Hub : Genes

CXCL12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.138	0.0560	7.3e-03	0.035	NA	0.025	NA	0.024	6.4e-03	NA	1.9e-02	NA	2.0e-02
2	GTEx	Breast Mammary Tissue (Female)	0.357	0.1012	1.6e-03	0.049	NA	0.081	NA	0.063	1.4e-02	NA	2.1e-03	NA	6.1e-03
3	GTEx	Pancreas	0.316	0.0750	4.2e-06	0.202	NA	0.220	NA	0.219	5.8e-09	NA	1.1e-09	NA	1.2e-09
4	TCGA	Breast Invasive Carcinoma	0.026	0.0116	1.6e-03	0.000	0.015	0.004	NA	0.003	3.2e-01	0.00041	3.9e-02	NA	7.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.7	1.9	-0.0	0.5	-0.9	1.4
Bipolar Disorder or Schizophrenia	1.0	2.4	5.8	2.4	1.6	-0.6	-1.0
Depressed Affect (Nagel 2018)	2.5	5.4	11.4	-3.4	-2.9	1.1	-0.4
Depression (Nagel 2018)	1.1	1.6	3.7	-0.8	-1.9	-0.5	-1.3
Intelligence (Savage-Jansen 2018)	0.5	1.5	5.2	0.4	0.1	2.3	0.8
Neuroticism (Nagel 2018)	1.7	3.9	11.4	-3.4	-2.1	0.1	-0.3
Schizophrenia (2018)	2.2	4.5	9.6	3.1	1.6	-0.0	-2.4
Schizophrenia vs Biploar Disorder	0.3	0.3	0.8	0.1	-0.6	-0.3	-0.9
Worry (Nagel 2018)	1.0	2.0	5.6	-2.4	-1.3	-0.9	-0.1
Alzheimer’s Disease (in mother)	0.5	0.5	1.6	0.4	-0.4	-0.5	-1.3
Alzheimer’s Disease (in father)	0.6	0.6	1.2	1.1	0.3	1.0	0.2
Alzheimer’s Disease (including proxy)	0.8	1.2	2.3	1.4	0.1	0.6	-1.5
Crohns Disease (2017)	0.7	1.6	2.9	-1.5	-1.7	0.9	0.6
Irritable Bowel Disease (IBD)	0.4	1.0	2.5	-1.1	-1.6	-0.5	0.3
Ulcerative Colitis (UC)	0.5	1.0	2.7	-0.3	-1.1	-1.6	0.3
Major Depression (MDD)	0.1	0.1	0.4	0.3	0.6	-0.2	0.2
Reaction Time	1.5	2.9	4.4	1.5	2.1	1.5	-1.6
Verbal and Numeric Reasoning (VNR)	0.6	1.3	4.3	0.4	0.7	2.1	0.6
Breast Cancer	0.2	0.4	1.4	1.2	-0.2	-0.1	0.5
Ovarian Cancer	0.4	0.5	1.7	1.3	0.2	0.0	-0.5
Prostate Cancer	1.4	2.0	4.0	0.0	-1.4	-1.4	2.0
Age at First Birth	0.4	0.6	0.8	-0.8	-0.9	0.5	0.8
Bipolar Disorder (2011)	1.3	1.3	2.4	0.7	1.1	-1.5	1.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.1	1.4	0.6	0.3	-0.4
Coronary Artery Disease (CAD)	0.8	1.0	3.4	-1.8	-0.1	0.7	-0.3
Crohns Disease (2012)	0.7	1.1	1.6	-1.3	-1.0	1.2	-0.5
Mean Putamen Volume	1.5	1.7	6.0	0.5	-0.5	-2.4	0.6
Fasting Glucose	0.5	0.6	1.3	-0.2	0.9	-0.5	-1.1
HbA1C	0.8	0.9	2.4	-1.6	-0.7	0.3	-0.8
HDL Cholesterol	0.8	1.4	2.4	1.0	0.9	1.5	-1.1
LDL Cholesterol	0.5	0.8	2.3	0.0	-0.2	0.8	-1.5
Lupus	0.1	0.2	0.4	-0.4	-0.6	-0.1	0.3
Neuroticism (2016)	2.7	3.8	7.0	-2.6	-1.5	-2.1	-1.2
Primary Biliary Cirrhosis	1.6	2.2	5.3	2.3	1.3	-1.0	1.0
Rheumatoid Arthritis	0.2	0.2	0.6	0.6	0.1	0.8	0.0
Schizophrenia (2014)	1.6	3.5	9.2	3.0	1.6	-0.6	-1.3
Triglycerides	0.2	0.4	0.5	-0.6	-0.6	-0.7	-0.5
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.4	-0.8	-0.3	-1.8	0.1
Ulcerative Colitis	0.5	0.8	1.7	-0.6	-1.1	-1.3	0.2
