Hub : Genes

DLAT

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.129 0.0480 3.8e-06 0.092 NA 0.065 NA 0.083 2.0e-07 NA 1.3e-05 NA 8.0e-07
2 GTEx Muscle Skeletal 0.098 0.0375 2.8e-06 0.071 NA 0.045 NA 0.055 1.7e-07 NA 3.1e-05 NA 3.9e-06
3 GTEx Skin Sun Exposed Lower leg 0.046 0.0210 2.4e-03 0.032 NA 0.026 NA 0.031 1.0e-03 NA 2.7e-03 NA 1.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 3.2 5.1 5.8 2.3 2.1 -2.4
Bipolar Disorder or Schizophrenia 0.2 0.5 0.6 0.8 0.7 -0.7
Depressed Affect (Nagel 2018) 1.8 3.9 4.2 -1.9 -1.9 2.1
Depression (Nagel 2018) 1.5 2.2 2.7 -1.6 -1.4 1.4
Intelligence (Savage-Jansen 2018) 0.4 1.3 1.6 -0.9 -1.2 1.3
Neuroticism (Nagel 2018) 1.9 4.4 5.3 -2.3 -1.9 2.1
Schizophrenia (2018) 0.4 0.8 1.2 -0.7 -0.8 1.1
Schizophrenia vs Biploar Disorder 2.8 3.7 3.9 -1.9 -1.8 2.0
Worry (Nagel 2018) 1.6 3.3 3.7 -1.9 -1.7 1.8
Alzheimer’s Disease (in mother) 3.7 4.3 4.7 1.9 2.1 -2.2
Alzheimer’s Disease (in father) 0.5 0.6 1.0 0.3 0.9 -1.0
Alzheimer’s Disease (including proxy) 4.0 5.7 7.1 1.9 2.5 -2.7
Crohns Disease (2017) 0.4 0.8 0.9 -1.0 -0.9 0.9
Irritable Bowel Disease (IBD) 0.2 0.6 0.7 -0.7 -0.8 0.8
Ulcerative Colitis (UC) 0.0 0.1 0.1 -0.1 -0.3 0.3
Major Depression (MDD) 0.6 0.7 0.9 -0.7 -0.8 0.9
Reaction Time 1.4 2.7 2.9 1.7 1.6 -1.6
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.3 -0.1 -0.4 0.5
Breast Cancer 0.7 1.6 2.4 -0.5 -1.6 1.4
Ovarian Cancer 0.4 0.6 0.9 -0.5 -0.9 0.8
Prostate Cancer 0.0 0.0 0.0 0.2 -0.1 0.1
Age at First Birth 3.6 5.2 6.1 2.5 2.1 -2.3
Bipolar Disorder (2011) 0.3 0.3 0.6 0.8 0.3 -0.4
Body Mass Index (BMI) (2010) 0.4 0.5 0.7 -0.6 -0.8 0.6
Coronary Artery Disease (CAD) 2.9 3.4 3.9 2.0 1.7 -1.9
Crohns Disease (2012) 0.0 0.0 0.0 -0.2 -0.1 0.1
Mean Putamen Volume 0.6 0.7 0.8 -0.8 -0.9 0.9
Fasting Glucose 0.2 0.3 0.6 -0.7 0.5 0.2
HbA1C 0.0 0.0 0.0 0.0 0.1 0.2
HDL Cholesterol 4.0 6.7 7.1 -2.7 -2.5 2.6
LDL Cholesterol 0.0 0.0 0.0 0.1 -0.2 0.1
Lupus 0.1 0.1 0.2 0.5 0.1 -0.0
Neuroticism (2016) 1.7 2.4 2.9 -1.7 -1.5 1.4
Primary Biliary Cirrhosis 1.6 2.3 2.5 1.5 1.6 -1.6
Rheumatoid Arthritis 0.6 0.8 1.1 0.9 1.0 -0.8
Schizophrenia (2014) 0.1 0.2 0.3 -0.5 -0.2 0.6
Triglycerides 0.1 0.1 0.2 0.1 0.5 -0.4
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.3 0.6 0.3 -0.4
Ulcerative Colitis 0.3 0.4 0.5 0.7 0.4 -0.6
Blood Eosinophil Count 0.6 4.2 6.6 2.6 1.8 -1.7
Blood Platelet Count 0.3 3.8 4.8 -2.2 -1.5 2.1
