Hub : Genes

DDHD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0810	0.0260	1.3e-06	0.051	0.058	0.072	0.07	0.081	7.9e-07	1.4e-07	3.8e-09	7.3e-09	4.8e-10
2	GTEx	Testis	0.1650	0.0660	1.0e-03	0.093	NA	0.130	NA	0.153	6.5e-05	NA	2.3e-06	NA	2.6e-07
3	TCGA	Brain Lower Grade Glioma	0.0527	0.0313	2.5e-05	0.037	0.036	0.021	NA	0.033	4.6e-05	4.9e-05	1.6e-03	NA	1.1e-04
4	TCGA	Uterine Corpus Endometrial Carcinoma	0.3500	0.1600	9.2e-03	0.024	0.018	0.087	NA	0.089	7.2e-02	1.0e-01	2.1e-03	NA	1.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	1.7	0.2	0.1	-0.4	-1.3
Bipolar Disorder or Schizophrenia	0.7	1.8	4.4	0.0	-1.2	1.2	-2.1
Depressed Affect (Nagel 2018)	0.9	1.8	2.4	1.4	-1.0	1.4	1.5
Depression (Nagel 2018)	1.6	2.4	8.1	1.2	-0.1	0.3	2.9
Intelligence (Savage-Jansen 2018)	1.8	5.4	9.9	1.7	-3.2	3.0	0.4
Neuroticism (Nagel 2018)	1.6	3.7	4.9	2.2	-1.9	2.2	1.3
Schizophrenia (2018)	1.0	2.2	3.4	-0.2	-1.6	1.9	-1.6
Schizophrenia vs Biploar Disorder	1.6	2.1	7.7	-0.6	0.2	-0.5	-2.8
Worry (Nagel 2018)	0.7	1.5	1.9	1.4	-1.2	1.4	0.8
Alzheimer’s Disease (in mother)	0.9	1.1	2.3	-1.2	-0.7	0.3	1.5
Alzheimer’s Disease (in father)	0.4	0.5	1.0	1.0	0.5	-0.7	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.5	1.2	-0.4	0.4	-0.7	1.1
Crohns Disease (2017)	0.2	0.4	0.7	-0.1	0.8	-0.9	0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	0.8	-0.1	-0.0	0.6
Ulcerative Colitis (UC)	0.8	1.5	2.2	1.3	-1.5	1.4	0.4
Major Depression (MDD)	0.5	0.6	1.5	1.0	-0.1	0.2	1.2
Reaction Time	0.1	0.2	0.4	-0.6	0.5	0.2	-0.4
Verbal and Numeric Reasoning (VNR)	3.7	8.9	13.5	3.3	-3.7	3.3	-0.3
Breast Cancer	0.2	0.4	0.8	0.5	-0.7	0.4	0.9
Ovarian Cancer	0.5	0.6	0.8	0.5	0.8	-0.9	0.8
Prostate Cancer	1.5	2.1	7.4	-2.7	0.6	-0.6	0.6
Age at First Birth	0.1	0.2	0.4	-0.6	0.3	-0.4	-0.2
Bipolar Disorder (2011)	1.5	1.5	2.5	1.1	-1.5	1.6	-0.0
Body Mass Index (BMI) (2010)	1.7	2.4	5.5	0.3	-2.3	2.0	-0.1
Coronary Artery Disease (CAD)	0.0	0.1	0.2	0.2	-0.1	-0.1	-0.4
Crohns Disease (2012)	0.2	0.4	0.6	-0.2	0.7	-0.5	-0.8
Mean Putamen Volume	1.0	1.1	2.1	0.6	-1.4	1.5	-0.1
Fasting Glucose	0.3	0.4	0.6	0.7	0.4	-0.8	-0.6
HbA1C	1.9	2.1	2.6	1.3	-1.6	1.2	-1.6
HDL Cholesterol	0.2	0.3	1.0	-1.0	0.2	-0.1	0.4
LDL Cholesterol	0.1	0.1	0.3	-0.5	0.4	0.0	-0.2
Lupus	1.5	2.3	5.4	2.3	-1.0	1.3	1.1
Neuroticism (2016)	0.9	1.3	3.4	1.8	-0.9	1.0	0.1
Primary Biliary Cirrhosis	1.7	2.5	4.3	1.5	-1.8	2.1	0.5
Rheumatoid Arthritis	0.9	1.2	2.2	0.7	-1.5	1.5	-0.4
Schizophrenia (2014)	1.0	2.1	5.5	0.3	-1.1	1.3	-2.4
Triglycerides	0.2	0.4	0.5	0.4	-0.7	0.6	-0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.4	0.6	0.4	-0.6	-0.6
