TWAS hub - DCI

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0570	0.0310	0.00140	0.014	0.033	0.031	NA	0.025	0.02200	0.00078	0.00100	NA	3.1e-03
2	TCGA	Breast Invasive Carcinoma	0.0265	0.0136	0.00027	0.009	0.009	0.016	NA	0.017	0.00410	0.00460	0.00024	NA	1.4e-04
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0454	0.0237	0.00140	0.029	0.027	0.033	NA	0.036	0.00030	0.00044	0.00011	NA	6.5e-05
4	TCGA	Prostate Adenocarcinoma	0.0469	0.0224	0.00076	0.032	0.030	0.031	NA	0.031	0.00026	0.00035	0.00033	NA	3.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	5.0	7.9	11.9	-3.5	-2.4	-2.5	-2.8
Depression (self-reported)	4.5	5.5	8.8	-3.0	-2.0	-2.2	-2.1
Birth weight	4.0	8.6	13.5	3.3	1.3	2.9	3.7
Comparative height size at age 10	4.0	22.0	40.6	2.9	1.4	6.1	6.4
Frequency of depressed mood in last 2 weeks	3.8	5.3	8.5	-2.4	-1.4	-2.2	-2.9
Hair/balding pattern: Pattern 3	3.7	5.5	5.7	-2.4	-2.4	-2.4	-2.3
Number of children fathered	3.7	4.2	8.2	-2.0	-1.4	-2.9	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	3.6	8.1	13.5	-2.8	-1.1	-3.2	-3.7
Heel bone mineral density (BMD) T-score, automated (right)	3.5	8.0	12.6	-2.9	-1.2	-3.1	-3.6
Loud music exposure frequency	3.5	3.8	6.1	-2.5	-1.3	-1.8	-2.1
Heel T-Score	3.4	26.9	43.0	-3.6	-3.2	-6.6	-6.4
Number of incorrect matches in round	3.0	5.0	5.6	2.4	2.1	2.4	2.1
Hearing difficulty/problems with background noise	2.8	4.4	6.5	-1.9	-1.8	-2.1	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	6.0	-2.0	-1.0	-1.9	-2.5
Depression (Nagel 2018)	2.6	3.8	7.6	-2.0	-0.9	-1.7	-2.8
Angina	2.6	3.4	4.7	-1.1	-1.7	-2.1	-2.2
Deep venous thrombosis (DVT) (self-reported)	2.6	3.3	6.5	2.5	1.3	1.5	1.7
Nervous feelings	2.5	4.6	6.2	-2.2	-2.0	-2.5	-1.9
Suffer from ‘nerves’	2.5	3.9	6.1	-2.5	-1.3	-1.6	-2.3
Alcohol usually taken with meals	2.4	3.9	6.9	2.1	1.0	1.8	2.6
Medication: Ramipril	2.3	3.0	4.0	-1.3	-2.0	-1.5	-1.9
Standing height	2.3	22.4	40.6	2.8	0.9	6.3	6.4
Shortness of breath walking on level ground	2.3	2.7	4.1	-2.0	-1.7	-1.5	-1.3
Angina (self-reported)	2.3	3.1	4.9	-1.0	-1.5	-2.0	-2.2
Back pain experienced in last month	2.3	3.4	6.9	-0.7	-1.5	-2.6	-2.0
Cardiovascular Disease	2.2	7.1	11.2	-1.6	-3.3	-2.9	-2.5
Hand grip strength (left)	2.2	5.8	11.6	-0.2	1.8	3.4	2.9
Time employed in main current job	2.2	2.5	4.0	1.1	1.6	1.6	2.0
Asthma	2.2	4.3	12.0	3.5	0.5	0.8	2.1
High blood pressure	2.1	5.9	7.3	-1.9	-2.6	-2.7	-2.4
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.2	3.6	-1.6	-1.9	-1.8	-1.8
Worrier / anxious feelings	2.1	3.9	7.2	-1.6	-2.7	-1.8	-1.5
Number of full sisters	2.1	2.5	4.3	0.7	1.3	1.9	2.1
HbA1C	2.0	2.2	3.4	-1.4	-1.8	-0.8	-1.7
