TWAS hub - DENND5B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1230	0.0320	8.1e-07	0.104	0.050	0.081	0.084	0.095	1.4e-12	8.6e-07	4.3e-10	2.0e-10	1.2e-11
2	GTEx	Artery Tibial	0.0836	0.0333	3.6e-03	-0.003	NA	0.005	NA	0.004	7.4e-01	NA	1.1e-01	NA	1.4e-01
3	GTEx	Thyroid	0.1040	0.0400	7.3e-03	0.019	NA	0.001	NA	0.008	1.2e-02	NA	2.5e-01	NA	7.9e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.1882	0.0336	9.3e-15	0.093	0.137	0.138	0.146	0.154	6.0e-12	2.9e-17	2.2e-17	2.9e-18	2.4e-19
5	TCGA	Breast Invasive Carcinoma	0.0150	0.0088	8.1e-03	0.010	0.012	0.004	NA	0.006	3.1e-03	1.2e-03	4.4e-02	NA	1.6e-02
6	TCGA	Thyroid Carcinoma	0.0760	0.0290	4.2e-06	0.043	0.057	0.058	NA	0.058	5.1e-05	2.8e-06	2.4e-06	NA	2.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Chest pain or discomfort	5.2	7.6	13.4	2.3	3.2	-0.5	3.4	3.7	2.2
Diabetes (mother)	4.1	5.3	10.3	2.7	1.5	0.3	3.2	2.9	1.8
Serious illness, injury or assault of a close relative in last 2 years	3.9	4.5	10.4	-1.7	-0.3	-3.2	-2.1	-1.3	-2.8
Ever had stillbirth, spontaneous miscarriage or termination	3.9	4.2	7.3	2.5	1.8	0.6	2.5	2.7	1.4
Unable to work because of sickness or disability	3.6	4.7	8.3	1.7	2.9	1.1	2.4	2.4	2.1
Type 2 Diabetes (T2D) (2012)	2.8	3.2	6.5	2.5	2.5	0.3	1.8	1.7	0.7
Ever unenthusiastic/disinterested for a whole week	2.8	3.4	5.8	2.4	2.4	0.4	2.1	1.9	1.1
Angina	2.7	3.6	5.3	2.0	2.3	-1.6	2.1	2.2	0.3
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	5.8	2.4	1.1	0.1	2.4	2.1	1.1
Loud music exposure frequency	2.6	2.8	8.4	-0.0	1.6	2.9	0.8	0.3	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	5.6	1.9	2.4	0.9	2.1	2.1	1.5
Systolic Blood Pressure	2.5	12.7	22.6	3.4	2.3	1.6	4.8	4.1	4.2
Heart attack	2.4	3.0	5.9	2.1	1.5	-2.4	1.5	1.6	-0.8
Illnesses of siblings	2.4	3.4	6.3	-1.9	-2.5	-0.1	-2.1	-2.1	-1.2
Friendships satisfaction	2.4	2.9	6.1	-1.5	-1.2	0.1	-2.5	-2.1	-1.9
Mineral and other dietary supplements	2.4	3.2	6.0	2.0	0.5	-2.5	2.2	2.0	-0.1
Lupus	2.3	3.5	8.9	0.9	1.0	1.7	2.2	1.6	3.0
Father’s age at death	2.3	3.1	5.8	-2.4	-0.8	2.1	-1.9	-2.0	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	5.9	2.0	2.4	-1.6	1.4	1.5	-0.2
Heart attack/myocardial infarction (self-reported)	2.3	2.9	5.2	2.1	1.6	-2.3	1.5	1.6	-0.7
Ulcerative Colitis	2.2	3.1	7.9	2.8	1.9	-0.5	2.0	1.7	0.1
Hand grip strength (right)	2.2	6.0	10.5	-3.2	-2.5	-0.1	-2.9	-3.0	-1.4
Coronary Artery Disease (CAD)	2.1	2.5	8.8	1.4	0.0	-3.0	1.1	1.1	-1.4
Forced vital capacity (FVC)	2.1	8.0	13.6	-3.3	-2.2	0.2	-3.7	-3.6	-2.4
Risk taking	2.1	3.1	7.6	2.1	2.8	-0.6	1.7	1.8	0.1
Vascular/heart problems diagnosed by doctor	2.1	5.8	11.6	-2.3	-2.1	-0.6	-3.4	-2.1	-3.0
Heart disease (siblings)	2.1	2.5	7.0	1.8	2.7	0.5	1.6	1.1	0.9
Illnesses of mother	2.0	2.5	4.0	-1.5	-0.7	-1.3	-1.9	-1.7	-2.0
Standing height	2.0	19.5	32.7	-4.5	-4.5	-0.7	-5.7	-4.8	-4.5
Angina (self-reported)	2.0	2.6	3.9	1.7	1.9	-1.3	1.9	2.0	0.4
Heart disease (mother)	2.0	2.5	5.6	1.5	0.7	0.8	2.4	1.1	2.2
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	8.3	0.5	-0.4	2.9	1.1	0.4	2.2
