Hub : Genes

DEDD

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0195 0.0083 0.00270 0.007 0.007 0.007 0.008 0.008 0.00200 0.0016 0.0025 0.0013 0.00093
2 TCGA Kidney Renal Papillary Cell Carcinoma 0.0880 0.0460 0.00073 0.008 0.047 0.004 NA 0.016 0.11000 0.0010 0.1900 NA 0.03800
3 TCGA Brain Lower Grade Glioma 0.0203 0.0111 0.00240 0.032 0.016 0.019 NA 0.027 0.00013 0.0052 0.0029 NA 0.00042

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.2 3.5 6.2 2.5 -1.3 -1.6
Bipolar Disorder or Schizophrenia 1.2 3.0 4.9 2.2 -1.3 -1.5
Depressed Affect (Nagel 2018) 0.1 0.1 0.2 -0.4 0.4 -0.2
Depression (Nagel 2018) 1.4 2.1 3.6 -1.9 1.0 1.3
Intelligence (Savage-Jansen 2018) 0.8 2.4 6.3 0.6 -2.5 -0.7
Neuroticism (Nagel 2018) 0.2 0.4 0.6 0.6 -0.5 -0.8
Schizophrenia (2018) 0.3 0.5 0.7 0.8 -0.7 -0.6
Schizophrenia vs Biploar Disorder 3.5 4.6 5.9 -1.6 2.3 2.4
Worry (Nagel 2018) 0.4 0.9 1.5 0.6 -0.9 -1.2
Alzheimer’s Disease (in mother) 2.4 2.8 6.6 1.2 -0.6 -2.6
Alzheimer’s Disease (in father) 3.3 3.6 4.8 2.0 -1.4 -2.2
Alzheimer’s Disease (including proxy) 4.8 6.9 15.2 1.8 -1.5 -3.9
Crohns Disease (2017) 2.0 4.3 9.9 -0.6 3.1 1.7
Irritable Bowel Disease (IBD) 1.4 3.2 9.0 0.0 3.0 0.9
Ulcerative Colitis (UC) 0.5 1.0 2.3 0.7 1.5 -0.5
Major Depression (MDD) 0.3 0.3 0.5 -0.7 -0.7 -0.1
Reaction Time 1.1 2.2 3.6 1.3 -1.9 -1.1
Verbal and Numeric Reasoning (VNR) 2.1 5.1 11.7 1.2 -3.4 -1.4
Breast Cancer 0.3 0.6 1.6 -0.4 -1.3 0.3
Ovarian Cancer 2.2 3.0 4.6 -0.7 2.1 2.0
Prostate Cancer 0.1 0.2 0.2 -0.4 0.5 0.3
Age at First Birth 1.4 2.1 3.0 1.2 -1.4 -1.7
Bipolar Disorder (2011) 0.7 0.7 1.0 1.0 -0.5 -1.0
Body Mass Index (BMI) (2010) 0.8 1.1 1.4 -1.1 0.8 1.2
Coronary Artery Disease (CAD) 1.7 2.0 2.2 1.5 -1.3 -1.4
Crohns Disease (2012) 1.2 2.0 4.3 -0.7 2.1 1.1
Mean Putamen Volume 0.7 0.8 1.5 -1.0 0.2 1.2
Fasting Glucose 0.3 0.4 0.6 0.7 -0.7 -0.4
HbA1C 1.5 1.7 2.7 0.8 1.7 1.3
HDL Cholesterol 2.1 3.5 4.5 1.6 -2.1 -1.9
LDL Cholesterol 0.1 0.2 0.5 -0.2 0.7 -0.1
Lupus 1.0 1.6 4.6 -0.1 -0.4 -2.1
Neuroticism (2016) 0.1 0.1 0.2 0.5 -0.1 -0.3
Primary Biliary Cirrhosis 0.3 0.4 0.9 -1.0 -0.4 0.3
Rheumatoid Arthritis 0.7 1.0 2.5 0.4 1.6 0.5
Schizophrenia (2014) 0.1 0.2 0.4 0.7 0.0 -0.3
Triglycerides 1.8 3.0 4.2 -1.6 2.1 1.5
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.3 0.2 0.6 -0.3
Ulcerative Colitis 0.1 0.2 0.3 0.1 0.5 0.6
Blood Eosinophil Count 0.5 4.2 12.1 0.6 -0.1 3.5
Blood Platelet Count 0.2 2.4 4.0 1.0 1.5 -2.0
Blood Red Count 1.0 9.3 15.4 -2.3 2.6 3.9
Blood White Count 3.4 25.3 42.5 -4.1 4.1 6.5
Heel T-Score 0.1 0.9 1.0 0.9 1.0 -1.0
BMI 1.8 10.2 19.7 -4.4 1.7 2.8
Height 0.0 0.5 1.1 -1.1 0.3 -0.4
Waist Hip Ratio (WHR) 2.2 9.9 14.3 3.4 -2.1 -3.8
Systolic Blood Pressure 0.5 2.6 6.0 -2.4 0.6 1.2