Blood Eosinophil Count	2.0	15.5	53.0	-0.1	-1.0	-2.9	7.3
Blood Platelet Count	0.3	3.2	5.8	-2.4	-2.0	0.4	1.7
Blood Red Count	0.7	6.5	12.2	3.5	-0.4	-1.5	-3.4
Blood White Count	2.8	20.7	59.1	1.3	-1.0	-4.6	7.7
Heel T-Score	0.0	0.3	1.1	-0.4	-1.0	0.3	0.1
BMI	0.2	1.1	2.1	0.8	1.3	-1.4	0.0
Height	0.2	3.8	8.8	3.0	2.2	1.2	0.2
Waist Hip Ratio (WHR)	0.7	3.1	5.2	-2.3	-1.8	1.2	1.5
Systolic Blood Pressure	0.3	1.5	3.5	-0.3	-1.5	0.5	1.9
Smoking Status	0.6	1.4	2.6	-0.8	-1.3	0.6	1.6
Allergy or Eczema	0.5	1.4	3.9	0.9	0.9	2.0	0.3
Cardiovascular Disease	0.5	1.8	6.5	0.6	-0.6	0.3	2.5
Hypothyroidism (self reported)	1.5	3.3	9.9	-3.1	-1.6	-0.7	0.5
Respiratory disease	1.8	4.0	8.3	-2.2	-1.3	-2.9	-1.0
Type 2 Diabetes (T2D) (2018)	0.9	1.6	5.1	0.8	0.5	2.3	0.6
Lung FEV1/FVC ratio	0.3	1.4	2.8	-1.0	-1.7	0.6	1.1
Lung FVC	0.4	2.2	4.9	1.7	1.0	2.2	0.2
Neuroticism	1.2	2.8	5.6	-2.4	-2.3	-0.2	0.4
Chronotype (morning person)	0.5	1.1	3.8	1.9	0.7	-0.3	-0.0
Hair Pigment	0.0	0.4	0.7	-0.7	0.2	0.6	-0.8
Tanning	0.0	0.6	1.2	0.9	1.1	-0.4	-0.2
Hand grip strength (left)	0.4	1.0	3.3	0.8	1.8	-0.1	-0.4
Number of treatments/medications taken	0.3	0.5	1.4	0.5	-0.1	1.2	0.7
Average weekly spirits intake	0.4	0.5	1.8	1.3	0.4	0.1	0.2
Sensitivity / hurt feelings	0.7	1.3	1.9	-1.4	-1.2	0.3	1.2
Frequency of depressed mood in last 2 weeks	1.9	2.7	5.7	-2.2	-2.4	0.3	-0.1
Hearing difficulty/problems: Yes	0.8	1.2	3.0	-1.0	-0.6	-1.7	-0.6
Relative age of first facial hair	0.7	1.5	2.9	-1.7	-0.7	0.3	-1.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	0.5	0.0	0.4	0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.0	1.4	0.7	0.3	0.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.1	0.9	0.3	-1.2
Systolic blood pressure, automated reading	0.6	1.7	5.2	2.3	0.9	0.9	0.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.3	-0.6	-0.9	1.2	0.2
Angina	2.2	2.9	5.4	-2.0	-2.3	1.3	0.6
Medication for hormone replacement therapy	0.2	0.2	0.5	0.7	0.0	0.3	-0.6
Vitamin and mineral supplements	1.7	2.3	6.0	-2.5	-1.8	-0.5	-0.1
Supplements: Zinc	1.0	1.1	3.8	0.4	0.2	0.6	2.0
Medication: Co-codamol	0.5	0.6	1.5	0.1	-0.5	-0.8	1.2
Medication: Metformin	0.2	0.3	0.7	0.6	0.0	0.8	0.1
Diabetes (father)	0.8	1.0	1.4	0.9	1.0	-1.2	0.9
Diabetes (mother)	0.4	0.5	1.5	0.4	1.2	-0.5	-0.4
Severe depression (siblings)	0.7	0.7	1.3	1.2	0.8	0.4	0.9
Pack years adult smoking proportion	1.1	1.6	4.1	1.4	0.6	0.3	2.0
Impedance of leg (right)	0.6	3.1	6.2	-1.2	-2.2	-2.5	0.1
Leg fat-free mass (left)	0.7	3.6	7.7	2.1	2.8	1.4	0.1
Trunk fat percentage	0.1	0.5	1.2	-0.5	0.7	-1.1	-0.4
Hand grip strength (right)	0.2	0.5	1.5	0.5	1.2	0.1	-0.3
