Hub : Genes

CWC27

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.074 0.028 4.8e-04 0.034 0.022 0.029 0.028 0.031 4.8e-05 0.00087 1.8e-04 2e-04 9.4e-05
2 GTEx Testis 0.179 0.051 1.6e-05 0.191 NA 0.203 NA 0.199 6.9e-09 NA 2.1e-09 NA 3.3e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.4 0.6 0.8 0.7 -0.9
Bipolar Disorder or Schizophrenia 1.0 2.4 2.8 1.4 -1.7
Depressed Affect (Nagel 2018) 2.7 5.8 6.4 2.5 -2.3
Depression (Nagel 2018) 2.1 3.1 3.9 2.0 -1.5
Intelligence (Savage-Jansen 2018) 0.0 0.0 0.0 -0.2 0.1
Neuroticism (Nagel 2018) 6.5 15.3 15.4 3.9 -3.9
Schizophrenia (2018) 0.9 1.9 2.1 1.3 -1.4
Schizophrenia vs Biploar Disorder 0.0 0.0 0.1 -0.1 0.2
Worry (Nagel 2018) 3.2 6.7 6.9 2.5 -2.6
Alzheimer’s Disease (in mother) 0.9 1.1 1.3 1.1 -0.9
Alzheimer’s Disease (in father) 0.6 0.6 0.9 0.9 -0.6
Alzheimer’s Disease (including proxy) 1.6 2.3 2.5 1.6 -1.4
Crohns Disease (2017) 0.0 0.0 0.1 0.0 0.3
Irritable Bowel Disease (IBD) 0.5 1.2 1.3 1.1 -1.1
Ulcerative Colitis (UC) 1.7 3.1 3.4 1.7 -1.8
Major Depression (MDD) 0.0 0.0 0.1 0.1 0.3
Reaction Time 3.4 6.5 7.1 -2.4 2.7
Verbal and Numeric Reasoning (VNR) 0.3 0.7 0.7 0.8 -0.8
Breast Cancer 0.6 1.5 2.0 1.4 -1.0
Ovarian Cancer 2.7 3.6 4.2 -1.8 2.0
Prostate Cancer 0.1 0.1 0.3 -0.5 0.1
Age at First Birth 1.4 2.0 2.3 1.5 -1.3
Bipolar Disorder (2011) 0.3 0.3 0.4 0.6 -0.5
Body Mass Index (BMI) (2010) 1.2 1.7 1.9 1.4 -1.2
Coronary Artery Disease (CAD) 0.2 0.3 0.3 0.6 -0.4
Crohns Disease (2012) 0.2 0.3 0.3 -0.6 0.5
Mean Putamen Volume 0.0 0.0 0.0 -0.1 0.2
Fasting Glucose 0.5 0.5 0.7 -0.8 0.6
HbA1C 0.1 0.1 0.1 -0.2 0.3
HDL Cholesterol 0.0 0.0 0.0 -0.0 -0.1
LDL Cholesterol 0.3 0.4 0.6 0.8 -0.5
Lupus 0.2 0.3 0.6 -0.8 0.3
Neuroticism (2016) 0.9 1.3 1.4 1.1 -1.2
Primary Biliary Cirrhosis 1.4 2.0 2.2 1.5 -1.3
Rheumatoid Arthritis 0.2 0.3 0.4 0.6 -0.5
Schizophrenia (2014) 1.6 3.6 4.2 1.7 -2.1
Triglycerides 0.8 1.3 1.4 1.2 -1.1
Type 2 Diabetes (T2D) (2012) 1.3 1.5 1.7 1.1 -1.3
Ulcerative Colitis 0.3 0.5 0.6 0.6 -0.8
Blood Eosinophil Count 0.1 0.8 0.9 0.9 -0.9
Blood Platelet Count 0.2 2.5 2.9 1.4 -1.7
Blood Red Count 0.2 1.9 2.0 1.3 -1.4
Blood White Count 0.4 2.8 3.2 1.6 -1.8
Heel T-Score 0.1 0.8 1.1 0.7 -1.1
BMI 4.7 27.4 28.0 5.2 -5.3
Height 0.2 3.3 4.3 -2.1 1.5
Waist Hip Ratio (WHR) 0.1 0.6 1.0 -0.5 1.0
Systolic Blood Pressure 2.0 10.2 11.9 -3.4 2.9
Smoking Status 0.0 0.0 0.0 0.2 -0.1
Allergy or Eczema 0.8 2.2 2.3 -1.4 1.5
Cardiovascular Disease 0.4 1.2 1.7 0.8 -1.3
Hypothyroidism (self reported) 0.9 2.0 2.5 1.6 -1.2
Respiratory disease 2.2 5.0 5.8 2.4 -2.0
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.3 0.7 -1.1
Lung FEV1/FVC ratio 2.5 12.5 13.5 -3.7 3.4
Lung FVC 0.2 0.9 1.3 -1.1 0.8
Neuroticism 1.9 4.6 4.6 2.1 -2.1
Chronotype (morning person) 5.4 12.4 12.6 -3.5 3.5
Hair Pigment 0.0 0.2 0.3 0.5 -0.3
Tanning 0.6 6.8 7.6 -2.8 2.5
Hand grip strength (left) 1.7 4.6 5.2 2.0 -2.3
Number of treatments/medications taken 0.7 1.3 1.7 1.0 -1.3
