Hub : Genes

CXCL3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.106	0.039	0.0012	0.009	NA	-0.003	NA	0.006	0.09	NA	0.59	NA	0.14
2	TCGA	Esophageal Carcinoma	0.117	0.062	0.0046	-0.005	0.018	0.002	NA	-0.002	0.50	0.086	0.26	NA	0.38

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.5	-0.2
Bipolar Disorder or Schizophrenia	0.7	1.7	2.2	-1.5	1.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.2	-0.6
Depression (Nagel 2018)	0.1	0.1	0.3	-0.5	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	0.5	0.6
Neuroticism (Nagel 2018)	0.3	0.6	0.7	0.8	-0.8
Schizophrenia (2018)	1.1	2.3	2.5	-1.4	1.6
Schizophrenia vs Biploar Disorder	0.6	0.8	1.3	0.5	-1.1
Worry (Nagel 2018)	0.5	1.0	1.2	1.1	-0.9
Alzheimer’s Disease (in mother)	1.4	1.6	3.1	-0.4	1.8
Alzheimer’s Disease (in father)	0.1	0.2	0.2	0.5	-0.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	-0.1	0.7
Crohns Disease (2017)	0.6	1.3	2.4	-1.6	0.4
Irritable Bowel Disease (IBD)	1.6	3.9	6.5	-1.1	2.6
Ulcerative Colitis (UC)	3.4	6.4	12.8	-0.3	3.6
Major Depression (MDD)	1.5	1.8	3.1	-0.7	-1.8
Reaction Time	0.7	1.4	2.4	0.5	-1.6
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.0	-0.2	-0.1
Breast Cancer	0.2	0.5	0.9	0.9	-0.1
Ovarian Cancer	2.1	2.7	2.8	-1.7	-1.6
Prostate Cancer	0.4	0.6	1.2	-1.1	0.0
Age at First Birth	0.2	0.3	0.5	0.7	0.3
Bipolar Disorder (2011)	2.8	2.7	5.4	-2.3	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	-0.4	-0.6
Coronary Artery Disease (CAD)	0.2	0.3	0.5	0.1	0.7
Crohns Disease (2012)	0.4	0.6	1.1	-1.1	0.1
Mean Putamen Volume	3.9	4.4	5.6	-2.4	1.8
Fasting Glucose	4.3	5.2	10.0	-0.6	-3.2
HbA1C	0.0	0.0	0.1	0.2	-0.2
HDL Cholesterol	0.3	0.5	0.9	0.9	0.4
LDL Cholesterol	0.6	1.0	1.1	1.0	0.9
Lupus	3.0	4.6	4.7	2.1	-2.2
Neuroticism (2016)	0.1	0.1	0.2	0.3	-0.5
Primary Biliary Cirrhosis	1.4	1.9	2.5	1.6	1.2
Rheumatoid Arthritis	0.0	0.0	0.1	0.3	-0.0
Schizophrenia (2014)	0.8	1.7	2.1	-1.5	1.2
Triglycerides	0.7	1.2	1.7	-1.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	-1.1	-0.2
Ulcerative Colitis	2.1	3.0	5.3	-0.9	2.3
Blood Eosinophil Count	0.0	0.3	0.3	0.6	0.5
Blood Platelet Count	0.1	0.9	1.3	-1.1	0.7
Blood Red Count	0.0	0.3	0.5	0.4	0.7
Blood White Count	6.4	47.4	69.6	-5.0	8.3
Heel T-Score	0.0	0.0	0.0	0.2	-0.1
BMI	0.4	2.4	3.7	1.9	-1.0
Height	0.1	1.2	1.7	0.9	-1.3
Waist Hip Ratio (WHR)	0.5	2.1	3.7	-0.7	1.9
Systolic Blood Pressure	0.1	0.3	0.5	-0.7	-0.3
Smoking Status	0.3	0.8	1.5	1.2	-0.0
Allergy or Eczema	0.1	0.2	0.3	-0.4	0.5
Cardiovascular Disease	1.6	5.4	7.6	2.8	-1.8
Hypothyroidism (self reported)	0.8	1.9	3.8	2.0	-0.0
Respiratory disease	0.3	0.6	0.6	-0.8	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.9	-0.1	-1.0
Lung FEV1/FVC ratio	0.1	0.6	1.2	1.1	-0.0
Lung FVC	0.1	0.3	0.3	0.6	0.4
Neuroticism	0.1	0.2	0.3	0.5	-0.4
Chronotype (morning person)	0.1	0.2	0.2	0.3	-0.5
Hair Pigment	0.4	10.4	20.2	4.5	-0.7
Tanning	0.1	0.7	0.9	-0.9	0.8
Hand grip strength (left)	0.3	0.7	1.2	0.5	-1.1
