Hub : Genes

DBH-AS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.140 0.0470 1.6e-03 -0.003 NA 0.001 NA -0.002 8.7e-01 NA 2.6e-01 NA 5.3e-01
2 GTEx Colon Transverse 0.323 0.0790 2.7e-04 0.193 NA 0.158 NA 0.186 1.5e-09 NA 5.7e-08 NA 3.1e-09
3 GTEx Esophagus Gastroesophageal Junction 0.386 0.1050 9.3e-04 0.160 NA 0.053 NA 0.104 2.1e-06 NA 5.5e-03 NA 1.4e-04
4 GTEx Esophagus Muscularis 0.207 0.0640 2.0e-03 0.195 NA 0.170 NA 0.194 5.3e-12 NA 1.6e-10 NA 5.8e-12
5 GTEx Liver 0.330 0.1100 3.4e-03 0.141 NA 0.017 NA 0.130 9.9e-05 NA 1.1e-01 NA 1.8e-04
6 GTEx Nerve Tibial 0.393 0.0621 2.2e-08 0.038 NA 0.159 NA 0.175 1.0e-03 NA 2.4e-11 NA 1.8e-12
7 GTEx Pancreas 0.284 0.0720 3.2e-04 0.063 NA 0.068 NA 0.047 1.2e-03 NA 8.3e-04 NA 4.6e-03
8 GTEx Skin Sun Exposed Lower leg 0.123 0.0410 1.5e-03 0.030 NA 0.023 NA 0.029 1.4e-03 NA 4.9e-03 NA 1.7e-03
9 GTEx Testis 0.468 0.0850 6.8e-05 0.275 NA 0.181 NA 0.242 1.2e-12 NA 1.9e-08 NA 4.1e-11
10 GTEx Whole Blood 0.141 0.0560 7.5e-03 0.073 NA 0.048 NA 0.064 2.8e-07 NA 2.8e-05 NA 1.5e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.1 0.1 0.4 0.0 0.2 -0.4 0.6 0.2 0.4 0.4 -0.2 -0.2 -0.4
Bipolar Disorder or Schizophrenia 0.2 0.4 1.3 0.0 0.9 0.3 0.6 0.6 0.2 -0.5 0.5 1.1 0.7
Depressed Affect (Nagel 2018) 0.3 0.6 2.0 0.0 -0.1 -0.9 -0.9 0.2 0.0 0.4 1.4 0.7 1.1
Depression (Nagel 2018) 1.4 2.1 5.5 0.0 0.6 0.2 -0.0 1.2 2.4 0.9 2.1 1.8 2.2
Intelligence (Savage-Jansen 2018) 0.3 1.0 2.4 0.0 0.2 1.3 1.5 1.0 1.5 0.8 1.0 0.7 0.6
Neuroticism (Nagel 2018) 0.4 0.9 4.0 0.0 0.1 1.2 0.7 -0.6 -0.2 -0.4 2.0 0.9 1.5
Schizophrenia (2018) 0.4 0.9 3.4 0.0 1.0 0.7 0.4 0.6 0.1 -0.8 0.6 1.9 1.5
Schizophrenia vs Biploar Disorder 0.1 0.2 1.0 0.0 1.0 0.3 0.2 0.6 0.0 0.6 0.0 0.0 0.0
Worry (Nagel 2018) 0.6 1.2 4.2 0.0 -0.6 2.1 0.9 -0.9 -0.8 -1.3 1.4 0.6 1.3
Alzheimer’s Disease (in mother) 3.3 3.9 9.7 0.0 2.6 2.7 3.1 1.2 1.9 1.3 1.2 1.8 1.8
Alzheimer’s Disease (in father) 0.9 1.0 6.4 0.0 0.4 -0.7 0.1 1.4 -0.2 2.5 -0.6 0.7 0.6
Alzheimer’s Disease (including proxy) 1.3 1.9 3.4 0.0 1.6 1.5 1.7 1.0 1.1 1.1 0.9 1.8 1.8
Crohns Disease (2017) 0.6 1.3 2.9 0.0 -0.7 -1.7 -1.0 -1.4 -1.7 0.6 0.0 -1.5 -1.3
Irritable Bowel Disease (IBD) 0.4 1.0 2.2 0.0 -0.1 -1.0 -0.4 -1.2 -1.5 1.3 0.3 -1.4 -1.3
Ulcerative Colitis (UC) 0.2 0.3 1.7 0.0 0.4 -0.4 0.1 -0.6 -0.5 1.3 0.1 -0.4 -0.5
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.1 0.2 0.7 0.0 0.6 0.4 0.5 0.6 0.0 -0.4 -0.9 -0.0 -0.1
Verbal and Numeric Reasoning (VNR) 0.6 1.5 3.2 0.0 -0.4 1.2 0.8 1.4 1.2 -0.1 1.8 1.8 1.7
Breast Cancer 0.3 0.6 3.6 0.0 0.3 1.9 0.9 0.0 0.6 -0.2 1.0 -0.5 -0.5
Ovarian Cancer 0.5 0.7 4.8 0.0 0.7 0.4 -0.0 -2.2 0.0 0.9 0.5 -0.2 0.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.8 1.1 4.2 0.0 0.4 0.1 -0.0 -2.0 -0.1 0.4 -1.8 -1.3 -1.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.3 5.3 0.0 -0.2 -0.4 -0.5 -1.0 -2.3 0.1 -1.5 -1.5 -1.4
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.4 0.6 2.4 0.0 0.3 0.2 -0.1 -1.5 0.0 0.4 -1.1 0.0 -1.5
Mean Putamen Volume 0.4 0.4 2.8 0.0 0.7 0.1 0.6 -0.1 0.1 1.7 0.6 -0.5 -0.4
Fasting Glucose 3.1 3.7 10.8 0.0 0.4 0.7 1.1 2.3 1.9 0.6 2.2 3.2 3.3
HbA1C 1.8 2.0 8.0 0.0 -0.3 -1.3 -0.9 -2.8 -1.3 -1.1 -1.9 -1.4 -1.1
HDL Cholesterol 0.5 0.8 1.8 0.0 0.2 1.1 0.5 0.7 1.2 -0.3 1.0 1.3 1.3
LDL Cholesterol 0.5 0.8 3.3 0.0 0.5 -1.8 -0.5 0.2 -1.5 -0.8 -0.5 -0.5 -0.7
Lupus 2.3 3.4 11.8 0.0 3.4 2.0 2.9 -0.8 -0.2 3.0 -0.1 -0.5 -0.3
Neuroticism (2016) 0.3 0.4 1.0 0.0 -0.7 -0.7 -0.9 0.2 0.1 -1.0 0.6 0.7 0.8
Primary Biliary Cirrhosis 0.4 0.6 1.6 0.0 0.8 0.3 0.9 1.2 0.8 1.3 0.3 0.7 0.6
Rheumatoid Arthritis 0.5 0.7 2.3 0.0 0.2 0.8 1.0 -0.2 1.0 0.1 0.4 1.5 1.3
Schizophrenia (2014) 0.1 0.2 0.6 0.0 0.7 0.2 0.2 0.4 -0.0 -0.8 -0.4 0.4 -0.0
Triglycerides 0.1 0.2 1.2 0.0 0.6 -0.3 0.6 0.1 0.0 1.1 0.1 -0.4 -0.1
