Hub : Genes

DKK3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0890	0.0350	5.0e-03	0.024	0.003	0.030	0.010	0.034	6.1e-04	1.3e-01	1.2e-04	2.0e-02	4.3e-05
2	GTEx	Artery Aorta	0.3980	0.1040	6.2e-04	0.226	NA	0.161	NA	0.201	1.1e-12	NA	3.5e-09	NA	2.8e-11
3	GTEx	Artery Tibial	0.3949	0.0668	9.5e-08	0.272	NA	0.269	NA	0.276	1.9e-21	NA	3.4e-21	NA	8.3e-22
4	GTEx	Brain Caudate basal ganglia	0.3860	0.1290	3.2e-03	-0.010	NA	0.056	NA	0.001	9.6e-01	NA	1.1e-02	NA	3.0e-01
5	GTEx	Brain Cerebellar Hemisphere	0.3860	0.1140	1.0e-03	-0.010	NA	0.012	NA	-0.009	7.2e-01	NA	1.6e-01	NA	6.4e-01
6	GTEx	Esophagus Muscularis	0.3160	0.0840	1.2e-03	0.136	NA	0.113	NA	0.145	1.2e-08	NA	2.5e-07	NA	4.1e-09
7	METSIM	Adipose	0.0387	0.0180	1.2e-02	0.011	-0.001	-0.002	0.001	0.007	8.2e-03	4.4e-01	7.2e-01	2.5e-01	3.1e-02
8	ROSMAP	Brain Pre-frontal Cortex	0.3117	0.0425	1.9e-15	0.113	0.148	0.169	0.160	0.149	2.4e-14	1.3e-18	3.3e-21	4.4e-20	1.1e-18
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.1216	0.0310	4.3e-12	0.053	0.109	0.111	NA	0.111	1.1e-06	2.9e-12	1.9e-12	NA	2.0e-12
10	TCGA	Brain Lower Grade Glioma	0.1096	0.0431	1.4e-03	0.019	0.027	0.031	NA	0.033	2.8e-03	4.7e-04	1.8e-04	NA	9.7e-05
11	TCGA	Testicular Germ Cell Tumors	0.2060	0.0800	1.9e-03	0.084	0.088	0.043	NA	0.047	6.8e-04	5.1e-04	1.2e-02	NA	9.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.7	1.1	3.2	-0.7	-1.0	-0.9	1.8	1.2	-0.2	0.0	1.7	0.9	-0.5	-1.1
Bipolar Disorder or Schizophrenia	0.7	1.8	6.9	-0.4	0.4	0.8	2.6	1.5	0.3	0.3	2.5	0.7	-0.2	-1.7
Depressed Affect (Nagel 2018)	0.5	1.0	5.2	-1.1	-0.1	0.1	-0.6	-1.1	0.4	-0.9	-0.8	-2.3	-1.1	0.2
Depression (Nagel 2018)	0.3	0.5	1.6	0.2	-0.2	-0.2	-1.3	-1.0	-0.1	-1.2	-0.2	-1.2	-0.1	-0.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.7	-0.9	-0.5	-0.6	-0.8	0.6	-1.2	0.9	0.6	-1.6	1.2	-1.3
Neuroticism (Nagel 2018)	0.2	0.4	1.3	-0.2	0.4	0.5	0.4	-0.6	1.2	-0.0	-0.2	-1.0	-0.9	0.0
Schizophrenia (2018)	0.6	1.3	3.3	0.0	1.4	1.7	1.7	1.1	0.5	0.4	1.8	0.2	0.1	-1.3
Schizophrenia vs Biploar Disorder	0.5	0.6	2.5	1.6	-0.2	-0.7	1.3	-0.1	-0.4	0.1	-0.4	0.6	-1.2	-0.4
Worry (Nagel 2018)	0.1	0.3	1.2	0.6	0.3	0.5	0.7	0.2	1.1	0.5	0.4	0.3	-0.1	0.3
Alzheimer’s Disease (in mother)	0.4	0.4	1.2	0.6	0.3	-0.2	0.2	0.8	-0.2	1.0	1.1	1.1	-0.3	-0.1
Alzheimer’s Disease (in father)	2.4	2.6	9.1	0.1	0.6	0.3	-0.6	-2.2	1.5	-0.0	-2.9	-0.2	-1.6	3.0
Alzheimer’s Disease (including proxy)	0.4	0.6	2.1	0.8	0.0	-0.5	-0.0	-1.5	-0.2	1.0	-1.1	-0.0	-0.3	1.2
Crohns Disease (2017)	0.2	0.5	1.7	-0.6	0.5	0.4	0.1	1.3	0.6	0.0	1.2	0.6	-1.0	0.3
Irritable Bowel Disease (IBD)	0.3	0.6	3.0	0.7	0.3	0.4	0.3	1.3	-0.2	0.7	1.7	0.8	-0.2	-0.2
Ulcerative Colitis (UC)	0.6	1.1	4.0	2.0	0.1	0.2	0.1	0.8	-0.8	1.4	1.6	1.1	0.9	-0.3
Major Depression (MDD)	1.3	1.5	3.5	-1.1	-1.6	-1.3	-0.8	-0.7	-1.1	-1.7	-0.7	-1.5	-1.9	0.1
Reaction Time	0.4	0.8	4.3	1.3	0.6	0.2	-2.1	0.7	0.2	-0.1	0.8	0.1	0.9	0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.2	-0.3	0.7	0.7	-0.0	1.4	0.2	1.5	1.4	0.0	0.4	-0.2
Breast Cancer	0.6	1.3	7.7	-2.8	-0.3	-0.5	-0.8	-0.1	0.3	-1.1	1.0	-1.1	-1.5	-0.6
Ovarian Cancer	0.4	0.5	3.7	-0.0	-0.2	0.0	0.0	-0.6	0.1	-1.9	0.5	-0.3	0.2	0.8
Prostate Cancer	0.5	0.7	2.1	-1.2	-0.4	-0.2	0.8	1.0	-0.8	0.2	0.6	-0.5	0.9	-1.4
Age at First Birth	1.1	1.6	8.4	2.9	0.7	0.4	-1.4	0.1	0.6	0.8	1.0	1.9	-0.2	1.2
Bipolar Disorder (2011)	1.4	1.4	6.0	-0.9	0.0	-1.3	-1.4	0.6	-0.6	-2.4	0.9	-1.6	0.9	0.1
Body Mass Index (BMI) (2010)	0.7	0.9	4.5	-2.1	-0.1	-0.0	-0.6	1.4	0.6	-1.5	0.3	-0.6	0.0	0.2
Coronary Artery Disease (CAD)	0.5	0.6	2.3	0.2	0.1	0.1	-1.3	-1.4	-0.3	0.4	-1.5	-0.4	0.4	0.2
Crohns Disease (2012)	0.4	0.6	1.4	-1.0	0.0	0.7	-0.6	-0.3	1.2	-1.0	-0.4	-0.7	0.2	1.1
Mean Putamen Volume	0.3	0.4	0.8	0.9	-0.8	-0.8	-0.5	0.7	-0.6	0.3	-0.3	0.3	-0.8	0.2
Fasting Glucose	1.3	1.6	3.5	-1.9	1.8	1.6	-1.6	-0.0	1.2	-0.3	-0.6	-1.2	-1.2	-0.7
HbA1C	0.7	0.8	3.2	1.2	0.5	0.2	-1.0	-1.8	0.2	1.1	-0.7	0.4	0.8	0.5
HDL Cholesterol	0.8	1.3	5.8	0.2	-0.8	-0.9	1.4	1.1	-1.4	-0.4	1.3	-0.1	0.3	-2.4
LDL Cholesterol	0.2	0.3	1.2	-0.5	-0.7	-0.4	1.1	-0.0	-0.6	-0.5	-0.4	-0.1	-0.5	0.1
Lupus	1.0	1.5	8.7	1.4	0.6	0.6	-2.9	0.6	0.0	-0.0	-1.0	-0.5	1.8	1.0
