TWAS hub - CYP3A5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.6340	0.0922	1.2e-05	-0.006	NA	-0.007	NA	0.004	6.3e-01	NA	7.0e-01	NA	2.2e-01
2	GTEx	Pituitary	0.1500	0.0720	9.7e-03	-0.010	NA	-0.006	NA	0.179	6.8e-01	NA	4.8e-01	NA	3.0e-05
3	METSIM	Adipose	0.1529	0.0383	9.9e-13	0.094	0.061	0.087	0.104	0.098	5.6e-14	1.9e-09	6.7e-13	2.7e-15	1.8e-14
4	TCGA	Breast Invasive Carcinoma	0.0645	0.0305	5.8e-11	0.061	0.056	0.051	NA	0.060	1.4e-12	1.6e-11	1.3e-10	NA	2.2e-12
5	TCGA	Colon Adenocarcinoma	0.1260	0.0520	7.5e-10	0.150	0.164	0.191	NA	0.203	5.5e-09	9.6e-10	3.0e-11	NA	6.1e-12
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0685	0.0310	4.5e-10	0.060	0.083	0.079	NA	0.077	2.7e-07	1.3e-09	3.4e-09	NA	4.8e-09
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0969	0.0508	2.8e-07	0.026	0.044	0.034	NA	0.035	5.4e-04	1.0e-05	8.8e-05	NA	7.3e-05
8	TCGA	Kidney Renal Papillary Cell Carcinoma	0.2430	0.0950	1.3e-07	0.020	0.137	0.137	NA	0.113	2.4e-02	3.1e-08	3.1e-08	NA	5.3e-07
9	TCGA	Brain Lower Grade Glioma	0.0532	0.0322	1.7e-05	0.039	0.045	0.032	NA	0.033	2.5e-05	6.2e-06	1.4e-04	NA	1.1e-04
10	TCGA	Liver Hepatocellular Carcinoma	0.2580	0.1040	2.8e-09	0.191	0.172	0.152	NA	0.190	2.4e-09	1.7e-08	1.2e-07	NA	2.5e-09
11	TCGA	Lung Adenocarcinoma	0.0231	0.0171	7.2e-03	0.026	0.018	0.021	NA	0.023	4.2e-04	3.3e-03	1.3e-03	NA	8.2e-04
12	TCGA	Lung Squamous Cell Carcinoma	0.0453	0.0208	7.6e-09	0.067	0.072	0.075	NA	0.072	4.0e-08	1.4e-08	7.1e-09	NA	1.3e-08
13	TCGA	Pancreatic Adenocarcinoma	0.2250	0.0820	1.4e-09	0.272	0.196	0.229	NA	0.244	7.7e-12	1.2e-08	5.3e-10	NA	1.3e-10
14	TCGA	Prostate Adenocarcinoma	0.0548	0.0327	2.8e-07	0.055	0.058	0.071	NA	0.055	2.0e-06	1.1e-06	6.2e-08	NA	2.0e-06
15	TCGA	Soft Tissue Sarcoma	0.0640	0.0380	1.2e-04	0.033	0.061	0.045	NA	0.040	4.6e-03	1.7e-04	1.1e-03	NA	2.0e-03
16	TCGA	Stomach Adenocarcinoma	0.0950	0.0450	1.7e-08	0.071	0.106	0.083	NA	0.086	7.2e-06	4.1e-08	1.3e-06	NA	8.7e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16
Hayfever/allergic rhinitis (self-reported)	12.3	16.3	22.6	3.8	3.1	0.5	4.2	4.8	4.3	4.4	3.9	3.9	4.6	2.6	4.4	4.2	4.7	4.6	4.4
HbA1C	9.6	10.6	20.0	1.3	3.9	0.3	4.1	4.3	4.1	2.9	4.5	3.3	2.1	1.0	1.8	4.3	3.3	3.8	3.2
Supplements: Fish oil (including cod liver oil)	9.6	12.5	23.1	1.9	3.0	-0.9	3.1	3.2	3.5	3.8	3.5	3.5	3.6	3.7	4.4	2.8	4.5	4.4	4.8
Mineral and other dietary supplements	9.0	12.1	22.4	-1.9	-3.3	1.0	-3.2	-3.2	-3.3	-3.6	-3.7	-3.4	-3.7	-3.8	-4.2	-2.9	-3.9	-4.1	-4.7
Allergy or Eczema	6.2	16.5	23.5	1.9	3.7	-0.3	4.3	4.4	4.5	4.5	3.8	4.4	4.5	2.5	4.8	4.1	4.8	4.5	4.8
Supplements: Glucosamine	5.6	7.3	16.6	2.0	1.4	-0.8	1.6	1.9	2.0	3.0	1.9	2.4	3.0	4.1	3.9	1.5	3.2	3.7	4.0
Vitamin and mineral supplements	5.1	6.9	9.1	-1.7	-2.4	-0.4	-3.0	-3.0	-2.9	-2.7	-2.9	-2.7	-3.0	-1.8	-2.8	-2.8	-3.0	-2.7	-3.0
Pulse rate, automated reading	5.0	16.1	30.1	-1.8	-3.4	0.4	-4.9	-4.7	-4.2	-3.3	-5.2	-3.2	-4.7	-3.2	-4.1	-4.4	-3.7	-4.5	-5.5
Hayfever, allergic rhinitis or eczema	4.6	10.0	14.6	1.9	2.6	-0.2	3.2	3.4	3.4	3.5	3.0	3.4	3.5	2.2	3.8	3.1	3.8	3.6	3.7
Rheumatoid Arthritis	4.0	5.5	9.1	0.9	2.8	0.1	2.9	2.8	2.8	1.9	3.0	1.8	2.3	0.2	2.1	2.8	2.8	2.6	2.6
Fluid intelligence score	4.0	8.2	14.0	-3.6	-2.7	-3.6	-2.3	-2.3	-3.3	-3.0	-3.7	-3.4	-2.4	-2.0	-2.3	-2.2	-2.7	-3.0	-2.6
Depression (self-reported)	4.0	4.8	7.5	1.6	1.5	0.3	2.0	2.6	2.2	2.6	1.7	2.3	2.7	1.8	2.5	2.3	2.7	2.6	2.3
Multivitamins +/- minerals	3.9	5.0	7.0	2.3	1.9	0.1	2.3	2.2	2.2	2.3	2.3	2.4	2.6	2.0	2.6	2.0	2.2	2.2	2.6
Prospective memory result	3.8	4.6	11.7	3.4	0.9	1.6	0.5	0.7	1.9	2.8	1.9	3.1	1.6	2.8	2.7	0.4	2.3	2.3	2.0
Heart disease (siblings)	3.7	4.5	9.7	0.8	-2.9	0.3	-3.1	-2.3	-2.8	-1.4	-3.0	-1.8	-1.7	0.3	-1.4	-2.5	-2.4	-2.0	-2.4
Allergy	3.5	8.0	11.4	-1.5	-2.5	0.0	-3.2	-3.4	-3.2	-3.2	-2.4	-3.0	-3.2	-1.6	-3.3	-3.1	-3.4	-3.1	-3.1
Supplements: Calcium	3.5	3.8	7.8	0.6	2.3	-1.7	2.0	2.1	1.8	1.5	1.7	1.3	2.1	1.1	2.0	2.0	2.5	2.6	2.8
Mother’s age at death	3.3	4.1	9.4	0.7	1.9	-0.7	1.9	1.9	2.3	1.9	1.8	2.0	1.8	1.1	2.5	1.7	2.7	2.7	3.1
Reaction Time	3.1	5.9	9.8	-2.1	-2.3	-0.3	-2.2	-2.6	-2.3	-2.4	-2.7	-2.1	-2.8	-2.0	-2.5	-2.4	-2.6	-3.1	-3.0
Medication: Atorvastatin	3.1	3.8	6.9	1.8	1.9	1.4	1.5	1.6	2.1	2.1	2.6	2.3	2.2	2.0	2.1	1.5	1.2	2.1	2.2
Medication: Seretide 50 evohaler	3.0	3.5	7.5	0.1	2.7	0.6	2.5	2.3	2.4	1.7	2.1	2.1	1.8	-0.2	1.6	2.4	1.7	1.4	1.6
Medication: Aspirin	3.0	4.0	6.5	-1.4	-1.3	-1.4	-2.2	-2.3	-2.1	-1.8	-2.1	-1.4	-2.3	-1.4	-2.0	-2.0	-2.5	-2.6	-2.5
Hair/balding pattern: Pattern 4	2.9	6.9	11.7	-2.6	-3.4	-2.3	-2.4	-2.8	-3.1	-3.1	-2.8	-3.1	-2.5	-0.9	-2.4	-2.9	-2.5	-2.5	-1.9
Eye problems/disorders: Glaucoma	2.9	3.4	6.7	-0.8	-2.5	-0.9	-2.2	-2.4	-2.1	-1.8	-2.2	-1.7	-2.0	-0.6	-1.4	-2.6	-1.5	-1.8	-1.5
Crohns Disease (2017)	2.8	6.2	12.9	-3.3	-0.9	-3.6	-1.2	-1.8	-2.3	-3.1	-2.5	-2.8	-2.5	-3.1	-2.5	-1.4	-2.2	-2.8	-2.2
Smoking Status	2.8	6.6	16.5	-1.7	-2.8	1.9	-2.1	-2.4	-2.1	-2.0	-2.1	-1.6	-3.0	-2.2	-3.2	-2.3	-2.8	-3.6	-4.1
Blood Platelet Count	2.7	31.5	53.9	-5.6	-3.1	-1.3	-4.7	-5.7	-5.2	-5.6	-6.1	-5.0	-7.3	-6.5	-6.8	-4.7	-4.7	-6.9	-7.3
Cardiovascular Disease	2.6	8.5	18.1	-0.0	-3.4	-1.2	-4.3	-3.5	-3.7	-1.9	-4.0	-2.1	-2.5	0.2	-2.5	-3.6	-3.1	-2.9	-3.4