Stomach or abdominal pain in last month	2.0	2.4	4.9	-1.7	-0.2	-1.4	-2.2
Medication: Ventolin 100micrograms inhaler	2.0	2.6	5.1	2.3	1.4	0.9	1.5
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	4.7	-0.7	-2.2	-1.8	-1.2
Knee pain experienced in last month	2.0	3.1	5.0	1.8	1.2	1.6	2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.2	5.4	2.3	2.0	1.8	2.1
Vascular/heart problems diagnosed by doctor	2.0	5.5	6.9	1.8	2.6	2.5	2.3
Age when periods started (menarche)	1.9	4.5	9.7	-3.1	-1.1	-1.4	-2.2
Trunk fat-free mass	1.9	11.0	20.4	1.9	-0.9	4.4	4.5
Trunk predicted mass	1.9	11.0	20.3	1.9	-0.8	4.4	4.5
Supplements: Vitamin C	1.9	2.3	3.8	1.3	0.7	2.0	1.8
Hypertension (Self-reported)	1.9	5.4	6.8	-1.7	-2.6	-2.6	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	3.7	1.1	-1.9	-1.7	-1.1
Asthma (self-reported)	1.9	3.8	10.4	3.2	0.5	0.7	2.0
Financial situation satisfaction	1.9	2.3	4.3	-1.2	-1.0	-1.6	-2.1
Diabetes (mother)	1.8	2.4	3.7	1.7	1.2	1.9	1.1
Medication: Atenolol	1.8	2.2	5.5	-1.4	-2.3	-1.0	-0.6
Blood clot in the leg (DVT)	1.8	2.3	5.0	2.2	1.0	1.3	1.3
Medication: Blood pressure	1.8	3.2	4.8	-2.1	-2.2	-1.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	8.5	1.0	0.2	2.3	2.9
Whole body fat-free mass	1.8	10.1	19.0	1.8	-1.0	4.1	4.4
Whole body water mass	1.8	10.1	19.2	1.8	-1.0	4.1	4.4
Ever taken oral contraceptive pill	1.8	2.0	2.9	-1.6	-1.3	-1.0	-1.7
Pain all over the body in last month	1.7	1.9	3.9	-2.0	-1.1	-0.4	-1.5
Noisy workplace	1.7	2.1	4.5	-2.1	-1.5	-0.8	-1.0
Peak expiratory flow (PEF)	1.7	3.8	5.1	1.3	2.0	2.2	2.1
Health satisfaction	1.7	2.2	3.2	-1.6	-1.1	-1.4	-1.8
Basal metabolic rate	1.7	9.6	18.3	1.8	-0.8	4.0	4.3
Arm predicted mass (left)	1.7	8.9	17.1	1.4	-0.8	4.0	4.1
Waist Hip Ratio (WHR)	1.6	7.4	11.2	2.1	2.5	2.8	3.3
Lung FEV1/FVC ratio	1.6	8.1	11.9	3.4	0.8	3.1	3.2
Arm fat-free mass (right)	1.6	8.1	15.5	1.2	-1.1	3.8	3.9
Eye problems/disorders: Cataract	1.6	1.8	3.0	-1.3	-0.9	-1.3	-1.7
Arm fat-free mass (left)	1.6	8.2	15.6	1.2	-0.8	3.9	4.0
Neuroticism (Nagel 2018)	1.5	3.6	5.7	-1.7	-2.4	-1.6	-1.8
Leg fat-free mass (left)	1.5	7.8	14.8	1.9	-1.1	3.4	3.9
Sitting height	1.5	10.9	25.4	0.0	1.5	5.0	4.0
Leg predicted mass (left)	1.5	7.7	14.9	1.8	-1.1	3.4	3.9
Weight	1.5	7.4	15.4	1.7	-0.4	3.3	3.9
Number of live births	1.5	2.1	7.1	0.2	2.7	1.1	0.1
Eye problems/disorders: None of the above	1.5	1.7	3.7	0.7	1.1	1.9	1.2
Arm predicted mass (right)	1.5	7.9	15.6	1.0	-0.9	3.8	4.0
Medication: Bendroflumethiazide	1.5	2.3	6.0	-0.7	-2.4	-1.4	-0.8
Basal cell carcinoma (self-reported)	1.5	1.7	3.0	1.7	0.6	0.8	1.7
Triglycerides	1.4	2.2	3.6	0.4	-1.6	-1.6	-1.9