Neuroticism (2016)	0.8	1.2	8.0	0.2	0.2	0.1	2.8	1.3	0.3	-0.2	1.6	1.0	0.2	-0.1
Primary Biliary Cirrhosis	1.1	1.6	5.8	1.5	0.8	1.0	-1.1	0.3	1.2	0.0	-0.4	2.4	0.7	2.0
Rheumatoid Arthritis	0.5	0.6	1.6	-0.1	-1.0	-0.9	-1.0	0.4	-1.3	-0.4	-0.5	-0.6	-1.0	-0.8
Schizophrenia (2014)	0.5	1.1	3.3	0.2	1.2	1.4	1.3	1.1	0.5	-0.5	1.8	0.0	0.0	-1.4
Triglycerides	0.7	1.1	2.8	-0.9	-1.5	-1.4	-0.3	-1.1	-0.6	-1.0	-1.7	-0.7	-1.2	0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.9	3.1	0.5	0.1	0.1	1.7	1.8	-0.0	-0.5	1.7	0.1	-0.1	-0.1
Ulcerative Colitis	0.5	0.7	2.1	1.5	0.4	0.6	0.4	0.1	-0.5	0.2	1.4	0.3	1.4	-0.4
Blood Eosinophil Count	0.5	3.5	18.8	-0.1	-0.6	-1.4	1.6	4.3	-0.4	0.9	3.0	2.0	-0.8	-0.5
Blood Platelet Count	0.2	1.9	7.0	-2.6	-1.1	-1.1	0.7	2.2	-1.1	0.5	0.7	-0.8	-1.4	-1.1
Blood Red Count	0.1	1.2	3.6	-1.9	-0.7	-0.4	0.9	0.7	-0.7	-1.0	1.4	-1.4	-0.8	-1.0
Blood White Count	0.5	3.8	13.8	-3.7	-2.3	-2.8	1.1	1.6	-1.8	-1.2	0.7	-0.7	-1.9	-1.6
Heel T-Score	0.1	0.7	4.5	-0.4	-0.4	-0.3	0.1	-0.6	-0.4	-2.1	-0.1	-1.5	0.5	-0.0
BMI	0.6	3.5	21.7	-4.7	-0.9	-1.1	0.2	0.2	0.2	-2.0	-0.5	-1.2	-3.0	0.4
Height	0.8	15.8	90.4	9.5	2.9	2.1	1.0	1.4	-0.9	2.4	4.3	3.9	4.8	-1.9
Waist Hip Ratio (WHR)	0.3	1.2	4.7	1.5	-0.6	-0.8	2.2	0.7	-0.8	0.4	0.4	1.8	-0.5	-0.1
Systolic Blood Pressure	0.1	0.7	1.3	-1.0	-0.9	-0.7	1.1	-1.1	-0.6	-0.6	-1.1	-0.0	-1.1	0.2
Smoking Status	0.2	0.4	1.7	0.0	-1.1	-1.3	0.6	0.4	-0.4	-0.2	-0.3	0.1	-0.6	0.5
Allergy or Eczema	0.5	1.4	8.5	-0.3	1.2	1.3	-0.5	-0.2	1.1	1.1	-0.4	0.4	2.9	0.0
Cardiovascular Disease	0.1	0.2	1.0	-0.1	0.5	0.3	0.3	-0.3	0.5	-0.5	-0.1	-0.3	-0.2	1.0
Hypothyroidism (self reported)	1.0	2.2	10.3	1.0	0.0	-0.3	-0.3	3.2	0.9	0.4	1.1	2.8	-0.6	1.5
Respiratory disease	0.5	1.1	6.4	-2.5	0.5	0.7	1.1	0.9	1.1	0.5	0.7	-0.2	0.5	-0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.1	-0.5	1.0	0.9	1.8	1.2	1.0	0.0	1.2	0.7	-0.1	-0.1
Lung FEV1/FVC ratio	0.3	1.6	5.5	-0.8	-1.3	-1.3	0.8	2.1	0.3	-2.3	1.1	0.3	-1.0	0.9
Lung FVC	0.8	4.1	18.7	-2.4	-2.3	-1.9	0.0	-0.6	-1.6	-2.4	-0.8	-4.3	0.4	-1.7
Neuroticism	0.3	0.7	2.0	-1.1	0.1	0.2	-0.0	-0.6	1.4	-0.8	-0.4	-0.9	-0.6	1.3
Chronotype (morning person)	0.2	0.4	2.4	-0.2	-0.0	-0.2	-0.4	0.6	0.3	0.7	-1.5	0.3	-1.1	-0.0
Hair Pigment	0.0	0.5	1.5	-0.4	-0.6	-0.5	0.6	0.4	-0.6	-1.1	-1.2	-0.1	-0.0	-1.2
Tanning	0.1	1.8	6.8	1.1	1.0	1.1	-0.4	-0.2	1.6	-1.2	-0.2	0.1	2.4	2.6
Hand grip strength (left)	0.5	1.2	8.2	-0.8	-0.5	-0.3	2.9	-0.4	-1.0	-1.1	0.1	-1.2	0.2	-0.1
Number of treatments/medications taken	0.3	0.6	1.3	-0.6	-0.9	-1.1	1.1	0.8	-0.5	-0.8	-0.4	-0.6	-0.2	-0.8
Average weekly spirits intake	1.9	2.4	7.5	0.1	0.5	0.5	2.1	2.0	1.5	0.0	1.0	2.7	-1.6	2.0
Sensitivity / hurt feelings	0.6	1.0	4.1	0.2	-0.3	-0.7	-0.3	0.9	0.8	1.4	0.7	2.0	-0.7	1.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.1	-0.0	-0.8	-0.8	-0.7	-0.9	-0.9	-1.0	-0.3	-1.1	0.4	-0.9
Hearing difficulty/problems: Yes	1.0	1.5	4.7	0.2	-1.7	-1.8	-1.0	-0.8	-2.2	-0.1	-0.6	-1.6	0.6	-0.9
Relative age of first facial hair	0.6	1.2	3.7	0.7	-0.5	-0.8	1.4	-0.1	-1.4	0.6	1.4	-0.7	1.9	-1.2
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	5.2	0.7	-0.5	-0.4	0.3	1.9	0.6	0.4	0.9	2.3	-0.2	2.1
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	0.4	-0.8	-1.2	-1.2	-0.6	0.2	1.3	-1.4	1.4	-0.2	1.4
Ever had hysterectomy (womb removed)	0.6	0.7	2.7	0.4	-0.3	-0.4	-1.2	-0.8	0.3	-1.6	-0.6	-0.1	-0.4	1.6
Systolic blood pressure, automated reading	0.5	1.4	5.0	-2.1	-0.9	-0.6	0.5	-0.6	-0.3	-1.6	-1.1	-0.0	-2.2	0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.5	0.6	-0.8	-1.0	1.6	-0.6	-0.8	0.7	0.0	0.9	-0.9	-1.1
Angina	1.0	1.3	3.9	0.6	2.0	1.8	0.1	0.6	1.6	1.6	0.2	1.1	0.4	-0.4
Medication for hormone replacement therapy	0.5	0.5	1.9	0.3	-1.4	-1.3	-0.0	-0.5	-0.5	-0.4	-0.7	-0.1	-0.4	0.9
Vitamin and mineral supplements	0.8	1.0	3.9	-1.5	-0.2	-0.2	-0.7	-0.8	-0.5	-0.4	-1.0	-2.0	0.5	-1.5
Supplements: Zinc	1.4	1.5	3.8	-1.9	1.3	1.4	0.4	0.6	1.5	0.4	0.4	-0.1	1.6	1.8
Medication: Co-codamol	2.2	2.6	6.2	-1.6	-1.1	-0.5	-0.9	-2.2	-0.7	-2.5	-1.9	-2.3	-1.8	0.2
Medication: Metformin	0.7	1.0	4.1	-0.8	0.0	-0.0	2.0	0.7	0.1	-1.0	0.7	-0.2	-1.3	-1.5
Diabetes (father)	0.6	0.7	2.0	0.8	0.3	0.4	0.1	1.4	-0.5	0.8	0.7	1.2	0.6	-1.2
