Hub : Genes

DGKB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.131 0.0346 7.2e-05 0.000 0.042 0.026 0.045 0.024 2.9e-01 4.0e-06 2.4e-04 1.5e-06 3.7e-04
2 TCGA Pheochromocytoma and Paraganglioma 0.310 0.0830 1.9e-04 0.175 0.117 0.154 NA 0.166 1.8e-07 2.3e-05 1.0e-06 NA 3.7e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.6 2.5 4.3 -2.1 0.8
Bipolar Disorder or Schizophrenia 2.0 4.8 8.5 -2.9 1.1
Depressed Affect (Nagel 2018) 1.0 2.1 3.3 0.9 -1.8
Depression (Nagel 2018) 1.9 2.9 3.3 1.6 1.8
Intelligence (Savage-Jansen 2018) 1.3 4.0 4.1 -2.0 2.0
Neuroticism (Nagel 2018) 0.6 1.5 2.4 0.7 -1.6
Schizophrenia (2018) 1.2 2.4 4.3 -2.1 0.7
Schizophrenia vs Biploar Disorder 0.8 1.0 1.3 -0.9 1.1
Worry (Nagel 2018) 0.2 0.4 0.6 -0.5 0.7
Alzheimer’s Disease (in mother) 2.1 2.4 3.4 1.2 -1.8
Alzheimer’s Disease (in father) 0.2 0.2 0.4 0.1 0.6
Alzheimer’s Disease (including proxy) 1.5 2.2 3.0 1.2 -1.7
Crohns Disease (2017) 0.1 0.1 0.1 0.3 -0.4
Irritable Bowel Disease (IBD) 0.5 1.2 1.3 1.1 -1.1
Ulcerative Colitis (UC) 1.3 2.4 3.3 1.2 -1.8
Major Depression (MDD) 1.4 1.7 3.4 0.2 -1.8
Reaction Time 1.3 2.4 2.9 1.4 -1.7
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.1 -1.0 0.7
Breast Cancer 0.3 0.7 1.5 -0.2 -1.2
Ovarian Cancer 0.2 0.3 0.5 -0.7 0.1
Prostate Cancer 0.4 0.6 0.8 -0.9 0.6
Age at First Birth 1.2 1.7 3.4 -1.9 -0.1
Bipolar Disorder (2011) 0.4 0.4 0.5 -0.5 0.7
Body Mass Index (BMI) (2010) 0.2 0.3 0.4 -0.4 -0.6
Coronary Artery Disease (CAD) 0.5 0.6 1.0 -0.5 1.0
Crohns Disease (2012) 0.4 0.7 0.8 -0.9 -0.7
Mean Putamen Volume 0.3 0.4 0.7 -0.2 -0.9
Fasting Glucose 0.1 0.1 0.1 0.0 0.4
HbA1C 3.8 4.2 7.3 -1.1 -2.7
HDL Cholesterol 3.1 5.2 10.4 0.3 3.2
LDL Cholesterol 1.0 1.5 2.9 -1.7 0.5
Lupus 0.6 0.8 1.2 -1.1 -0.7
Neuroticism (2016) 2.0 2.8 5.4 0.5 -2.3
Primary Biliary Cirrhosis 0.5 0.7 1.4 0.0 1.2
Rheumatoid Arthritis 1.3 1.7 2.5 1.6 1.0
Schizophrenia (2014) 2.7 5.9 9.5 -3.1 1.5
Triglycerides 0.2 0.3 0.6 -0.8 -0.1
Type 2 Diabetes (T2D) (2012) 2.0 2.3 4.6 2.1 0.1
Ulcerative Colitis 0.0 0.0 0.0 0.1 -0.2
Blood Eosinophil Count 0.1 1.0 1.9 0.1 -1.4
Blood Platelet Count 0.0 0.1 0.1 -0.4 -0.2
Blood Red Count 0.1 0.5 1.0 1.0 -0.2
Blood White Count 0.1 0.7 1.0 1.0 -0.7
Heel T-Score 0.2 1.6 3.2 0.0 1.8
BMI 0.4 2.2 3.5 1.9 -1.0
Height 0.3 5.1 6.3 -2.5 -2.0
Waist Hip Ratio (WHR) 0.4 1.6 3.0 1.7 -0.5
Systolic Blood Pressure 0.8 4.2 8.4 -2.9 -0.1
Smoking Status 1.3 3.0 4.0 -1.4 -2.0
Allergy or Eczema 0.1 0.3 0.4 0.5 -0.6
Cardiovascular Disease 0.6 2.1 2.3 -1.5 -1.4
Hypothyroidism (self reported) 0.9 2.0 3.8 2.0 -0.4
Respiratory disease 0.7 1.5 2.5 -1.6 -0.7
Type 2 Diabetes (T2D) (2018) 1.1 2.1 3.5 -0.8 1.9
Lung FEV1/FVC ratio 5.4 27.5 54.2 -0.9 -7.4
Lung FVC 0.5 2.6 4.5 -2.1 -0.8
Neuroticism 0.4 1.1 1.5 0.8 -1.2
Chronotype (morning person) 0.2 0.5 1.0 1.0 -0.1
Hair Pigment 0.2 6.1 9.2 -3.0 -1.8
Tanning 0.1 0.9 1.1 1.0 0.9
Hand grip strength (left) 0.9 2.4 4.8 -2.2 0.3