Hearing difficulty/problems: Yes	1.4	2.1	3.2	-1.2	-1.4	-1.3	-1.8
Maternal smoking around birth	1.4	2.1	2.9	0.2	-1.6	-1.6	-1.7
Waist circumference	1.4	5.0	10.6	1.8	0.2	2.5	3.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	3.0	0.7	1.3	1.2	1.7
Overall health rating	1.4	2.9	4.6	-1.1	-2.1	-2.2	-1.2
Ulcerative Colitis (UC)	1.3	2.5	5.5	-2.4	0.1	-1.0	-1.8
Respiratory disease	1.3	3.0	9.4	3.1	0.7	0.2	1.4
Ever had hysterectomy (womb removed)	1.3	1.5	2.7	0.7	1.6	1.3	1.1
Qualifications: CSEs or equivalent	1.3	1.7	3.5	0.4	1.9	1.7	0.6
Allergy	1.3	3.0	8.6	-2.9	-0.6	-1.0	-1.5
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.6	1.6	1.4	1.3	0.8
Leg fat-free mass (right)	1.3	7.2	13.9	1.5	-1.1	3.4	3.7
Leg predicted mass (right)	1.3	7.0	13.6	1.5	-1.1	3.3	3.7
Unable to work because of sickness or disability	1.3	1.7	2.8	-1.6	-0.8	-0.8	-1.7
Worry (Nagel 2018)	1.2	2.6	3.6	-1.4	-1.9	-1.6	-1.5
Prostate Cancer	1.2	1.7	3.5	-0.1	-0.8	-1.9	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	6.5	1.7	0.3	2.6	2.5
Alcohol drinker status: Never	1.2	1.5	3.6	-1.1	-1.9	-0.9	-0.5
Ulcerative Colitis	1.1	1.6	3.2	-1.8	0.1	-1.1	-1.4
Systolic Blood Pressure	1.1	5.7	13.7	-3.7	-1.6	-1.5	-2.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	2.0	-1.3	-1.3	-1.4	-1.4
Schizophrenia vs Biploar Disorder	1.0	1.3	2.3	1.5	0.5	1.1	1.2
Mean Putamen Volume	1.0	1.1	3.0	0.3	1.7	0.5	1.0
Height	1.0	20.2	40.1	2.1	-1.0	6.3	5.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.3	1.5	0.9	0.8	0.9
Supplements: Glucosamine	1.0	1.3	1.9	1.1	1.2	0.9	1.4
Trunk fat mass	1.0	4.5	10.4	1.3	0.2	2.4	3.2
Had menopause	1.0	1.3	3.2	-0.7	1.8	1.2	0.3
Mouth/teeth dental problems	1.0	1.5	2.5	0.6	1.0	1.5	1.6
Exposure to tobacco smoke at home	1.0	1.2	3.1	0.4	1.1	1.8	0.4
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.5	0.5	-1.6	-1.3	0.1
Worry too long after embarrassment	1.0	1.7	3.5	-0.9	-0.3	-1.9	-1.6
Medication: Seretide 50 evohaler	1.0	1.2	3.7	1.9	0.7	-0.2	0.7
Commuting to job workplace: Public transport	1.0	1.2	2.9	1.0	-0.8	0.4	1.7
Medication: Lisinopril	1.0	1.3	1.8	-1.1	-1.0	-1.4	-1.1
Pain experienced in last month	1.0	1.7	2.5	1.0	0.9	1.6	1.6
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.0	-1.2	-0.8	-1.2	-1.7
Length of working week for main job	0.9	1.0	2.3	1.1	-0.2	0.6	1.5
Forced vital capacity (FVC), Best measure	0.9	3.4	6.2	1.3	0.7	2.5	2.2
Medication: Allopurinol	0.9	1.1	2.0	0.9	1.4	1.1	0.7
Whole body fat mass	0.9	3.8	8.6	1.3	0.2	2.2	2.9
Osteoporosis (self-reported)	0.9	1.2	3.1	1.1	1.8	0.4	0.5
Average weekly champagne plus white wine intake	0.9	1.2	2.4	1.0	-1.6	0.4	1.1