Average weekly red wine intake	2.0	2.9	4.7	2.2	0.8	-1.8	2.1	2.1	-0.3
Commuting to job workplace: Walk	2.0	2.1	5.2	-0.8	1.9	2.3	-0.1	-0.5	1.7
Frequency of depressed mood in last 2 weeks	1.9	2.7	6.7	1.0	2.6	1.5	1.2	1.4	1.6
Trunk fat-free mass	1.9	10.8	14.7	-3.3	-3.8	-1.5	-3.8	-3.4	-3.2
Trunk predicted mass	1.9	10.8	15.0	-3.3	-3.8	-1.5	-3.9	-3.4	-3.3
Arm fat-free mass (right)	1.9	9.7	15.7	-3.2	-4.0	-1.7	-3.4	-3.1	-2.8
Emphysema/chronic bronchitis	1.9	2.1	4.0	1.7	0.7	-2.0	1.6	1.7	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	3.0	1.6	1.4	1.1	1.7	1.7	1.4
Arm predicted mass (right)	1.9	9.5	15.1	-3.1	-3.9	-2.0	-3.3	-3.0	-3.0
Medication for cholesterol	1.9	2.9	6.5	-1.2	-1.0	-0.8	-2.3	-1.5	-2.5
Worry (Nagel 2018)	1.8	3.8	7.3	2.7	2.2	0.3	2.2	2.1	1.0
Crohns Disease (2012)	1.8	2.9	7.2	2.1	0.9	-0.6	2.0	2.7	0.7
Height	1.8	34.0	59.3	-6.1	-5.3	-1.1	-7.7	-6.6	-5.9
Sitting height	1.8	13.1	21.6	-4.3	-3.9	0.1	-4.7	-3.9	-2.9
Knee pain experienced in last month	1.8	2.9	6.1	-1.0	-2.5	-1.4	-1.7	-1.0	-2.1
Whole body fat-free mass	1.8	10.1	14.8	-3.2	-3.9	-1.6	-3.7	-3.2	-3.1
Ever had bowel cancer screening	1.8	2.1	4.6	2.2	0.9	-1.6	1.2	1.4	-1.0
Whole body water mass	1.8	10.2	15.3	-3.2	-3.9	-1.6	-3.7	-3.3	-3.1
Basal metabolic rate	1.8	9.9	15.4	-3.0	-3.9	-1.8	-3.5	-3.1	-3.1
Arm fat-free mass (left)	1.8	9.4	13.5	-2.9	-3.7	-2.0	-3.4	-2.9	-3.2
Body Mass Index (BMI) (2010)	1.7	2.3	5.0	1.5	2.2	0.4	1.6	1.6	1.1
Cardiovascular Disease	1.7	5.6	9.9	2.1	2.0	1.2	3.2	2.2	3.0
Medication for hormone replacement therapy	1.7	1.9	5.1	1.0	0.5	0.2	1.8	2.2	1.3
Hip circumference	1.7	7.1	11.7	-1.6	-2.8	-3.2	-2.4	-2.1	-3.4
Medication: Ventolin 100micrograms inhaler	1.7	2.2	3.6	1.2	1.9	0.7	1.7	1.7	1.4
High blood pressure (siblings)	1.7	2.5	4.3	1.3	1.9	0.3	2.1	1.7	1.7
Hypertension (Self-reported)	1.7	4.7	10.6	1.7	1.7	1.5	2.8	1.4	3.3
Number of operations (self-reported)	1.7	2.6	4.4	1.9	0.9	-1.6	2.0	2.1	0.1
Fractured/broken bones in last 5 years	1.7	2.2	4.7	1.4	1.4	-2.2	0.6	1.7	-1.3
Arm predicted mass (left)	1.7	8.4	13.9	-2.9	-3.7	-1.6	-3.2	-2.9	-2.7
LDL Cholesterol	1.6	2.6	5.2	1.6	2.3	0.4	1.9	1.4	1.3
Ever used hormone-replacement therapy (HRT)	1.6	2.1	3.8	1.7	1.1	-0.1	1.8	1.9	1.1
Pack years adult smoking proportion	1.6	2.4	4.5	1.8	1.8	-0.6	1.6	2.1	0.2
Qualifications: CSEs or equivalent	1.6	2.2	5.2	1.1	2.3	-1.0	1.4	1.8	0.4
High blood pressure	1.6	4.4	8.7	1.8	1.6	1.2	2.9	1.5	3.0
Medication: Gliclazide	1.6	1.8	4.3	2.1	1.8	-0.9	1.0	0.9	-0.6
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.6	1.9	0.7	0.3	1.9	1.7	0.9
Supplements: Fish oil (including cod liver oil)	1.6	2.1	8.6	-1.0	0.3	2.9	-1.0	-0.8	1.2
Number of treatments/medications taken	1.5	2.7	4.8	1.4	2.1	0.2	2.2	1.1	1.9
Leg fat-free mass (left)	1.5	8.1	13.1	-2.8	-3.6	-1.6	-3.2	-2.8	-2.7
Leg predicted mass (left)	1.5	8.2	13.0	-2.8	-3.6	-1.6	-3.2	-2.8	-2.7
Hair/balding pattern: Pattern 3	1.5	2.3	5.2	2.3	2.2	-0.8	0.9	1.2	-0.7
Leg fat-free mass (right)	1.5	8.0	13.8	-3.0	-3.7	-1.2	-3.2	-2.8	-2.4
Qualifications: nursing, teaching	1.5	2.3	4.0	-1.3	-1.3	-0.8	-2.0	-1.5	-2.0
