Hub : Genes

DDX1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1380 0.0400 3.2e-04 0.100 NA 0.089 NA 0.104 1.4e-08 NA 1.0e-07 NA 7.6e-09
2 GTEx Adipose Visceral Omentum 0.2350 0.0680 7.4e-04 0.074 NA 0.043 NA 0.055 1.1e-04 NA 2.8e-03 NA 8.3e-04
3 GTEx Artery Aorta 0.3360 0.0650 5.0e-08 0.201 NA 0.134 NA 0.175 2.6e-11 NA 8.0e-08 NA 6.0e-10
4 GTEx Artery Tibial 0.2461 0.0498 1.7e-08 0.183 NA 0.178 NA 0.187 2.7e-14 NA 6.4e-14 NA 1.4e-14
5 GTEx Cells EBV-transformed lymphocytes 0.3870 0.0780 1.5e-06 0.275 NA 0.205 NA 0.226 1.5e-09 NA 2.9e-07 NA 6.4e-08
6 GTEx Cells Transformed fibroblasts 0.5700 0.0470 0.0e+00 0.540 NA 0.528 NA 0.529 1.6e-47 NA 5.0e-46 NA 4.5e-46
7 GTEx Heart Atrial Appendage 0.2020 0.0670 2.6e-03 0.065 NA 0.074 NA 0.062 7.0e-04 NA 3.1e-04 NA 9.0e-04
8 GTEx Heart Left Ventricle 0.2798 0.0610 4.4e-06 0.215 NA 0.207 NA 0.218 1.1e-11 NA 2.7e-11 NA 7.5e-12
9 GTEx Lung 0.1455 0.0412 4.5e-05 0.086 NA 0.075 NA 0.088 4.1e-07 NA 2.2e-06 NA 2.9e-07
10 GTEx Nerve Tibial 0.1835 0.0500 7.2e-05 0.078 NA 0.107 NA 0.097 3.3e-06 NA 5.3e-08 NA 2.1e-07
11 GTEx Pancreas 0.4360 0.0710 1.6e-08 0.321 NA 0.283 NA 0.340 3.5e-14 NA 2.0e-12 NA 4.5e-15
12 GTEx Skin Sun Exposed Lower leg 0.0950 0.0340 1.9e-03 0.023 NA 0.008 NA 0.024 4.9e-03 NA 6.6e-02 NA 3.8e-03
13 YFS Blood 0.0508 0.0146 8.1e-08 0.040 0.023 0.034 0.037 0.039 3.7e-13 2.9e-08 1.9e-11 3.2e-12 9.0e-13
14 TCGA Breast Invasive Carcinoma 0.0609 0.0204 1.5e-15 0.076 0.080 0.084 NA 0.085 3.3e-15 4.2e-16 9.5e-17 NA 4.9e-17
15 TCGA Colon Adenocarcinoma 0.0990 0.0530 5.5e-04 0.087 0.066 0.051 NA 0.076 9.5e-06 1.1e-04 6.2e-04 NA 3.5e-05
16 TCGA Head and Neck Squamous Cell Carcinoma 0.0602 0.0421 1.6e-03 0.002 0.014 0.007 NA 0.005 1.8e-01 9.4e-03 5.2e-02 NA 7.5e-02
17 TCGA Kidney Renal Clear Cell Carcinoma 0.0695 0.0328 1.3e-05 0.034 0.049 0.033 NA 0.039 8.2e-05 3.1e-06 1.2e-04 NA 2.9e-05
18 TCGA Brain Lower Grade Glioma 0.0328 0.0165 6.6e-04 0.041 0.023 0.031 NA 0.033 1.9e-05 1.1e-03 1.6e-04 NA 1.1e-04
19 TCGA Lung Adenocarcinoma 0.1357 0.0516 5.3e-09 0.077 0.072 0.062 NA 0.073 2.5e-09 8.5e-09 8.5e-08 NA 6.8e-09
20 TCGA Lung Squamous Cell Carcinoma 0.0420 0.0219 2.7e-04 0.029 0.041 0.030 NA 0.024 2.5e-04 1.8e-05 2.0e-04 NA 7.6e-04
21 TCGA Pancreatic Adenocarcinoma 0.1900 0.0910 1.5e-04 0.032 0.087 0.104 NA 0.052 1.7e-02 1.7e-04 4.2e-05 NA 3.0e-03
22 TCGA Prostate Adenocarcinoma 0.0854 0.0324 2.6e-09 0.096 0.083 0.089 NA 0.092 3.2e-10 5.4e-09 1.3e-09 NA 6.7e-10
23 TCGA Stomach Adenocarcinoma 0.0640 0.0340 1.1e-03 0.034 0.044 0.029 NA 0.041 1.7e-03 3.8e-04 3.4e-03 NA 5.6e-04
24 TCGA Thyroid Carcinoma 0.0440 0.0300 9.3e-03 -0.001 0.002 -0.003 NA -0.001 4.1e-01 2.1e-01 1.0e+00 NA 4.7e-01
25 TCGA Uterine Corpus Endometrial Carcinoma 0.1380 0.0740 7.0e-03 0.114 0.088 0.097 NA 0.122 4.6e-04 2.0e-03 1.2e-03 NA 2.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Bipolar Disorder (2018) 0.2 0.3 2.3 0.2 0.4 0.4 0.3 0.1 0.2 0.4 -0.6 0.5 0.5 0.6 -0.0 -0.5 0.1 0.6 1.1 0.3 -0.3 0.3 0.5 1.5 0.0 0.3 -0.3 -0.3
Bipolar Disorder or Schizophrenia 0.2 0.5 3.5 0.6 0.7 0.7 0.6 0.6 0.6 -0.3 -0.7 0.6 0.6 0.7 0.4 -0.8 0.6 1.1 0.0 0.8 0.6 0.9 0.1 1.9 0.7 1.0 0.0 0.5
Depressed Affect (Nagel 2018) 0.4 0.8 3.2 0.7 1.2 1.0 0.7 0.6 0.5 -1.2 -1.0 0.8 0.4 1.4 0.5 -1.1 0.8 1.0 0.5 0.8 0.1 0.9 -0.0 1.8 1.0 1.2 0.2 0.4
Depression (Nagel 2018) 2.6 3.9 5.8 2.4 2.1 2.3 2.3 2.4 2.4 -1.0 -2.1 2.3 1.7 2.4 1.5 -2.3 2.0 2.2 1.2 2.3 1.2 2.2 1.4 2.1 2.0 1.9 1.3 1.2
Intelligence (Savage-Jansen 2018) 0.1 0.5 1.0 0.9 0.8 0.5 0.8 0.9 0.9 0.8 -0.8 0.7 0.9 0.4 0.6 -0.2 0.6 0.7 0.6 0.5 0.4 0.7 1.0 0.1 0.6 0.3 0.6 0.4
Neuroticism (Nagel 2018) 0.1 0.4 1.6 0.5 0.7 0.7 0.4 0.4 0.4 -0.9 -0.5 0.6 0.1 0.7 0.4 -0.3 0.6 0.7 0.7 0.4 0.3 0.4 -0.1 1.3 0.7 0.9 0.3 0.5
Schizophrenia (2018) 0.3 0.5 1.4 0.6 0.6 0.5 0.5 0.6 0.6 -0.8 -0.4 0.5 0.3 0.5 0.6 -0.7 0.7 1.0 -0.9 0.9 1.0 1.0 -0.2 1.2 0.8 1.0 0.3 0.9
Schizophrenia vs Biploar Disorder 0.9 1.2 5.2 -0.7 -0.7 -1.2 -1.1 -0.7 -0.9 -0.4 0.9 -1.0 -2.0 -1.2 -1.1 1.0 -0.8 -1.1 -2.2 -0.7 -0.1 -1.1 -2.3 -0.5 -0.7 -0.6 -0.9 -0.2
Worry (Nagel 2018) 0.3 0.6 1.6 0.3 0.8 0.7 0.4 0.3 0.3 -0.5 -0.5 0.6 0.2 0.7 1.0 -0.3 1.0 0.5 1.2 0.6 1.3 0.3 0.0 1.0 0.9 1.2 1.1 1.2
Alzheimer’s Disease (in mother) 0.3 0.4 1.3 0.6 0.7 0.5 0.4 0.7 0.6 -1.1 -0.6 0.8 0.2 0.5 -0.7 -0.6 -0.0 0.8 0.6 0.6 -0.8 0.5 -0.3 0.9 -0.1 0.2 -0.4 -1.1
Alzheimer’s Disease (in father) 0.2 0.3 1.4 -0.0 0.3 0.2 -0.2 -0.0 -0.1 -0.9 -0.3 0.2 -0.6 0.5 -0.9 -0.4 -0.5 0.1 -0.1 -0.1 -1.2 -0.1 -0.8 -0.0 -0.3 -0.3 -0.6 -1.0
Alzheimer’s Disease (including proxy) 0.4 0.6 2.8 0.4 0.6 0.3 0.1 0.4 0.3 -1.6 -0.5 0.7 -0.3 0.6 -1.3 -0.6 -0.4 0.5 0.1 0.4 -1.5 0.4 -0.8 0.4 -0.4 -0.3 -0.8 -1.7
Crohns Disease (2017) 0.1 0.2 1.4 0.1 0.2 0.5 0.3 0.1 0.1 0.2 -0.2 0.2 0.4 0.5 0.3 -0.4 0.3 0.4 0.6 0.6 -0.1 0.5 0.2 1.2 0.3 0.5 0.1 0.2
Irritable Bowel Disease (IBD) 0.8 1.8 6.4 1.2 1.1 1.7 1.4 1.2 1.2 -0.0 -1.2 1.3 1.6 1.1 1.3 -1.3 1.4 1.4 1.3 1.5 0.7 1.5 1.4 2.5 1.4 1.6 0.8 1.0
Ulcerative Colitis (UC) 0.9 1.6 4.5 1.3 1.1 1.5 1.4 1.4 1.4 0.2 -1.3 1.4 1.6 1.1 1.1 -1.2 1.2 1.4 0.9 1.5 0.6 1.6 1.4 2.1 1.2 1.3 0.7 0.8
Major Depression (MDD) 1.9 2.3 7.5 1.9 1.9 1.7 1.5 1.8 1.7 -2.7 -1.7 1.9 0.3 2.1 -0.4 -2.4 0.9 1.8 0.9 1.7 -0.9 1.8 0.2 0.8 1.1 1.0 0.5 -0.7
Reaction Time 0.2 0.3 0.9 0.5 0.7 0.2 0.5 0.5 0.5 0.6 -0.5 0.3 0.6 -0.0 0.5 -0.4 0.5 0.6 -0.7 0.4 0.8 0.6 0.2 0.9 0.5 0.4 -0.1 0.8
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.8 1.1 1.1 0.8 1.1 1.1 1.1 -0.1 -1.0 0.9 1.1 0.6 1.2 -0.4 1.1 0.8 0.7 0.9 1.0 1.0 1.2 0.1 1.1 0.8 1.3 1.1
Breast Cancer 0.3 0.6 3.7 0.2 0.3 0.1 -0.1 0.3 0.2 -1.9 -0.2 0.3 -0.9 -0.1 0.4 0.1 0.7 -0.0 -0.9 -0.0 1.9 -0.6 -0.9 0.0 0.5 1.1 0.8 1.6
Ovarian Cancer 1.8 2.3 6.3 1.2 1.5 1.4 1.3 1.2 1.2 -1.4 -1.3 1.2 1.3 1.2 2.1 -1.2 1.9 1.0 1.0 1.5 2.5 1.0 0.9 1.0 1.8 2.0 2.2 2.5
Prostate Cancer 0.4 0.6 2.5 0.6 0.5 0.8 0.6 0.8 0.7 0.2 -0.6 0.6 0.9 0.8 0.5 -0.5 0.7 0.8 1.1 1.0 0.6 0.8 0.5 -0.6 0.6 0.7 1.6 0.5
Age at First Birth 0.6 0.9 1.8 1.2 1.0 1.2 1.1 1.3 1.2 -0.7 -1.3 1.3 0.7 0.8 0.4 -0.8 1.0 1.0 1.4 0.9 0.7 0.7 0.6 0.5 0.8 1.0 0.9 0.4
Bipolar Disorder (2011) 0.5 0.5 1.2 0.8 0.9 0.7 0.7 0.8 0.7 -0.1 -0.9 0.9 0.7 0.8 0.0 -0.9 0.4 1.1 0.7 0.9 -0.4 0.9 0.2 0.8 0.6 0.7 0.4 -0.0
Body Mass Index (BMI) (2010) 1.0 1.4 2.0 1.2 1.1 1.4 1.3 1.2 1.2 -1.2 -1.1 1.2 1.0 1.3 1.2 -1.4 1.2 1.3 1.0 1.3 0.7 1.4 1.2 0.9 1.2 1.2 1.1 0.8
Coronary Artery Disease (CAD) 0.4 0.4 1.1 -0.7 -0.8 -0.6 -0.7 -0.7 -0.7 0.3 0.7 -0.6 -0.4 -0.8 -0.7 0.7 -0.9 -0.4 -0.9 -0.3 -1.0 -0.3 -1.1 -0.4 -0.7 -0.5 -0.3 -0.4
Crohns Disease (2012) 0.7 1.2 2.7 0.7 0.8 0.9 1.0 0.8 0.8 -0.8 -0.7 0.7 0.9 0.7 1.4 -0.7 1.3 0.8 1.0 1.1 1.5 0.7 0.8 1.6 1.2 1.6 1.3 1.5
Mean Putamen Volume 1.5 1.7 5.1 1.3 1.3 1.5 1.2 1.4 1.4 -1.2 -1.4 1.6 0.9 1.0 0.8 -1.4 1.2 1.6 0.7 1.6 0.8 1.3 0.2 2.3 1.2 1.8 0.8 0.8
