TWAS hub - DIO2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.406	0.107	0.00029	-0.001	NA	0.038	NA	0.000	3.3e-01	NA	0.02900	NA	3.2e-01
2	GTEx	Skin Sun Exposed Lower leg	0.080	0.028	0.00046	0.070	NA	0.044	NA	0.062	2.0e-06	NA	0.00014	NA	7.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Ever depressed for a whole week	5.3	6.6	13.1	-0.3	-3.6
Impedance of whole body	5.1	25.9	43.8	-2.8	-6.6
Impedance of arm (right)	4.7	22.1	41.6	-1.6	-6.5
Loud music exposure frequency	4.4	4.9	6.0	-2.5	-1.9
Impedance of leg (right)	4.2	20.5	32.4	-2.9	-5.7
Impedance of arm (left)	4.2	19.5	36.4	-1.6	-6.0
Hypothyroidism/myxoedema (self-reported)	4.2	8.2	13.4	3.7	-1.7
Medication: Levothyroxine sodium	4.0	6.7	11.3	3.4	-1.5
Ever unenthusiastic/disinterested for a whole week	4.0	4.9	9.6	-0.5	-3.1
Reason for reducing amount of alcohol drunk: Health precaution	3.9	4.5	4.8	-2.1	-2.2
Impedance of leg (left)	3.8	18.5	27.7	-3.0	-5.3
Mouth/teeth dental problems: Loose teeth	3.4	4.0	8.0	-2.8	-0.0
Pulse wave Arterial Stiffness index	3.3	3.8	4.4	-2.1	-1.8
Prostate Cancer	3.2	4.5	7.8	-2.8	1.1
Hypothyroidism (self reported)	3.2	7.2	11.0	3.3	-1.9
Pulse wave peak to peak time	3.1	3.6	4.7	2.2	1.6
Heart attack/myocardial infarction (self-reported)	2.8	3.6	4.6	-1.6	2.1
Had major operations	2.7	3.2	4.5	-2.1	1.4
Waist Hip Ratio (WHR)	2.5	11.3	16.4	-2.5	-4.0
Heart attack	2.5	3.3	4.3	-1.5	2.1
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	4.6	-1.7	-2.1
Back pain experienced in last month	2.4	3.5	4.4	-2.1	-1.6
Asthma (self-reported)	2.4	4.8	6.2	-2.5	-1.8
Long-standing illness, disability or infirmity	2.3	3.5	3.6	1.9	-1.8
Systolic Blood Pressure	2.2	10.8	13.9	-2.8	-3.7
Asthma	2.2	4.4	5.5	-2.4	-1.8
Medication: Omeprazole	2.2	2.6	3.5	-1.9	-1.3
Whole body fat-free mass	2.2	12.3	13.8	3.7	3.3
Leg fat-free mass (right)	2.2	11.9	13.6	3.7	3.2
Breast cancer (self-reported)	2.2	2.6	4.0	-1.1	2.0
Leg predicted mass (right)	2.2	11.8	13.8	3.7	3.1
Bipolar Disorder (2018)	2.1	3.3	6.4	2.5	-0.4
Leg fat-free mass (left)	2.1	11.1	13.8	3.7	2.9
Leg predicted mass (left)	2.1	11.1	13.9	3.7	2.9
Handedness (chirality/laterality): Left-handed	2.1	2.5	4.1	0.9	2.0
Trunk fat-free mass	2.0	11.6	12.2	3.5	3.3
Trunk predicted mass	2.0	11.5	11.9	3.5	3.3
Whole body water mass	2.0	11.7	12.5	3.5	3.3
Basal metabolic rate	2.0	11.0	12.3	3.5	3.1
Neuroticism (2016)	1.9	2.7	4.0	-2.0	1.2
Chronotype (morning person)	1.9	4.4	8.8	0.3	3.0
Allergy	1.9	4.3	6.8	2.6	1.3
Qualifications: A levels/AS levels or equivalent	1.9	4.2	6.3	1.5	-2.5
Arm fat-free mass (right)	1.9	9.8	11.6	2.8	3.4
Comparative body size at age 10	1.9	5.2	7.2	1.8	2.7
Arm predicted mass (right)	1.9	9.7	12.6	2.6	3.5
Hair/balding pattern: Pattern 2	1.8	2.3	3.6	-1.9	-1.0
Illnesses of siblings	1.8	2.5	4.2	-2.1	-0.9
Hip circumference	1.8	7.6	9.1	2.4	3.0
Fractured/broken bones in last 5 years	1.8	2.3	3.9	-2.0	-0.8
Average weekly fortified wine intake	1.7	2.0	4.0	-0.1	-2.0