Number of treatments/medications taken 1.3 2.4 4.8 0.1 -2.2
Average weekly spirits intake 0.8 1.0 1.7 -0.5 -1.3
Sensitivity / hurt feelings 2.9 5.0 9.4 0.8 -3.1
Frequency of depressed mood in last 2 weeks 0.5 0.8 1.1 1.1 0.6
Hearing difficulty/problems: Yes 0.8 1.2 2.0 1.4 0.5
Relative age of first facial hair 1.0 2.0 3.8 -1.9 0.5
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.9 0.1 -1.4
Ever used hormone-replacement therapy (HRT) 1.1 1.4 2.7 1.6 -0.3
Ever had hysterectomy (womb removed) 0.0 0.0 0.0 0.1 -0.2
Systolic blood pressure, automated reading 0.1 0.2 0.3 -0.5 0.1
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.0 1.0 0.1
Angina 0.1 0.1 0.2 0.2 0.4
Medication for hormone replacement therapy 0.5 0.6 0.7 -0.7 -0.8
Vitamin and mineral supplements 0.7 0.9 1.8 1.3 -0.1
Supplements: Zinc 0.5 0.6 0.6 -0.7 -0.8
Medication: Co-codamol 0.4 0.5 0.5 -0.7 0.7
Medication: Metformin 0.9 1.2 2.4 -0.2 1.6
Diabetes (father) 1.2 1.5 2.0 -1.4 -1.0
Diabetes (mother) 0.2 0.2 0.4 -0.2 0.6
Severe depression (siblings) 0.1 0.2 0.3 -0.3 0.5
Pack years adult smoking proportion 2.1 3.2 6.2 0.5 2.5
Impedance of leg (right) 0.4 1.8 3.5 -0.3 -1.9
Leg fat-free mass (left) 0.1 0.4 0.7 -0.4 0.8
Trunk fat percentage 0.9 3.7 7.3 2.7 -0.4
Hand grip strength (right) 1.1 3.0 3.3 -1.7 1.8
Townsend deprivation index at recruitment 1.7 2.4 4.4 0.7 -2.1
Current tobacco smoking 0.1 0.2 0.4 -0.1 0.6
Average weekly fortified wine intake 1.1 1.3 2.6 -1.6 -0.1
Maternal smoking around birth 3.2 4.6 7.7 2.8 1.2
Fed-up feelings 0.8 1.4 2.7 -0.4 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.4 0.2 0.6
Relative age voice broke 0.7 1.1 1.3 -1.2 -0.9
Taking other prescription medications 1.5 2.4 4.5 0.5 -2.1
Age when periods started (menarche) 0.5 1.2 2.3 -1.5 -0.4
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 2.7 -1.1 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 -0.5 -0.7
Tinnitus: Yes, but not now, but have in the past 2.6 2.7 5.5 -0.1 2.3
Qualifications: CSEs or equivalent 1.2 1.6 3.2 0.1 -1.8
Serious illness, injury or assault to yourself 0.5 0.6 0.6 -0.7 -0.8
High blood pressure 0.2 0.7 1.2 -1.1 -0.4
Hayfever, allergic rhinitis or eczema 0.5 1.1 1.8 0.6 -1.3
Multivitamins +/- minerals 1.4 1.7 3.4 -1.9 0.3
Stomach or abdominal pain in last month 0.9 1.1 1.6 -0.7 -1.3
Supplements: Glucosamine 0.2 0.3 0.3 -0.6 -0.6
Diverticular disease/diverticulitis (self-reported) 2.9 3.5 4.1 2.0 -1.7
Medication: Atenolol 0.5 0.6 1.2 0.3 1.1
Medication: Levothyroxine sodium 0.5 0.8 1.6 1.3 -0.1
Sitting height 0.1 0.9 1.4 -1.2 0.6
Chronic bronchitis/emphysema (father) 0.8 1.0 1.9 1.4 0.2
High blood pressure (mother) 0.1 0.2 0.3 -0.2 -0.6
Body mass index (BMI) 0.7 2.8 5.2 2.3 0.7
Impedance of leg (left) 0.4 1.8 3.7 0.0 -1.9
Leg predicted mass (left) 0.1 0.4 0.5 -0.5 0.7
Trunk fat mass 0.6 2.5 5.0 2.2 -0.2
Waist circumference 0.5 1.8 3.5 1.9 -0.3