Smoking Status 0.2 0.5 1.1 0.3 -1.0 -0.6
Allergy or Eczema 1.6 4.2 10.8 3.3 0.3 1.3
Cardiovascular Disease 0.6 2.1 2.6 -1.6 1.3 1.4
Hypothyroidism (self reported) 0.1 0.3 0.8 -0.9 0.2 -0.3
Respiratory disease 1.5 3.3 6.8 0.3 2.6 1.7
Type 2 Diabetes (T2D) (2018) 1.5 2.9 3.8 -1.9 1.9 1.2
Lung FEV1/FVC ratio 0.1 0.4 1.2 -0.0 -1.1 0.3
Lung FVC 0.4 1.9 5.4 0.5 -2.3 0.3
Neuroticism 0.0 0.1 0.2 -0.1 0.4 -0.4
Chronotype (morning person) 0.4 1.0 2.9 1.7 0.1 -0.1
Hair Pigment 0.0 0.0 0.1 -0.3 0.1 -0.2
Tanning 0.1 1.2 3.1 -0.7 -0.2 1.8
Hand grip strength (left) 2.1 5.5 10.4 -1.7 1.8 3.2
Number of treatments/medications taken 0.7 1.3 2.2 -0.6 1.5 1.2
Average weekly spirits intake 0.8 1.0 1.8 1.4 -0.7 -0.9
Sensitivity / hurt feelings 0.2 0.4 0.9 0.4 -0.9 -0.5
Frequency of depressed mood in last 2 weeks 2.3 3.2 4.8 -2.2 1.6 1.5
Hearing difficulty/problems: Yes 1.3 2.0 3.7 -1.9 0.6 1.4
Relative age of first facial hair 0.2 0.4 0.5 -0.2 0.7 0.7
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 3.1 -1.4 1.8 0.7
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.8 -1.4 0.4 0.9
Ever had hysterectomy (womb removed) 0.9 1.0 2.7 -0.3 -1.6 -0.4
Systolic blood pressure, automated reading 0.8 2.4 6.9 -2.6 0.4 0.5
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 4.5 -2.1 1.9 1.2
Angina 0.4 0.6 1.3 0.4 1.1 -0.5
Medication for hormone replacement therapy 0.6 0.7 1.0 0.9 1.0 0.4
Vitamin and mineral supplements 1.8 2.4 4.1 0.8 -1.6 -2.0
Supplements: Zinc 1.9 2.1 3.6 -1.4 1.9 0.8
Medication: Co-codamol 2.7 3.2 5.2 -2.3 1.7 1.2
Medication: Metformin 2.1 3.0 4.9 -1.7 2.2 1.1
Diabetes (father) 0.1 0.1 0.4 -0.1 0.1 -0.6
Diabetes (mother) 1.0 1.3 2.9 0.8 -0.5 -1.7
Severe depression (siblings) 1.3 1.5 2.6 1.6 -0.8 -1.1
Pack years adult smoking proportion 0.4 0.7 1.8 -0.4 0.3 -1.3
Impedance of leg (right) 0.2 0.9 1.4 1.2 -1.0 0.5
Leg fat-free mass (left) 0.6 3.1 6.4 -2.5 1.7 0.0
Trunk fat percentage 2.3 9.3 16.8 -4.1 2.0 2.7
Hand grip strength (right) 2.6 7.2 11.6 -2.3 2.1 3.4
Townsend deprivation index at recruitment 1.1 1.5 1.9 -1.2 1.4 1.1
Current tobacco smoking 0.1 0.2 0.5 0.5 -0.1 -0.7
Average weekly fortified wine intake 1.1 1.3 2.2 1.2 -0.4 -1.5
Maternal smoking around birth 0.1 0.1 0.2 0.5 0.2 -0.3
Fed-up feelings 0.1 0.1 0.4 -0.0 -0.0 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 3.0 4.0 5.6 -2.4 1.8 1.8
Relative age voice broke 0.1 0.2 0.2 -0.4 0.5 -0.3
Taking other prescription medications 0.6 0.9 2.0 -0.3 0.8 1.4
Age when periods started (menarche) 0.4 0.9 2.5 0.3 1.6 0.1
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.5 -0.1 -0.7 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 4.8 -0.3 2.2 0.6
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.1 -0.0 -1.0 -1.1