Diabetes (mother)	1.9	2.4	12.0	0.0	-0.7	-0.4	-0.6	-0.9	1.0	-0.4	-1.2	2.3	-2.3	3.5
Severe depression (siblings)	0.5	0.6	2.0	-1.1	-1.1	-0.9	0.1	-0.4	-0.6	-0.3	-0.2	-1.4	-0.1	-0.6
Pack years adult smoking proportion	0.4	0.6	1.5	-0.6	0.6	0.5	1.2	0.3	0.2	1.2	1.2	0.5	0.7	-0.7
Impedance of leg (right)	0.3	1.5	5.9	1.9	0.2	-0.0	-0.1	-0.9	0.1	2.2	-0.9	2.4	0.6	0.5
Leg fat-free mass (left)	0.2	1.1	2.9	-0.1	-0.5	-0.5	1.7	-0.0	-1.1	-1.6	1.0	-1.0	-1.6	-1.0
Trunk fat percentage	0.2	1.0	6.2	-0.9	-0.6	-1.0	0.9	-0.6	-0.0	-0.2	-1.0	0.3	-2.5	0.1
Hand grip strength (right)	0.3	0.8	5.6	-0.3	-0.2	-0.0	2.4	-0.9	-0.2	-0.9	-0.2	-0.6	0.4	0.8
Townsend deprivation index at recruitment	0.8	1.1	5.8	0.2	-0.7	-0.9	-2.4	-0.1	-0.2	1.3	-1.4	0.3	0.6	1.2
Current tobacco smoking	0.2	0.4	2.0	1.4	-0.3	-0.3	-0.4	0.8	-0.2	-0.3	0.2	0.0	0.3	0.9
Average weekly fortified wine intake	0.5	0.6	1.6	0.1	-1.3	-1.2	1.1	0.5	-0.8	0.5	-0.8	0.5	0.2	-0.1
Maternal smoking around birth	1.3	1.9	6.5	0.8	-0.1	0.1	-0.9	-2.6	0.8	1.4	-2.1	0.5	1.2	2.0
Fed-up feelings	0.7	1.4	4.1	-0.5	-1.2	-0.9	0.9	-0.9	-1.1	-1.9	-0.5	-2.0	-1.1	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	4.9	0.4	-2.0	-2.0	-0.7	-0.6	-2.2	-1.0	-0.3	-1.6	0.6	-1.5
Relative age voice broke	0.5	0.7	3.6	0.8	-0.6	-0.4	1.9	0.3	-0.7	-0.3	1.5	0.2	0.3	0.1
Taking other prescription medications	0.5	0.8	2.1	1.1	-0.1	-0.3	0.5	1.4	0.3	-1.5	1.2	0.7	1.0	0.3
Age when periods started (menarche)	0.4	0.9	2.2	1.5	0.8	0.6	-0.1	1.3	0.6	-0.7	1.4	0.4	-1.2	-0.7
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	4.7	0.5	-2.2	-2.1	-0.1	-0.7	-1.1	-1.5	-1.8	-0.2	-1.5	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.3	0.3	-1.1	-1.2	-0.4	0.6	-1.1	-1.8	0.9	-1.4	-0.8	-0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	3.2	-0.7	0.7	0.8	0.6	0.1	0.9	-1.8	0.2	-1.8	-0.4	-0.3
Qualifications: CSEs or equivalent	0.4	0.6	1.5	-0.6	-1.0	-1.2	0.8	0.2	-0.2	-0.5	-0.9	1.0	-0.5	-0.2
Serious illness, injury or assault to yourself	1.6	1.9	5.4	1.9	0.4	0.3	-0.8	1.6	1.2	-0.3	1.1	2.3	1.4	2.0
High blood pressure	0.1	0.3	1.3	-0.4	0.2	0.1	0.6	-0.6	0.3	0.1	-1.1	-0.3	-1.1	0.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	5.3	-0.5	0.2	0.4	-0.9	-0.4	0.1	-0.1	-0.6	-0.6	2.3	0.3
Multivitamins +/- minerals	0.8	1.0	5.1	0.4	-0.3	-0.4	0.9	0.7	0.1	0.8	1.4	2.2	-0.8	1.1
Stomach or abdominal pain in last month	1.2	1.5	3.9	-1.0	0.5	0.5	-2.0	-0.8	1.1	1.7	-1.4	0.8	1.4	1.2
Supplements: Glucosamine	1.0	1.3	5.4	-1.3	-0.9	-0.9	-1.2	-0.4	-0.5	-2.3	-0.7	-1.6	-0.3	0.9
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.6	-0.5	-1.7	-1.9	-1.2	0.0	-1.2	-1.4	-0.7	-0.3	0.2	0.1
Medication: Atenolol	0.6	0.8	1.8	-1.2	0.6	0.5	-0.3	0.6	0.9	0.9	-1.3	1.0	1.3	-0.1
Medication: Levothyroxine sodium	1.4	2.5	9.1	2.2	-0.0	-0.4	0.4	2.4	0.8	0.1	1.5	3.0	0.9	1.7
Sitting height	0.0	0.2	0.8	0.1	-0.3	-0.1	-0.5	-0.5	-0.4	-0.3	0.5	-0.9	0.5	-0.5
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	-1.1	-1.4	-1.1	-0.7	-0.2	-0.6	-0.6	-1.0	-0.8	0.2	0.4
High blood pressure (mother)	0.7	1.0	5.5	-0.8	-0.3	0.0	1.1	-1.0	0.1	-1.3	-1.1	-0.1	-2.3	0.2
Body mass index (BMI)	1.0	4.4	13.4	-3.4	-2.0	-2.1	1.1	0.0	-1.2	-2.8	-0.6	-2.0	-3.7	-0.8
Impedance of leg (left)	0.5	2.5	8.6	2.7	0.2	-0.2	-0.0	-0.8	0.1	2.8	-0.9	2.9	1.1	0.8
Leg predicted mass (left)	0.2	1.1	2.8	-0.0	-0.5	-0.5	1.7	-0.1	-1.1	-1.5	1.0	-1.0	-1.6	-0.9
Trunk fat mass	0.3	1.2	6.5	-0.7	-1.0	-1.3	1.2	-0.5	-0.7	-0.8	-0.5	-0.1	-2.5	-0.5
Waist circumference	0.5	1.8	8.2	-1.1	-1.5	-1.8	1.2	0.5	-1.2	-1.2	0.0	0.1	-2.9	-0.5
Number of incorrect matches in round	1.1	1.8	5.5	-0.7	2.3	2.3	-0.4	0.9	2.3	0.7	0.7	0.5	0.9	0.6
Past tobacco smoking	0.3	0.6	1.3	0.9	0.0	0.0	-0.9	1.1	-0.2	0.5	1.1	0.8	1.1	0.2
Alcohol usually taken with meals	0.3	0.5	1.6	-0.1	-0.9	-0.4	1.3	-0.3	-0.6	-1.1	-0.2	-0.9	-0.3	-0.3
Nervous feelings	0.3	0.5	1.6	0.0	-0.2	-0.3	0.9	1.3	0.5	0.3	1.1	0.8	-0.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.4	-0.2	0.0	0.5	-1.0	-0.6	0.1	-1.2	0.0	-0.9	-0.1	0.6
Hearing difficulty/problems with background noise	0.9	1.5	5.1	-1.2	-0.7	-0.9	-1.7	-2.2	-0.7	-0.2	-1.5	-1.6	-0.1	-0.4