Ulcerative Colitis	0.1	0.2	0.7	0.3	-0.3	0.1	0.8
Blood Eosinophil Count	0.1	0.6	0.9	0.8	-0.9	0.9	0.3
Blood Platelet Count	3.2	37.1	68.6	3.7	-8.3	7.8	-2.3
Blood Red Count	0.1	1.1	2.1	-0.1	1.3	-1.4	-0.7
Blood White Count	0.3	2.3	4.3	-0.3	2.0	-2.1	-0.9
Heel T-Score	1.9	15.3	23.5	2.9	4.4	-4.8	-3.2
BMI	1.4	8.1	14.0	3.7	-3.2	2.8	-0.5
Height	0.2	3.1	5.9	1.0	-2.4	2.3	-0.2
Waist Hip Ratio (WHR)	0.8	3.7	9.9	3.1	-1.7	0.9	-1.2
Systolic Blood Pressure	0.1	0.6	0.9	-1.0	-0.6	0.5	-0.9
Smoking Status	0.2	0.5	0.9	-0.6	-0.9	0.9	0.1
Allergy or Eczema	0.2	0.5	1.3	1.1	-0.2	0.2	0.9
Cardiovascular Disease	0.5	1.8	3.2	1.8	-0.7	1.4	-1.2
Hypothyroidism (self reported)	0.2	0.5	0.9	1.0	0.6	-0.8	0.1
Respiratory disease	0.9	1.9	4.9	2.2	-1.0	1.1	0.8
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.5	1.9	-1.5	0.7	-0.1
Lung FEV1/FVC ratio	0.5	2.7	7.1	-1.5	-0.7	1.1	2.7
Lung FVC	0.1	0.3	0.8	-0.2	0.3	0.4	0.9
Neuroticism	0.7	1.6	3.2	1.1	-1.4	1.8	-0.1
Chronotype (morning person)	0.3	0.6	1.3	-1.1	0.9	-0.6	0.1
Hair Pigment	0.0	0.5	0.9	0.8	-0.1	0.8	1.0
Tanning	0.0	0.3	0.6	-0.2	-0.8	0.7	0.0
Hand grip strength (left)	1.1	2.8	6.2	2.5	-1.0	0.6	-1.9
Number of treatments/medications taken	0.7	1.2	3.0	1.7	0.8	-1.1	-0.3
Average weekly spirits intake	2.7	3.3	6.3	1.0	-2.5	2.4	-0.2
Sensitivity / hurt feelings	1.8	3.0	5.1	1.5	-1.9	2.3	-1.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.4	1.6	0.2	-0.3	1.0
Hearing difficulty/problems: Yes	0.3	0.4	0.9	-0.5	0.5	-0.4	1.0
Relative age of first facial hair	0.2	0.4	0.8	0.9	-0.8	0.6	-0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.7	-0.3	0.2	0.8
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.2	-0.5	-0.2	1.1	2.1
Ever had hysterectomy (womb removed)	1.5	1.7	4.5	2.1	-1.2	1.0	0.3
Systolic blood pressure, automated reading	0.2	0.5	1.2	-0.2	-0.8	1.1	0.2
Eye problems/disorders: Diabetes related eye disease	2.4	2.7	10.4	3.2	-0.4	0.3	-0.2
Angina	0.9	1.2	2.8	-1.4	-0.0	0.4	1.7
Medication for hormone replacement therapy	0.9	1.0	2.3	1.5	-0.7	0.2	-1.0
Vitamin and mineral supplements	0.2	0.2	0.8	-0.9	-0.1	0.1	0.2
Supplements: Zinc	0.6	0.6	1.0	-0.8	0.9	-1.0	0.0
Medication: Co-codamol	0.1	0.1	0.2	-0.2	-0.5	-0.2	-0.3
Medication: Metformin	1.7	2.5	4.2	2.0	-1.8	1.4	-0.6
Diabetes (father)	0.9	1.1	2.9	1.7	-0.9	0.5	-0.8
Diabetes (mother)	2.6	3.3	4.7	1.5	-1.6	2.2	2.0
Severe depression (siblings)	2.7	3.0	4.5	2.1	-2.1	1.6	-0.6
Pack years adult smoking proportion	0.3	0.4	1.0	-1.0	0.1	-0.1	-0.9
Impedance of leg (right)	2.1	10.4	18.1	-4.3	3.4	-3.2	1.2
Leg fat-free mass (left)	2.0	10.5	15.7	3.8	-4.0	3.2	-1.0
Trunk fat percentage	0.1	0.6	1.7	0.3	-1.3	0.6	-0.4