Blood Red Count 1.4 13.7 17.2 3.0 3.9 -4.2
Blood White Count 0.5 3.4 4.5 1.4 2.1 -1.9
Heel T-Score 0.0 0.2 0.3 -0.2 -0.4 0.5
BMI 0.1 0.3 0.5 0.6 0.7 -0.4
Height 0.0 0.1 0.3 -0.5 0.1 -0.1
Waist Hip Ratio (WHR) 29.1 130.9 136.9 10.9 11.7 -11.7
Systolic Blood Pressure 1.1 5.6 6.6 2.6 1.9 -2.5
Smoking Status 0.9 2.2 2.3 -1.5 -1.4 1.5
Allergy or Eczema 2.8 7.3 8.0 -2.8 -2.5 2.8
Cardiovascular Disease 2.5 8.3 10.0 3.2 2.6 -2.9
Hypothyroidism (self reported) 1.1 2.6 3.1 -1.4 -1.7 1.8
Respiratory disease 2.8 6.3 7.3 -2.5 -2.3 2.7
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.7 -0.5 -0.8 0.4
Lung FEV1/FVC ratio 0.2 0.9 1.1 -0.8 -1.0 1.1
Lung FVC 0.1 0.5 0.5 0.7 0.7 -0.7
Neuroticism 2.0 4.8 5.2 -2.3 -2.0 2.2
Chronotype (morning person) 0.1 0.2 0.3 0.5 0.2 -0.4
Hair Pigment 0.0 1.1 1.9 -0.5 -1.4 1.0
Tanning 0.2 2.7 3.7 1.2 1.9 -1.7
Hand grip strength (left) 0.1 0.3 0.4 0.4 0.6 -0.5
Number of treatments/medications taken 0.0 0.1 0.2 0.4 0.0 -0.3
Average weekly spirits intake 0.2 0.3 0.4 -0.3 -0.7 0.6
Sensitivity / hurt feelings 2.2 3.7 5.4 -2.3 -1.5 1.9
Frequency of depressed mood in last 2 weeks 0.9 1.2 1.3 -1.1 -1.2 1.0
Hearing difficulty/problems: Yes 0.1 0.1 0.2 -0.4 0.1 0.2
Relative age of first facial hair 1.7 3.6 3.8 1.8 1.9 -1.9
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 0.8 0.8 0.7 -0.9
Ever used hormone-replacement therapy (HRT) 2.6 3.3 3.7 -1.8 -1.7 1.9
Ever had hysterectomy (womb removed) 1.9 2.1 2.2 -1.5 -1.4 1.4
Systolic blood pressure, automated reading 1.1 3.2 4.1 2.0 1.5 -1.8
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 0.2 -0.2 0.2
Angina 1.0 1.3 1.4 1.2 1.2 -1.0
Medication for hormone replacement therapy 0.8 0.9 1.3 -1.2 -0.7 1.0
Vitamin and mineral supplements 0.9 1.2 1.8 -1.0 -1.3 0.9
Supplements: Zinc 0.1 0.1 0.2 -0.4 -0.4 0.4
Medication: Co-codamol 2.2 2.5 3.6 -1.4 -1.4 1.9
Medication: Metformin 0.2 0.3 0.5 -0.2 -0.7 0.5
Diabetes (father) 0.6 0.7 1.0 -0.7 -0.8 1.0
Diabetes (mother) 0.1 0.1 0.1 0.2 0.4 -0.2
Severe depression (siblings) 0.9 1.0 1.1 0.9 1.1 -1.1
Pack years adult smoking proportion 0.6 0.9 1.2 0.9 1.1 -0.9
Impedance of leg (right) 0.1 0.5 0.8 0.4 0.7 -0.9
Leg fat-free mass (left) 0.1 0.6 0.8 -0.7 -0.6 0.9
Trunk fat percentage 0.0 0.1 0.2 -0.3 -0.2 0.4
Hand grip strength (right) 0.0 0.1 0.1 0.2 0.3 -0.3
Townsend deprivation index at recruitment 2.4 3.3 3.6 -1.8 -1.7 1.9
