TWAS hub - DGKB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.131	0.0346	7.2e-05	0.000	0.042	0.026	0.045	0.024	2.9e-01	4.0e-06	2.4e-04	1.5e-06	3.7e-04
2	TCGA	Pheochromocytoma and Paraganglioma	0.310	0.0830	1.9e-04	0.175	0.117	0.154	NA	0.166	1.8e-07	2.3e-05	1.0e-06	NA	3.7e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Illness, injury, bereavement, stress in last 2 years	6.1	7.4	14.4	3.8	0.6
Lung FEV1/FVC ratio	5.4	27.5	54.2	-0.9	-7.4
Pulse wave Arterial Stiffness index	4.6	5.4	10.8	-0.2	-3.3
Back pain experienced in last month	4.6	6.7	9.9	1.8	-3.1
Pulse wave peak to peak time	4.4	5.2	10.4	-0.1	3.2
Medication: Gliclazide	4.3	4.8	7.9	1.3	2.8
Ever smoked	4.1	7.2	8.1	-2.9	-2.5
Supplements: Calcium	4.0	4.4	7.3	-2.7	1.2
HbA1C	3.8	4.2	7.3	-1.1	-2.7
Average weekly champagne plus white wine intake	3.4	4.6	5.5	-1.9	2.3
Maternal smoking around birth	3.2	4.6	7.7	2.8	1.2
HDL Cholesterol	3.1	5.2	10.4	0.3	3.2
Medication: Seretide 50 evohaler	3.1	3.6	4.9	-1.5	2.2
Neck or shoulder pain in last month	3.0	4.3	7.0	2.7	-1.2
Pain experienced in last month	3.0	5.0	7.1	-1.7	2.7
Sensitivity / hurt feelings	2.9	5.0	9.4	0.8	-3.1
Diverticular disease/diverticulitis (self-reported)	2.9	3.5	4.1	2.0	-1.7
Qualifications: A levels/AS levels or equivalent	2.8	6.3	6.6	-2.6	2.5
Eye problems/disorders: None of the above	2.8	3.2	4.8	-1.3	-2.2
Schizophrenia (2014)	2.7	5.9	9.5	-3.1	1.5
Age at last live birth	2.7	4.0	7.1	-2.7	0.9
Medication: Aspirin	2.7	3.5	4.6	-2.1	-1.6
Ever taken oral contraceptive pill	2.7	3.0	3.5	1.6	-1.9
Tinnitus: Yes, but not now, but have in the past	2.6	2.7	5.5	-0.1	2.3
Prospective memory result	2.6	3.2	6.2	2.5	0.3
Pack years of smoking	2.6	3.8	7.2	0.7	2.7
Financial difficulties in last 2 years	2.5	3.4	4.7	-2.2	1.5
Medication: Amlodipine	2.5	3.5	4.8	-2.2	1.5
Past tobacco smoking	2.3	4.2	5.4	2.3	1.8
Mean time to correctly identify matches	2.3	4.3	4.4	2.1	-2.1
Smoking status: Previous	2.3	3.5	3.9	-1.8	-2.0
Mouth/teeth dental problems: Mouth ulcers	2.2	3.6	6.9	0.4	-2.6
Medication: Aspirin	2.2	2.9	3.5	-1.9	-1.5
Alzheimer’s Disease (in mother)	2.1	2.4	3.4	1.2	-1.8
Pack years adult smoking proportion	2.1	3.2	6.2	0.5	2.5
Age at first live birth	2.1	3.7	6.1	-2.5	1.2
Bipolar Disorder or Schizophrenia	2.0	4.8	8.5	-2.9	1.1
Neuroticism (2016)	2.0	2.8	5.4	0.5	-2.3
Type 2 Diabetes (T2D) (2012)	2.0	2.3	4.6	2.1	0.1
Had menopause	2.0	2.6	3.8	1.9	1.2
Forced expiratory volume in 1-second (FEV1)	2.0	6.9	8.2	-2.4	-2.9
Qualifications: College or University degree	2.0	6.3	6.4	-2.5	2.5
Age started oral contraceptive pill	2.0	2.5	4.8	-2.2	-0.5
Depression (Nagel 2018)	1.9	2.9	3.3	1.6	1.8
Chronic bronchitis/emphysema (mother)	1.9	2.2	2.3	1.5	1.5
Pain all over the body in last month	1.8	2.0	3.8	-0.3	-2.0
Hair/balding pattern: Pattern 4	1.8	4.3	8.1	2.9	-0.6
Illnesses of siblings: Diabetes	1.8	2.2	3.3	-1.8	1.1
Qualifications: nursing, teaching	1.8	2.8	3.1	-1.6	1.8