Fasting Glucose 1.3 1.6 3.4 1.1 -1.1 -1.6 0.2 1.2 1.4 1.1 1.2 0.1 -0.7 -1.8 -1.5 1.4 -1.7 -0.7 -1.0 -1.1 -1.3 -1.9 -1.3 -1.4 -1.3 -1.3 -1.3 -1.2
HbA1C 0.1 0.1 0.5 0.4 0.3 0.1 0.3 0.4 0.4 -0.5 -0.1 0.4 0.2 -0.0 0.0 0.0 0.1 0.4 -0.2 0.3 0.3 0.0 -0.0 0.7 0.0 0.4 -0.2 0.0
HDL Cholesterol 0.7 1.1 2.3 -1.2 -1.3 -1.3 -1.1 -1.2 -1.2 0.9 1.4 -1.1 -1.0 -1.1 -0.6 1.1 -1.0 -1.2 0.3 -1.2 -0.6 -1.5 -0.7 -0.7 -0.9 -0.8 -0.6 -0.6
LDL Cholesterol 1.0 1.6 3.7 1.3 1.4 1.3 1.4 1.2 1.3 -1.1 -1.4 1.2 1.4 1.9 1.1 -1.4 1.3 1.3 1.2 1.2 0.8 1.4 1.3 1.3 1.3 1.2 0.9 0.8
Lupus 1.4 2.1 3.2 1.6 1.4 1.2 1.5 1.6 1.6 -1.7 -1.4 1.5 1.7 1.2 1.7 -0.8 1.6 1.3 1.3 1.5 1.6 1.3 1.3 0.4 1.6 1.4 1.8 1.6
Neuroticism (2016) 2.3 3.3 4.9 -2.1 -1.6 -1.9 -2.0 -2.1 -2.0 1.2 1.9 -1.9 -1.8 -2.2 -1.5 2.1 -2.0 -1.8 -1.4 -2.0 -1.5 -2.2 -1.8 -1.2 -1.9 -1.6 -1.5 -1.2
Primary Biliary Cirrhosis 2.1 3.0 8.5 1.7 1.5 1.8 1.8 1.7 1.7 -1.2 -1.6 1.7 2.1 1.6 1.4 -1.5 1.6 2.4 1.4 1.9 0.7 2.4 2.0 2.9 1.6 1.6 0.8 0.7
Rheumatoid Arthritis 0.2 0.3 1.3 0.6 0.8 0.6 0.6 0.5 0.5 -1.1 -0.6 0.6 0.3 0.7 0.2 -0.5 0.3 0.2 1.1 0.4 -0.3 0.2 0.6 -0.2 0.3 0.3 0.5 -0.2
Schizophrenia (2014) 0.1 0.2 2.1 -0.2 -0.3 -0.1 -0.3 -0.2 -0.3 -0.3 0.4 -0.3 -0.4 -0.3 0.2 0.3 0.2 0.2 -1.4 0.1 0.8 0.2 -0.6 1.1 0.1 0.4 -0.3 0.7
Triglycerides 0.8 1.3 4.1 0.9 0.8 1.0 0.8 0.8 0.9 -1.2 -0.8 0.9 0.6 1.0 1.5 -0.7 1.4 0.7 -0.1 1.0 2.0 0.6 0.0 1.7 1.4 1.6 1.1 2.0
Type 2 Diabetes (T2D) (2012) 0.6 0.7 3.1 0.3 0.7 0.6 0.6 0.4 0.5 -0.6 -0.5 0.3 0.8 0.6 1.3 -0.0 0.9 0.8 0.1 0.8 1.7 0.3 0.6 1.2 0.8 1.2 1.0 1.8
Ulcerative Colitis 0.5 0.7 2.3 0.7 0.7 1.0 0.8 0.7 0.7 0.1 -0.8 0.8 1.1 0.5 0.9 -0.9 0.9 1.0 0.1 1.0 0.7 1.2 0.8 1.5 0.9 0.9 0.4 0.8
Blood Eosinophil Count 0.7 5.7 7.1 -2.6 -2.4 -2.5 -2.6 -2.6 -2.7 0.1 2.5 -2.4 -2.5 -2.1 -2.6 2.0 -2.6 -2.3 -2.6 -2.4 -2.3 -2.2 -2.5 -2.2 -2.5 -2.6 -2.4 -2.1
Blood Platelet Count 0.2 2.2 13.5 -0.5 -0.3 -0.8 -0.8 -0.4 -0.6 -0.2 0.4 -0.6 -1.0 -0.9 -2.8 0.4 -2.0 0.1 -0.2 -0.7 -3.7 -0.3 -0.8 -1.1 -1.8 -1.7 -1.9 -3.5
Blood Red Count 0.1 1.4 7.8 0.4 0.5 0.3 0.7 0.4 0.6 0.8 -0.4 0.4 1.2 -0.2 2.3 0.2 1.3 0.1 0.9 0.3 2.8 -0.1 0.7 2.2 1.0 1.3 0.9 2.5
Blood White Count 0.1 0.6 1.6 0.8 1.3 0.8 0.8 0.8 0.7 -0.5 -1.1 0.7 0.5 0.7 0.6 -1.1 0.8 0.4 0.1 0.8 0.5 0.5 -0.1 1.2 0.9 0.8 0.3 0.7
Heel T-Score 1.9 15.1 34.1 3.2 3.2 3.6 3.6 3.1 3.3 -0.3 -3.4 3.3 3.8 3.4 5.2 -3.6 4.8 3.1 3.1 3.7 5.3 3.2 2.5 3.9 4.9 4.8 4.9 5.8
BMI 0.2 1.4 7.3 0.6 0.8 1.1 0.6 0.5 0.5 0.0 -0.8 0.6 0.1 0.9 1.5 -1.5 1.3 0.4 -1.1 0.9 1.7 0.6 -0.9 2.7 1.5 1.4 0.2 2.3
Height 0.6 11.4 15.4 3.8 3.8 3.7 3.7 3.9 3.9 -3.2 -3.9 3.9 3.5 3.8 2.6 -3.6 3.1 3.7 3.7 3.5 1.8 3.4 3.2 2.1 3.2 3.1 2.9 2.0
Waist Hip Ratio (WHR) 0.2 0.7 7.3 0.4 1.1 0.2 0.0 0.4 0.2 -2.7 -0.7 0.3 -0.6 0.0 -1.2 -0.5 -0.3 0.4 0.8 0.2 -1.0 -0.2 -0.9 0.2 -0.3 0.1 -0.6 -1.6
Systolic Blood Pressure 0.2 1.2 4.2 -0.8 -0.9 -1.1 -1.2 -0.8 -0.9 -0.7 1.1 -1.1 -1.6 -1.0 -1.4 0.7 -1.2 -0.7 -2.1 -0.7 -0.6 -1.0 -2.0 -1.0 -1.1 -0.7 -0.7 -0.6
Smoking Status 1.5 3.6 4.7 2.0 2.2 1.8 2.1 2.0 2.0 -1.3 -2.0 2.0 2.0 2.1 1.8 -2.2 1.9 2.0 1.5 2.0 1.5 2.2 2.0 1.5 1.9 1.8 1.6 1.3
Allergy or Eczema 0.1 0.3 1.2 -0.3 -0.0 -0.5 -0.4 -0.3 -0.3 -0.1 0.3 -0.3 -0.8 -0.1 -0.1 0.3 0.0 -0.8 -0.5 -0.6 0.6 -1.0 -0.8 -1.1 -0.0 0.1 0.3 0.4
Cardiovascular Disease 0.2 0.5 1.3 -0.5 -0.0 -0.5 -0.6 -0.5 -0.6 -0.9 0.3 -0.5 -1.0 0.0 -1.1 0.1 -0.8 -0.4 -1.1 -0.6 -1.1 -0.4 -1.1 -0.2 -0.7 -0.7 -1.1 -1.0
Hypothyroidism (self reported) 0.8 1.9 8.6 1.3 1.4 1.4 1.3 1.3 1.3 -2.9 -1.4 1.4 1.1 1.4 0.8 -1.3 1.0 1.5 1.4 1.7 0.2 1.5 0.8 1.4 1.2 1.4 1.1 0.6
Respiratory disease 0.1 0.2 1.2 -0.3 -0.1 -0.4 -0.3 -0.3 -0.3 -0.3 0.4 -0.4 -0.7 -0.8 -0.1 0.6 -0.1 -0.9 0.3 -0.6 0.5 -1.1 -0.2 -0.2 -0.3 -0.0 0.0 -0.0
Type 2 Diabetes (T2D) (2018) 0.1 0.3 1.7 -0.1 -0.2 0.2 0.2 -0.1 0.0 0.7 0.2 -0.1 0.3 0.2 1.1 0.1 0.4 -0.2 0.2 -0.0 1.0 -0.0 0.8 0.4 0.4 0.3 0.5 1.3
Lung FEV1/FVC ratio 0.1 0.5 7.3 0.2 0.0 0.3 0.3 0.3 0.2 -2.7 0.2 -0.0 0.6 0.1 0.7 -0.4 0.3 0.4 -0.9 0.6 0.4 0.8 0.8 0.4 0.4 0.2 -0.1 0.6
Lung FVC 0.1 0.6 5.5 -0.3 -0.2 -0.3 -0.5 -0.2 -0.3 -2.3 0.1 -0.1 -0.5 -0.6 -1.4 0.3 -0.7 0.1 0.0 -0.1 -0.9 -0.3 -1.0 0.6 -0.9 -0.3 -0.8 -1.4
Neuroticism 0.4 1.1 2.6 0.9 1.2 1.0 1.0 0.8 0.8 -1.1 -0.9 1.0 0.6 1.6 0.9 -0.9 1.0 1.1 1.6 0.9 0.7 0.7 0.5 1.4 1.1 1.4 1.0 0.7
Chronotype (morning person) 0.1 0.2 1.2 -0.3 -0.6 0.2 0.0 -0.4 -0.2 -0.1 0.4 -0.0 0.4 0.3 0.2 0.2 -0.1 -0.3 1.1 -0.2 -0.4 -0.2 0.9 0.5 -0.3 -0.0 -0.3 -0.5
Hair Pigment 0.0 0.8 2.4 0.7 1.0 1.2 0.7 0.8 0.7 -0.6 -1.3 0.9 1.1 1.2 0.5 -1.2 0.6 1.3 -0.1 1.2 -0.0 1.6 0.8 0.8 0.8 0.7 0.4 0.4
Tanning 0.1 0.7 2.2 -1.1 -0.7 -0.8 -0.8 -1.1 -1.0 1.1 0.7 -0.9 -0.1 -0.6 -0.5 0.9 -0.8 -0.8 0.5 -0.9 -0.3 -1.0 0.1 -1.5 -1.0 -0.8 -0.3 -0.8
Hand grip strength (left) 0.3 0.9 3.8 0.7 0.8 0.4 0.5 0.7 0.7 -1.6 -0.6 0.6 0.1 0.6 1.0 -0.5 1.1 0.5 -0.5 0.9 1.9 0.5 -0.6 0.8 1.1 1.2 1.3 1.9
Number of treatments/medications taken 0.1 0.1 0.7 0.1 0.3 0.3 0.2 0.1 0.1 -0.1 -0.2 0.2 -0.2 0.7 -0.1 -0.7 0.1 0.2 -0.0 0.4 -0.5 0.4 -0.2 0.8 0.2 0.2 0.0 -0.2
Average weekly spirits intake 2.7 3.4 6.3 -2.2 -1.7 -2.0 -2.1 -2.1 -2.2 1.6 1.8 -2.1 -2.0 -2.0 -1.5 2.0 -1.8 -1.8 -1.4 -2.1 -1.1 -2.3 -2.5 -0.5 -1.7 -1.3 -1.7 -0.8
Sensitivity / hurt feelings 0.1 0.2 0.7 -0.5 -0.3 -0.3 -0.3 -0.5 -0.5 0.9 0.5 -0.3 -0.3 0.0 0.4 0.4 0.2 -0.5 0.6 -0.5 0.7 -0.8 -0.5 0.3 0.2 0.3 0.4 0.7
Frequency of depressed mood in last 2 weeks 5.2 7.3 12.4 3.3 3.4 3.0 2.9 3.3 3.2 -2.3 -3.2 3.2 2.0 3.4 1.4 -3.5 2.6 3.1 1.5 3.0 1.4 2.9 1.0 3.0 2.7 2.6 1.6 1.3
Hearing difficulty/problems: Yes 0.5 0.7 6.2 0.7 0.5 1.0 0.7 0.8 0.8 -0.7 -0.5 0.8 0.2 0.8 0.8 -0.8 0.8 0.6 0.1 0.8 0.6 0.7 0.3 2.5 0.8 0.9 -0.1 0.8
Relative age of first facial hair 1.0 2.0 5.0 -1.2 -1.2 -1.5 -1.4 -1.3 -1.2 0.3 1.5 -1.2 -1.8 -1.4 -1.6 1.7 -1.4 -1.4 -1.8 -1.6 -1.2 -1.4 -1.3 -2.2 -1.3 -1.5 -1.2 -1.1
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 3.0 -0.7 -0.3 -0.3 -0.6 -0.6 -0.7 -0.4 0.2 -0.6 -0.1 0.1 -1.3 0.4 -1.0 0.3 -0.7 -0.5 -1.5 0.2 -0.1 -0.1 -1.1 -1.1 -1.5 -1.7
Ever used hormone-replacement therapy (HRT) 1.4 1.7 6.0 -1.2 -1.1 -0.9 -0.9 -1.2 -1.2 2.0 1.1 -1.2 -0.3 -0.8 -1.3 1.0 -1.6 -0.9 -0.3 -1.2 -2.4 -0.6 0.5 -1.1 -1.6 -1.8 -1.6 -2.2
Ever had hysterectomy (womb removed) 1.3 1.5 3.8 0.9 0.9 1.1 1.1 0.9 0.9 -0.3 -1.0 0.9 1.0 1.0 1.8 -1.2 1.6 0.9 1.0 1.0 1.9 0.9 1.2 0.5 1.5 1.5 1.8 2.0
Systolic blood pressure, automated reading 0.3 0.9 2.1 -0.7 -0.6 -0.7 -0.9 -0.7 -0.7 0.7 0.8 -0.9 -0.9 -0.9 -1.4 0.3 -1.1 -0.8 -1.2 -0.6 -1.1 -1.0 -1.4 -0.4 -1.1 -0.8 -1.2 -1.3
Eye problems/disorders: Diabetes related eye disease 2.6 2.9 4.1 1.9 1.6 2.0 1.8 1.9 1.9 -1.5 -1.6 2.0 1.2 1.8 1.4 -1.9 1.7 1.6 2.0 1.8 1.0 1.5 1.2 1.9 1.7 1.9 1.5 1.3
Angina 0.1 0.1 0.6 -0.1 0.2 0.3 0.1 -0.1 -0.1 0.3 -0.2 -0.0 0.6 0.1 -0.1 -0.1 -0.2 -0.1 0.8 -0.1 -0.6 -0.1 0.7 -0.1 -0.2 -0.2 -0.2 -0.5
Medication for hormone replacement therapy 0.3 0.4 2.6 0.3 0.2 0.7 0.6 0.3 0.4 1.6 -0.4 0.4 0.9 0.4 0.5 -0.7 0.1 0.6 0.5 0.5 -0.5 0.7 0.6 1.3 0.4 0.1 -0.2 0.1