Current tobacco smoking 0.5 0.9 1.0 -0.9 -1.0 1.0
Average weekly fortified wine intake 0.1 0.1 0.1 -0.4 -0.2 0.2
Maternal smoking around birth 0.5 0.8 1.3 0.6 1.2 -0.7
Fed-up feelings 7.2 13.1 14.1 -3.8 -3.5 3.6
Frequency of unenthusiasm / disinterest in last 2 weeks 3.1 4.1 4.7 -2.2 -1.9 2.0
Relative age voice broke 0.1 0.2 0.3 0.4 0.3 -0.6
Taking other prescription medications 0.0 0.0 0.1 0.1 -0.3 0.2
Age when periods started (menarche) 0.2 0.4 0.4 0.6 0.6 -0.6
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 1.5 -1.0 -1.2 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.0 0.0 0.1 0.1 -0.1
Tinnitus: Yes, but not now, but have in the past 3.7 4.0 5.2 -1.5 -2.3 2.1
Qualifications: CSEs or equivalent 5.2 6.9 8.1 -2.8 -2.5 2.5
Serious illness, injury or assault to yourself 0.0 0.0 0.0 0.2 0.1 -0.0
High blood pressure 1.0 2.8 4.0 2.0 1.3 -1.7
Hayfever, allergic rhinitis or eczema 3.1 6.8 8.3 -2.9 -2.3 2.6
Multivitamins +/- minerals 0.1 0.1 0.2 0.1 0.4 -0.1
Stomach or abdominal pain in last month 0.1 0.1 0.2 -0.5 0.0 0.1
Supplements: Glucosamine 0.5 0.6 1.0 0.3 1.0 -0.9
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 0.1 0.4 -0.3
Medication: Atenolol 0.6 0.7 0.9 0.7 0.9 -0.9
Medication: Levothyroxine sodium 0.1 0.2 0.4 0.1 -0.5 0.7
Sitting height 0.5 3.4 4.2 -2.1 -1.7 1.7
Chronic bronchitis/emphysema (father) 0.5 0.6 1.1 0.5 1.0 -0.7
High blood pressure (mother) 0.3 0.5 0.5 -0.7 -0.7 0.7
Body mass index (BMI) 0.0 0.2 0.4 -0.3 -0.3 0.6
Impedance of leg (left) 0.3 1.5 2.1 0.9 1.2 -1.5
Leg predicted mass (left) 0.1 0.4 0.6 -0.6 -0.5 0.8
Trunk fat mass 0.0 0.0 0.0 -0.2 0.0 0.2
Waist circumference 3.1 11.4 12.5 3.2 3.5 -3.4
Number of incorrect matches in round 0.2 0.4 0.5 0.5 0.7 -0.6
Past tobacco smoking 0.0 0.0 0.1 0.3 -0.0 -0.2
Alcohol usually taken with meals 1.4 2.2 2.5 1.6 1.4 -1.5
Nervous feelings 2.1 3.9 4.3 -2.0 -1.9 2.1
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.7 4.2 -1.8 -1.9 2.1
Hearing difficulty/problems with background noise 0.0 0.1 0.1 -0.4 -0.1 0.2
Hair/balding pattern: Pattern 2 0.0 0.0 0.0 -0.1 0.2 -0.1
Had menopause 0.0 0.1 0.2 0.4 0.2 0.1
Had other major operations 0.7 0.8 0.9 -1.0 -0.9 0.8
Forced vital capacity (FVC) 0.1 0.4 0.7 -0.8 -0.5 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.0 0.0 -0.0 0.0 -0.2
Ever unenthusiastic/disinterested for a whole week 2.0 2.4 2.6 -1.5 -1.6 1.5
Qualifications: None of the above 0.2 0.5 0.6 -0.7 -0.7 0.8