Leg predicted mass (right)	1.5	8.2	13.9	-3.0	-3.7	-1.2	-3.3	-2.9	-2.5
Ever had prostate specific antigen (PSA) test	1.5	1.8	3.8	-0.9	-1.1	-0.8	-1.7	-1.1	-1.9
Depression (Nagel 2018)	1.4	2.0	4.2	0.6	2.1	1.3	1.2	1.3	1.7
Ovarian Cancer	1.4	1.8	4.8	0.7	2.2	-1.8	-0.3	0.1	-1.5
Hand grip strength (left)	1.4	3.7	4.8	-2.1	-1.4	-1.6	-2.2	-2.0	-2.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.5	1.4	1.6	0.2	1.4	1.4	0.7
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	4.8	1.5	1.6	-2.2	1.1	1.1	-1.2
High cholesterol (Self-reported)	1.4	2.5	7.0	1.6	2.6	0.1	1.6	1.6	0.9
Pack years of smoking	1.4	2.1	3.8	1.8	1.6	-0.8	1.6	1.9	0.1
Schizophrenia (2018)	1.3	2.6	7.9	0.1	0.9	2.2	1.3	0.7	2.8
Hearing difficulty/problems with background noise	1.3	2.1	4.4	-2.1	-1.2	0.7	-1.5	-2.0	-0.1
Hair/balding pattern: Pattern 2	1.3	1.7	2.6	-1.6	-1.5	-1.2	-1.4	-0.4	-1.3
Weight	1.3	6.3	9.2	-2.0	-3.0	-2.1	-2.5	-2.3	-2.8
Medication: Cholesterol lowering	1.3	1.9	4.0	0.4	1.9	1.4	1.3	0.4	2.0
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.9	-2.0	-1.7	-0.4	-1.2	-1.4	-0.1
Medication: Blood pressure	1.3	2.2	6.3	0.8	0.1	1.0	2.0	1.1	2.5
Leg pain on walking	1.3	1.6	4.5	-0.9	-1.6	1.0	0.8	-0.1	2.1
Ever taken oral contraceptive pill	1.3	1.4	4.1	-1.2	1.3	2.0	-0.8	-0.3	0.9
Ever had hysterectomy (womb removed)	1.2	1.4	2.4	1.2	1.5	-0.1	1.4	1.5	0.5
High blood pressure (mother)	1.2	1.7	3.2	0.5	1.2	1.6	1.2	1.2	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	4.2	2.1	1.2	-0.9	1.3	1.7	-0.5
Peak expiratory flow (PEF)	1.2	2.8	5.3	-2.2	-0.6	0.2	-2.3	-2.2	-1.3
Had major operations	1.2	1.4	2.9	1.2	0.9	-1.7	0.9	1.3	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.2	-0.8	-0.2	-1.2	-1.5	-1.0	-1.8
Irritability	1.2	2.1	3.6	1.8	1.4	0.1	1.8	1.9	0.8
Age started oral contraceptive pill	1.2	1.4	4.0	-0.3	-0.5	-2.0	-0.9	-0.5	-1.8
Neuroticism (Nagel 2018)	1.1	2.7	4.0	1.9	2.0	0.0	1.9	1.9	1.1
Medication: Atenolol	1.1	1.4	2.8	1.2	0.9	-1.0	1.7	1.3	0.9
Fluid intelligence score	1.1	2.3	4.3	-1.4	-2.1	0.2	-1.9	-1.6	-1.4
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	6.8	-2.4	-1.0	0.5	-2.6	-2.5	-1.5
Birth weight	1.1	2.3	5.9	0.7	-1.6	-2.2	-0.6	0.0	-2.4
Forced vital capacity (FVC), Best measure	1.1	4.2	6.9	-2.5	-1.8	0.5	-2.6	-2.5	-1.5
Shortness of breath walking on level ground	1.1	1.3	2.7	1.0	1.6	0.1	1.6	0.6	1.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.2	-0.3	0.2	2.0	0.4	0.3	1.7
Neck or shoulder pain in last month	1.1	1.6	4.7	0.4	2.2	0.2	1.4	0.9	1.3
Medication: Atorvastatin	1.1	1.3	3.6	0.0	-0.0	1.8	0.9	0.3	1.9
Cholesterol lowering medication	1.1	1.6	2.4	1.6	1.2	0.6	1.5	1.3	1.1
Alzheimer’s Disease (in mother)	1.0	1.1	1.8	0.8	1.1	1.1	0.9	0.9	1.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.7	-0.6	-1.1	-1.6	-0.9	-0.1	-1.6
Average weekly fortified wine intake	1.0	1.1	2.7	0.9	1.0	-1.6	0.1	-0.1	-1.4
Waist circumference	1.0	3.6	9.8	-0.4	-1.4	-3.1	-1.2	-1.1	-2.7
Pulse wave reflection index	1.0	1.2	2.9	1.0	0.1	-0.8	1.7	1.5	0.7