Multivitamins +/- minerals	1.7	2.1	2.2	1.4	-1.5
Prospective memory result	1.7	2.1	3.5	-1.9	0.8
Heart disease (mother)	1.7	2.1	3.1	-1.0	-1.8
Arm fat-free mass (left)	1.7	8.7	10.2	2.7	3.2
Heart disease (siblings)	1.7	2.1	4.0	2.0	0.3
Arm predicted mass (left)	1.7	8.8	11.0	2.6	3.3
Medication: Lansoprazole	1.6	1.8	2.9	-1.7	0.8
Bipolar Disorder or Schizophrenia	1.5	3.7	6.9	2.6	-0.7
Bipolar Disorder (2011)	1.5	1.5	2.9	1.7	-0.1
Diabetes (mother)	1.5	1.9	2.6	-1.1	-1.6
Fed-up feelings	1.5	2.6	5.2	-2.3	0.2
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	2.3	1.1	-1.5
Mouth/teeth dental problems	1.5	2.4	3.3	1.8	1.2
Father’s age at death	1.5	2.0	3.9	2.0	-0.4
Emphysema/chronic bronchitis	1.5	1.7	3.1	-1.8	0.6
Pulse rate, automated reading	1.5	4.8	5.1	-2.1	-2.2
Medication for cholesterol	1.5	2.3	2.9	1.3	-1.7
Lung FVC	1.4	6.9	12.1	1.3	3.5
Medication: Co-codamol	1.4	1.6	1.7	-1.3	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.4	2.9	0.2	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.1	0.4	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	4.7	1.1	2.2
Unable to work because of sickness or disability	1.4	1.8	2.0	-1.3	-1.4
Reaction Time	1.3	2.4	3.2	-1.8	1.3
HbA1C	1.3	1.5	2.7	-1.6	-0.5
Systolic blood pressure, automated reading	1.3	3.7	5.3	-2.3	-1.5
Supplements: Zinc	1.3	1.4	2.4	0.7	-1.5
Qualifications: CSEs or equivalent	1.3	1.7	2.2	1.0	1.5
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	1.7	1.2	-1.3
Body mass index (BMI)	1.3	5.5	7.8	1.8	2.8
Number of live births	1.3	1.8	3.6	-1.9	-0.1
Medication: Seretide 50 evohaler	1.3	1.5	1.7	-1.1	-1.3
Mean time to correctly identify matches	1.3	2.4	3.3	-1.8	1.3
Number of operations (self-reported)	1.3	2.0	3.9	-2.0	0.4
Depressed Affect (Nagel 2018)	1.2	2.5	2.7	-1.6	1.5
Hand grip strength (left)	1.2	3.1	5.5	0.8	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	2.2	-1.5	1.0
Weight	1.2	5.7	7.4	2.7	2.0
Number of full brothers	1.2	1.6	3.1	0.1	1.8
Ever had bowel cancer screening	1.2	1.4	2.5	-1.6	-0.6
Medication: Blood pressure	1.2	2.3	2.7	-1.4	1.6
Diastolic blood pressure, automated reading	1.2	3.6	4.7	-1.6	-2.2
Alzheimer’s Disease (in father)	1.1	1.2	2.3	1.5	-0.3
Medication: Metformin	1.1	1.6	1.6	1.2	-1.3
Hand grip strength (right)	1.1	3.1	4.9	1.1	2.2
Serious illness, injury or assault to yourself	1.1	1.3	1.7	-1.3	0.9
Had menopause	1.1	1.3	2.4	-1.6	-0.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.9	0.2	-1.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.2	-1.5	0.7
Qualifications: College or University degree	1.1	3.4	4.0	2.0	-1.7
Migraine (self-reported)	1.1	1.4	2.6	-0.4	-1.6
Smoking status: Current	1.1	1.7	3.3	-1.8	-0.3
Ever taken oral contraceptive pill	1.1	1.2	1.9	0.7	-1.4
Average weekly beer plus cider intake	1.1	1.7	2.1	-1.4	-1.1
Neuroticism (Nagel 2018)	1.0	2.2	2.4	-1.5	1.5
Alzheimer’s Disease (including proxy)	1.0	1.4	2.6	1.6	-0.5
Ulcerative Colitis (UC)	1.0	1.8	3.2	-0.6	-1.8