Townsend deprivation index at recruitment	0.8	1.1	2.7	1.6	0.8	-0.6	-0.9
Current tobacco smoking	1.8	2.9	8.4	-0.0	-1.2	1.3	2.9
Average weekly fortified wine intake	0.8	0.9	1.6	0.8	1.2	0.4	-1.2
Maternal smoking around birth	0.6	0.9	1.9	-1.0	-0.6	-1.4	-0.7
Fed-up feelings	0.4	0.7	0.8	-0.9	-0.8	0.9	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	2.3	-0.6	-1.5	-1.3	-0.5
Relative age voice broke	0.6	0.9	2.4	-1.6	-1.1	-0.1	-0.4
Taking other prescription medications	0.7	1.0	2.2	-0.7	-1.0	0.7	1.5
Age when periods started (menarche)	0.6	1.4	4.1	-0.4	-2.0	-0.6	0.9
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.9	1.1	0.5	-0.5	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.8	-0.0	0.3	0.9	-0.2
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	2.0	-0.7	0.9	-1.4	-1.3
Qualifications: CSEs or equivalent	1.4	1.9	3.3	-1.8	-1.5	-1.2	0.7
Serious illness, injury or assault to yourself	0.7	0.8	1.5	-0.4	-0.8	1.0	1.2
High blood pressure	0.3	0.8	1.8	1.4	-0.5	-0.1	1.1
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.2	0.8	1.3	2.0	0.0
Multivitamins +/- minerals	1.3	1.7	3.6	1.9	1.4	0.8	-0.8
Stomach or abdominal pain in last month	1.7	2.1	6.7	0.9	-0.0	-0.8	2.6
Supplements: Glucosamine	1.1	1.4	4.9	0.7	0.4	0.1	-2.2
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	5.3	-1.1	-2.3	0.4	2.1
Medication: Atenolol	1.5	1.9	2.8	-1.7	-1.7	-0.7	1.3
Medication: Levothyroxine sodium	0.7	1.2	2.6	-1.6	-1.3	0.5	-0.5
Sitting height	0.4	2.5	4.0	1.6	2.0	1.8	0.3
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	-0.4	-0.8	-0.6	0.9
High blood pressure (mother)	0.6	0.8	2.0	-0.8	-0.6	-0.3	1.4
Body mass index (BMI)	0.2	0.9	2.5	0.7	1.6	-0.6	-0.3
Impedance of leg (left)	0.9	4.3	6.8	-2.0	-2.6	-2.5	0.0
Leg predicted mass (left)	0.7	3.8	8.5	2.1	2.9	1.4	-0.1
Trunk fat mass	0.1	0.6	1.8	0.4	1.4	-0.4	-0.6
Waist circumference	0.2	0.6	1.8	0.1	1.4	0.1	-0.7
Number of incorrect matches in round	0.6	1.0	1.6	-0.6	-0.8	1.1	1.3
Past tobacco smoking	0.3	0.6	1.0	1.0	1.0	0.6	0.0
Alcohol usually taken with meals	1.5	2.4	6.4	-2.5	-1.1	1.3	-0.5
Nervous feelings	0.3	0.5	1.2	-1.1	-0.7	-0.5	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.6	-0.7	-0.8	-0.4	0.6
Hearing difficulty/problems with background noise	0.5	0.9	2.2	0.1	0.7	-1.5	-0.8
Hair/balding pattern: Pattern 2	0.1	0.2	0.6	0.3	0.7	0.3	0.0
Had menopause	1.7	2.2	4.2	1.1	2.0	1.8	0.2
Had other major operations	0.7	0.8	2.2	0.6	0.4	-0.7	1.5
Forced vital capacity (FVC)	0.7	2.5	7.2	1.0	1.2	2.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.6	0.1	0.8	1.2	-0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	-1.3	-0.6	0.3	0.4