Average weekly spirits intake 0.1 0.1 0.3 0.5 -0.1
Sensitivity / hurt feelings 7.5 12.9 13.0 3.6 -3.6
Frequency of depressed mood in last 2 weeks 5.5 7.7 8.4 2.9 -2.7
Hearing difficulty/problems: Yes 0.9 1.4 1.7 -1.0 1.3
Relative age of first facial hair 2.1 4.2 5.0 -1.9 2.2
Other serious medical condition/disability diagnosed by doctor 2.9 3.8 4.3 2.1 -1.8
Ever used hormone-replacement therapy (HRT) 0.5 0.7 0.9 0.7 -1.0
Ever had hysterectomy (womb removed) 0.0 0.0 0.0 0.1 -0.0
Systolic blood pressure, automated reading 2.0 5.8 7.1 -2.7 2.1
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 1.7 -1.3 1.0
Angina 1.1 1.4 1.6 1.3 -1.1
Medication for hormone replacement therapy 2.0 2.2 2.4 1.4 -1.5
Vitamin and mineral supplements 1.8 2.5 2.8 -1.5 1.7
Supplements: Zinc 3.3 3.6 4.6 -1.6 2.1
Medication: Co-codamol 0.7 0.8 0.9 0.9 -0.8
Medication: Metformin 0.2 0.3 0.4 -0.7 0.4
Diabetes (father) 2.4 2.9 3.2 1.6 -1.8
Diabetes (mother) 0.2 0.3 0.4 -0.5 0.6
Severe depression (siblings) 0.6 0.7 0.7 0.9 -0.8
Pack years adult smoking proportion 0.1 0.1 0.2 -0.2 0.4
Impedance of leg (right) 3.3 15.9 17.7 -3.8 4.2
Leg fat-free mass (left) 2.1 11.1 13.0 3.0 -3.6
Trunk fat percentage 2.9 11.5 12.4 3.5 -3.2
Hand grip strength (right) 1.2 3.3 3.6 1.7 -1.9
Townsend deprivation index at recruitment 0.7 1.0 1.2 -0.9 1.1
Current tobacco smoking 0.0 0.0 0.0 0.2 0.2
Average weekly fortified wine intake 0.0 0.0 0.1 0.2 -0.1
Maternal smoking around birth 1.2 1.7 1.7 1.3 -1.3
Fed-up feelings 1.3 2.4 2.9 1.7 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.9 1.3 1.1 -0.7
Relative age voice broke 0.0 0.0 0.0 0.2 0.2
Taking other prescription medications 2.0 3.0 3.4 1.6 -1.8
Age when periods started (menarche) 0.1 0.3 0.4 0.7 -0.4
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 1.6 1.1 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 -0.6 0.5
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.0 0.7 -1.0
Qualifications: CSEs or equivalent 3.6 4.7 5.5 2.0 -2.4
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.3 0.4
High blood pressure 0.0 0.1 0.1 -0.1 -0.3
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 -0.2 0.3
Multivitamins +/- minerals 0.5 0.7 0.9 0.7 -0.9
Stomach or abdominal pain in last month 2.7 3.4 4.2 2.0 -1.6
Supplements: Glucosamine 1.7 2.2 3.2 1.1 -1.8
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.0 -0.9 1.0
Medication: Atenolol 0.5 0.6 1.0 0.5 -1.0
Medication: Levothyroxine sodium 0.1 0.2 0.3 -0.3 0.6
Sitting height 0.1 0.6 1.0 -1.0 0.5
Chronic bronchitis/emphysema (father) 1.6 1.9 2.5 1.6 -1.2
High blood pressure (mother) 0.1 0.1 0.1 -0.4 0.1
Body mass index (BMI) 3.4 14.4 15.0 3.7 -3.9
Impedance of leg (left) 2.1 10.0 12.0 -2.8 3.5
Leg predicted mass (left) 2.1 11.3 13.3 3.1 -3.6
Trunk fat mass 3.0 12.9 13.0 3.6 -3.6
Waist circumference 1.7 6.3 6.5 2.5 -2.5
Number of incorrect matches in round 0.1 0.2 0.3 -0.6 0.1