Financial difficulties in last 2 years 1.8 2.4 4.0 -2.0 -1.2 1.3
Mouth/teeth dental problems 4.8 7.4 8.1 2.8 2.5 -2.8
Heart attack 0.0 0.0 0.0 0.1 0.0 0.0
Allergy 5.9 13.5 14.9 3.9 3.4 -3.8
Pain all over the body in last month 0.0 0.0 0.0 0.0 0.0 0.2
Diabetes (self-reported) 0.5 0.7 1.1 -0.7 -1.1 0.8
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.1 -0.2 -0.3 0.3
Medication: Ramipril 1.2 1.6 2.4 1.5 0.9 -1.2
Medication: Simvastatin 5.5 8.1 8.8 2.9 2.7 -3.0
Fluid intelligence score 0.5 1.1 1.4 1.2 0.9 -1.1
Illnesses of siblings 0.2 0.3 0.4 0.6 0.5 -0.5
Neuroticism score 3.1 6.5 7.5 -2.7 -2.3 2.5
Weight 0.0 0.0 0.0 -0.0 0.2 0.1
Impedance of arm (right) 0.1 0.3 0.5 -0.7 -0.6 0.2
Arm fat percentage (right) 0.1 0.3 0.4 -0.5 -0.5 0.6
Trunk fat-free mass 0.0 0.0 0.1 0.1 0.3 -0.0
Hip circumference 0.9 4.0 4.2 -2.0 -1.9 2.1
Time employed in main current job 0.0 0.0 0.0 0.2 0.1 0.1
Alcohol intake versus 10 years previously 1.3 2.0 2.3 -1.3 -1.5 1.4
Father’s age at death 1.3 1.7 2.2 -1.2 -1.5 1.3
Worrier / anxious feelings 1.7 3.3 3.5 -1.9 -1.7 1.9
Frequency of tiredness / lethargy in last 2 weeks 3.3 5.4 5.7 -2.4 -2.3 2.3
Falls in the last year 0.0 0.1 0.1 0.0 -0.4 0.2
Hair/balding pattern: Pattern 3 0.3 0.4 0.6 0.7 0.5 -0.7
Number of live births 3.2 4.5 5.2 -1.9 -2.2 2.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.3 -0.6 -0.5 0.3
Pulse rate 0.4 0.7 1.0 -1.0 -0.6 0.8
Happiness 0.1 0.1 0.1 0.2 0.3 -0.2
Noisy workplace 0.1 0.2 0.3 0.3 0.5 -0.4
Qualifications: A levels/AS levels or equivalent 0.4 1.0 1.3 0.8 1.0 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.3 1.1 0.7 -0.9
Mouth/teeth dental problems: Dentures 0.9 1.5 2.2 -1.5 -1.0 1.1
Asthma 6.5 12.7 15.0 -3.9 -3.3 3.5
Medication: Ibuprofen (e.g. Nurofen) 3.3 4.2 4.4 -2.0 -2.1 2.1
Medication: Cholesterol lowering 2.8 4.4 5.2 2.0 2.0 -2.3
Depression (self-reported) 0.0 0.0 0.0 -0.2 0.0 -0.2
Medication: Lansoprazole 0.0 0.0 0.0 0.0 0.0 0.1
Prospective memory result 1.4 1.7 1.9 -1.2 -1.3 1.4
Lung cancer (father) 1.2 1.4 1.8 1.1 1.4 -1.1
Illnesses of mother 2.0 2.4 2.6 1.6 1.6 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 0.9 -0.9 -0.9 0.7
Pulse wave Arterial Stiffness index 0.4 0.5 0.6 0.6 0.8 -0.7
Impedance of arm (left) 0.3 1.4 1.7 -1.3 -1.3 0.9
Arm fat mass (right) 0.0 0.1 0.2 -0.3 -0.3 0.4
Trunk predicted mass 0.0 0.0 0.1 0.1 0.3 -0.1