Headache pain in last month	1.0	1.7	3.0	-1.7	-0.8	-0.9	-1.5	-1.7	-1.1
Comparative height size at age 10	1.0	5.5	10.9	-2.3	-2.4	0.4	-3.3	-2.5	-2.2
Medication: Aspirin	1.0	1.3	2.1	1.1	1.4	0.4	1.4	0.9	1.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	5.4	1.1	2.3	-1.2	0.6	0.8	-0.6
Osteoporosis (self-reported)	1.0	1.2	2.0	-0.9	-1.2	-0.6	-1.4	-0.8	-1.4
Intelligence (Savage-Jansen 2018)	0.9	2.8	4.9	-1.3	-1.5	-0.3	-2.2	-2.0	-2.0
Smoking Status	0.9	2.1	5.6	0.5	0.4	1.7	1.6	1.1	2.4
Supplements: Zinc	0.9	0.9	1.5	-0.6	-0.9	-0.5	-1.1	-1.2	-1.2
Medication: Levothyroxine sodium	0.9	1.5	3.3	-1.8	-1.6	0.8	-0.8	-1.0	0.6
Pain all over the body in last month	0.9	0.9	1.9	-0.7	-0.8	-1.4	-0.9	-0.5	-1.2
Alcohol intake versus 10 years previously	0.9	1.3	2.4	1.2	1.6	0.5	1.1	1.5	0.6
Medication: Lansoprazole	0.9	1.1	2.0	-0.2	1.4	-0.9	-1.0	-1.1	-1.2
Length of working week for main job	0.9	1.0	2.8	0.1	-1.2	-1.7	-0.1	0.3	-1.2
Wheeze or whistling in the chest in last year	0.9	1.5	2.8	1.2	1.6	-0.1	1.4	1.7	0.5
Migraine (self-reported)	0.9	1.1	2.0	-1.3	-1.4	-0.1	-1.2	-1.2	-0.5
Medication: Ibuprofen	0.9	1.1	4.3	0.4	1.0	-2.1	0.4	0.1	-0.9
Alcohol intake frequency.	0.9	2.1	3.9	-1.5	-2.0	-0.2	-1.8	-1.4	-0.9
Mood swings	0.9	1.6	4.8	0.9	2.2	0.2	1.2	1.3	0.9
Medication: Aspirin	0.9	1.1	2.5	1.1	1.6	-0.1	1.3	0.8	0.8
Guilty feelings	0.9	1.4	3.1	1.7	1.2	-0.3	0.8	1.8	-0.1
Hearing aid user	0.9	1.0	2.3	-0.2	-1.2	-0.4	-1.2	-0.9	-1.5
Medication: Blood pressure	0.9	1.6	3.9	1.6	0.6	-0.5	2.0	1.2	1.2
Ever depressed for a whole week	0.9	1.1	2.5	1.2	1.6	0.1	1.1	0.9	0.6
Neuroticism	0.8	1.9	3.1	0.7	1.7	1.4	1.1	1.2	1.8
Systolic blood pressure, automated reading	0.8	2.4	5.3	1.2	1.0	0.2	2.3	1.4	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.8	-0.3	1.1	1.3	0.9	0.8	1.7
Medication: Simvastatin	0.8	1.2	3.7	0.4	1.9	0.8	0.8	0.4	1.3
Exposure to tobacco smoke at home	0.8	0.9	2.4	-1.1	-0.4	1.5	-0.6	-0.9	0.8
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.5	-0.3	-0.2	-1.2	-1.3	-0.3	-2.1
Eye problems/disorders: None of the above	0.8	0.9	2.2	-1.1	-1.5	0.8	-1.1	-0.3	0.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.9	0.5	-1.0	-0.9	1.4	1.0	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.1	-0.0	1.4	-1.5	-0.3	-0.5	-1.0
Back pain experienced in last month	0.8	1.1	2.2	0.6	1.2	0.7	1.2	0.7	1.5
Commuting to job workplace: Public transport	0.8	1.0	2.2	-0.9	0.4	0.8	-1.5	-1.1	-1.0
Myopia	0.8	1.2	1.7	-1.1	-0.7	-0.9	-1.3	-1.3	-1.2
Supplements: Calcium	0.8	0.9	2.1	0.8	1.4	-0.3	-0.7	0.0	-1.4
Alzheimer’s Disease (in father)	0.7	0.7	1.3	-1.1	-0.7	0.4	-1.1	-1.1	-0.0
Schizophrenia (2014)	0.7	1.6	4.8	-0.2	-0.0	2.1	0.6	0.4	2.2
Triglycerides	0.7	1.1	2.1	0.9	0.8	0.6	1.5	0.9	1.3
Current tobacco smoking	0.7	1.2	2.4	1.1	0.7	0.8	1.5	1.0	1.2
Age when periods started (menarche)	0.7	1.7	2.7	-1.7	-1.5	0.0	-1.6	-1.5	-0.6
Multivitamins +/- minerals	0.7	0.9	2.8	1.0	0.7	1.7	0.5	-0.2	0.7
Chronic bronchitis/emphysema (father)	0.7	0.8	3.8	0.8	1.9	-0.4	0.6	0.3	-0.1
Falls in the last year	0.7	0.9	2.6	0.5	0.5	-1.4	-0.5	0.1	-1.6