Guilty feelings	0.9	1.3	3.8	-2.0	-0.3	-0.5	-1.1
Myopia	0.9	1.3	2.7	-0.4	1.6	1.5	0.4
Irritable Bowel Disease (IBD)	0.8	1.8	4.3	-2.1	-0.4	-0.8	-1.5
Breast Cancer	0.8	1.9	6.1	-2.5	-0.2	0.1	-1.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.4	-0.8	0.8	1.5	0.7
Medication: Lansoprazole	0.8	0.9	1.2	-0.9	-0.7	-1.1	-1.0
Prospective memory result	0.8	1.0	1.5	1.1	0.4	1.1	1.2
Arm fat mass (right)	0.8	3.2	6.9	1.7	-0.2	1.7	2.6
Tense / ‘highly strung’	0.8	1.4	2.1	-0.9	-1.0	-1.2	-1.5
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.8	0.7	2.0	0.8	-0.3
Age at first live birth	0.8	1.4	2.3	-1.2	-1.1	-1.5	-0.6
Migraine (self-reported)	0.8	1.0	3.5	-1.9	0.1	-0.2	-0.6
Illnesses of siblings: Diabetes	0.8	1.0	2.2	0.9	1.5	0.9	0.4
Osteoarthritis (self-reported)	0.8	1.1	2.1	1.4	-0.3	0.6	1.3
Wears glasses or contact lenses	0.8	0.9	1.7	1.3	0.5	0.2	1.3
Bipolar Disorder or Schizophrenia	0.7	1.6	3.8	-2.0	-0.8	-1.1	-0.9
Body Mass Index (BMI) (2010)	0.7	1.0	1.8	1.3	0.5	0.6	1.2
LDL Cholesterol	0.7	1.2	4.1	2.0	-0.6	-0.2	0.5
Hand grip strength (right)	0.7	1.9	3.7	-0.8	1.0	1.9	1.5
Relative age voice broke	0.7	1.0	2.3	0.0	1.3	-0.4	-1.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	4.5	1.1	0.7	2.1	1.8
Medication: Paracetamol	0.7	1.1	1.6	1.1	0.1	1.3	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.0	-0.8	-1.4	-0.6	-0.8
Family relationship satisfaction	0.7	0.8	2.2	-0.9	-0.4	-0.4	-1.5
Commuting to job workplace: Walk	0.7	0.7	2.5	0.5	-0.0	1.6	0.5
Illnesses of father: High blood pressure	0.7	0.8	2.2	1.5	0.9	0.5	0.3
Irritability	0.7	1.2	3.9	-0.1	-2.0	-0.7	-0.6
Reaction Time	0.6	1.1	3.0	-0.6	-1.7	-1.1	0.2
Fasting Glucose	0.6	0.7	1.3	-0.7	-0.7	-0.8	-1.1
Medication: Metformin	0.6	0.8	1.5	1.2	1.2	0.7	0.2
Fed-up feelings	0.6	1.0	2.8	-0.5	-1.7	-0.8	-0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.3	-0.9	-1.1	-0.8	-0.0
Chronic bronchitis/emphysema (father)	0.6	0.6	1.9	-0.3	-0.0	-1.4	-0.8
Forced vital capacity (FVC)	0.6	2.2	4.3	0.7	0.8	2.1	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.3	0.9	0.6	0.8	1.2
Lung cancer (father)	0.6	0.7	0.9	0.7	0.7	0.9	1.0
Birth weight of first child	0.6	1.2	1.7	1.3	-0.1	1.3	1.1
Comparative body size at age 10	0.6	1.5	3.2	0.7	0.9	1.8	1.3
Wheeze or whistling in the chest in last year	0.6	1.0	2.6	-0.2	-0.8	-1.6	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	-0.4	-0.6	-1.2	-0.8
Medication for pain relief, constipation, heartburn	0.6	0.9	2.5	-1.0	1.6	0.2	-0.4
Medication: Omeprazole	0.6	0.7	0.9	0.9	-1.0	-1.0	-0.6
Leg fat mass (right)	0.6	2.3	5.5	1.0	-0.2	1.6	2.4
Pulse rate, automated reading	0.6	1.8	4.3	0.2	-2.1	-1.5	-0.7