Body Mass Index (BMI) (2010)	1.0	1.4	1.9	0.9	1.4
Ulcerative Colitis	1.0	1.5	3.0	0.1	-1.7
Sensitivity / hurt feelings	1.0	1.8	2.3	-1.5	1.1
Relative age of first facial hair	1.0	2.0	3.4	-0.8	-1.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	2.4	1.5	-0.4
Alcohol usually taken with meals	1.0	1.5	2.8	-0.5	1.7
Had other major operations	1.0	1.2	1.6	-0.9	-1.3
Diabetes (self-reported)	1.0	1.5	1.9	1.0	-1.4
Falls in the last year	1.0	1.3	2.0	1.4	-0.8
Birth weight of first child	1.0	1.9	2.7	1.6	-1.1
Pulse wave reflection index	1.0	1.3	2.4	-0.4	-1.5
Headache pain in last month	1.0	1.6	2.5	-0.9	-1.6
Medication: Amlodipine	1.0	1.4	2.7	-1.6	-0.4
Loneliness, isolation	1.0	1.3	2.3	-0.6	1.5
Arm fat mass (left)	1.0	4.2	6.3	2.5	1.5
Alcohol drinker status: Never	1.0	1.2	2.0	1.4	-0.6
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.4	1.2	0.9
Supplements: Calcium	1.0	1.1	1.7	-1.3	-0.7
Basal cell carcinoma (self-reported)	1.0	1.2	2.3	0.4	-1.5
Leg fat mass (left)	1.0	4.0	4.5	2.1	1.9
Alzheimer’s Disease (in mother)	0.9	1.1	1.8	1.3	-0.6
Hearing difficulty/problems: Yes	0.9	1.4	1.9	1.4	1.0
Current tobacco smoking	0.9	1.5	2.7	-1.7	-0.5
Relative age voice broke	0.9	1.4	2.7	-1.6	-0.4
Stomach or abdominal pain in last month	0.9	1.1	2.1	0.1	-1.5
Supplements: Glucosamine	0.9	1.1	1.2	1.1	1.0
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	4.0	2.0	1.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	2.4	1.5	-0.8
Worry too long after embarrassment	0.9	1.5	2.1	1.0	1.4
Number of children fathered	0.9	1.0	1.8	1.3	0.5
Age at first live birth	0.9	1.6	1.7	1.3	-1.3
Leg fat mass (right)	0.9	3.4	4.6	2.1	1.5
Illnesses of father: None of the above (group 1)	0.9	1.1	2.0	-0.6	1.4
Irritable Bowel Disease (IBD)	0.8	1.9	3.6	-0.3	-1.9
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.7	0.4	-1.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	-1.4	0.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.7	-1.3	-0.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	2.4	-1.6	-1.0
Depression (self-reported)	0.8	0.9	1.2	0.8	1.1
Arm fat mass (right)	0.8	3.4	5.1	2.2	1.3
Health satisfaction	0.8	1.1	1.9	0.4	-1.4
Eye problems/disorders: None of the above	0.8	0.9	1.8	1.3	-0.2
Breast Cancer	0.7	1.7	2.7	-1.6	0.8
Age at First Birth	0.7	1.0	1.6	1.3	0.5
Rheumatoid Arthritis	0.7	1.0	1.7	0.5	1.3
Schizophrenia (2014)	0.7	1.4	2.6	1.6	-0.5
Respiratory disease	0.7	1.5	2.7	-1.6	-0.6
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	-1.2	-0.0
Medication for hormone replacement therapy	0.7	0.8	1.2	-1.1	0.5
Qualifications: None of the above	0.7	1.6	1.8	-1.2	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	2.6	1.6	1.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.1	-0.7	-1.1
Gout (self-reported)	0.7	1.0	1.6	0.5	-1.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.7	-0.0	-1.3
Medication: Aspirin	0.7	0.9	1.7	-1.3	-0.1
Mother’s age at death	0.7	0.9	1.0	-1.0	0.9
Medication: Bendroflumethiazide	0.7	1.1	1.9	-0.5	-1.4