Vitamin and mineral supplements 0.4 0.6 1.8 -0.6 -1.1 -0.8 -0.6 -0.7 -0.6 0.2 0.9 -0.7 -0.7 -0.5 -0.7 1.1 -0.7 -0.9 -0.4 -0.8 -0.5 -0.6 -0.3 -1.3 -0.8 -1.0 -0.6 -0.9
Supplements: Zinc 0.5 0.5 3.3 0.7 0.3 0.4 0.6 0.8 0.7 0.8 -0.4 0.6 0.6 -0.3 0.9 -0.4 1.0 0.3 -0.5 0.6 1.8 0.5 0.3 0.4 0.7 0.7 0.8 1.3
Medication: Co-codamol 0.2 0.2 1.3 0.1 -0.3 0.0 -0.0 0.1 0.0 0.0 0.4 0.1 -0.2 -0.1 -0.8 -0.4 -0.4 -0.1 -0.7 0.0 -1.1 0.1 -0.6 0.7 -0.3 -0.3 -1.0 -1.0
Medication: Metformin 0.1 0.1 0.3 -0.3 -0.4 -0.2 -0.2 -0.4 -0.3 0.0 0.5 -0.3 -0.4 0.0 0.2 0.1 -0.1 -0.3 -0.1 -0.2 0.3 -0.3 -0.0 0.3 -0.1 0.2 0.1 0.3
Diabetes (father) 0.4 0.5 2.9 -0.6 -1.0 -0.3 -0.7 -0.6 -0.6 0.3 0.9 -0.4 -0.7 -0.6 -0.5 0.2 -0.4 -0.2 -1.7 -0.3 -0.1 -0.3 -1.2 1.1 -0.4 -0.1 -1.0 0.1
Diabetes (mother) 5.8 7.4 10.3 2.5 2.2 2.9 2.7 2.5 2.5 -1.7 -2.3 2.6 2.8 2.8 3.2 -2.7 3.2 2.7 1.9 2.9 3.0 2.9 2.4 2.9 3.1 3.1 2.6 3.0
Severe depression (siblings) 0.4 0.5 4.0 0.0 0.4 0.0 0.0 0.0 0.0 -0.8 -0.1 0.1 -0.5 -0.2 1.0 0.2 0.8 -0.2 -0.3 0.1 2.0 -0.2 -0.2 0.2 0.6 0.8 1.0 1.7
Pack years adult smoking proportion 1.5 2.3 6.1 1.6 1.8 1.7 1.6 1.6 1.6 -2.5 -1.7 1.7 1.0 2.0 1.0 -1.9 1.3 1.5 1.5 1.5 0.3 1.4 1.1 0.7 1.5 1.4 1.2 0.7
Impedance of leg (right) 0.6 2.8 16.3 -0.8 -0.4 -1.4 -0.9 -0.8 -0.8 1.1 0.6 -0.9 -0.5 -1.2 -2.7 1.2 -2.3 -0.7 0.9 -1.3 -3.6 -1.1 -0.1 -0.9 -2.3 -2.0 -2.2 -4.0
Leg fat-free mass (left) 0.6 3.4 7.5 1.7 1.6 2.0 1.6 1.7 1.7 -1.6 -1.7 1.8 0.9 2.1 2.0 -2.3 2.2 1.4 0.0 2.0 2.2 1.6 0.1 2.3 2.3 2.2 1.4 2.7
Trunk fat percentage 0.2 0.8 6.9 0.7 1.2 1.1 0.8 0.6 0.6 -0.0 -1.0 0.7 0.4 0.7 0.5 -1.3 0.9 0.5 0.5 0.8 0.2 0.5 -0.2 2.6 0.9 1.0 -0.4 0.3
Hand grip strength (right) 0.3 0.9 4.2 0.5 0.4 0.3 0.4 0.5 0.5 -1.4 -0.3 0.5 0.2 0.6 1.2 -0.6 1.1 0.5 -0.2 0.8 2.0 0.4 -0.6 0.5 1.2 1.3 1.5 2.1
Townsend deprivation index at recruitment 2.4 3.3 8.0 2.1 2.1 2.1 1.9 2.1 2.0 -1.4 -2.0 1.9 1.7 1.8 1.3 -2.3 1.7 2.1 0.4 2.1 0.9 2.2 1.0 2.8 1.8 1.8 0.4 1.0
Current tobacco smoking 0.8 1.3 3.1 1.4 1.8 1.1 1.3 1.4 1.4 -1.3 -1.5 1.4 1.4 1.2 0.4 -1.3 0.9 1.4 1.1 1.1 0.2 1.2 1.4 0.7 0.8 0.8 0.4 -0.2
Average weekly fortified wine intake 0.4 0.5 1.0 0.8 0.9 0.5 0.6 0.7 0.7 0.7 -0.8 0.7 0.3 0.3 0.7 -0.6 0.8 0.2 1.0 0.5 1.0 0.1 -0.1 0.8 0.8 0.7 0.9 0.8
Maternal smoking around birth 0.2 0.3 1.9 -0.2 -0.3 -0.3 -0.3 -0.2 -0.2 0.6 0.1 -0.2 0.2 -0.1 -1.0 -0.1 -0.8 -0.1 -0.3 -0.3 -1.4 -0.2 -0.4 -0.1 -0.7 -0.7 -1.1 -1.2
Fed-up feelings 0.5 0.9 5.7 0.5 1.1 0.7 0.3 0.5 0.4 -2.4 -0.7 0.6 -0.5 0.8 0.5 -0.7 0.9 0.4 -0.3 0.7 1.1 0.0 -1.3 1.9 1.0 1.6 0.4 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.6 4.8 7.7 2.7 2.5 2.3 2.4 2.7 2.7 -1.8 -2.5 2.5 1.5 2.5 1.4 -2.8 2.0 2.6 1.0 2.5 1.1 2.4 1.0 2.5 2.3 2.2 1.4 1.4
Relative age voice broke 0.3 0.4 1.3 -0.4 -0.3 -0.5 -0.5 -0.4 -0.4 -0.6 0.4 -0.3 -0.3 -0.6 -0.9 0.7 -0.8 0.1 -0.5 -0.5 -1.1 -0.1 0.2 -1.0 -0.8 -0.7 -0.6 -1.1
Taking other prescription medications 0.5 0.8 1.9 -1.2 -0.7 -0.9 -1.1 -1.1 -1.1 0.1 0.8 -0.9 -1.4 -0.6 -0.8 0.8 -0.8 -0.9 -0.6 -0.9 -0.5 -1.1 -1.3 0.6 -0.9 -0.5 -0.9 -0.6
Age when periods started (menarche) 0.0 0.1 0.4 0.5 0.1 -0.0 0.4 0.5 0.5 0.6 -0.1 0.4 0.4 -0.1 0.2 -0.2 0.0 0.1 0.5 0.0 0.1 0.1 0.7 0.1 0.0 -0.3 -0.0 -0.1
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 2.1 -1.4 -1.3 -1.1 -1.3 -1.4 -1.4 0.5 1.2 -1.3 -1.0 -1.2 -0.9 1.0 -1.0 -1.1 -1.2 -1.0 -0.5 -0.9 -1.0 -1.5 -1.0 -1.1 -0.5 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.5 8.8 1.8 2.2 2.0 1.9 1.7 1.8 -1.6 -2.0 1.9 1.8 2.0 2.5 -2.1 2.4 1.9 2.2 2.2 2.1 1.7 0.9 2.1 2.7 2.7 2.7 3.0
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.9 1.2 1.0 1.0 1.0 1.1 1.1 -0.6 -1.1 1.2 0.6 1.3 0.6 -1.1 1.0 0.5 0.1 1.0 0.6 0.7 -0.1 1.4 1.0 0.9 0.4 0.6
Qualifications: CSEs or equivalent 0.4 0.5 2.2 0.5 0.6 0.4 0.6 0.5 0.6 -0.2 -0.4 0.5 0.7 0.2 1.1 -0.7 0.8 0.3 0.3 0.5 1.5 0.2 0.7 1.0 0.7 1.0 0.8 1.3
Serious illness, injury or assault to yourself 0.9 1.1 2.9 1.1 1.4 1.1 1.0 1.1 1.0 -0.6 -1.4 1.1 1.0 1.7 0.4 -1.5 0.7 1.5 0.7 1.3 -0.1 1.5 0.6 0.6 0.8 0.8 0.9 0.1
High blood pressure 0.7 1.9 5.0 -1.1 -0.7 -1.1 -1.3 -1.1 -1.2 -0.2 0.9 -1.0 -1.8 -0.7 -2.2 0.7 -1.6 -0.9 -1.5 -1.1 -2.1 -1.0 -2.0 -0.9 -1.5 -1.4 -1.8 -2.1
Hayfever, allergic rhinitis or eczema 0.2 0.3 1.8 -0.4 0.0 -0.6 -0.5 -0.4 -0.4 -1.1 0.3 -0.3 -1.2 0.2 -0.5 0.1 -0.2 -0.6 -0.8 -0.5 0.0 -0.6 -0.9 -1.4 -0.2 -0.2 0.0 -0.1
Multivitamins +/- minerals 0.1 0.1 0.6 -0.3 0.3 -0.1 -0.2 -0.2 -0.3 0.4 -0.2 -0.3 0.3 -0.5 0.1 0.0 -0.0 0.3 -0.8 -0.0 0.3 0.0 -0.1 0.8 -0.1 0.2 -0.2 0.5
Stomach or abdominal pain in last month 0.1 0.1 0.5 -0.2 -0.1 -0.2 -0.3 -0.2 -0.2 -0.6 0.3 -0.3 -0.7 -0.2 0.0 0.1 0.0 -0.4 -0.2 -0.2 0.5 -0.5 -0.7 -0.2 0.0 0.2 0.4 0.5
Supplements: Glucosamine 0.2 0.2 1.1 0.1 0.3 0.3 0.1 0.2 0.0 -1.0 -0.5 0.2 0.2 0.3 -0.1 -0.2 0.2 0.5 1.0 0.4 -0.1 0.3 0.3 -0.8 0.1 0.4 0.9 -0.3
Diverticular disease/diverticulitis (self-reported) 1.0 1.1 3.8 -0.5 -0.4 -1.2 -0.9 -0.6 -0.6 -0.2 0.7 -0.7 -1.7 -1.0 -1.5 0.8 -1.1 -1.3 -1.2 -1.0 -1.1 -1.4 -1.9 -1.1 -0.9 -0.9 -1.0 -1.1
Medication: Atenolol 0.2 0.2 1.6 -0.3 -0.4 -0.3 -0.4 -0.3 -0.3 -0.4 0.4 -0.2 -0.5 -0.3 -0.7 0.2 -0.5 0.2 -1.3 0.1 -0.6 0.2 -0.9 0.2 -0.4 -0.3 -0.4 -0.3
Medication: Levothyroxine sodium 0.3 0.5 2.2 0.2 0.5 0.4 0.3 0.2 0.3 -1.5 -0.4 0.4 0.7 0.4 1.0 -0.5 0.7 0.3 0.2 0.6 1.1 0.5 0.5 0.9 0.7 0.9 0.7 1.2
Sitting height 0.4 3.0 6.4 1.6 1.8 1.9 1.8 1.6 1.7 -1.2 -1.9 1.9 1.9 1.8 1.8 -1.9 1.6 1.7 1.8 1.7 1.0 1.5 1.3 2.5 1.8 1.9 1.3 1.6
Chronic bronchitis/emphysema (father) 0.5 0.6 3.6 -0.8 -0.7 -0.8 -0.6 -0.8 -0.7 1.9 0.6 -0.9 -0.1 -0.6 0.2 0.9 -0.3 -1.2 -0.2 -0.9 0.3 -1.2 -0.5 0.9 -0.3 -0.3 -0.6 0.3
High blood pressure (mother) 0.5 0.7 3.2 0.6 0.5 0.6 0.5 0.6 0.6 -1.8 -0.3 0.7 0.1 0.5 1.0 -0.4 1.1 0.5 0.0 0.7 1.7 0.4 0.1 -0.2 1.0 1.2 1.4 1.5
Body mass index (BMI) 0.2 0.7 5.2 0.4 0.6 0.9 0.5 0.3 0.3 -0.4 -0.5 0.4 0.2 0.7 0.9 -1.2 0.9 0.4 -0.7 0.8 0.8 0.6 -0.6 2.3 1.0 1.0 -0.3 1.2
Impedance of leg (left) 0.4 1.8 10.7 -0.5 -0.1 -1.0 -0.6 -0.5 -0.5 0.8 0.3 -0.6 -0.3 -1.0 -2.1 1.0 -1.8 -0.4 1.2 -0.9 -3.0 -0.9 0.1 -0.4 -1.8 -1.4 -1.7 -3.3
Leg predicted mass (left) 0.6 3.4 7.4 1.7 1.6 2.0 1.6 1.7 1.7 -1.5 -1.7 1.8 1.0 2.1 2.0 -2.3 2.1 1.4 0.1 2.0 2.2 1.6 0.1 2.3 2.3 2.2 1.5 2.7
Trunk fat mass 0.5 2.0 9.6 1.3 1.7 1.7 1.4 1.2 1.3 -0.8 -1.6 1.4 0.8 1.5 1.0 -2.0 1.4 1.2 0.8 1.5 0.6 1.1 0.1 3.1 1.5 1.6 0.2 0.9
Waist circumference 0.2 0.6 4.6 0.3 0.8 0.7 0.2 0.3 0.2 -1.1 -0.6 0.4 -0.5 0.5 -0.6 -1.1 -0.0 0.4 -0.4 0.5 -1.0 0.2 -1.2 2.1 0.1 0.4 -1.2 -0.7
Number of incorrect matches in round 0.1 0.2 1.0 -0.3 0.1 -0.3 -0.2 -0.3 -0.3 1.0 0.0 -0.2 -0.4 -0.2 0.2 0.1 -0.1 -0.6 0.1 -0.7 0.1 -0.9 -0.6 1.0 0.0 0.1 -0.5 0.5
Past tobacco smoking 1.6 2.9 5.7 -1.9 -1.7 -1.8 -2.0 -1.9 -1.8 -0.1 1.7 -1.8 -1.8 -2.1 -1.6 2.1 -1.7 -2.0 -0.6 -2.0 -0.8 -2.4 -1.6 -2.0 -1.8 -1.5 -1.1 -1.1
Alcohol usually taken with meals 0.7 1.1 2.8 1.3 1.3 1.1 0.9 1.4 1.2 -0.9 -1.6 1.3 0.4 1.0 0.0 -1.1 0.9 1.7 1.1 1.3 0.5 1.2 -0.1 0.0 1.0 1.1 1.4 0.5