Age at last live birth	0.6	0.8	1.5	-1.2	-0.7	-0.9	-0.7
Leg pain on walking	0.6	0.7	1.5	-0.7	-1.2	-0.7	-0.5
Smoking status: Previous	0.6	0.9	2.3	-1.0	-0.6	1.5	0.5
Loneliness, isolation	0.6	0.9	1.4	-1.2	-0.6	-1.0	-0.9
Long-standing illness, disability or infirmity	0.6	0.9	2.3	-0.1	-1.5	-0.9	-0.6
Medication: Gliclazide	0.6	0.7	0.9	0.7	1.0	0.8	0.9
Arm fat mass (left)	0.6	2.6	5.8	1.3	-0.2	1.7	2.4
High cholesterol (Self-reported)	0.6	1.0	2.1	1.4	-1.3	-0.4	0.2
Ever smoked	0.6	1.1	3.0	-1.0	-0.2	1.7	0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.1	1.1	-1.0	-1.0	0.0
Depressed Affect (Nagel 2018)	0.5	1.1	2.9	-1.0	-1.7	-0.5	-0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	0.6	1.1	0.9	0.5
Ovarian Cancer	0.5	0.7	1.1	0.7	-1.1	-0.9	-0.4
Blood White Count	0.5	3.8	7.8	0.9	1.1	2.3	2.8
Hypothyroidism (self reported)	0.5	1.1	2.2	1.5	-0.3	1.1	1.0
Average weekly spirits intake	0.5	0.6	2.0	0.6	-1.4	-0.2	-0.3
Trunk fat percentage	0.5	2.1	4.8	0.9	0.7	1.5	2.2
Past tobacco smoking	0.5	0.9	2.4	1.0	0.5	-1.6	-0.2
Hair/balding pattern: Pattern 2	0.5	0.7	1.1	1.0	0.1	0.8	1.1
Heart attack	0.5	0.6	1.1	-0.6	-1.1	-0.4	-0.8
Illnesses of mother	0.5	0.6	1.1	-0.8	0.3	-0.7	-1.1
Breastfed as a baby	0.5	0.6	1.5	0.0	-0.9	-1.2	-0.4
Glaucoma (self-reported)	0.5	0.6	1.8	0.0	-1.3	-0.8	-0.3
Gout (self-reported)	0.5	0.7	1.2	0.3	-1.1	-0.9	-0.8
Exposure to tobacco smoke outside home	0.5	0.7	1.7	0.4	1.3	0.9	-0.3
Medication: Ibuprofen	0.5	0.6	1.1	0.9	-0.3	0.5	1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.0	0.6	1.0	-0.9	-0.2
Medication: Atorvastatin	0.5	0.6	1.7	0.6	1.3	0.4	0.4
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.3	0.4	-1.1	-0.3	0.8
Ever depressed for a whole week	0.5	0.7	2.1	-1.4	-0.6	-0.6	-0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	-0.5	-1.0	-0.5	-1.0
Leg fat mass (left)	0.5	2.1	5.0	0.9	-0.2	1.6	2.2
Alzheimer’s Disease (in father)	0.4	0.4	1.4	0.3	-1.2	-0.5	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.8	-1.1	-1.4	-0.7	-0.6
Age at First Birth	0.4	0.6	1.5	-0.4	1.2	0.7	0.7
Rheumatoid Arthritis	0.4	0.5	1.2	1.1	-0.4	0.7	0.6
Smoking Status	0.4	1.1	2.2	-1.1	-1.5	-0.3	-0.9
Allergy or Eczema	0.4	1.1	2.3	1.5	0.6	0.8	1.0
Number of treatments/medications taken	0.4	0.8	1.6	0.1	-1.3	-1.1	-0.5
Systolic blood pressure, automated reading	0.4	1.0	3.0	-1.7	-0.6	-0.4	-0.8
Vitamin and mineral supplements	0.4	0.6	1.2	-1.1	0.2	-1.1	-0.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	0.4	0.9	0.6	-0.5
Medication: Levothyroxine sodium	0.4	0.6	1.9	1.4	0.4	0.6	0.2
Impedance of leg (left)	0.4	1.9	6.1	-0.9	2.5	0.0	-0.8
Medication: Simvastatin	0.4	0.6	1.5	0.7	-1.2	-0.7	-0.3