Number of live births	0.7	0.9	1.7	-0.8	-1.3	-1.3	-0.5	-0.8	-0.7
Medication: Amlodipine	0.7	0.9	2.4	0.7	0.4	-0.0	1.6	0.3	1.5
Exposure to tobacco smoke outside home	0.7	0.9	2.2	1.5	0.7	0.0	1.1	1.1	0.4
Medication for pain relief, constipation, heartburn	0.7	1.2	4.3	-0.5	-2.1	0.5	-1.2	-0.5	-0.9
Age at last live birth	0.7	1.0	3.2	0.8	-0.6	-1.8	0.6	0.8	-0.8
Breast cancer (self-reported)	0.7	0.8	1.8	1.3	-0.2	-0.9	0.8	1.2	-0.3
Number of self-reported non-cancer illnesses	0.7	1.2	3.0	1.3	1.0	-0.0	1.7	0.4	1.3
Mother’s age at death	0.7	0.9	1.7	1.2	1.3	-0.2	0.9	1.3	0.2
Medication: Lisinopril	0.7	0.9	3.3	-0.3	-0.7	0.5	1.0	0.3	1.8
Schizophrenia vs Biploar Disorder	0.6	0.8	2.2	-0.5	0.6	1.5	0.2	0.2	1.4
Primary Biliary Cirrhosis	0.6	0.9	1.7	-0.3	-1.1	-0.9	-0.7	-0.9	-1.3
Blood White Count	0.6	4.7	7.0	-2.2	-2.6	-2.2	-2.2	-1.4	-2.3
Hypothyroidism (self reported)	0.6	1.4	4.1	-1.7	-2.0	0.1	-0.8	-0.9	0.1
Respiratory disease	0.6	1.4	3.0	1.5	0.5	-1.3	1.0	1.7	-0.5
Vitamin and mineral supplements	0.6	0.8	3.4	0.1	-0.0	-1.9	0.5	1.0	-0.4
Supplements: Glucosamine	0.6	0.8	1.6	-1.0	-0.9	0.5	-1.3	-0.9	-0.5
Trunk fat mass	0.6	2.5	4.1	-0.9	-1.7	-1.8	-1.4	-1.5	-2.0
Neuroticism score	0.6	1.2	3.3	1.0	1.8	0.4	1.0	0.9	0.9
Noisy workplace	0.6	0.7	1.6	1.1	0.7	0.0	1.3	0.8	0.5
Depression (self-reported)	0.6	0.7	2.7	0.6	1.6	1.1	0.0	0.0	0.3
Prospective memory result	0.6	0.7	1.6	0.5	0.9	-0.9	0.9	1.2	0.3
Gout (self-reported)	0.6	0.8	1.7	0.6	1.3	-0.1	1.1	1.0	0.8
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.5	-1.6	-1.2	0.9	-0.4	-0.8	1.0
Comparative body size at age 10	0.6	1.6	3.8	1.9	0.6	-1.5	0.6	1.0	-1.4
Age at first live birth	0.6	1.1	1.9	-0.5	-1.4	-1.2	-0.8	-0.9	-1.3
Pulse wave peak to peak time	0.6	0.7	2.0	-0.9	-0.6	0.3	-1.4	-0.7	-0.7
Whole body fat mass	0.6	2.4	3.5	-0.9	-1.8	-1.9	-1.3	-1.3	-1.9
Alcohol drinker status: Never	0.6	0.7	2.3	1.0	1.5	0.0	-0.2	0.3	-1.0
Commuting to job workplace: Cycle	0.6	0.8	1.5	-0.6	-1.2	0.5	-1.1	-1.0	-0.6
Ulcerative Colitis (UC)	0.5	0.9	3.3	0.7	-0.1	-0.9	-0.7	-0.5	-1.8
Major Depression (MDD)	0.5	0.6	1.2	0.8	-0.5	-0.8	1.0	1.1	0.0
Mean Putamen Volume	0.5	0.6	1.4	1.1	0.5	0.2	0.9	1.2	0.3
HDL Cholesterol	0.5	0.8	2.2	0.1	-1.0	-0.8	-0.7	-0.6	-1.5
Neuroticism (2016)	0.5	0.8	1.5	-1.2	-0.4	-0.6	-1.0	-0.9	-1.0
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.3	-0.3	-0.6	1.8	0.3	-0.3	1.5
Lung FVC	0.5	2.7	6.0	-2.0	-0.1	2.0	-1.0	-2.4	1.2
Taking other prescription medications	0.5	0.8	1.5	0.8	1.2	-0.3	1.2	0.6	0.7
Financial difficulties in last 2 years	0.5	0.7	2.3	0.2	-0.2	-1.5	-0.2	0.1	-1.2
Hair/balding pattern: Pattern 4	0.5	1.2	4.3	-0.0	0.2	2.1	0.3	-0.7	1.4
Birth weight of first child	0.5	1.0	2.3	1.5	0.6	-0.9	0.6	0.9	-1.0
Leg fat mass (right)	0.5	1.8	4.5	-0.3	-1.6	-2.1	-0.7	-0.8	-1.7
Pulse rate, automated reading	0.5	1.5	3.2	-1.2	-1.8	-0.8	-0.9	-1.5	-0.7
Overall health rating	0.5	1.2	4.0	1.0	0.1	-2.0	0.7	0.7	-0.9
Smoking status: Previous	0.5	0.7	2.8	-0.4	-0.1	0.7	0.7	0.6	1.7
Loneliness, isolation	0.5	0.6	1.7	-1.3	-0.1	0.2	-1.1	-0.9	0.0
Eye problems/disorders: Cataract	0.5	0.6	1.3	0.8	1.0	-1.1	0.6	0.4	-0.5