Alcohol drinker status: Previous	1.8	2.1	3.7	1.9	-0.6
Townsend deprivation index at recruitment	1.7	2.4	4.4	0.7	-2.1
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	2.7	-1.1	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.5	6.8	-2.0	-2.6
Ever highly irritable/argumentative for 2 days	1.7	2.0	3.2	-1.8	-1.0
Medication: Ventolin 100micrograms inhaler	1.7	2.1	4.1	-2.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	2.5	-1.3	1.6
Medication for pain relief, constipation, heartburn	1.7	2.9	5.8	0.0	2.4
Illnesses of father: None of the above (group 1)	1.7	2.1	3.0	1.7	1.1
Illnesses of father: High blood pressure	1.7	2.1	3.0	-1.7	-1.1
Bipolar Disorder (2018)	1.6	2.5	4.3	-2.1	0.8
Pulse wave reflection index	1.6	2.0	3.9	-0.1	-2.0
Medication: Paracetamol	1.6	2.7	4.0	1.2	-2.0
Suffer from ‘nerves’	1.6	2.5	3.0	-1.4	1.7
Mood swings	1.6	2.9	4.6	1.1	-2.2
Medication: Lisinopril	1.6	2.1	4.2	-0.1	2.0
Alzheimer’s Disease (including proxy)	1.5	2.2	3.0	1.2	-1.7
Taking other prescription medications	1.5	2.4	4.5	0.5	-2.1
Diabetes (self-reported)	1.5	2.3	4.6	-0.1	2.1
Major Depression (MDD)	1.4	1.7	3.4	0.2	-1.8
Multivitamins +/- minerals	1.4	1.7	3.4	-1.9	0.3
Impedance of arm (right)	1.4	6.7	11.8	-1.3	-3.4
Birth weight of first child	1.4	2.6	5.0	-0.5	2.2
Birth weight	1.4	3.0	5.3	-2.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	5.1	-2.3	-0.9
Intelligence (Savage-Jansen 2018)	1.3	4.0	4.1	-2.0	2.0
Ulcerative Colitis (UC)	1.3	2.4	3.3	1.2	-1.8
Reaction Time	1.3	2.4	2.9	1.4	-1.7
Rheumatoid Arthritis	1.3	1.7	2.5	1.6	1.0
Smoking Status	1.3	3.0	4.0	-1.4	-2.0
Number of treatments/medications taken	1.3	2.4	4.8	0.1	-2.2
Mouth/teeth dental problems	1.3	2.0	3.7	0.5	1.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.2	0.0	-1.8
Asthma (self-reported)	1.3	2.6	3.2	-1.4	-1.8
Number of self-reported non-cancer illnesses	1.3	2.3	4.4	0.5	-2.1
Schizophrenia (2018)	1.2	2.4	4.3	-2.1	0.7
Age at First Birth	1.2	1.7	3.4	-1.9	-0.1
Diabetes (father)	1.2	1.5	2.0	-1.4	-1.0
Qualifications: CSEs or equivalent	1.2	1.6	3.2	0.1	-1.8
Peak expiratory flow (PEF)	1.2	2.8	4.3	-1.1	-2.1
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	3.6	-0.5	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.3	0.6	-1.5
Medication: Paracetamol	1.2	1.9	2.1	1.5	-1.3
Commuting to job workplace: Cycle	1.2	1.5	2.8	-1.7	-0.4
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.5	-0.8	1.9
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.7	1.6	-0.3
Hand grip strength (right)	1.1	3.0	3.3	-1.7	1.8
Average weekly fortified wine intake	1.1	1.3	2.6	-1.6	-0.1
Qualifications: None of the above	1.1	2.5	2.7	1.6	-1.5
Time employed in main current job	1.1	1.2	2.2	1.5	0.5
Asthma	1.1	2.2	2.3	-1.4	-1.5
Loud music exposure frequency	1.1	1.2	2.3	-1.5	-0.4
Gout (self-reported)	1.1	1.5	2.4	0.8	1.6
Diabetes diagnosed by doctor	1.1	1.7	3.5	0.1	1.9
Leg fat percentage (left)	1.1	3.8	7.6	2.8	-0.2