Number of treatments/medications taken	0.7	1.2	1.9	1.4	-0.7
Average weekly spirits intake	1.6	1.9	3.1	-0.9	-1.8
Sensitivity / hurt feelings	0.7	1.2	1.6	1.3	-0.9
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	-0.3	-0.2
Hearing difficulty/problems: Yes	1.2	1.8	2.6	-1.6	1.0
Relative age of first facial hair	1.0	2.0	3.7	1.9	0.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.2	-1.5	-0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	0.0	0.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.1	0.5
Systolic blood pressure, automated reading	0.1	0.2	0.4	0.1	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	0.9	-0.0
Angina	0.0	0.0	0.1	0.1	0.2
Medication for hormone replacement therapy	0.9	1.0	1.1	1.1	-0.9
Vitamin and mineral supplements	0.9	1.3	2.5	-0.2	1.6
Supplements: Zinc	0.8	0.8	1.6	-0.3	-1.3
Medication: Co-codamol	0.0	0.0	0.0	-0.0	-0.2
Medication: Metformin	0.6	0.8	1.5	1.2	-0.4
Diabetes (father)	1.4	1.7	2.4	1.6	1.0
Diabetes (mother)	0.1	0.1	0.1	0.3	0.3
Severe depression (siblings)	0.7	0.8	0.9	-0.9	-0.9
Pack years adult smoking proportion	0.1	0.1	0.2	0.3	-0.4
Impedance of leg (right)	0.1	0.4	0.7	-0.9	0.3
Leg fat-free mass (left)	0.2	1.3	1.6	1.0	-1.3
Trunk fat percentage	0.6	2.3	2.5	1.5	-1.6
Hand grip strength (right)	0.3	0.7	1.4	1.2	-0.2
Townsend deprivation index at recruitment	1.2	1.7	3.3	-0.0	1.8
Current tobacco smoking	0.2	0.4	0.6	-0.4	-0.8
Average weekly fortified wine intake	0.5	0.5	1.0	0.2	1.0
Maternal smoking around birth	0.5	0.7	1.4	-1.2	0.2
Fed-up feelings	0.3	0.6	0.6	-0.8	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.8	-0.9	-0.4
Relative age voice broke	0.1	0.1	0.2	0.3	0.4
Taking other prescription medications	0.0	0.0	0.0	0.1	-0.2
Age when periods started (menarche)	0.4	1.1	1.4	-1.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	0.8	0.9	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	4.6	-2.1	-0.9
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	0.2	0.0
Qualifications: CSEs or equivalent	0.9	1.2	1.8	1.3	-0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.0	-1.0	0.2
High blood pressure	1.0	2.7	5.2	2.3	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	0.1	0.5
Multivitamins +/- minerals	0.1	0.1	0.2	-0.5	-0.2
Stomach or abdominal pain in last month	0.3	0.4	0.6	0.4	-0.7
Supplements: Glucosamine	0.3	0.4	0.5	0.7	0.5
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.0	-1.0	0.9
Medication: Atenolol	0.2	0.3	0.6	0.8	0.0
Medication: Levothyroxine sodium	0.9	1.5	2.1	1.0	-1.4
Sitting height	0.0	0.3	0.5	-0.7	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.4	0.3
High blood pressure (mother)	1.8	2.5	2.8	-1.7	-1.5
Body mass index (BMI)	0.4	1.7	2.0	1.4	-1.2
Impedance of leg (left)	0.1	0.5	0.5	-0.7	0.7
Leg predicted mass (left)	0.3	1.3	1.6	1.0	-1.3
Trunk fat mass	0.6	2.7	3.3	1.5	-1.8
Waist circumference	0.2	0.8	1.2	1.1	-0.7
Number of incorrect matches in round	1.1	1.8	3.6	-0.1	-1.9