Nervous feelings 0.4 0.8 2.0 0.7 1.0 0.8 0.6 0.7 0.6 -1.4 -0.8 0.8 0.2 0.8 0.8 -0.5 1.1 0.8 0.7 0.7 1.4 0.4 -0.1 1.2 1.0 1.4 1.1 1.1
Frequency of tenseness / restlessness in last 2 weeks 3.8 5.9 11.8 2.9 3.4 2.4 2.4 2.8 2.7 -3.2 -3.1 2.6 1.2 2.8 1.1 -3.0 2.3 2.7 1.9 2.7 1.4 2.0 -0.4 2.1 2.5 2.7 2.3 1.5
Hearing difficulty/problems with background noise 0.9 1.5 4.2 1.2 1.4 1.4 1.2 1.1 1.1 -1.3 -1.3 1.3 0.1 1.9 0.8 -1.6 1.1 1.2 1.0 1.4 0.2 1.2 0.2 2.0 1.4 1.4 0.8 0.8
Hair/balding pattern: Pattern 2 1.8 2.3 4.7 -1.7 -1.4 -1.7 -1.7 -1.7 -1.7 0.6 1.7 -1.7 -1.6 -1.7 -1.2 1.7 -1.5 -1.7 -2.2 -1.6 -0.8 -1.6 -1.7 -1.2 -1.5 -1.5 -1.5 -0.7
Had menopause 0.4 0.5 3.2 0.5 0.6 0.8 0.8 0.5 0.6 0.6 -0.5 0.5 1.4 0.8 0.6 -0.4 0.4 0.4 1.1 0.5 -0.3 0.7 1.8 0.8 0.3 0.3 -0.1 -0.4
Had other major operations 0.1 0.2 1.0 -0.1 -0.2 -0.0 -0.1 -0.2 -0.1 1.0 0.2 -0.1 -0.2 0.4 -0.5 -0.2 -0.3 -0.6 0.3 -0.2 -0.9 -0.2 -0.1 -0.4 -0.2 -0.7 -0.3 -0.7
Forced vital capacity (FVC) 0.4 1.7 6.6 1.2 1.2 1.2 1.1 1.3 1.2 -2.6 -1.2 1.3 1.0 0.9 0.9 -1.2 1.1 1.2 1.2 1.5 1.0 0.8 -0.1 2.1 1.2 1.5 1.2 1.2
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.7 6.8 1.5 1.9 1.9 1.7 1.5 1.5 -1.5 -1.8 1.8 1.7 1.9 2.3 -1.9 2.1 1.7 2.0 2.0 1.9 1.7 1.1 2.2 2.4 2.4 2.3 2.6
Ever unenthusiastic/disinterested for a whole week 2.3 2.8 4.3 1.5 1.6 1.9 1.7 1.5 1.5 -1.8 -1.5 1.6 1.8 1.9 1.5 -2.0 1.6 1.8 1.3 2.0 0.5 2.1 1.7 1.9 1.7 1.8 1.3 1.0
Qualifications: None of the above 0.4 0.8 2.6 -0.9 -0.7 -0.8 -0.7 -0.9 -0.9 1.4 0.9 -1.1 -0.5 -1.3 -0.3 0.8 -0.7 -1.1 -1.2 -1.1 -0.4 -0.9 -0.4 0.9 -0.7 -0.7 -1.6 -0.4
Financial difficulties in last 2 years 5.8 7.9 10.9 3.0 3.3 2.9 3.0 3.0 3.0 -3.0 -3.2 2.9 2.5 3.0 2.4 -3.2 2.9 2.7 2.6 3.0 2.1 2.6 2.1 2.6 2.9 3.0 2.6 2.1
Mouth/teeth dental problems 0.9 1.4 3.5 -1.1 -1.3 -1.4 -1.3 -1.1 -1.1 0.8 1.3 -1.1 -1.7 -1.3 -0.5 1.7 -0.8 -1.3 -1.0 -1.4 0.4 -1.6 -1.4 -1.9 -0.7 -0.9 -0.1 0.4
Heart attack 0.3 0.4 0.9 -0.8 -0.9 -0.6 -0.5 -0.8 -0.7 -0.8 0.9 -0.7 0.1 -0.2 -0.1 0.9 -0.6 -0.2 -0.1 -0.7 -0.5 -0.2 0.7 -0.4 -0.7 -0.7 -0.7 -0.6
Allergy 0.1 0.2 1.7 -0.3 -0.6 -0.2 -0.3 -0.3 -0.4 1.3 0.4 -0.4 0.3 -0.6 -0.3 0.5 -0.5 0.1 -0.4 -0.1 -0.6 0.0 -0.2 0.4 -0.4 -0.5 -0.6 -0.3
Pain all over the body in last month 1.2 1.3 3.0 1.0 1.1 1.3 1.1 0.9 1.0 -1.3 -1.1 1.0 1.3 1.2 1.1 -1.2 1.2 1.3 0.3 1.3 0.8 1.5 1.0 1.7 1.1 1.1 0.5 0.9
Diabetes (self-reported) 0.2 0.3 0.8 0.6 0.2 0.6 0.6 0.6 0.7 -0.6 -0.3 0.6 0.5 0.7 0.3 -0.5 0.2 0.9 0.6 0.6 -0.1 0.7 0.7 0.5 0.3 0.5 0.5 0.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.3 0.0 0.5 -0.1 -0.0 0.0 0.1 -0.5 -0.4 0.2 -0.4 -0.1 -0.4 -0.1 -0.2 -0.3 0.2 -0.2 -0.4 -0.5 -0.3 -0.2 -0.2 -0.1 -0.2 -0.4
Medication: Ramipril 0.7 1.0 1.7 -1.2 -1.1 -1.1 -1.1 -1.2 -1.2 0.4 1.1 -1.1 -1.1 -0.8 -0.8 1.3 -0.9 -1.0 -0.9 -1.0 -0.6 -1.0 -1.2 -0.4 -0.9 -0.9 -0.7 -0.6
Medication: Simvastatin 0.1 0.1 0.8 -0.3 0.1 0.2 -0.0 -0.3 -0.3 0.2 -0.1 -0.2 0.6 -0.0 0.2 0.0 -0.1 -0.2 0.8 -0.2 -0.2 -0.3 0.6 0.9 -0.2 0.1 -0.3 -0.2
Fluid intelligence score 0.1 0.2 0.8 0.8 0.5 0.3 0.5 0.7 0.7 0.8 -0.5 0.5 0.1 0.3 -0.0 -0.0 0.2 0.2 0.4 0.2 0.1 0.2 0.4 -0.9 0.2 -0.2 0.3 -0.1
Illnesses of siblings 1.6 2.3 4.0 -1.5 -1.5 -1.5 -1.5 -1.4 -1.4 1.9 1.3 -1.4 -1.3 -2.0 -1.6 1.7 -1.7 -1.2 -0.4 -1.7 -1.4 -1.6 -0.7 -0.7 -1.9 -1.6 -1.6 -1.8
Neuroticism score 0.6 1.3 4.6 0.8 1.5 1.1 0.8 0.7 0.7 -1.8 -1.2 1.1 0.2 1.5 0.6 -1.2 1.1 1.2 1.1 1.1 0.7 0.7 -0.4 2.1 1.1 1.7 0.9 0.8
Weight 0.6 2.9 9.4 1.6 1.9 2.0 1.6 1.5 1.5 -1.6 -1.8 1.7 1.0 2.1 1.4 -2.5 1.7 1.5 0.4 1.9 1.0 1.6 -0.0 3.1 2.0 2.0 0.6 1.6
Impedance of arm (right) 0.2 1.1 2.4 -0.6 -0.5 -1.1 -0.8 -0.6 -0.6 1.5 0.6 -0.7 -1.3 -1.3 -1.3 1.1 -1.0 -1.1 0.8 -1.1 -1.0 -1.4 -0.3 -1.6 -1.2 -1.1 -0.3 -1.5
Arm fat percentage (right) 0.2 0.9 5.8 0.7 1.0 1.2 0.8 0.6 0.7 -0.2 -0.9 0.8 0.3 0.8 1.0 -1.4 1.2 0.6 0.2 0.9 0.9 0.7 0.0 2.4 1.2 1.2 0.1 1.1
Trunk fat-free mass 0.9 5.2 8.6 2.3 2.2 2.6 2.3 2.3 2.3 -2.4 -2.4 2.5 1.9 2.9 2.0 -2.9 2.2 2.4 1.2 2.6 1.5 2.5 1.0 2.7 2.5 2.4 1.6 2.2
Hip circumference 0.1 0.5 6.4 0.1 0.3 0.6 0.2 0.1 0.1 0.1 -0.4 0.3 -0.2 0.6 -0.1 -1.0 0.1 0.4 -0.6 0.5 -0.8 0.5 -1.0 2.5 0.3 0.3 -1.2 -0.1
Time employed in main current job 0.4 0.5 2.0 -0.8 -0.8 -0.7 -0.8 -0.7 -0.8 1.2 0.7 -0.8 -0.5 -1.2 -0.4 0.9 -0.6 -0.3 -1.4 -0.4 -0.1 -0.3 -0.7 0.2 -0.6 -0.3 -0.4 0.0
Alcohol intake versus 10 years previously 0.3 0.5 1.7 -0.8 -0.2 -0.7 -0.8 -0.8 -0.8 0.7 0.4 -0.7 -0.6 -0.8 -0.0 0.9 -0.4 -0.9 -1.3 -0.9 0.2 -0.9 -1.0 0.4 -0.4 -0.3 -0.9 0.4
Father’s age at death 0.0 0.1 0.1 0.2 0.3 0.1 0.2 0.3 0.2 0.3 -0.4 0.3 0.3 0.3 -0.1 -0.0 0.0 0.3 0.3 0.1 -0.2 0.3 0.2 -0.1 -0.0 -0.2 -0.1 -0.3
Worrier / anxious feelings 0.0 0.1 0.3 -0.5 -0.2 -0.0 -0.3 -0.5 -0.5 -0.1 0.4 -0.3 -0.2 -0.2 0.3 0.4 -0.0 -0.1 0.6 -0.3 0.1 -0.2 0.3 -0.1 -0.1 0.0 0.2 0.1
Frequency of tiredness / lethargy in last 2 weeks 7.2 11.6 15.2 3.9 3.8 3.6 3.5 3.9 3.7 -3.6 -3.6 3.7 2.6 3.7 2.7 -3.8 3.5 3.9 2.1 3.8 2.7 3.6 1.9 3.1 3.7 3.7 2.9 2.8
Falls in the last year 0.6 0.8 2.0 1.1 1.3 1.0 0.7 1.1 0.9 -0.9 -1.2 1.0 0.2 0.9 -0.7 -1.4 0.2 1.4 1.1 1.0 -1.0 1.0 -0.1 0.4 0.4 0.4 0.2 -1.0
Hair/balding pattern: Pattern 3 1.0 1.4 2.1 1.2 1.2 1.4 1.2 1.3 1.2 -0.8 -1.4 1.3 1.0 1.3 0.9 -1.3 1.2 1.3 1.3 1.4 0.7 1.4 1.2 1.0 1.1 1.1 1.3 0.6
Number of live births 0.1 0.1 1.6 -0.0 -0.2 -0.3 -0.1 -0.0 0.1 -1.2 0.3 -0.2 -0.1 0.0 -0.2 0.3 -0.2 -0.3 -0.3 -0.3 0.0 -0.3 0.2 -0.5 -0.3 -0.2 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 9.1 0.9 0.8 1.0 0.8 1.0 0.9 -3.0 -0.8 1.0 0.7 0.7 0.8 -1.0 0.9 1.0 0.5 1.4 1.0 0.8 -0.1 1.8 1.0 1.3 0.9 1.2
Pulse rate 0.8 1.3 2.9 1.6 1.4 1.1 1.4 1.6 1.5 -0.1 -1.2 1.2 0.6 1.6 0.8 -1.7 1.2 0.9 0.5 1.4 0.9 1.1 0.5 0.9 1.2 1.0 0.7 0.7
Happiness 1.6 1.9 3.1 1.6 1.7 1.8 1.6 1.6 1.6 -1.4 -1.6 1.6 1.6 1.5 0.9 -1.5 1.2 1.5 1.6 1.3 0.3 1.4 1.6 1.7 1.2 1.1 0.3 0.3
Noisy workplace 0.6 0.7 3.2 0.7 0.7 0.6 0.6 0.6 0.6 -0.6 -0.6 0.7 0.4 0.9 0.7 -0.8 0.9 0.6 0.3 1.0 1.1 0.4 -0.7 1.8 1.0 1.5 0.9 1.1
Qualifications: A levels/AS levels or equivalent 0.2 0.5 5.3 0.1 -0.4 -0.6 -0.4 0.1 -0.1 -0.4 0.2 -0.1 -1.1 0.1 -0.9 0.4 -0.5 0.1 -1.5 -0.2 -0.4 0.1 -1.0 -2.3 -0.3 -0.8 0.2 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 2.1 0.6 0.9 0.5 0.5 0.6 0.6 -0.9 -0.8 0.6 0.6 1.0 -0.7 -0.6 -0.2 0.9 0.9 0.8 -1.5 0.8 0.3 -0.4 -0.1 -0.2 0.1 -1.3
Mouth/teeth dental problems: Dentures 0.1 0.2 1.6 0.3 0.3 0.3 0.3 0.2 0.3 -0.1 -0.2 0.2 0.5 0.2 -0.5 -0.4 -0.3 0.2 0.3 0.2 -1.0 0.3 0.7 0.6 -0.4 -0.3 -0.8 -1.3
Asthma 0.2 0.4 1.6 -0.6 -0.3 -0.7 -0.6 -0.6 -0.5 -0.5 0.5 -0.6 -0.9 -1.1 -0.2 0.8 -0.3 -1.1 -0.0 -0.8 0.5 -1.3 -0.6 -0.3 -0.5 -0.1 -0.1 0.0
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 3.5 1.4 1.5 1.6 1.4 1.5 1.4 -0.7 -1.5 1.4 1.6 1.3 0.9 -1.7 1.1 1.6 1.5 1.6 0.3 1.5 1.0 1.9 1.2 1.5 1.0 0.4
Medication: Cholesterol lowering 0.0 0.1 0.7 -0.0 0.2 0.2 0.1 -0.0 -0.0 -0.4 -0.2 0.1 -0.1 0.8 -0.1 -0.1 0.0 0.0 0.4 -0.0 -0.1 -0.0 0.1 0.5 -0.0 0.0 -0.2 -0.2