Qualifications: CSEs or equivalent 0.1 0.2 0.4 -0.2 0.7 0.2
Serious illness, injury or assault to yourself 0.7 0.8 1.2 -0.3 1.1 1.1
High blood pressure 0.7 2.1 4.0 -2.0 1.5 0.2
Hayfever, allergic rhinitis or eczema 1.3 2.9 5.0 2.2 1.1 1.6
Multivitamins +/- minerals 2.4 3.1 7.2 -0.5 1.4 2.7
Stomach or abdominal pain in last month 1.6 2.0 3.3 -0.4 1.6 1.8
Supplements: Glucosamine 0.1 0.2 0.5 0.7 -0.3 -0.1
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.0 0.0 0.4 1.0
Medication: Atenolol 2.4 3.0 6.5 -1.2 2.6 1.0
Medication: Levothyroxine sodium 2.4 4.1 7.3 -2.7 2.1 0.9
Sitting height 0.1 0.4 0.9 -0.7 -0.1 -0.9
Chronic bronchitis/emphysema (father) 0.6 0.7 1.5 1.2 -0.7 -0.3
High blood pressure (mother) 0.2 0.2 0.6 -0.8 -0.3 0.0
Body mass index (BMI) 1.5 6.4 11.6 -3.4 2.2 1.6
Impedance of leg (left) 0.3 1.4 2.7 1.6 -1.2 0.3
Leg predicted mass (left) 0.6 3.2 6.6 -2.6 1.8 0.1
Trunk fat mass 2.4 10.1 18.1 -4.3 2.5 2.5
Waist circumference 0.8 3.1 7.1 -2.7 1.4 0.4
Number of incorrect matches in round 1.5 2.5 4.9 -1.1 1.2 2.2
Past tobacco smoking 0.4 0.8 1.4 1.2 -0.8 -0.5
Alcohol usually taken with meals 1.9 3.0 5.9 2.4 -1.2 -1.3
Nervous feelings 0.1 0.3 0.8 0.3 -0.1 -0.9
Frequency of tenseness / restlessness in last 2 weeks 2.9 4.5 6.6 -2.6 1.6 2.1
Hearing difficulty/problems with background noise 0.7 1.1 2.0 -0.8 1.4 0.7
Hair/balding pattern: Pattern 2 0.5 0.7 2.0 -1.4 -0.0 0.2
Had menopause 0.3 0.4 0.6 0.7 0.3 -0.8
Had other major operations 1.5 1.8 2.5 -1.4 1.6 0.9
Forced vital capacity (FVC) 0.3 1.2 1.7 -1.3 0.4 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 4.1 -0.2 2.0 0.9
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.6 -0.5 1.3 0.9
Qualifications: None of the above 0.2 0.4 1.0 -1.0 0.1 0.3
Financial difficulties in last 2 years 1.5 2.1 3.4 -1.8 1.7 -0.0
Mouth/teeth dental problems 4.7 7.2 17.5 -4.2 0.8 1.9
Heart attack 0.5 0.6 0.9 -0.2 0.9 0.9
Allergy 1.5 3.3 4.6 -2.2 -1.6 -1.6
Pain all over the body in last month 5.2 5.6 9.1 -3.0 2.2 1.7
Diabetes (self-reported) 2.6 4.0 5.1 -2.2 1.8 1.9
Hayfever/allergic rhinitis (self-reported) 2.3 3.0 6.7 2.6 1.2 1.0
Medication: Ramipril 0.9 1.2 1.7 -1.3 -0.5 1.3
Medication: Simvastatin 2.4 3.5 5.2 -1.7 1.6 2.3
Fluid intelligence score 3.5 7.3 15.2 1.7 -3.9 -1.9
Illnesses of siblings 2.7 3.7 7.0 2.6 -1.4 -1.4
Neuroticism score 0.1 0.1 0.3 -0.1 -0.5 -0.2
Weight 1.5 7.1 13.2 -3.6 2.5 1.4
Impedance of arm (right) 0.1 0.3 0.9 -0.0 -0.3 0.9
Arm fat percentage (right) 2.3 9.1 15.4 -3.9 2.2 2.7
Trunk fat-free mass 0.3 1.8 2.8 -1.5 1.7 -0.5
Hip circumference 2.2 9.4 16.2 -4.0 2.8 2.1
Time employed in main current job 0.8 1.0 1.4 -1.2 0.7 1.0
Alcohol intake versus 10 years previously 1.3 2.0 2.5 -1.4 1.2 1.6