Number of operations (self-reported)	1.1	1.6	3.2	0.2	-1.8
Depressed Affect (Nagel 2018)	1.0	2.1	3.3	0.9	-1.8
LDL Cholesterol	1.0	1.5	2.9	-1.7	0.5
Relative age of first facial hair	1.0	2.0	3.8	-1.9	0.5
Heart attack	1.0	1.3	1.8	-0.9	-1.3
Number of live births	1.0	1.5	2.8	0.4	-1.7
Length of working week for main job	1.0	1.2	2.0	0.5	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.3	1.5	-0.1
Medication: Ibuprofen	1.0	1.3	2.1	-0.7	-1.4
Heart disease (mother)	1.0	1.2	1.7	0.8	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.2	1.5	-0.2
Commuting to job workplace: Public transport	1.0	1.1	1.8	-1.4	0.6
Hypothyroidism (self reported)	0.9	2.0	3.8	2.0	-0.4
Hand grip strength (left)	0.9	2.4	4.8	-2.2	0.3
Medication: Metformin	0.9	1.2	2.4	-0.2	1.6
Trunk fat percentage	0.9	3.7	7.3	2.7	-0.4
Stomach or abdominal pain in last month	0.9	1.1	1.6	-0.7	-1.3
Number of incorrect matches in round	0.9	1.4	2.7	1.6	-0.4
Forced vital capacity (FVC)	0.9	3.4	5.4	-2.3	-1.1
Allergy	0.9	2.0	4.1	0.0	2.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.2	-1.1	-1.1
Body fat percentage	0.9	3.7	7.1	2.7	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	0.1	1.5
Supplements: Vitamin C	0.9	1.0	2.0	1.4	-0.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.1	-1.5	-0.2
Heart attack/myocardial infarction (self-reported)	0.9	1.1	1.7	-0.8	-1.3
Schizophrenia vs Biploar Disorder	0.8	1.0	1.3	-0.9	1.1
Systolic Blood Pressure	0.8	4.2	8.4	-2.9	-0.1
Average weekly spirits intake	0.8	1.0	1.7	-0.5	-1.3
Hearing difficulty/problems: Yes	0.8	1.2	2.0	1.4	0.5
Fed-up feelings	0.8	1.4	2.7	-0.4	-1.6
Chronic bronchitis/emphysema (father)	0.8	1.0	1.9	1.4	0.2
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.9	1.7	0.4
Leg fat percentage (right)	0.8	2.8	5.6	2.4	-0.2
Exposure to tobacco smoke outside home	0.8	1.1	2.1	0.1	-1.4
Pulse rate, automated reading	0.8	2.5	3.8	1.9	1.1
Comparative height size at age 10	0.8	4.2	8.5	0.0	-2.9
Miserableness	0.8	1.4	2.8	0.1	-1.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	-0.2	-1.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.8	-0.4	-1.4
Respiratory disease	0.7	1.5	2.5	-1.6	-0.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	0.1	-1.4
Vitamin and mineral supplements	0.7	0.9	1.8	1.3	-0.1
Relative age voice broke	0.7	1.1	1.3	-1.2	-0.9
Body mass index (BMI)	0.7	2.8	5.2	2.3	0.7
Hair/balding pattern: Pattern 2	0.7	0.9	1.1	1.1	0.8
Worrier / anxious feelings	0.7	1.3	2.3	0.5	-1.5
Falls in the last year	0.7	1.0	1.6	-1.3	0.6
Forced vital capacity (FVC), Best measure	0.7	2.6	4.4	-2.1	-0.9
Eye problems/disorders: Cataract	0.7	0.8	1.4	0.5	1.2
Guilty feelings	0.7	1.0	2.0	1.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.6	0.3	-1.3
Alcohol drinker status: Never	0.7	0.8	1.5	-0.3	1.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	0.2	-1.3
Neuroticism (Nagel 2018)	0.6	1.5	2.4	0.7	-1.6
Lupus	0.6	0.8	1.2	-1.1	-0.7
Cardiovascular Disease	0.6	2.1	2.3	-1.5	-1.4
