Hub : Genes

DDA1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0329	0.0109	4.2e-04	0.002	0.011	0.003	0.012	0.003	7.1e-02	1.4e-04	2.5e-02	8.4e-05	3.2e-02
2	YFS	Blood	0.1686	0.0236	0.0e+00	0.133	0.136	0.158	0.159	0.160	3.1e-41	4.3e-42	4.0e-49	1.7e-49	7.0e-50
3	TCGA	Thyroid Carcinoma	0.2480	0.1620	6.4e-06	0.025	0.059	0.092	NA	0.038	1.6e-03	2.0e-06	3.2e-09	NA	1.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.1	2.9	0.6	-1.7	0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	1.2	0.8	-1.1	0.3
Depressed Affect (Nagel 2018)	0.3	0.6	1.3	0.2	1.1	-0.6
Depression (Nagel 2018)	0.8	1.2	1.9	1.3	1.4	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.0	-1.0	-0.3	0.3
Neuroticism (Nagel 2018)	0.6	1.4	2.6	-0.2	1.6	-1.3
Schizophrenia (2018)	0.1	0.2	0.4	0.6	-0.0	0.3
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	-0.2	0.6	-0.2
Worry (Nagel 2018)	1.0	2.0	4.9	0.3	2.2	-1.1
Alzheimer’s Disease (in mother)	0.4	0.5	0.6	0.8	0.6	-0.8
Alzheimer’s Disease (in father)	3.6	3.9	7.0	1.4	1.6	-2.6
Alzheimer’s Disease (including proxy)	2.4	3.5	7.1	1.8	0.5	-2.7
Crohns Disease (2017)	0.0	0.1	0.1	-0.1	-0.1	-0.4
Irritable Bowel Disease (IBD)	0.6	1.5	2.7	-1.2	-1.6	-0.7
Ulcerative Colitis (UC)	1.2	2.2	4.2	-1.4	-2.1	-0.5
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	2.1	4.1	12.0	0.1	0.4	-3.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.6	0.3	-0.4
Breast Cancer	2.0	4.9	9.9	-3.1	0.3	2.1
Ovarian Cancer	7.9	10.5	18.7	-4.3	-1.3	3.3
Prostate Cancer	3.2	4.5	9.5	3.1	-0.1	-2.0
Age at First Birth	0.1	0.1	0.4	-0.6	0.1	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	3.5	-0.7	-1.9	-0.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.4	0.9	-0.9	-0.4	-0.2
Mean Putamen Volume	0.2	0.3	0.7	-0.9	0.1	-0.0
Fasting Glucose	0.4	0.4	1.0	0.2	-1.0	0.5
HbA1C	0.2	0.2	0.2	0.5	0.4	-0.5
HDL Cholesterol	1.6	2.6	7.8	-0.1	2.8	-0.2
LDL Cholesterol	0.5	0.7	1.8	1.4	-0.4	-0.4
Lupus	1.9	2.8	5.1	-2.3	-1.6	0.9
Neuroticism (2016)	0.7	1.0	1.4	-0.6	1.2	-1.1
Primary Biliary Cirrhosis	1.4	2.0	4.0	-2.0	-0.2	-1.4
Rheumatoid Arthritis	0.9	1.2	1.8	-1.3	-1.3	0.3
Schizophrenia (2014)	0.2	0.4	0.6	0.8	-0.6	0.2
Triglycerides	1.0	1.7	4.5	-0.1	-2.1	0.7
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.5	-1.9	-1.8	0.0
Ulcerative Colitis	1.4	2.0	5.4	-0.7	-2.3	-0.3
Blood Eosinophil Count	0.3	2.1	5.0	2.2	1.2	0.2
Blood Platelet Count	0.1	1.6	4.3	2.1	0.3	-0.6
Blood Red Count	0.5	4.7	10.0	1.7	3.2	1.1
Blood White Count	0.5	3.6	9.4	1.2	0.1	3.1
Heel T-Score	1.6	12.7	20.7	4.5	3.9	1.5
BMI	0.2	1.1	1.8	0.3	-1.2	-1.4
Height	0.9	16.4	26.6	-5.2	-4.0	2.5
Waist Hip Ratio (WHR)	0.4	1.6	3.6	-0.2	1.1	1.9
Systolic Blood Pressure	0.4	2.1	6.1	-2.5	-0.4	-0.3
Smoking Status	0.2	0.4	1.0	-0.1	0.4	1.0
Allergy or Eczema	1.6	4.3	12.0	3.5	0.8	-0.4