Father’s age at death 2.6 3.5 5.1 2.3 -1.7 -1.6
Worrier / anxious feelings 0.3 0.6 1.7 0.4 -1.3 -0.2
Frequency of tiredness / lethargy in last 2 weeks 2.5 4.1 5.5 -2.4 1.4 2.2
Falls in the last year 0.3 0.4 1.0 -0.2 1.0 0.5
Hair/balding pattern: Pattern 3 0.4 0.6 1.3 1.1 -0.3 -0.7
Number of live births 0.2 0.2 0.6 0.1 -0.2 -0.8
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 1.6 -1.3 0.3 1.2
Pulse rate 0.5 0.9 1.9 -0.5 1.4 0.7
Happiness 0.5 0.6 1.0 -1.0 0.6 0.6
Noisy workplace 3.8 4.6 6.0 -2.4 1.5 2.4
Qualifications: A levels/AS levels or equivalent 2.3 5.0 6.4 2.5 -1.7 -2.4
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 -0.2 -0.3 -0.1
Mouth/teeth dental problems: Dentures 0.8 1.4 2.3 1.0 0.9 1.5
Asthma 2.2 4.3 7.8 0.3 2.8 2.3
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 3.1 -1.8 1.1 1.3
Medication: Cholesterol lowering 1.0 1.6 2.7 -0.7 1.2 1.6
Depression (self-reported) 0.4 0.5 1.1 -0.4 0.5 1.0
Medication: Lansoprazole 0.2 0.2 0.5 0.3 -0.7 -0.2
Prospective memory result 1.5 1.9 2.7 -1.0 1.7 1.4
Lung cancer (father) 0.1 0.1 0.3 0.2 -0.5 -0.1
Illnesses of mother 0.4 0.4 1.2 0.2 -0.3 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.7 -1.3 0.3 0.9
Pulse wave Arterial Stiffness index 0.4 0.5 1.4 -0.3 1.2 -0.0
Impedance of arm (left) 0.1 0.4 1.0 -0.2 -0.5 1.0
Arm fat mass (right) 2.0 8.2 15.4 -3.9 2.2 2.1
Trunk predicted mass 0.3 1.8 2.8 -1.5 1.7 -0.5
Standing height 0.0 0.3 0.4 -0.6 0.4 -0.6
Length of working week for main job 1.2 1.3 2.5 -0.9 0.8 1.6
Exposure to tobacco smoke at home 2.4 2.7 4.0 -2.0 0.7 1.9
Breastfed as a baby 1.2 1.4 3.8 -2.0 0.3 0.6
Tense / ‘highly strung’ 0.6 1.0 2.5 -1.6 0.6 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.7 0.9 -0.5 -0.4
Hair/balding pattern: Pattern 4 0.3 0.6 1.3 0.6 -1.2 0.5
Birth weight of first child 1.4 2.6 3.3 1.8 -1.2 -1.8
Peak expiratory flow (PEF) 0.2 0.4 0.8 0.9 -0.4 0.5
Pulse wave reflection index 0.1 0.1 0.1 -0.3 0.1 -0.3
Ever highly irritable/argumentative for 2 days 0.0 0.1 0.1 -0.3 0.2 0.1
Loud music exposure frequency 0.1 0.1 0.4 0.2 -0.1 -0.6
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.5 -0.6 -0.9 -1.2
Mouth/teeth dental problems: Bleeding gums 2.7 3.5 5.1 2.3 -1.4 -1.9
Blood clot in the leg (DVT) 0.6 0.7 1.0 0.7 -1.0 -0.8
Medication: Paracetamol 4.0 6.6 11.8 -3.4 2.0 2.0
Headache pain in last month 3.7 6.3 7.6 -2.6 2.8 2.1
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 2.6 1.6 -1.5 -1.3
Glaucoma (self-reported) 0.1 0.2 0.2 -0.3 0.5 0.4
Gout (self-reported) 0.3 0.5 1.3 0.2 1.1 0.2
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 2.5 -1.6 0.5 0.2
Medication: Amlodipine 2.2 3.1 6.0 -1.5 2.5 1.1
Medication: Ventolin 100micrograms inhaler 4.3 5.6 11.2 -0.5 3.3 2.3
Birth weight 2.4 5.2 6.5 -2.5 2.2 2.0