Handedness (chirality/laterality): Left-handed	2.5	3.0	7.0	-1.1	-1.3	1.5	-1.8	-1.8	-1.4	-1.3	-1.5	-1.4	-2.1	-1.9	-2.3	-1.5	-1.6	-1.9	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	6.5	-2.5	-0.7	-0.4	-1.4	-1.4	-1.5	-1.6	-1.6	-1.5	-1.9	-2.1	-2.3	-1.1	-2.0	-2.1	-2.6
Medication: Aspirin	2.4	3.2	6.1	-1.0	-1.3	-0.6	-1.8	-2.0	-1.7	-1.7	-1.6	-1.2	-2.1	-1.4	-1.9	-1.8	-2.3	-2.5	-2.4
Alcohol drinker status: Never	2.4	2.8	6.2	0.0	0.9	-2.2	2.0	1.8	1.5	1.2	1.7	1.2	1.8	1.4	2.0	1.5	1.7	1.9	2.5
Past tobacco smoking	2.3	4.3	10.4	1.2	2.0	-1.5	2.0	2.2	1.6	1.4	2.0	1.0	2.7	1.8	2.4	2.1	1.8	2.9	3.2
Illnesses of siblings	2.3	3.2	7.5	0.4	2.6	1.4	2.5	2.1	2.2	1.2	2.7	1.4	1.8	0.2	1.2	2.2	1.1	1.6	1.9
Glaucoma (self-reported)	2.3	2.7	7.5	0.4	-2.4	-1.4	-2.2	-2.4	-1.9	-1.4	-2.1	-1.3	-1.6	0.3	-0.5	-2.7	-0.8	-1.2	-0.8
Ever smoked	2.3	4.0	10.2	-1.0	-1.9	2.5	-1.6	-2.1	-1.1	-1.1	-1.7	-0.6	-2.6	-2.0	-2.3	-1.8	-1.6	-2.8	-3.2
Ever had prostate specific antigen (PSA) test	2.3	2.7	5.9	1.7	0.8	-0.3	1.4	1.4	1.5	1.6	1.4	1.4	1.8	2.1	2.1	1.1	1.8	2.0	2.4
Shortness of breath walking on level ground	2.2	2.6	6.8	1.9	0.2	2.1	0.2	0.7	1.5	2.5	0.8	2.6	1.3	2.2	1.7	0.4	1.6	1.7	1.1
Ovarian Cancer	2.1	2.8	5.6	-1.1	-1.3	-0.4	-2.3	-2.3	-1.7	-1.4	-2.1	-1.1	-2.3	-0.8	-1.5	-2.4	-1.3	-1.7	-1.7
Chronotype (morning person)	2.1	4.9	10.9	0.7	1.5	-1.5	2.2	2.4	1.8	1.9	1.7	1.4	2.8	2.3	2.7	2.0	2.7	2.9	3.3
Mean time to correctly identify matches	2.1	3.9	7.0	-2.1	-1.3	0.4	-1.8	-2.2	-1.5	-1.7	-1.9	-1.3	-2.6	-2.2	-2.0	-1.9	-2.1	-2.6	-2.6
Pain type(s) experienced in last month: Hip pain	2.1	2.6	5.8	-0.0	-1.6	-1.2	-1.9	-2.4	-1.9	-1.4	-1.9	-1.0	-1.9	0.1	-1.3	-2.4	-1.5	-1.9	-1.5
Schizophrenia vs Biploar Disorder	2.0	2.6	5.1	1.4	1.7	0.6	1.4	1.6	1.4	1.4	1.8	1.1	1.9	1.3	1.7	1.6	1.9	2.3	2.2
Medication: Atenolol	2.0	2.5	4.1	-1.4	-1.5	-0.8	-1.3	-1.5	-1.5	-1.6	-1.8	-1.6	-1.9	-1.7	-1.8	-1.3	-1.3	-1.9	-2.0
Vascular/heart problems diagnosed by doctor	2.0	5.4	11.4	-0.3	2.6	0.4	3.4	3.1	2.7	1.2	3.2	1.2	2.4	-0.3	1.6	3.2	2.1	2.6	2.8
Breastfed as a baby	1.9	2.3	3.8	-1.5	-1.5	-0.2	-1.5	-1.7	-1.5	-1.5	-1.6	-1.2	-1.7	-1.1	-1.7	-1.5	-1.9	-2.0	-1.8
Birth weight of first child	1.9	3.4	6.6	-0.0	-2.3	-1.0	-2.5	-2.6	-2.3	-2.0	-2.4	-2.5	-1.8	-0.0	-1.3	-2.6	-1.1	-0.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	3.9	9.6	-1.6	-1.0	-1.3	-1.6	-1.5	-2.3	-2.5	-2.3	-3.1	-2.0	-2.1	-2.3	-1.3	-1.9	-1.9	-2.0
Lung FEV1/FVC ratio	1.8	9.4	18.7	-0.9	-3.7	-2.1	-4.2	-4.3	-3.8	-2.7	-3.7	-2.9	-3.5	-0.2	-1.9	-4.3	-2.0	-2.5	-2.5
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	4.1	0.7	1.4	0.4	1.5	1.7	1.8	1.8	1.6	1.9	1.7	1.0	2.0	1.5	1.5	1.6	1.7
Medication: Simvastatin	1.8	2.6	6.6	-0.0	-2.3	0.2	-2.6	-2.0	-1.8	-0.6	-2.3	-0.8	-1.5	0.0	-1.2	-2.1	-1.1	-1.7	-2.2
Medication for cholesterol	1.8	2.8	5.6	0.5	1.6	1.1	2.2	2.4	2.0	1.4	1.9	1.1	1.7	0.3	1.2	2.2	1.9	1.9	1.8
Commuting to job workplace: Public transport	1.8	2.1	5.4	1.5	0.6	2.3	1.7	1.7	1.6	1.6	1.5	1.7	1.7	0.8	1.4	1.5	0.9	1.0	0.9
Myopia	1.8	2.6	8.9	3.0	0.5	0.3	0.6	1.5	0.7	1.6	0.4	0.6	2.0	2.2	2.1	0.9	2.0	2.2	1.9
Irritable Bowel Disease (IBD)	1.7	4.1	14.8	-3.3	-0.5	-3.8	-0.8	-1.2	-1.5	-2.1	-2.1	-2.0	-2.1	-2.7	-1.7	-0.9	-1.0	-1.8	-1.3
Age at First Birth	1.7	2.5	5.1	1.6	2.2	-0.2	1.3	1.5	1.1	1.3	0.7	0.8	1.7	1.4	1.7	1.4	2.2	2.1	2.2
Mean Putamen Volume	1.7	1.9	4.2	0.6	-1.4	-1.2	-2.0	-1.9	-1.8	-1.0	-2.0	-1.0	-1.1	0.7	-0.5	-2.0	-1.1	-1.1	-1.0
Fasting Glucose	1.7	2.0	3.4	1.8	1.6	1.4	0.9	1.5	1.5	1.6	1.6	1.4	1.0	1.0	1.2	1.5	1.5	1.7	1.2
Triglycerides	1.7	2.7	4.5	-0.7	-2.1	0.3	-2.0	-1.9	-1.7	-1.4	-1.8	-1.3	-1.7	-0.9	-1.7	-1.9	-1.8	-1.8	-2.0
Type 2 Diabetes (T2D) (2012)	1.7	2.0	5.4	2.1	0.4	-0.4	0.9	1.1	1.0	1.8	1.2	1.5	1.6	2.3	1.8	0.7	1.3	1.4	1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	10.3	-0.1	-2.6	0.5	-2.9	-2.9	-2.2	-1.2	-2.0	-1.2	-2.0	0.9	-0.9	-3.2	-1.7	-1.8	-1.8
High blood pressure	1.7	4.7	10.5	0.2	-2.5	-0.4	-3.2	-2.9	-2.6	-1.1	-3.0	-1.1	-2.1	0.3	-1.4	-3.0	-1.9	-2.3	-2.6
Pulse rate	1.7	2.8	6.5	0.6	-1.7	0.3	-2.4	-1.9	-1.9	-1.0	-2.4	-1.0	-1.4	-0.8	-1.6	-1.8	-1.7	-1.8	-2.5
Exposure to tobacco smoke at home	1.7	1.9	4.4	-0.1	1.2	0.1	2.1	2.0	1.9	0.9	2.1	1.2	1.3	-0.8	0.8	2.0	1.3	1.1	0.9
Pulse wave reflection index	1.7	2.1	3.4	-1.1	-1.5	-0.5	-1.4	-1.8	-1.7	-1.8	-1.0	-1.7	-1.5	-0.3	-1.4	-1.8	-1.7	-1.5	-1.2
Diastolic blood pressure, automated reading	1.7	5.1	10.2	0.5	-2.5	-0.4	-3.2	-3.2	-2.6	-1.5	-3.1	-1.4	-2.4	-0.2	-1.7	-3.2	-1.9	-2.4	-2.6
Primary Biliary Cirrhosis	1.6	2.2	4.4	0.7	0.4	-0.7	1.0	1.4	1.4	1.9	1.1	1.8	1.8	1.9	1.9	1.0	2.1	1.8	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	3.7	0.4	0.9	0.5	1.9	1.7	1.6	1.1	1.9	1.2	1.6	0.4	1.4	1.6	1.3	1.2	1.5
Medication: Blood pressure	1.6	3.0	5.2	-0.5	-2.3	-1.2	-2.1	-2.2	-2.0	-1.2	-2.2	-0.9	-1.7	-0.3	-1.1	-2.2	-1.8	-2.1	-2.0
Verbal and Numeric Reasoning (VNR)	1.5	3.7	5.7	-2.3	-1.6	-1.7	-1.3	-1.5	-1.9	-2.0	-2.4	-2.0	-1.9	-2.1	-1.9	-1.2	-1.8	-2.4	-2.1
Respiratory disease	1.5	3.3	5.0	0.2	1.6	0.0	2.2	2.2	2.2	1.9	1.9	2.2	2.1	0.9	1.9	2.0	2.0	1.9	1.9
Taking other prescription medications	1.5	2.4	4.0	1.3	0.9	-1.0	1.5	1.7	1.5	1.6	1.2	1.7	1.9	1.4	2.0	1.4	1.7	1.5	1.8
Neck or shoulder pain in last month	1.5	2.1	3.7	1.8	1.2	0.2	1.0	1.4	1.2	1.7	1.4	1.4	1.7	1.9	1.9	1.1	1.4	1.6	1.5