Cardiovascular Disease	1.3	4.3	12.4	-3.5	-0.5	-0.4
Hypothyroidism (self reported)	1.4	3.2	8.2	0.9	0.8	-2.9
Respiratory disease	2.6	5.8	14.9	3.9	-0.5	1.5
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	-0.1	-0.5	-0.2
Lung FEV1/FVC ratio	0.0	0.2	0.4	0.3	0.7	0.3
Lung FVC	0.1	0.3	0.5	0.7	-0.5	-0.5
Neuroticism	0.3	0.6	1.7	-0.3	1.3	-0.0
Chronotype (morning person)	2.3	5.4	6.5	-2.5	-2.5	1.8
Hair Pigment	0.2	4.3	9.5	0.9	3.1	-1.6
Tanning	0.0	0.4	1.2	1.1	-0.2	0.1
Hand grip strength (left)	0.9	2.3	5.9	1.0	0.3	2.4
Number of treatments/medications taken	0.3	0.5	0.9	-0.9	0.4	-0.8
Average weekly spirits intake	0.8	1.0	1.7	-0.2	-1.3	1.1
Sensitivity / hurt feelings	1.1	1.8	5.3	0.3	0.2	-2.3
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.2	0.5	0.8	-1.5
Hearing difficulty/problems: Yes	0.7	1.1	2.1	1.1	-1.5	0.0
Relative age of first facial hair	0.3	0.7	0.7	0.8	0.8	0.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.4	-1.2	-0.8	1.0
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.7	0.9	1.6	0.6
Ever had hysterectomy (womb removed)	0.5	0.6	1.4	1.2	0.1	0.6
Systolic blood pressure, automated reading	0.6	1.8	2.2	-1.5	-1.3	-1.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	3.7	-0.4	0.8	-1.9
Angina	1.0	1.3	3.3	-0.2	-0.8	-1.8
Medication for hormone replacement therapy	1.0	1.2	2.5	1.6	1.0	0.2
Vitamin and mineral supplements	1.1	1.5	2.6	1.6	1.1	0.9
Supplements: Zinc	0.4	0.4	1.1	0.2	1.1	0.0
Medication: Co-codamol	0.3	0.3	0.6	0.2	0.8	0.5
Medication: Metformin	1.0	1.4	3.9	-0.3	0.2	-2.0
Diabetes (father)	0.7	0.9	1.9	-1.4	-0.6	-0.6
Diabetes (mother)	0.5	0.6	1.1	-0.7	-0.5	1.0
Severe depression (siblings)	1.3	1.5	3.5	-0.8	1.9	0.5
Pack years adult smoking proportion	0.2	0.4	0.5	0.7	0.5	0.6
Impedance of leg (right)	0.4	1.8	3.8	-1.9	0.5	1.1
Leg fat-free mass (left)	0.2	1.3	2.0	-0.8	-1.4	1.2
Trunk fat percentage	0.3	1.2	1.8	-1.3	-1.3	0.2
Hand grip strength (right)	1.2	3.2	9.3	0.2	-0.6	3.0
Townsend deprivation index at recruitment	0.2	0.2	0.4	0.1	-0.6	0.5
Current tobacco smoking	0.7	1.2	2.4	0.9	0.5	1.6
Average weekly fortified wine intake	0.2	0.3	0.7	-0.8	-0.2	-0.1
Maternal smoking around birth	0.7	1.0	2.4	0.5	1.5	0.7
Fed-up feelings	0.6	1.0	2.9	0.4	1.7	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	3.3	1.7	1.8	-0.8
Relative age voice broke	0.9	1.4	2.9	-0.1	1.7	-1.1
Taking other prescription medications	1.4	2.2	4.0	1.5	2.0	0.6
Age when periods started (menarche)	0.4	0.9	1.8	-0.1	-0.9	1.3
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	2.2	1.4	1.5	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.3	1.5	0.2	0.4
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	1.7	-1.3	-1.2	1.1
Qualifications: CSEs or equivalent	1.0	1.3	3.5	1.9	0.3	-0.6