Osteoarthritis (self-reported)	0.5	0.6	1.7	-0.3	-1.3	-0.5	-0.6	-0.7	-0.9
Smoking status: Current	0.5	0.9	1.5	0.9	0.5	0.9	1.2	0.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.1	-0.4	-0.6	-1.0	-1.1	-1.1	-1.5
Average weekly beer plus cider intake	0.5	0.7	2.0	0.7	0.2	-0.8	1.4	0.8	0.8
Leg fat mass (left)	0.5	2.0	3.9	-0.7	-1.8	-2.0	-0.9	-1.1	-1.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.9	0.2	0.1	1.3	0.8	0.3	1.7
Crohns Disease (2017)	0.4	1.0	2.4	-0.2	-1.5	-1.6	-0.2	0.6	-0.9
Irritable Bowel Disease (IBD)	0.4	1.0	2.7	0.8	-0.4	-1.6	-0.1	0.6	-1.4
HbA1C	0.4	0.5	1.0	1.0	0.4	-0.8	0.3	0.4	-1.0
Average weekly spirits intake	0.4	0.6	1.7	0.7	-0.1	0.1	1.3	0.3	1.0
Medication: Co-codamol	0.4	0.4	1.2	-1.1	-0.8	0.4	-0.0	-0.3	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.1	1.0	0.6	0.7	1.5	0.8	1.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	1.2	-0.0	0.4	0.9	0.5	0.4
Number of incorrect matches in round	0.4	0.6	2.2	0.2	1.1	1.5	0.1	0.1	0.7
Past tobacco smoking	0.4	0.7	2.3	0.1	0.1	-1.0	-0.8	-0.6	-1.5
Had other major operations	0.4	0.5	1.1	0.6	-0.2	0.0	0.9	1.0	0.7
Diabetes (self-reported)	0.4	0.7	2.9	-0.3	0.2	1.7	-0.2	-0.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.3	-1.3	-0.6	0.3	-1.5	-1.4	-1.1
Pulse wave Arterial Stiffness index	0.4	0.4	1.3	0.8	0.3	-0.3	1.1	0.5	0.4
Arm fat mass (right)	0.4	1.7	3.6	-0.5	-1.5	-1.9	-0.8	-0.8	-1.6
Breastfed as a baby	0.4	0.5	1.3	1.1	0.9	-0.4	0.7	0.6	-0.2
Blood clot in the leg (DVT)	0.4	0.5	1.6	0.0	0.2	-0.8	-0.7	0.1	-1.3
Qualifications: College or University degree	0.4	1.4	3.0	-0.5	-0.9	1.1	-1.7	-1.2	-1.4
Medication: Allopurinol	0.4	0.5	1.1	0.2	0.9	0.1	0.9	0.5	1.1
Number of full sisters	0.4	0.5	1.4	-1.2	-0.3	-0.0	-1.0	-0.6	-0.4
Suffer from ‘nerves’	0.4	0.7	1.6	1.3	1.3	0.5	0.6	0.5	0.1
Illnesses of father: Heart disease	0.4	0.5	1.4	0.9	0.5	-1.2	0.5	0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.2	-1.1	-1.5	0.7	-0.7	-0.4	0.1
Arm fat mass (left)	0.4	1.7	3.7	-0.6	-1.5	-1.9	-0.8	-0.9	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-0.2	-0.5	-0.7	-0.6	-0.8	-1.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	-0.0	0.6	0.7	0.7	0.7	1.1
Bipolar Disorder (2018)	0.3	0.4	1.0	0.2	-1.0	-0.7	-0.4	-0.5	-0.8
Age at First Birth	0.3	0.5	1.4	-0.1	-0.4	-0.4	-1.0	-0.5	-1.2
Fasting Glucose	0.3	0.4	2.0	0.1	1.4	0.3	0.2	0.4	0.1
Rheumatoid Arthritis	0.3	0.4	1.0	0.7	-0.2	-0.3	0.9	1.0	0.5
Lung FEV1/FVC ratio	0.3	1.6	3.4	1.4	0.9	0.3	1.9	1.0	1.4
Chronotype (morning person)	0.3	0.7	1.6	1.1	0.5	-0.1	1.0	1.3	0.5
Sensitivity / hurt feelings	0.3	0.5	1.3	0.2	1.2	1.1	0.2	-0.3	0.6
Diabetes (father)	0.3	0.3	0.8	0.6	0.4	0.1	0.9	0.6	0.5
Relative age voice broke	0.3	0.4	0.9	0.8	0.3	-1.0	0.9	0.2	-0.1
Nervous feelings	0.3	0.5	1.7	0.6	1.0	1.3	-0.2	-0.1	0.1
Qualifications: None of the above	0.3	0.6	2.1	0.1	0.5	0.6	0.9	0.4	1.5
Allergy	0.3	0.6	1.6	-0.7	-0.7	1.3	-0.6	-0.6	0.7
Medication: Ramipril	0.3	0.3	1.0	0.1	0.6	0.6	0.5	0.1	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.3	-0.5	1.0	0.9	0.2	0.1	1.1