Chest pain or discomfort	1.5	2.2	4.2	-0.4	-1.6	0.7	-1.9	-1.7	-1.6	-1.1	-1.6	-1.0	-1.4	-0.3	-1.5	-1.7	-2.1	-1.8	-1.9
Hypertension (Self-reported)	1.5	4.3	9.8	0.3	-2.5	-0.3	-3.1	-2.7	-2.4	-1.0	-2.9	-1.0	-2.0	0.4	-1.2	-2.9	-1.8	-2.1	-2.4
Had menopause	1.4	1.7	3.9	1.2	2.0	-0.0	1.1	1.2	1.5	1.4	1.2	1.4	1.1	0.3	1.6	1.2	1.5	1.4	1.5
Noisy workplace	1.4	1.7	3.6	-1.5	-0.8	-0.1	-1.2	-1.6	-1.0	-1.2	-1.2	-1.0	-1.9	-1.4	-1.4	-1.4	-0.9	-1.5	-1.6
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	6.4	-0.1	0.9	0.2	2.5	2.2	1.8	0.7	2.0	0.5	1.6	-0.2	1.3	2.1	1.4	1.6	2.1
Medication: Amlodipine	1.4	2.0	3.9	-0.7	-1.7	0.3	-1.4	-2.0	-1.1	-1.2	-0.7	-0.5	-1.9	-0.6	-1.5	-1.8	-1.7	-1.9	-1.8
Leg fat percentage (right)	1.4	5.0	12.9	-1.0	-2.7	0.2	-2.4	-2.6	-2.0	-1.4	-2.1	-1.0	-2.6	-1.5	-2.3	-2.3	-2.3	-3.1	-3.6
Medication for pain relief, constipation, heartburn	1.4	2.3	4.0	0.6	1.5	0.7	1.7	1.9	1.6	1.4	1.2	1.0	1.8	0.7	1.6	1.9	1.6	2.0	2.0
Medication: Blood pressure	1.4	2.5	4.8	-0.0	-1.1	-0.2	-2.1	-2.2	-1.6	-1.0	-1.9	-0.7	-1.9	-0.4	-1.7	-2.0	-1.5	-1.9	-2.2
Hearing aid user	1.4	1.6	3.2	1.6	1.6	-0.1	0.5	0.8	0.9	1.1	1.0	1.1	1.4	1.7	1.6	0.6	1.1	1.6	1.8
Medication: Bendroflumethiazide	1.4	2.1	4.4	-1.1	-2.1	-1.0	-1.6	-1.7	-1.6	-1.1	-2.1	-0.9	-1.5	-0.6	-1.3	-1.7	-1.1	-1.5	-1.6
Leg fat percentage (left)	1.4	4.9	13.2	-0.8	-2.7	0.5	-2.5	-2.6	-1.9	-1.4	-2.0	-0.9	-2.6	-1.6	-2.2	-2.4	-2.3	-3.0	-3.6
Fractured/broken bones in last 5 years	1.4	1.8	3.9	0.2	1.7	-0.2	2.0	1.5	1.8	0.5	1.8	0.9	1.2	-0.3	1.2	1.3	1.2	1.5	1.9
Depression (Nagel 2018)	1.3	1.9	4.5	-1.8	-0.3	1.1	-1.0	-1.0	-0.9	-1.1	-1.1	-0.9	-1.5	-2.0	-2.0	-0.6	-1.6	-1.6	-2.1
Intelligence (Savage-Jansen 2018)	1.3	4.1	6.0	-1.9	-2.2	-1.7	-1.7	-1.9	-2.3	-2.2	-2.5	-2.3	-1.9	-1.6	-1.7	-1.7	-2.2	-2.3	-2.0
Crohns Disease (2012)	1.3	2.1	5.4	-1.5	-1.4	-2.3	-0.8	-1.0	-1.6	-1.7	-1.7	-1.9	-1.2	-1.1	-1.4	-0.9	-1.0	-1.4	-1.1
Current tobacco smoking	1.3	2.2	5.6	-1.8	-0.5	0.7	-0.5	-0.9	-0.9	-1.5	-0.3	-1.0	-1.5	-2.0	-2.4	-0.5	-1.9	-2.1	-2.3
Worrier / anxious feelings	1.3	2.4	5.7	-0.0	-1.5	-0.0	-2.3	-2.2	-2.1	-1.3	-1.8	-1.7	-1.2	1.0	-0.6	-2.4	-1.7	-1.0	-0.6
Diabetes diagnosed by doctor	1.3	2.1	5.0	-0.4	-2.0	0.8	-2.2	-1.9	-1.4	-0.6	-1.6	-0.6	-1.5	-0.2	-1.2	-1.9	-1.3	-1.5	-2.0
Smoking status: Current	1.3	2.0	5.0	-1.6	-0.7	0.7	-0.6	-0.9	-1.0	-1.5	-0.3	-1.1	-1.4	-1.7	-2.2	-0.5	-1.9	-2.0	-2.2
Average weekly beer plus cider intake	1.3	1.9	4.1	-0.6	-1.6	0.6	-1.6	-1.8	-1.2	-0.8	-1.3	-0.4	-1.9	-0.8	-1.3	-1.7	-1.3	-1.9	-2.0
Blood Red Count	1.2	11.1	29.8	3.9	-5.1	0.8	-3.3	-4.9	-3.1	-2.1	-1.9	-0.2	-2.4	3.4	0.0	-5.5	-4.5	-3.8	-1.0
Waist circumference	1.2	4.4	13.2	-1.1	-2.5	0.9	-2.0	-2.1	-1.5	-1.2	-2.0	-0.8	-2.6	-2.4	-2.4	-1.9	-1.8	-2.8	-3.6
Chronic bronchitis/emphysema (mother)	1.2	1.3	3.7	0.8	1.5	0.7	1.3	1.3	1.6	1.5	1.0	1.9	0.9	-0.5	0.7	1.5	1.1	0.6	0.2
Pulse wave peak to peak time	1.2	1.4	3.0	-1.0	1.3	-0.4	1.7	1.7	1.4	0.9	0.8	0.6	0.9	-0.4	0.9	1.7	1.7	1.2	1.3
Had major operations	1.2	1.4	3.5	0.5	0.4	-0.5	0.7	0.9	0.9	1.1	1.0	1.1	1.6	1.9	1.7	0.6	0.9	1.6	1.8
Major Depression (MDD)	1.1	1.4	2.2	-1.4	-0.9	-0.9	-1.3	-1.3	-1.4	-0.8	-1.5	-1.0	-1.5	0.0	-1.1	-1.1	-0.6	-1.3	-1.5
Bipolar Disorder (2011)	1.1	1.1	2.7	-1.2	-1.0	-0.4	-0.5	-0.9	-0.7	-1.2	-0.2	-0.8	-1.0	-1.0	-1.3	-0.8	-1.6	-1.4	-1.3
Type 2 Diabetes (T2D) (2018)	1.1	2.0	5.3	0.3	-2.3	1.3	-2.3	-2.0	-1.0	0.1	-1.5	0.3	-1.3	0.5	-0.6	-2.1	-0.8	-1.2	-1.7
Pack years adult smoking proportion	1.1	1.7	4.4	-0.4	-1.2	0.8	-1.6	-1.5	-1.1	-0.7	-1.4	-0.4	-1.6	-0.7	-1.6	-1.3	-1.2	-1.6	-2.1
Body mass index (BMI)	1.1	4.6	14.4	-0.7	-2.4	0.9	-2.0	-2.3	-1.5	-1.2	-1.9	-0.6	-2.8	-2.3	-2.3	-2.0	-1.9	-3.1	-3.8
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	6.8	-0.6	-2.6	0.1	-2.3	-2.2	-1.8	-0.8	-1.8	-0.8	-1.5	0.7	-0.6	-2.6	-1.3	-1.6	-1.7
Medication: Cholesterol lowering	1.1	1.7	5.6	0.1	-1.2	0.1	-2.4	-1.6	-1.7	-0.3	-1.9	-0.5	-0.9	0.7	-1.0	-1.7	-1.2	-1.2	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	8.4	1.6	0.5	2.9	0.3	0.5	1.0	1.8	0.8	1.7	0.7	1.0	0.7	0.5	0.9	0.4	-0.2
Heart disease (mother)	1.1	1.4	3.8	-0.2	-1.4	0.0	-2.0	-1.5	-1.5	-0.5	-1.5	-0.8	-1.0	0.6	-0.7	-1.5	-1.2	-1.0	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	6.9	-2.6	-0.3	-2.4	-0.4	-0.8	-0.8	-1.2	-0.7	-1.0	-1.2	-0.9	-0.7	-0.6	-0.6	-0.9	-0.6
Illnesses of siblings: Diabetes	1.1	1.3	3.4	0.8	-0.4	-0.6	0.7	0.6	1.0	1.3	0.8	1.3	0.9	1.6	1.9	0.2	1.8	1.2	1.5
Number of self-reported non-cancer illnesses	1.1	1.9	4.6	1.5	0.2	-0.2	0.6	0.8	1.3	2.1	0.5	2.1	1.1	1.7	2.0	0.4	2.1	1.2	1.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	3.7	-0.6	1.9	0.2	1.8	1.7	1.7	1.0	0.8	1.0	0.5	-1.2	0.5	1.8	1.4	0.8	0.6
BMI	1.0	6.1	19.4	-0.8	-2.3	1.8	-2.3	-2.7	-1.6	-1.2	-1.9	-0.4	-3.2	-2.5	-2.8	-2.2	-2.3	-3.7	-4.4
Systolic Blood Pressure	1.0	4.8	10.5	0.4	-2.6	-2.6	-3.2	-2.7	-2.9	-1.4	-3.1	-1.6	-1.5	1.3	-0.9	-3.0	-1.9	-1.7	-1.6
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.9	-0.8	0.1	-0.4	-1.1	-1.4	-1.0	-1.3	-0.5	-1.3	-1.7	-1.4	-1.4	-1.0	-0.8	-1.2	-1.2
Maternal smoking around birth	1.0	1.5	6.9	1.0	1.6	2.6	0.3	0.5	1.4	1.7	1.3	1.9	0.5	0.3	0.7	0.7	0.9	0.4	-0.1