Serious illness, injury or assault to yourself	1.6	1.9	3.1	-1.2	-1.1	1.8
High blood pressure	0.5	1.4	4.0	-2.0	0.2	0.3
Hayfever, allergic rhinitis or eczema	0.8	1.6	4.8	2.2	0.3	-0.0
Multivitamins +/- minerals	0.9	1.1	2.6	-1.6	-0.3	-0.8
Stomach or abdominal pain in last month	0.6	0.8	2.1	1.4	-0.5	0.1
Supplements: Glucosamine	3.2	4.2	8.9	-1.9	-3.0	0.3
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.4	1.6	0.1	-1.2
Medication: Atenolol	0.2	0.2	0.6	0.0	-0.7	0.1
Medication: Levothyroxine sodium	1.5	2.5	6.3	0.8	0.7	-2.5
Sitting height	0.7	4.8	7.3	-2.4	-1.2	2.7
Chronic bronchitis/emphysema (father)	0.4	0.4	0.7	0.5	0.6	-0.8
High blood pressure (mother)	0.3	0.4	1.3	0.0	-0.0	-1.2
Body mass index (BMI)	0.2	1.1	1.7	1.2	-0.2	-1.3
Impedance of leg (left)	0.4	1.8	4.6	-2.1	0.3	0.9
Leg predicted mass (left)	0.3	1.4	1.9	-0.8	-1.4	1.2
Trunk fat mass	0.4	1.5	2.3	-1.4	-1.5	0.5
Waist circumference	0.1	0.2	0.4	-0.3	-0.5	-0.6
Number of incorrect matches in round	0.2	0.3	0.4	0.5	0.5	-0.6
Past tobacco smoking	0.4	0.8	1.5	1.2	0.5	-0.7
Alcohol usually taken with meals	0.2	0.3	0.8	-0.3	-0.1	-0.9
Nervous feelings	0.6	1.2	3.1	0.2	1.8	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	1.5	1.2	1.2	-1.2
Hearing difficulty/problems with background noise	1.9	3.0	8.0	2.8	0.9	-0.5
Hair/balding pattern: Pattern 2	0.5	0.7	1.1	0.8	1.1	0.5
Had menopause	0.7	0.9	1.9	-0.8	-0.2	-1.4
Had other major operations	0.6	0.7	1.1	-0.6	-0.9	-1.0
Forced vital capacity (FVC)	1.0	3.7	6.5	-2.5	-1.8	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.3	2.1	0.4	0.6
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.6	-2.1	0.5	0.8
Qualifications: None of the above	0.0	0.1	0.2	0.1	-0.5	-0.2
Financial difficulties in last 2 years	1.7	2.2	2.8	1.7	1.6	1.2
Mouth/teeth dental problems	1.0	1.6	3.1	0.2	-1.2	1.8
Heart attack	1.2	1.5	2.5	-1.6	-1.0	-1.0
Allergy	2.6	5.9	16.6	-4.1	-0.6	-0.9
Pain all over the body in last month	1.8	2.0	2.8	1.7	1.1	1.4
Diabetes (self-reported)	0.5	0.8	1.8	-0.7	-0.5	-1.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.6	1.6	0.2	-0.3
Medication: Ramipril	1.1	1.4	2.9	0.1	-1.7	-1.1
Medication: Simvastatin	2.7	4.0	8.6	-2.9	-0.9	-1.6
Fluid intelligence score	0.1	0.3	0.8	-0.9	-0.0	-0.2
Illnesses of siblings	0.3	0.4	0.9	-0.5	0.2	-1.0
Neuroticism score	0.4	0.9	2.1	0.3	0.7	-1.5
Weight	0.2	1.0	2.2	-0.8	-1.5	0.5
Impedance of arm (right)	0.9	4.3	11.5	-3.4	-0.4	1.2
Arm fat percentage (right)	0.1	0.2	0.5	-0.2	-0.3	-0.7
Trunk fat-free mass	0.2	0.9	1.1	-1.0	-1.0	0.8
Hip circumference	0.1	0.4	0.9	-0.3	-1.0	-0.4
Time employed in main current job	0.0	0.0	0.1	-0.2	0.1	-0.3
Alcohol intake versus 10 years previously	0.3	0.4	1.0	0.4	1.0	0.4
Father’s age at death	1.4	1.9	4.7	0.2	1.0	-2.2