Past tobacco smoking	0.2	0.3	0.7	-0.8	-0.0
Alcohol usually taken with meals	0.8	1.3	1.8	1.4	-0.9
Nervous feelings	0.2	0.4	0.7	0.3	-0.9
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	5.8	1.0	2.4
Hearing difficulty/problems with background noise	1.0	1.6	2.9	-0.6	1.7
Hair/balding pattern: Pattern 2	0.8	1.1	2.1	-0.2	1.4
Had menopause	0.0	0.0	0.0	0.1	0.2
Had other major operations	0.2	0.2	0.3	0.4	-0.5
Forced vital capacity (FVC)	0.1	0.2	0.4	0.2	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	2.7	-1.6	-1.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.3	-0.0
Qualifications: None of the above	0.4	0.8	1.3	0.5	1.2
Financial difficulties in last 2 years	0.9	1.2	2.5	-0.0	-1.6
Mouth/teeth dental problems	0.4	0.6	1.1	-1.1	-0.2
Heart attack	0.9	1.2	1.4	-1.2	0.9
Allergy	0.8	1.9	3.8	-0.0	-1.9
Pain all over the body in last month	0.4	0.4	0.9	-0.9	-0.1
Diabetes (self-reported)	0.0	0.0	0.1	0.2	0.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.0	-0.2	1.0
Medication: Ramipril	0.1	0.2	0.2	0.5	-0.4
Medication: Simvastatin	0.4	0.6	0.9	0.6	-0.9
Fluid intelligence score	0.0	0.1	0.1	-0.4	0.1
Illnesses of siblings	0.6	0.8	1.5	-1.2	-0.3
Neuroticism score	0.2	0.5	0.8	0.9	-0.4
Weight	0.4	1.8	2.3	1.2	-1.5
Impedance of arm (right)	0.3	1.4	2.1	-1.4	0.8
Arm fat percentage (right)	0.4	1.5	1.6	1.2	-1.3
Trunk fat-free mass	0.2	1.2	1.3	1.0	-1.2
Hip circumference	0.6	2.6	3.9	1.1	-2.0
Time employed in main current job	2.5	2.8	4.3	2.1	-1.2
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.0	0.7
Father’s age at death	0.2	0.2	0.4	-0.2	0.6
Worrier / anxious feelings	0.0	0.1	0.1	-0.3	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.3	0.6
Falls in the last year	1.6	2.2	3.2	-1.1	-1.8
Hair/balding pattern: Pattern 3	1.1	1.7	2.7	1.6	-0.8
Number of live births	1.5	2.2	2.9	1.2	1.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.4	-0.2	1.2
Pulse rate	0.9	1.5	1.7	1.2	-1.3
Happiness	0.4	0.5	1.0	-0.1	1.0
Noisy workplace	0.3	0.4	0.8	-0.1	0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.4	-0.2	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.3	0.5	-0.2
Mouth/teeth dental problems: Dentures	0.5	0.8	1.4	1.2	-0.5
Asthma	0.6	1.2	2.2	-0.5	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	3.0	-1.2	-1.7
Medication: Cholesterol lowering	0.2	0.3	0.6	0.3	-0.8
Depression (self-reported)	0.6	0.8	1.5	-0.3	-1.2
Medication: Lansoprazole	0.4	0.5	0.8	0.3	0.9
Prospective memory result	1.5	1.8	3.2	-1.8	0.6
Lung cancer (father)	0.0	0.0	0.0	-0.2	0.2
Illnesses of mother	0.5	0.7	1.3	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	0.6	-0.2
Pulse wave Arterial Stiffness index	0.8	1.0	1.8	0.3	-1.4
Impedance of arm (left)	0.3	1.4	2.5	-0.5	1.6
Arm fat mass (right)	0.5	2.1	2.1	1.4	-1.5
Trunk predicted mass	0.2	1.1	1.2	1.0	-1.1
Standing height	0.0	0.4	0.9	-0.0	-0.9
Length of working week for main job	1.8	2.0	2.5	-1.2	1.6