Past tobacco smoking 0.1 0.2 0.2 0.3 -0.5
Alcohol usually taken with meals 4.8 7.8 7.9 -2.8 2.8
Nervous feelings 4.3 7.9 8.5 2.9 -2.7
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.4 2.5 1.5 -1.6
Hearing difficulty/problems with background noise 0.4 0.7 1.2 -0.4 1.1
Hair/balding pattern: Pattern 2 4.0 5.1 5.3 2.2 -2.3
Had menopause 0.6 0.8 0.8 -0.9 0.9
Had other major operations 2.3 2.8 2.9 1.7 -1.6
Forced vital capacity (FVC) 0.1 0.2 0.4 -0.6 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 0.6 -0.8 0.7
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 1.9 1.4 -1.2
Qualifications: None of the above 0.3 0.7 0.9 -0.7 0.9
Financial difficulties in last 2 years 5.1 6.9 7.3 2.7 -2.5
Mouth/teeth dental problems 0.0 0.1 0.1 0.1 -0.4
Heart attack 2.9 3.7 4.1 2.0 -1.8
Allergy 0.7 1.5 1.7 -1.3 1.1
Pain all over the body in last month 1.8 2.0 2.3 1.5 -1.3
Diabetes (self-reported) 0.3 0.4 0.5 -0.7 0.5
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 2.1 -1.2 1.4
Medication: Ramipril 0.0 0.1 0.1 0.3 -0.2
Medication: Simvastatin 0.5 0.7 1.1 -1.1 0.5
Fluid intelligence score 0.0 0.1 0.1 -0.3 0.3
Illnesses of siblings 2.0 2.8 2.9 1.7 -1.7
Neuroticism score 2.7 5.6 5.7 2.4 -2.3
Weight 2.2 11.0 12.1 3.1 -3.5
Impedance of arm (right) 0.8 3.9 5.0 -1.7 2.2
Arm fat percentage (right) 3.5 13.8 14.1 3.8 -3.7
Trunk fat-free mass 0.6 3.5 5.0 1.4 -2.2
Hip circumference 1.5 6.3 7.2 2.3 -2.7
Time employed in main current job 3.4 3.9 4.5 1.8 -2.1
Alcohol intake versus 10 years previously 1.4 2.1 2.4 1.4 -1.5
Father’s age at death 1.2 1.6 1.6 -1.3 1.2
Worrier / anxious feelings 1.8 3.5 3.6 1.8 -1.9
Frequency of tiredness / lethargy in last 2 weeks 3.6 5.9 7.0 2.6 -2.2
Falls in the last year 0.8 1.0 1.3 1.1 -0.9
Hair/balding pattern: Pattern 3 4.3 6.4 7.6 -2.3 2.8
Number of live births 0.0 0.1 0.1 -0.2 0.3
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.0 -1.4 0.9
Pulse rate 0.8 1.3 1.4 1.2 -1.1
Happiness 0.1 0.2 0.2 0.4 -0.4
Noisy workplace 0.3 0.4 0.5 0.6 -0.7
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.0 0.1 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.2 -0.5 0.5
Mouth/teeth dental problems: Dentures 0.1 0.2 0.2 -0.4 0.4
Asthma 2.7 5.3 6.3 2.5 -2.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.4 0.5 0.7 -0.6
Medication: Cholesterol lowering 1.5 2.3 3.0 -1.7 1.3
Depression (self-reported) 0.0 0.0 0.0 -0.1 0.2
Medication: Lansoprazole 0.1 0.1 0.2 -0.2 0.4
Prospective memory result 0.1 0.1 0.2 -0.1 0.4
Lung cancer (father) 0.1 0.1 0.1 -0.3 0.2
Illnesses of mother 0.0 0.0 0.1 0.3 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 1.7 -1.3 0.8
Pulse wave Arterial Stiffness index 0.0 0.0 0.0 0.1 -0.2
Impedance of arm (left) 0.3 1.5 2.1 -1.0 1.4
Arm fat mass (right) 3.4 14.1 14.5 3.7 -3.8
Trunk predicted mass 0.5 2.9 4.2 1.2 -2.0
Standing height 0.0 0.1 0.1 -0.4 -0.1
Length of working week for main job 0.2 0.2 0.3 0.3 -0.5