Worrier / anxious feelings	2.2	4.2	6.2	0.8	2.4	-2.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.3	1.2	0.7	0.0
Falls in the last year	0.0	0.0	0.0	0.2	-0.2	0.1
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	0.7	-0.4	-0.7
Number of live births	2.1	3.0	4.7	1.8	2.2	1.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	5.2	-2.3	-1.6	0.8
Pulse rate	0.5	0.9	2.6	0.1	0.2	1.6
Happiness	1.0	1.2	3.4	-0.0	1.8	0.3
Noisy workplace	0.2	0.2	0.6	0.2	-0.8	0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.9	-1.4	-0.9	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.1	0.3	0.9	1.5
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	-0.9	0.6	0.1
Asthma	2.2	4.4	12.5	3.5	-0.5	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.1	0.4	1.1	-0.7
Medication: Cholesterol lowering	2.1	3.3	8.8	-3.0	-0.8	-0.7
Depression (self-reported)	1.2	1.4	3.2	0.8	1.8	0.7
Medication: Lansoprazole	0.7	0.7	0.9	0.8	0.9	1.0
Prospective memory result	0.1	0.2	0.3	-0.4	-0.6	-0.2
Lung cancer (father)	4.6	5.4	10.6	3.3	2.0	-1.2
Illnesses of mother	0.2	0.3	0.8	-0.1	0.0	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.5	-1.6	-0.9	0.4
Pulse wave Arterial Stiffness index	1.3	1.5	2.6	-0.9	1.0	-1.6
Impedance of arm (left)	1.1	5.1	9.3	-3.0	-1.0	2.2
Arm fat mass (right)	0.0	0.1	0.2	-0.1	-0.5	-0.3
Trunk predicted mass	0.1	0.8	0.9	-0.9	-0.9	0.9
Standing height	1.4	13.7	18.7	-4.3	-2.6	4.0
Length of working week for main job	1.1	1.3	3.7	0.2	0.2	-1.9
Exposure to tobacco smoke at home	1.0	1.1	1.8	-1.3	1.3	0.2
Breastfed as a baby	0.5	0.6	1.2	-1.1	-0.5	-0.5
Tense / ‘highly strung’	0.7	1.2	1.4	0.9	1.2	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	6.1	0.6	2.5	-0.6
Hair/balding pattern: Pattern 4	1.1	2.6	5.2	-1.2	-2.3	-1.1
Birth weight of first child	0.7	1.2	1.9	-0.7	-1.1	-1.4
Peak expiratory flow (PEF)	0.9	2.0	4.0	-1.1	-2.0	0.9
Pulse wave reflection index	1.8	2.2	3.3	-1.6	0.8	-1.8
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.8	-0.7	0.5	-1.4
Loud music exposure frequency	2.1	2.3	4.6	-2.1	0.5	-1.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.1	-1.5	0.2	-0.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.0	0.7	1.1	-1.4
Blood clot in the leg (DVT)	1.2	1.6	3.8	0.6	2.0	0.7
Medication: Paracetamol	0.3	0.5	0.8	-0.7	0.5	0.9
Headache pain in last month	0.2	0.4	0.6	0.5	-0.8	-0.6
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	7.5	2.7	0.7	0.5
Glaucoma (self-reported)	2.2	2.6	4.5	-1.5	-2.1	-1.0
Gout (self-reported)	1.9	2.7	7.6	-2.8	0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.7	0.2	0.5	-1.9
Medication: Amlodipine	1.0	1.3	2.7	-1.0	1.6	-0.7
Medication: Ventolin 100micrograms inhaler	1.6	2.0	4.3	2.1	-0.1	-1.3
Birth weight	0.2	0.3	0.7	-0.1	-0.5	0.9
Chronic bronchitis/emphysema (mother)	2.2	2.5	7.2	-0.0	0.6	2.7