Stomach or abdominal pain in last month	1.0	1.3	4.0	0.7	1.4	1.1	1.6	1.4	1.4	0.8	2.0	1.3	1.1	-0.2	0.6	1.5	0.2	0.5	0.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.8	-0.8	-1.3	-1.3	-1.1	-1.0	-1.3	-1.2	-1.4	-1.1	-0.9	-0.5	-1.1	-1.1	-1.2	-1.0	-1.1
Illnesses of father: Heart disease	1.0	1.4	4.8	2.0	-0.7	0.7	0.2	0.5	0.6	1.6	0.6	1.4	1.1	2.2	1.6	0.1	1.2	1.2	1.1
Number of operations (self-reported)	1.0	1.5	3.3	0.9	1.1	0.5	1.6	1.1	1.5	1.1	1.8	1.4	1.0	0.6	1.2	1.1	1.4	1.1	1.3
Age started oral contraceptive pill	1.0	1.2	6.6	1.3	-0.7	0.9	-0.4	0.2	0.1	0.9	0.5	0.3	1.1	2.6	1.6	-0.3	0.5	1.4	1.5
Prostate Cancer	0.9	1.2	2.3	-0.9	-0.1	-1.4	-0.4	-0.9	-1.0	-1.5	-0.8	-1.2	-1.1	-1.3	-1.5	-0.6	-1.2	-1.3	-1.2
Waist Hip Ratio (WHR)	0.9	4.1	6.9	-1.9	-2.3	0.9	-2.2	-2.4	-1.7	-1.8	-1.7	-1.2	-2.4	-1.4	-2.5	-2.3	-2.1	-2.2	-2.6
Average weekly spirits intake	0.9	1.1	4.6	-0.1	0.2	1.3	-0.2	-0.4	-0.1	-0.8	-0.2	-0.4	-1.4	-2.1	-1.5	-0.1	-1.1	-1.5	-1.7
Diabetes (father)	0.9	1.1	2.4	0.4	0.3	-0.8	1.5	1.2	1.2	0.8	1.4	0.9	0.9	0.5	1.1	1.1	1.4	1.1	1.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.5	-0.2	1.6	1.0	1.6	0.8	1.3	0.5	1.9	1.0	0.3	-0.7	0.2	1.1	0.6	0.1	0.3
Hair/balding pattern: Pattern 2	0.9	1.2	3.3	1.6	1.1	0.5	0.4	0.6	0.8	1.1	1.0	1.2	1.1	1.8	1.2	0.4	0.6	1.3	1.3
Happiness	0.9	1.1	4.5	0.1	0.8	2.1	1.0	1.0	1.5	1.0	1.5	1.4	0.7	-0.5	0.5	0.9	0.4	0.6	0.4
Pulse wave Arterial Stiffness index	0.9	1.1	2.3	1.0	-1.1	0.4	-1.4	-1.4	-1.2	-0.7	-0.6	-0.5	-0.7	0.5	-0.8	-1.4	-1.5	-0.9	-1.1
Gout (self-reported)	0.9	1.3	2.9	-1.4	-1.1	-0.1	-0.7	-1.0	-0.9	-0.9	-1.3	-0.8	-1.4	-1.2	-1.3	-1.0	-0.6	-1.5	-1.7
Worry too long after embarrassment	0.9	1.5	3.1	-0.3	-1.2	-0.6	-1.3	-1.4	-1.8	-1.3	-1.3	-1.6	-0.7	0.5	-1.0	-1.4	-1.6	-1.2	-0.9
Smoking status: Previous	0.9	1.4	3.2	-0.1	-1.1	0.8	-1.4	-1.5	-1.0	-0.6	-1.4	-0.3	-1.6	-0.5	-1.2	-1.5	-0.9	-1.6	-1.8
Qualifications: nursing, teaching	0.9	1.3	3.8	-0.1	1.5	0.7	1.6	1.8	1.4	0.9	1.4	0.7	1.1	-0.4	0.5	1.9	0.7	1.1	0.9
Guilty feelings	0.9	1.4	2.9	1.5	-1.2	1.5	-1.4	-1.6	-1.2	-0.8	-0.8	-0.7	-0.7	0.8	-0.7	-1.7	-1.6	-1.1	-1.0
Financial situation satisfaction	0.9	1.1	4.9	-1.5	1.2	1.1	1.1	0.9	1.2	0.0	1.3	0.4	-0.2	-2.2	-0.7	1.2	0.1	-0.2	-0.5
Bipolar Disorder (2018)	0.8	1.3	4.3	-1.3	-0.1	-0.8	-0.3	-0.6	-0.6	-1.0	-1.0	-0.5	-1.0	-2.1	-1.4	-0.4	-1.3	-1.8	-1.8
HDL Cholesterol	0.8	1.3	3.3	-0.0	1.7	-0.7	1.8	1.4	1.1	0.3	1.7	0.4	1.1	0.0	0.7	1.5	0.7	1.0	1.4
Lupus	0.8	1.2	4.1	1.0	-2.0	-0.9	-1.4	-1.3	-1.4	-0.7	-1.1	-0.9	-0.6	1.1	0.1	-1.7	-0.5	-0.5	-0.3
Systolic blood pressure, automated reading	0.8	2.4	6.9	1.7	-2.0	-0.5	-2.6	-2.2	-1.7	0.1	-1.8	-0.0	-0.8	2.3	0.2	-2.5	-0.8	-0.6	-0.8
Sitting height	0.8	5.6	12.2	2.4	1.3	-0.0	3.3	3.5	2.0	1.3	1.9	0.4	3.2	1.0	2.0	3.2	2.3	2.8	3.1
Number of incorrect matches in round	0.8	1.3	9.2	-1.6	-0.3	-3.0	-0.3	-0.4	-1.0	-1.1	-1.0	-1.2	-0.8	-1.1	-1.0	-0.1	-0.3	-0.7	-0.7
Medication: Ramipril	0.8	1.0	4.5	-1.2	0.4	-2.1	-0.5	-0.6	-0.8	-1.0	-1.2	-0.8	-0.9	-1.1	-1.0	-0.3	-1.0	-0.9	-0.8
Medication: Lansoprazole	0.8	0.9	7.2	0.2	0.9	-2.7	0.3	0.5	0.3	0.8	-0.5	0.6	0.5	0.5	1.1	0.4	1.1	0.6	0.8
Mouth/teeth dental problems: Loose teeth	0.8	1.0	4.0	-1.7	0.5	0.3	1.1	0.7	0.4	-0.6	0.8	-0.0	0.1	-2.0	-1.0	1.2	-1.1	-1.0	-0.8
Leg fat mass (right)	0.8	3.3	11.2	-0.8	-2.1	0.7	-1.6	-1.7	-1.3	-0.9	-1.7	-0.6	-2.1	-2.0	-2.1	-1.5	-1.6	-2.6	-3.3
Alcohol intake frequency.	0.8	1.9	4.8	-0.2	1.3	-2.2	1.6	1.4	1.3	1.1	1.3	1.4	1.1	0.8	1.2	1.4	1.7	1.4	1.8
Number of full sisters	0.8	0.9	2.2	0.2	-1.0	0.5	-1.1	-1.1	-1.0	-0.7	-0.7	-0.4	-1.2	-0.2	-0.9	-1.1	-1.1	-1.4	-1.5
Age at last live birth	0.8	1.2	8.6	-1.7	-0.5	-2.9	0.3	0.1	-0.7	-1.2	-0.9	-1.3	-0.3	-1.2	-0.8	0.3	-0.8	-0.7	-0.3
Breast cancer (self-reported)	0.8	1.0	1.9	1.0	1.4	-0.1	1.3	1.1	1.2	0.9	0.8	1.2	0.9	-0.2	0.8	1.2	1.2	0.7	0.8
Commuting to job workplace: Cycle	0.8	1.0	1.6	-0.5	-0.3	0.6	-1.2	-1.2	-1.0	-0.9	-1.3	-1.0	-1.1	-0.9	-1.1	-1.0	-0.9	-0.9	-1.1
Pack years of smoking	0.8	1.1	3.7	-0.1	-0.7	1.4	-1.3	-1.2	-0.7	-0.2	-1.0	-0.0	-1.3	-0.7	-1.4	-0.9	-1.0	-1.3	-1.9
Leg fat mass (left)	0.8	3.3	11.5	-0.6	-2.0	0.8	-1.7	-1.7	-1.3	-0.9	-1.7	-0.5	-2.1	-2.1	-2.1	-1.5	-1.6	-2.6	-3.4
Breast Cancer	0.7	1.7	5.6	-0.7	-2.4	-1.4	-1.6	-1.3	-1.6	-1.2	-1.7	-1.5	-0.8	0.2	-0.5	-1.6	-1.3	-0.9	-0.5
Blood Eosinophil Count	0.7	5.1	9.4	-0.1	2.6	-0.5	2.8	2.6	3.0	2.5	2.3	3.1	2.0	0.1	2.4	2.6	2.5	1.7	2.0
Number of treatments/medications taken	0.7	1.2	3.9	1.1	-1.1	-1.6	-1.4	-1.2	-1.3	0.0	-1.3	0.1	-0.0	2.0	0.4	-1.5	-0.5	-0.5	-0.3
Relative age of first facial hair	0.7	1.5	3.9	1.8	0.8	-0.3	0.6	1.2	0.5	1.3	0.6	0.7	1.8	2.0	1.6	1.0	1.1	1.3	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.4	-1.2	-0.2	0.4	-0.5	-0.8	-0.4	-0.8	-0.4	-0.4	-1.3	-1.5	-1.4	-0.5	-0.8	-1.3	-1.4
Loud music exposure frequency	0.7	0.7	3.5	1.1	-1.3	1.9	-0.7	-0.8	-0.4	-0.4	-0.3	-0.2	-0.6	-0.2	-0.4	-1.0	-0.5	-0.9	-1.0
Blood clot in the leg (DVT)	0.7	0.9	2.7	-0.4	1.6	0.2	1.3	1.3	1.3	0.8	0.4	0.7	0.2	-1.2	0.2	1.4	1.1	0.5	0.2
High blood pressure (siblings)	0.7	1.0	2.9	0.3	-1.5	-0.8	-1.7	-1.4	-1.1	-0.3	-1.6	-0.5	-0.9	0.6	-0.2	-1.5	0.0	-0.4	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.0	0.6	-1.5	1.7	-1.2	-1.0	-0.7	-0.0	-0.9	-0.2	-0.6	0.5	-0.3	-1.2	-0.3	-0.5	-0.8
Arm fat percentage (left)	0.7	2.8	9.5	-0.7	-1.9	0.2	-1.7	-1.7	-1.4	-0.8	-1.8	-0.5	-1.9	-1.6	-1.7	-1.5	-1.5	-2.5	-3.1