Qualifications: None of the above	0.2	0.4	1.1	1.1	-0.4	0.6	0.2
Financial difficulties in last 2 years	1.8	2.4	5.9	-0.8	-2.4	-0.5	1.7
Mouth/teeth dental problems	1.3	2.0	4.2	-1.7	-0.6	-0.6	-2.0
Heart attack	0.6	0.7	2.3	-0.6	-0.2	1.5	-0.4
Allergy	0.4	0.9	3.0	-0.6	-1.7	0.1	0.5
Pain all over the body in last month	1.6	1.7	2.7	1.4	1.3	-0.5	1.6
Diabetes (self-reported)	0.6	0.9	3.4	-0.2	-0.4	1.9	0.3
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.1	0.1	0.4	0.1	0.2
Medication: Ramipril	0.6	0.8	1.4	1.0	-0.9	0.1	-1.2
Medication: Simvastatin	0.2	0.2	0.7	0.8	0.3	-0.0	-0.3
Fluid intelligence score	0.2	0.4	1.0	0.5	0.6	1.0	0.2
Illnesses of siblings	0.4	0.5	1.4	-1.2	-0.2	0.4	0.8
Neuroticism score	1.8	3.9	7.7	-2.8	-2.5	0.5	1.0
Weight	0.5	2.3	6.5	1.5	2.6	0.4	-0.6
Impedance of arm (right)	0.5	2.3	5.1	-2.3	-1.9	-0.4	-0.2
Arm fat percentage (right)	0.1	0.5	1.0	-0.4	0.8	-1.0	-0.5
Trunk fat-free mass	0.7	4.2	7.7	2.6	2.8	1.4	-0.6
Hip circumference	0.5	2.0	4.9	0.6	2.2	-0.1	-1.6
Time employed in main current job	0.7	0.8	1.8	0.6	1.0	1.3	0.2
Alcohol intake versus 10 years previously	1.2	1.8	2.6	-1.4	-1.5	0.6	1.6
Father’s age at death	0.5	0.7	1.9	-0.1	0.8	0.4	1.4
Worrier / anxious feelings	0.8	1.4	3.5	-1.1	-0.6	-1.9	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.5	1.7	1.1	1.3	1.3	-1.2
Falls in the last year	1.7	2.3	6.5	0.5	0.3	-2.5	1.5
Hair/balding pattern: Pattern 3	0.2	0.4	0.8	-0.8	0.2	0.1	-0.9
Number of live births	1.0	1.4	4.3	-0.2	-2.1	-1.0	0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.9	0.4	0.7	2.2	1.1
Pulse rate	0.6	1.1	2.3	0.6	-0.9	-1.5	0.9
Happiness	0.9	1.1	3.0	-0.2	-1.1	0.5	1.7
Noisy workplace	0.5	0.6	1.5	0.5	1.2	-0.8	-0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.6	-1.0	-0.5	-1.9	1.3
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.8	5.5	2.1	2.3	0.1	1.2
Mouth/teeth dental problems: Dentures	0.4	0.7	1.6	1.3	1.1	0.2	-0.3
Asthma	1.7	3.4	9.4	-0.8	0.2	-3.1	-1.9
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.2	0.7	1.1	1.7	-1.8
Medication: Cholesterol lowering	0.5	0.8	1.1	1.1	0.9	0.8	-0.7
Depression (self-reported)	1.2	1.4	2.9	-1.4	-0.7	1.7	-0.5
Medication: Lansoprazole	0.6	0.7	1.2	0.3	1.1	0.8	-0.9
Prospective memory result	0.1	0.2	0.3	0.6	0.3	0.5	-0.1
Lung cancer (father)	2.0	2.3	5.6	2.4	1.4	-0.2	1.2
Illnesses of mother	0.4	0.5	1.6	-0.1	-1.3	0.6	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	6.6	0.4	0.3	2.6	1.4
Pulse wave Arterial Stiffness index	0.7	0.8	1.4	0.9	1.0	1.2	0.2
Impedance of arm (left)	0.4	1.8	5.2	-2.3	-1.3	-0.3	-0.3