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.1 0.2 0.4 0.0 0.3 -0.3 -0.2 -0.5 -0.6 0.6 0.3 -0.4 -0.3
Blood Eosinophil Count 0.2 1.7 4.8 0.0 -0.8 1.4 1.2 0.8 1.9 2.2 -0.3 1.5 1.2
Blood Platelet Count 0.3 3.3 11.3 0.0 -2.4 -2.6 -3.4 0.9 -2.7 -0.6 0.4 -0.7 -0.4
Blood Red Count 0.8 7.8 39.1 0.0 1.1 0.0 1.7 0.8 6.2 5.8 -0.2 0.8 0.2
Blood White Count 0.4 2.6 7.7 0.0 -0.3 1.0 0.5 0.1 2.8 2.5 0.5 2.5 2.0
Heel T-Score 0.2 1.6 7.3 0.0 -0.8 0.3 0.0 1.6 2.7 1.8 -0.0 1.1 0.9
BMI 0.2 1.0 3.1 0.0 -1.1 -1.0 -1.2 0.1 -1.8 -1.0 -1.0 -0.7 -0.9
Height 0.2 3.7 22.9 0.0 1.4 -0.1 -0.0 2.2 4.8 1.9 0.1 1.6 1.2
Waist Hip Ratio (WHR) 0.1 0.5 2.6 0.0 -0.6 -0.4 -0.4 -0.3 1.2 -1.6 0.6 0.4 0.5
Systolic Blood Pressure 0.2 0.8 5.0 0.0 0.4 -0.1 0.1 0.8 2.2 -0.3 -1.0 0.9 0.5
Smoking Status 0.8 2.0 5.2 0.0 1.7 2.3 2.3 -0.3 1.4 1.7 -1.3 0.4 -0.1
Allergy or Eczema 0.1 0.2 0.8 0.0 0.2 -0.9 -0.4 -0.6 -0.1 -0.2 -0.6 0.6 -0.1
Cardiovascular Disease 0.3 1.1 3.9 0.0 1.9 0.5 1.3 -0.3 0.5 0.7 -2.0 -0.3 -0.5
Hypothyroidism (self reported) 0.1 0.3 2.1 0.0 -0.2 -0.2 -0.5 0.2 -0.6 -1.4 -0.6 0.1 -0.2
Respiratory disease 0.3 0.6 2.7 0.0 -1.1 0.4 -0.5 -1.1 -0.4 -1.6 -0.6 0.2 0.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.8 0.0 1.7 0.9 0.6 0.0 -1.4 0.8 -0.5 -0.6 -0.8
Lung FEV1/FVC ratio 0.6 2.8 8.0 0.0 -1.7 -1.6 -0.7 -0.2 -2.7 1.0 -0.1 -2.8 -2.4
Lung FVC 0.4 1.8 6.2 0.0 -1.4 -0.8 -2.1 -0.1 2.5 -0.9 -0.1 1.5 1.4
Neuroticism 0.3 0.8 2.5 0.0 -0.8 -0.3 -0.6 -0.0 -1.1 -0.9 1.2 1.2 1.6
Chronotype (morning person) 0.2 0.5 1.7 0.0 0.1 0.5 0.9 -0.1 1.3 0.3 0.6 0.9 0.8
Hair Pigment 0.0 0.6 1.2 0.0 0.8 1.1 0.9 1.1 -0.6 0.6 -1.0 0.0 -0.4
Tanning 0.0 0.5 1.6 0.0 1.2 0.8 0.4 -0.5 -0.2 0.3 0.3 -0.9 -1.0
Hand grip strength (left) 0.8 2.2 12.2 0.0 -0.7 -0.9 -1.0 0.3 3.5 -0.6 0.4 2.0 1.6
Number of treatments/medications taken 0.6 1.2 3.0 0.0 1.3 1.7 1.0 -0.7 -0.8 0.2 -1.3 -0.9 -1.5
Average weekly spirits intake 0.3 0.4 1.2 0.0 0.8 0.8 1.0 0.7 -0.1 0.0 0.4 -1.1 -0.5
Sensitivity / hurt feelings 0.3 0.5 1.2 0.0 -0.9 0.5 -0.1 -0.9 -1.1 -0.7 1.0 -0.3 0.3
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.0 0.0 -0.1 0.5 0.2 0.7 0.8 0.4 1.4 0.8 1.0
Hearing difficulty/problems: Yes 0.6 0.9 3.4 0.0 -0.6 -0.0 -0.1 1.8 1.4 0.3 0.7 1.3 1.0
Relative age of first facial hair 0.3 0.7 1.7 0.0 -1.1 -1.3 -1.0 0.7 -0.6 -0.3 1.2 -0.7 -0.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 1.3 0.0 -1.1 -0.1 -0.9 -0.4 -0.6 -0.0 0.4 -0.6 -0.4
Ever used hormone-replacement therapy (HRT) 1.1 1.5 5.6 0.0 1.0 2.4 2.3 0.2 0.1 -0.1 1.3 0.6 0.6
Ever had hysterectomy (womb removed) 1.6 1.8 3.8 0.0 0.1 -0.2 -0.7 -1.9 -1.4 -0.7 -1.9 -2.0 -1.9
Systolic blood pressure, automated reading 0.2 0.7 1.7 0.0 0.6 1.3 1.3 1.2 1.0 -0.3 0.3 0.6 0.4
Eye problems/disorders: Diabetes related eye disease 2.7 3.0 6.5 0.0 2.4 1.0 2.1 -2.3 -0.2 2.5 -2.4 -0.8 -1.1
Angina 0.1 0.1 0.4 0.0 -0.3 0.2 -0.3 -0.4 0.6 -0.4 0.2 -0.1 0.0
Medication for hormone replacement therapy 0.4 0.5 1.6 0.0 0.9 1.3 0.4 -0.4 -0.8 0.6 0.6 -0.7 -0.6
Vitamin and mineral supplements 0.3 0.4 1.6 0.0 0.9 -0.2 -0.1 -0.4 -1.2 0.3 -0.5 -0.8 -0.4
Supplements: Zinc 0.1 0.1 0.3 0.0 -0.4 -0.4 -0.0 -0.1 -0.1 -0.3 0.6 -0.0 -0.2
Medication: Co-codamol 0.8 1.0 5.2 0.0 0.4 2.3 1.6 0.9 0.4 -0.6 0.3 0.6 0.2
Medication: Metformin 1.2 1.7 4.3 0.0 1.1 0.8 0.8 -0.7 -2.0 -1.0 -1.2 -2.1 -1.9
Diabetes (father) 0.3 0.4 2.2 0.0 -0.3 0.4 0.5 0.0 -1.5 0.1 0.6 -0.6 -0.4
Diabetes (mother) 0.5 0.7 2.4 0.0 -1.3 0.1 -0.7 0.4 -1.1 -1.6 -0.2 -0.5 -0.6
Severe depression (siblings) 0.3 0.4 1.5 0.0 0.7 0.2 0.5 0.1 -0.1 -0.2 -1.2 1.1 0.5
Pack years adult smoking proportion 1.5 2.2 9.1 0.0 0.7 1.4 0.7 0.8 3.0 0.7 -0.5 2.4 1.9
Impedance of leg (right) 0.8 3.8 9.9 0.0 1.2 3.1 2.5 0.9 2.8 1.1 1.4 2.1 2.2