Depression (self-reported) 1.8 2.1 5.7 1.8 2.1 1.3 1.2 1.7 1.5 -2.4 -1.8 1.6 -0.0 1.7 0.1 -1.9 1.5 1.3 0.6 1.6 1.1 1.0 -1.2 0.8 1.5 1.7 1.4 0.6
Medication: Lansoprazole 1.0 1.1 3.0 1.2 1.4 1.3 1.1 1.2 1.1 -0.5 -1.3 1.2 0.7 1.1 0.6 -1.5 1.0 1.2 0.9 1.2 0.3 1.1 0.5 1.7 1.0 1.2 0.4 0.4
Prospective memory result 3.0 3.6 5.7 -2.3 -2.3 -2.1 -2.2 -2.2 -2.3 0.4 2.3 -2.2 -2.2 -2.4 -1.3 1.9 -1.8 -2.2 -2.1 -2.0 -0.8 -2.1 -2.0 -0.6 -1.8 -1.5 -1.7 -0.9
Lung cancer (father) 0.1 0.1 0.4 -0.1 -0.1 0.0 -0.0 -0.2 -0.2 0.6 -0.1 -0.1 0.4 0.4 -0.3 -0.1 -0.1 0.5 -0.4 0.2 -0.5 0.6 -0.4 0.7 0.0 -0.0 -0.3 -0.3
Illnesses of mother 1.1 1.4 2.6 -1.2 -1.3 -1.2 -1.3 -1.2 -1.2 1.1 1.1 -1.2 -1.1 -1.0 -1.2 0.9 -1.3 -1.2 -1.6 -1.1 -1.2 -0.9 -1.0 -0.7 -1.2 -1.6 -1.2 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 9.5 0.9 0.8 0.8 0.7 0.9 0.8 -3.1 -0.8 0.9 0.6 0.6 0.3 -1.0 0.6 1.0 0.5 1.2 0.3 0.9 -0.0 1.1 0.7 0.8 0.6 0.5
Pulse wave Arterial Stiffness index 1.1 1.3 3.0 -1.2 -1.4 -1.3 -1.2 -1.2 -1.3 1.7 1.4 -1.4 -1.3 -1.0 -0.6 1.1 -0.8 -1.6 -0.7 -1.1 0.2 -1.6 -1.6 -0.2 -0.9 -0.7 -0.6 -0.1
Impedance of arm (left) 0.3 1.3 3.2 -1.0 -0.7 -1.3 -1.0 -0.9 -0.9 1.3 0.8 -1.0 -1.3 -1.5 -1.2 1.5 -1.1 -1.4 0.9 -1.4 -0.8 -1.8 -0.4 -1.7 -1.3 -1.0 -0.2 -1.4
Arm fat mass (right) 0.7 2.7 9.5 1.5 1.8 2.0 1.6 1.4 1.5 -1.1 -1.6 1.6 1.0 1.8 1.6 -2.3 1.9 1.3 0.7 1.8 1.3 1.5 0.5 3.1 2.0 2.0 0.7 1.7
Trunk predicted mass 0.9 4.9 8.3 2.2 2.2 2.5 2.2 2.2 2.2 -2.3 -2.3 2.3 1.9 2.9 2.0 -2.8 2.2 2.3 1.1 2.6 1.4 2.4 1.0 2.7 2.5 2.3 1.5 2.1
Standing height 0.6 5.9 9.5 2.8 2.8 2.6 2.6 2.8 2.8 -2.6 -2.9 2.9 2.0 3.1 1.5 -3.0 2.0 2.7 2.6 2.8 0.7 2.3 1.4 2.3 2.3 2.4 1.9 1.2
Length of working week for main job 0.1 0.1 0.7 0.1 -0.4 -0.3 -0.1 0.1 0.2 -0.3 0.4 0.0 -0.5 -0.4 0.1 0.4 -0.0 -0.1 -0.7 -0.1 0.5 -0.1 -0.0 -0.8 0.0 -0.2 0.2 0.6
Exposure to tobacco smoke at home 0.2 0.2 0.8 -0.1 0.1 -0.0 -0.1 -0.1 -0.1 0.1 -0.0 -0.1 -0.9 0.4 0.5 -0.5 0.3 -0.3 -0.4 0.0 0.6 -0.3 -0.9 0.5 0.4 0.5 0.2 0.9
Breastfed as a baby 0.1 0.1 0.7 -0.3 -0.1 -0.0 -0.1 -0.2 -0.3 0.3 -0.0 -0.1 0.3 0.5 -0.3 -0.1 -0.3 0.2 0.3 -0.1 -0.8 0.3 0.5 0.1 -0.3 -0.4 -0.6 -0.8
Tense / ‘highly strung’ 0.8 1.4 2.8 1.1 1.6 1.2 1.0 1.1 1.0 -1.0 -1.5 1.3 0.3 1.5 0.7 -1.6 1.2 1.2 0.9 1.2 0.9 1.0 -0.3 1.7 1.3 1.5 0.9 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 2.8 4.2 8.9 2.3 2.7 2.3 2.1 2.2 2.1 -1.9 -2.5 2.4 1.2 3.0 0.8 -2.9 1.9 2.5 1.6 2.5 0.5 2.4 0.6 2.1 2.0 2.0 1.3 0.4
Hair/balding pattern: Pattern 4 0.8 2.0 3.3 -1.3 -1.7 -1.6 -1.5 -1.3 -1.3 1.8 1.5 -1.4 -0.8 -1.4 -1.3 1.6 -1.5 -1.4 -1.7 -1.4 -0.9 -1.5 -1.4 -0.5 -1.5 -1.5 -1.7 -0.8
Birth weight of first child 0.1 0.3 1.7 -0.2 -0.6 -0.1 -0.0 -0.2 -0.1 0.3 0.4 -0.2 0.1 -0.6 0.8 0.3 0.3 0.0 0.1 0.1 1.1 -0.1 0.1 -0.1 0.3 0.5 1.1 1.3
Peak expiratory flow (PEF) 0.2 0.4 5.3 0.4 0.0 0.5 0.2 0.4 0.3 -2.3 -0.1 0.4 0.4 0.4 0.4 -0.5 0.5 0.3 0.2 0.8 0.7 0.4 -0.1 0.3 0.5 0.6 0.9 0.8
Pulse wave reflection index 0.4 0.5 2.0 -0.8 -0.7 -0.5 -0.7 -0.8 -0.8 0.7 0.7 -0.7 -0.5 -0.7 0.6 0.7 0.2 -0.8 -0.7 -0.4 1.4 -0.8 -1.0 0.8 0.1 0.3 0.1 1.3
Ever highly irritable/argumentative for 2 days 2.9 3.4 9.4 2.3 1.9 2.0 2.1 2.3 2.3 -3.1 -2.0 2.3 1.4 2.5 0.4 -2.5 1.2 1.9 2.2 2.1 -0.6 1.9 1.1 0.8 1.4 1.4 1.1 -0.2
Loud music exposure frequency 0.1 0.2 0.8 0.5 0.1 -0.1 0.4 0.5 0.6 0.0 -0.0 0.3 -0.0 -0.1 0.5 0.1 0.3 -0.0 0.2 0.2 0.9 -0.2 -0.0 -0.3 0.3 0.4 0.6 0.8
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 2.3 0.4 -0.0 0.4 0.4 0.3 0.3 -0.1 -0.1 0.3 0.2 0.3 0.6 -0.2 0.4 0.1 0.6 0.4 0.5 0.3 0.6 -1.5 0.4 0.0 1.1 0.7
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 3.1 0.8 1.2 1.1 0.9 0.8 0.8 0.1 -1.2 0.9 1.3 0.6 0.8 -1.1 0.8 0.9 1.6 0.9 0.2 0.8 0.8 1.8 0.8 1.1 0.7 0.4
Blood clot in the leg (DVT) 0.2 0.3 1.7 0.0 0.3 0.3 0.3 0.0 0.1 1.0 -0.3 0.1 0.9 0.2 0.1 -0.4 -0.0 0.3 1.3 0.1 -0.5 0.4 1.2 0.2 -0.2 -0.4 -0.2 -0.7
Medication: Paracetamol 0.4 0.7 1.8 1.0 0.9 0.8 1.1 0.9 0.9 -0.4 -0.7 0.7 0.7 0.8 1.1 -0.9 1.1 0.2 0.2 0.7 0.9 0.6 0.7 1.4 1.1 0.9 0.4 0.9
Headache pain in last month 0.0 0.1 0.3 0.1 0.1 -0.1 -0.0 0.1 0.0 -0.4 0.1 -0.0 -0.1 0.1 -0.4 0.1 -0.2 -0.5 0.0 -0.1 -0.4 -0.5 -0.5 -0.2 -0.2 -0.3 -0.3 -0.5
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.8 1.3 0.9 1.1 1.3 1.3 1.3 0.6 -1.1 1.2 1.7 0.4 1.2 -1.3 1.1 1.0 1.5 1.1 0.7 1.1 1.7 0.7 1.1 1.0 1.0 0.7
Glaucoma (self-reported) 1.2 1.4 3.9 1.4 1.2 1.1 1.3 1.4 1.3 -1.2 -1.1 1.3 1.2 2.0 0.8 -1.3 1.0 1.4 0.3 1.4 0.2 1.7 0.9 0.8 1.2 0.8 0.7 0.6
Gout (self-reported) 4.1 5.7 7.6 2.6 2.4 2.4 2.5 2.6 2.6 -2.2 -2.4 2.4 1.9 2.5 2.4 -2.5 2.7 2.4 1.7 2.4 2.6 2.3 1.7 1.5 2.7 2.8 2.6 2.4
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 4.2 0.8 1.1 1.2 0.9 0.8 0.8 -1.9 -1.1 1.0 1.2 1.2 0.9 -1.1 0.8 1.3 1.1 1.4 0.1 1.3 0.9 2.0 1.0 1.2 0.5 0.5
Medication: Amlodipine 0.3 0.4 2.1 0.6 0.4 0.6 0.5 0.6 0.6 -1.4 -0.5 0.7 0.1 0.6 0.6 -0.5 0.7 0.3 -0.4 0.8 0.9 0.6 0.0 -0.1 0.7 0.5 0.7 0.9
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.8 -0.8 -0.1 -0.7 -1.1 -0.8 -0.9 -1.2 0.4 -0.7 -1.7 -0.4 -1.7 0.5 -1.1 -0.5 -0.1 -0.7 -1.4 -0.9 -1.4 -1.3 -1.1 -0.7 -0.4 -1.3
Birth weight 0.3 0.6 2.3 0.7 0.6 0.6 0.7 0.7 0.7 1.5 -0.7 0.5 0.6 0.6 1.1 -0.7 0.8 0.7 -0.1 0.5 0.9 0.8 0.8 1.1 0.9 0.8 0.3 1.2
Chronic bronchitis/emphysema (mother) 0.2 0.2 1.1 -0.1 -0.0 -0.1 -0.2 -0.1 -0.2 -0.7 0.1 -0.3 -0.3 -0.2 -0.7 0.1 -0.6 0.3 0.1 -0.2 -1.1 0.0 0.1 -0.0 -0.5 -0.3 -0.8 -0.9
High blood pressure (siblings) 0.4 0.6 1.6 0.7 0.4 0.6 0.8 0.7 0.7 -1.2 -0.3 0.6 1.0 1.2 1.0 -0.5 0.7 0.5 0.0 0.8 0.6 0.9 1.1 -0.5 0.8 0.4 0.7 0.9
Forced vital capacity (FVC), Best measure 0.4 1.4 6.0 1.2 1.1 1.1 1.0 1.2 1.1 -2.5 -1.2 1.2 0.9 0.9 0.7 -1.2 1.0 1.3 1.1 1.5 0.8 1.0 0.0 1.7 1.1 1.3 1.1 0.9
Body fat percentage 0.2 0.7 7.1 0.6 1.1 1.0 0.7 0.5 0.6 0.0 -0.9 0.6 0.3 0.6 0.3 -1.3 0.7 0.5 0.3 0.8 -0.1 0.5 -0.3 2.7 0.8 0.9 -0.6 0.1
Leg fat percentage (right) 0.2 0.7 4.9 -0.0 0.4 0.2 0.0 -0.1 -0.1 0.2 -0.2 -0.0 -0.2 0.1 -0.9 -0.8 -0.5 0.1 -0.4 0.2 -1.8 0.2 -0.9 2.2 -0.3 -0.2 -1.9 -1.4
Arm fat-free mass (right) 0.7 3.4 7.1 1.8 1.7 2.1 1.8 1.8 1.8 -2.1 -1.8 1.9 1.8 2.3 1.7 -2.3 1.8 1.9 0.7 2.2 1.1 2.0 0.7 2.7 2.0 2.0 1.0 1.7
Exposure to tobacco smoke outside home 0.9 1.2 2.5 1.3 1.4 0.9 1.1 1.2 1.3 -1.0 -1.2 1.1 0.3 1.1 0.8 -1.3 1.2 0.5 0.4 1.1 1.3 0.4 -0.5 1.6 1.2 1.5 0.9 1.1
Comparative body size at age 10 0.1 0.2 1.5 0.7 0.4 0.4 0.4 0.6 0.6 1.2 -0.5 0.5 0.0 0.3 -0.2 -0.2 0.0 0.4 0.2 0.2 -0.6 0.2 -0.3 0.1 0.3 -0.1 -0.2 -0.3
Number of full brothers 0.4 0.5 1.6 0.7 0.5 0.5 0.4 0.7 0.5 -0.9 -0.6 0.7 0.0 0.8 -0.9 -1.2 -0.1 1.0 0.1 0.5 -1.1 0.8 -0.3 0.2 -0.0 -0.0 -0.5 -1.2
Worry too long after embarrassment 0.0 0.1 0.9 0.1 0.0 0.4 0.1 0.0 0.1 -0.2 -0.0 0.3 -0.1 -0.1 0.1 0.1 0.2 0.4 0.5 0.1 0.0 0.2 0.3 1.0 0.1 0.4 -0.1 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 5.2 6.7 10.0 2.8 2.8 2.8 2.6 2.7 2.7 -2.7 -2.5 2.8 1.6 2.9 2.2 -3.2 2.8 2.5 1.6 3.0 2.3 2.5 0.8 2.5 3.0 3.1 2.6 2.5