Pulse rate	0.3	0.6	1.3	-0.7	-0.7	-0.1	-0.8	-1.2	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.3	0.3	0.4	-0.3	-0.8	0.2	-1.5
Asthma	0.3	0.6	1.5	0.5	-0.0	-1.2	-0.1	0.6	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.9	-0.5	1.0	-0.8	-0.2	-0.7	-0.3
Tense / ‘highly strung’	0.3	0.5	1.3	1.1	0.7	-0.1	0.7	1.0	0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	0.3	0.1	0.9	0.6	0.5	1.0
Health satisfaction	0.3	0.3	0.8	0.1	-0.5	-0.9	-0.3	-0.6	-0.7
Asthma (self-reported)	0.3	0.6	1.0	0.8	0.2	-1.0	0.2	0.9	-0.9
Average weekly champagne plus white wine intake	0.3	0.5	2.1	0.3	1.5	0.6	-0.2	0.4	-0.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	-0.1	-0.5	1.0	0.3	-0.5	0.8
Illnesses of father: High blood pressure	0.3	0.4	1.1	0.7	-0.1	-1.1	0.7	0.5	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.5	-0.1	0.2	-0.6	-0.8	-0.1	-1.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.4	0.4	0.9	-0.3	-0.2	0.8
Reaction Time	0.2	0.4	0.7	-0.7	-0.5	0.7	-0.5	-0.8	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.6	-0.3	-1.2	-0.4	-0.6	-0.4	-0.8
BMI	0.2	1.4	2.5	-0.2	-1.5	-1.6	-0.8	-0.8	-1.6
Waist Hip Ratio (WHR)	0.2	0.9	2.6	1.0	0.2	-1.6	0.3	0.4	-1.2
Allergy or Eczema	0.2	0.4	1.1	0.3	0.1	0.6	1.0	0.1	1.0
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.6	-0.3	0.8	-0.3	-0.4	0.5
Relative age of first facial hair	0.2	0.5	1.0	0.8	0.6	-0.7	1.0	0.5	0.2
Medication: Metformin	0.2	0.3	0.6	0.6	0.1	0.8	0.7	-0.0	0.7
Severe depression (siblings)	0.2	0.2	0.5	-0.5	-0.0	-0.1	-0.7	-0.3	-0.4
Trunk fat percentage	0.2	0.6	1.8	0.0	-0.7	-1.3	-0.3	-0.5	-1.1
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.4	-0.4	-0.5	-0.7	-0.4	-0.7
Maternal smoking around birth	0.2	0.2	0.6	-0.3	-0.5	0.4	0.3	0.4	0.7
Fed-up feelings	0.2	0.3	1.2	-0.4	1.1	-0.1	0.2	0.2	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	-0.2	1.0	0.7	-0.0	0.1	0.4
Body mass index (BMI)	0.2	0.9	3.6	0.1	-1.0	-1.9	0.1	-0.1	-0.8
Mouth/teeth dental problems	0.2	0.2	0.6	0.8	0.3	-0.0	0.2	0.8	-0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	-0.9	-0.3	0.1	-0.3	-1.0	0.2
Impedance of arm (right)	0.2	0.9	3.4	0.7	1.8	1.1	-0.0	0.4	-0.1
Time employed in main current job	0.2	0.2	0.9	0.9	0.0	-0.2	0.2	0.5	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.4	1.6	-0.0	-1.3	-0.3	0.4	-0.5	0.3
Lung cancer (father)	0.2	0.2	0.6	0.3	0.4	-0.4	0.6	0.8	0.1
Impedance of arm (left)	0.2	0.7	2.6	0.6	1.6	1.0	0.1	0.4	0.2
Medication: Paracetamol	0.2	0.3	1.1	-0.6	0.6	0.1	0.5	-0.2	1.0
Body fat percentage	0.2	0.8	2.8	0.2	-0.8	-1.7	-0.1	-0.3	-1.1
Leg fat percentage (right)	0.2	0.8	3.3	0.2	-0.7	-1.8	0.1	-0.2	-0.9
Mean time to correctly identify matches	0.2	0.3	0.8	-0.5	-0.8	0.3	-0.4	-0.9	0.1
Supplements: Vitamin C	0.2	0.2	0.6	0.6	0.8	0.5	0.0	-0.3	-0.4
Illnesses of siblings: Diabetes	0.2	0.3	0.8	0.0	0.1	-0.8	-0.4	0.3	-0.9
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	-0.7	0.5	0.2	-0.3	-0.6	0.3
Diabetes diagnosed by doctor	0.2	0.4	1.5	-0.2	-0.2	1.2	-0.0	-0.5	0.6
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	-0.1	-0.7	0.9	-0.1	0.4	0.4