Arm fat mass (right)	0.2	0.9	2.5	0.3	1.6	-0.7	-0.6
Trunk predicted mass	0.8	4.3	7.8	2.6	2.8	1.4	-0.7
Standing height	0.4	3.5	5.4	1.9	2.2	2.3	-0.4
Length of working week for main job	0.5	0.5	1.9	1.4	0.1	0.4	0.1
Exposure to tobacco smoke at home	0.4	0.4	0.9	1.0	0.1	-0.8	0.2
Breastfed as a baby	1.3	1.6	3.4	1.8	1.0	-0.9	-1.0
Tense / ‘highly strung’	0.3	0.4	0.9	-0.9	-0.7	-0.6	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	6.3	-1.8	-0.4	0.5	2.5
Hair/balding pattern: Pattern 4	1.7	4.2	8.5	-2.0	-2.9	-0.3	2.1
Birth weight of first child	0.3	0.6	1.3	-0.1	-0.9	0.5	-1.2
Peak expiratory flow (PEF)	0.2	0.5	0.8	0.3	0.6	0.8	-0.9
Pulse wave reflection index	0.6	0.7	1.4	0.1	1.0	0.5	-1.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	-0.6	-0.2	-1.1	-0.1
Loud music exposure frequency	0.5	0.5	0.9	-0.9	-0.5	-0.9	0.4
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	2.2	1.1	1.4	-1.4	1.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.8	1.6	1.0	-0.3	1.7
Blood clot in the leg (DVT)	0.2	0.2	0.4	0.6	0.0	-0.7	-0.4
Medication: Paracetamol	0.4	0.7	1.5	0.6	1.0	1.2	-0.1
Headache pain in last month	0.6	1.0	1.6	-1.1	-1.3	0.8	0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.3	0.6	-0.3	-0.5
Glaucoma (self-reported)	0.3	0.4	0.7	0.5	0.9	0.7	0.1
Gout (self-reported)	3.2	4.4	8.5	2.9	2.1	-0.3	-2.2
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	6.6	-2.6	-1.2	-0.2	-0.4
Medication: Amlodipine	0.4	0.6	1.4	0.4	1.2	-0.6	0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	-0.3	-0.4	-1.2	0.4
Birth weight	0.4	0.9	3.0	-0.3	-0.2	0.8	-1.7
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.1	-1.8	0.2	-0.0	0.8
High blood pressure (siblings)	0.1	0.2	0.4	0.7	0.0	-0.4	-0.4
Forced vital capacity (FVC), Best measure	0.7	2.5	6.3	1.0	1.0	2.5	1.2
Body fat percentage	0.2	0.6	1.6	-0.3	0.6	-1.3	-0.7
Leg fat percentage (right)	0.3	1.1	3.9	0.3	0.5	-2.0	-0.6
Arm fat-free mass (right)	0.7	3.7	7.8	2.5	2.8	0.9	-0.3
Exposure to tobacco smoke outside home	0.5	0.7	1.4	-1.2	0.5	-1.0	-0.2
Comparative body size at age 10	0.4	1.2	2.7	1.0	1.6	0.9	0.6
Number of full brothers	0.5	0.7	1.5	0.7	-1.2	-0.5	0.7
Worry too long after embarrassment	0.5	0.8	1.8	-1.1	-1.3	-0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	2.5	-1.4	-1.6	0.6	1.3
Wheeze or whistling in the chest in last year	0.6	1.0	2.2	-0.2	0.4	-1.5	1.3
Number of children fathered	0.6	0.7	1.3	-1.1	0.3	-0.2	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.8	1.8	0.9	0.2	-1.9
Age at first live birth	0.2	0.4	1.1	-1.1	-0.6	0.1	0.2
Pulse wave peak to peak time	0.5	0.6	0.9	-0.9	-1.0	-0.8	-0.2
Health satisfaction	0.5	0.6	2.0	0.1	0.4	0.5	1.4