Exposure to tobacco smoke at home	0.6	0.7	1.3	-0.3	1.1
Breastfed as a baby	0.2	0.2	0.5	0.7	0.1
Tense / ‘highly strung’	1.4	2.4	2.7	1.6	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.4	-0.8	-1.8
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	-1.3	-0.2
Birth weight of first child	1.4	2.5	4.1	2.0	-0.9
Peak expiratory flow (PEF)	0.4	0.8	1.7	-0.0	1.3
Pulse wave reflection index	0.6	0.7	1.1	-1.0	0.6
Ever highly irritable/argumentative for 2 days	2.4	2.9	5.7	-0.1	2.4
Loud music exposure frequency	0.7	0.8	1.2	-0.6	1.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	1.7	1.3	-1.2
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.0	-1.1	1.7
Blood clot in the leg (DVT)	1.6	2.1	3.2	1.0	1.8
Medication: Paracetamol	0.0	0.1	0.1	0.2	-0.3
Headache pain in last month	0.5	0.8	1.5	1.2	0.3
Medication for cholesterol, blood pressure or diabetes	3.6	5.9	8.2	-1.9	2.9
Glaucoma (self-reported)	0.6	0.7	1.3	0.3	-1.1
Gout (self-reported)	0.1	0.2	0.3	-0.2	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.0	1.0	-0.1
Medication: Amlodipine	0.2	0.3	0.6	0.8	-0.2
Medication: Ventolin 100micrograms inhaler	2.3	2.9	4.3	-2.1	1.2
Birth weight	1.0	2.2	4.4	2.1	-0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.0	0.7
High blood pressure (siblings)	1.3	1.8	3.2	1.8	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.4	0.5	0.6	-0.7
Body fat percentage	0.5	2.0	2.2	1.3	-1.5
Leg fat percentage (right)	0.5	1.7	2.6	0.9	-1.6
Arm fat-free mass (right)	0.4	2.0	2.7	1.7	-1.1
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.4	0.0
Comparative body size at age 10	2.0	5.7	7.3	2.0	-2.7
Number of full brothers	1.1	1.4	2.2	-0.7	1.5
Worry too long after embarrassment	0.3	0.6	0.6	0.7	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	1.8	-1.3	-1.0
Wheeze or whistling in the chest in last year	1.0	1.7	2.2	-1.5	1.1
Number of children fathered	0.1	0.1	0.2	0.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	0.4	0.5
Age at first live birth	0.4	0.8	1.5	1.2	-0.2
Pulse wave peak to peak time	0.7	0.9	1.6	-0.4	1.3
Health satisfaction	1.1	1.4	2.5	-1.6	-0.7
Shortness of breath walking on level ground	0.8	1.0	1.8	-1.3	-0.3
Qualifications: College or University degree	0.2	0.6	1.1	-1.0	-0.4
Eye problems/disorders: None of the above	4.7	5.5	6.2	-2.5	2.2
Mouth/teeth dental problems: Loose teeth	4.3	5.2	8.6	2.9	1.3
Emphysema/chronic bronchitis	0.6	0.7	1.4	0.1	1.2
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	0.2	-0.2
Neck or shoulder pain in last month	1.5	2.2	2.6	1.6	-1.3
Medication: Blood pressure	4.1	7.3	8.9	2.4	-3.0
Angina (self-reported)	0.0	0.0	0.1	0.3	-0.1
Migraine (self-reported)	0.8	1.0	1.4	-0.8	-1.2
Medication: Ibuprofen	1.2	1.5	1.8	-1.1	-1.3
Medication: Allopurinol	0.0	0.1	0.1	0.3	-0.2
Medication: Omeprazole	0.8	0.9	1.6	0.5	1.2
Medication: Seretide 50 evohaler	1.6	1.8	3.6	0.0	1.9
Mean time to correctly identify matches	0.5	0.9	1.1	0.8	-1.1