Number of incorrect matches in round 0.9 1.4 2.7 1.6 -0.4
Past tobacco smoking 2.3 4.2 5.4 2.3 1.8
Alcohol usually taken with meals 0.0 0.1 0.1 -0.2 0.3
Nervous feelings 0.0 0.1 0.1 -0.1 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.3 -0.3 0.6
Hearing difficulty/problems with background noise 0.1 0.2 0.3 0.6 -0.2
Hair/balding pattern: Pattern 2 0.7 0.9 1.1 1.1 0.8
Had menopause 2.0 2.6 3.8 1.9 1.2
Had other major operations 0.5 0.6 1.2 -1.1 -0.2
Forced vital capacity (FVC) 0.9 3.4 5.4 -2.3 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.4 -0.6 -0.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.6 -0.8 -0.2
Qualifications: None of the above 1.1 2.5 2.7 1.6 -1.5
Financial difficulties in last 2 years 2.5 3.4 4.7 -2.2 1.5
Mouth/teeth dental problems 1.3 2.0 3.7 0.5 1.9
Heart attack 1.0 1.3 1.8 -0.9 -1.3
Allergy 0.9 2.0 4.1 0.0 2.0
Pain all over the body in last month 1.8 2.0 3.8 -0.3 -2.0
Diabetes (self-reported) 1.5 2.3 4.6 -0.1 2.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.6 -0.2 -0.8
Medication: Ramipril 0.3 0.4 0.6 0.8 -0.4
Medication: Simvastatin 0.2 0.2 0.5 0.7 -0.1
Fluid intelligence score 0.1 0.2 0.3 -0.5 0.4
Illnesses of siblings 0.3 0.4 0.6 0.7 -0.5
Neuroticism score 0.2 0.3 0.7 0.1 -0.8
Weight 0.2 0.9 1.8 1.3 -0.1
Impedance of arm (right) 1.4 6.7 11.8 -1.3 -3.4
Arm fat percentage (right) 0.6 2.3 3.9 2.0 -0.9
Trunk fat-free mass 0.1 0.6 1.1 -1.0 0.3
Hip circumference 0.1 0.5 0.9 1.0 -0.2
Time employed in main current job 1.1 1.2 2.2 1.5 0.5
Alcohol intake versus 10 years previously 0.1 0.1 0.1 -0.4 0.1
Father’s age at death 0.4 0.5 1.0 -1.0 0.0
Worrier / anxious feelings 0.7 1.3 2.3 0.5 -1.5
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.9 1.0 0.2
Falls in the last year 0.7 1.0 1.6 -1.3 0.6
Hair/balding pattern: Pattern 3 0.6 0.9 1.1 -0.9 -1.0
Number of live births 1.0 1.5 2.8 0.4 -1.7
Forced expiratory volume in 1-second (FEV1) 2.0 6.9 8.2 -2.4 -2.9
Pulse rate 0.3 0.5 0.8 0.9 -0.4
Happiness 0.3 0.3 0.4 -0.5 -0.6
Noisy workplace 0.0 0.0 0.0 0.2 -0.1
Qualifications: A levels/AS levels or equivalent 2.8 6.3 6.6 -2.6 2.5
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 -0.4 -0.1
Mouth/teeth dental problems: Dentures 0.4 0.6 0.9 0.9 0.7
Asthma 1.1 2.2 2.3 -1.4 -1.5
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.2 -0.5 -1.1
Medication: Cholesterol lowering 0.1 0.2 0.3 0.4 -0.5
Depression (self-reported) 0.2 0.3 0.5 -0.2 0.7
Medication: Lansoprazole 0.5 0.5 0.5 0.7 0.7
Prospective memory result 2.6 3.2 6.2 2.5 0.3
Lung cancer (father) 0.6 0.7 0.9 -0.7 0.9
Illnesses of mother 0.2 0.2 0.3 -0.3 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.5 6.8 -2.0 -2.6
Pulse wave Arterial Stiffness index 4.6 5.4 10.8 -0.2 -3.3
Impedance of arm (left) 0.5 2.2 4.2 -0.5 -2.0
Arm fat mass (right) 0.4 1.6 3.1 1.8 -0.1
Trunk predicted mass 0.1 0.6 1.1 -1.1 0.3
Standing height 0.3 2.7 3.3 -1.8 -1.4
Length of working week for main job 1.0 1.2 2.0 0.5 1.4