Shortness of breath walking on level ground	1.0	1.2	3.6	-0.9	-0.4	-1.9	0.1
Qualifications: College or University degree	0.5	1.4	3.7	-1.9	-0.2	0.5	1.3
Eye problems/disorders: None of the above	1.4	1.6	4.5	-2.1	-1.0	0.7	-0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	0.9	-0.3	-0.3	0.6
Emphysema/chronic bronchitis	1.6	1.9	4.2	1.3	0.6	-2.1	1.1
Medication for pain relief, constipation, heartburn	1.0	1.8	3.5	-0.6	-0.5	-1.9	1.7
Neck or shoulder pain in last month	0.4	0.6	1.8	0.7	-0.4	-1.4	0.3
Medication: Blood pressure	0.8	1.5	2.9	-1.5	-1.7	-0.7	0.4
Angina (self-reported)	2.2	2.8	5.4	-2.0	-2.3	1.3	0.7
Migraine (self-reported)	1.6	2.0	3.3	-1.5	-1.8	1.1	-1.1
Medication: Ibuprofen	1.7	2.1	4.0	0.4	1.0	1.8	-2.0
Medication: Allopurinol	0.8	1.0	1.8	1.3	0.8	0.1	-1.3
Medication: Omeprazole	0.7	0.8	2.5	-0.1	0.4	1.6	0.7
Medication: Seretide 50 evohaler	0.6	0.7	1.5	-1.1	0.2	-1.2	0.1
Mean time to correctly identify matches	1.6	3.0	4.4	1.4	1.8	1.6	-2.1
Heart disease (mother)	2.5	3.1	7.3	-2.7	-1.3	1.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.7	0.4	-0.2	0.3	0.8
Whole body fat mass	0.2	0.7	2.0	0.4	1.4	-0.5	-0.8
Leg fat mass (right)	0.3	1.0	1.6	0.9	1.3	-1.2	-0.5
Arm predicted mass (right)	0.7	3.4	7.2	2.5	2.7	0.6	-0.2
Pulse rate, automated reading	0.3	0.9	2.4	-0.7	-1.5	0.1	-0.8
Alcohol intake frequency.	0.4	0.9	2.4	-0.2	-1.5	0.6	0.8
Comparative height size at age 10	0.8	4.3	5.2	1.8	2.3	1.9	-2.2
Number of full sisters	0.8	0.9	1.7	1.1	0.8	-1.3	-0.5
Suffer from ‘nerves’	0.8	1.3	2.8	-1.0	0.7	0.9	1.7
Overall health rating	0.2	0.5	1.4	0.4	-0.0	-0.7	1.2
Chest pain or discomfort	0.2	0.2	0.6	0.8	0.0	-0.6	-0.1
Had major operations	2.5	2.9	5.0	2.2	1.2	1.5	1.7
Age at last live birth	0.4	0.6	2.0	-0.5	-1.4	0.4	-0.1
Family relationship satisfaction	1.3	1.6	3.0	1.7	-0.3	0.8	1.6
Leg pain on walking	0.4	0.5	1.5	-1.2	-0.5	0.0	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.3	1.5	-0.1	-2.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.2	0.5	-0.2	-1.1	-0.7
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	9.6	-0.2	0.3	0.4	-3.1
Medication: Aspirin	1.1	1.4	3.3	-1.5	-1.8	-0.1	0.2
Supplements: Vitamin C	2.8	3.3	7.8	2.8	1.7	-1.1	1.0
Knee pain experienced in last month	2.1	3.3	5.2	2.3	2.0	-0.2	-2.0
Hypertension (Self-reported)	0.3	0.9	2.1	0.8	-0.9	-0.1	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.2	0.5	-0.1	0.0
Illnesses of father: Heart disease	2.1	3.0	6.5	-2.6	-0.1	1.8	-1.5
Illnesses of siblings: Diabetes	1.0	1.2	2.3	1.3	-0.9	0.3	-1.5
Smoking status: Previous	1.0	1.5	2.9	-1.2	-1.7	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	7.6	-0.8	0.3	2.8	-0.5
