0.5	0.9	1.1	1.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	5.6	1.2	-1.0	2.4	1.7	2.2	2.0	1.5
Whole body water mass	0.6	3.6	19.5	-0.1	1.1	1.8	0.8	-0.2	-0.6	4.4
Leg predicted mass (right)	0.4	2.1	11.4	-0.2	1.0	1.0	0.2	-0.7	-1.0	3.4
Arm fat mass (left)	0.4	1.7	8.4	1.7	-0.2	0.2	0.0	-0.3	-0.9	2.9
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.1	-0.0	0.4	0.5	-0.7	-0.4	0.6
Average weekly champagne plus white wine intake	1.4	1.9	5.8	0.8	-0.6	1.7	1.6	0.1	1.3	2.4
Miserableness	1.6	2.8	9.1	3.0	-1.4	1.6	1.7	1.7	0.3	0.8
Guilty feelings	1.6	2.4	5.7	1.5	-1.7	1.5	1.7	2.4	0.7	0.4
Wears glasses or contact lenses	0.2	0.3	0.8	-0.9	0.2	0.6	0.6	0.1	-0.7	-0.1
Ever taken oral contraceptive pill	0.8	0.9	2.5	0.2	-0.4	0.9	0.9	1.0	1.6	0.9
Hearing aid user	0.7	0.8	2.7	-0.9	0.2	-1.0	-0.7	-1.7	-0.7	-0.6
Mother’s age at death	3.0	3.8	6.3	0.7	-1.5	2.4	2.5	1.8	2.1	2.1
Financial situation satisfaction	0.2	0.2	0.7	-0.8	0.2	-0.6	-0.3	-0.5	-0.4	-0.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.2	-0.8	0.2	-0.6	-0.7	-1.5	-0.9	-0.9
Commuting to job workplace: Public transport	0.8	1.0	2.5	1.1	-0.6	1.4	1.6	-0.0	0.1	0.9
Eye problems/disorders: Glaucoma	2.7	3.2	9.1	-3.0	1.9	-1.2	-1.1	-2.3	-0.7	-1.1
Medication: Blood pressure	0.3	0.7	1.5	1.2	-1.2	0.5	0.6	-0.3	-0.7	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.9	-0.1	0.2	0.6	0.6	-0.3	-0.7	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.1	-0.2	-0.3	1.1	0.9	-0.5	0.5	1.0
High cholesterol (Self-reported)	2.5	4.4	9.9	3.1	-2.5	1.7	1.7	1.8	1.4	1.7
Medication: Bendroflumethiazide	0.2	0.3	0.9	0.3	0.2	0.0	-0.2	-0.9	-0.6	0.8
Medication: Paracetamol	0.3	0.4	1.5	-1.2	0.2	-0.6	-0.5	-0.4	-0.4	0.6
Medication: Lisinopril	2.4	3.1	7.1	-1.5	1.6	-1.3	-1.6	-2.7	-2.0	-1.2
Medication: Atorvastatin	2.8	3.5	11.1	3.3	-1.7	1.6	1.4	1.8	0.7	1.6
Illnesses of father: High blood pressure	0.3	0.4	1.0	0.3	-0.6	0.5	0.4	1.0	0.5	0.7
Alcohol drinker status: Never	2.3	2.8	4.4	-0.7	1.7	-1.9	-1.7	-1.4	-1.8	-2.1
Ever smoked	0.2	0.3	1.5	0.5	0.2	0.8	0.3	0.0	0.1	1.2
Basal metabolic rate	0.6	3.4	19.2	0.3	0.9	1.6	0.7	-0.2	-0.7	4.4
Leg fat percentage (left)	0.6	2.3	8.8	3.0	-0.5	0.6	0.6	0.3	-0.6	2.4
Arm fat-free mass (left)	0.7	3.3	17.2	0.3	1.0	1.9	0.9	0.2	-0.6	4.2
Number of operations (self-reported)	0.6	0.8	1.8	-1.2	0.1	-0.5	-0.3	-1.2	-1.0	-1.3
Average weekly beer plus cider intake	0.3	0.5	1.8	0.5	0.3	-0.8	-0.4	-0.6	-1.4	-0.4
Irritability	0.4	0.7	2.7	1.6	-0.6	0.3	0.6	0.3	-0.9	-0.6
Risk taking	0.5	0.7	2.6	0.4	-1.6	0.2	0.5	0.9	0.9	0.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.9	-1.7	0.4	-0.5	-0.5	-1.0	-0.6	-0.9
Fractured/broken bones in last 5 years	1.9	2.5	8.9	1.4	-3.0	-1.0	0.6	0.3	-0.2	-2.3
Age started oral contraceptive pill	0.7	0.8	1.5	1.2	-0.8	1.0	0.9	0.5	0.3	1.2
Diastolic blood pressure, automated reading	0.8	2.5	6.2	-0.5	1.1	-1.9	-1.8	-1.8	-2.5	0.1
Ever depressed for a whole week	0.4	0.5	0.9	0.4	0.3	0.8	0.6	0.9	-0.6	1.0
Unable to work because of sickness or disability	1.4	1.8	3.7	-1.4	0.7	-1.9	-1.1	-1.9	-0.8	-1.1
Commuting to job workplace: Cycle	3.1	3.7	10.6	3.3	-1.3	2.0	2.0	1.4	0.6	1.8
Myopia	0.4	0.5	2.1	0.5	-1.5	-0.5	0.2	-0.0	-0.1	-0.9
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.9	-1.5	-0.1	-0.8	-0.4	1.1	1.0	-1.7
Cholesterol lowering medication	5.0	7.4	10.8	3.3	-3.2	2.2	2.3	2.9	2.6	2.2
Medication: Omeprazole (e.g. Zanprol)	2.1	2.6	4.6	-0.1	1.6	-2.1	-1.8	-1.6	-2.0	-1.1
Pain experienced in last month	0.7	1.2	4.1	2.0	-1.0	-1.2	-0.6	-0.0	0.1	-1.2
Supplements: Calcium	3.6	4.0	11.6	1.1	-3.4	1.3	2.2	1.9	2.1	-0.0
Basal cell carcinoma (self-reported)	0.4	0.4	1.8	0.1	-1.0	-0.4	-0.2	0.3	0.1	-1.4
Heart attack/myocardial infarction (self-reported)	4.4	5.6	12.6	3.5	-3.3	2.0	2.2	1.5	1.5	1.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-0.6	1.1	-0.6	-0.5	-1.0	0.1	0.1
Heart disease (siblings)	0.1	0.2	0.8	0.1	-0.2	-0.2	0.1	-0.5	-0.2	0.9
Alcohol drinker status: Previous	0.4	0.5	3.0	0.3	-0.0	-0.3	0.0	-1.7	-0.4	-0.1
Pack years of smoking	0.6	0.8	2.0	1.0	-1.4	0.5	0.9	1.1	0.4	0.6
Impedance of whole body	0.6	2.8	7.0	1.4	-2.3	-0.1	0.8	1.4	2.6	-1.7
Leg fat mass (left)	0.6	2.5	10.6	2.3	0.0	0.7	0.5	-0.2	-0.9	3.3
Arm predicted mass (left)	0.7	3.7	18.7	0.5	1.0	2.1	1.1	0.0	-0.6	4.3