Hand grip strength (right)	0.6	1.7	4.5	2.1	-0.8	0.4	-1.1
Townsend deprivation index at recruitment	0.7	1.0	1.3	-1.1	1.2	-0.9	0.7
Current tobacco smoking	0.3	0.5	1.1	-1.0	0.1	-0.1	0.9
Average weekly fortified wine intake	2.3	2.6	4.8	2.2	-1.4	1.8	-0.8
Maternal smoking around birth	1.1	1.5	1.8	1.3	-1.3	1.1	1.2
Fed-up feelings	2.0	3.6	5.1	2.2	-2.0	2.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.9	0.2	-0.2	0.9
Relative age voice broke	0.0	0.0	0.1	-0.3	-0.0	0.1	-0.3
Taking other prescription medications	0.5	0.8	3.1	1.8	0.0	-0.2	-0.5
Age when periods started (menarche)	0.2	0.5	1.7	0.5	-0.3	-0.2	-1.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.5	-0.1	0.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	6.4	2.5	0.5	-0.9	-0.9
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.5	-0.0	-0.3	-0.1	0.7
Qualifications: CSEs or equivalent	0.3	0.3	0.7	-0.4	-0.7	-0.0	0.8
Serious illness, injury or assault to yourself	0.7	0.8	1.1	1.1	-1.0	0.7	-0.8
High blood pressure	0.1	0.4	0.9	0.9	-0.2	0.7	0.2
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.9	1.7	-0.7	0.7	1.0
Multivitamins +/- minerals	0.7	0.9	1.8	0.1	1.2	-1.3	-0.6
Stomach or abdominal pain in last month	0.6	0.7	2.2	-1.5	0.5	-0.5	-0.3
Supplements: Glucosamine	0.5	0.7	1.1	1.0	-0.8	1.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	-0.0	-0.2	-0.1	0.0
Medication: Atenolol	0.1	0.2	0.4	-0.3	0.6	-0.3	0.2
Medication: Levothyroxine sodium	0.5	0.8	1.5	1.2	-0.9	0.8	-0.6
Sitting height	0.2	1.2	1.6	-0.8	-1.3	1.3	1.0
Chronic bronchitis/emphysema (father)	1.3	1.5	4.3	-0.4	1.0	-0.6	2.1
High blood pressure (mother)	0.6	0.8	1.2	0.8	-0.9	1.1	0.8
Body mass index (BMI)	1.1	4.5	8.1	2.8	-2.5	2.0	0.0
Impedance of leg (left)	1.6	7.9	17.4	-4.2	2.8	-2.5	0.6
Leg predicted mass (left)	2.0	10.4	15.5	3.8	-3.9	3.2	-0.9
Trunk fat mass	0.5	2.2	5.0	1.2	-2.2	1.5	-0.3
Waist circumference	2.0	7.2	12.0	3.2	-3.5	2.5	-0.7
Number of incorrect matches in round	0.3	0.5	1.1	-0.7	0.3	-0.7	-1.0
Past tobacco smoking	1.6	2.9	3.6	-1.8	1.9	-1.6	1.6
Alcohol usually taken with meals	0.8	1.4	3.3	-0.6	-0.4	1.3	1.8
Nervous feelings	0.3	0.6	1.9	0.8	-0.0	-0.2	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	4.6	1.4	-2.1	2.1	0.2
Hearing difficulty/problems with background noise	0.2	0.4	1.0	1.0	-0.4	0.3	0.4
Hair/balding pattern: Pattern 2	0.8	1.1	1.8	1.1	0.6	-1.0	1.3
Had menopause	0.2	0.2	0.6	-0.1	-0.2	0.4	0.8
Had other major operations	0.2	0.3	0.9	0.9	0.2	0.2	0.2
Forced vital capacity (FVC)	0.5	1.8	2.6	1.5	-1.6	1.4	0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	14.5	3.8	0.2	-0.5	-1.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.4	0.0	0.3	0.8