Exposure to tobacco smoke at home 0.5 0.6 0.8 -0.9 0.6
Breastfed as a baby 0.5 0.6 1.1 -1.1 0.2
Tense / ‘highly strung’ 0.1 0.1 0.1 -0.4 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.4 0.6 0.5
Hair/balding pattern: Pattern 4 1.8 4.3 8.1 2.9 -0.6
Birth weight of first child 1.4 2.6 5.0 -0.5 2.2
Peak expiratory flow (PEF) 1.2 2.8 4.3 -1.1 -2.1
Pulse wave reflection index 1.6 2.0 3.9 -0.1 -2.0
Ever highly irritable/argumentative for 2 days 1.7 2.0 3.2 -1.8 -1.0
Loud music exposure frequency 1.1 1.2 2.3 -1.5 -0.4
Qualifications: O levels/GCSEs or equivalent 1.2 2.0 3.6 -0.5 1.9
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 1.2 -1.1 -1.1
Blood clot in the leg (DVT) 0.0 0.0 0.0 -0.1 0.1
Medication: Paracetamol 1.6 2.7 4.0 1.2 -2.0
Headache pain in last month 0.3 0.5 0.9 -0.4 -0.9
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.1 0.0 0.4
Glaucoma (self-reported) 0.5 0.5 0.6 0.8 -0.7
Gout (self-reported) 1.1 1.5 2.4 0.8 1.6
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 2.9 1.7 0.4
Medication: Amlodipine 2.5 3.5 4.8 -2.2 1.5
Medication: Ventolin 100micrograms inhaler 1.7 2.1 4.1 -2.0 0.4
Birth weight 1.4 3.0 5.3 -2.3 -0.8
Chronic bronchitis/emphysema (mother) 1.9 2.2 2.3 1.5 1.5
High blood pressure (siblings) 0.5 0.7 1.3 0.2 1.2
Forced vital capacity (FVC), Best measure 0.7 2.6 4.4 -2.1 -0.9
Body fat percentage 0.9 3.7 7.1 2.7 -0.4
Leg fat percentage (right) 0.8 2.8 5.6 2.4 -0.2
Arm fat-free mass (right) 0.4 1.9 3.6 -0.3 1.9
Exposure to tobacco smoke outside home 0.8 1.1 2.1 0.1 -1.4
Comparative body size at age 10 0.5 1.3 2.5 -0.1 -1.6
Number of full brothers 0.5 0.7 0.7 0.8 -0.9
Worry too long after embarrassment 0.6 1.1 2.0 -0.4 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 2.5 -1.3 1.6
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 0.6 -0.0
Number of children fathered 0.4 0.5 0.5 0.7 0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.3 1.5 -0.1
Age at first live birth 2.1 3.7 6.1 -2.5 1.2
Pulse wave peak to peak time 4.4 5.2 10.4 -0.1 3.2
Health satisfaction 0.1 0.2 0.4 0.6 -0.1
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.2 -0.4
Qualifications: College or University degree 2.0 6.3 6.4 -2.5 2.5
Eye problems/disorders: None of the above 2.8 3.2 4.8 -1.3 -2.2
Mouth/teeth dental problems: Loose teeth 0.5 0.5 1.0 0.2 1.0
Emphysema/chronic bronchitis 0.1 0.1 0.3 -0.5 0.0
Medication for pain relief, constipation, heartburn 1.7 2.9 5.8 0.0 2.4
Neck or shoulder pain in last month 3.0 4.3 7.0 2.7 -1.2
Medication: Blood pressure 0.3 0.4 0.7 -0.9 -0.4
Angina (self-reported) 0.1 0.1 0.2 0.1 0.4
Migraine (self-reported) 0.1 0.1 0.1 -0.2 -0.3
Medication: Ibuprofen 1.0 1.3 2.1 -0.7 -1.4
Medication: Allopurinol 0.3 0.5 0.5 0.7 0.7
Medication: Omeprazole 0.0 0.0 0.0 0.1 0.0
Medication: Seretide 50 evohaler 3.1 3.6 4.9 -1.5 2.2
Mean time to correctly identify matches 2.3 4.3 4.4 2.1 -2.1