Hair/balding pattern: Pattern 2	1.0	1.3	7.7	-0.9	-0.5	-0.6	-2.0	0.1	-0.1	-0.6	0.1	0.3	0.6	2.8
Had menopause	1.1	1.4	7.7	2.8	0.3	-0.1	-0.7	0.9	0.0	0.2	1.2	2.1	0.2	0.7
Had other major operations	1.0	1.2	4.7	-2.2	-0.2	-0.0	1.3	1.9	0.3	-0.3	1.5	-0.3	0.6	-0.8
Forced vital capacity (FVC)	0.5	2.0	4.9	0.4	-1.5	-1.4	1.9	-1.4	-1.7	-1.1	-0.6	-2.2	0.7	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.8	0.8	-0.2	-0.1	0.5	0.3	-0.7	-0.5	1.7	-0.5	0.5	-1.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	5.4	-0.6	0.4	0.4	-0.3	-0.7	-0.7	-0.8	-0.3	-2.3	-1.0	-1.6
Qualifications: None of the above	1.5	3.3	13.4	-0.1	1.2	1.0	-2.9	-1.6	2.5	-0.5	-1.8	0.6	0.1	3.7
Financial difficulties in last 2 years	0.8	1.1	3.1	0.8	-1.5	-1.7	-0.0	1.5	-1.7	0.3	0.4	0.1	-0.2	-1.0
Mouth/teeth dental problems	0.6	1.0	3.6	-1.3	-0.2	0.2	-1.1	-0.8	-0.5	-0.2	-1.6	-1.9	0.2	-0.9
Heart attack	0.8	1.0	4.4	-1.1	1.3	1.2	-2.1	-0.7	1.3	-0.3	-0.1	0.1	0.5	0.0
Allergy	0.4	0.9	4.8	1.3	-0.7	-1.1	0.1	-0.2	-0.6	0.1	-0.0	0.9	-2.2	-0.1
Pain all over the body in last month	0.7	0.8	2.4	1.5	-0.9	-0.8	-0.3	-0.7	-0.5	0.1	-0.5	1.1	-0.3	1.5
Diabetes (self-reported)	1.1	1.7	8.2	-0.8	1.2	1.0	2.9	1.3	1.3	-0.8	1.2	1.3	-0.6	-0.1
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	7.5	2.1	1.4	1.7	1.4	1.1	1.6	1.4	0.4	2.7	1.8	1.2
Medication: Ramipril	0.4	0.6	1.6	0.2	0.4	0.2	-0.9	0.6	-0.4	-0.8	0.9	-0.7	1.0	-1.3
Medication: Simvastatin	0.2	0.4	0.9	0.9	0.5	0.2	0.2	-0.6	0.5	0.6	-0.5	0.7	-0.9	0.4
Fluid intelligence score	0.5	1.0	3.2	-0.5	1.0	1.1	-0.5	0.8	1.1	1.8	0.5	1.2	0.7	0.9
Illnesses of siblings	0.8	1.1	4.6	0.9	2.1	1.8	-0.2	-0.4	1.2	-0.4	0.0	-1.1	-0.2	-0.6
Neuroticism score	0.3	0.6	1.7	-1.3	0.0	-0.0	0.8	0.1	1.2	-0.9	0.2	-0.3	-0.8	0.8
Weight	0.4	1.9	6.0	-0.4	-1.3	-1.5	1.7	0.1	-1.5	-1.7	0.6	-0.6	-2.5	-1.3
Impedance of arm (right)	1.7	7.8	20.4	4.4	2.8	2.4	0.3	-0.3	2.0	4.5	0.1	4.1	3.1	1.4
Arm fat percentage (right)	0.3	1.3	5.2	-1.9	-0.6	-0.8	1.2	-0.5	-0.1	-1.0	-1.0	-0.6	-2.3	-0.0
Trunk fat-free mass	0.5	2.8	6.5	0.9	-1.5	-1.5	1.8	0.8	-2.5	-2.1	2.1	-1.0	-1.0	-2.0
Hip circumference	0.2	1.0	2.4	-1.1	-1.3	-1.5	-0.2	-0.1	-1.1	-1.2	0.1	-0.7	-1.5	-0.6
Time employed in main current job	1.1	1.3	6.5	0.5	-0.9	-0.8	-0.1	0.9	-1.1	0.6	1.3	-0.8	2.6	-1.0
Alcohol intake versus 10 years previously	0.8	1.2	3.6	-0.2	1.9	1.6	-1.0	-0.4	1.7	-0.6	0.9	0.1	-1.2	-0.3
Father’s age at death	2.4	3.2	12.2	-0.5	3.5	3.2	-0.4	1.7	2.4	0.4	1.5	0.4	-0.3	-0.7
Worrier / anxious feelings	0.3	0.6	1.6	0.0	0.2	0.6	0.7	0.8	1.0	0.1	1.1	0.5	1.3	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.6	0.3	-0.9	-0.8	0.5	-0.3	-1.3	-0.0	0.1	-0.2	-0.6	-1.1
Falls in the last year	0.4	0.5	3.1	-0.8	0.3	0.4	-1.8	0.4	-0.1	-0.9	-0.3	-0.2	-0.1	0.5
Hair/balding pattern: Pattern 3	1.1	1.6	8.8	0.7	0.6	0.9	-0.1	-3.0	1.0	1.0	-2.3	-0.2	0.0	-0.7
Number of live births	0.8	1.1	3.1	-1.7	-0.9	-0.6	0.8	1.2	-0.4	-1.6	0.4	-1.8	-0.6	0.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	6.1	0.1	-2.1	-1.9	1.5	-1.1	-1.8	-2.0	-0.8	-2.5	0.5	-1.2
Pulse rate	1.4	2.4	9.3	-2.1	-1.3	-1.3	-0.5	-1.4	-1.8	-1.4	0.0	-3.1	-1.3	-0.9
Happiness	1.2	1.5	5.4	1.1	1.1	1.1	0.7	1.2	0.0	1.1	2.3	0.5	1.4	-1.4
Noisy workplace	1.0	1.2	4.6	-0.7	0.3	0.3	-0.8	-0.4	0.9	-1.9	-1.0	0.2	-2.1	1.3
Qualifications: A levels/AS levels or equivalent	0.5	1.2	4.5	-1.0	1.3	1.5	2.1	-0.8	1.3	0.9	0.2	0.4	0.5	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	5.8	0.7	-2.1	-2.1	-0.2	0.3	-2.4	-2.3	0.0	-1.0	-1.0	-0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	3.5	1.2	0.3	0.3	-0.7	0.1	0.7	-0.3	0.4	1.8	-1.1	1.9
Asthma	0.6	1.2	5.9	-2.4	0.6	1.1	1.0	0.9	0.9	1.1	0.3	-0.5	1.0	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.1	-1.5	-1.1	-1.3	1.0	-0.2	-0.2	-0.3	0.0	0.7	-0.2	0.1
Medication: Cholesterol lowering	0.4	0.6	1.4	0.1	0.9	0.8	0.8	-0.1	1.1	1.2	0.2	0.7	0.8	-0.9
Depression (self-reported)	0.2	0.3	1.0	1.0	-0.2	-0.3	-0.6	0.2	-0.3	0.1	0.7	0.3	1.0	0.1
Medication: Lansoprazole	1.1	1.3	4.8	-0.5	-0.0	-0.4	0.5	-0.7	-0.5	-2.0	-1.1	-2.2	-0.6	-1.6
Prospective memory result	0.5	0.6	1.7	-0.6	0.9	0.6	0.4	1.3	0.6	0.6	1.2	0.4	1.2	-0.3
Lung cancer (father)	1.3	1.6	5.2	-1.2	-0.6	-0.6	-0.4	-1.4	-1.1	1.0	-0.7	-2.3	1.8	-1.3