Whole body fat-free mass	0.7	4.2	8.5	2.5	2.9	1.4	-0.4
Leg fat-free mass (right)	0.6	3.0	6.7	1.8	2.6	1.5	0.1
Arm fat percentage (left)	0.1	0.5	1.1	-0.3	1.0	-0.9	-0.4
Average weekly red wine intake	0.8	1.2	1.9	0.1	1.0	1.4	-1.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.1	2.0	0.4	-0.1	0.6
Mood swings	2.6	4.8	9.7	-3.1	-2.9	0.7	0.4
Loneliness, isolation	1.5	2.1	4.5	-2.1	-1.3	1.4	-0.6
Long-standing illness, disability or infirmity	1.1	1.6	5.1	0.2	-0.4	1.1	2.3
Ever had bowel cancer screening	0.9	1.0	3.0	-0.9	-0.3	0.3	-1.7
Diabetes diagnosed by doctor	0.7	1.2	4.3	0.3	-0.2	2.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.3	0.6	-0.3	0.9	1.5
Friendships satisfaction	0.8	1.0	3.4	1.9	0.2	0.3	-0.5
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.5	-0.1	0.5	0.5
Commuting to job workplace: Walk	0.3	0.4	0.7	-0.7	-0.5	-0.8	0.1
Eye problems/disorders: Cataract	2.0	2.3	5.1	2.2	1.9	0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.5	-1.2	-1.6	0.5	1.5
Medication for cholesterol	0.8	1.2	3.7	-1.9	-0.3	-0.8	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	0.7	-1.0	-0.9	0.2
Back pain experienced in last month	0.3	0.4	1.0	-0.2	0.6	-1.0	0.4
Mineral and other dietary supplements	0.9	1.2	3.8	-1.9	-0.9	-0.6	0.0
Breast cancer (self-reported)	1.0	1.2	2.3	1.5	0.5	-0.5	1.4
Asthma (self-reported)	1.8	3.6	9.7	-0.9	0.0	-3.1	-2.0
Osteoporosis (self-reported)	0.3	0.4	0.7	0.6	0.5	0.5	0.9
Osteoarthritis (self-reported)	1.9	2.5	3.6	1.4	1.9	-1.0	-1.9
Medication: Aspirin	1.6	2.1	4.3	-1.7	-2.1	0.3	1.1
Medication: Gliclazide	0.6	0.6	1.9	0.7	0.3	0.1	1.4
Illnesses of father: None of the above (group 1)	0.9	1.2	2.9	1.7	-0.1	-0.9	1.0
Smoking status: Current	1.5	2.4	6.9	0.1	-0.8	1.4	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.8	0.3	0.4	1.9	1.1
Whole body water mass	0.8	4.3	9.0	2.5	3.0	1.4	-0.5
Leg predicted mass (right)	0.6	3.1	7.1	1.8	2.7	1.4	0.1
Arm fat mass (left)	0.2	0.9	2.8	0.4	1.7	-0.6	-0.5
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	1.1	0.5	1.0	-0.4
Average weekly champagne plus white wine intake	1.3	1.7	4.4	-0.6	-0.4	1.4	2.1
Miserableness	1.9	3.3	6.2	-2.0	-2.5	0.4	1.6
Guilty feelings	0.4	0.7	2.3	-1.5	-0.2	-0.6	-0.1
Wears glasses or contact lenses	0.7	0.8	2.9	-0.3	0.5	-0.1	-1.7
Ever taken oral contraceptive pill	0.3	0.4	1.1	0.4	0.2	1.1	0.4
Hearing aid user	0.6	0.7	1.5	0.7	-0.8	-0.3	1.2
Mother’s age at death	0.1	0.1	0.3	0.1	0.2	-0.4	0.6
Financial situation satisfaction	1.4	1.8	4.8	-0.2	-2.2	-0.3	1.5
Tinnitus: Yes, now most or all of the time	1.5	1.7	4.9	-0.6	-0.8	-1.0	2.2