Exposure to tobacco smoke at home 1.2 1.4 1.5 -1.1 1.2
Breastfed as a baby 0.4 0.5 0.6 -0.7 0.8
Tense / ‘highly strung’ 6.3 10.5 10.6 3.2 -3.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 3.2 1.8 -1.6
Hair/balding pattern: Pattern 4 0.2 0.5 0.7 -0.8 0.4
Birth weight of first child 0.2 0.4 0.5 -0.7 0.6
Peak expiratory flow (PEF) 2.2 5.2 5.6 -2.4 2.2
Pulse wave reflection index 0.4 0.5 0.7 -0.5 0.8
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 0.1 -0.4
Loud music exposure frequency 0.5 0.6 0.7 -0.7 0.8
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 1.0 1.0 -1.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.1 -0.1 0.4
Blood clot in the leg (DVT) 0.7 1.0 1.0 1.0 -1.0
Medication: Paracetamol 1.6 2.7 2.8 1.7 -1.6
Headache pain in last month 0.7 1.1 1.3 1.1 -1.0
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.2 1.1 -0.7
Glaucoma (self-reported) 0.0 0.0 0.1 -0.3 -0.1
Gout (self-reported) 0.1 0.1 0.1 -0.2 0.3
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.1 0.3 -0.2
Medication: Amlodipine 0.1 0.1 0.1 -0.3 0.4
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.0 -0.1 0.2
Birth weight 0.1 0.2 0.4 0.3 -0.6
Chronic bronchitis/emphysema (mother) 0.6 0.7 0.8 0.9 -0.8
High blood pressure (siblings) 0.3 0.4 0.5 -0.7 0.7
Forced vital capacity (FVC), Best measure 0.2 0.6 0.9 -1.0 0.5
Body fat percentage 2.6 10.3 10.9 3.3 -3.1
Leg fat percentage (right) 1.3 4.6 4.7 2.1 -2.2
Arm fat-free mass (right) 1.2 6.0 7.7 2.1 -2.8
Exposure to tobacco smoke outside home 1.1 1.5 1.8 -1.1 1.3
Comparative body size at age 10 0.0 0.0 0.0 -0.0 -0.2
Number of full brothers 0.4 0.6 0.7 -0.6 0.8
Worry too long after embarrassment 2.8 4.7 4.9 2.2 -2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.0 2.5 1.6 -1.2
Wheeze or whistling in the chest in last year 1.5 2.7 3.5 1.9 -1.4
Number of children fathered 0.0 0.0 0.0 -0.0 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.4 -0.6 0.3
Age at first live birth 0.4 0.6 1.0 1.0 -0.6
Pulse wave peak to peak time 0.1 0.2 0.2 -0.4 0.4
Health satisfaction 4.9 6.4 6.7 2.6 -2.4
Shortness of breath walking on level ground 0.9 1.1 1.4 1.2 -0.9
Qualifications: College or University degree 0.1 0.4 0.5 -0.7 0.6
Eye problems/disorders: None of the above 0.7 0.8 1.0 1.0 -0.7
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.8 0.9 -0.4
Emphysema/chronic bronchitis 0.2 0.3 0.3 -0.6 0.5
Medication for pain relief, constipation, heartburn 1.3 2.1 2.2 -1.5 1.5
Neck or shoulder pain in last month 0.3 0.4 0.4 0.6 -0.6
Medication: Blood pressure 0.0 0.0 0.0 -0.1 -0.1
Angina (self-reported) 1.3 1.7 2.0 1.4 -1.2
Migraine (self-reported) 0.0 0.0 0.0 0.1 -0.2
Medication: Ibuprofen 0.1 0.1 0.2 0.4 -0.3
Medication: Allopurinol 0.5 0.6 0.8 -0.7 0.9
Medication: Omeprazole 0.0 0.0 0.1 -0.1 -0.3
Medication: Seretide 50 evohaler 1.7 2.0 2.0 1.4 -1.4
Mean time to correctly identify matches 3.8 7.3 8.1 -2.6 2.8