Leg fat-free mass (left) 0.2 0.9 3.1 0.0 -0.8 -1.7 -1.6 0.8 -0.3 -0.4 -0.9 -0.5 -0.6
Trunk fat percentage 0.2 0.7 1.7 0.0 0.9 0.9 0.7 -0.0 -1.1 -0.1 -0.9 -1.3 -1.2
Hand grip strength (right) 0.7 1.8 10.2 0.0 -1.3 -0.9 -0.8 0.1 3.2 -0.8 -0.1 1.6 1.2
Townsend deprivation index at recruitment 0.2 0.3 0.9 0.0 1.0 0.7 0.2 0.3 -0.9 -0.4 0.0 -0.6 -0.5
Current tobacco smoking 1.6 2.6 6.1 0.0 1.8 2.2 2.1 0.7 2.5 0.7 -1.0 1.8 1.3
Average weekly fortified wine intake 0.9 1.1 2.9 0.0 1.0 0.5 0.7 0.5 1.7 1.3 0.7 1.2 1.3
Maternal smoking around birth 0.5 0.8 2.0 0.0 1.3 1.1 0.4 -1.4 0.9 -0.8 -0.4 -0.8 -0.7
Fed-up feelings 0.1 0.2 1.1 0.0 -0.2 -0.5 -0.3 1.0 -0.1 -0.0 0.0 0.2 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 2.8 0.0 -0.6 0.1 -0.9 0.6 0.5 0.1 1.7 -0.0 0.4
Relative age voice broke 0.7 1.0 2.2 0.0 -1.4 -1.1 -1.0 1.5 -0.7 -0.2 1.4 0.3 1.1
Taking other prescription medications 0.2 0.4 1.2 0.0 0.7 0.6 -0.0 -0.6 -0.6 0.1 -1.1 -0.5 -0.9
Age when periods started (menarche) 0.9 2.1 8.1 0.0 0.2 0.1 0.3 -2.9 -2.1 0.3 -1.6 -1.6 -1.8
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 4.9 0.0 2.2 1.0 1.4 -2.0 -0.3 0.7 -0.7 -0.9 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 3.1 0.0 -1.7 -0.9 -1.8 -1.5 -0.1 -1.7 -1.0 -1.2 -1.3
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.7 0.0 0.4 0.3 0.3 -0.3 -0.5 -0.9 -0.1 -0.6 -0.2
Qualifications: CSEs or equivalent 0.4 0.5 1.7 0.0 -0.5 -1.0 -0.8 -0.8 -1.3 0.2 -0.6 -0.8 -0.4
Serious illness, injury or assault to yourself 0.3 0.4 0.8 0.0 0.4 0.6 0.3 -0.5 -0.9 -0.6 0.2 -0.9 -0.9
High blood pressure 0.4 1.2 7.0 0.0 1.1 0.3 1.2 0.7 0.7 2.6 -0.8 -0.5 -0.6
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.7 0.0 -0.2 -0.4 0.1 0.3 0.9 -0.7 0.3 1.6 1.3
Multivitamins +/- minerals 1.6 2.0 5.4 0.0 -2.3 -1.0 -1.7 1.3 2.0 -1.1 1.5 1.0 0.8
Stomach or abdominal pain in last month 0.2 0.3 0.9 0.0 0.4 0.7 0.4 0.8 0.5 0.9 -0.1 0.5 0.3
Supplements: Glucosamine 1.3 1.8 5.3 0.0 -1.6 0.2 -0.1 0.2 2.1 -2.3 -0.0 1.8 1.4
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 4.6 0.0 0.4 2.2 1.7 1.0 1.9 -0.4 1.8 1.1 1.4
Medication: Atenolol 1.8 2.3 10.0 0.0 3.2 1.8 1.9 -0.7 -0.2 1.9 -0.6 -0.9 -1.0
Medication: Levothyroxine sodium 0.1 0.1 0.7 0.0 0.1 0.3 -0.2 -0.2 -0.2 -0.8 -0.1 -0.1 0.0
Sitting height 0.3 2.2 12.0 0.0 -0.2 0.7 0.1 1.9 3.5 0.8 0.7 1.6 1.5
Chronic bronchitis/emphysema (father) 0.9 1.1 3.2 0.0 1.8 1.5 0.9 -0.8 -0.5 1.7 -0.1 -0.5 -0.4
High blood pressure (mother) 1.6 2.2 7.3 0.0 -2.5 -2.7 -2.1 1.6 -0.3 -1.0 0.7 0.4 0.5
Body mass index (BMI) 0.2 0.9 3.7 0.0 -0.3 -0.8 -0.7 0.3 -1.9 -0.0 -1.0 -1.3 -1.4
Impedance of leg (left) 0.7 3.5 9.0 0.0 1.4 3.0 2.4 0.5 2.9 1.2 1.2 1.7 1.9
Leg predicted mass (left) 0.2 0.9 3.1 0.0 -0.9 -1.8 -1.7 0.8 -0.3 -0.5 -0.9 -0.4 -0.6
Trunk fat mass 0.1 0.4 0.9 0.0 0.3 0.3 0.2 0.6 -0.7 0.1 -0.9 -0.9 -0.9
Waist circumference 0.2 0.8 2.8 0.0 -0.9 -1.7 -1.6 0.9 -0.5 -0.7 -0.4 -0.6 -0.6
Number of incorrect matches in round 0.2 0.3 0.8 0.0 0.2 -0.3 -0.6 0.1 -0.9 -0.3 0.5 -0.8 -0.7
Past tobacco smoking 0.4 0.7 2.4 0.0 -0.5 -1.5 -1.0 -0.3 0.4 -1.4 0.8 -0.2 0.2
Alcohol usually taken with meals 0.6 1.0 3.2 0.0 -1.1 -1.8 -1.5 0.0 0.2 -1.4 -0.9 0.4 0.5
Nervous feelings 0.6 1.2 4.5 0.0 0.7 2.1 1.5 -1.2 -1.0 -1.2 0.5 -0.7 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.0 0.0 -0.6 -0.5 -0.3 0.4 0.6 0.3 1.4 1.1 1.3
Hearing difficulty/problems with background noise 0.3 0.5 1.7 0.0 -1.3 -0.2 -0.3 1.1 0.9 -0.5 -0.4 0.6 0.4
Hair/balding pattern: Pattern 2 2.7 3.4 7.8 0.0 -1.3 -0.3 -0.3 2.0 2.6 0.1 2.4 2.8 2.8
Had menopause 0.1 0.1 0.4 0.0 0.5 -0.2 0.2 -0.3 -0.6 -0.2 0.6 -0.5 -0.4
Had other major operations 0.5 0.6 2.4 0.0 0.3 -1.3 -1.6 0.7 0.2 0.8 0.7 0.6 0.5