Qualifications: None of the above	0.5	1.1	1.9	0.6	-1.2	1.4	0.8
Financial difficulties in last 2 years	0.1	0.1	0.5	-0.1	0.2	-0.7	0.1
Mouth/teeth dental problems	0.2	0.4	1.2	0.1	0.4	-1.1	-0.3
Heart attack	0.3	0.4	1.1	0.3	-0.0	0.5	1.1
Allergy	0.4	1.0	2.1	-1.4	0.6	-0.6	-1.2
Pain all over the body in last month	0.9	1.0	1.9	1.0	-0.8	1.4	0.7
Diabetes (self-reported)	1.1	1.7	3.5	1.9	-1.5	1.1	-0.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	5.2	2.3	-0.8	0.7	-0.0
Medication: Ramipril	1.7	2.2	4.4	-0.1	-2.1	2.1	-0.4
Medication: Simvastatin	0.4	0.6	1.2	1.0	-0.4	0.2	1.1
Fluid intelligence score	1.3	2.6	3.6	1.3	-1.6	1.7	1.9
Illnesses of siblings	0.3	0.5	0.9	1.0	-0.0	0.3	-1.0
Neuroticism score	0.6	1.2	2.1	1.4	-1.1	1.1	-0.6
Weight	1.5	7.3	11.3	3.2	-3.4	2.8	-0.1
Impedance of arm (right)	1.8	8.5	20.6	-4.5	2.2	-2.8	-1.0
Arm fat percentage (right)	0.1	0.5	1.2	0.7	-1.1	0.3	-0.6
Trunk fat-free mass	1.9	10.7	16.9	4.1	-3.7	3.5	0.3
Hip circumference	1.0	4.4	8.6	1.9	-2.9	2.2	-0.6
Time employed in main current job	1.8	2.0	4.3	-0.9	1.7	-2.1	-0.2
Alcohol intake versus 10 years previously	0.9	1.3	4.0	2.0	-0.7	0.3	-0.8
Father’s age at death	0.3	0.5	1.1	-1.1	-0.2	0.2	0.8
Worrier / anxious feelings	0.1	0.2	0.6	0.5	-0.2	0.0	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	0.3	-0.2	0.1	-0.3
Falls in the last year	0.4	0.5	1.0	0.1	1.0	-1.0	-0.0
Hair/balding pattern: Pattern 3	0.6	0.8	1.2	-1.1	0.8	-0.7	0.9
Number of live births	0.8	1.1	1.5	-1.2	1.0	-0.8	1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	2.8	1.0	-1.6	1.7	1.5
Pulse rate	0.3	0.5	1.0	-0.1	0.8	-0.7	1.0
Happiness	0.2	0.3	0.7	-0.4	0.4	-0.2	-0.8
Noisy workplace	1.1	1.4	2.6	1.4	-0.7	0.6	1.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.3	1.1	0.5	-0.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.0	0.2	0.2	0.4
Mouth/teeth dental problems: Dentures	0.8	1.4	4.8	-2.2	0.2	0.4	0.7
Asthma	0.2	0.4	1.1	1.1	-0.2	0.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	4.3	1.2	-2.1	1.7	0.6
Medication: Cholesterol lowering	0.6	1.0	1.3	1.1	-1.1	1.0	-0.6
Depression (self-reported)	0.4	0.5	0.7	0.8	0.8	-0.7	-0.4
Medication: Lansoprazole	0.2	0.2	0.4	0.6	0.2	-0.4	0.6
Prospective memory result	0.3	0.4	0.7	-0.5	-0.7	0.5	-0.8
Lung cancer (father)	1.9	2.2	3.5	1.5	-1.2	1.2	1.9
Illnesses of mother	1.1	1.4	2.9	-0.3	1.7	-1.6	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	3.4	1.3	-1.8	1.7	1.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.5	-0.2	0.7	0.0	0.2
Impedance of arm (left)	1.5	6.7	16.0	-4.0	2.0	-2.5	-0.6