Heart disease (mother) 1.0 1.2 1.7 0.8 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.2 0.1 1.5
Whole body fat mass 0.5 2.2 4.4 2.1 -0.1
Leg fat mass (right) 0.5 2.1 4.1 2.0 0.2
Arm predicted mass (right) 0.3 1.4 2.9 -0.1 1.7
Pulse rate, automated reading 0.8 2.5 3.8 1.9 1.1
Alcohol intake frequency. 0.4 1.0 1.8 1.4 -0.5
Comparative height size at age 10 0.8 4.2 8.5 0.0 -2.9
Number of full sisters 0.2 0.3 0.4 0.6 0.4
Suffer from ‘nerves’ 1.6 2.5 3.0 -1.4 1.7
Overall health rating 0.6 1.3 2.3 1.5 -0.6
Chest pain or discomfort 0.2 0.3 0.6 -0.0 0.8
Had major operations 0.0 0.0 0.0 0.2 -0.1
Age at last live birth 2.7 4.0 7.1 -2.7 0.9
Family relationship satisfaction 0.3 0.4 0.8 -0.1 -0.9
Leg pain on walking 0.1 0.1 0.3 0.5 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 3.2 0.0 -1.8
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.6 0.8 -0.5
Illness, injury, bereavement, stress in last 2 years 6.1 7.4 14.4 3.8 0.6
Medication: Aspirin 2.7 3.5 4.6 -2.1 -1.6
Supplements: Vitamin C 0.9 1.0 2.0 1.4 -0.0
Knee pain experienced in last month 0.2 0.3 0.5 0.7 -0.4
Hypertension (Self-reported) 0.2 0.6 1.1 -1.1 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 2.2 1.5 -0.2
Illnesses of father: Heart disease 0.4 0.6 1.1 -1.0 -0.2
Illnesses of siblings: Diabetes 1.8 2.2 3.3 -1.8 1.1
Smoking status: Previous 2.3 3.5 3.9 -1.8 -2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 1.6 -1.3 -0.8
Whole body fat-free mass 0.1 0.6 0.6 -0.8 0.7
Leg fat-free mass (right) 0.1 0.3 0.4 -0.5 0.7
Arm fat percentage (left) 0.6 2.4 4.8 2.2 0.0
Average weekly red wine intake 0.0 0.0 0.1 0.2 -0.1
Handedness (chirality/laterality): Left-handed 0.9 1.1 2.1 -1.5 -0.2
Mood swings 1.6 2.9 4.6 1.1 -2.2
Loneliness, isolation 0.5 0.7 0.8 0.9 -0.8
Long-standing illness, disability or infirmity 0.0 0.0 0.1 -0.0 -0.2
Ever had bowel cancer screening 0.1 0.2 0.3 0.5 0.1
Diabetes diagnosed by doctor 1.1 1.7 3.5 0.1 1.9
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.3 0.6 -1.5
Friendships satisfaction 0.5 0.6 1.1 0.2 -1.0
Qualifications: nursing, teaching 1.8 2.8 3.1 -1.6 1.8
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.7 0.2
Eye problems/disorders: Cataract 0.7 0.8 1.4 0.5 1.2
Mouth/teeth dental problems: Mouth ulcers 2.2 3.6 6.9 0.4 -2.6
Medication for cholesterol 0.6 0.9 1.7 1.3 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.5 -0.6 -0.7
Back pain experienced in last month 4.6 6.7 9.9 1.8 -3.1
Mineral and other dietary supplements 0.6 0.9 1.4 0.5 1.2
Breast cancer (self-reported) 0.1 0.1 0.3 0.1 0.5
Asthma (self-reported) 1.3 2.6 3.2 -1.4 -1.8
Osteoporosis (self-reported) 0.1 0.2 0.3 -0.2 -0.6
Osteoarthritis (self-reported) 0.0 0.0 0.0 -0.2 -0.2
Medication: Aspirin 2.2 2.9 3.5 -1.9 -1.5
Medication: Gliclazide 4.3 4.8 7.9 1.3 2.8
Illnesses of father: None of the above (group 1) 1.7 2.1 3.0 1.7 1.1
Smoking status: Current 0.0 0.1 0.1 -0.3 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 2.9 5.1 -2.3 -0.9