Forced vital capacity (FVC) 0.6 2.3 11.7 0.0 -1.1 0.0 -0.9 0.0 3.4 -0.7 0.1 2.2 1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.6 0.0 -0.0 -0.7 -0.8 -1.3 0.7 0.4 -0.8 -1.1 -1.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 4.0 0.0 -0.4 0.8 -0.2 -1.2 -0.0 -2.0 -0.0 -0.1 0.0
Qualifications: None of the above 1.0 2.0 3.6 0.0 1.4 1.8 1.3 -0.6 -1.7 1.8 0.2 -1.9 -1.7
Financial difficulties in last 2 years 0.4 0.5 2.3 0.0 0.0 -0.6 0.4 0.3 -0.4 1.4 1.5 -0.1 0.1
Mouth/teeth dental problems 0.2 0.3 0.9 0.0 -0.6 -0.6 0.1 0.3 -0.9 0.3 -0.4 -0.4 -0.9
Heart attack 0.3 0.4 1.3 0.0 1.1 0.2 0.5 -0.9 0.4 0.1 -0.9 0.9 0.4
Allergy 0.3 0.6 3.8 0.0 0.8 0.3 0.8 0.5 0.0 1.9 0.7 -0.6 -0.3
Pain all over the body in last month 0.7 0.8 3.6 0.0 0.1 1.3 0.7 1.9 -0.6 0.3 1.1 0.3 0.6
Diabetes (self-reported) 1.1 1.7 5.6 0.0 2.4 1.1 1.4 -0.7 -1.1 0.7 -1.1 -1.4 -1.5
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.3 0.0 0.7 0.9 1.2 0.2 0.7 -0.1 0.2 1.5 1.5
Medication: Ramipril 0.2 0.2 0.8 0.0 -0.2 0.3 -0.1 -0.4 -0.0 -0.3 -0.9 -0.5 -0.8
Medication: Simvastatin 0.4 0.6 1.9 0.0 1.1 1.3 1.0 0.3 -0.5 -0.4 -1.4 0.1 -0.1
Fluid intelligence score 1.0 2.0 5.2 0.0 -0.9 0.4 0.3 1.5 1.9 -0.8 1.6 2.3 2.1
Illnesses of siblings 0.5 0.6 1.8 0.0 -0.2 -1.3 -1.4 0.2 0.4 0.9 0.4 0.9 1.0
Neuroticism score 0.3 0.7 1.8 0.0 -1.1 0.4 -0.2 -0.3 -1.1 -1.4 0.9 0.6 1.1
Weight 0.1 0.5 1.3 0.0 -0.5 -1.1 -1.1 1.0 -0.4 0.4 -0.7 -0.5 -0.7
Impedance of arm (right) 0.2 1.1 3.4 0.0 1.9 1.4 1.6 -1.1 0.2 -0.8 -0.2 -0.6 -0.4
Arm fat percentage (right) 0.3 1.1 3.9 0.0 0.3 0.1 0.3 0.2 -2.0 -0.4 -1.4 -1.5 -1.5
Trunk fat-free mass 0.3 1.9 5.7 0.0 -1.4 -1.5 -1.4 2.4 1.7 0.8 -0.1 1.5 1.2
Hip circumference 0.1 0.5 1.5 0.0 0.1 -1.2 -0.9 1.1 -0.3 0.7 -0.8 -0.4 -0.7
Time employed in main current job 0.1 0.1 0.6 0.0 0.3 0.3 -0.1 0.2 -0.8 -0.0 0.5 -0.1 0.0
Alcohol intake versus 10 years previously 1.5 2.3 6.4 0.0 2.5 1.1 1.5 0.4 -1.5 2.4 -0.4 -1.5 -1.6
Father’s age at death 0.3 0.4 1.5 0.0 -0.6 -0.1 -0.2 1.2 0.6 0.6 0.7 0.6 0.6
Worrier / anxious feelings 0.5 0.9 3.8 0.0 -0.6 1.9 1.2 -0.2 -0.2 -1.1 0.5 0.8 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 2.9 0.0 -0.4 0.3 -0.6 1.6 0.4 0.0 1.7 0.4 1.0
Falls in the last year 0.9 1.2 3.9 0.0 -0.4 -0.2 -0.2 1.4 1.7 0.1 2.0 1.1 1.4
Hair/balding pattern: Pattern 3 0.5 0.7 2.2 0.0 0.7 0.2 1.2 -1.5 -0.8 -0.4 -0.8 -1.1 -0.7
Number of live births 0.6 0.8 2.1 0.0 0.8 1.4 1.4 0.1 1.0 -0.3 0.6 1.1 1.1
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 5.3 0.0 -1.9 -0.7 -1.3 0.1 2.3 -0.8 0.7 1.6 1.5
Pulse rate 0.4 0.7 1.8 0.0 -1.2 -1.1 -0.8 -0.2 -0.0 -0.0 0.3 -1.3 -1.3
Happiness 0.5 0.6 2.0 0.0 1.4 1.1 0.7 -0.1 -0.0 1.3 0.5 0.6 0.3
Noisy workplace 0.2 0.2 0.8 0.0 -0.2 -0.4 -0.7 0.2 -0.6 0.9 -0.4 -0.3 -0.1
Qualifications: A levels/AS levels or equivalent 1.2 2.6 7.1 0.0 -1.7 -0.2 0.1 0.7 2.7 -1.2 1.0 2.6 2.5
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.0 0.0 -0.2 -0.6 -0.4 0.4 -0.6 -1.0 -0.8 -0.1 -0.4
Mouth/teeth dental problems: Dentures 0.6 1.0 3.5 0.0 1.3 1.9 1.0 -1.1 -0.2 -0.8 -1.2 -0.1 -0.3
Asthma 0.4 0.7 4.4 0.0 -0.9 0.9 -0.4 -0.4 -0.3 -2.1 -0.2 -0.6 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.6 0.0 -1.0 0.0 -0.4 -0.0 0.2 -1.2 1.3 0.5 1.1
Medication: Cholesterol lowering 0.6 0.9 3.1 0.0 -0.4 -0.8 -0.8 -0.4 -1.0 -1.8 -1.1 -0.9 -1.0
Depression (self-reported) 0.3 0.4 1.1 0.0 -0.8 -0.4 -1.0 -0.4 0.6 -0.8 -0.2 -0.6 -0.5
Medication: Lansoprazole 1.3 1.5 3.6 0.0 1.7 1.3 1.9 -1.6 -0.7 1.0 -0.9 -0.8 -1.0
Prospective memory result 0.2 0.3 1.2 0.0 0.2 -0.4 0.3 0.4 -0.0 0.9 0.2 1.1 0.6
Lung cancer (father) 0.7 0.9 2.5 0.0 -0.4 -0.5 -0.8 0.7 1.6 1.2 0.2 1.3 1.3
Illnesses of mother 2.2 2.7 6.3 0.0 1.3 1.2 0.9 -2.5 -1.9 0.9 -1.4 -2.4 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 3.9 0.0 -1.8 -1.0 -1.6 -0.1 2.0 -0.2 0.7 1.4 1.3
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 0.0 -0.6 0.1 0.5 0.6 0.6 -0.6 0.0 -0.6 -0.6