Impedance of arm (right)	0.4	1.9	5.3	1.4	2.3	-0.5	-0.4
Hip circumference	0.4	1.9	3.3	0.6	-1.0	1.7	1.8
Pulse rate	0.4	0.6	1.5	-0.1	-1.2	-0.6	-0.7
Medication: Cholesterol lowering	0.4	0.7	1.4	0.7	-1.2	0.1	1.0
Pulse wave Arterial Stiffness index	0.4	0.4	1.6	-0.0	-1.2	0.1	-0.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	-0.4	-0.7	-1.0	-0.5
Body fat percentage	0.4	1.4	3.4	0.8	0.6	1.2	1.8
Pulse wave peak to peak time	0.4	0.5	1.5	0.2	1.2	0.3	0.6
Mean time to correctly identify matches	0.4	0.8	2.6	-0.4	-1.6	-0.6	0.2
Alcohol intake frequency.	0.4	0.8	1.6	-1.0	-0.0	-0.8	-1.3
Mood swings	0.4	0.6	2.1	-0.5	-1.4	-0.4	0.1
Qualifications: nursing, teaching	0.4	0.6	1.2	-0.5	-1.1	-0.8	-0.6
Eye problems/disorders: Glaucoma	0.4	0.5	0.7	-0.6	-0.8	-0.7	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	0.8	0.2	-0.1	1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	0.4	1.1	0.8	0.0
Heart disease (siblings)	0.4	0.4	1.0	-0.7	-1.0	0.4	-0.3
Impedance of whole body	0.4	1.8	5.8	-0.2	2.4	-0.7	-1.1
Schizophrenia (2018)	0.3	0.5	1.1	0.2	0.8	0.6	1.1
Crohns Disease (2012)	0.3	0.5	1.3	-0.1	0.7	1.1	0.4
Lupus	0.3	0.5	1.3	0.3	-1.2	0.4	0.5
Blood Eosinophil Count	0.3	2.5	4.7	2.1	0.0	0.8	2.2
BMI	0.3	1.7	4.0	1.2	-0.6	1.1	2.0
Neuroticism	0.3	0.7	1.9	-0.9	-1.4	-0.4	-0.4
Hair Pigment	0.3	7.3	8.9	2.8	2.2	2.7	3.0
Relative age of first facial hair	0.3	0.7	0.9	0.9	0.9	-0.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	-0.1	1.0	-0.2	-0.1
Supplements: Zinc	0.3	0.3	0.6	-0.8	0.1	0.7	0.5
Pack years adult smoking proportion	0.3	0.4	0.8	-0.9	-0.7	-0.2	-0.5
Impedance of leg (right)	0.3	1.5	5.9	-0.2	2.4	0.2	-0.4
Current tobacco smoking	0.3	0.5	1.0	-0.5	-0.6	-1.0	-0.5
Average weekly fortified wine intake	0.3	0.4	1.3	1.1	-0.2	-0.2	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.0	1.4	-0.0	0.2	0.8
Fluid intelligence score	0.3	0.5	1.2	-1.1	-0.5	-0.5	-0.7
Neuroticism score	0.3	0.7	1.0	-1.0	-0.9	-0.6	-0.8
Arm fat percentage (right)	0.3	1.2	2.2	1.4	0.4	0.6	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.1	0.4	1.0	0.1	0.5
Mouth/teeth dental problems: Dentures	0.3	0.4	0.9	-0.2	-0.9	-0.8	-0.4
Impedance of arm (left)	0.3	1.2	3.1	0.8	1.8	-0.8	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.2	-1.1	0.6	0.1	-0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	-0.3	-0.5	-0.7	-1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.5	1.2	-0.0	0.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.5	0.7	0.6	0.5	-0.2
Medication: Aspirin	0.3	0.4	1.1	-0.1	-1.0	-0.6	-0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	1.0	0.2	0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.3	-0.8	-0.2	0.8