Illnesses of mother	0.8	1.0	2.8	-0.9	-0.4	-0.6	-0.4	-0.0	-1.1	0.0	0.7	-1.6	1.7	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.2	-0.2	-1.3	-1.2	1.2	-0.1	-1.4	-1.5	0.2	-2.0	0.5	-1.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.9	1.1	-0.4	-0.8	0.2	0.3	-0.6	0.5	1.4	1.2	-0.4	0.4
Impedance of arm (left)	1.6	7.4	21.6	4.2	2.7	2.2	-0.2	-0.4	2.0	4.6	-0.2	4.0	2.7	1.7
Arm fat mass (right)	0.6	2.3	7.0	-1.8	-1.6	-1.8	1.4	-0.1	-1.3	-1.9	-0.5	-1.1	-2.6	-0.7
Trunk predicted mass	0.5	2.7	6.5	1.0	-1.6	-1.5	1.8	0.7	-2.5	-2.1	2.0	-1.0	-1.0	-1.9
Standing height	0.6	6.2	39.3	6.3	1.0	0.6	1.6	0.2	-1.3	1.5	2.5	2.8	2.3	-1.3
Length of working week for main job	0.4	0.4	1.3	-0.8	-0.4	-0.4	0.4	0.4	0.4	0.0	0.2	0.9	-1.2	1.0
Exposure to tobacco smoke at home	0.4	0.4	2.1	-1.4	-0.2	-0.4	0.1	0.3	-0.2	-0.3	0.6	-1.2	-0.5	-0.4
Breastfed as a baby	0.4	0.4	1.4	0.0	0.4	1.0	-0.9	-0.5	0.4	0.2	-1.2	-0.5	0.6	0.7
Tense / ‘highly strung’	0.3	0.4	1.8	-0.5	0.6	0.6	0.5	0.6	1.4	-0.1	-0.3	0.5	-1.0	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	6.9	-2.6	-1.1	-0.9	0.4	0.9	-0.6	-2.0	1.4	-2.5	-0.2	-0.7
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	-1.1	-0.7	-0.6	-0.1	0.5	-0.9	0.6	-0.1	-0.7	1.0	-0.8
Birth weight of first child	1.0	1.9	7.6	-2.3	-0.3	-0.2	1.0	-1.5	-0.2	-0.3	-1.4	-2.7	-1.3	-0.9
Peak expiratory flow (PEF)	1.5	3.5	9.7	-0.3	-3.1	-3.1	1.9	0.3	-2.3	-2.1	-0.2	-1.3	-0.1	-1.9
Pulse wave reflection index	0.9	1.1	3.6	1.7	-0.5	-0.8	-0.1	1.9	-0.0	-0.5	1.4	1.5	-0.7	0.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.3	-0.9	0.9	1.1	-0.6	-1.7	0.6	-1.2	-1.8	-0.9	-1.1	0.0
Loud music exposure frequency	0.2	0.2	1.3	0.0	-0.3	-0.2	0.8	-0.2	-0.5	0.1	0.0	-1.1	0.0	-0.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	6.1	1.0	-0.0	-0.3	0.8	-1.0	-0.3	2.5	-0.4	1.3	0.7	-0.2
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	5.0	1.1	0.5	0.4	2.2	1.9	-0.5	-1.5	2.2	-0.9	0.7	-1.8
Blood clot in the leg (DVT)	0.7	0.9	2.4	0.3	1.6	1.4	1.2	-1.2	0.9	0.5	-0.2	0.8	0.7	0.5
Medication: Paracetamol	0.5	0.9	4.6	-0.8	0.2	-0.1	-0.5	-0.3	1.0	-0.2	-1.3	0.6	2.2	0.9
Headache pain in last month	0.2	0.3	0.9	-0.4	0.0	-0.2	-0.3	-0.8	0.4	-0.9	0.4	0.5	0.3	0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.0	1.0	-0.5	-0.3	-0.2	0.7	-0.8	-0.6	0.2	0.5	-1.0	0.5
Glaucoma (self-reported)	0.4	0.5	3.0	0.0	0.1	0.4	0.7	0.1	0.1	-1.7	0.2	-1.0	0.3	0.2
Gout (self-reported)	0.7	1.0	3.8	-0.3	-1.2	-1.4	0.7	0.0	-1.2	-1.2	0.1	0.4	-1.9	-0.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	10.0	1.5	-0.3	-0.7	0.0	3.2	0.7	0.0	1.2	3.1	-0.3	1.7
Medication: Amlodipine	0.5	0.7	1.9	-1.4	0.5	0.5	0.5	0.5	1.0	0.4	-0.6	-0.8	-1.2	-1.2
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.8	-0.3	-1.6	-1.2	-0.7	1.7	-1.4	-0.1	0.8	-1.0	0.3	-1.1
Birth weight	0.2	0.5	1.3	0.8	0.8	0.8	-0.6	-0.3	1.2	-0.4	0.4	0.7	-0.6	0.8
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.2	1.3	-1.6	-1.3	0.8	-0.8	-1.8	-0.0	0.1	-0.9	-0.0	-1.1
High blood pressure (siblings)	0.3	0.5	2.2	-0.7	-1.5	-1.1	0.2	0.1	-1.0	-0.2	-0.5	0.2	0.1	-0.5
Forced vital capacity (FVC), Best measure	0.4	1.4	3.5	0.4	-1.2	-1.1	1.4	-0.2	-1.6	-0.9	0.4	-1.9	1.5	-1.3
Body fat percentage	0.4	1.4	7.1	-1.6	-1.0	-1.3	1.0	-0.7	-0.3	-0.5	-1.1	-0.1	-2.7	-0.1
Leg fat percentage (right)	0.9	3.2	10.8	-2.9	-1.9	-2.0	1.0	-0.7	-1.1	-1.7	-1.2	-0.9	-3.3	-0.6
Arm fat-free mass (right)	0.5	2.5	5.6	-0.3	-1.9	-1.9	1.5	0.1	-2.2	-2.4	0.9	-1.2	-2.0	-1.4
Exposure to tobacco smoke outside home	0.7	0.9	3.8	-1.6	0.5	0.8	0.7	0.5	1.3	0.1	0.1	0.6	-0.7	1.9
Comparative body size at age 10	0.3	0.8	3.1	-0.5	0.1	-0.3	-1.8	-1.1	0.7	1.2	-1.4	-0.5	0.5	0.6
Number of full brothers	0.5	0.7	3.8	-2.0	-1.1	-1.0	0.2	-0.0	-0.3	0.0	-0.3	0.3	-0.8	0.4
Worry too long after embarrassment	0.4	0.6	3.5	-1.9	0.4	0.5	0.9	-0.3	1.1	0.9	-0.4	-0.0	0.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.0	-0.5	-0.4	-0.6	-1.0	1.3	-0.1	-0.4	1.4	-0.5	-0.0	0.0
Wheeze or whistling in the chest in last year	0.3	0.5	1.4	-0.1	0.3	0.4	-0.7	1.0	0.3	1.1	0.5	0.9	1.2	0.5