Impedance of arm (left) 0.2 0.9 2.4 0.0 1.1 1.0 1.0 -1.5 -0.1 -1.0 -0.4 -1.0 -0.9
Arm fat mass (right) 0.2 0.7 1.8 0.0 -0.0 -0.2 -0.2 0.6 -1.3 -0.1 -1.3 -1.1 -1.2
Trunk predicted mass 0.4 2.0 6.1 0.0 -1.6 -1.5 -1.5 2.5 1.7 0.8 -0.1 1.5 1.1
Standing height 0.2 2.0 11.2 0.0 -0.2 -0.7 -0.6 1.6 3.3 1.1 0.6 1.4 1.3
Length of working week for main job 1.1 1.2 4.1 0.0 -1.3 -1.8 -2.0 1.0 0.7 -0.6 -1.0 0.3 0.2
Exposure to tobacco smoke at home 0.5 0.6 1.6 0.0 0.8 1.3 1.2 0.3 0.6 -0.4 0.7 0.7 0.6
Breastfed as a baby 0.9 1.2 2.8 0.0 0.5 1.7 1.6 -1.5 -0.8 -1.0 -0.9 -0.9 -1.1
Tense / ‘highly strung’ 1.1 1.9 5.8 0.0 -1.1 1.3 0.2 1.1 0.6 -1.2 1.1 2.4 2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.1 0.0 -0.3 1.0 0.9 0.4 0.3 -0.1 0.4 0.3 0.4
Hair/balding pattern: Pattern 4 0.3 0.8 3.8 0.0 1.2 0.8 0.2 -0.7 -0.7 0.1 -1.9 -0.5 -0.7
Birth weight of first child 0.8 1.4 4.9 0.0 -1.8 -1.1 -1.9 -0.8 0.2 -2.2 -0.1 0.3 0.2
Peak expiratory flow (PEF) 1.0 2.4 7.9 0.0 -1.3 -0.2 -0.7 0.1 2.8 -0.2 1.6 2.4 2.4
Pulse wave reflection index 1.0 1.2 3.8 0.0 0.5 1.1 1.2 1.2 1.9 0.3 0.9 1.4 1.2
Ever highly irritable/argumentative for 2 days 2.7 3.2 6.1 0.0 2.1 1.1 1.2 2.2 2.5 1.4 2.1 1.8 2.2
Loud music exposure frequency 0.4 0.4 2.1 0.0 -0.6 -1.4 -0.6 0.2 0.7 0.6 -0.2 0.6 0.4
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 1.9 0.0 -1.1 -0.6 -0.7 1.2 1.2 -1.0 1.2 1.4 1.2
Mouth/teeth dental problems: Bleeding gums 1.0 1.2 5.4 0.0 0.2 -0.1 0.1 0.5 1.1 0.3 1.8 1.5 2.3
Blood clot in the leg (DVT) 1.6 2.1 14.2 0.0 0.1 -1.2 -1.6 -0.9 -1.0 -3.8 -0.9 -0.5 -0.2
Medication: Paracetamol 0.9 1.5 5.9 0.0 1.2 2.2 2.4 0.6 0.8 1.1 -0.0 0.1 -0.1
Headache pain in last month 0.1 0.1 0.4 0.0 -0.2 0.4 0.2 -0.2 -0.6 -0.5 0.6 -0.1 0.0
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.0 0.0 0.3 0.9 0.5 -0.8 -0.3 0.2 1.4 0.7 0.9
Glaucoma (self-reported) 0.3 0.4 1.5 0.0 1.2 0.7 0.6 -0.0 0.2 1.2 0.3 0.2 0.3
Gout (self-reported) 2.0 2.7 6.7 0.0 -0.3 -2.6 -2.2 -1.7 -0.4 1.9 -1.0 -2.1 -1.9
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 2.7 0.0 -0.4 0.0 -0.4 0.3 -0.7 -1.6 0.0 0.0 -0.0
Medication: Amlodipine 0.2 0.3 1.6 0.0 0.3 -0.2 0.5 1.3 0.1 0.6 0.5 -0.2 0.0
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.8 0.0 -1.3 0.2 -0.6 -1.4 -0.8 -1.2 -0.8 -0.3 -0.3
Birth weight 0.8 1.8 8.3 0.0 -2.1 -2.9 -2.1 0.4 0.2 -0.3 -0.5 -0.1 -0.5
Chronic bronchitis/emphysema (mother) 2.6 3.0 7.4 0.0 -1.1 0.0 -0.8 1.9 2.6 -0.8 1.9 2.7 2.6
High blood pressure (siblings) 0.3 0.4 0.8 0.0 0.1 0.5 0.8 0.8 -0.2 0.8 0.9 -0.9 -0.7
Forced vital capacity (FVC), Best measure 0.4 1.6 8.8 0.0 -0.8 -0.4 -1.3 0.1 3.0 0.1 0.2 1.8 1.4
Body fat percentage 0.2 0.8 1.8 0.0 0.7 0.8 0.7 0.2 -1.2 0.3 -1.1 -1.3 -1.3
Leg fat percentage (right) 0.2 0.7 1.4 0.0 0.4 1.2 0.8 0.6 -1.0 0.7 -1.0 -1.0 -1.1
Arm fat-free mass (right) 0.3 1.4 3.7 0.0 -1.5 -1.2 -1.5 1.9 1.3 0.8 0.2 1.0 0.9
Exposure to tobacco smoke outside home 0.6 0.8 2.4 0.0 -1.0 0.3 -0.1 0.8 1.6 -1.4 1.0 0.9 0.7
Comparative body size at age 10 1.2 3.3 7.0 0.0 -1.5 -2.6 -1.7 -1.8 -2.6 0.6 -1.8 -1.7 -2.1
Number of full brothers 0.6 0.7 3.8 0.0 -0.2 -0.5 -0.4 -0.4 -1.9 -0.2 -1.4 -0.6 -0.7
Worry too long after embarrassment 0.5 0.9 2.9 0.0 -1.3 0.9 0.5 -0.2 -0.6 -1.1 1.7 0.8 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.4 0.0 -1.1 0.5 -0.1 0.8 0.1 -1.5 0.4 0.2 0.4
Wheeze or whistling in the chest in last year 0.2 0.4 1.8 0.0 -1.1 -0.1 -1.0 -0.3 -0.0 -1.3 0.3 -0.4 -0.3
Number of children fathered 0.7 0.8 2.8 0.0 -0.8 -0.7 -0.7 0.2 -1.7 1.5 -0.1 -0.9 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 7.7 0.0 0.2 0.4 1.5 1.4 0.4 0.9 2.8 -0.4 0.4
Age at first live birth 0.0 0.1 0.3 0.0 0.0 -0.1 -0.5 0.6 -0.3 0.3 0.3 -0.1 -0.2