Wheeze or whistling in the chest in last year 0.1 0.2 1.3 0.1 0.4 0.1 0.2 0.0 0.1 -0.6 -0.2 0.1 -0.1 0.2 -0.5 -0.4 -0.3 0.1 0.3 -0.0 -1.1 0.2 0.6 0.0 -0.2 -0.3 -0.5 -1.1
Number of children fathered 0.8 0.9 1.6 0.8 1.0 1.1 1.0 0.8 0.9 -0.8 -1.0 1.0 1.0 1.0 1.0 -1.2 1.0 0.7 1.1 0.9 0.4 1.1 1.2 1.0 1.0 0.7 0.6 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.0 0.4 0.1 0.4 0.5 0.5 0.5 0.2 -0.2 0.5 0.2 0.7 0.1 -0.1 -0.1 0.5 0.7 0.1 -0.6 0.3 1.0 0.5 -0.1 -0.0 -0.4 -0.6
Age at first live birth 0.6 1.1 5.7 0.4 0.2 0.4 0.4 0.4 0.4 1.5 -0.3 0.5 0.1 -0.0 1.6 -0.1 1.2 -0.1 0.6 0.6 2.3 0.1 0.1 -0.5 1.2 1.1 2.2 2.4
Pulse wave peak to peak time 1.3 1.5 3.1 1.3 1.5 1.4 1.3 1.3 1.3 -1.8 -1.5 1.5 1.3 1.2 0.7 -1.3 0.9 1.6 0.7 1.2 -0.1 1.7 1.6 0.3 1.0 0.8 0.7 0.3
Health satisfaction 2.6 3.3 4.9 2.0 2.2 2.1 1.8 2.0 1.9 -1.5 -2.1 2.0 1.2 1.9 1.5 -2.1 2.0 1.6 1.8 1.9 1.6 1.3 0.9 1.8 2.0 2.2 1.7 1.6
Shortness of breath walking on level ground 0.1 0.1 1.2 0.2 -0.1 0.2 0.2 0.2 0.2 -0.1 0.1 0.0 0.3 0.1 -0.1 -0.0 -0.2 0.1 0.1 -0.0 -0.6 0.0 0.2 1.1 -0.1 -0.0 -0.9 -0.4
Qualifications: College or University degree 0.1 0.3 3.1 -0.3 -0.5 -0.5 -0.5 -0.2 -0.3 -0.1 0.3 -0.3 -0.6 -0.3 -0.1 0.7 -0.0 0.3 0.1 -0.1 0.7 0.1 -0.1 -1.8 -0.1 -0.2 1.0 0.5
Eye problems/disorders: None of the above 1.7 2.0 4.2 -1.4 -1.5 -1.6 -1.6 -1.4 -1.4 1.2 1.5 -1.5 -1.6 -2.0 -1.0 1.7 -1.1 -1.5 -1.9 -1.6 -0.1 -1.8 -2.0 -0.9 -1.1 -0.9 -0.9 -0.1
Mouth/teeth dental problems: Loose teeth 4.1 4.9 8.2 2.1 2.3 2.3 2.3 2.1 2.2 -1.6 -2.5 2.0 2.9 2.6 2.0 -2.4 2.0 2.8 2.2 2.4 1.0 2.8 2.6 1.6 2.1 2.1 2.0 1.3
Emphysema/chronic bronchitis 3.3 3.7 8.9 1.4 1.7 1.7 1.8 1.4 1.5 -0.7 -1.6 1.5 1.6 1.6 3.0 -1.4 2.4 1.2 1.9 1.6 3.0 1.2 1.9 1.9 2.3 2.5 2.4 3.0
Medication for pain relief, constipation, heartburn 2.6 4.4 7.7 -2.2 -2.4 -2.4 -2.4 -2.2 -2.2 1.8 2.3 -2.1 -2.2 -2.5 -1.6 2.6 -1.9 -2.1 -2.0 -2.3 -0.6 -2.3 -2.1 -2.8 -1.9 -2.0 -1.2 -0.7
Neck or shoulder pain in last month 0.1 0.1 0.4 0.2 0.6 0.5 0.3 0.2 0.2 -0.3 -0.4 0.1 0.3 0.4 0.5 -0.4 0.3 0.3 -0.4 0.6 0.2 0.7 0.4 0.3 0.4 0.1 0.2 0.4
Medication: Blood pressure 1.5 2.7 7.5 -1.7 -1.5 -1.7 -1.9 -1.6 -1.7 -0.7 1.7 -1.7 -2.2 -1.4 -1.6 1.8 -1.6 -1.3 -2.7 -1.5 -0.9 -1.3 -2.0 -1.8 -1.5 -1.5 -1.3 -0.7
Angina (self-reported) 0.1 0.1 0.4 -0.2 0.0 0.2 -0.0 -0.2 -0.2 0.4 -0.1 -0.1 0.6 -0.0 -0.1 -0.0 -0.3 -0.1 0.6 -0.1 -0.6 -0.1 0.6 0.0 -0.3 -0.3 -0.3 -0.5
Migraine (self-reported) 0.7 0.9 2.1 1.1 0.5 0.9 1.0 1.1 1.1 -1.1 -0.5 1.1 0.6 1.5 0.6 -1.2 1.0 0.8 0.8 1.1 0.7 1.0 0.8 -0.2 0.9 0.9 1.2 0.5
Medication: Ibuprofen 1.6 1.9 3.6 1.6 1.4 1.6 1.6 1.6 1.5 -0.6 -1.4 1.5 1.7 1.6 0.7 -1.9 1.1 1.6 1.7 1.6 0.0 1.6 1.4 1.3 1.1 1.2 1.1 0.0
Medication: Allopurinol 0.9 1.2 5.1 1.0 0.8 0.7 0.9 0.9 1.0 -0.2 -0.7 0.7 0.5 1.1 1.5 -1.0 1.6 0.5 -0.1 0.8 2.2 0.7 0.3 0.3 1.5 1.2 1.3 2.0
Medication: Omeprazole 0.3 0.4 1.3 0.4 0.6 0.7 0.7 0.4 0.5 0.1 -0.3 0.3 0.4 0.5 0.9 -0.6 0.8 0.2 1.1 0.6 0.6 0.3 0.7 0.4 0.7 0.7 0.9 0.5
Medication: Seretide 50 evohaler 0.3 0.3 1.3 -0.0 0.4 -0.2 -0.2 -0.1 -0.0 -0.5 -0.1 0.1 -1.0 -0.3 0.1 0.3 0.3 -0.6 0.5 -0.2 1.0 -1.1 -1.1 0.3 0.2 0.8 0.6 0.7
Mean time to correctly identify matches 0.2 0.3 0.8 0.6 0.8 0.5 0.6 0.6 0.6 0.5 -0.6 0.4 0.8 0.3 0.5 -0.5 0.5 0.8 -0.1 0.5 0.4 0.9 0.8 0.7 0.5 0.3 -0.1 0.3
Heart disease (mother) 1.2 1.4 4.3 1.1 1.0 1.4 1.4 1.0 1.1 -1.5 -1.0 1.2 1.5 1.6 0.9 -1.4 1.0 1.1 2.1 1.2 0.0 1.2 1.5 0.7 1.0 1.1 1.0 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.6 0.5 0.6 0.7 0.6 0.4 0.5 -1.0 -0.5 0.5 0.5 1.1 0.8 -0.9 0.7 0.4 1.0 0.7 0.5 0.6 0.6 -0.6 0.9 0.8 1.6 0.8
Whole body fat mass 0.7 2.8 11.8 1.6 1.9 2.0 1.7 1.5 1.5 -1.0 -1.8 1.6 1.1 1.8 1.3 -2.4 1.7 1.5 0.7 1.9 0.8 1.6 0.3 3.4 1.9 1.9 0.3 1.2
Leg fat mass (right) 0.3 1.2 8.0 1.0 1.2 1.3 1.0 0.9 0.9 -0.7 -1.1 1.0 0.6 1.2 0.4 -1.8 0.7 1.1 -0.1 1.2 -0.3 1.2 -0.2 2.8 1.0 0.9 -0.6 0.1
Arm predicted mass (right) 0.9 4.5 8.0 2.1 2.1 2.5 2.1 2.1 2.1 -2.2 -2.1 2.2 2.0 2.5 2.0 -2.6 2.1 2.1 1.0 2.5 1.4 2.2 1.0 2.8 2.3 2.3 1.3 2.0
Pulse rate, automated reading 2.1 6.7 10.4 3.0 2.9 2.8 3.0 2.9 2.9 0.0 -2.7 2.6 2.4 2.9 2.6 -3.2 2.9 2.1 2.1 2.8 2.4 2.3 1.8 2.5 2.9 2.8 2.3 2.3
Alcohol intake frequency. 0.7 1.7 3.8 1.1 1.1 1.4 1.2 1.1 1.1 -1.3 -1.1 1.1 1.1 1.7 1.8 -1.3 1.6 0.8 0.5 1.2 1.7 1.0 0.5 1.7 1.7 1.6 1.1 2.0
Comparative height size at age 10 0.4 2.2 4.4 1.2 1.6 1.6 1.4 1.2 1.2 -1.1 -1.8 1.4 2.0 1.9 1.2 -1.6 1.2 1.7 2.1 1.8 0.5 1.6 1.4 1.9 1.3 1.5 1.3 0.9
Number of full sisters 1.3 1.5 3.9 1.4 1.8 1.6 1.2 1.4 1.3 -1.6 -1.6 1.4 0.9 1.4 0.0 -1.7 0.9 1.6 0.0 1.2 -0.1 1.5 0.4 2.0 0.9 0.9 -0.3 -0.2
Suffer from ‘nerves’ 0.1 0.1 0.9 -0.3 0.1 -0.2 -0.3 -0.4 -0.4 -0.5 0.2 -0.2 -0.7 -0.1 -0.2 -0.0 -0.1 -0.4 0.1 -0.2 -0.0 -0.6 -1.0 0.2 0.0 0.2 0.2 0.1
Overall health rating 0.0 0.1 0.6 0.0 0.4 0.0 0.0 0.0 0.0 -0.4 -0.1 -0.0 -0.2 0.3 0.2 -0.2 0.1 -0.2 -0.6 -0.1 0.3 -0.2 -0.6 0.8 0.2 0.2 -0.3 0.5
Chest pain or discomfort 0.9 1.2 3.7 1.5 1.8 1.1 1.0 1.3 1.2 -1.9 -1.4 1.4 0.1 1.5 -0.2 -1.6 0.8 1.0 0.4 1.4 -0.2 1.0 -0.7 0.6 1.0 0.9 0.6 -0.0
Had major operations 0.9 1.1 5.6 -0.9 -0.4 -1.0 -1.2 -0.9 -1.0 0.4 0.5 -0.7 -2.0 -0.7 -1.4 0.5 -0.9 -1.0 -0.9 -1.0 -0.7 -1.5 -2.4 -0.4 -0.8 -0.6 -0.7 -0.7
Age at last live birth 0.5 0.8 5.6 0.2 -0.1 0.1 0.2 0.2 0.2 1.1 -0.1 0.1 0.1 0.0 1.4 0.1 0.9 0.1 -0.0 0.5 2.0 0.1 -0.1 -0.2 1.0 1.0 1.7 2.4
Family relationship satisfaction 0.6 0.7 3.6 1.1 1.2 0.8 0.8 1.1 1.1 -1.9 -1.1 1.0 0.7 0.8 -0.1 -0.7 0.5 1.0 0.5 0.8 0.1 0.7 0.4 0.5 0.4 0.6 -0.0 -0.2
Leg pain on walking 0.7 0.9 3.3 -1.1 -1.0 -1.0 -1.0 -1.2 -1.1 1.8 1.2 -1.0 -0.7 -0.8 -0.4 0.8 -0.6 -1.5 -0.4 -1.0 -0.1 -1.3 -1.2 -0.5 -0.6 -0.9 -0.5 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.0 5.8 0.0 -0.0 0.3 0.4 -0.1 0.0 0.6 0.1 -0.0 0.7 0.3 2.0 -0.1 1.3 -0.2 0.5 0.4 2.4 -0.2 -0.0 1.4 1.2 1.4 1.4 2.4
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.9 0.2 -0.3 0.1 0.3 0.1 0.2 0.1 0.0 0.2 0.7 0.7 0.7 -0.0 0.5 0.3 0.7 0.5 0.6 0.5 0.5 -0.0 0.5 0.4 1.0 0.6
Illness, injury, bereavement, stress in last 2 years 2.3 2.8 4.2 -1.7 -1.9 -1.7 -1.6 -1.7 -1.6 1.6 1.8 -1.7 -1.6 -1.8 -1.4 1.8 -1.7 -2.0 -1.4 -2.0 -1.3 -1.9 -1.3 -1.0 -1.7 -1.7 -1.8 -1.3
Medication: Aspirin 0.4 0.6 1.6 0.7 0.7 0.7 0.8 0.7 0.8 -1.1 -0.7 0.8 0.8 1.1 0.1 -0.6 0.3 0.9 1.3 0.5 -0.4 0.7 1.0 0.9 0.3 0.3 -0.1 -0.6
Supplements: Vitamin C 0.9 1.0 2.4 1.0 0.9 1.1 1.0 1.0 1.0 -0.0 -1.0 1.1 1.3 0.5 0.8 -1.1 1.0 1.2 1.6 1.1 0.6 1.0 0.7 1.5 0.9 1.1 1.0 0.5
Knee pain experienced in last month 0.0 0.0 0.3 -0.0 0.1 0.2 0.1 -0.0 0.0 0.3 -0.1 0.0 0.2 0.1 0.3 0.1 0.3 -0.2 0.2 -0.1 0.4 -0.2 -0.0 0.6 0.2 0.2 -0.0 0.3
Hypertension (Self-reported) 0.8 2.1 5.0 -1.2 -0.9 -1.2 -1.4 -1.2 -1.3 0.0 1.1 -1.1 -1.8 -0.9 -2.2 0.8 -1.7 -1.0 -1.7 -1.2 -2.2 -1.1 -2.0 -1.1 -1.6 -1.6 -1.9 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.6 4.8 -1.6 -1.5 -1.6 -1.8 -1.7 -1.7 0.2 1.7 -1.6 -1.9 -1.5 -2.0 1.2 -1.7 -1.6 -1.9 -1.6 -1.5 -1.5 -2.2 -1.0 -1.6 -1.6 -1.7 -1.5