High blood pressure (siblings)	0.2	0.3	0.6	0.8	-0.2	-0.6
Forced vital capacity (FVC), Best measure	0.5	1.9	4.2	-2.1	-1.1	0.5
Body fat percentage	0.1	0.5	0.8	-0.7	-0.9	-0.5
Leg fat percentage (right)	0.1	0.4	0.9	-0.0	-0.3	-1.0
Arm fat-free mass (right)	0.1	0.7	1.3	-0.3	-1.1	0.8
Exposure to tobacco smoke outside home	0.5	0.7	1.4	-1.2	0.7	-0.1
Comparative body size at age 10	0.1	0.2	0.4	0.6	-0.3	-0.4
Number of full brothers	1.5	1.9	4.5	2.1	0.8	0.8
Worry too long after embarrassment	1.0	1.7	3.9	0.1	-1.1	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	5.4	1.8	2.3	0.3
Wheeze or whistling in the chest in last year	2.8	4.9	14.4	3.8	-0.5	-0.4
Number of children fathered	0.4	0.5	0.7	0.7	0.8	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	2.4	1.5	1.6	-0.2
Age at first live birth	0.6	1.1	2.7	-0.8	-1.6	0.3
Pulse wave peak to peak time	1.6	1.9	3.4	0.3	-1.4	1.9
Health satisfaction	0.7	0.9	2.3	0.0	1.5	0.7
Shortness of breath walking on level ground	1.2	1.4	4.2	-0.2	0.2	-2.0
Qualifications: College or University degree	0.2	0.5	1.5	-1.2	-0.2	0.3
Eye problems/disorders: None of the above	0.7	0.8	1.2	1.0	1.1	0.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.1	0.0	1.2	-1.5
Emphysema/chronic bronchitis	0.9	1.0	2.0	1.0	-0.2	1.4
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	0.9	-0.3	-0.4
Neck or shoulder pain in last month	0.0	0.1	0.1	0.1	-0.2	-0.3
Medication: Blood pressure	1.8	3.2	6.8	-2.6	-0.9	-1.4
Angina (self-reported)	0.9	1.1	3.3	0.1	-0.2	-1.8
Migraine (self-reported)	1.1	1.4	2.5	1.3	0.0	1.6
Medication: Ibuprofen	0.5	0.6	1.0	0.3	0.9	-1.0
Medication: Allopurinol	1.0	1.3	3.2	-1.8	-0.6	0.6
Medication: Omeprazole	0.3	0.4	1.1	-0.1	-1.1	-0.3
Medication: Seretide 50 evohaler	1.8	2.0	4.2	-0.6	-2.0	1.3
Mean time to correctly identify matches	1.5	3.0	8.0	-0.9	-0.1	-2.8
Heart disease (mother)	0.1	0.1	0.4	-0.2	0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.4	-1.1	-1.9	-0.9
Whole body fat mass	0.1	0.6	1.0	-0.8	-1.0	0.2
Leg fat mass (right)	0.0	0.2	0.3	-0.4	-0.5	-0.3
Arm predicted mass (right)	0.2	0.9	1.7	-0.4	-1.3	0.8
Pulse rate, automated reading	0.1	0.3	0.6	0.1	0.5	0.8
Alcohol intake frequency.	0.3	0.6	1.4	1.2	0.3	0.6
Comparative height size at age 10	1.5	8.4	10.1	-3.1	-2.3	3.2
Number of full sisters	0.3	0.4	1.0	0.2	-0.0	-1.0
Suffer from ‘nerves’	1.6	2.5	4.8	1.6	0.2	-2.2
Overall health rating	1.2	2.5	4.0	2.0	1.8	-0.2
Chest pain or discomfort	1.2	1.7	2.6	1.6	-1.1	-1.1
Had major operations	1.2	1.4	2.0	-1.1	-0.9	-1.4
Age at last live birth	0.6	0.8	2.5	-0.0	-1.6	0.0
Family relationship satisfaction	1.0	1.2	3.5	-0.4	1.9	-0.1
Leg pain on walking	0.3	0.3	0.6	-0.4	0.5	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.1	0.5	0.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	2.2	0.8	-1.5	1.5