Pulse wave peak to peak time 0.2 0.3 0.8 0.0 0.5 -0.3 -0.7 -0.4 -0.3 0.5 0.2 0.8 0.9
Health satisfaction 0.4 0.6 1.9 0.0 0.3 0.9 -0.2 0.8 0.2 -0.8 0.3 1.4 1.2
Shortness of breath walking on level ground 0.7 0.8 3.2 0.0 0.1 0.2 -0.6 -0.3 -1.1 -1.1 0.4 -1.8 -1.3
Qualifications: College or University degree 0.8 2.4 6.3 0.0 -2.5 -0.6 -0.5 2.0 1.6 -2.2 1.2 1.5 1.6
Eye problems/disorders: None of the above 0.8 1.0 2.3 0.0 -1.2 -1.5 -1.3 0.2 -1.4 -1.4 0.5 -0.3 -0.1
Mouth/teeth dental problems: Loose teeth 0.9 1.0 4.3 0.0 0.9 2.1 1.5 0.6 0.3 0.2 -0.9 1.2 0.5
Emphysema/chronic bronchitis 0.3 0.4 1.2 0.0 0.5 1.1 0.9 -0.4 0.2 0.4 0.6 0.4 0.5
Medication for pain relief, constipation, heartburn 0.3 0.4 2.5 0.0 -0.4 -1.6 -1.2 0.1 0.2 0.1 0.4 0.2 0.4
Neck or shoulder pain in last month 0.4 0.6 3.1 0.0 0.8 1.8 0.7 -0.9 0.0 -0.3 -0.3 0.4 0.5
Medication: Blood pressure 0.3 0.6 1.3 0.0 0.1 -0.7 0.1 0.5 0.9 0.8 -1.0 -0.9 -1.2
Angina (self-reported) 0.1 0.1 0.3 0.0 -0.0 0.4 -0.1 -0.4 0.6 -0.3 0.1 -0.1 -0.0
Migraine (self-reported) 1.5 1.8 4.1 0.0 2.0 1.9 1.6 0.9 1.5 0.5 1.9 0.5 0.9
Medication: Ibuprofen 0.6 0.8 2.9 0.0 -1.2 0.1 -0.5 -0.5 -0.2 -1.7 1.4 0.2 0.8
Medication: Allopurinol 1.6 2.1 4.9 0.0 -0.2 -1.4 -1.7 -1.7 -0.7 1.8 -0.7 -2.2 -2.0
Medication: Omeprazole 0.8 1.0 3.3 0.0 0.8 0.3 0.1 1.4 0.0 1.8 1.6 0.9 0.9
Medication: Seretide 50 evohaler 1.3 1.5 9.4 0.0 -3.1 0.0 -1.4 0.1 -0.0 -1.9 0.2 0.3 0.4
Mean time to correctly identify matches 0.4 0.7 2.8 0.0 0.9 0.2 0.6 -0.1 -1.1 0.1 -1.7 -0.8 -1.0
Heart disease (mother) 0.4 0.5 2.5 0.0 0.2 0.7 0.6 -0.1 -0.9 -1.6 -0.6 -0.3 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 5.8 0.0 0.9 -1.1 -0.0 0.7 -0.2 2.4 1.2 -0.9 -0.4
Whole body fat mass 0.1 0.4 1.2 0.0 0.0 -0.1 -0.2 0.6 -0.8 0.2 -1.1 -1.0 -1.1
Leg fat mass (right) 0.1 0.4 1.0 0.0 -0.1 0.2 -0.1 0.7 -0.9 0.4 -1.0 -0.9 -1.0
Arm predicted mass (right) 0.2 1.1 2.9 0.0 -1.2 -1.2 -1.3 1.7 1.2 1.0 0.1 0.8 0.7
Pulse rate, automated reading 0.1 0.5 0.9 0.0 -0.6 -0.6 -0.6 0.8 1.0 0.4 0.0 -1.0 -0.9
Alcohol intake frequency. 0.2 0.4 1.2 0.0 -0.4 -0.8 -1.1 0.9 -0.0 0.3 0.4 0.4 0.8
Comparative height size at age 10 0.6 3.4 18.2 0.0 0.0 0.1 -0.4 1.9 4.3 0.4 1.4 2.2 2.3
Number of full sisters 0.4 0.5 2.9 0.0 1.7 0.7 0.8 -1.0 0.3 0.0 0.4 0.1 0.1
Suffer from ‘nerves’ 0.7 1.1 3.5 0.0 -0.6 1.0 0.3 -1.7 -1.9 -1.7 0.3 -0.6 -0.2
Overall health rating 0.4 0.8 2.7 0.0 0.4 -0.2 -1.0 -0.2 -1.6 -0.2 -1.3 -1.0 -1.0
Chest pain or discomfort 0.4 0.6 3.6 0.0 0.4 -0.6 -0.8 0.1 -0.1 1.9 -0.4 -0.8 -0.9
Had major operations 0.7 0.8 3.4 0.0 -0.5 -1.8 -1.0 -0.1 1.5 0.5 -0.2 -0.4 -0.6
Age at last live birth 0.4 0.5 1.4 0.0 -0.7 1.2 -0.1 1.2 0.3 -1.1 0.4 0.6 0.4
Family relationship satisfaction 0.3 0.4 1.0 0.0 1.0 -0.7 -1.0 -0.4 -0.1 0.2 -0.9 0.4 -0.1
Leg pain on walking 0.3 0.4 1.0 0.0 -0.2 0.9 0.7 0.6 0.0 1.0 0.6 0.5 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.3 0.0 1.5 0.3 1.0 -0.8 0.2 0.2 0.0 -0.5 -0.5
Commuting to job workplace: Car/motor vehicle 0.3 0.4 2.1 0.0 0.5 0.9 1.4 -0.5 -0.4 0.0 -0.0 0.1 -0.2
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.5 0.0 -0.1 -0.0 -0.7 -0.4 0.5 -0.2 -0.3 0.1 0.1
Medication: Aspirin 0.2 0.3 2.0 0.0 -0.2 0.5 -0.1 -0.2 0.1 -1.4 -0.9 0.3 0.1
Supplements: Vitamin C 0.8 1.0 2.6 0.0 0.6 1.5 1.6 0.9 1.1 0.3 -0.3 1.1 1.0
Knee pain experienced in last month 0.3 0.4 1.4 0.0 0.5 -0.5 -0.7 -1.1 -1.2 -0.0 -0.6 -0.2 -0.5
Hypertension (Self-reported) 0.4 1.0 5.9 0.0 1.1 0.5 1.2 0.6 0.7 2.4 -0.6 -0.4 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.8 0.0 0.5 0.3 0.3 -1.3 0.2 0.3 -0.3 -0.6 -0.7
Illnesses of father: Heart disease 0.3 0.4 1.1 0.0 -0.3 -0.8 -0.4 0.8 1.1 -1.0 0.1 0.2 -0.0
Illnesses of siblings: Diabetes 0.2 0.2 0.8 0.0 -0.6 0.1 0.3 -0.4 -0.6 -0.1 0.2 -0.9 -0.7
