Hub : Genes

DLAT

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.129	0.0480	3.8e-06	0.092	NA	0.065	NA	0.083	2.0e-07	NA	1.3e-05	NA	8.0e-07
2	GTEx	Muscle Skeletal	0.098	0.0375	2.8e-06	0.071	NA	0.045	NA	0.055	1.7e-07	NA	3.1e-05	NA	3.9e-06
3	GTEx	Skin Sun Exposed Lower leg	0.046	0.0210	2.4e-03	0.032	NA	0.026	NA	0.031	1.0e-03	NA	2.7e-03	NA	1.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	3.2	5.1	5.8	2.3	2.1	-2.4
Bipolar Disorder or Schizophrenia	0.2	0.5	0.6	0.8	0.7	-0.7
Depressed Affect (Nagel 2018)	1.8	3.9	4.2	-1.9	-1.9	2.1
Depression (Nagel 2018)	1.5	2.2	2.7	-1.6	-1.4	1.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	1.6	-0.9	-1.2	1.3
Neuroticism (Nagel 2018)	1.9	4.4	5.3	-2.3	-1.9	2.1
Schizophrenia (2018)	0.4	0.8	1.2	-0.7	-0.8	1.1
Schizophrenia vs Biploar Disorder	2.8	3.7	3.9	-1.9	-1.8	2.0
Worry (Nagel 2018)	1.6	3.3	3.7	-1.9	-1.7	1.8
Alzheimer’s Disease (in mother)	3.7	4.3	4.7	1.9	2.1	-2.2
Alzheimer’s Disease (in father)	0.5	0.6	1.0	0.3	0.9	-1.0
Alzheimer’s Disease (including proxy)	4.0	5.7	7.1	1.9	2.5	-2.7
Crohns Disease (2017)	0.4	0.8	0.9	-1.0	-0.9	0.9
Irritable Bowel Disease (IBD)	0.2	0.6	0.7	-0.7	-0.8	0.8
Ulcerative Colitis (UC)	0.0	0.1	0.1	-0.1	-0.3	0.3
Major Depression (MDD)	0.6	0.7	0.9	-0.7	-0.8	0.9
Reaction Time	1.4	2.7	2.9	1.7	1.6	-1.6
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	-0.1	-0.4	0.5
Breast Cancer	0.7	1.6	2.4	-0.5	-1.6	1.4
Ovarian Cancer	0.4	0.6	0.9	-0.5	-0.9	0.8
Prostate Cancer	0.0	0.0	0.0	0.2	-0.1	0.1
Age at First Birth	3.6	5.2	6.1	2.5	2.1	-2.3
Bipolar Disorder (2011)	0.3	0.3	0.6	0.8	0.3	-0.4
Body Mass Index (BMI) (2010)	0.4	0.5	0.7	-0.6	-0.8	0.6
Coronary Artery Disease (CAD)	2.9	3.4	3.9	2.0	1.7	-1.9
Crohns Disease (2012)	0.0	0.0	0.0	-0.2	-0.1	0.1
Mean Putamen Volume	0.6	0.7	0.8	-0.8	-0.9	0.9
Fasting Glucose	0.2	0.3	0.6	-0.7	0.5	0.2
HbA1C	0.0	0.0	0.0	0.0	0.1	0.2
HDL Cholesterol	4.0	6.7	7.1	-2.7	-2.5	2.6
LDL Cholesterol	0.0	0.0	0.0	0.1	-0.2	0.1
Lupus	0.1	0.1	0.2	0.5	0.1	-0.0
Neuroticism (2016)	1.7	2.4	2.9	-1.7	-1.5	1.4
Primary Biliary Cirrhosis	1.6	2.3	2.5	1.5	1.6	-1.6
Rheumatoid Arthritis	0.6	0.8	1.1	0.9	1.0	-0.8
Schizophrenia (2014)	0.1	0.2	0.3	-0.5	-0.2	0.6
Triglycerides	0.1	0.1	0.2	0.1	0.5	-0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.6	0.3	-0.4
Ulcerative Colitis	0.3	0.4	0.5	0.7	0.4	-0.6
Blood Eosinophil Count	0.6	4.2	6.6	2.6	1.8	-1.7
Blood Platelet Count	0.3	3.8	4.8	-2.2	-1.5	2.1
Blood Red Count	1.4	13.7	17.2	3.0	3.9	-4.2
Blood White Count	0.5	3.4	4.5	1.4	2.1	-1.9
Heel T-Score	0.0	0.2	0.3	-0.2	-0.4	0.5
BMI	0.1	0.3	0.5	0.6	0.7	-0.4
Height	0.0	0.1	0.3	-0.5	0.1	-0.1
Waist Hip Ratio (WHR)	29.1	130.9	136.9	10.9	11.7	-11.7
Systolic Blood Pressure	1.1	5.6	6.6	2.6	1.9	-2.5
Smoking Status	0.9	2.2	2.3	-1.5	-1.4	1.5
Allergy or Eczema	2.8	7.3	8.0	-2.8	-2.5	2.8
Cardiovascular Disease	2.5	8.3	10.0	3.2	2.6	-2.9
Hypothyroidism (self reported)	1.1	2.6	3.1	-1.4	-1.7	1.8
Respiratory disease	2.8	6.3	7.3	-2.5	-2.3	2.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.5	-0.8	0.4
Lung FEV1/FVC ratio	0.2	0.9	1.1	-0.8	-1.0	1.1