Arm fat mass (left)	0.7	3.0	10.5	-0.5	-2.0	0.8	-1.4	-1.5	-1.2	-0.9	-1.6	-0.6	-2.0	-2.1	-2.0	-1.3	-1.4	-2.5	-3.2
Medication: Lisinopril	0.7	1.0	2.0	1.1	-1.1	1.0	-1.4	-1.2	-1.0	-0.3	-1.0	-0.3	-0.6	0.4	-0.5	-1.2	-1.1	-1.1	-1.3
Ever depressed for a whole week	0.7	0.8	3.1	0.7	0.3	1.8	0.9	1.2	1.0	0.8	1.1	0.7	1.0	0.1	0.4	1.1	0.5	0.9	0.5
Alzheimer’s Disease (in father)	0.6	0.7	1.7	-0.2	-0.7	-0.4	-0.5	-0.4	-0.9	-1.0	-0.7	-1.3	-0.7	-0.9	-1.3	-0.2	-1.0	-0.7	-0.9
Coronary Artery Disease (CAD)	0.6	0.7	2.1	1.1	-0.5	-1.4	-1.3	-0.6	-1.0	0.3	-1.0	-0.3	0.2	1.5	0.2	-0.8	-0.4	-0.0	-0.3
Height	0.6	10.8	21.3	3.8	2.5	2.0	3.6	4.3	2.8	2.4	2.7	0.8	4.3	1.7	2.6	4.1	3.5	4.6	4.2
Medication: Co-codamol	0.6	0.7	2.8	0.9	1.3	1.7	0.8	0.5	1.0	0.6	1.4	1.0	0.3	-0.2	0.0	0.9	-0.1	0.2	0.2
Financial difficulties in last 2 years	0.6	0.8	2.7	-0.3	0.3	1.4	0.2	-0.3	-0.2	-1.0	0.5	-0.4	-0.6	-1.3	-1.4	-0.1	-1.6	-1.2	-1.1
Heart attack	0.6	0.8	1.3	-0.3	-0.4	0.1	-0.9	-0.8	-1.0	-0.9	-1.0	-1.1	-1.0	-0.4	-1.1	-0.8	-1.1	-1.0	-1.0
Diabetes (self-reported)	0.6	0.9	3.6	-0.0	-1.2	1.9	-1.3	-1.1	-0.4	0.1	-0.4	0.4	-0.9	-0.1	-0.6	-1.1	-0.6	-0.9	-1.5
Arm fat percentage (right)	0.6	2.5	8.7	-0.7	-1.7	-0.0	-1.6	-1.6	-1.2	-0.7	-1.6	-0.3	-1.9	-1.6	-1.6	-1.4	-1.4	-2.4	-3.0
Lung cancer (father)	0.6	0.7	1.7	0.5	0.9	-0.5	0.4	0.3	0.9	1.0	0.8	1.2	0.8	0.6	1.0	0.4	1.3	1.1	1.0
Arm fat mass (right)	0.6	2.6	9.8	-0.4	-1.8	0.9	-1.3	-1.4	-0.9	-0.7	-1.4	-0.4	-1.9	-2.2	-1.9	-1.1	-1.2	-2.3	-3.1
Standing height	0.6	6.1	12.0	2.7	1.4	1.3	2.7	3.3	2.3	2.0	1.6	0.9	3.2	1.3	2.2	3.0	2.9	3.5	3.1
Length of working week for main job	0.6	0.6	3.0	-0.8	0.3	0.6	0.1	-0.3	-0.2	-1.1	-0.0	-0.8	-1.0	-1.7	-1.2	-0.0	-1.0	-0.7	-0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.5	0.2	1.4	-0.9	0.9	1.3	0.9	1.0	0.9	0.7	1.1	0.7	1.4	1.2	1.4	1.5	1.6
Body fat percentage	0.6	2.3	7.0	-0.1	-2.1	-0.0	-1.9	-1.7	-1.3	-0.5	-1.9	-0.2	-1.6	-0.8	-1.2	-1.7	-1.2	-2.0	-2.6
Exposure to tobacco smoke outside home	0.6	0.8	5.1	-0.7	0.6	0.8	0.7	0.2	0.3	-0.5	0.3	-0.3	-0.8	-2.2	-1.3	0.7	-0.2	-0.9	-1.2
Angina (self-reported)	0.6	0.8	2.6	0.3	-0.9	-0.3	-1.5	-1.5	-0.9	-0.3	-1.0	-0.0	-1.0	0.6	-0.4	-1.6	-0.9	-0.8	-0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.5	0.4	-0.8	-1.9	-1.1	-0.6	-0.7	0.2	-1.8	-0.4	-0.3	0.9	0.3	-0.8	0.9	0.5	0.3
Supplements: Vitamin C	0.6	0.7	1.8	0.3	-0.8	-0.8	0.7	0.7	0.4	0.7	0.4	0.4	1.1	1.3	1.0	0.5	1.0	1.0	1.2
Ever had bowel cancer screening	0.6	0.7	6.2	-0.9	0.7	-2.5	0.0	0.0	-0.7	-0.8	-0.6	-1.0	-0.3	-0.7	-0.5	0.2	-0.4	-0.5	-0.3
Miserableness	0.6	1.0	2.6	-0.0	-0.6	1.6	-1.1	-1.3	-1.0	-0.7	-1.0	-0.8	-1.1	-0.3	-1.1	-1.1	-1.0	-1.2	-1.2
Medication: Paracetamol	0.6	0.9	1.9	-0.1	-1.2	0.6	-0.9	-1.2	-0.9	-0.7	-1.0	-0.5	-1.0	-0.5	-1.1	-1.1	-0.7	-1.3	-1.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.4	-0.4	-0.4	-0.2	-1.0	-0.9	-1.1	-1.0	-1.1	-1.2	-1.0	-0.3	-1.1	-0.9	-1.1	-0.9	-1.0
Alcohol drinker status: Previous	0.6	0.7	1.9	0.1	-1.4	-1.1	-0.8	-0.7	-1.1	-0.7	-1.2	-0.7	-0.4	0.0	-0.8	-0.7	-0.6	-0.7	-0.9
Body Mass Index (BMI) (2010)	0.5	0.7	2.1	-0.6	-0.1	1.0	-0.1	-0.1	-0.3	-0.8	-0.2	-0.5	-0.7	-1.2	-1.1	-0.1	-1.4	-1.2	-1.3
LDL Cholesterol	0.5	0.7	1.6	0.9	1.2	0.3	1.0	1.0	1.1	0.7	1.0	0.9	0.8	-0.3	0.6	1.1	0.7	0.6	0.6
Hypothyroidism (self reported)	0.5	1.2	2.7	1.1	1.0	-0.6	0.2	0.8	0.6	1.2	0.4	0.6	1.1	1.4	1.5	0.6	1.5	1.6	1.6
Hand grip strength (left)	0.5	1.3	2.9	1.4	1.0	-1.7	1.2	1.6	0.3	0.4	0.2	-0.6	1.5	0.4	0.5	1.6	1.1	1.3	1.3
Angina	0.5	0.7	2.2	0.4	-0.8	-0.1	-1.4	-1.4	-0.8	-0.3	-0.9	-0.0	-1.0	0.5	-0.4	-1.5	-0.8	-0.7	-0.8
Supplements: Zinc	0.5	0.6	3.4	-1.9	0.2	-0.7	1.0	0.6	0.3	-0.5	0.4	-0.2	0.1	-1.5	-0.7	0.8	-0.1	-0.5	-0.4
Medication: Metformin	0.5	0.7	1.9	-0.1	-1.3	0.9	-1.2	-0.9	-0.6	-0.1	-1.0	-0.1	-0.8	-0.5	-0.6	-1.0	-0.3	-0.8	-1.4
Trunk fat percentage	0.5	2.0	5.1	0.2	-2.2	-0.3	-1.9	-1.6	-1.4	-0.4	-2.0	-0.2	-1.3	-0.3	-0.9	-1.6	-1.0	-1.6	-2.2
Hand grip strength (right)	0.5	1.4	5.9	2.4	0.6	-0.6	0.9	1.3	0.3	0.6	0.4	-0.1	1.8	1.4	1.0	1.2	0.8	1.4	1.5
Relative age voice broke	0.5	0.8	7.3	-0.1	-0.5	-2.7	-0.4	-0.3	-1.1	-0.9	-0.7	-1.1	0.2	0.7	0.1	-0.3	-0.7	-0.1	0.4
Serious illness, injury or assault to yourself	0.5	0.6	1.5	1.2	1.0	0.4	1.0	1.1	0.8	0.6	0.8	0.7	1.0	0.1	0.7	1.0	0.1	0.3	0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.4	1.2	1.0	-0.9	0.1	0.6	0.3	0.7	0.5	0.4	1.0	1.1	0.9	0.5	0.7	1.0	0.9
High blood pressure (mother)	0.5	0.7	2.2	-0.0	-0.2	-0.6	0.3	0.7	0.3	0.9	0.2	0.4	1.3	1.5	1.3	0.4	0.8	1.1	1.1
Nervous feelings	0.5	1.0	4.2	1.8	0.6	0.0	0.3	0.3	0.1	0.4	0.5	0.1	1.0	2.1	1.3	-0.0	0.3	1.1	1.7
Hearing difficulty/problems with background noise	0.5	0.9	2.3	0.2	-1.2	0.7	-0.6	-0.9	-0.7	-1.0	-0.4	-0.6	-0.9	-0.6	-1.5	-0.8	-1.5	-1.1	-1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	4.4	0.1	0.4	2.1	0.9	0.8	0.6	0.2	0.6	0.1	0.2	-1.1	-0.3	0.9	0.4	-0.1	-0.5
Mouth/teeth dental problems: Dentures	0.5	0.8	4.2	1.8	0.8	2.0	0.3	0.7	0.5	0.8	1.0	0.5	0.7	0.7	0.4	0.7	0.0	0.4	0.2
Impedance of arm (left)	0.5	2.4	13.8	1.4	0.2	-1.5	-0.2	0.6	-0.3	1.0	-0.3	0.1	2.0	3.7	2.0	0.1	1.0	2.0	2.4
Age at first live birth	0.5	0.9	5.9	-1.6	-0.4	-2.4	0.1	0.2	-0.7	-1.0	-1.0	-1.5	0.1	-0.7	-0.3	0.3	-0.3	0.0	0.2