Smoking status: Previous 0.3 0.4 2.9 0.0 0.4 0.6 0.5 0.5 -0.6 1.7 0.1 0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.5 0.0 0.6 -0.2 0.1 0.1 0.6 0.5 0.4 0.7 0.5
Whole body fat-free mass 0.2 1.2 3.6 0.0 -1.2 -1.6 -1.5 1.9 1.0 0.4 -0.3 0.8 0.5
Leg fat-free mass (right) 0.2 1.0 3.7 0.0 -0.7 -1.9 -1.7 0.4 -0.5 -0.3 -0.9 -0.8 -0.9
Arm fat percentage (left) 0.3 1.1 3.6 0.0 0.2 0.1 0.1 0.1 -1.9 -0.4 -1.4 -1.6 -1.6
Average weekly red wine intake 0.2 0.3 1.1 0.0 -0.1 -0.3 0.3 0.4 0.9 -0.4 0.4 0.9 1.0
Handedness (chirality/laterality): Left-handed 1.0 1.2 3.5 0.0 -0.1 -1.5 -0.8 0.8 0.9 -0.7 0.8 1.6 1.9
Mood swings 0.3 0.5 1.3 0.0 -1.1 -0.0 -0.8 -0.6 -1.1 -0.5 1.1 -0.2 0.2
Loneliness, isolation 0.5 0.6 2.0 0.0 -0.0 -1.4 -1.0 0.7 0.7 0.6 0.7 0.8 0.9
Long-standing illness, disability or infirmity 0.2 0.3 0.9 0.0 0.4 1.0 -0.1 0.7 -0.1 -0.7 -0.8 -0.1 -0.5
Ever had bowel cancer screening 0.6 0.7 3.2 0.0 0.8 -0.4 -0.4 -0.4 -1.6 1.8 0.1 -0.2 -0.1
Diabetes diagnosed by doctor 1.3 2.1 8.2 0.0 2.9 1.6 1.8 -0.4 -1.0 1.0 -0.7 -1.5 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.5 0.0 1.6 1.0 1.1 0.1 0.8 1.2 -0.4 -0.8 -1.0
Friendships satisfaction 0.8 1.0 4.8 0.0 -0.1 0.1 -0.1 0.3 0.8 0.5 1.1 2.2 1.9
Qualifications: nursing, teaching 2.8 4.3 7.9 0.0 -2.4 -2.3 -1.7 2.8 2.6 -0.8 1.6 2.6 2.2
Commuting to job workplace: Walk 0.6 0.7 2.6 0.0 0.4 -0.1 -0.6 0.9 0.3 1.4 1.6 0.3 0.7
Eye problems/disorders: Cataract 0.5 0.6 1.5 0.0 0.5 1.1 0.9 -1.2 -0.5 -0.3 -1.1 -0.6 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 6.0 0.0 -1.2 -2.3 -2.4 -0.6 0.1 0.4 0.2 0.2 0.5
Medication for cholesterol 1.5 2.3 7.4 0.0 -2.6 -2.7 -2.1 -1.2 -0.1 -1.5 -0.5 -0.3 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.2 2.6 9.4 0.0 -0.6 -0.5 -0.6 -0.1 -2.2 1.2 -0.8 -3.1 -2.9
Back pain experienced in last month 0.7 1.0 3.6 0.0 1.9 0.9 0.4 0.9 0.5 1.7 0.4 0.9 0.6
Mineral and other dietary supplements 1.0 1.4 4.3 0.0 1.0 -1.3 -0.7 -0.2 -2.1 1.9 -0.1 -1.3 -0.9
Breast cancer (self-reported) 0.7 0.9 2.9 0.0 -0.2 -1.7 -1.2 -1.3 -1.1 -1.0 -0.3 -0.2 -0.4
Asthma (self-reported) 0.3 0.7 4.8 0.0 -1.0 1.0 -0.4 -0.2 0.0 -2.2 -0.2 -0.1 0.0
Osteoporosis (self-reported) 0.7 0.9 2.7 0.0 0.8 1.1 1.6 1.1 0.4 0.2 1.2 0.6 1.0
Osteoarthritis (self-reported) 1.0 1.3 4.1 0.0 1.6 1.8 1.7 0.1 0.1 -0.1 -2.0 0.3 -0.1
Medication: Aspirin 0.2 0.3 1.4 0.0 -0.3 0.2 -0.4 -0.6 -0.4 -1.2 -0.8 -0.3 -0.5
Medication: Gliclazide 0.4 0.5 1.3 0.0 0.9 0.3 0.4 -0.4 -1.1 -0.4 -0.9 -0.8 -0.8
Illnesses of father: None of the above (group 1) 0.2 0.3 0.8 0.0 -0.8 -0.9 -0.8 -0.2 -0.2 -0.2 -0.2 0.6 0.7
Smoking status: Current 1.5 2.3 5.3 0.0 2.0 2.3 2.2 0.6 2.0 1.1 -1.0 1.4 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 7.9 0.0 -2.8 -2.4 -2.6 -2.1 -1.2 -0.9 -0.3 -1.8 -1.8
Whole body water mass 0.2 1.2 3.7 0.0 -1.3 -1.6 -1.5 1.9 1.0 0.3 -0.2 0.8 0.6
Leg predicted mass (right) 0.2 0.9 3.6 0.0 -0.7 -1.9 -1.7 0.5 -0.4 -0.3 -0.8 -0.7 -0.8
Arm fat mass (left) 0.1 0.5 1.6 0.0 -0.2 -0.4 -0.4 0.8 -0.9 -0.1 -1.3 -0.8 -1.0
Number of self-reported non-cancer illnesses 0.3 0.4 1.3 0.0 1.0 -0.2 0.2 0.0 -1.1 1.1 -0.4 -0.6 -0.5
Average weekly champagne plus white wine intake 0.9 1.2 5.2 0.0 -0.8 -0.2 -0.1 1.1 0.7 -0.3 2.3 1.2 1.8
Miserableness 0.5 1.0 2.8 0.0 -1.7 -0.6 -1.4 0.5 -0.4 -1.4 0.6 0.8 1.1
Guilty feelings 0.2 0.3 1.1 0.0 -0.5 0.5 0.4 -1.0 -0.7 -1.1 0.1 -0.2 -0.0
Wears glasses or contact lenses 0.3 0.4 2.2 0.0 -0.2 0.0 -0.3 -0.3 -1.0 -1.5 -0.0 0.2 -0.0
Ever taken oral contraceptive pill 0.2 0.2 0.5 0.0 -0.4 0.4 0.7 0.7 -0.3 0.6 0.0 0.0 -0.3
Hearing aid user 1.3 1.5 3.0 0.0 0.2 1.1 0.9 1.5 1.7 0.6 1.1 1.7 1.7
Mother’s age at death 0.7 0.8 3.6 0.0 -1.9 -1.0 -1.3 1.2 0.2 0.4 0.1 -0.3 -0.2
Financial situation satisfaction 0.6 0.8 1.8 0.0 1.3 1.1 0.5 0.2 0.5 1.4 1.1 0.8 0.9