Heart disease (mother) 0.7 0.9 1.2 0.7 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.2 -0.7 1.1
Whole body fat mass 2.9 12.1 12.2 3.5 -3.5
Leg fat mass (right) 2.1 8.3 8.9 2.8 -3.0
Arm predicted mass (right) 1.3 6.7 8.4 2.2 -2.9
Pulse rate, automated reading 0.2 0.7 0.9 0.8 -1.0
Alcohol intake frequency. 0.3 0.8 0.9 0.8 -1.0
Comparative height size at age 10 0.1 0.4 0.7 0.4 -0.8
Number of full sisters 0.0 0.0 0.1 0.2 0.1
Suffer from ‘nerves’ 0.8 1.2 1.4 1.2 -1.0
Overall health rating 3.9 8.4 9.1 3.0 -2.8
Chest pain or discomfort 3.2 4.6 4.9 2.2 -2.1
Had major operations 0.0 0.0 0.0 -0.0 0.0
Age at last live birth 0.4 0.6 0.9 1.0 -0.4
Family relationship satisfaction 0.0 0.0 0.1 -0.1 -0.3
Leg pain on walking 6.3 7.9 8.2 2.9 -2.8
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 1.0 -0.9 1.0
Commuting to job workplace: Car/motor vehicle 2.7 3.1 3.3 1.7 -1.8
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 1.4 -1.2 1.0
Medication: Aspirin 0.1 0.1 0.1 0.3 -0.4
Supplements: Vitamin C 1.0 1.2 1.4 1.2 -1.0
Knee pain experienced in last month 2.5 3.8 4.2 2.0 -1.9
Hypertension (Self-reported) 0.0 0.0 0.1 -0.2 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.0 -0.8 1.0
Illnesses of father: Heart disease 1.7 2.4 2.5 1.5 -1.6
Illnesses of siblings: Diabetes 0.0 0.1 0.1 -0.1 0.3
Smoking status: Previous 0.0 0.0 0.0 -0.1 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.2 -0.5 0.3
Whole body fat-free mass 1.2 6.9 8.8 2.2 -3.0
Leg fat-free mass (right) 2.6 13.9 15.9 3.5 -4.0
Arm fat percentage (left) 4.2 16.6 16.8 4.1 -4.0
Average weekly red wine intake 1.7 2.5 2.8 -1.7 1.5
Handedness (chirality/laterality): Left-handed 0.9 1.1 1.2 1.0 -1.1
Mood swings 2.1 3.8 4.1 2.0 -1.8
Loneliness, isolation 5.7 7.9 9.1 3.0 -2.6
Long-standing illness, disability or infirmity 4.2 6.4 6.7 2.6 -2.5
Ever had bowel cancer screening 2.6 3.0 3.3 1.8 -1.6
Diabetes diagnosed by doctor 0.1 0.2 0.3 -0.6 0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 1.9 1.4 -1.3
Friendships satisfaction 0.0 0.0 0.0 0.2 -0.1
Qualifications: nursing, teaching 0.2 0.3 0.4 0.4 -0.6
Commuting to job workplace: Walk 0.7 0.7 0.7 -0.8 0.8
Eye problems/disorders: Cataract 0.5 0.6 0.9 -1.0 0.5
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 0.8 0.9 -0.6
Medication for cholesterol 0.7 1.0 1.5 -0.7 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 1.2 -1.1 1.1
Back pain experienced in last month 3.5 5.1 5.3 2.2 -2.3
Mineral and other dietary supplements 0.4 0.6 0.9 0.9 -0.6
Breast cancer (self-reported) 0.1 0.1 0.2 0.2 -0.4
Asthma (self-reported) 2.7 5.4 6.5 2.5 -2.1
Osteoporosis (self-reported) 0.0 0.0 0.0 -0.0 0.1
Osteoarthritis (self-reported) 1.8 2.4 2.5 1.5 -1.6
Medication: Aspirin 0.0 0.0 0.0 -0.1 -0.1
Medication: Gliclazide 0.0 0.0 0.0 -0.1 0.0
Illnesses of father: None of the above (group 1) 8.1 10.0 10.5 -3.2 3.1
Smoking status: Current 0.0 0.1 0.1 0.3 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.1 -0.4 -0.0