Arm fat mass (right)	0.9	3.6	6.6	2.1	-2.6	1.8	-0.5
Trunk predicted mass	1.8	10.1	16.3	4.0	-3.5	3.4	0.3
Standing height	0.3	3.3	6.5	1.2	-2.6	2.3	-0.2
Length of working week for main job	0.3	0.4	0.9	0.9	0.6	-0.5	0.2
Exposure to tobacco smoke at home	0.5	0.6	1.6	1.3	-0.5	0.6	-0.4
Breastfed as a baby	0.7	0.9	1.8	0.1	-1.1	1.3	0.6
Tense / ‘highly strung’	1.1	1.8	4.1	2.0	-1.1	1.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.8	-0.9	1.0	-0.9	2.0
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	-1.1	-0.3	0.5	-0.1
Birth weight of first child	0.8	1.5	2.0	0.6	1.3	-1.4	-1.4
Peak expiratory flow (PEF)	1.6	3.7	6.3	1.9	-2.5	2.2	0.4
Pulse wave reflection index	0.4	0.5	1.1	0.3	1.0	-0.6	-0.8
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	-0.7	0.4	-0.3	0.2
Loud music exposure frequency	0.5	0.6	0.7	-0.8	0.8	-0.9	-0.5
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	4.4	-0.0	2.0	-2.1	-1.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.3	1.5	0.5	-0.0	-0.3
Blood clot in the leg (DVT)	0.3	0.4	1.3	-0.4	-0.4	0.3	1.1
Medication: Paracetamol	1.0	1.6	3.8	1.5	0.2	-0.5	-2.0
Headache pain in last month	0.6	1.0	1.4	1.0	0.7	-1.1	-1.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.4	0.2	0.1	-0.3	0.7
Glaucoma (self-reported)	0.3	0.4	0.5	-0.7	0.4	-0.7	-0.6
Gout (self-reported)	0.8	1.1	3.5	-1.9	-0.2	0.5	0.7
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	2.8	1.7	-1.0	0.6	-0.2
Medication: Amlodipine	0.2	0.3	0.5	-0.7	-0.0	0.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.8	0.4	-1.2	1.3	0.8
Birth weight	0.3	0.7	2.1	1.5	-0.1	-0.2	-0.8
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.4	-0.3	0.3	-0.1
High blood pressure (siblings)	0.2	0.3	0.8	-0.5	0.2	-0.3	0.9
Forced vital capacity (FVC), Best measure	0.6	2.3	3.7	1.9	-1.8	1.4	0.5
Body fat percentage	0.1	0.3	0.9	0.3	-0.9	0.2	-0.2
Leg fat percentage (right)	0.1	0.3	0.5	0.7	-0.2	-0.3	0.6
Arm fat-free mass (right)	2.3	11.7	19.8	4.4	-3.8	3.5	0.1
Exposure to tobacco smoke outside home	0.9	1.2	1.9	-0.8	1.4	-1.3	0.6
Comparative body size at age 10	0.1	0.4	0.6	-0.8	0.5	-0.5	0.5
Number of full brothers	0.4	0.4	1.4	-1.2	-0.1	-0.3	-0.5
Worry too long after embarrassment	1.2	2.0	2.5	1.3	-1.6	1.5	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	7.7	-0.4	2.4	-2.8	-0.0
Wheeze or whistling in the chest in last year	0.7	1.2	2.2	0.9	-1.5	1.3	0.6
Number of children fathered	1.6	1.8	2.9	1.7	-1.0	1.3	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.2	-1.2	0.2	-0.2	-1.5
Age at first live birth	0.2	0.4	0.6	0.6	0.8	-0.6	0.3
Pulse wave peak to peak time	0.3	0.3	1.0	0.3	-1.0	0.2	-0.2