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.2 0.0 0.3 0.9 1.1 -0.1 0.5 0.0 1.0 -0.1 0.2
Commuting to job workplace: Public transport 0.5 0.6 1.1 0.0 -1.0 -0.9 -0.9 0.9 0.9 -0.5 1.0 0.2 0.6
Eye problems/disorders: Glaucoma 0.6 0.7 2.7 0.0 1.2 1.6 1.0 -0.1 0.9 0.0 0.9 0.2 0.3
Medication: Blood pressure 1.1 2.2 6.5 0.0 2.5 1.8 1.9 1.2 1.0 2.1 0.1 0.9 0.7
Pain type(s) experienced in last month: Hip pain 1.8 2.3 7.0 0.0 2.6 2.1 2.6 0.1 0.1 1.7 1.1 0.5 0.5
Supplements: Fish oil (including cod liver oil) 0.9 1.2 4.6 0.0 0.2 1.6 1.5 0.6 2.1 -1.0 -0.8 0.8 0.3
High cholesterol (Self-reported) 0.4 0.7 2.7 0.0 0.6 -0.2 0.4 0.5 -1.7 -1.1 -1.4 -0.5 -0.8
Medication: Bendroflumethiazide 0.9 1.4 4.1 0.0 0.8 -0.3 0.2 2.0 1.4 1.7 0.1 1.6 1.3
Medication: Paracetamol 1.0 1.6 6.9 0.0 1.6 2.0 2.6 0.5 0.4 1.4 0.3 -0.3 -0.5
Medication: Lisinopril 0.3 0.4 1.6 0.0 -0.0 -0.1 0.3 0.2 -0.2 0.6 -1.3 -0.9 -1.0
Medication: Atorvastatin 1.3 1.6 6.0 0.0 1.4 0.5 0.3 -0.9 -1.3 -2.5 -0.9 -1.3 -1.5
Illnesses of father: High blood pressure 0.2 0.3 1.0 0.0 -1.0 -0.1 -0.6 0.3 -0.1 -0.4 -0.0 -0.7 -0.7
Alcohol drinker status: Never 2.8 3.4 11.4 0.0 -0.5 1.4 0.1 1.0 2.3 -1.8 3.4 1.9 2.6
Ever smoked 1.2 2.2 6.8 0.0 0.1 -0.2 -0.0 -1.1 -1.9 1.9 -2.6 -1.4 -2.1
Basal metabolic rate 0.2 1.0 2.8 0.0 -1.1 -1.6 -1.5 1.7 0.6 0.3 -0.6 0.5 0.2
Leg fat percentage (left) 0.2 0.7 1.0 0.0 0.6 1.0 0.8 0.4 -1.0 0.8 -1.0 -1.0 -1.0
Arm fat-free mass (left) 0.2 1.2 3.9 0.0 -1.1 -1.2 -1.2 2.0 1.3 0.8 -0.2 0.9 0.7
Number of operations (self-reported) 0.5 0.8 3.8 0.0 -0.0 -1.9 -1.8 -0.3 0.2 0.4 0.4 0.6 0.3
Average weekly beer plus cider intake 0.2 0.3 1.4 0.0 0.3 1.1 0.5 -0.3 -0.1 0.4 1.2 -0.5 -0.2
Irritability 0.2 0.3 1.3 0.0 0.7 1.2 1.0 -0.1 -0.3 0.1 0.3 0.2 0.2
Risk taking 0.4 0.6 2.6 0.0 0.7 -0.2 0.1 1.1 1.1 1.6 0.1 -0.3 -0.5
Ever had prostate specific antigen (PSA) test 0.6 0.7 3.0 0.0 0.1 1.0 1.2 0.8 -0.5 1.7 -0.9 0.3 -0.2
Fractured/broken bones in last 5 years 0.1 0.2 0.5 0.0 0.7 0.2 0.5 0.3 0.0 0.7 0.3 -0.5 -0.4
Age started oral contraceptive pill 0.2 0.2 0.6 0.0 0.4 -0.6 0.1 0.1 0.8 0.4 0.6 0.4 0.4
Diastolic blood pressure, automated reading 0.4 1.1 3.1 0.0 0.6 1.2 1.2 1.7 1.8 0.6 0.4 1.1 0.7
Ever depressed for a whole week 0.8 0.9 3.3 0.0 1.1 1.8 1.2 -1.6 -0.9 -0.2 -0.3 -0.1 0.1
Unable to work because of sickness or disability 0.6 0.8 2.1 0.0 -1.3 0.9 -1.0 1.4 -0.6 -1.4 -0.6 -0.2 -0.3
Commuting to job workplace: Cycle 0.6 0.7 1.6 0.0 -1.3 -0.1 -0.3 0.7 0.7 -0.6 -1.2 1.2 0.9
Myopia 1.2 1.7 5.5 0.0 -1.9 -1.4 -2.3 0.9 -1.8 -0.8 0.2 -0.6 -0.6
Vascular/heart problems diagnosed by doctor 0.4 1.0 5.6 0.0 -1.3 -0.4 -1.1 -0.2 -0.6 -2.4 0.6 0.6 0.6
Cholesterol lowering medication 1.0 1.5 6.0 0.0 1.5 2.5 2.0 0.9 -0.9 -1.1 -0.4 0.4 0.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.6 0.0 0.9 0.6 0.1 0.7 -0.3 1.3 0.7 0.2 0.1
Pain experienced in last month 0.3 0.6 2.3 0.0 -1.5 -1.3 -0.3 -0.0 0.8 -0.7 -0.5 0.0 0.1
Supplements: Calcium 0.5 0.6 2.0 0.0 -0.8 -1.4 -1.1 -0.8 -0.1 -0.8 -0.3 -0.1 -0.4
Basal cell carcinoma (self-reported) 0.2 0.2 1.4 0.0 -0.3 0.6 -0.5 0.0 -0.3 -1.2 -0.2 0.4 0.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.3 0.0 1.1 0.1 0.5 -1.2 0.3 0.1 -1.0 0.5 0.1
Deep venous thrombosis (DVT) (self-reported) 1.5 1.9 13.1 0.0 0.1 -1.4 -1.6 -0.8 -0.7 -3.6 -0.7 -0.3 -0.1
Heart disease (siblings) 0.8 1.0 5.6 0.0 1.2 0.5 0.5 -0.9 0.5 -0.8 -2.4 0.1 -0.5
Alcohol drinker status: Previous 0.7 0.8 1.7 0.0 0.7 -0.0 -0.6 -0.2 -1.1 1.1 -1.0 -1.2 -1.3
Pack years of smoking 1.5 2.2 9.2 0.0 0.8 1.6 1.0 0.6 3.0 0.7 -0.7 2.0 1.6
Impedance of whole body 0.3 1.4 4.9 0.0 1.5 2.2 1.9 -0.9 1.4 -0.3 0.6 0.1 0.3
Leg fat mass (left) 0.1 0.4 1.1 0.0 0.0 0.1 -0.1 0.6 -1.0 0.4 -1.0 -0.9 -1.0
Arm predicted mass (left) 0.3 1.3 3.8 0.0 -1.0 -1.4 -1.2 1.9 1.2 1.3 -0.1 0.9 0.8