Number of children fathered	1.3	1.5	4.8	-2.2	1.6	1.7	0.7	-0.6	1.8	0.6	0.0	0.1	-1.1	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	5.3	0.5	0.4	0.5	0.3	-0.3	0.1	0.9	-1.0	-0.3	2.3	-0.5
Age at first live birth	1.4	2.5	8.1	1.1	0.9	0.6	-0.1	2.0	0.7	1.3	2.8	1.8	2.3	1.5
Pulse wave peak to peak time	0.3	0.4	1.4	-0.4	0.6	1.0	-0.1	-0.3	0.6	-0.0	-1.2	-0.7	0.6	-0.3
Health satisfaction	0.3	0.4	1.6	0.1	-1.3	-1.0	0.3	-0.6	-1.0	-0.1	0.1	0.4	0.0	-0.5
Shortness of breath walking on level ground	1.2	1.5	2.9	-1.7	1.1	1.5	-1.3	-1.0	1.2	-0.6	-1.4	-1.2	-1.3	0.3
Qualifications: College or University degree	0.2	0.7	2.3	0.3	1.1	1.2	0.2	-0.4	0.0	1.5	1.1	-0.6	0.3	-1.1
Eye problems/disorders: None of the above	0.5	0.6	1.3	0.2	-0.7	-0.9	-0.9	-1.1	-0.8	-0.7	-0.2	-1.1	0.5	0.4
Mouth/teeth dental problems: Loose teeth	1.8	2.2	7.2	-0.5	1.8	1.1	1.0	1.1	1.6	2.7	1.4	2.2	0.7	0.1
Emphysema/chronic bronchitis	0.9	1.0	3.0	-0.3	0.9	0.9	0.7	1.0	1.2	-0.3	0.9	1.0	-1.7	1.1
Medication for pain relief, constipation, heartburn	0.5	0.8	3.1	0.3	-1.1	-0.6	0.1	-0.2	-1.8	-0.1	0.3	-1.3	-1.4	-0.7
Neck or shoulder pain in last month	0.7	1.0	3.6	-1.9	-0.1	0.1	0.7	-0.1	0.5	1.7	-1.0	1.4	0.5	0.4
Medication: Blood pressure	0.4	0.7	3.3	-1.8	-0.1	-0.1	-0.5	-0.3	0.4	0.0	-0.2	-1.2	1.1	-0.7
Angina (self-reported)	1.2	1.6	4.8	0.8	2.2	2.0	0.2	0.6	1.9	1.6	0.3	1.3	0.4	-0.2
Migraine (self-reported)	1.6	1.9	9.2	-0.1	0.8	0.5	-3.0	-1.1	1.2	-0.4	-1.8	1.2	0.1	2.0
Medication: Ibuprofen	0.4	0.5	1.5	-1.2	-1.0	-1.2	0.5	-0.5	-0.5	-0.2	-0.1	0.4	-0.1	-0.4
Medication: Allopurinol	1.1	1.4	4.5	-0.3	-2.0	-2.1	0.5	0.1	-1.8	-1.0	0.1	-0.4	-1.3	-0.9
Medication: Omeprazole	1.0	1.1	3.0	-1.7	1.3	1.3	-0.1	0.6	1.7	0.5	-0.6	0.6	-1.3	0.5
Medication: Seretide 50 evohaler	0.6	0.7	2.1	-1.4	0.8	1.1	-0.4	-0.5	1.1	1.2	-0.3	-0.2	0.9	0.5
Mean time to correctly identify matches	0.7	1.3	5.6	1.7	0.8	0.5	-2.4	0.2	0.6	0.6	0.5	0.4	1.1	1.5
Heart disease (mother)	1.5	1.8	8.6	-0.7	0.9	1.0	-1.0	2.9	1.0	-0.7	1.9	0.7	-1.5	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	3.3	0.8	-0.3	-0.1	1.7	-0.9	-0.5	-0.2	0.2	0.4	1.8	-0.5
Whole body fat mass	0.5	1.9	7.8	-1.6	-1.4	-1.6	1.4	-0.3	-1.0	-1.4	-0.5	-0.7	-2.8	-0.7
Leg fat mass (right)	0.8	3.1	10.8	-2.4	-1.6	-1.8	1.7	-0.5	-1.3	-2.0	-0.6	-1.1	-3.3	-1.0
Arm predicted mass (right)	0.4	2.1	4.1	-0.3	-1.7	-1.6	1.6	-0.0	-1.9	-2.0	0.7	-1.4	-1.9	-1.3
Pulse rate, automated reading	0.7	2.3	7.9	-2.5	-1.6	-1.5	-0.4	-1.0	-1.8	-0.8	-0.4	-2.8	-0.6	-1.0
Alcohol intake frequency.	0.5	1.1	3.7	0.0	0.6	0.5	-1.3	-1.0	0.9	-0.3	-1.4	1.0	-1.9	1.0
Comparative height size at age 10	0.5	3.0	19.2	4.4	1.3	1.0	0.6	0.0	0.0	1.4	0.5	2.7	1.0	-0.4
Number of full sisters	1.2	1.5	4.6	-1.2	-1.2	-0.7	0.2	-1.5	-0.2	-1.7	-1.4	-2.1	-0.8	0.4
Suffer from ‘nerves’	0.3	0.5	2.6	-1.6	-0.1	-0.2	0.7	-0.1	0.9	0.8	-0.0	-0.3	-0.5	0.3
Overall health rating	0.4	0.8	3.1	0.4	-0.2	0.1	0.9	1.4	0.3	0.3	1.4	1.7	0.3	-0.4
Chest pain or discomfort	0.7	1.0	3.1	0.2	1.3	1.3	-0.8	0.1	1.8	1.1	0.4	0.9	-0.3	1.3
Had major operations	1.0	1.1	3.5	-1.4	0.7	0.9	-0.6	-0.8	1.3	1.9	-1.0	0.6	0.7	1.2
Age at last live birth	1.0	1.4	4.4	0.7	0.4	0.3	-1.2	0.9	0.6	1.4	0.9	1.3	1.7	2.1
Family relationship satisfaction	1.1	1.4	4.0	0.9	1.4	1.3	0.2	1.3	1.2	0.5	2.0	1.5	-0.2	0.8
Leg pain on walking	0.3	0.4	1.6	-0.1	-0.5	-0.5	0.3	-0.4	0.1	-1.3	-0.3	0.8	-0.5	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.3	-1.0	-0.4	-0.1	1.8	-0.2	-0.1	-0.5	-0.3	0.4	-1.5	0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.5	2.2	-1.5	0.1	0.3	0.5	0.2	0.0	-0.1	0.6	-1.5	0.6	0.5
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	4.8	-2.2	1.9	1.9	0.2	-0.8	1.1	0.7	0.3	-1.4	-1.4	-1.6
Medication: Aspirin	2.2	2.9	7.9	2.5	2.8	2.3	-0.4	0.5	2.2	1.0	1.2	2.0	0.1	0.9
Supplements: Vitamin C	1.7	2.0	5.9	1.5	2.4	2.4	1.5	1.0	1.5	-0.1	1.1	0.1	0.8	1.1
Knee pain experienced in last month	0.4	0.6	2.4	0.3	-0.8	-0.7	1.5	0.3	-1.3	-0.1	1.0	0.5	0.3	-0.0
Hypertension (Self-reported)	0.1	0.3	0.9	-0.9	0.3	0.2	0.6	-0.5	0.4	0.1	-0.9	-0.5	-0.9	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.0	-0.1	1.4	1.2	0.3	1.3	1.1	1.0	0.7	0.9	-0.7	-0.7
Illnesses of father: Heart disease	1.0	1.4	4.6	1.8	0.2	0.1	1.1	-1.0	0.7	1.4	-0.5	2.2	0.8	1.3