Whole body fat mass	0.5	2.1	8.0	-0.1	-1.9	0.6	-1.4	-1.4	-1.0	-0.5	-1.6	-0.2	-1.6	-1.5	-1.5	-1.2	-1.1	-2.0	-2.8
Commuting to job workplace: Walk	0.5	0.5	3.5	-0.8	-0.9	-1.9	-0.4	-0.2	-0.4	-0.1	-1.2	-0.4	-0.0	0.3	0.3	-0.5	0.6	0.3	0.4
Eye problems/disorders: Cataract	0.5	0.6	1.2	-0.7	0.0	-0.5	-1.1	-0.9	-0.8	-0.5	-1.1	-0.7	-1.0	-0.5	-0.7	-0.6	-0.8	-0.7	-0.7
Medication: Gliclazide	0.5	0.6	1.9	0.5	-0.5	0.3	-1.4	-1.1	-0.9	-0.2	-0.9	-0.5	-0.9	0.4	-0.3	-1.2	-0.2	-0.4	-0.7
Irritability	0.5	0.9	2.7	1.5	0.8	1.6	0.7	0.9	1.0	1.2	0.5	1.2	1.0	0.2	0.9	0.9	0.5	0.6	0.5
Risk taking	0.5	0.8	3.0	-0.6	0.3	1.6	0.4	-0.0	0.3	-0.9	0.8	-0.6	-0.8	-1.7	-1.3	0.1	-0.7	-0.8	-0.8
Basal cell carcinoma (self-reported)	0.5	0.6	2.2	-0.2	-0.1	-1.5	-0.6	-0.4	-1.2	-0.8	-1.2	-1.1	-0.3	-0.1	-0.7	-0.3	-0.8	-0.6	-0.6
Worry (Nagel 2018)	0.4	0.7	3.3	0.7	0.2	0.5	0.1	0.3	0.2	0.5	0.5	-0.0	0.8	1.8	1.1	0.0	0.6	1.4	1.7
Alzheimer’s Disease (including proxy)	0.4	0.6	1.8	-1.0	-0.4	-0.9	-0.4	-0.4	-0.8	-1.0	-0.6	-1.4	-0.7	-1.2	-1.0	-0.2	-0.6	-0.6	-0.7
Ulcerative Colitis (UC)	0.4	0.7	5.4	-1.6	0.3	-2.3	-0.0	-0.3	0.2	-0.1	-0.5	-0.1	-0.8	-1.0	0.0	-0.1	0.9	0.2	0.3
Ulcerative Colitis	0.4	0.5	2.1	-1.0	-0.0	-1.4	0.3	0.0	0.4	0.5	-0.1	0.5	0.0	0.6	0.9	-0.1	1.4	0.7	1.1
Heel T-Score	0.4	3.5	13.6	2.0	-2.7	-1.8	-2.6	-2.3	-1.7	0.6	-1.5	0.6	-0.5	3.7	1.1	-2.8	-0.1	-0.6	-0.5
Lung FVC	0.4	2.2	6.7	-1.3	2.3	-0.3	2.5	2.2	1.0	-0.5	1.0	-0.8	0.6	-2.6	-0.5	2.6	0.3	-0.0	0.2
Ever had hysterectomy (womb removed)	0.4	0.4	1.5	0.5	0.3	-0.4	-0.0	-0.2	0.4	0.9	-0.1	0.8	0.1	1.1	1.2	-0.4	1.2	0.5	0.8
Age when periods started (menarche)	0.4	1.0	3.5	-1.9	0.6	-1.8	-0.3	-0.3	-0.5	-0.7	-1.3	-0.8	-1.0	-1.6	-0.9	-0.0	-0.4	-0.8	-0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.8	0.4	-0.1	0.4	0.7	0.7	0.7	0.9	0.8	0.8	0.6	0.9	0.7	0.6	0.8	0.7	0.7
Alcohol usually taken with meals	0.4	0.6	1.2	0.3	0.5	1.1	0.7	0.6	0.9	0.9	1.1	0.9	0.6	0.8	0.8	0.5	0.9	0.8	0.8
Qualifications: None of the above	0.4	0.8	2.6	-1.3	0.4	-0.2	-1.0	-1.2	-0.4	-0.5	-0.6	-0.0	-1.6	-1.3	-1.1	-0.9	-0.4	-1.0	-1.1
Impedance of arm (right)	0.4	1.7	10.5	1.1	0.1	-1.9	-0.4	0.2	-0.6	0.6	-0.5	0.1	1.5	3.2	1.7	-0.2	0.6	1.4	2.0
Peak expiratory flow (PEF)	0.4	1.0	2.8	-0.4	1.6	-1.1	1.5	1.4	0.9	0.3	0.8	0.2	0.8	-0.5	0.4	1.7	0.9	0.9	0.9
Medication: Paracetamol	0.4	0.6	1.4	0.2	-1.2	0.3	-0.8	-1.0	-0.8	-0.5	-0.7	-0.4	-0.7	-0.2	-0.8	-1.0	-0.6	-1.0	-1.1
Health satisfaction	0.4	0.5	1.4	0.8	0.2	0.8	0.4	0.7	0.8	1.1	0.5	1.2	0.7	0.4	0.7	0.6	0.5	0.5	0.2
Emphysema/chronic bronchitis	0.4	0.4	1.3	0.5	-0.8	1.1	-0.6	-0.7	-0.3	-0.1	-0.8	0.0	-0.6	-0.2	-0.6	-0.7	-0.4	-0.6	-0.9
Medication: Allopurinol	0.4	0.5	1.6	-1.0	-0.1	-0.7	0.1	-0.3	-0.3	-0.5	-0.7	-0.3	-0.7	-1.3	-0.9	-0.1	-0.4	-1.2	-1.2
Comparative height size at age 10	0.4	2.3	5.6	0.7	0.9	0.1	1.1	1.9	1.7	2.0	0.6	1.5	1.8	0.8	1.5	1.7	2.4	2.1	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-0.8	1.0	-1.1	0.9	0.8	0.6	-0.2	1.1	0.2	0.2	-0.9	-0.2	0.9	0.2	0.1	0.3
Loneliness, isolation	0.4	0.6	1.5	-0.8	-0.4	0.1	-0.7	-0.9	-0.7	-0.7	-0.5	-0.3	-0.7	-0.3	-0.7	-0.9	-1.2	-1.1	-0.9
Long-standing illness, disability or infirmity	0.4	0.6	1.5	0.3	0.8	-1.2	1.0	0.7	0.7	0.4	1.1	0.8	0.8	0.8	0.9	0.5	0.2	0.5	1.1
Average weekly champagne plus white wine intake	0.4	0.5	1.4	-0.7	0.2	1.2	-0.6	-0.6	-0.4	-0.6	-0.3	-0.6	-0.5	-0.9	-0.9	-0.3	-1.0	-0.6	-0.8
Wears glasses or contact lenses	0.4	0.5	1.4	0.2	-0.3	-1.1	-1.1	-0.6	-1.0	-0.1	-1.2	-0.7	-0.0	0.9	0.2	-0.8	-0.1	0.0	-0.1
Ever taken oral contraceptive pill	0.4	0.5	1.5	-1.2	-0.1	0.1	1.0	0.9	0.4	-0.5	0.8	-0.3	0.3	-1.2	-0.5	1.0	-0.6	-0.3	-0.2
High cholesterol (Self-reported)	0.4	0.7	3.7	0.9	-0.3	-0.8	-1.6	-0.9	-0.8	0.6	-0.7	0.3	0.2	1.9	0.3	-0.9	-0.3	0.2	-0.1
Impedance of whole body	0.4	2.1	13.3	1.4	-0.1	-1.8	-0.7	0.0	-0.7	0.6	-0.6	-0.1	1.6	3.6	1.7	-0.4	0.4	1.6	2.1
Bipolar Disorder or Schizophrenia	0.3	0.7	1.8	-0.3	-0.1	-1.1	-0.3	-0.2	-0.7	-0.7	-1.1	-0.4	-0.3	-1.1	-0.8	-0.1	-1.3	-1.3	-1.2
Alzheimer’s Disease (in mother)	0.3	0.4	1.6	-1.1	-0.1	-0.7	-0.0	-0.3	-0.3	-0.7	-0.2	-0.7	-0.8	-1.2	-0.7	-0.1	-0.3	-0.7	-0.7
Blood White Count	0.3	2.0	9.1	1.9	0.2	3.0	0.1	0.1	1.4	2.1	0.8	3.0	0.2	0.4	1.0	0.0	0.7	-0.3	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.2	-0.1	0.6	1.5	-0.4	-0.1	-0.1	-0.1	-0.4	-0.2	-0.3	-1.0	-0.7	0.1	-0.6	-0.5	-1.0
Diabetes (mother)	0.3	0.4	1.3	0.4	-0.4	0.1	-1.1	-1.1	-0.3	0.2	0.1	0.7	-0.5	1.0	0.0	-1.1	-0.4	-0.4	-0.4
Severe depression (siblings)	0.3	0.3	0.8	0.1	-0.5	-0.3	-0.9	-0.8	-0.5	-0.0	-0.7	0.2	-0.8	0.2	-0.3	-0.8	-0.3	-0.6	-0.6
Chronic bronchitis/emphysema (father)	0.3	0.4	1.4	-0.8	1.2	-0.9	0.3	0.6	0.6	0.4	0.6	0.7	0.4	-0.3	0.2	0.6	0.2	0.4	0.2
Impedance of leg (left)	0.3	1.3	7.4	0.6	-0.9	-1.4	-1.5	-0.9	-1.3	-0.3	-1.0	-0.7	0.5	2.7	0.7	-1.3	-0.5	0.7	1.1
Trunk fat mass	0.3	1.3	4.9	0.1	-1.8	0.3	-1.2	-1.0	-0.8	-0.2	-1.5	-0.1	-1.1	-1.0	-1.0	-1.0	-0.7	-1.5	-2.2
Trunk fat-free mass	0.3	1.6	4.0	0.5	0.6	1.7	2.0	1.8	1.6	0.6	1.3	0.5	0.6	-1.9	-0.2	2.0	1.2	0.6	0.0
Hip circumference	0.3	1.2	4.9	-0.0	-1.2	1.3	-0.8	-0.8	-0.5	-0.3	-0.8	-0.2	-1.2	-1.7	-1.2	-0.6	-0.9	-1.5	-2.2
Alcohol intake versus 10 years previously	0.3	0.4	2.2	0.1	1.0	1.0	-0.2	0.0	0.6	1.0	0.3	1.5	-0.4	-0.3	-0.1	0.2	0.6	-0.1	-0.7