Health satisfaction	0.9	1.1	4.1	2.0	-0.4	0.5	-0.1
Shortness of breath walking on level ground	1.6	1.9	3.5	1.7	-0.9	0.4	-1.9
Qualifications: College or University degree	0.2	0.6	1.3	1.0	-0.3	0.2	-1.2
Eye problems/disorders: None of the above	0.9	1.0	2.3	-1.5	-1.0	0.9	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.2	0.2	0.1	0.0
Emphysema/chronic bronchitis	0.8	0.8	2.1	0.2	-1.5	0.9	-0.7
Medication for pain relief, constipation, heartburn	2.8	4.9	8.8	-3.0	2.4	-2.2	-0.3
Neck or shoulder pain in last month	1.1	1.5	3.4	0.9	0.7	-1.2	-1.8
Medication: Blood pressure	0.9	1.5	3.3	-1.8	1.0	-0.8	-1.1
Angina (self-reported)	0.7	0.9	2.2	-1.2	0.1	0.2	1.5
Migraine (self-reported)	0.2	0.2	0.6	0.1	0.8	-0.4	0.3
Medication: Ibuprofen	1.3	1.5	3.0	0.6	-1.7	1.4	0.8
Medication: Allopurinol	0.7	1.0	2.0	-1.4	-0.9	1.0	-0.3
Medication: Omeprazole	1.8	2.1	3.0	1.7	-1.7	1.4	-0.9
Medication: Seretide 50 evohaler	1.3	1.5	3.0	0.1	1.7	-1.7	-0.2
Mean time to correctly identify matches	0.2	0.3	0.4	-0.6	0.7	0.5	0.3
Heart disease (mother)	0.0	0.0	0.1	-0.0	-0.0	0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.1	1.4	-1.0	0.6	0.2
Whole body fat mass	0.7	3.1	6.3	1.5	-2.5	1.9	-0.2
Leg fat mass (right)	0.5	2.0	3.6	1.9	-1.8	1.2	0.1
Arm predicted mass (right)	2.4	12.0	21.3	4.6	-3.8	3.5	-0.1
Pulse rate, automated reading	1.0	3.4	8.0	-0.2	2.3	-2.8	-0.2
Alcohol intake frequency.	1.0	2.4	5.3	-0.6	2.0	-2.3	0.1
Comparative height size at age 10	0.0	0.3	0.4	0.1	-0.6	0.6	-0.5
Number of full sisters	2.0	2.4	4.2	0.2	-1.6	1.6	-2.1
Suffer from ‘nerves’	1.1	1.7	3.5	0.5	-1.6	1.9	-0.5
Overall health rating	0.6	1.3	2.3	0.9	1.2	-1.5	-0.9
Chest pain or discomfort	0.3	0.4	0.8	-0.4	0.8	-0.9	-0.3
Had major operations	0.4	0.4	0.7	-0.6	0.9	-0.7	-0.5
Age at last live birth	0.1	0.1	0.1	0.3	0.4	-0.3	0.2
Family relationship satisfaction	0.0	0.0	0.1	0.3	0.2	-0.2	-0.2
Leg pain on walking	3.0	3.7	5.8	2.1	-2.4	2.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	5.7	0.3	1.9	-2.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.6	-0.1	1.3	-1.0	0.8
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.6	-1.2	1.6	-1.5	-0.5
Medication: Aspirin	3.2	4.2	7.4	1.1	-2.1	2.7	2.0
Supplements: Vitamin C	0.2	0.3	0.5	0.7	-0.4	0.3	-0.6
Knee pain experienced in last month	0.6	0.9	2.6	0.4	0.5	-0.8	-1.6
Hypertension (Self-reported)	0.2	0.7	1.5	1.2	-0.5	0.9	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	0.6	0.3	-0.5	0.6
Illnesses of father: Heart disease	0.1	0.2	0.2	-0.4	-0.5	0.4	-0.4
Illnesses of siblings: Diabetes	0.8	0.9	2.0	-0.1	-1.3	1.4	0.3