Illness, injury, bereavement, stress in last 2 years	3.1	3.8	8.4	-0.8	-1.5	-2.9
Medication: Aspirin	0.8	1.1	2.7	-1.6	0.2	0.8
Supplements: Vitamin C	0.7	0.8	2.3	-0.2	-1.5	-0.0
Knee pain experienced in last month	0.4	0.6	1.4	-0.4	-0.4	-1.2
Hypertension (Self-reported)	0.8	2.2	6.4	-2.5	-0.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.0	0.3	-0.5	1.4
Illnesses of father: Heart disease	1.5	2.1	5.0	-1.2	-2.2	0.0
Illnesses of siblings: Diabetes	0.2	0.2	0.4	-0.6	-0.4	-0.4
Smoking status: Previous	0.2	0.2	0.3	-0.5	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.8	11.2	-3.3	-2.5	0.1
Whole body fat-free mass	0.2	1.0	1.3	-0.9	-1.2	0.9
Leg fat-free mass (right)	0.3	1.5	2.6	-0.9	-1.6	1.0
Arm fat percentage (left)	0.0	0.2	0.4	0.0	-0.6	-0.4
Average weekly red wine intake	0.6	0.9	1.5	0.9	-1.2	0.6
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.5	0.1	0.6	-0.7
Mood swings	0.7	1.3	2.0	1.0	1.4	-1.0
Loneliness, isolation	0.8	1.1	2.8	0.7	-0.0	-1.7
Long-standing illness, disability or infirmity	0.3	0.4	1.0	-0.4	-0.3	1.0
Ever had bowel cancer screening	0.5	0.6	1.6	-0.1	0.5	-1.3
Diabetes diagnosed by doctor	0.7	1.2	1.7	-1.3	-0.5	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.5	0.5	-1.2	-0.3
Friendships satisfaction	1.1	1.3	3.7	0.1	1.9	0.6
Qualifications: nursing, teaching	0.4	0.7	0.9	-0.8	-0.7	-0.9
Commuting to job workplace: Walk	1.2	1.3	1.5	1.1	1.2	-1.0
Eye problems/disorders: Cataract	0.6	0.7	1.9	-0.4	0.1	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	3.1	0.7	1.0	-1.8
Medication for cholesterol	0.9	1.4	2.9	-0.4	-1.7	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.1	-1.3	-0.3	1.8
Back pain experienced in last month	0.1	0.2	0.4	-0.3	-0.5	0.6
Mineral and other dietary supplements	3.8	5.1	10.5	2.2	3.2	-0.4
Breast cancer (self-reported)	1.5	1.8	2.3	1.5	1.5	1.0
Asthma (self-reported)	2.4	4.7	13.1	3.6	-0.6	0.8
Osteoporosis (self-reported)	1.5	1.9	4.3	2.1	0.4	1.1
Osteoarthritis (self-reported)	1.5	1.9	3.7	-1.9	-1.4	-0.2
Medication: Aspirin	1.2	1.6	4.6	-2.1	-0.2	0.4
Medication: Gliclazide	1.0	1.2	1.5	-1.2	1.2	0.7
Illnesses of father: None of the above (group 1)	0.9	1.1	1.5	1.2	0.8	1.0
Smoking status: Current	0.5	0.7	0.9	0.8	0.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	-0.2	-0.6	0.2
Whole body water mass	0.2	1.0	1.4	-0.8	-1.2	0.9
Leg predicted mass (right)	0.3	1.4	2.4	-0.9	-1.5	1.0
Arm fat mass (left)	0.0	0.1	0.3	-0.1	-0.6	-0.3
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.4	-0.3	-0.0
Average weekly champagne plus white wine intake	0.8	1.1	2.8	-1.7	-0.8	-0.0
Miserableness	0.9	1.6	2.3	0.4	1.5	-1.5
Guilty feelings	0.8	1.3	3.5	-0.5	-0.2	-1.9