Father’s age at death	0.3	0.4	2.0	-0.9	0.5	-1.4	0.5	0.0	0.2	-0.4	0.8	-0.2	0.1	0.3	0.4	0.1	0.2	0.7	1.3
Falls in the last year	0.3	0.5	5.8	-0.4	0.2	-2.4	0.4	0.2	-0.1	-0.3	0.3	-0.3	0.3	0.3	0.2	0.1	-0.0	0.4	0.7
Number of live births	0.3	0.4	1.6	0.3	-1.3	0.1	-0.9	-0.8	-0.8	-0.2	-0.1	-0.2	-0.3	0.6	-0.5	-0.7	-0.9	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	4.1	-1.0	-0.4	-0.1	0.2	-0.1	-0.8	-1.5	-0.6	-2.0	-0.9	-1.8	-1.4	0.2	-0.6	-0.8	-0.8
Illnesses of mother	0.3	0.4	1.5	0.0	0.5	0.8	1.2	0.7	0.7	-0.4	1.0	-0.1	0.1	-0.9	-0.5	0.7	0.0	-0.0	0.3
Trunk predicted mass	0.3	1.5	4.0	0.5	0.6	1.6	2.0	1.7	1.6	0.5	1.3	0.4	0.5	-1.9	-0.3	2.0	1.1	0.5	-0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	3.0	1.7	-0.4	1.5	-0.4	-0.3	-0.1	0.5	-0.3	0.3	-0.2	0.7	0.1	-0.3	0.2	0.0	-0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	2.0	-1.4	-0.5	-0.7	-0.2	-0.2	-0.5	-0.7	-0.3	-0.8	-0.3	-0.7	-0.3	-0.1	-0.8	-0.5	-0.4
Forced vital capacity (FVC), Best measure	0.3	1.1	4.3	-0.1	1.2	0.2	1.9	1.9	0.8	-0.1	0.7	-0.7	0.9	-1.0	-0.1	2.1	0.7	0.7	0.7
Number of full brothers	0.3	0.4	1.6	0.5	-1.3	1.0	-0.9	-0.5	-0.6	0.0	-0.4	-0.3	-0.4	0.7	-0.1	-0.8	-0.0	-0.4	-0.7
Eye problems/disorders: None of the above	0.3	0.3	1.2	1.1	-0.3	0.7	0.4	0.6	0.1	0.4	0.2	0.3	0.9	0.9	0.4	0.4	0.1	0.3	0.2
Family relationship satisfaction	0.3	0.4	1.9	-0.9	0.2	0.7	0.3	-0.0	0.3	-0.5	0.4	0.2	-0.4	-1.4	-0.9	0.2	-0.7	-0.9	-0.8
Leg pain on walking	0.3	0.4	1.3	0.5	-0.8	1.1	-0.4	-0.9	-0.0	-0.1	0.0	0.5	-0.8	0.1	-0.5	-0.9	-0.3	-0.6	-0.6
Knee pain experienced in last month	0.3	0.5	1.3	1.1	0.6	-0.2	0.3	0.2	0.5	0.8	0.5	1.1	0.7	1.0	1.0	0.1	0.7	0.5	0.7
Average weekly red wine intake	0.3	0.5	1.6	-0.6	-1.0	0.1	-1.0	-0.8	-0.3	-0.0	-0.7	-0.1	-0.8	-0.9	-0.5	-0.7	0.1	-0.6	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.4	-0.6	-0.9	-0.8	-0.8	-0.4	0.0	-0.9	0.0	-0.6	0.1	-0.2	-0.8	0.5	-0.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	4.9	-0.8	-0.7	-2.2	-0.2	0.0	-0.3	-0.0	-0.5	0.1	0.6	0.8	0.6	-0.2	-0.1	0.3	0.6
Asthma (self-reported)	0.3	0.5	1.5	-0.1	0.6	-1.0	1.2	1.0	0.7	0.5	0.2	0.6	0.8	0.1	0.7	0.9	0.8	0.4	0.7
Osteoporosis (self-reported)	0.3	0.4	1.4	0.3	1.2	-0.6	-0.7	-0.6	-0.6	-0.7	-0.5	-0.5	-0.6	-0.4	-0.6	-0.5	-1.0	-0.4	-0.3
Illnesses of father: High blood pressure	0.3	0.4	1.2	1.0	-0.7	0.1	-1.1	-0.4	-0.8	-0.1	-0.4	-0.7	0.2	0.9	0.0	-0.5	-0.7	-0.0	-0.3
Pain experienced in last month	0.3	0.6	3.0	-1.1	0.1	1.1	0.1	0.2	-0.0	-0.6	-0.3	-0.6	-0.5	-1.7	-0.9	0.3	-0.6	-0.6	-0.8
Neuroticism (2016)	0.2	0.3	0.9	0.5	0.4	0.4	0.7	0.6	0.5	0.4	1.0	0.6	0.9	0.4	0.3	0.6	0.3	0.2	0.3
Schizophrenia (2014)	0.2	0.4	0.8	0.4	-0.6	-0.9	-0.8	-0.4	-0.8	-0.4	-0.9	-0.4	-0.1	0.2	-0.3	-0.6	-0.9	-0.6	-0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	0.7	0.1	0.6	-0.3	-0.1	0.3	0.5	0.7	0.7	0.3	0.8	0.3	-0.2	0.0	0.2	0.0
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.3	0.1	0.8	-0.8	-0.7	-0.3	-0.1	0.0	-0.1	-0.5	-0.1	-0.1	-0.5	-0.3	-0.3	-0.4
Impedance of leg (right)	0.2	1.1	7.1	0.5	-0.6	-1.6	-1.0	-0.6	-1.0	-0.1	-0.8	-0.5	0.6	2.7	0.8	-0.9	-0.2	0.8	1.3
Leg fat-free mass (left)	0.2	0.9	4.6	0.3	-0.0	1.5	1.3	1.0	0.9	0.2	0.4	0.1	-0.1	-2.1	-0.8	1.2	0.5	-0.4	-1.0
Townsend deprivation index at recruitment	0.2	0.3	1.2	-0.4	-0.9	0.5	0.1	-0.2	-0.1	-0.4	-0.1	0.1	-0.4	-1.0	-0.6	-0.1	-0.6	-1.1	-1.0
Average weekly fortified wine intake	0.2	0.3	0.6	0.5	0.3	-0.3	0.4	0.8	0.3	0.6	0.1	0.2	0.8	0.7	0.4	0.7	0.3	0.5	0.4
Medication: Levothyroxine sodium	0.2	0.4	2.3	-0.1	0.6	-1.5	-0.2	0.1	0.0	0.4	-0.0	0.2	0.3	0.8	0.9	-0.0	0.7	0.8	1.0
Leg predicted mass (left)	0.2	0.9	4.8	0.3	-0.1	1.4	1.2	1.0	0.8	0.1	0.3	0.0	-0.1	-2.2	-0.8	1.2	0.4	-0.5	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.7	0.3	0.2	1.3	-0.0	0.0	0.4	0.5	0.6	0.5	0.3	0.7	0.5	-0.0	0.2	0.5	0.5
Had other major operations	0.2	0.3	0.9	0.6	-0.4	0.9	0.1	-0.4	0.1	-0.0	0.0	0.3	-0.8	-0.5	-0.5	-0.3	0.2	-0.8	-0.8
Forced vital capacity (FVC)	0.2	0.9	4.1	-1.0	0.4	0.3	1.3	1.0	0.1	-1.0	0.1	-1.5	-0.1	-2.0	-1.1	1.3	-0.2	-0.3	-0.4
Pain all over the body in last month	0.2	0.2	0.9	0.5	1.0	0.3	0.1	0.2	0.4	0.6	0.3	0.5	0.2	0.0	0.3	0.4	0.4	0.3	0.0
Weight	0.2	1.0	4.2	0.5	-1.5	1.4	-0.6	-0.6	-0.3	-0.1	-0.9	-0.1	-1.0	-1.5	-1.1	-0.5	-0.3	-1.2	-2.0
Hair/balding pattern: Pattern 3	0.2	0.3	1.7	-1.0	1.3	0.4	0.4	0.5	0.4	-0.0	0.5	-0.2	0.1	-0.9	0.0	0.8	0.1	0.3	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.6	1.2	-0.4	1.2	-0.4	-0.1	0.2	0.6	-0.4	0.3	0.0	0.8	0.6	-0.3	0.7	0.7	0.4
Asthma	0.2	0.3	0.9	-0.2	0.2	-0.9	0.9	0.8	0.5	0.4	0.0	0.5	0.6	0.1	0.6	0.6	0.6	0.3	0.5
Tense / ‘highly strung’	0.2	0.3	1.4	0.6	-0.3	1.1	-0.2	0.0	-0.0	0.3	0.2	0.2	0.6	1.2	0.4	-0.1	-0.1	0.5	0.5
Arm fat-free mass (right)	0.2	0.9	4.8	0.3	-0.2	1.7	1.1	0.9	0.9	0.1	0.5	0.1	-0.1	-2.2	-0.8	1.1	0.4	-0.3	-1.0
Comparative body size at age 10	0.2	0.5	1.2	-1.1	0.8	-0.6	0.5	0.8	0.8	0.6	0.5	0.5	0.6	-0.4	0.5	0.8	0.8	0.9	0.6
Wheeze or whistling in the chest in last year	0.2	0.4	1.3	0.2	-0.0	0.9	-0.4	-0.5	-0.1	-0.0	-0.7	0.4	-0.8	-0.6	-0.4	-0.6	-0.5	-1.1	-1.2
Number of children fathered	0.2	0.2	0.6	-0.5	0.8	-0.0	0.4	0.1	0.7	0.5	0.2	0.8	-0.4	-0.4	0.2	0.1	0.8	-0.1	0.1
Qualifications: College or University degree	0.2	0.5	1.3	0.7	0.7	1.0	0.5	0.9	0.7	0.9	0.1	0.3	0.7	0.2	0.8	0.8	1.2	0.8	0.6