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 -0.5 -0.2 0.6
High blood pressure (siblings) 2.9 4.2 7.2 -2.7 1.7 1.6
Forced vital capacity (FVC), Best measure 0.4 1.3 2.2 -1.5 0.4 1.2
Body fat percentage 2.5 9.9 16.5 -4.1 2.5 2.7
Leg fat percentage (right) 2.0 7.1 10.2 -3.2 2.5 2.2
Arm fat-free mass (right) 0.3 1.7 3.1 -1.8 1.4 -0.4
Exposure to tobacco smoke outside home 0.2 0.3 0.8 -0.3 -0.9 -0.2
Comparative body size at age 10 1.4 3.8 6.2 -2.5 0.4 2.2
Number of full brothers 0.0 0.1 0.1 0.2 -0.4 -0.0
Worry too long after embarrassment 1.6 2.7 3.9 1.0 -1.8 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 3.5 1.6 -0.8 -1.9
Wheeze or whistling in the chest in last year 1.0 1.8 2.9 -0.4 1.7 1.5
Number of children fathered 5.2 5.8 7.6 -2.3 2.8 2.2
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.5 -1.2 -1.0 0.2
Age at first live birth 3.6 6.3 9.2 3.0 -2.6 -1.7
Pulse wave peak to peak time 0.4 0.5 1.4 0.3 -1.2 -0.1
Health satisfaction 3.5 4.6 7.9 -2.8 2.0 1.3
Shortness of breath walking on level ground 3.1 3.7 7.6 -1.5 2.8 1.1
Qualifications: College or University degree 0.7 2.1 5.7 2.4 -0.4 -0.6
Eye problems/disorders: None of the above 0.6 0.7 2.0 0.2 -1.4 -0.3
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.7 0.7 0.9 1.3
Emphysema/chronic bronchitis 0.4 0.5 0.8 -0.1 -0.8 -0.9
Medication for pain relief, constipation, heartburn 2.5 4.3 6.4 2.5 -1.6 -2.0
Neck or shoulder pain in last month 0.4 0.6 1.2 -0.3 1.1 0.7
Medication: Blood pressure 1.9 3.3 4.4 -2.1 2.1 1.1
Angina (self-reported) 0.4 0.5 1.1 0.2 1.1 -0.5
Migraine (self-reported) 0.5 0.6 0.9 -0.9 1.0 -0.4
Medication: Ibuprofen 1.7 2.1 3.5 -1.9 1.2 1.1
Medication: Allopurinol 0.1 0.1 0.1 0.3 0.2 0.3
Medication: Omeprazole 1.0 1.2 3.1 -0.6 1.8 0.3
Medication: Seretide 50 evohaler 2.8 3.3 4.6 -1.2 1.9 2.2
Mean time to correctly identify matches 1.9 3.6 4.5 2.1 -2.1 -1.4
Heart disease (mother) 0.3 0.4 0.6 -0.2 -0.7 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 0.9 -0.9 0.8 0.3
Whole body fat mass 2.1 8.9 15.9 -4.0 2.5 2.1
Leg fat mass (right) 2.0 7.6 12.6 -3.5 2.6 1.9
Arm predicted mass (right) 0.4 2.0 3.3 -1.8 1.6 -0.3
Pulse rate, automated reading 0.1 0.4 0.7 -0.7 0.8 0.3
Alcohol intake frequency. 0.7 1.7 2.4 -1.0 1.5 1.3
Comparative height size at age 10 0.2 0.9 2.7 -1.6 0.2 0.3
Number of full sisters 4.2 5.1 8.4 -2.9 2.2 1.4
Suffer from ‘nerves’ 0.1 0.2 0.6 -0.8 -0.0 -0.3
Overall health rating 6.1 13.1 17.9 -4.2 3.8 2.7
Chest pain or discomfort 0.5 0.7 1.1 -0.8 1.0 -0.6
Had major operations 0.6 0.7 0.9 -1.0 0.8 0.7
Age at last live birth 2.9 4.2 6.3 2.5 -2.0 -1.6
Family relationship satisfaction 0.8 1.0 2.8 -1.7 -0.1 0.5