Heart disease (mother)	1.0	1.2	2.4	1.5	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	3.7	-1.9	-1.4
Whole body fat mass	0.6	2.5	3.2	1.3	-1.8
Leg fat mass (right)	0.6	2.3	3.0	1.2	-1.7
Arm predicted mass (right)	0.4	2.0	3.1	1.8	-1.0
Pulse rate, automated reading	0.0	0.1	0.1	-0.1	-0.4
Alcohol intake frequency.	0.2	0.4	0.8	0.9	0.2
Comparative height size at age 10	0.5	2.5	3.3	1.8	-1.3
Number of full sisters	1.7	2.0	3.9	2.0	0.4
Suffer from ‘nerves’	0.5	0.8	1.4	1.2	-0.4
Overall health rating	0.2	0.4	0.4	0.6	-0.6
Chest pain or discomfort	1.0	1.5	2.7	0.5	1.6
Had major operations	0.0	0.0	0.1	0.3	0.0
Age at last live birth	0.4	0.5	0.9	0.9	-0.4
Family relationship satisfaction	0.2	0.2	0.4	0.6	0.2
Leg pain on walking	2.4	3.0	5.3	-2.3	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.3	1.4	-1.2	1.0
Commuting to job workplace: Car/motor vehicle	1.1	1.3	1.3	1.1	-1.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.1	-0.1
Medication: Aspirin	0.9	1.1	1.7	0.8	1.3
Supplements: Vitamin C	0.6	0.7	0.9	0.7	-1.0
Knee pain experienced in last month	1.2	1.9	3.4	1.9	-0.6
Hypertension (Self-reported)	1.0	2.7	5.2	2.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	-0.9	-0.2
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.8	-0.2
Illnesses of siblings: Diabetes	0.4	0.5	0.7	0.5	0.8
Smoking status: Previous	1.1	1.6	3.2	1.8	0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	4.1	-0.1	-2.0
Whole body fat-free mass	0.3	1.5	1.6	1.2	-1.2
Leg fat-free mass (right)	0.2	1.0	1.0	1.0	-1.0
Arm fat percentage (left)	0.4	1.7	2.4	1.6	-1.0
Average weekly red wine intake	0.5	0.7	1.2	-1.1	-0.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.5	-1.0	-1.2
Mood swings	0.5	0.8	1.2	-1.1	0.7
Loneliness, isolation	1.8	2.5	4.7	0.6	-2.2
Long-standing illness, disability or infirmity	0.1	0.2	0.3	0.6	-0.0
Ever had bowel cancer screening	0.0	0.0	0.0	-0.2	-0.1
Diabetes diagnosed by doctor	0.2	0.3	0.5	0.7	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.8	0.3	-1.3
Friendships satisfaction	1.0	1.2	1.8	-1.3	0.8
Qualifications: nursing, teaching	0.9	1.4	2.7	-0.1	-1.7
Commuting to job workplace: Walk	0.9	1.0	1.9	-1.4	-0.2
Eye problems/disorders: Cataract	0.0	0.0	0.0	0.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.1	0.2	0.3
Medication for cholesterol	0.4	0.6	1.0	-0.6	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.0	0.2
Back pain experienced in last month	0.5	0.7	1.1	0.5	-1.0
Mineral and other dietary supplements	0.1	0.1	0.1	0.4	0.3
Breast cancer (self-reported)	0.3	0.3	0.5	0.7	-0.3
Asthma (self-reported)	0.5	1.0	1.8	-0.5	1.3
Osteoporosis (self-reported)	0.6	0.7	1.5	1.2	0.0
Osteoarthritis (self-reported)	0.0	0.0	0.0	0.2	-0.1
Medication: Aspirin	0.7	0.9	1.3	0.7	1.1
Medication: Gliclazide	3.9	4.5	8.9	3.0	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.1	0.1	-0.3	-0.0
Smoking status: Current	0.2	0.3	0.3	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.4	0.4	-0.6