Illnesses of father: Heart disease 0.4 0.6 2.3 0.5 0.8 0.8 0.6 0.5 0.5 -1.5 -0.7 0.6 1.0 0.4 0.1 -0.4 0.0 1.0 1.3 0.6 -0.8 0.7 1.5 0.3 0.0 0.4 0.2 -0.7
Illnesses of siblings: Diabetes 2.3 2.8 4.2 1.6 1.3 1.8 1.9 1.5 1.6 -0.3 -1.5 1.8 1.5 2.1 1.9 -2.0 1.9 1.4 1.7 1.9 1.4 1.7 1.4 1.7 2.0 1.9 1.8 1.5
Smoking status: Previous 1.1 1.6 3.2 1.3 1.0 1.3 1.4 1.3 1.3 -0.1 -1.0 1.1 1.2 1.4 1.5 -1.4 1.3 1.4 0.5 1.5 1.0 1.7 1.3 1.8 1.4 1.3 1.0 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 1.5 0.4 0.0 0.2 0.2 0.4 0.4 -1.2 -0.2 0.5 0.2 0.1 0.4 -0.1 0.3 0.0 0.1 0.4 0.6 -0.1 -0.4 0.5 0.3 0.4 0.6 0.7
Whole body fat-free mass 0.9 5.0 7.8 2.2 2.1 2.5 2.2 2.2 2.2 -2.1 -2.2 2.3 1.8 2.7 2.2 -2.8 2.4 2.2 0.8 2.5 1.9 2.3 0.8 2.8 2.6 2.5 1.6 2.5
Leg fat-free mass (right) 0.8 4.5 11.5 1.9 1.8 2.2 1.8 1.9 1.9 -1.9 -1.9 1.9 1.1 2.2 2.5 -2.4 2.5 1.6 0.3 2.2 2.8 1.7 0.2 2.5 2.7 2.6 2.0 3.4
Arm fat percentage (left) 0.2 0.7 4.9 0.4 0.8 1.0 0.6 0.3 0.4 -0.2 -0.7 0.5 0.2 0.6 0.9 -1.2 1.0 0.3 0.1 0.7 0.9 0.4 -0.2 2.2 1.0 1.1 0.1 1.1
Average weekly red wine intake 0.1 0.2 1.5 0.2 0.2 0.2 0.2 0.2 0.2 0.2 -0.4 0.1 0.5 -0.2 0.4 0.3 0.3 0.4 1.2 0.2 0.4 0.2 0.7 -0.6 0.3 0.4 1.0 0.3
Handedness (chirality/laterality): Left-handed 2.4 2.9 4.7 1.7 1.9 1.9 1.8 1.7 1.7 -1.3 -1.9 1.9 2.0 1.7 1.6 -1.6 1.6 1.8 1.8 1.8 1.0 1.6 1.5 2.2 1.6 1.8 1.4 1.3
Mood swings 1.7 3.1 7.2 1.8 2.4 1.8 1.6 1.8 1.6 -2.7 -2.2 1.9 1.2 2.3 0.5 -2.1 1.4 2.4 1.0 2.0 0.0 2.1 0.5 2.5 1.6 2.0 0.7 0.4
Loneliness, isolation 1.2 1.6 3.0 1.3 1.5 1.2 1.2 1.3 1.2 -1.6 -1.4 1.4 0.6 1.7 1.0 -1.5 1.4 1.4 0.1 1.4 1.1 1.4 0.5 1.2 1.4 1.4 0.9 1.1
Long-standing illness, disability or infirmity 1.7 2.7 6.5 1.4 2.1 2.1 1.6 1.4 1.4 -1.8 -1.9 1.6 1.3 2.0 1.4 -1.8 1.6 1.5 1.8 1.6 0.8 1.3 1.1 2.5 1.6 1.9 1.0 1.1
Ever had bowel cancer screening 1.2 1.5 5.8 -0.8 -1.1 -0.7 -0.9 -0.8 -0.9 0.4 1.0 -0.8 -1.0 -0.6 -1.8 0.7 -1.5 -0.6 -1.1 -0.9 -2.3 -0.5 -0.2 -0.7 -1.6 -1.5 -1.9 -2.4
Diabetes diagnosed by doctor 0.1 0.1 0.3 0.2 -0.1 0.3 0.2 0.2 0.2 -0.2 0.1 0.2 0.2 0.5 0.4 -0.3 0.1 0.3 0.1 0.3 0.1 0.3 0.5 0.3 0.3 0.4 0.4 0.6
Ever had stillbirth, spontaneous miscarriage or termination 2.4 2.6 7.1 1.6 1.6 1.8 1.8 1.6 1.6 0.3 -1.7 1.5 2.5 1.3 1.3 -1.5 1.2 1.9 2.2 1.6 0.0 2.0 2.7 2.1 1.2 1.0 0.7 0.2
Friendships satisfaction 0.3 0.3 1.9 0.6 1.0 0.4 0.4 0.6 0.6 -1.4 -0.6 0.5 -0.2 0.5 0.1 -0.4 0.4 0.4 0.2 0.3 0.4 0.1 -0.1 -1.1 0.4 0.3 0.6 0.3
Qualifications: nursing, teaching 0.1 0.2 1.3 -0.0 -0.1 -0.0 -0.2 0.0 -0.1 -0.1 -0.0 0.2 -0.2 0.1 -1.0 -0.0 -0.5 0.3 0.0 0.1 -1.1 0.2 -0.4 -1.1 -0.4 -0.5 -0.1 -1.0
Commuting to job workplace: Walk 0.4 0.4 1.1 -0.5 -0.8 -0.7 -0.5 -0.5 -0.5 0.6 0.8 -0.7 -0.6 -1.0 -0.0 0.7 -0.4 -0.6 -1.0 -0.9 0.2 -0.7 -0.6 -0.8 -0.3 -0.5 -0.5 0.5
Eye problems/disorders: Cataract 0.2 0.2 1.3 -0.2 -0.1 -0.0 0.1 -0.2 -0.0 1.1 0.2 -0.2 0.5 -0.0 0.6 0.2 0.1 -0.4 0.6 -0.1 0.3 -0.0 1.2 -0.6 -0.1 -0.3 0.2 0.1
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.6 -1.3 -1.4 -0.9 -1.1 -1.1 -1.2 0.9 1.2 -1.2 -0.9 -0.8 -1.2 0.8 -1.4 -1.2 -1.3 -1.1 -1.6 -0.9 -0.4 -0.8 -1.4 -1.4 -1.5 -1.3
Medication for cholesterol 0.1 0.1 1.1 0.1 0.1 -0.2 0.0 0.2 0.1 -0.9 -0.1 -0.0 0.1 -0.0 -0.2 0.4 -0.0 0.3 0.2 0.0 0.2 0.1 0.6 -1.0 -0.2 -0.0 0.4 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.9 0.6 0.9 0.5 0.5 0.6 0.6 -1.0 -0.6 0.6 0.1 0.4 0.2 -0.7 0.4 0.2 -0.1 0.4 0.2 0.3 0.0 -0.4 0.5 0.3 0.3 0.3
Back pain experienced in last month 0.4 0.6 1.9 0.3 1.0 0.9 0.4 0.2 0.1 -1.4 -0.6 0.4 0.1 1.1 0.8 -1.0 0.9 0.3 0.2 0.8 0.6 0.5 -0.5 1.0 1.1 1.0 0.7 1.0
Mineral and other dietary supplements 0.2 0.2 0.6 0.7 0.6 0.5 0.7 0.7 0.8 -0.0 -0.5 0.7 0.0 0.6 0.4 -0.5 0.5 0.3 0.7 0.2 0.3 0.3 0.4 0.5 0.5 0.3 0.0 0.1
Breast cancer (self-reported) 0.1 0.1 0.7 0.2 0.2 -0.2 -0.1 0.3 0.2 -0.6 -0.0 0.1 -0.5 -0.1 -0.6 0.2 -0.1 0.1 -0.8 0.2 0.2 -0.1 -0.7 -0.2 -0.2 0.1 0.1 -0.1
Asthma (self-reported) 0.3 0.6 2.2 -0.8 -0.5 -0.8 -0.8 -0.8 -0.7 -0.1 0.7 -0.8 -1.1 -1.3 -0.4 0.9 -0.5 -1.3 -0.1 -1.0 0.3 -1.5 -0.7 -0.4 -0.7 -0.3 -0.3 -0.2
Osteoporosis (self-reported) 0.4 0.5 2.5 -0.1 -0.6 -0.6 -0.3 -0.1 -0.1 0.4 0.7 -0.4 -0.4 -0.3 -1.1 0.6 -0.9 -0.4 0.1 -0.7 -1.1 -0.4 0.2 -1.2 -1.0 -1.1 -0.7 -1.6
Osteoarthritis (self-reported) 0.7 1.0 2.7 0.9 0.9 1.3 1.1 0.8 0.9 0.1 -0.9 0.8 1.4 1.3 1.1 -0.8 1.0 0.9 1.7 0.7 0.2 1.0 1.6 0.5 1.0 0.7 0.7 0.4
Medication: Aspirin 0.2 0.2 1.1 0.2 0.2 0.1 0.3 0.2 0.3 -0.7 -0.1 0.2 0.2 0.5 -0.3 -0.0 -0.2 0.2 1.0 -0.1 -0.8 0.0 0.7 0.3 -0.3 -0.3 -0.5 -1.0
Medication: Gliclazide 0.6 0.7 3.0 -0.9 -0.7 -0.7 -1.0 -0.9 -1.0 -0.7 0.7 -0.8 -1.4 -0.5 -0.9 0.5 -0.8 -0.6 -1.2 -0.6 -0.7 -0.8 -1.7 0.1 -0.6 -0.2 -0.7 -0.3
Illnesses of father: None of the above (group 1) 0.1 0.1 0.4 0.3 0.2 -0.1 0.2 0.3 0.3 -0.0 -0.3 0.3 -0.6 0.3 -0.1 -0.3 0.3 0.1 -0.6 0.1 0.4 0.3 -0.6 -0.6 0.3 -0.1 0.1 0.1
Smoking status: Current 1.1 1.7 3.5 1.5 1.9 1.3 1.5 1.6 1.5 -1.3 -1.7 1.6 1.5 1.6 0.5 -1.5 1.0 1.6 1.1 1.3 0.2 1.6 1.5 0.7 0.9 0.9 0.6 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.7 3.7 0.8 0.6 0.9 0.7 0.8 0.7 -1.9 -0.7 0.7 0.7 0.7 -0.2 -1.1 0.1 1.3 0.1 1.1 -1.0 1.6 0.9 0.4 0.3 0.0 -0.3 -0.7
Whole body water mass 0.9 5.2 8.0 2.3 2.2 2.6 2.2 2.2 2.2 -2.2 -2.3 2.4 1.8 2.8 2.3 -2.8 2.4 2.2 0.9 2.6 2.0 2.3 0.9 2.7 2.7 2.5 1.8 2.6
Leg predicted mass (right) 0.9 4.7 12.1 1.9 1.8 2.3 1.9 1.9 1.9 -1.8 -1.9 2.0 1.2 2.3 2.6 -2.5 2.6 1.6 0.3 2.2 2.9 1.8 0.3 2.5 2.8 2.7 2.0 3.5
Arm fat mass (left) 0.6 2.5 9.2 1.3 1.6 1.9 1.5 1.3 1.3 -1.2 -1.5 1.4 1.0 1.7 1.6 -2.1 1.8 1.3 0.5 1.7 1.4 1.4 0.4 3.0 1.9 2.0 0.7 1.8
Number of self-reported non-cancer illnesses 0.3 0.6 2.4 0.3 0.8 0.4 0.1 0.3 0.2 -1.5 -0.6 0.5 -0.6 1.1 -1.3 -0.7 -0.3 0.4 -0.4 0.3 -1.3 0.3 -0.8 0.6 -0.3 -0.3 -0.9 -1.5
Average weekly champagne plus white wine intake 0.2 0.3 1.6 -0.3 -0.2 -0.1 -0.1 -0.3 -0.2 1.1 0.0 -0.0 0.3 0.0 -0.6 0.1 -0.6 0.2 0.5 -0.1 -1.3 0.2 0.6 -0.6 -0.6 -0.7 -0.5 -1.3
Miserableness 2.3 4.0 9.4 2.2 2.6 2.2 1.9 2.1 2.0 -3.1 -2.5 2.3 1.1 2.7 0.6 -2.5 1.6 2.6 1.5 2.3 -0.0 2.3 0.6 2.0 1.9 2.0 1.1 0.4
Guilty feelings 0.3 0.5 1.8 -0.7 -0.3 -0.6 -0.8 -0.8 -0.8 0.3 0.6 -0.7 -1.2 -0.2 -0.8 0.4 -0.5 -0.7 -1.0 -0.7 -0.4 -0.8 -1.4 0.3 -0.4 -0.3 -0.8 -0.3
Wears glasses or contact lenses 0.4 0.4 1.1 -0.4 -0.3 -0.7 -0.7 -0.4 -0.5 -0.4 0.4 -0.6 -0.9 -0.9 -1.0 0.8 -0.6 -0.2 -1.1 -0.5 -0.4 -0.5 -1.0 -0.6 -0.7 -0.3 -0.4 -0.6
Ever taken oral contraceptive pill 1.0 1.1 2.8 0.6 0.8 1.0 0.8 0.6 0.6 0.5 -0.9 0.8 1.5 0.7 1.5 -0.8 1.3 0.9 0.8 1.1 1.7 1.1 0.9 0.7 1.2 1.1 1.6 1.7
Hearing aid user 0.8 0.9 3.2 -0.9 -0.7 -0.9 -1.1 -0.9 -1.0 0.4 0.6 -0.7 -1.6 -0.9 -1.2 0.8 -0.9 -0.6 -0.9 -0.7 -0.7 -0.8 -1.8 0.1 -0.9 -0.8 -1.0 -0.8
Mother’s age at death 0.5 0.6 2.0 -0.8 -0.6 -1.0 -0.8 -0.7 -0.7 1.4 0.7 -0.8 -1.0 -1.0 -0.3 1.0 -0.5 -0.9 -0.8 -0.9 0.3 -0.7 -0.2 -1.4 -0.6 -0.8 -0.4 -0.1