Smoking status: Previous	1.7	2.6	3.9	1.4	-2.0	1.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	3.7	1.4	-1.9	1.5	-0.4
Whole body fat-free mass	2.0	11.5	17.2	4.2	-4.0	3.6	-0.3
Leg fat-free mass (right)	2.4	12.6	18.6	4.1	-4.3	3.6	-1.3
Arm fat percentage (left)	0.2	0.7	1.5	1.0	-1.2	0.4	-0.6
Average weekly red wine intake	0.3	0.4	1.6	-1.3	0.2	0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.2	0.8	-0.7	0.1
Mood swings	1.5	2.6	4.5	0.9	-1.9	2.1	-1.3
Loneliness, isolation	1.4	1.9	5.1	2.2	-1.1	1.0	-0.6
Long-standing illness, disability or infirmity	1.0	1.6	2.4	0.9	-1.4	1.6	1.1
Ever had bowel cancer screening	1.6	1.9	3.9	-0.2	1.7	-2.0	0.7
Diabetes diagnosed by doctor	2.0	3.2	6.1	2.5	-2.1	1.6	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.1	-0.1	-1.1	0.7	0.9
Friendships satisfaction	1.8	2.2	3.8	1.3	-2.0	1.8	-0.6
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.3	0.0	0.5	0.4
Commuting to job workplace: Walk	0.6	0.7	1.5	0.6	-1.2	0.8	-0.4
Eye problems/disorders: Cataract	0.8	0.9	2.0	0.5	1.0	-0.7	1.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.8	-0.4	0.6	0.2
Medication for cholesterol	1.1	1.7	4.9	-2.2	0.8	-1.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.1	1.0	-0.5	0.3	0.6
Back pain experienced in last month	0.7	1.0	2.6	1.6	0.7	-0.6	0.9
Mineral and other dietary supplements	0.3	0.3	1.2	-1.1	-0.4	0.1	-0.0
Breast cancer (self-reported)	0.8	0.9	1.9	1.4	0.3	0.2	-1.2
Asthma (self-reported)	0.5	0.9	2.6	1.6	-0.4	0.4	0.9
Osteoporosis (self-reported)	0.2	0.3	0.6	0.8	-0.0	0.6	0.3
Osteoarthritis (self-reported)	1.0	1.3	2.0	1.4	-1.4	1.1	0.2
Medication: Aspirin	2.1	2.7	4.8	0.6	-1.6	2.2	1.7
Medication: Gliclazide	0.7	0.8	2.7	1.6	0.2	-0.5	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.3
Smoking status: Current	0.2	0.3	0.7	-0.9	0.3	-0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.2	0.7	-1.1	1.0	0.9
Whole body water mass	2.2	12.3	18.4	4.3	-4.1	3.7	-0.5
Leg predicted mass (right)	2.4	12.7	18.7	4.1	-4.3	3.7	-1.3
Arm fat mass (left)	0.9	3.7	6.6	2.1	-2.6	1.9	-0.7
Number of self-reported non-cancer illnesses	0.5	0.9	2.3	1.5	0.9	-0.7	0.5
Average weekly champagne plus white wine intake	0.6	0.8	1.7	-0.7	-0.5	0.9	1.3
Miserableness	0.4	0.7	1.9	1.4	-0.3	0.5	-0.7
Guilty feelings	0.8	1.3	2.0	1.1	-1.4	1.3	-0.4
Wears glasses or contact lenses	0.4	0.4	1.5	-0.0	0.4	-0.3	1.2
Ever taken oral contraceptive pill	0.4	0.5	1.3	0.3	-0.6	1.1	-0.4
Hearing aid user	1.2	1.4	3.2	-0.1	-1.5	1.8	-0.3
Mother’s age at death	0.0	0.1	0.2	-0.0	0.4	-0.2	-0.0
Financial situation satisfaction	2.2	2.7	3.4	-1.8	1.8	-1.6	1.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.9	-0.1	-0.9	0.9	0.9