Whole body water mass	0.3	1.8	1.9	1.3	-1.4
Leg predicted mass (right)	0.2	1.0	1.0	1.0	-1.0
Arm fat mass (left)	0.5	2.2	2.8	1.7	-1.3
Number of self-reported non-cancer illnesses	2.1	3.6	4.8	1.5	-2.2
Average weekly champagne plus white wine intake	1.5	2.0	2.9	1.7	-1.1
Miserableness	0.2	0.3	0.6	0.2	-0.8
Guilty feelings	0.2	0.3	0.6	-0.2	-0.8
Wears glasses or contact lenses	0.6	0.7	0.9	1.0	-0.6
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.4	0.3
Hearing aid user	3.6	4.1	6.3	-2.5	1.4
Mother’s age at death	0.7	0.9	1.8	-1.3	-0.2
Financial situation satisfaction	0.4	0.6	0.9	-1.0	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.3	-0.5	-0.3
Commuting to job workplace: Public transport	1.2	1.4	2.7	-1.6	-0.3
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	-0.1	-0.8
Medication: Blood pressure	1.2	2.3	4.5	0.3	2.1
Pain type(s) experienced in last month: Hip pain	1.0	1.3	1.8	-1.3	0.9
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	-0.6	-0.2
High cholesterol (Self-reported)	0.2	0.4	0.8	0.9	-0.2
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.6	-0.1
Medication: Paracetamol	0.4	0.7	1.2	1.1	-0.5
Medication: Lisinopril	0.7	0.9	1.4	-1.2	-0.7
Medication: Atorvastatin	0.1	0.1	0.2	-0.5	-0.1
Illnesses of father: High blood pressure	0.4	0.5	1.0	0.2	1.0
Alcohol drinker status: Never	0.0	0.0	0.1	0.1	-0.3
Ever smoked	0.1	0.2	0.4	-0.1	-0.6
Basal metabolic rate	0.3	1.6	1.8	1.2	-1.3
Leg fat percentage (left)	0.4	1.4	2.1	0.9	-1.5
Arm fat-free mass (left)	0.4	2.0	2.2	1.5	-1.4
Number of operations (self-reported)	0.1	0.2	0.3	0.1	-0.5
Average weekly beer plus cider intake	3.7	5.4	8.6	2.9	1.5
Irritability	0.7	1.1	1.9	0.6	1.4
Risk taking	0.0	0.1	0.1	-0.3	0.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	-0.9	0.3
Fractured/broken bones in last 5 years	0.4	0.5	0.6	-0.6	0.7
Age started oral contraceptive pill	0.4	0.5	0.7	-0.8	0.5
Diastolic blood pressure, automated reading	0.2	0.6	1.1	-0.2	-1.1
Ever depressed for a whole week	0.3	0.4	0.8	-0.9	-0.0
Unable to work because of sickness or disability	0.0	0.0	0.0	0.1	0.1
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.3	-0.2
Myopia	0.4	0.6	0.8	-0.9	-0.6
Vascular/heart problems diagnosed by doctor	0.9	2.4	4.6	-2.1	0.4
Cholesterol lowering medication	0.4	0.5	0.9	0.4	0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.0	0.5	1.0
Pain experienced in last month	0.1	0.1	0.2	-0.5	0.1
Supplements: Calcium	1.9	2.1	3.7	0.7	-1.9
Basal cell carcinoma (self-reported)	1.3	1.6	2.2	1.0	-1.5
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.0	-1.0	0.7
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	4.4	0.6	2.1
Heart disease (siblings)	1.1	1.3	1.9	-1.4	0.9
Alcohol drinker status: Previous	0.6	0.7	1.3	0.2	-1.1
Pack years of smoking	0.1	0.2	0.4	0.6	-0.2
Impedance of whole body	0.2	1.0	1.4	-0.7	1.2
Leg fat mass (left)	0.5	2.0	2.9	1.0	-1.7
Arm predicted mass (left)	0.5	2.4	2.5	1.5	-1.6