Trunk fat mass	0.6	2.5	5.0	2.2	-0.2
Arm fat percentage (right)	0.6	2.3	3.9	2.0	-0.9
Hair/balding pattern: Pattern 3	0.6	0.9	1.1	-0.9	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.2	-0.5	-1.1
Lung cancer (father)	0.6	0.7	0.9	-0.7	0.9
Worry too long after embarrassment	0.6	1.1	2.0	-0.4	-1.4
Overall health rating	0.6	1.3	2.3	1.5	-0.6
Arm fat percentage (left)	0.6	2.4	4.8	2.2	0.0
Medication for cholesterol	0.6	0.9	1.7	1.3	0.4
Mineral and other dietary supplements	0.6	0.9	1.4	0.5	1.2
Mother’s age at death	0.6	0.7	1.4	-1.2	-0.2
Risk taking	0.6	0.9	1.6	-0.5	-1.3
Ever depressed for a whole week	0.6	0.7	1.1	-1.0	0.6
Leg fat mass (left)	0.6	2.3	4.6	2.2	0.2
Irritable Bowel Disease (IBD)	0.5	1.2	1.3	1.1	-1.1
Coronary Artery Disease (CAD)	0.5	0.6	1.0	-0.5	1.0
Primary Biliary Cirrhosis	0.5	0.7	1.4	0.0	1.2
Lung FVC	0.5	2.6	4.5	-2.1	-0.8
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.1	1.1	0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.0	1.0	0.1
Medication for hormone replacement therapy	0.5	0.6	0.7	-0.7	-0.8
Supplements: Zinc	0.5	0.6	0.6	-0.7	-0.8
Age when periods started (menarche)	0.5	1.2	2.3	-1.5	-0.4
Serious illness, injury or assault to yourself	0.5	0.6	0.6	-0.7	-0.8
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.8	0.6	-1.3
Medication: Atenolol	0.5	0.6	1.2	0.3	1.1
Medication: Levothyroxine sodium	0.5	0.8	1.6	1.3	-0.1
Waist circumference	0.5	1.8	3.5	1.9	-0.3
Had other major operations	0.5	0.6	1.2	-1.1	-0.2
Medication: Lansoprazole	0.5	0.5	0.5	0.7	0.7
Impedance of arm (left)	0.5	2.2	4.2	-0.5	-2.0
Exposure to tobacco smoke at home	0.5	0.6	0.8	-0.9	0.6
Breastfed as a baby	0.5	0.6	1.1	-1.1	0.2
Glaucoma (self-reported)	0.5	0.5	0.6	0.8	-0.7
High blood pressure (siblings)	0.5	0.7	1.3	0.2	1.2
Comparative body size at age 10	0.5	1.3	2.5	-0.1	-1.6
Number of full brothers	0.5	0.7	0.7	0.8	-0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.0	0.2	1.0
Whole body fat mass	0.5	2.2	4.4	2.1	-0.1
Leg fat mass (right)	0.5	2.1	4.1	2.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.6	-1.3	-0.8
Loneliness, isolation	0.5	0.7	0.8	0.9	-0.8
Friendships satisfaction	0.5	0.6	1.1	0.2	-1.0
Medication: Bendroflumethiazide	0.5	0.8	0.8	0.9	0.9
Fractured/broken bones in last 5 years	0.5	0.6	0.8	0.7	-0.9
Prostate Cancer	0.4	0.6	0.8	-0.9	0.6
Bipolar Disorder (2011)	0.4	0.4	0.5	-0.5	0.7
Crohns Disease (2012)	0.4	0.7	0.8	-0.9	-0.7
BMI	0.4	2.2	3.5	1.9	-1.0
Waist Hip Ratio (WHR)	0.4	1.6	3.0	1.7	-0.5
Neuroticism	0.4	1.1	1.5	0.8	-1.2
Medication: Co-codamol	0.4	0.5	0.5	-0.7	0.7
Impedance of leg (right)	0.4	1.8	3.5	-0.3	-1.9
Impedance of leg (left)	0.4	1.8	3.7	0.0	-1.9
Father’s age at death	0.4	0.5	1.0	-1.0	0.0
Mouth/teeth dental problems: Dentures	0.4	0.6	0.9	0.9	0.7
Arm fat mass (right)	0.4	1.6	3.1	1.8	-0.1
Arm fat-free mass (right)	0.4	1.9	3.6	-0.3	1.9
Number of children fathered	0.4	0.5	0.5	0.7	0.7