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.1	-0.5	0.4	0.2
Eye problems/disorders: Glaucoma	0.3	0.4	1.3	0.1	0.2	-0.4	-1.1
Medication: Blood pressure	0.7	1.4	4.8	2.2	0.1	0.4	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.5	-0.3	-0.2	-0.7
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.5	1.1	0.4	0.0	1.6
High cholesterol (Self-reported)	0.9	1.6	2.4	1.5	-1.5	1.4	-0.0
Medication: Bendroflumethiazide	0.7	1.1	2.6	1.6	-0.3	1.0	0.9
Medication: Paracetamol	0.7	1.2	2.0	1.0	0.7	-1.0	-1.4
Medication: Lisinopril	2.0	2.6	5.4	2.3	-1.1	1.4	-1.4
Medication: Atorvastatin	0.3	0.3	0.5	-0.6	-0.6	0.7	0.1
Illnesses of father: High blood pressure	0.2	0.3	0.6	0.3	0.4	-0.5	-0.8
Alcohol drinker status: Never	2.7	3.2	5.9	-2.4	1.9	-1.9	-0.2
Ever smoked	1.1	2.0	4.1	2.0	-1.4	1.2	-0.8
Basal metabolic rate	2.0	11.2	16.7	4.1	-4.0	3.5	-0.4
Leg fat percentage (left)	0.1	0.4	0.9	0.9	-0.6	0.2	0.4
Arm fat-free mass (left)	2.3	11.7	18.7	4.3	-3.9	3.6	-0.3
Number of operations (self-reported)	1.3	1.9	5.3	2.3	1.0	-0.8	-0.8
Average weekly beer plus cider intake	2.2	3.1	8.0	0.7	-1.6	1.2	-2.8
Irritability	1.2	2.0	4.1	2.0	-1.3	1.5	0.2
Risk taking	1.0	1.5	2.2	0.9	-1.1	1.4	-1.5
Ever had prostate specific antigen (PSA) test	1.5	1.8	2.6	0.7	1.1	-1.6	-1.6
Fractured/broken bones in last 5 years	1.3	1.6	3.1	0.8	-1.7	1.7	-0.0
Age started oral contraceptive pill	1.2	1.5	2.7	-0.9	1.6	-0.7	1.3
Diastolic blood pressure, automated reading	0.1	0.3	0.9	-0.3	-0.2	0.0	-0.9
Ever depressed for a whole week	0.7	0.8	3.1	-1.8	0.4	-0.2	-0.0
Unable to work because of sickness or disability	0.4	0.5	1.8	1.4	-0.1	-0.2	-0.5
Commuting to job workplace: Cycle	0.2	0.3	0.5	-0.6	0.5	-0.7	-0.2
Myopia	1.2	1.7	3.7	-1.9	1.3	-1.2	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.9	-0.7	0.3	-1.0	-0.4
Cholesterol lowering medication	0.9	1.3	1.9	0.9	-1.4	1.3	0.8
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	4.0	2.0	-1.5	1.0	-0.9
Pain experienced in last month	0.8	1.3	2.8	-1.7	-0.4	0.9	1.3
Supplements: Calcium	0.5	0.5	0.9	-0.9	0.9	-0.5	-0.5
Basal cell carcinoma (self-reported)	2.7	3.3	5.2	1.6	-2.3	2.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.0	0.5	0.1	0.4	1.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	-0.6	-0.3	0.2	0.8
Heart disease (siblings)	0.3	0.4	0.8	0.5	-0.9	0.6	-0.3
Alcohol drinker status: Previous	0.3	0.4	1.5	0.2	-0.2	-0.2	-1.2
Pack years of smoking	0.4	0.6	1.1	-1.0	0.4	-0.4	-1.1
Impedance of whole body	1.8	9.0	20.1	-4.5	2.7	-2.9	0.0
Leg fat mass (left)	0.8	2.9	5.0	2.0	-2.2	1.7	0.0
Arm predicted mass (left)	2.2	11.0	15.5	3.9	-3.9	3.7	-0.3