Standing height 0.0 0.2 0.2 0.1 0.5 -0.5
Length of working week for main job 0.8 0.8 1.2 0.9 1.1 -0.7
Exposure to tobacco smoke at home 2.8 3.2 4.2 -1.8 -1.5 2.0
Breastfed as a baby 1.6 2.0 2.2 1.4 1.5 -1.4
Tense / ‘highly strung’ 0.2 0.3 0.6 -0.5 -0.4 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 2.2 -1.5 -1.1 1.3
Hair/balding pattern: Pattern 4 0.3 0.7 0.8 0.9 0.8 -0.9
Birth weight of first child 2.6 4.7 6.0 -2.4 -2.0 2.0
Peak expiratory flow (PEF) 0.1 0.2 0.4 -0.2 -0.7 0.2
Pulse wave reflection index 0.7 0.8 1.1 0.9 0.8 -1.0
Ever highly irritable/argumentative for 2 days 2.5 2.9 3.9 -1.4 -1.7 2.0
Loud music exposure frequency 5.0 5.4 6.6 2.2 2.6 -2.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.3 -1.1 -0.5 0.5
Mouth/teeth dental problems: Bleeding gums 1.9 2.4 2.8 -1.4 -1.6 1.7
Blood clot in the leg (DVT) 0.5 0.7 0.9 -0.7 -0.7 1.0
Medication: Paracetamol 1.8 3.0 3.2 -1.8 -1.6 1.8
Headache pain in last month 1.4 2.5 2.7 -1.6 -1.6 1.5
Medication for cholesterol, blood pressure or diabetes 6.9 11.5 12.5 -3.4 -3.2 3.5
Glaucoma (self-reported) 0.1 0.1 0.1 0.3 0.1 -0.3
Gout (self-reported) 0.0 0.0 0.1 -0.3 0.2 -0.1
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 2.7 -1.1 -1.6 1.6
Medication: Amlodipine 0.3 0.5 0.9 0.9 0.6 -0.5
Medication: Ventolin 100micrograms inhaler 4.5 5.7 6.1 -2.4 -2.5 2.3
Birth weight 3.7 8.1 9.8 -3.1 -2.4 2.9
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.7 -1.3 -0.6 0.9
High blood pressure (siblings) 0.0 0.0 0.0 -0.1 -0.1 -0.1
Forced vital capacity (FVC), Best measure 0.2 0.7 1.1 -1.1 -0.7 0.7
Body fat percentage 0.0 0.1 0.1 -0.2 -0.1 0.3
Leg fat percentage (right) 0.0 0.0 0.0 -0.0 0.2 0.0
Arm fat-free mass (right) 0.1 0.3 0.4 0.6 0.7 -0.4
Exposure to tobacco smoke outside home 0.2 0.2 0.4 -0.6 -0.4 0.4
Comparative body size at age 10 0.0 0.1 0.1 0.3 -0.0 -0.2
Number of full brothers 2.5 3.2 3.5 -1.8 -1.6 1.9
Worry too long after embarrassment 0.5 0.9 1.7 -1.3 -0.8 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.1 -0.3 0.1 -0.2
Wheeze or whistling in the chest in last year 5.2 9.3 10.7 -3.3 -2.7 3.1
Number of children fathered 1.1 1.2 2.2 0.9 1.5 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 0.3 0.1 -0.1
Age at first live birth 3.9 6.9 7.8 2.8 2.4 -2.7
Pulse wave peak to peak time 0.5 0.6 0.9 -0.7 -0.9 0.8
Health satisfaction 0.0 0.0 0.0 0.2 0.0 0.0
Shortness of breath walking on level ground 8.5 10.2 11.7 -3.0 -3.1 3.4