Miserableness	0.2	0.3	0.7	0.3	0.8	-0.8	0.4	0.6	-0.1
Medication: Paracetamol	0.2	0.3	0.5	-0.2	0.4	-0.6	0.7	0.0	0.7
Leg fat percentage (left)	0.2	0.7	2.9	-0.0	-0.8	-1.7	0.0	-0.3	-0.8
Diastolic blood pressure, automated reading	0.2	0.5	2.0	-0.7	-0.3	0.4	0.5	-0.4	1.4
Pain experienced in last month	0.2	0.4	0.9	0.9	-0.2	-0.5	-0.2	0.6	-0.9
Alcohol drinker status: Previous	0.2	0.3	1.0	-0.2	-1.0	-0.7	-0.1	-0.1	-0.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	-0.3	0.8	0.2	0.2	0.3	0.7
Bipolar Disorder (2011)	0.1	0.1	0.3	0.5	-0.4	-0.1	0.3	-0.1	0.1
Blood Eosinophil Count	0.1	0.5	2.2	0.0	-1.5	0.2	0.4	0.1	0.7
Blood Red Count	0.1	0.9	1.2	-1.0	0.2	-1.0	-1.1	-0.9	-1.1
Heel T-Score	0.1	0.6	2.6	-0.0	-0.1	1.6	-0.1	-0.3	0.9
Impedance of leg (right)	0.1	0.6	1.9	0.9	1.4	0.3	0.7	0.6	0.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.2	0.3	-0.3	-0.2	0.1	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	-0.2	-0.0	0.6	0.4	-0.3	0.8
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.5	-0.1	-0.3	-0.2	-0.2	-0.1
Impedance of leg (left)	0.1	0.5	1.7	0.6	1.3	0.7	0.6	0.5	0.3
Alcohol usually taken with meals	0.1	0.1	0.2	0.4	0.3	-0.1	0.0	0.2	-0.4
Had menopause	0.1	0.1	0.3	-0.2	-0.3	0.6	-0.2	-0.5	0.4
Arm fat percentage (right)	0.1	0.6	2.2	0.4	-0.3	-1.5	-0.1	-0.1	-1.0
Worrier / anxious feelings	0.1	0.2	0.4	0.5	0.6	0.6	0.2	0.1	0.3
Happiness	0.1	0.1	0.6	0.0	0.4	0.1	-0.2	-0.8	-0.0
Glaucoma (self-reported)	0.1	0.1	0.2	0.4	0.3	-0.4	0.4	0.0	-0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.1	-0.3	-0.1	-0.4	0.1	-0.3
Number of full brothers	0.1	0.1	0.2	0.1	-0.2	0.4	0.2	0.3	0.3
Worry too long after embarrassment	0.1	0.2	0.7	-0.0	0.1	0.9	-0.1	0.1	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.1	-0.3	0.3	0.3	0.3	0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.0	0.1	0.3	0.4	0.2	0.5
Family relationship satisfaction	0.1	0.1	0.4	-0.0	-0.2	0.6	0.3	-0.0	0.4
Arm fat percentage (left)	0.1	0.5	2.2	0.3	-0.4	-1.5	0.1	-0.1	-0.7
Wears glasses or contact lenses	0.1	0.2	0.3	0.5	0.6	0.5	0.2	0.2	0.2
Financial situation satisfaction	0.1	0.1	0.2	0.5	-0.1	-0.3	-0.1	0.0	-0.4
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.1	0.4	-0.3	-0.2	-0.4	-0.2
Ever smoked	0.1	0.3	0.4	0.1	-0.6	0.6	0.3	0.5	0.6
Impedance of whole body	0.1	0.7	2.7	0.7	1.6	0.9	0.2	0.4	-0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.3	0.8	0.3	0.9	-0.6	0.3	0.9	-0.1
Hair Pigment	0.0	0.1	0.2	0.2	-0.1	-0.3	0.3	0.4	0.1
Tanning	0.0	0.1	0.2	-0.4	0.2	0.4	-0.4	-0.1	0.3
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.2	0.2	0.1	0.1	-0.0	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	0.3	0.3	-0.1	0.1	-0.2	-0.4
Number of children fathered	0.0	0.0	0.1	-0.3	-0.2	0.2	0.0	-0.1	0.2
Medication: Omeprazole	0.0	0.0	0.2	0.1	-0.1	-0.1	0.0	-0.4	-0.1
Long-standing illness, disability or infirmity	0.0	0.0	0.2	0.2	-0.1	0.4	0.1	-0.2	0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.2	-0.0	0.3	-0.1	0.2	-0.5	-0.2

Hub : Genes

DENND5B

Models

Trait associations