Medication: Ibuprofen	0.2	0.3	0.9	-0.9	0.1	0.6	0.1	-0.3	0.2	-0.2	0.1	0.1	-0.6	-1.0	-0.7	-0.1	-0.2	-0.7	-0.7
Medication: Omeprazole	0.2	0.3	1.8	-0.3	-0.2	-1.3	-0.3	-0.6	-0.3	-0.6	0.2	-0.0	-0.4	-0.2	-0.6	-0.4	-0.7	-0.7	-0.5
Arm predicted mass (right)	0.2	0.9	5.4	0.2	-0.2	1.7	1.1	0.9	0.9	0.1	0.4	0.1	-0.2	-2.3	-0.8	1.1	0.5	-0.4	-1.0
Suffer from ‘nerves’	0.2	0.3	1.5	0.1	0.5	0.0	0.9	0.5	0.4	-0.2	0.9	-0.2	0.5	0.6	0.3	0.5	0.3	0.7	1.2
Overall health rating	0.2	0.4	2.0	-0.4	-0.4	1.4	-0.4	-0.7	-0.1	-0.1	0.2	0.3	-0.7	-0.4	-0.5	-0.6	-0.6	-0.8	-1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.2	-0.2	0.8	1.1	-0.2	0.2	0.4	0.5	0.7	0.4	-0.1	-0.1	-0.1	0.4	0.2	0.4	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	2.3	-0.3	-0.8	-0.2	-0.4	-0.1	-1.0	-0.9	-0.9	-1.5	-0.2	-0.2	-0.9	-0.1	-0.4	-0.3	-0.5
Whole body fat-free mass	0.2	1.2	4.4	0.4	0.2	1.7	1.6	1.4	1.3	0.4	0.8	0.3	0.3	-2.1	-0.5	1.6	0.8	0.1	-0.5
Friendships satisfaction	0.2	0.2	1.4	-1.2	-0.0	0.2	0.4	0.1	0.0	-0.5	0.3	-0.3	-0.2	-0.9	-0.3	0.2	-0.4	-0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.1	-0.5	0.7	-1.0	0.2	0.2	-0.1	-0.6	0.3	-0.6	0.1	-0.7	-0.3	0.3	-0.2	0.2	0.3
Back pain experienced in last month	0.2	0.3	0.7	-0.7	-0.2	-0.2	-0.5	-0.8	-0.4	-0.7	-0.3	-0.6	-0.8	-0.3	-0.6	-0.7	-0.4	-0.5	-0.3
Osteoarthritis (self-reported)	0.2	0.2	0.7	0.1	-0.1	0.7	0.3	0.0	0.4	0.4	0.5	0.6	0.3	0.9	0.6	-0.0	0.4	0.3	0.6
Illnesses of father: None of the above (group 1)	0.2	0.2	0.7	-0.8	0.8	0.1	0.8	0.2	0.4	-0.2	0.3	0.3	-0.0	-0.8	-0.1	0.4	0.1	-0.5	-0.1
Whole body water mass	0.2	1.2	5.2	0.3	0.2	1.7	1.6	1.4	1.2	0.3	0.8	0.2	0.2	-2.3	-0.6	1.6	0.8	-0.0	-0.6
Basal metabolic rate	0.2	0.9	4.6	0.4	-0.3	1.7	1.1	0.8	0.8	0.1	0.3	0.1	-0.2	-2.1	-0.8	1.1	0.4	-0.4	-1.1
Arm fat-free mass (left)	0.2	0.9	5.8	0.2	-0.1	1.4	1.1	0.8	0.9	0.0	0.4	0.2	-0.3	-2.4	-0.9	1.1	0.3	-0.5	-1.1
Unable to work because of sickness or disability	0.2	0.3	0.7	0.1	0.8	-0.2	0.0	0.0	0.5	0.6	0.7	0.7	0.2	0.5	0.5	0.1	0.9	0.6	0.5
Cholesterol lowering medication	0.2	0.4	1.1	0.8	-0.9	-0.3	-1.1	-1.0	-0.5	0.1	-0.5	0.2	-0.3	0.7	0.0	-1.0	-0.4	-0.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.5	-0.4	0.0	-1.2	0.0	-0.2	-0.2	-0.5	0.3	-0.2	-0.2	-0.3	-0.5	-0.1	-0.5	-0.5	-0.3
Arm predicted mass (left)	0.2	0.8	5.4	0.1	-0.3	1.4	1.0	0.7	0.9	0.1	0.4	0.2	-0.3	-2.3	-0.9	1.0	0.3	-0.5	-1.1
Depressed Affect (Nagel 2018)	0.1	0.3	2.1	-0.3	-0.5	1.4	-0.7	-0.7	-0.1	0.3	-0.4	0.2	-0.4	0.5	-0.0	-0.7	-0.1	-0.3	-0.4
Neuroticism (Nagel 2018)	0.1	0.2	1.3	0.3	-0.4	1.1	-0.6	-0.4	-0.4	0.1	-0.4	-0.4	0.2	1.0	0.0	-0.4	-0.4	0.0	0.1
Neuroticism	0.1	0.2	0.7	0.8	0.2	0.9	0.0	-0.0	-0.1	-0.2	0.2	-0.4	0.3	0.8	0.0	-0.2	-0.5	0.3	0.4
Tanning	0.1	1.3	4.0	-1.3	1.6	0.7	1.8	1.3	1.0	-0.1	0.9	-0.2	-0.2	-2.0	-0.9	1.8	0.8	-0.1	-0.2
Sensitivity / hurt feelings	0.1	0.3	1.5	1.0	0.1	0.6	-0.1	-0.1	-0.1	0.1	0.4	-0.0	0.5	1.2	0.1	-0.2	-0.5	0.4	0.5
Hearing difficulty/problems: Yes	0.1	0.2	0.7	0.5	-0.8	-0.8	-0.4	-0.0	-0.4	0.0	0.2	0.1	0.5	0.8	0.1	-0.2	-0.4	0.2	-0.0
Fed-up feelings	0.1	0.2	0.6	-0.6	-0.1	0.8	0.1	-0.5	-0.0	-0.3	0.1	0.2	-0.6	-0.5	-0.5	-0.4	-0.4	-0.8	-0.6
Qualifications: CSEs or equivalent	0.1	0.2	0.8	-0.8	-0.9	-0.0	-0.2	-0.3	-0.4	-0.3	0.1	-0.1	0.1	0.4	-0.5	-0.3	-0.4	-0.4	-0.4
Mouth/teeth dental problems	0.1	0.2	0.5	0.0	-0.2	-0.6	-0.6	-0.6	-0.2	0.1	-0.6	0.1	-0.4	0.4	0.1	-0.7	0.6	0.3	0.3
Neuroticism score	0.1	0.3	1.4	1.1	0.1	1.2	-0.2	-0.3	-0.1	0.1	0.1	0.1	0.3	1.0	0.2	-0.4	-0.7	0.0	0.2
Time employed in main current job	0.1	0.1	0.6	-0.5	-0.8	0.3	-0.4	-0.4	-0.3	-0.2	-0.4	-0.3	-0.2	-0.0	-0.0	-0.5	-0.4	-0.3	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.9	0.7	0.2	0.4	-0.3	-0.1	0.0	0.6	-0.1	0.4	0.2	0.9	0.5	-0.1	0.1	0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.5	-0.3	0.2	-0.1	0.8	0.7	-0.1	-0.6	-0.1	-1.2	0.1	-1.0	-0.5	0.9	0.3	0.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	1.0	-0.2	-0.1	1.0	0.2	0.3	0.1	0.1	0.2	-0.0	0.1	-0.1	-0.3	0.3	-0.1	-0.2	-0.4
Headache pain in last month	0.1	0.1	0.3	-0.3	0.2	-0.5	0.4	0.5	0.2	0.4	0.2	0.4	0.5	0.5	0.5	0.4	0.3	0.1	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.6	0.1	-0.5	0.8	0.3	0.2	0.1	0.0	-0.1	0.1	0.1	0.2	0.1	-0.0	-0.1	-0.2	-0.1
Birth weight	0.1	0.3	1.3	0.7	0.4	-0.9	-0.6	-0.1	-0.2	0.5	-1.1	-0.1	-0.0	0.5	0.4	-0.2	0.7	0.5	0.3
Migraine (self-reported)	0.1	0.2	0.7	-0.8	-0.0	-0.7	0.8	0.3	0.2	-0.4	0.2	-0.2	0.0	-0.8	-0.0	0.4	0.1	-0.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.7	0.3	0.2	-0.1	0.6	0.4	0.3	0.0	0.9	0.2	0.3	0.0	0.1	0.4	0.0	0.1	0.2
Leg fat-free mass (right)	0.1	0.8	4.3	0.4	-0.1	1.5	1.1	0.9	0.7	0.0	0.3	-0.1	-0.1	-2.1	-0.8	1.1	0.3	-0.4	-1.0
Mood swings	0.1	0.2	2.0	0.4	-0.4	1.4	-0.1	-0.1	0.3	0.4	0.2	0.5	0.0	0.2	0.1	-0.3	0.3	0.1	-0.2
Leg predicted mass (right)	0.1	0.8	4.5	0.3	-0.2	1.5	1.1	0.9	0.7	-0.0	0.3	-0.1	-0.1	-2.1	-0.8	1.1	0.3	-0.4	-1.0
Tinnitus: Yes, now most or all of the time	0.1	0.2	1.2	0.5	0.1	-1.1	-0.2	0.3	-0.1	0.3	-0.6	0.1	0.4	0.1	0.3	0.3	0.1	0.2	0.0
Schizophrenia (2018)	0.0	0.1	0.4	0.6	0.0	-0.6	0.1	0.3	-0.1	-0.0	0.3	-0.0	0.5	0.3	0.0	0.2	-0.5	-0.1	-0.1
Hair Pigment	0.0	0.8	2.9	1.7	0.8	1.1	0.1	0.5	1.1	1.4	0.6	1.3	0.4	0.2	1.0	0.4	1.0	0.9	0.2

Hub : Genes

CYP3A5

Models

Trait associations