Illnesses of siblings: Diabetes	0.6	0.7	2.4	-1.1	-1.2	-1.0	-0.0	0.2	-0.5	0.3	0.4	0.3	0.8	1.6
Smoking status: Previous	0.5	0.7	2.0	-1.2	0.5	0.4	1.1	-1.0	0.4	-0.3	-0.5	-0.1	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	7.2	2.7	-0.4	-0.6	-0.2	-0.5	-1.2	-1.9	0.3	-0.7	-0.4	-1.0
Whole body fat-free mass	0.4	2.0	4.0	0.6	-1.2	-1.2	1.9	0.4	-2.0	-1.9	1.6	-1.0	-1.3	-1.6
Leg fat-free mass (right)	0.1	0.8	2.4	0.5	-0.5	-0.5	1.5	0.2	-1.0	-1.2	1.1	-0.7	-1.1	-0.6
Arm fat percentage (left)	0.4	1.4	6.2	-2.1	-0.6	-0.9	1.0	-0.7	0.0	-0.7	-1.2	-0.6	-2.5	0.1
Average weekly red wine intake	0.3	0.4	1.3	0.4	0.3	0.4	1.0	0.7	0.4	0.2	0.4	1.1	0.3	1.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.4	0.8	-0.5	-0.6	0.5	1.5	-1.3	-0.9	1.9	-0.3	-0.0	-0.3
Mood swings	0.2	0.4	0.9	-0.9	0.1	0.4	-0.8	-1.0	0.7	-0.8	-0.2	-0.7	0.2	0.7
Loneliness, isolation	0.3	0.4	1.3	-1.1	0.6	0.6	-0.4	-0.4	1.1	-0.4	-0.4	-0.3	-0.7	0.2
Long-standing illness, disability or infirmity	0.6	1.0	2.4	0.7	-1.4	-1.4	1.6	-0.0	-0.5	-0.2	0.6	1.5	0.2	1.0
Ever had bowel cancer screening	0.7	0.8	5.1	-1.2	0.4	0.2	-2.3	-0.3	0.6	-1.1	-0.3	0.1	-0.6	0.2
Diabetes diagnosed by doctor	1.0	1.6	10.3	-0.5	0.1	-0.0	3.2	1.2	-0.0	-0.7	1.7	0.6	-0.3	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.9	-0.8	-0.8	-0.6	0.9	-0.5	-1.2	-0.4	-0.4	-1.4	-0.2	-0.8
Friendships satisfaction	0.8	1.0	8.9	3.0	-0.0	-0.0	0.6	-0.4	-0.5	-0.7	0.4	0.5	0.1	-0.7
Qualifications: nursing, teaching	0.1	0.2	0.8	0.3	-0.6	-0.9	0.2	-0.1	-0.6	0.2	0.1	-0.2	0.5	-0.1
Commuting to job workplace: Walk	2.1	2.3	13.3	1.5	-0.7	-1.0	0.2	1.0	-0.0	2.5	0.1	3.6	0.3	1.0
Eye problems/disorders: Cataract	0.3	0.4	1.1	1.0	-0.1	0.2	0.7	0.5	-0.0	0.8	-0.1	1.1	-0.7	0.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	5.4	1.7	-0.8	-1.2	-0.0	-0.4	0.4	-0.2	0.9	2.3	-0.4	2.3
Medication for cholesterol	0.6	0.9	2.8	-1.7	0.6	0.8	-0.4	-0.6	0.9	-0.2	0.7	-1.3	1.4	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	4.7	1.7	-0.4	-0.8	0.7	0.2	-0.1	0.4	-0.5	2.2	-0.8	1.1
Back pain experienced in last month	0.4	0.6	2.1	0.9	1.3	1.4	-0.1	-0.1	0.8	0.4	-0.2	0.8	0.4	-0.8
Mineral and other dietary supplements	0.6	0.8	3.6	1.9	0.7	0.5	-0.2	-1.2	0.4	0.2	-0.3	1.1	1.1	-0.5
Breast cancer (self-reported)	0.8	0.9	3.2	1.8	-1.0	-1.0	-1.0	0.1	-1.1	0.9	-0.2	1.0	0.2	-0.9
Asthma (self-reported)	0.6	1.2	7.1	-2.7	0.5	1.0	1.0	0.5	0.9	1.4	-0.1	-0.4	0.6	0.3
Osteoporosis (self-reported)	0.2	0.3	1.3	0.6	0.3	0.4	0.1	1.2	0.2	-0.4	-0.1	0.2	0.3	0.8
Osteoarthritis (self-reported)	0.3	0.3	0.9	-0.8	-0.4	-0.4	0.8	-1.0	-0.1	0.6	-0.8	0.1	-0.0	-0.0
Medication: Aspirin	1.7	2.3	6.9	1.9	2.6	2.2	-0.1	0.8	2.1	0.6	1.4	1.5	-0.1	0.4
Medication: Gliclazide	0.3	0.4	1.2	-0.0	0.9	1.1	-0.2	0.6	0.3	-0.7	0.6	-0.6	0.2	-0.5
Illnesses of father: None of the above (group 1)	1.0	1.2	4.3	-0.8	-0.6	-0.8	-0.1	0.7	-1.6	0.3	1.5	-1.1	1.0	-2.1
Smoking status: Current	0.3	0.4	1.9	1.4	-0.6	-0.5	-0.3	0.6	-0.3	-0.5	-0.2	-0.4	0.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.3	-0.9	-1.5	-1.5	0.4	1.3	-1.1	0.3	0.4	-1.0	1.4	-0.3
Whole body water mass	0.4	2.0	4.2	0.6	-1.2	-1.2	1.7	0.5	-2.0	-2.0	1.6	-1.1	-1.2	-1.5
Leg predicted mass (right)	0.2	0.8	2.4	0.5	-0.5	-0.5	1.6	0.2	-1.1	-1.2	1.1	-0.7	-1.0	-0.7
Arm fat mass (left)	0.5	2.0	7.3	-1.7	-1.5	-1.7	1.2	-0.4	-1.0	-1.6	-0.7	-1.1	-2.7	-0.3
Number of self-reported non-cancer illnesses	0.1	0.2	1.0	-0.3	-0.5	-0.2	1.0	0.4	-0.1	-0.8	0.2	0.1	-0.1	-0.1
Average weekly champagne plus white wine intake	2.5	3.4	19.2	1.1	0.0	0.0	4.4	2.4	-0.2	0.5	2.5	1.6	-0.9	-1.1
Miserableness	0.7	1.2	4.0	-0.8	-0.6	-0.5	-0.1	-1.2	-0.4	-1.7	-1.0	-2.0	-1.5	-0.3
Guilty feelings	0.3	0.5	1.4	-0.8	0.3	0.1	0.2	0.1	0.3	-0.9	0.3	-1.2	-0.9	-1.0
Wears glasses or contact lenses	0.5	0.6	2.5	0.3	-0.7	-0.9	-0.1	-0.2	-0.2	-1.4	1.6	0.4	-0.9	-0.2
Ever taken oral contraceptive pill	1.1	1.2	4.7	-0.4	1.2	1.2	-0.2	1.2	1.0	-2.2	1.1	-0.7	1.0	-0.8
Hearing aid user	1.4	1.6	4.6	-0.8	-1.0	-0.9	-1.5	0.2	-1.1	-2.1	-1.3	-2.1	-0.6	-0.9
Mother’s age at death	0.3	0.3	2.2	-0.5	-0.3	-0.4	1.5	0.5	-0.1	0.6	-0.1	0.4	-0.4	0.3