Age started oral contraceptive pill	0.7	0.9	1.4	0.7	1.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.2	-1.1	-0.8
Major Depression (MDD)	0.6	0.7	1.1	0.6	-1.0
Verbal and Numeric Reasoning (VNR)	0.6	1.3	2.3	-1.5	-0.6
BMI	0.6	3.6	5.5	1.3	2.4
Lung FEV1/FVC ratio	0.6	2.8	5.2	2.3	0.6
Age when periods started (menarche)	0.6	1.4	2.0	-0.9	-1.4
Pulse rate	0.6	1.0	1.4	-0.8	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.1	0.5	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.6	-0.1	-1.3
Medication: Cholesterol lowering	0.6	1.0	1.7	-1.3	0.5
Illnesses of mother	0.6	0.8	1.2	1.1	0.6
Exposure to tobacco smoke at home	0.6	0.7	1.0	1.0	-0.6
Birth weight	0.6	1.3	1.6	1.3	-1.0
Shortness of breath walking on level ground	0.6	0.7	1.4	-1.2	-0.1
Neck or shoulder pain in last month	0.6	0.8	1.6	-0.0	-1.3
Whole body fat mass	0.6	2.6	4.7	2.2	0.8
Age at last live birth	0.6	0.9	1.7	-0.3	-1.3
Family relationship satisfaction	0.6	0.7	1.2	1.1	0.4
Leg pain on walking	0.6	0.8	0.9	-0.8	1.0
Medication: Aspirin	0.6	0.8	1.4	-1.2	0.3
Supplements: Vitamin C	0.6	0.7	1.4	0.2	-1.2
Diabetes diagnosed by doctor	0.6	1.0	1.5	0.8	-1.2
Wears glasses or contact lenses	0.6	0.7	1.4	-0.2	-1.2
Commuting to job workplace: Cycle	0.6	0.7	1.3	0.1	1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	-0.1	1.1
Smoking Status	0.5	1.2	2.4	-1.6	-0.2
Allergy or Eczema	0.5	1.4	1.6	-1.2	-1.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	-0.2	1.2
Trunk fat mass	0.5	2.3	4.4	2.1	0.4
Pain all over the body in last month	0.5	0.6	0.6	0.8	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	0.9	-0.8	-0.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	-0.3	-1.1
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.1	1.0	0.1
High blood pressure (siblings)	0.5	0.7	1.3	1.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	-1.1	-0.3
Medication: Allopurinol	0.5	0.7	1.1	1.1	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	-1.0	0.4
Hearing aid user	0.5	0.5	0.7	0.6	-0.8
Financial situation satisfaction	0.5	0.6	0.7	0.8	-0.8
Irritability	0.5	0.9	1.8	0.0	-1.3
Intelligence (Savage-Jansen 2018)	0.4	1.4	1.7	1.3	-1.0
Schizophrenia (2018)	0.4	0.9	1.5	1.2	-0.6
Coronary Artery Disease (CAD)	0.4	0.5	0.7	-0.9	0.5
Blood White Count	0.4	2.8	5.6	0.0	-2.4
Cardiovascular Disease	0.4	1.3	2.6	-1.6	-0.1
Vitamin and mineral supplements	0.4	0.5	0.7	-0.6	0.8
Diabetes (father)	0.4	0.5	0.8	0.9	-0.5
Sitting height	0.4	2.7	5.1	2.3	-0.6
Number of incorrect matches in round	0.4	0.6	0.9	-0.6	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.3	-1.2	-0.0
Forced vital capacity (FVC)	0.4	1.7	2.1	1.4	1.2
Medication: Ramipril	0.4	0.5	0.8	0.9	-0.5
Neuroticism score	0.4	0.8	1.1	-1.1	0.6
Arm fat percentage (right)	0.4	1.6	3.2	1.8	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.1	-1.0	-0.3
Lung cancer (father)	0.4	0.5	0.9	0.4	0.9
Standing height	0.4	4.0	5.9	2.4	-1.4
Tense / ‘highly strung’	0.4	0.7	0.8	-0.9	0.7