Qualifications: College or University degree 2.8 8.9 10.7 3.3 2.6 -3.1
Eye problems/disorders: None of the above 0.7 0.8 1.2 -1.1 -0.8 0.9
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.8 -1.4 -0.7 0.8
Emphysema/chronic bronchitis 0.4 0.5 0.7 -0.5 -0.8 0.7
Medication for pain relief, constipation, heartburn 0.4 0.6 0.9 0.7 0.8 -1.0
Neck or shoulder pain in last month 0.4 0.5 0.7 -0.7 -0.6 0.8
Medication: Blood pressure 3.3 5.8 6.7 2.6 2.2 -2.4
Angina (self-reported) 0.5 0.6 0.8 0.9 0.8 -0.7
Migraine (self-reported) 0.1 0.1 0.1 0.2 0.3 -0.3
Medication: Ibuprofen 3.0 3.6 3.8 -1.9 -1.9 1.8
Medication: Allopurinol 0.0 0.0 0.0 -0.1 -0.1 0.1
Medication: Omeprazole 2.1 2.5 3.3 1.5 1.8 -1.4
Medication: Seretide 50 evohaler 5.4 6.2 6.8 -2.3 -2.6 2.5
Mean time to correctly identify matches 1.3 2.5 3.7 1.9 1.3 -1.4
Heart disease (mother) 1.2 1.4 2.1 -1.0 -1.4 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 1.9 -1.1 -1.4 1.2
Whole body fat mass 0.0 0.1 0.2 -0.3 -0.2 0.5
Leg fat mass (right) 0.0 0.0 0.1 0.1 0.3 0.0
Arm predicted mass (right) 0.0 0.0 0.1 0.1 0.3 0.1
Pulse rate, automated reading 0.0 0.1 0.1 -0.4 0.2 0.2
Alcohol intake frequency. 1.0 2.4 2.8 -1.4 -1.7 1.6
Comparative height size at age 10 0.0 0.0 0.0 -0.2 0.2 -0.0
Number of full sisters 1.9 2.3 2.5 -1.6 -1.6 1.4
Suffer from ‘nerves’ 8.5 13.4 14.8 -3.9 -3.5 3.6
Overall health rating 1.1 2.3 2.5 -1.5 -1.5 1.6
Chest pain or discomfort 2.1 3.1 3.4 -1.9 -1.6 1.8
Had major operations 0.9 1.1 1.6 0.6 1.3 -1.1
Age at last live birth 0.4 0.6 1.0 1.0 0.5 -0.6
Family relationship satisfaction 0.0 0.0 0.0 0.1 -0.2 0.1
Leg pain on walking 0.4 0.5 0.7 0.6 0.7 -0.8
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 2.0 -1.1 -1.4 1.4
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.1 -0.4 0.1 -0.3
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 2.3 1.5 1.3 -1.2
Medication: Aspirin 4.6 6.1 7.4 2.7 2.3 -2.4
Supplements: Vitamin C 0.2 0.2 0.4 0.1 0.6 -0.5
Knee pain experienced in last month 0.3 0.5 0.6 -0.7 -0.7 0.8
Hypertension (Self-reported) 1.3 3.7 5.2 2.3 1.5 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 0.7 -0.6 -0.7 0.9
Illnesses of father: Heart disease 7.1 9.9 10.7 3.3 3.0 -3.2
Illnesses of siblings: Diabetes 1.9 2.3 2.8 -1.7 -1.3 1.5
Smoking status: Previous 0.0 0.1 0.1 0.2 0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 -0.2 0.3 -0.2