Whole body water mass 1.2 6.6 8.5 2.2 -2.9
Leg predicted mass (right) 2.6 14.0 16.1 3.5 -4.0
Arm fat mass (left) 3.8 15.5 15.9 3.9 -4.0
Number of self-reported non-cancer illnesses 4.2 7.4 7.5 2.7 -2.7
Average weekly champagne plus white wine intake 0.6 0.8 0.8 -0.9 0.9
Miserableness 0.7 1.2 1.5 1.2 -1.0
Guilty feelings 6.2 9.3 9.6 3.1 -3.0
Wears glasses or contact lenses 0.8 1.0 1.3 -0.8 1.1
Ever taken oral contraceptive pill 0.0 0.0 0.0 -0.0 0.0
Hearing aid user 2.3 2.6 2.9 1.7 -1.5
Mother’s age at death 1.1 1.3 1.5 -1.2 1.1
Financial situation satisfaction 0.1 0.1 0.2 -0.2 0.5
Tinnitus: Yes, now most or all of the time 1.7 1.9 2.0 1.4 -1.4
Commuting to job workplace: Public transport 1.0 1.2 1.4 1.2 -1.0
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 -0.5 0.1
Medication: Blood pressure 0.6 1.2 1.7 0.8 -1.3
Pain type(s) experienced in last month: Hip pain 3.2 4.0 4.1 2.0 -2.0
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.2 -0.5 0.2
High cholesterol (Self-reported) 0.1 0.2 0.3 -0.6 0.2
Medication: Bendroflumethiazide 0.8 1.2 1.9 -1.4 0.7
Medication: Paracetamol 1.8 2.9 3.1 1.8 -1.6
Medication: Lisinopril 0.6 0.8 1.0 0.8 -1.0
Medication: Atorvastatin 0.1 0.1 0.1 0.2 -0.4
Illnesses of father: High blood pressure 1.2 1.5 1.6 1.2 -1.3
Alcohol drinker status: Never 0.1 0.1 0.1 0.4 -0.2
Ever smoked 0.3 0.5 0.7 -0.5 0.8
Basal metabolic rate 1.5 8.5 10.3 2.6 -3.2
Leg fat percentage (left) 2.2 8.0 8.2 2.9 -2.8
Arm fat-free mass (left) 0.9 4.4 5.8 1.7 -2.4
Number of operations (self-reported) 0.3 0.5 0.7 0.8 -0.5
Average weekly beer plus cider intake 3.4 4.9 5.0 2.2 -2.2
Irritability 3.3 5.6 5.8 2.3 -2.4
Risk taking 4.4 6.4 6.7 2.6 -2.5
Ever had prostate specific antigen (PSA) test 1.6 1.9 2.3 -1.5 1.2
Fractured/broken bones in last 5 years 1.6 2.0 2.2 1.5 -1.4
Age started oral contraceptive pill 0.7 0.8 0.9 -0.9 0.9
Diastolic blood pressure, automated reading 0.1 0.2 0.4 -0.6 0.2
Ever depressed for a whole week 0.0 0.0 0.0 -0.1 0.0
Unable to work because of sickness or disability 0.2 0.3 0.5 0.7 -0.4
Commuting to job workplace: Cycle 1.3 1.6 1.7 -1.3 1.3
Myopia 0.9 1.3 1.8 1.3 -0.9
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.6 -0.3 0.8
Cholesterol lowering medication 0.3 0.5 0.6 0.5 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.3 0.2 -0.5
Pain experienced in last month 4.8 8.1 8.4 -2.9 2.8
Supplements: Calcium 0.0 0.0 0.0 -0.1 -0.1
Basal cell carcinoma (self-reported) 1.6 1.9 2.5 -1.6 1.2
Heart attack/myocardial infarction (self-reported) 3.0 3.8 4.0 2.0 -1.9
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.4 0.6 -0.6
Heart disease (siblings) 1.3 1.6 1.6 -1.3 1.2
Alcohol drinker status: Previous 0.0 0.0 0.1 -0.2 -0.2
Pack years of smoking 0.4 0.6 0.7 -0.7 0.8
Impedance of whole body 1.1 5.4 6.9 -2.0 2.6
Leg fat mass (left) 2.9 11.3 11.6 3.3 -3.4
Arm predicted mass (left) 0.9 4.4 5.8 1.7 -2.4