Friendships satisfaction	0.3	0.4	0.7	-0.7	0.6	0.1	-0.8
Number of self-reported non-cancer illnesses	0.3	0.5	1.4	1.2	-0.6	-0.3	-0.4
Miserableness	0.3	0.6	1.2	-0.9	-1.1	-0.3	-0.4
Hearing aid user	0.3	0.4	0.7	0.7	0.0	0.8	0.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	-0.2	-0.9	-0.2	-0.8
Medication: Blood pressure	0.3	0.6	1.8	0.1	-0.4	-0.5	-1.3
Number of operations (self-reported)	0.3	0.5	1.4	0.5	-1.2	-0.3	0.4
Fractured/broken bones in last 5 years	0.3	0.4	0.8	-0.9	-0.6	0.1	-0.7
Age started oral contraceptive pill	0.3	0.4	0.8	-0.9	-0.4	-0.7	-0.2
Pack years of smoking	0.3	0.5	1.2	-1.1	-0.8	-0.1	-0.4
HDL Cholesterol	0.2	0.4	1.6	0.1	-0.2	0.0	1.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	-0.4	-0.7	-0.3	-0.6
Sensitivity / hurt feelings	0.2	0.4	1.3	1.1	0.0	0.4	-0.1
Medication for hormone replacement therapy	0.2	0.3	0.6	0.6	0.4	0.1	0.7
Severe depression (siblings)	0.2	0.3	0.6	-0.1	-0.8	0.3	-0.6
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.7	0.5	0.2	0.6
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.7	0.0	0.5	0.5
Multivitamins +/- minerals	0.2	0.2	0.6	0.8	0.1	0.4	-0.4
Body mass index (BMI)	0.2	0.7	1.6	0.6	-0.8	0.6	1.3
Had other major operations	0.2	0.2	0.3	-0.6	-0.5	-0.6	-0.3
Diabetes (self-reported)	0.2	0.4	1.0	0.0	-0.0	-0.7	-1.0
Alcohol intake versus 10 years previously	0.2	0.3	0.7	0.1	0.4	0.7	0.8
Hair/balding pattern: Pattern 4	0.2	0.6	1.0	-1.0	-0.5	-0.5	-0.8
Pulse wave reflection index	0.2	0.2	0.6	-0.3	0.5	0.8	-0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.4	0.6	0.3	-0.6	-0.5
High blood pressure (siblings)	0.2	0.2	0.5	0.4	-0.7	-0.1	0.4
Had major operations	0.2	0.3	0.9	0.1	-1.0	0.0	0.3
Arm fat percentage (left)	0.2	0.6	1.5	1.0	-0.0	0.2	1.2
Ever had bowel cancer screening	0.2	0.3	0.5	-0.4	0.3	-0.7	-0.6
Medication for cholesterol	0.2	0.3	0.6	-0.8	0.3	0.4	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	-0.1	-0.9	-0.5	0.1
Mineral and other dietary supplements	0.2	0.3	0.4	0.6	-0.6	-0.7	0.1
Breast cancer (self-reported)	0.2	0.3	0.9	1.0	-0.3	-0.4	0.2
Medication: Aspirin	0.2	0.2	0.6	0.3	-0.8	-0.2	0.4
Smoking status: Current	0.2	0.4	0.7	-0.5	-0.5	-0.8	-0.5
Cholesterol lowering medication	0.2	0.3	0.8	0.9	0.1	0.0	-0.7
Supplements: Calcium	0.2	0.2	0.6	-0.3	0.4	0.8	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.7	0.9	0.1	0.2	-0.3
Crohns Disease (2017)	0.1	0.2	0.4	-0.6	-0.4	0.3	0.1
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.1	0.1	0.5	0.4
Schizophrenia (2014)	0.1	0.3	0.8	-0.5	-0.2	0.4	0.9
Blood Platelet Count	0.1	1.2	4.3	2.1	0.7	0.1	0.2