Whole body fat-free mass 0.0 0.0 0.1 -0.1 0.0 0.2
Leg fat-free mass (right) 0.0 0.2 0.4 -0.5 -0.3 0.6
Arm fat percentage (left) 0.2 0.9 1.0 -0.9 -0.9 1.0
Average weekly red wine intake 0.8 1.2 2.0 1.4 0.9 -1.0
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.0 0.5 0.8 -1.0
Mood swings 0.2 0.4 0.6 -0.8 -0.4 0.7
Loneliness, isolation 0.7 1.0 1.0 -1.0 -0.9 1.0
Long-standing illness, disability or infirmity 0.7 1.0 1.2 -0.8 -1.1 1.1
Ever had bowel cancer screening 2.7 3.2 4.6 2.1 1.4 -1.8
Diabetes diagnosed by doctor 0.0 0.1 0.2 0.1 -0.5 0.1
Ever had stillbirth, spontaneous miscarriage or termination 4.0 4.3 4.9 1.8 2.2 -2.1
Friendships satisfaction 0.2 0.2 0.4 -0.1 -0.6 0.6
Qualifications: nursing, teaching 0.7 1.0 1.2 1.0 1.1 -0.9
Commuting to job workplace: Walk 0.1 0.1 0.3 0.5 0.0 -0.2
Eye problems/disorders: Cataract 2.7 3.2 3.3 1.8 1.8 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.1 -1.0 -1.0 1.1
Medication for cholesterol 0.6 0.9 1.1 -1.1 -0.8 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 1.4 0.9 1.2 -1.2
Back pain experienced in last month 1.2 1.7 2.2 -1.4 -1.1 1.5
Mineral and other dietary supplements 0.8 1.1 1.5 -0.8 -1.1 1.2
Breast cancer (self-reported) 2.3 2.8 3.4 1.6 1.8 -1.6
Asthma (self-reported) 6.6 13.2 14.8 -3.9 -3.4 3.6
Osteoporosis (self-reported) 0.1 0.2 0.4 0.6 0.2 -0.3
Osteoarthritis (self-reported) 2.2 2.9 3.8 -1.7 -1.4 1.9
Medication: Aspirin 5.2 6.8 8.4 2.9 2.4 -2.5
Medication: Gliclazide 0.3 0.4 0.7 0.9 0.3 -0.5
Illnesses of father: None of the above (group 1) 2.8 3.4 4.0 -1.9 -1.6 2.0
Smoking status: Current 0.7 1.1 1.1 -1.0 -1.0 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.0 1.0 1.0 -0.9
Whole body water mass 0.0 0.0 0.0 -0.1 0.1 0.2
Leg predicted mass (right) 0.0 0.2 0.4 -0.5 -0.3 0.6
Arm fat mass (left) 0.1 0.3 0.5 -0.6 -0.5 0.7
Number of self-reported non-cancer illnesses 0.0 0.0 0.1 0.2 0.1 -0.1
Average weekly champagne plus white wine intake 0.2 0.2 0.3 0.3 0.5 -0.5
Miserableness 5.2 8.9 9.7 -2.8 -3.1 3.1
Guilty feelings 0.9 1.3 1.7 -1.3 -0.9 1.2
Wears glasses or contact lenses 7.4 8.5 9.4 2.8 3.1 -2.9
Ever taken oral contraceptive pill 3.5 3.8 4.3 -2.1 -1.9 1.9
Hearing aid user 0.2 0.2 0.5 0.7 0.4 -0.3
Mother’s age at death 0.1 0.2 0.4 0.4 0.2 -0.6
Financial situation satisfaction 0.7 0.8 1.1 -0.8 -1.0 0.9
Tinnitus: Yes, now most or all of the time 0.7 0.9 1.0 0.9 1.0 -0.9