Wears glasses or contact lenses	0.3	0.4	0.6	-0.3	-0.7	-0.8
Ever taken oral contraceptive pill	0.3	0.3	0.4	0.5	0.6	0.6
Hearing aid user	0.3	0.3	0.6	-0.5	-0.4	0.8
Mother’s age at death	0.5	0.6	1.2	-0.3	0.6	1.1
Financial situation satisfaction	0.8	0.9	2.0	-0.7	1.4	0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.5	0.2	-1.2	-0.4
Commuting to job workplace: Public transport	0.2	0.3	0.5	-0.6	0.7	0.1
Eye problems/disorders: Glaucoma	1.6	1.9	3.8	-1.3	-2.0	0.3
Medication: Blood pressure	0.7	1.4	3.1	-1.8	0.9	0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.2	-1.1	-0.7	0.6
Supplements: Fish oil (including cod liver oil)	2.2	2.9	5.3	-1.6	-2.3	0.9
High cholesterol (Self-reported)	0.3	0.6	0.8	-0.8	0.5	-0.9
Medication: Bendroflumethiazide	0.6	1.0	1.4	-1.2	-0.4	-1.2
Medication: Paracetamol	0.3	0.5	0.7	-0.5	0.7	0.8
Medication: Lisinopril	0.6	0.7	1.1	-1.0	0.1	1.1
Medication: Atorvastatin	0.8	1.0	1.7	0.2	1.3	-1.1
Illnesses of father: High blood pressure	1.1	1.3	2.2	-1.2	-0.7	-1.5
Alcohol drinker status: Never	0.9	1.0	1.5	1.2	1.2	-0.0
Ever smoked	0.9	1.5	2.6	-1.6	-1.4	0.1
Basal metabolic rate	0.2	1.0	1.4	-0.8	-1.2	0.9
Leg fat percentage (left)	0.1	0.4	1.1	0.0	-0.4	-1.0
Arm fat-free mass (left)	0.0	0.1	0.1	-0.3	-0.4	0.0
Number of operations (self-reported)	0.5	0.8	1.7	-1.3	-0.4	-0.7
Average weekly beer plus cider intake	0.5	0.7	1.1	-0.5	1.0	-0.9
Irritability	1.1	1.9	3.7	-0.0	1.9	1.4
Risk taking	0.1	0.1	0.3	-0.2	0.5	0.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.6	-0.3	0.2	1.3
Fractured/broken bones in last 5 years	0.2	0.3	0.4	0.6	0.6	0.1
Age started oral contraceptive pill	0.6	0.7	1.5	0.7	-0.3	-1.2
Diastolic blood pressure, automated reading	0.4	1.2	3.2	-0.6	-0.3	-1.8
Ever depressed for a whole week	1.1	1.3	3.0	-0.2	1.7	1.0
Unable to work because of sickness or disability	2.6	3.4	7.2	1.5	0.8	2.7
Commuting to job workplace: Cycle	1.5	1.8	4.5	-0.9	0.3	-2.1
Myopia	8.2	11.9	19.7	-4.4	-4.0	-0.6
Vascular/heart problems diagnosed by doctor	0.7	1.9	5.1	2.3	0.4	-0.6
Cholesterol lowering medication	1.8	2.6	4.8	0.5	1.7	-2.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.7	-0.6	-1.3	-0.6
Pain experienced in last month	0.3	0.5	1.0	-1.0	0.1	0.8
Supplements: Calcium	0.2	0.2	0.4	-0.3	-0.6	-0.5
Basal cell carcinoma (self-reported)	2.1	2.5	5.2	0.7	1.3	-2.3
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.0	-1.7	-1.2	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.2	0.9	1.8	0.4
Heart disease (siblings)	0.1	0.1	0.2	0.0	-0.4	0.3
Alcohol drinker status: Previous	2.2	2.5	4.5	-1.5	-0.9	2.1
Pack years of smoking	0.2	0.3	0.4	0.6	0.5	0.6
Impedance of whole body	0.5	2.8	6.2	-2.5	-0.3	1.4
Leg fat mass (left)	0.0	0.2	0.3	-0.3	-0.6	-0.3
Arm predicted mass (left)	0.0	0.1	0.3	-0.3	-0.5	0.1