Blood Red Count	0.1	0.7	1.6	0.4	1.3	0.7	0.7
Lung FVC	0.1	0.3	0.5	-0.3	0.5	-0.7	-0.6
Chronotype (morning person)	0.1	0.1	0.2	0.4	0.5	-0.4	0.0
Tanning	0.1	1.1	2.2	-1.3	0.3	-0.6	-1.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	-0.5	-0.4	0.1	0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	-0.6	0.1	-0.3	-0.2
Diabetes (father)	0.1	0.1	0.2	0.2	0.4	-0.4	0.1
Taking other prescription medications	0.1	0.1	0.3	0.6	0.2	0.1	-0.4
High blood pressure (mother)	0.1	0.1	0.2	0.5	-0.2	0.1	0.0
Qualifications: None of the above	0.1	0.2	0.4	0.4	0.5	0.4	0.6
Financial difficulties in last 2 years	0.1	0.2	0.3	0.5	-0.1	0.4	0.5
Illnesses of siblings	0.1	0.1	0.2	0.5	0.5	0.1	-0.3
Father’s age at death	0.1	0.1	0.2	-0.1	0.4	-0.3	-0.2
Falls in the last year	0.1	0.2	0.5	0.4	-0.7	0.1	-0.1
Happiness	0.1	0.1	0.3	0.4	0.4	0.5	-0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.4	-0.3	-0.4	-0.7
Headache pain in last month	0.1	0.1	0.5	0.1	0.1	-0.3	-0.7
Medication: Amlodipine	0.1	0.2	0.7	0.2	-0.8	0.2	0.1
Leg fat percentage (right)	0.1	0.5	1.5	0.4	0.4	0.5	1.2
Number of full brothers	0.1	0.1	0.2	0.1	0.5	-0.2	-0.2
Qualifications: College or University degree	0.1	0.2	0.7	-0.3	-0.8	0.0	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.1	-0.2	-0.5	-0.5
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.5	0.3	-0.1	-0.0
Heart disease (mother)	0.1	0.1	0.5	0.2	0.2	-0.1	0.7
Illnesses of father: Heart disease	0.1	0.1	0.3	0.1	-0.1	0.5	0.5
Diabetes diagnosed by doctor	0.1	0.1	0.4	0.2	0.2	-0.1	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.5	0.2	-0.6	0.5
Mother’s age at death	0.1	0.2	0.3	-0.2	0.3	-0.6	-0.5
Medication: Paracetamol	0.1	0.2	0.4	0.5	-0.6	0.1	0.4
Leg fat percentage (left)	0.1	0.3	1.0	-0.1	0.4	0.4	1.0
Average weekly beer plus cider intake	0.1	0.2	0.7	-0.8	0.0	-0.1	-0.2
Risk taking	0.1	0.2	0.3	0.3	-0.5	0.5	0.5
Diastolic blood pressure, automated reading	0.1	0.3	0.6	-0.7	-0.8	-0.2	-0.3
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.5	-0.2	-0.1	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.5	0.3	-0.3	-0.2
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.4	-0.0	-0.6	-0.4	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.1	0.2	0.1	-0.4	0.1	0.2
Medication: Co-codamol	0.0	0.0	0.1	-0.1	0.1	-0.0	0.3
Neck or shoulder pain in last month	0.0	0.1	0.1	-0.2	0.4	0.1	-0.0
Chest pain or discomfort	0.0	0.1	0.2	-0.1	-0.2	-0.1	-0.5
Average weekly red wine intake	0.0	0.1	0.1	-0.3	-0.3	0.2	0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.1

Hub : Genes

DCI

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Trait associations