Lung FVC	0.1	0.5	0.5	0.7	0.7	-0.7
Neuroticism	2.0	4.8	5.2	-2.3	-2.0	2.2
Chronotype (morning person)	0.1	0.2	0.3	0.5	0.2	-0.4
Hair Pigment	0.0	1.1	1.9	-0.5	-1.4	1.0
Tanning	0.2	2.7	3.7	1.2	1.9	-1.7
Hand grip strength (left)	0.1	0.3	0.4	0.4	0.6	-0.5
Number of treatments/medications taken	0.0	0.1	0.2	0.4	0.0	-0.3
Average weekly spirits intake	0.2	0.3	0.4	-0.3	-0.7	0.6
Sensitivity / hurt feelings	2.2	3.7	5.4	-2.3	-1.5	1.9
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.3	-1.1	-1.2	1.0
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.4	0.1	0.2
Relative age of first facial hair	1.7	3.6	3.8	1.8	1.9	-1.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	0.8	0.8	0.7	-0.9
Ever used hormone-replacement therapy (HRT)	2.6	3.3	3.7	-1.8	-1.7	1.9
Ever had hysterectomy (womb removed)	1.9	2.1	2.2	-1.5	-1.4	1.4
Systolic blood pressure, automated reading	1.1	3.2	4.1	2.0	1.5	-1.8
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.2	-0.2	0.2
Angina	1.0	1.3	1.4	1.2	1.2	-1.0
Medication for hormone replacement therapy	0.8	0.9	1.3	-1.2	-0.7	1.0
Vitamin and mineral supplements	0.9	1.2	1.8	-1.0	-1.3	0.9
Supplements: Zinc	0.1	0.1	0.2	-0.4	-0.4	0.4
Medication: Co-codamol	2.2	2.5	3.6	-1.4	-1.4	1.9
Medication: Metformin	0.2	0.3	0.5	-0.2	-0.7	0.5
Diabetes (father)	0.6	0.7	1.0	-0.7	-0.8	1.0
Diabetes (mother)	0.1	0.1	0.1	0.2	0.4	-0.2
Severe depression (siblings)	0.9	1.0	1.1	0.9	1.1	-1.1
Pack years adult smoking proportion	0.6	0.9	1.2	0.9	1.1	-0.9
Impedance of leg (right)	0.1	0.5	0.8	0.4	0.7	-0.9
Leg fat-free mass (left)	0.1	0.6	0.8	-0.7	-0.6	0.9
Trunk fat percentage	0.0	0.1	0.2	-0.3	-0.2	0.4
Hand grip strength (right)	0.0	0.1	0.1	0.2	0.3	-0.3
Townsend deprivation index at recruitment	2.4	3.3	3.6	-1.8	-1.7	1.9
Current tobacco smoking	0.5	0.9	1.0	-0.9	-1.0	1.0
Average weekly fortified wine intake	0.1	0.1	0.1	-0.4	-0.2	0.2
Maternal smoking around birth	0.5	0.8	1.3	0.6	1.2	-0.7
Fed-up feelings	7.2	13.1	14.1	-3.8	-3.5	3.6
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	4.7	-2.2	-1.9	2.0
Relative age voice broke	0.1	0.2	0.3	0.4	0.3	-0.6
Taking other prescription medications	0.0	0.0	0.1	0.1	-0.3	0.2
Age when periods started (menarche)	0.2	0.4	0.4	0.6	0.6	-0.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	1.5	-1.0	-1.2	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	0.1	0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	3.7	4.0	5.2	-1.5	-2.3	2.1
Qualifications: CSEs or equivalent	5.2	6.9	8.1	-2.8	-2.5	2.5
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.2	0.1	-0.0
High blood pressure	1.0	2.8	4.0	2.0	1.3	-1.7
Hayfever, allergic rhinitis or eczema	3.1	6.8	8.3	-2.9	-2.3	2.6
Multivitamins +/- minerals	0.1	0.1	0.2	0.1	0.4	-0.1
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.5	0.0	0.1
Supplements: Glucosamine	0.5	0.6	1.0	0.3	1.0	-0.9
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.1	0.4	-0.3
Medication: Atenolol	0.6	0.7	0.9	0.7	0.9	-0.9
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.1	-0.5	0.7
Sitting height	0.5	3.4	4.2	-2.1	-1.7	1.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	0.5	1.0	-0.7