Commuting to job workplace: Public transport	0.4	0.5	1.7	0.3	1.3	0.0	-0.4
Eye problems/disorders: Glaucoma	0.4	0.4	1.1	0.4	0.5	1.1	0.5
Medication: Blood pressure	0.5	1.0	3.2	1.8	0.1	-0.3	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	0.4	-0.9	-0.2	-0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.9	2.0	0.3	1.2	0.1
High cholesterol (Self-reported)	1.6	2.9	4.6	2.2	1.9	1.0	-1.5
Medication: Bendroflumethiazide	0.7	1.0	1.4	0.9	-1.2	0.7	1.2
Medication: Paracetamol	0.1	0.2	0.3	0.5	0.5	0.5	0.4
Medication: Lisinopril	0.6	0.8	2.2	1.5	0.6	0.6	0.5
Medication: Atorvastatin	2.7	3.3	12.5	0.1	0.5	3.5	0.7
Illnesses of father: High blood pressure	1.1	1.3	5.2	-0.3	-0.1	-0.2	2.3
Alcohol drinker status: Never	0.8	1.0	2.7	1.6	0.9	0.2	-0.5
Ever smoked	0.2	0.4	0.8	-0.2	-0.9	-0.1	0.9
Basal metabolic rate	0.7	3.6	8.3	2.3	2.9	0.9	-0.4
Leg fat percentage (left)	0.3	0.9	3.3	-0.2	0.1	-1.8	-0.6
Arm fat-free mass (left)	0.7	3.5	7.7	2.5	2.8	0.5	-0.4
Number of operations (self-reported)	1.3	1.9	4.5	2.1	1.5	-0.5	0.9
Average weekly beer plus cider intake	0.2	0.3	0.7	0.7	-0.9	0.3	0.0
Irritability	1.1	1.8	3.6	-1.9	-1.1	-0.4	1.5
Risk taking	0.9	1.3	3.4	-1.8	-0.8	-0.1	-1.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.6	-0.1	-1.3	0.1	-1.0
Fractured/broken bones in last 5 years	0.0	0.0	0.1	-0.0	-0.0	0.3	0.3
Age started oral contraceptive pill	0.9	1.2	1.7	1.0	1.1	-1.3	-0.8
Diastolic blood pressure, automated reading	0.3	1.0	2.1	1.3	1.4	0.7	-0.0
Ever depressed for a whole week	1.2	1.4	2.7	-1.2	-1.6	-0.3	1.2
Unable to work because of sickness or disability	0.4	0.5	0.8	-0.8	-0.9	-0.6	-0.4
Commuting to job workplace: Cycle	1.6	1.9	7.0	0.6	-0.2	-2.6	-0.5
Myopia	0.9	1.3	2.2	-1.4	-1.5	1.1	0.0
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.7	-0.8	0.7	-0.4	-0.8
Cholesterol lowering medication	0.7	1.1	1.6	1.3	0.7	1.2	0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.8	-0.1	0.9	1.3	-0.2
Pain experienced in last month	0.5	0.8	2.1	-0.8	-0.6	0.5	1.5
Supplements: Calcium	1.1	1.2	2.7	1.1	0.4	1.6	0.9
Basal cell carcinoma (self-reported)	1.2	1.4	2.5	1.6	1.1	-1.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.3	-0.5	-0.3	1.8	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.5	0.0	-0.8	-0.4
Heart disease (siblings)	0.4	0.5	1.3	-0.4	-0.6	-0.1	-1.2
Alcohol drinker status: Previous	1.4	1.6	5.5	-0.3	0.2	0.9	-2.3
Pack years of smoking	1.1	1.6	3.2	1.5	0.8	0.4	1.8
Impedance of whole body	0.5	2.4	4.2	-2.0	-1.9	-1.4	0.0
Leg fat mass (left)	0.2	0.8	1.5	0.7	1.2	-1.0	-0.4
Arm predicted mass (left)	0.8	4.1	8.6	2.7	2.9	0.6	-0.5