Glaucoma (self-reported)	0.4	0.5	0.6	0.8	0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	1.2	1.1	0.3
Alcohol intake frequency.	0.4	0.9	1.8	1.3	-0.0
Number of full sisters	0.4	0.5	0.7	0.6	-0.8
Illnesses of father: Heart disease	0.4	0.5	1.0	1.0	0.0
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.2	1.0
Arm fat percentage (left)	0.4	1.8	3.6	1.9	0.1
Eye problems/disorders: Cataract	0.4	0.4	0.6	-0.8	0.4
Medication: Gliclazide	0.4	0.4	0.6	0.8	-0.5
Guilty feelings	0.4	0.6	1.1	1.0	0.3
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.5	-0.7	-0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	1.0	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	-1.0	0.2
Medication: Lisinopril	0.4	0.5	1.0	0.1	1.0
Leg fat percentage (left)	0.4	1.3	1.8	1.4	0.9
Alcohol drinker status: Previous	0.4	0.5	0.5	0.7	0.7
Pack years of smoking	0.4	0.6	0.8	0.6	0.9
Depression (Nagel 2018)	0.3	0.4	0.8	-0.1	0.9
Worry (Nagel 2018)	0.3	0.7	1.4	-1.2	-0.0
Crohns Disease (2017)	0.3	0.7	1.4	0.2	-1.2
Ovarian Cancer	0.3	0.5	0.7	-0.5	0.8
Crohns Disease (2012)	0.3	0.5	0.9	1.0	-0.4
Fasting Glucose	0.3	0.4	0.6	0.8	0.3
Triglycerides	0.3	0.5	0.9	-0.3	0.9
Blood Platelet Count	0.3	3.3	5.9	0.8	-2.4
Height	0.3	5.3	9.9	3.1	-0.8
Neuroticism	0.3	0.8	1.3	-1.2	0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.4	-0.5	0.6
High blood pressure (mother)	0.3	0.5	0.7	-0.5	0.8
Waist circumference	0.3	1.2	1.3	1.1	1.0
Happiness	0.3	0.4	0.8	-0.0	0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	0.6	-0.8	0.7
Length of working week for main job	0.3	0.3	0.6	0.1	0.8
Peak expiratory flow (PEF)	0.3	0.7	0.7	0.9	0.8
Blood clot in the leg (DVT)	0.3	0.3	0.6	-0.1	0.8
Forced vital capacity (FVC), Best measure	0.3	1.0	1.7	0.5	1.3
Leg fat percentage (right)	0.3	1.1	1.9	1.4	0.5
Wheeze or whistling in the chest in last year	0.3	0.6	1.1	-1.0	-0.4
Medication: Blood pressure	0.3	0.5	0.6	0.8	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	-0.1	-0.9
Suffer from ‘nerves’	0.3	0.5	0.7	-0.8	-0.6
Chest pain or discomfort	0.3	0.4	0.4	-0.6	-0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.6	0.8	0.3
Hypertension (Self-reported)	0.3	0.8	1.5	-1.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	0.9	1.0	-0.5
Qualifications: nursing, teaching	0.3	0.5	1.0	0.2	-1.0
Commuting to job workplace: Walk	0.3	0.3	0.7	-0.1	-0.8
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.1	0.9
Medication: Paracetamol	0.3	0.4	0.7	-0.8	-0.4
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	-0.3	0.7
HDL Cholesterol	0.2	0.4	0.7	-0.8	-0.1
Lupus	0.2	0.3	0.6	0.2	-0.8
Number of treatments/medications taken	0.2	0.4	0.6	-0.8	-0.5
Average weekly spirits intake	0.2	0.3	0.5	0.3	-0.7
Severe depression (siblings)	0.2	0.3	0.4	-0.4	0.6
Pack years adult smoking proportion	0.2	0.3	0.5	0.2	0.7
Trunk fat percentage	0.2	0.8	1.1	1.0	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	0.2	0.9
Hearing difficulty/problems with background noise	0.2	0.3	0.5	-0.7	0.4