Leg pain on walking 0.2 0.3 0.8 0.1 -0.1 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 0.1 -0.1 -0.5
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.1 -0.6 1.1 0.9
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 3.0 1.0 -1.7 -1.3
Medication: Aspirin 1.2 1.6 2.5 -0.5 1.6 1.4
Supplements: Vitamin C 2.2 2.6 4.0 -1.9 2.0 0.5
Knee pain experienced in last month 0.5 0.7 1.7 0.1 1.3 -0.7
Hypertension (Self-reported) 0.6 1.7 3.4 -1.9 1.2 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 3.0 6.0 -1.2 2.4 1.2
Illnesses of father: Heart disease 0.9 1.3 3.7 -0.1 1.9 0.3
Illnesses of siblings: Diabetes 2.5 3.0 7.8 -2.8 0.8 0.8
Smoking status: Previous 0.3 0.4 1.1 -0.4 1.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.5 -1.6 0.5 0.9
Whole body fat-free mass 0.4 2.3 4.0 -2.0 1.7 -0.3
Leg fat-free mass (right) 0.5 2.6 5.2 -2.3 1.6 -0.1
Arm fat percentage (left) 2.2 8.9 15.4 -3.9 2.2 2.6
Average weekly red wine intake 0.2 0.2 0.5 0.7 0.5 0.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.5 -0.1 -0.3 -0.7
Mood swings 0.3 0.5 1.0 -0.2 1.0 0.6
Loneliness, isolation 1.4 2.0 3.1 -1.8 1.6 0.4
Long-standing illness, disability or infirmity 4.2 6.4 8.7 -3.0 2.5 2.1
Ever had bowel cancer screening 0.1 0.1 0.3 -0.0 -0.5 -0.2
Diabetes diagnosed by doctor 1.4 2.3 3.7 -1.9 1.3 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 -0.4 0.1 0.5
Friendships satisfaction 0.2 0.2 0.7 -0.8 0.1 0.2
Qualifications: nursing, teaching 0.1 0.2 0.6 0.7 -0.2 -0.1
Commuting to job workplace: Walk 0.4 0.4 0.9 1.0 -0.5 -0.1
Eye problems/disorders: Cataract 0.3 0.4 0.9 0.5 0.9 -0.0
Mouth/teeth dental problems: Mouth ulcers 8.5 13.4 22.9 4.8 -1.5 -3.9
Medication for cholesterol 0.5 0.7 1.1 0.5 -1.0 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.8 0.2 0.1 1.3
Back pain experienced in last month 0.3 0.4 0.9 -0.2 1.0 -0.4
Mineral and other dietary supplements 1.1 1.5 2.5 -0.2 -1.4 -1.6
Breast cancer (self-reported) 2.7 3.2 5.3 2.3 -2.0 -0.5
Asthma (self-reported) 2.3 4.6 8.2 0.1 2.9 2.4
Osteoporosis (self-reported) 0.6 0.7 2.1 -1.4 -0.1 0.3
Osteoarthritis (self-reported) 3.3 4.3 6.5 -2.5 2.5 0.5
Medication: Aspirin 0.5 0.7 1.3 0.3 1.1 0.8
Medication: Gliclazide 1.0 1.1 3.0 -1.7 0.2 0.6
Illnesses of father: None of the above (group 1) 2.2 2.8 7.3 0.5 -2.7 -0.8
Smoking status: Current 0.0 0.0 0.1 0.2 0.0 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.2 -1.2 0.1 1.5
Whole body water mass 0.4 2.6 4.7 -2.2 1.7 -0.3
Leg predicted mass (right) 0.5 2.4 5.1 -2.3 1.5 -0.1
Arm fat mass (left) 2.1 8.8 17.1 -4.1 2.1 2.1
Number of self-reported non-cancer illnesses 0.1 0.2 0.4 0.3 0.6 -0.2
Average weekly champagne plus white wine intake 0.6 0.8 0.8 0.9 -0.9 -0.9
Miserableness 0.5 0.8 1.9 0.4 -1.4 -0.6
Guilty feelings 0.1 0.2 0.4 0.6 -0.5 0.2