Alcohol intake frequency.	0.4	1.0	1.8	1.4	-0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.6	0.8	-0.5
Illnesses of father: Heart disease	0.4	0.6	1.1	-1.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.5	-0.6	-0.7
Arm fat mass (left)	0.4	1.8	3.6	1.9	0.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-1.0	-0.0
Impedance of whole body	0.4	2.1	4.2	0.0	-2.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.1	-1.0	0.7
Breast Cancer	0.3	0.7	1.5	-0.2	-1.2
Mean Putamen Volume	0.3	0.4	0.7	-0.2	-0.9
Height	0.3	5.1	6.3	-2.5	-2.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	-0.8	-0.2
Medication: Ramipril	0.3	0.4	0.6	0.8	-0.4
Illnesses of siblings	0.3	0.4	0.6	0.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.9	1.0	0.2
Pulse rate	0.3	0.5	0.8	0.9	-0.4
Happiness	0.3	0.3	0.4	-0.5	-0.6
Standing height	0.3	2.7	3.3	-1.8	-1.4
Headache pain in last month	0.3	0.5	0.9	-0.4	-0.9
Medication: Blood pressure	0.3	0.4	0.7	-0.9	-0.4
Medication: Allopurinol	0.3	0.5	0.5	0.7	0.7
Arm predicted mass (right)	0.3	1.4	2.9	-0.1	1.7
Family relationship satisfaction	0.3	0.4	0.8	-0.1	-0.9
Wears glasses or contact lenses	0.3	0.4	0.5	0.7	-0.5
Hearing aid user	0.3	0.4	0.7	0.1	0.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	0.1	-0.8
Cholesterol lowering medication	0.3	0.4	0.8	0.1	0.9
Worry (Nagel 2018)	0.2	0.4	0.6	-0.5	0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.1	0.6
Ovarian Cancer	0.2	0.3	0.5	-0.7	0.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	-0.4	-0.6
Triglycerides	0.2	0.3	0.6	-0.8	-0.1
Heel T-Score	0.2	1.6	3.2	0.0	1.8
Chronotype (morning person)	0.2	0.5	1.0	1.0	-0.1
Hair Pigment	0.2	6.1	9.2	-3.0	-1.8
Diabetes (mother)	0.2	0.2	0.4	-0.2	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	0.2	0.6
High blood pressure	0.2	0.7	1.2	-1.1	-0.4
Supplements: Glucosamine	0.2	0.3	0.3	-0.6	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	-0.2	-0.8
Medication: Simvastatin	0.2	0.2	0.5	0.7	-0.1
Neuroticism score	0.2	0.3	0.7	0.1	-0.8
Weight	0.2	0.9	1.8	1.3	-0.1
Depression (self-reported)	0.2	0.3	0.5	-0.2	0.7
Illnesses of mother	0.2	0.2	0.3	-0.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	0.6	0.5
Number of full sisters	0.2	0.3	0.4	0.6	0.4
Chest pain or discomfort	0.2	0.3	0.6	-0.0	0.8
Knee pain experienced in last month	0.2	0.3	0.5	0.7	-0.4
Hypertension (Self-reported)	0.2	0.6	1.1	-1.1	-0.1
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.7	0.2
High cholesterol (Self-reported)	0.2	0.3	0.3	0.5	0.6
Myopia	0.2	0.3	0.5	0.4	-0.7
Crohns Disease (2017)	0.1	0.1	0.1	0.3	-0.4
Fasting Glucose	0.1	0.1	0.1	0.0	0.4
Blood Eosinophil Count	0.1	1.0	1.9	0.1	-1.4
Blood Red Count	0.1	0.5	1.0	1.0	-0.2
Blood White Count	0.1	0.7	1.0	1.0	-0.7
Allergy or Eczema	0.1	0.3	0.4	0.5	-0.6
Tanning	0.1	0.9	1.1	1.0	0.9
Systolic blood pressure, automated reading	0.1	0.2	0.3	-0.5	0.1
Angina	0.1	0.1	0.2	0.2	0.4
Severe depression (siblings)	0.1	0.2	0.3	-0.3	0.5