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.7	0.4
Fluid intelligence score	0.2	0.4	0.7	-0.1	0.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	1.0	0.3
Medication: Paracetamol	0.2	0.3	0.5	-0.5	-0.7
Body fat percentage	0.2	0.8	1.4	1.2	-0.4
Exposure to tobacco smoke outside home	0.2	0.3	0.4	0.6	0.5
Angina (self-reported)	0.2	0.3	0.4	-0.4	-0.6
Comparative height size at age 10	0.2	1.2	1.7	1.3	0.9
Overall health rating	0.2	0.4	0.6	-0.5	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	0.7	0.2
Knee pain experienced in last month	0.2	0.4	0.6	0.3	0.8
Mood swings	0.2	0.4	0.7	-0.8	0.3
Mineral and other dietary supplements	0.2	0.3	0.6	-0.7	-0.2
High cholesterol (Self-reported)	0.2	0.3	0.6	0.8	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.6	0.8	-0.5
Cholesterol lowering medication	0.2	0.4	0.6	0.8	-0.4
Pain experienced in last month	0.2	0.4	0.5	-0.7	0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	-0.6	0.4
Blood Eosinophil Count	0.1	0.8	1.3	1.1	0.6
Blood Red Count	0.1	0.7	1.3	-0.4	-1.2
Angina	0.1	0.2	0.4	-0.1	-0.6
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.6	0.0
Maternal smoking around birth	0.1	0.2	0.3	-0.2	0.6
High blood pressure	0.1	0.4	0.7	-0.9	0.0
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	-0.2	0.5
Past tobacco smoking	0.1	0.2	0.3	-0.2	0.5
Nervous feelings	0.1	0.2	0.5	-0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.3	0.5	0.2
Time employed in main current job	0.1	0.2	0.3	0.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.1	0.4	0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.6	0.3
Breastfed as a baby	0.1	0.2	0.3	0.3	-0.5
Medication: Ibuprofen	0.1	0.1	0.1	-0.3	-0.4
Smoking status: Previous	0.1	0.2	0.3	-0.1	-0.5
Average weekly red wine intake	0.1	0.1	0.2	0.5	0.0
Friendships satisfaction	0.1	0.1	0.2	0.0	0.5
Osteoporosis (self-reported)	0.1	0.1	0.2	0.3	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	-0.3	-0.6
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.6	0.2
Miserableness	0.1	0.1	0.2	-0.4	-0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.4	-0.1
Ever smoked	0.1	0.1	0.1	-0.3	-0.4
Risk taking	0.1	0.1	0.2	0.4	0.1
Myopia	0.1	0.2	0.2	0.3	-0.5
Mean Putamen Volume	0.0	0.0	0.0	0.1	-0.1
LDL Cholesterol	0.0	0.0	0.0	0.1	0.2
Primary Biliary Cirrhosis	0.0	0.0	0.1	0.1	-0.3
Heel T-Score	0.0	0.2	0.3	-0.2	0.6
Hair Pigment	0.0	1.3	1.8	-1.4	0.9
Tanning	0.0	0.0	0.0	0.0	0.2
Taking other prescription medications	0.0	0.0	0.0	-0.0	-0.2
Medication: Atenolol	0.0	0.1	0.1	-0.3	-0.2
Medication: Simvastatin	0.0	0.0	0.1	0.2	0.0
Worrier / anxious feelings	0.0	0.1	0.1	0.2	-0.4
Noisy workplace	0.0	0.0	0.0	-0.0	0.0
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.3	0.1
Commuting to job workplace: Public transport	0.0	0.0	0.1	0.2	0.0
Medication: Atorvastatin	0.0	0.0	0.0	-0.2	0.1
Illnesses of father: High blood pressure	0.0	0.0	0.0	0.1	0.2

Hub : Genes

DIO2

Models

Trait associations