Financial situation satisfaction	0.3	0.4	1.9	-0.3	-0.0	0.2	0.3	0.1	-0.5	0.8	-0.0	-1.4	0.1	-1.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.2	0.1	-1.2	-1.3	-0.6	-1.5	-0.9	-0.1	-0.9	-0.6	-0.1	-0.1
Commuting to job workplace: Public transport	0.8	1.0	5.8	0.7	0.3	0.4	-0.1	-2.4	-0.2	0.3	-1.7	-0.3	0.7	-0.6
Eye problems/disorders: Glaucoma	0.6	0.7	1.7	1.2	0.8	1.0	0.8	0.2	0.7	-1.3	0.3	0.4	0.4	1.0
Medication: Blood pressure	0.4	0.7	2.4	1.6	-0.6	-0.8	1.3	0.3	-1.2	0.5	-0.5	0.3	-0.3	-0.0
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.1	0.5	-1.1	-0.6	-0.3	-1.5	-1.4	-0.9	0.4	-0.1	0.9	-1.1
Supplements: Fish oil (including cod liver oil)	0.9	1.1	6.1	-2.5	0.4	0.7	0.1	0.4	0.6	-0.2	-0.8	-1.2	-1.8	0.3
High cholesterol (Self-reported)	0.4	0.7	2.6	1.1	-0.3	-0.5	1.6	1.0	-0.0	-0.5	0.7	1.0	-0.9	-0.1
Medication: Bendroflumethiazide	1.0	1.5	3.9	-0.1	-1.5	-1.7	-0.2	-0.9	-2.0	0.3	-1.3	-0.8	-0.6	-1.8
Medication: Paracetamol	0.5	0.7	3.2	-0.7	-0.2	-0.4	-0.5	-1.0	0.3	-0.1	-1.6	0.2	1.8	0.3
Medication: Lisinopril	0.4	0.6	2.6	-0.1	-0.0	0.1	-0.7	-1.6	0.2	-1.0	-0.9	-0.7	0.4	0.8
Medication: Atorvastatin	1.0	1.3	4.1	0.7	0.1	-0.4	1.2	1.7	0.7	1.6	1.2	2.0	0.6	-0.5
Illnesses of father: High blood pressure	0.9	1.1	2.5	-0.2	1.4	1.6	-1.2	-0.2	1.4	0.9	-0.7	0.1	1.1	1.3
Alcohol drinker status: Never	1.1	1.3	3.4	0.2	0.7	0.9	-1.0	-0.9	1.2	0.6	-1.9	1.8	-1.2	0.9
Ever smoked	0.4	0.7	1.9	-0.2	-1.0	-0.9	0.4	-1.0	-0.9	-0.8	-0.7	-1.4	-0.7	-0.1
Basal metabolic rate	0.4	2.1	3.9	0.3	-1.4	-1.4	1.8	0.3	-2.0	-2.0	1.2	-1.0	-1.8	-1.4
Leg fat percentage (left)	0.7	2.5	7.7	-2.3	-1.9	-2.1	1.0	-0.6	-1.2	-1.4	-1.0	-0.7	-2.8	-0.6
Arm fat-free mass (left)	0.6	2.8	7.0	-0.4	-1.9	-1.8	1.7	0.2	-2.2	-2.6	0.9	-1.6	-2.1	-1.3
Number of operations (self-reported)	0.8	1.1	6.9	-2.6	0.5	0.6	0.8	-0.1	0.5	0.5	-1.5	-0.9	0.8	-0.3
Average weekly beer plus cider intake	0.6	0.9	3.3	0.3	1.2	0.8	-0.2	0.1	1.8	-0.4	0.1	1.0	0.8	1.6
Irritability	0.5	0.8	4.5	-1.4	-0.3	-0.2	0.5	-1.0	-0.3	-0.7	0.1	-2.1	0.1	-0.8
Risk taking	1.5	2.2	4.4	-2.1	-1.9	-1.6	-2.1	0.5	-0.9	-1.5	-1.1	-2.0	-0.1	0.7
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.3	-0.6	1.7	1.8	-0.5	-0.8	1.6	1.0	0.7	0.9	-0.7	-0.0
Fractured/broken bones in last 5 years	1.1	1.4	3.5	0.1	1.9	1.9	-0.8	-0.2	1.8	-0.2	-0.0	1.3	0.4	1.5
Age started oral contraceptive pill	0.6	0.8	4.9	2.2	0.6	0.1	-1.1	-0.0	0.0	0.8	0.4	0.5	0.9	-0.1
Diastolic blood pressure, automated reading	0.6	1.8	8.4	-2.9	-1.0	-0.7	0.1	-1.0	-0.8	-1.9	-0.9	-1.8	-1.1	-0.2
Ever depressed for a whole week	1.1	1.3	5.1	-0.8	0.5	0.8	-1.3	-1.6	-0.0	-1.6	-1.1	-2.2	-0.4	0.1
Unable to work because of sickness or disability	1.3	1.7	3.6	-1.7	-1.8	-1.7	-0.5	-1.0	-1.2	-1.6	-1.0	-1.9	-0.4	-0.5
Commuting to job workplace: Cycle	0.5	0.5	4.3	0.4	-0.3	-0.4	0.5	0.4	-0.7	-0.5	0.3	-0.1	-2.1	-0.4
Myopia	0.6	0.9	2.7	0.0	-1.4	-1.1	0.3	-0.3	-1.6	-0.4	0.5	-0.7	-1.7	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.2	0.4	-0.8	-0.7	-0.3	0.6	-0.7	-0.5	1.1	0.2	0.2	-0.4
Cholesterol lowering medication	0.4	0.6	1.4	1.2	-0.5	-1.1	0.5	0.6	-0.8	0.1	-0.1	1.2	-1.1	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.5	-1.2	1.0	0.9	0.5	1.1	1.0	0.3	0.3	0.6	-1.1	-0.4
Pain experienced in last month	0.3	0.4	2.5	0.3	0.6	0.1	-0.1	-0.0	0.2	-0.1	-0.3	-1.1	-1.6	-0.7
Supplements: Calcium	0.8	0.8	1.7	-1.3	0.6	0.8	-0.3	0.8	1.3	-1.0	-0.5	-0.6	-1.1	1.1
Basal cell carcinoma (self-reported)	1.3	1.6	6.8	-1.3	2.2	2.6	-0.1	0.1	1.4	0.0	0.2	-1.4	0.2	-0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	5.2	-1.0	0.7	0.6	-2.3	-0.6	0.7	-0.9	-0.3	-0.4	0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.1	0.3	1.4	1.3	1.1	-1.1	0.6	0.6	-0.1	0.8	0.7	0.3
Heart disease (siblings)	0.5	0.6	1.6	1.0	-0.7	-0.5	0.8	0.4	-0.8	0.8	0.8	0.8	1.2	-0.7
Alcohol drinker status: Previous	1.1	1.3	2.4	1.4	-1.4	-1.5	-1.1	-0.2	-1.1	-1.6	-0.7	-0.1	1.5	0.4
Pack years of smoking	0.4	0.6	1.3	-0.9	0.6	0.5	1.1	0.2	0.3	1.1	1.1	0.4	0.7	-0.6
Impedance of whole body	1.0	5.1	15.4	3.6	1.8	1.3	-0.3	-0.8	1.4	3.9	-0.5	3.6	2.0	1.4
Leg fat mass (left)	0.7	2.7	9.0	-2.2	-1.7	-1.8	1.5	-0.6	-1.3	-1.9	-0.7	-1.1	-3.0	-0.9
Arm predicted mass (left)	0.6	3.1	6.6	-0.2	-2.1	-2.0	1.6	0.3	-2.5	-2.6	1.1	-1.5	-1.9	-1.6