Financial situation satisfaction 1.8 2.2 4.2 1.6 1.8 1.8 1.6 1.6 1.5 -2.1 -1.7 1.6 1.5 2.0 0.8 -2.0 1.4 1.6 1.1 1.5 0.5 1.7 1.3 0.9 1.4 1.2 0.7 0.3
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.7 0.3 0.2 0.2 0.1 0.3 0.3 0.3 -0.3 0.2 -0.0 -0.0 -0.7 -0.5 -0.2 0.6 0.0 0.4 -0.7 0.5 -0.1 0.5 -0.3 -0.1 -0.5 -0.8
Commuting to job workplace: Public transport 0.8 1.0 2.7 -0.7 -0.1 -0.6 -1.0 -0.7 -0.8 -0.4 0.2 -0.8 -1.3 -0.6 -1.7 0.6 -1.1 -0.4 -1.1 -0.9 -1.4 -0.7 -1.1 -1.4 -1.1 -1.2 -1.1 -1.4
Eye problems/disorders: Glaucoma 0.3 0.3 1.8 -0.3 -0.3 -0.6 -0.4 -0.3 -0.4 -0.4 0.5 -0.3 -0.5 0.3 -0.7 0.4 -0.6 0.0 -1.3 -0.2 -0.7 0.3 -0.4 -0.9 -0.5 -0.8 -0.7 -0.6
Medication: Blood pressure 0.2 0.4 1.9 -0.5 -0.4 -0.4 -0.6 -0.6 -0.6 -0.3 0.4 -0.4 -0.9 -0.2 -1.0 0.1 -0.6 -0.6 -0.4 -0.3 -1.0 -0.6 -1.4 0.2 -0.5 -0.5 -0.8 -1.0
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.1 -0.8 -0.7 -0.8 -0.8 -0.8 -0.8 0.7 0.9 -0.9 -1.0 -0.7 -1.1 0.6 -1.1 -1.4 -0.3 -0.9 -1.4 -1.2 -1.1 -0.4 -1.0 -1.2 -1.2 -1.3
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.9 -1.1 -1.1 -1.0 -1.1 -1.1 -1.1 0.0 1.1 -1.1 -0.7 -1.1 -0.6 1.0 -0.8 -1.0 -1.4 -0.9 -0.1 -1.0 -0.9 -1.0 -0.8 -0.6 -0.4 -0.2
High cholesterol (Self-reported) 0.6 1.0 2.7 0.7 0.7 1.2 1.1 0.7 0.8 -0.3 -0.7 0.8 1.4 1.2 1.2 -1.0 1.1 0.9 1.2 1.0 0.6 1.2 1.6 1.4 1.0 0.8 0.6 0.5
Medication: Bendroflumethiazide 0.6 0.9 2.5 0.9 1.0 0.7 0.5 0.9 0.8 -1.6 -0.7 0.9 -0.6 1.1 0.5 -0.9 1.0 0.5 -0.6 1.0 1.4 0.4 -1.1 0.6 1.1 1.3 1.1 1.4
Medication: Paracetamol 0.0 0.1 0.5 0.0 -0.0 -0.2 0.2 -0.1 0.0 0.3 0.3 -0.1 -0.1 -0.1 0.3 -0.0 0.1 -0.7 -0.1 -0.2 -0.0 -0.3 0.2 0.3 0.1 -0.1 -0.3 0.0
Medication: Lisinopril 0.6 0.7 1.4 -1.1 -0.9 -1.0 -1.1 -1.1 -1.1 0.5 1.0 -1.0 -0.8 -1.2 -0.7 1.0 -0.7 -0.6 -0.9 -1.0 -0.1 -0.8 -0.8 -0.3 -0.9 -0.6 -0.8 -0.3
Medication: Atorvastatin 0.2 0.2 0.7 -0.1 -0.2 0.4 0.2 -0.2 -0.1 0.1 0.1 0.0 0.2 0.8 0.9 -0.3 0.6 0.2 0.5 0.3 0.9 0.4 0.6 0.3 0.5 0.4 0.7 0.8
Illnesses of father: High blood pressure 2.2 2.7 4.9 -2.0 -1.9 -1.9 -1.9 -1.9 -1.9 1.0 2.0 -1.9 -1.4 -2.2 -1.0 2.2 -1.6 -1.8 -1.6 -1.8 -0.5 -1.9 -1.4 -1.5 -1.6 -1.4 -1.0 -0.4
Alcohol drinker status: Never 0.8 0.9 2.0 1.0 1.0 1.4 1.0 1.0 1.0 -0.7 -1.1 1.0 0.9 1.4 0.6 -1.2 0.7 1.0 1.2 1.0 -0.2 1.0 0.8 1.2 0.9 0.8 0.4 0.1
Ever smoked 1.4 2.5 5.1 1.7 1.7 1.6 1.8 1.7 1.7 0.3 -1.8 1.7 1.9 1.6 1.5 -1.9 1.5 1.8 0.7 1.8 0.5 2.1 1.7 2.2 1.7 1.3 0.7 1.0
Basal metabolic rate 0.9 5.1 9.1 2.2 2.2 2.6 2.2 2.2 2.2 -2.2 -2.3 2.3 1.7 2.8 2.2 -2.9 2.4 2.1 0.8 2.6 1.9 2.2 0.6 3.0 2.7 2.6 1.6 2.5
Leg fat percentage (left) 0.2 0.6 6.2 0.1 0.6 0.5 0.2 0.1 0.1 -0.0 -0.4 0.2 -0.0 0.2 -0.5 -0.9 -0.2 0.2 -0.3 0.3 -1.3 0.2 -0.9 2.5 0.1 0.2 -1.6 -0.8
Arm fat-free mass (left) 1.1 5.3 8.7 2.3 2.4 2.7 2.4 2.3 2.3 -2.4 -2.4 2.4 2.1 2.9 2.1 -2.9 2.3 2.4 1.1 2.7 1.5 2.5 1.1 3.0 2.6 2.5 1.4 2.1
Number of operations (self-reported) 0.6 0.9 2.4 -0.7 -0.5 -0.7 -0.8 -0.8 -0.8 1.5 0.6 -0.7 -1.0 -0.8 -1.4 0.3 -1.0 -1.0 -0.3 -0.8 -1.4 -1.1 -1.4 -0.3 -0.9 -1.0 -0.9 -1.4
Average weekly beer plus cider intake 1.4 2.0 3.9 1.5 1.3 1.5 1.6 1.5 1.6 -1.3 -1.4 1.4 1.8 1.5 1.4 -1.5 1.2 1.4 1.3 1.5 0.6 1.6 2.0 1.8 1.3 1.2 1.0 0.9
Irritability 1.4 2.4 5.2 1.4 1.4 1.8 1.4 1.4 1.4 -1.7 -1.5 1.6 1.2 1.5 1.2 -1.6 1.6 1.8 0.6 2.0 1.3 1.8 0.5 2.3 1.6 2.0 1.3 1.4
Risk taking 0.3 0.5 1.9 0.7 0.8 0.2 0.4 0.7 0.6 -1.3 -0.7 0.7 -0.2 0.6 -1.0 -0.6 -0.3 0.7 -0.0 0.5 -1.4 0.7 -0.3 -0.3 -0.1 -0.5 -0.4 -1.2
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.7 -0.2 -0.4 -0.1 -0.1 -0.1 -0.1 1.2 0.0 -0.1 0.3 -0.2 -0.6 0.4 -0.5 0.5 0.5 -0.0 -1.0 0.4 0.7 0.4 -0.6 -0.5 -0.6 -1.3
Fractured/broken bones in last 5 years 1.9 2.5 5.7 2.0 1.7 1.8 1.9 2.0 2.1 0.3 -1.8 1.9 1.5 1.7 0.8 -1.9 1.2 1.7 2.4 1.6 0.0 1.5 1.6 1.3 1.3 1.0 1.0 0.1
Age started oral contraceptive pill 3.2 4.0 11.0 2.4 2.5 2.2 2.4 2.4 2.5 -0.2 -2.4 2.4 2.3 1.9 1.5 -1.7 1.8 2.0 3.3 1.9 0.6 1.8 2.6 1.1 1.6 1.6 1.5 0.4
Diastolic blood pressure, automated reading 0.4 1.2 3.5 -1.2 -0.7 -0.9 -1.2 -1.2 -1.3 0.8 1.0 -1.3 -1.1 -1.1 -1.3 0.5 -1.1 -1.0 -1.1 -0.8 -0.9 -1.2 -1.9 0.4 -1.2 -0.7 -1.4 -1.0
Ever depressed for a whole week 1.4 1.8 3.1 1.2 1.3 1.4 1.4 1.2 1.2 -1.2 -1.1 1.3 1.5 1.5 1.2 -1.6 1.2 1.3 1.8 1.7 0.4 1.4 1.4 1.5 1.3 1.5 1.3 0.7
Unable to work because of sickness or disability 2.3 2.9 4.6 1.6 2.1 1.7 1.5 1.6 1.5 -2.0 -1.9 1.6 1.6 1.8 1.5 -1.9 1.9 1.9 1.0 1.8 1.8 1.8 0.6 1.4 2.0 2.0 1.7 1.8
Commuting to job workplace: Cycle 0.3 0.4 1.7 -0.3 -0.7 -0.5 -0.6 -0.3 -0.3 0.1 0.6 -0.3 -1.3 -0.5 -0.8 0.3 -0.4 -0.7 -1.2 -0.4 -0.0 -0.5 -1.3 -0.8 -0.4 -0.5 -0.3 -0.3
Myopia 0.5 0.7 1.6 1.1 0.9 0.6 0.8 1.1 1.1 -1.2 -0.8 1.0 -0.1 1.1 0.5 -0.7 1.0 0.5 -0.3 0.6 1.3 0.3 -0.3 0.4 1.0 1.0 0.6 1.0
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.9 0.6 0.1 0.5 0.7 0.6 0.7 0.5 -0.4 0.5 1.1 0.1 1.6 -0.1 1.0 0.4 0.8 0.5 1.6 0.4 1.2 0.5 1.0 1.0 1.3 1.7
Cholesterol lowering medication 0.6 0.9 2.5 0.6 0.8 1.0 1.0 0.6 0.7 0.2 -0.7 0.6 1.4 0.5 1.5 -0.8 1.1 0.5 1.2 0.7 1.0 0.7 1.5 1.6 0.9 1.1 0.7 1.0
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.5 1.2 1.4 1.3 1.3 1.1 1.2 -1.1 -1.1 1.1 0.6 1.3 0.8 -1.4 1.2 1.0 1.6 1.3 0.5 1.0 0.9 0.7 1.2 1.1 1.2 0.3
Pain experienced in last month 0.1 0.2 1.2 -0.3 -0.6 -0.7 -0.3 -0.2 -0.2 0.7 0.4 -0.3 -0.0 -1.1 0.1 0.7 -0.2 0.1 0.2 -0.3 0.5 -0.3 0.2 -0.9 -0.3 0.0 0.7 0.4
Supplements: Calcium 0.7 0.7 1.4 -1.0 -0.6 -0.9 -1.1 -0.9 -1.0 1.2 0.5 -0.9 -0.8 -1.2 -0.9 1.0 -0.8 -0.7 -0.7 -1.1 -0.4 -0.8 -0.6 -0.6 -0.9 -1.0 -0.7 -0.6
Basal cell carcinoma (self-reported) 0.5 0.6 1.4 0.4 0.5 0.9 0.7 0.4 0.5 0.3 -0.4 0.4 0.8 0.4 1.2 -0.8 1.0 0.4 1.1 0.7 1.0 0.5 0.7 1.2 0.9 0.9 0.7 0.8
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.0 -0.8 -0.9 -0.7 -0.5 -0.8 -0.7 -0.5 1.0 -0.7 0.0 -0.3 -0.1 1.0 -0.7 -0.2 -0.2 -0.7 -0.6 -0.2 0.7 -0.3 -0.8 -0.8 -0.9 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.5 -0.2 0.1 0.0 0.1 -0.2 -0.1 0.9 -0.1 -0.2 0.7 0.0 -0.2 -0.1 -0.4 0.1 1.2 -0.1 -0.9 0.2 1.1 -0.1 -0.5 -0.7 -0.4 -1.1
Heart disease (siblings) 2.6 3.1 5.3 2.0 1.8 2.0 1.9 1.9 2.0 -1.8 -1.8 1.9 1.7 2.0 1.1 -2.3 1.8 2.2 1.6 2.0 0.8 2.2 1.5 1.2 1.8 1.7 1.4 0.7
Alcohol drinker status: Previous 0.2 0.3 0.9 0.4 0.2 0.5 0.5 0.4 0.4 -0.0 -0.4 0.3 0.9 0.9 0.7 -0.3 0.5 0.4 0.8 0.4 0.4 0.4 0.8 0.6 0.4 0.3 0.4 0.4
Pack years of smoking 2.4 3.5 5.5 2.0 2.0 2.2 2.0 2.0 2.0 -2.3 -2.1 2.1 1.6 2.3 1.6 -2.2 1.8 1.9 1.9 2.0 0.7 1.9 1.7 1.1 1.9 1.8 1.7 1.1
Impedance of whole body 0.3 1.4 5.0 -0.7 -0.4 -1.2 -0.8 -0.7 -0.7 1.3 0.6 -0.8 -0.6 -1.4 -1.6 1.3 -1.4 -0.9 1.0 -1.2 -1.7 -1.4 -0.0 -1.0 -1.6 -1.2 -0.9 -2.2
Leg fat mass (left) 0.4 1.5 9.4 1.1 1.4 1.5 1.1 1.1 1.1 -0.9 -1.3 1.2 0.7 1.4 0.6 -1.9 1.0 1.2 -0.1 1.4 0.0 1.3 -0.2 3.1 1.2 1.3 -0.4 0.6
Arm predicted mass (left) 1.1 5.4 10.0 2.4 2.4 2.7 2.4 2.3 2.3 -2.3 -2.4 2.4 2.2 2.8 2.1 -2.9 2.2 2.4 1.1 2.7 1.3 2.5 1.1 3.2 2.5 2.5 1.3 2.0