Wears glasses or contact lenses 1.8 2.0 3.8 1.3 -0.7 -2.0
Ever taken oral contraceptive pill 0.6 0.7 2.1 0.1 -0.2 1.4
Hearing aid user 2.1 2.4 4.3 1.1 -1.2 -2.1
Mother’s age at death 0.2 0.3 0.8 0.2 0.9 0.2
Financial situation satisfaction 1.7 2.1 4.5 -2.1 1.2 0.7
Tinnitus: Yes, now most or all of the time 3.6 4.3 6.2 -2.2 1.4 2.5
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.5 -0.4 -0.1
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 0.4 0.7 -0.1
Medication: Blood pressure 0.3 0.6 1.2 -1.1 0.3 0.6
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.4 1.6 -0.0 -0.9
Supplements: Fish oil (including cod liver oil) 1.2 1.6 2.9 -0.0 1.7 1.4
High cholesterol (Self-reported) 1.5 2.6 3.2 -1.3 1.7 1.8
Medication: Bendroflumethiazide 1.2 1.8 2.4 -1.6 1.0 1.4
Medication: Paracetamol 2.3 3.6 5.4 -2.3 1.5 1.7
Medication: Lisinopril 0.7 1.0 1.6 1.3 -0.6 -1.0
Medication: Atorvastatin 0.4 0.5 1.0 0.4 1.0 0.7
Illnesses of father: High blood pressure 1.5 1.8 3.6 -1.9 0.9 1.1
Alcohol drinker status: Never 0.2 0.3 0.6 -0.8 0.3 -0.3
Ever smoked 0.1 0.2 0.5 -0.7 0.1 0.3
Basal metabolic rate 0.7 3.7 7.0 -2.6 2.0 0.3
Leg fat percentage (left) 1.7 6.0 8.9 -3.0 2.3 2.0
Arm fat-free mass (left) 0.6 3.0 6.1 -2.5 1.7 0.2
Number of operations (self-reported) 0.2 0.4 0.6 -0.8 0.2 0.7
Average weekly beer plus cider intake 0.7 1.0 2.7 -1.6 0.5 0.2
Irritability 1.0 1.7 2.0 -1.2 1.3 1.4
Risk taking 0.2 0.3 0.8 -0.9 0.2 0.0
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.3 1.1 -0.7 0.2
Fractured/broken bones in last 5 years 3.0 3.9 6.6 -1.6 2.6 1.6
Age started oral contraceptive pill 1.4 1.8 4.0 0.8 -0.9 -2.0
Diastolic blood pressure, automated reading 0.5 1.6 4.8 -2.2 -0.1 0.3
Ever depressed for a whole week 0.8 1.0 2.3 -0.8 1.5 0.4
Unable to work because of sickness or disability 1.0 1.2 2.3 -1.5 1.1 -0.3
Commuting to job workplace: Cycle 0.7 0.9 1.8 0.5 -1.4 -0.6
Myopia 0.5 0.7 1.6 -0.3 -1.3 0.5
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.0 1.4 -1.4 0.2
Cholesterol lowering medication 2.2 3.3 4.5 -1.3 2.1 1.9
Medication: Omeprazole (e.g. Zanprol) 1.3 1.5 3.1 -1.0 1.8 0.7
Pain experienced in last month 0.8 1.3 1.9 1.4 -1.4 -0.0
Supplements: Calcium 0.7 0.8 1.2 0.5 -1.1 -0.9
Basal cell carcinoma (self-reported) 0.2 0.3 0.7 -0.3 -0.2 0.9
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.3 0.0 0.5 0.5
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 0.8 0.5 -0.9 -0.6
Heart disease (siblings) 0.2 0.3 0.6 -0.8 0.1 0.5
Alcohol drinker status: Previous 0.5 0.6 1.5 0.2 -1.2 -0.5
Pack years of smoking 0.4 0.5 1.1 -0.5 0.5 -1.0
Impedance of whole body 0.1 0.7 1.1 0.4 -0.9 1.1
Leg fat mass (left) 1.7 6.7 11.4 -3.4 2.4 1.7
Arm predicted mass (left) 0.5 2.6 5.2 -2.3 1.7 0.0