Leg fat-free mass (left)	0.1	0.4	0.7	-0.4	0.8
Current tobacco smoking	0.1	0.2	0.4	-0.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	-0.5	-0.7
Sitting height	0.1	0.9	1.4	-1.2	0.6
High blood pressure (mother)	0.1	0.2	0.3	-0.2	-0.6
Leg predicted mass (left)	0.1	0.4	0.5	-0.5	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	-0.3	0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.6	-0.3
Fluid intelligence score	0.1	0.2	0.3	-0.5	0.4
Trunk fat-free mass	0.1	0.6	1.1	-1.0	0.3
Hip circumference	0.1	0.5	0.9	1.0	-0.2
Alcohol intake versus 10 years previously	0.1	0.1	0.1	-0.4	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.4	-0.1
Medication: Cholesterol lowering	0.1	0.2	0.3	0.4	-0.5
Trunk predicted mass	0.1	0.6	1.1	-1.1	0.3
Tense / ‘highly strung’	0.1	0.1	0.1	-0.4	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.6	-0.0
Health satisfaction	0.1	0.2	0.4	0.6	-0.1
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.2	-0.4
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.5	0.0
Angina (self-reported)	0.1	0.1	0.2	0.1	0.4
Migraine (self-reported)	0.1	0.1	0.1	-0.2	-0.3
Leg pain on walking	0.1	0.1	0.3	0.5	0.1
Whole body fat-free mass	0.1	0.6	0.6	-0.8	0.7
Leg fat-free mass (right)	0.1	0.3	0.4	-0.5	0.7
Ever had bowel cancer screening	0.1	0.2	0.3	0.5	0.1
Breast cancer (self-reported)	0.1	0.1	0.3	0.1	0.5
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.2	-0.6
Whole body water mass	0.1	0.6	0.6	-0.7	0.8
Leg predicted mass (right)	0.1	0.3	0.4	-0.4	0.6
Financial situation satisfaction	0.1	0.2	0.3	0.1	-0.6
Medication: Blood pressure	0.1	0.2	0.4	-0.7	0.2
Medication: Atorvastatin	0.1	0.1	0.2	-0.5	0.1
Arm fat-free mass (left)	0.1	0.4	0.9	-0.0	0.9
Average weekly beer plus cider intake	0.1	0.2	0.2	-0.5	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.4	0.6	0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.1	-0.4
Heart disease (siblings)	0.1	0.1	0.1	0.1	-0.4
Arm predicted mass (left)	0.1	0.4	0.7	0.1	0.8
Ulcerative Colitis	0.0	0.0	0.0	0.1	-0.2
Blood Platelet Count	0.0	0.1	0.1	-0.4	-0.2
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	0.1	-0.2
Alcohol usually taken with meals	0.0	0.1	0.1	-0.2	0.3
Nervous feelings	0.0	0.1	0.1	-0.1	0.3
Noisy workplace	0.0	0.0	0.0	0.2	-0.1
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.1	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	0.0	0.4
Medication: Omeprazole	0.0	0.0	0.0	0.1	0.0
Had major operations	0.0	0.0	0.0	0.2	-0.1
Average weekly red wine intake	0.0	0.0	0.1	0.2	-0.1
Long-standing illness, disability or infirmity	0.0	0.0	0.1	-0.0	-0.2
Osteoarthritis (self-reported)	0.0	0.0	0.0	-0.2	-0.2
Smoking status: Current	0.0	0.1	0.1	-0.3	0.2
Basal metabolic rate	0.0	0.1	0.2	-0.2	0.5
Irritability	0.0	0.0	0.0	0.2	-0.2
Diastolic blood pressure, automated reading	0.0	0.0	0.0	0.2	0.2
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	0.0	-0.2

Hub : Genes

DGKB

Models

Trait associations