Commuting to job workplace: Public transport 0.1 0.1 0.3 0.6 0.2 0.1
Eye problems/disorders: Glaucoma 0.0 0.0 0.0 0.1 0.1 -0.2
Medication: Blood pressure 2.3 4.3 5.9 2.4 1.7 -2.0
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.3 -0.8 -0.6 1.1
Supplements: Fish oil (including cod liver oil) 0.5 0.7 0.8 -0.9 -0.9 0.7
High cholesterol (Self-reported) 3.8 6.7 7.6 2.8 2.3 -2.7
Medication: Bendroflumethiazide 0.1 0.1 0.2 0.2 -0.3 -0.4
Medication: Paracetamol 2.1 3.2 3.4 -1.7 -1.8 1.8
Medication: Lisinopril 3.0 3.8 4.0 2.0 1.9 -2.0
Medication: Atorvastatin 0.1 0.1 0.1 0.1 -0.3 0.4
Illnesses of father: High blood pressure 0.1 0.2 0.3 0.6 0.3 -0.2
Alcohol drinker status: Never 0.3 0.3 0.7 -0.8 -0.3 0.5
Ever smoked 0.6 1.0 1.2 -1.1 -0.8 1.1
Basal metabolic rate 0.0 0.0 0.0 -0.1 0.1 0.2
Leg fat percentage (left) 0.1 0.2 0.3 0.4 0.6 -0.3
Arm fat-free mass (left) 0.1 0.5 0.8 0.7 0.9 -0.6
Number of operations (self-reported) 0.4 0.5 0.8 0.3 0.9 -0.9
Average weekly beer plus cider intake 0.8 1.1 1.6 0.9 1.3 -0.9
Irritability 0.2 0.4 0.5 0.6 0.7 -0.5
Risk taking 3.2 4.7 5.2 1.9 2.2 -2.3
Ever had prostate specific antigen (PSA) test 3.4 3.9 4.5 2.1 1.8 -2.0
Fractured/broken bones in last 5 years 3.4 4.4 5.2 2.0 2.3 -1.9
Age started oral contraceptive pill 0.4 0.6 0.7 0.9 0.7 -0.7
Diastolic blood pressure, automated reading 0.0 0.1 0.3 0.5 0.0 -0.3
Ever depressed for a whole week 1.8 2.2 2.2 -1.5 -1.5 1.4
Unable to work because of sickness or disability 0.0 0.0 0.0 -0.2 0.1 -0.1
Commuting to job workplace: Cycle 1.9 2.3 2.4 1.5 1.5 -1.5
Myopia 3.1 4.5 5.3 2.3 1.9 -2.1
Vascular/heart problems diagnosed by doctor 1.7 4.7 5.9 -2.4 -1.9 2.2
Cholesterol lowering medication 3.4 5.0 5.7 2.4 2.1 -2.2
Medication: Omeprazole (e.g. Zanprol) 2.3 2.8 3.5 1.7 1.9 -1.4
Pain experienced in last month 1.5 2.5 3.5 1.4 1.4 -1.9
Supplements: Calcium 1.4 1.6 1.7 1.3 1.2 -1.3
Basal cell carcinoma (self-reported) 4.8 5.8 6.4 2.4 2.5 -2.2
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.0 0.0 0.1 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 0.8 -0.7 -0.7 0.9
Heart disease (siblings) 1.0 1.2 1.4 -1.0 -1.2 1.1
Alcohol drinker status: Previous 0.3 0.4 0.5 -0.5 -0.7 0.5
Pack years of smoking 0.9 1.4 1.7 1.2 1.3 -1.0
Impedance of whole body 0.0 0.1 0.2 -0.5 -0.4 0.1
Leg fat mass (left) 0.0 0.1 0.2 0.2 0.4 -0.1
Arm predicted mass (left) 0.0 0.2 0.4 0.4 0.6 -0.3