Whole body water mass 0.1 0.6 0.6 -0.7 0.8
Leg predicted mass (right) 0.1 0.3 0.4 -0.4 0.6
Arm fat mass (left) 0.4 1.8 3.6 1.9 0.1
Number of self-reported non-cancer illnesses 1.3 2.3 4.4 0.5 -2.1
Average weekly champagne plus white wine intake 3.4 4.6 5.5 -1.9 2.3
Miserableness 0.8 1.4 2.8 0.1 -1.7
Guilty feelings 0.7 1.0 2.0 1.4 -0.1
Wears glasses or contact lenses 0.3 0.4 0.5 0.7 -0.5
Ever taken oral contraceptive pill 2.7 3.0 3.5 1.6 -1.9
Hearing aid user 0.3 0.4 0.7 0.1 0.8
Mother’s age at death 0.6 0.7 1.4 -1.2 -0.2
Financial situation satisfaction 0.1 0.2 0.3 0.1 -0.6
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.8 -0.2 -1.3
Commuting to job workplace: Public transport 1.0 1.1 1.8 -1.4 0.6
Eye problems/disorders: Glaucoma 0.3 0.3 0.7 0.1 -0.8
Medication: Blood pressure 0.1 0.2 0.4 -0.7 0.2
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.6 0.3 -1.3
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.8 -0.4 -1.4
High cholesterol (Self-reported) 0.2 0.3 0.3 0.5 0.6
Medication: Bendroflumethiazide 0.5 0.8 0.8 0.9 0.9
Medication: Paracetamol 1.2 1.9 2.1 1.5 -1.3
Medication: Lisinopril 1.6 2.1 4.2 -0.1 2.0
Medication: Atorvastatin 0.1 0.1 0.2 -0.5 0.1
Illnesses of father: High blood pressure 1.7 2.1 3.0 -1.7 -1.1
Alcohol drinker status: Never 0.7 0.8 1.5 -0.3 1.2
Ever smoked 4.1 7.2 8.1 -2.9 -2.5
Basal metabolic rate 0.0 0.1 0.2 -0.2 0.5
Leg fat percentage (left) 1.1 3.8 7.6 2.8 -0.2
Arm fat-free mass (left) 0.1 0.4 0.9 -0.0 0.9
Number of operations (self-reported) 1.1 1.6 3.2 0.2 -1.8
Average weekly beer plus cider intake 0.1 0.2 0.2 -0.5 0.4
Irritability 0.0 0.0 0.0 0.2 -0.2
Risk taking 0.6 0.9 1.6 -0.5 -1.3
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.7 0.2 -1.3
Fractured/broken bones in last 5 years 0.5 0.6 0.8 0.7 -0.9
Age started oral contraceptive pill 2.0 2.5 4.8 -2.2 -0.5
Diastolic blood pressure, automated reading 0.0 0.0 0.0 0.2 0.2
Ever depressed for a whole week 0.6 0.7 1.1 -1.0 0.6
Unable to work because of sickness or disability 0.0 0.0 0.1 -0.3 -0.1
Commuting to job workplace: Cycle 1.2 1.5 2.8 -1.7 -0.4
Myopia 0.2 0.3 0.5 0.4 -0.7
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.4 0.6 0.6
Cholesterol lowering medication 0.3 0.4 0.8 0.1 0.9
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 0.1 -0.4
Pain experienced in last month 3.0 5.0 7.1 -1.7 2.7
Supplements: Calcium 4.0 4.4 7.3 -2.7 1.2
Basal cell carcinoma (self-reported) 0.4 0.5 1.0 -1.0 -0.0
Heart attack/myocardial infarction (self-reported) 0.9 1.1 1.7 -0.8 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.0 0.0 -0.2
Heart disease (siblings) 0.1 0.1 0.1 0.1 -0.4
Alcohol drinker status: Previous 1.8 2.1 3.7 1.9 -0.6
Pack years of smoking 2.6 3.8 7.2 0.7 2.7
Impedance of whole body 0.4 2.1 4.2 0.0 -2.1
Leg fat mass (left) 0.6 2.3 4.6 2.2 0.2
Arm predicted mass (left) 0.1 0.4 0.7 0.1 0.8