High blood pressure (mother)	0.3	0.5	0.5	-0.7	-0.7	0.7
Body mass index (BMI)	0.0	0.2	0.4	-0.3	-0.3	0.6
Impedance of leg (left)	0.3	1.5	2.1	0.9	1.2	-1.5
Leg predicted mass (left)	0.1	0.4	0.6	-0.6	-0.5	0.8
Trunk fat mass	0.0	0.0	0.0	-0.2	0.0	0.2
Waist circumference	3.1	11.4	12.5	3.2	3.5	-3.4
Number of incorrect matches in round	0.2	0.4	0.5	0.5	0.7	-0.6
Past tobacco smoking	0.0	0.0	0.1	0.3	-0.0	-0.2
Alcohol usually taken with meals	1.4	2.2	2.5	1.6	1.4	-1.5
Nervous feelings	2.1	3.9	4.3	-2.0	-1.9	2.1
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.7	4.2	-1.8	-1.9	2.1
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.4	-0.1	0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.1	0.2	-0.1
Had menopause	0.0	0.1	0.2	0.4	0.2	0.1
Had other major operations	0.7	0.8	0.9	-1.0	-0.9	0.8
Forced vital capacity (FVC)	0.1	0.4	0.7	-0.8	-0.5	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.0	0.0	-0.2
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	2.6	-1.5	-1.6	1.5
Qualifications: None of the above	0.2	0.5	0.6	-0.7	-0.7	0.8
Financial difficulties in last 2 years	1.8	2.4	4.0	-2.0	-1.2	1.3
Mouth/teeth dental problems	4.8	7.4	8.1	2.8	2.5	-2.8
Heart attack	0.0	0.0	0.0	0.1	0.0	0.0
Allergy	5.9	13.5	14.9	3.9	3.4	-3.8
Pain all over the body in last month	0.0	0.0	0.0	0.0	0.0	0.2
Diabetes (self-reported)	0.5	0.7	1.1	-0.7	-1.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	-0.2	-0.3	0.3
Medication: Ramipril	1.2	1.6	2.4	1.5	0.9	-1.2
Medication: Simvastatin	5.5	8.1	8.8	2.9	2.7	-3.0
Fluid intelligence score	0.5	1.1	1.4	1.2	0.9	-1.1
Illnesses of siblings	0.2	0.3	0.4	0.6	0.5	-0.5
Neuroticism score	3.1	6.5	7.5	-2.7	-2.3	2.5
Weight	0.0	0.0	0.0	-0.0	0.2	0.1
Impedance of arm (right)	0.1	0.3	0.5	-0.7	-0.6	0.2
Arm fat percentage (right)	0.1	0.3	0.4	-0.5	-0.5	0.6
Trunk fat-free mass	0.0	0.0	0.1	0.1	0.3	-0.0
Hip circumference	0.9	4.0	4.2	-2.0	-1.9	2.1
Time employed in main current job	0.0	0.0	0.0	0.2	0.1	0.1
Alcohol intake versus 10 years previously	1.3	2.0	2.3	-1.3	-1.5	1.4
Father’s age at death	1.3	1.7	2.2	-1.2	-1.5	1.3
Worrier / anxious feelings	1.7	3.3	3.5	-1.9	-1.7	1.9
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.4	5.7	-2.4	-2.3	2.3
Falls in the last year	0.0	0.1	0.1	0.0	-0.4	0.2
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	0.7	0.5	-0.7
Number of live births	3.2	4.5	5.2	-1.9	-2.2	2.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.3	-0.6	-0.5	0.3
Pulse rate	0.4	0.7	1.0	-1.0	-0.6	0.8
Happiness	0.1	0.1	0.1	0.2	0.3	-0.2
Noisy workplace	0.1	0.2	0.3	0.3	0.5	-0.4
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.3	0.8	1.0	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.3	1.1	0.7	-0.9
Mouth/teeth dental problems: Dentures	0.9	1.5	2.2	-1.5	-1.0	1.1
Asthma	6.5	12.7	15.0	-3.9	-3.3	3.5
Medication: Ibuprofen (e.g. Nurofen)	3.3	4.2	4.4	-2.0	-2.1	2.1
Medication: Cholesterol lowering	2.8	4.4	5.2	2.0	2.0	-2.3
Depression (self-reported)	0.0	0.0	0.0	-0.2	0.0	-0.2
Medication: Lansoprazole	0.0	0.0	0.0	0.0	0.0	0.1
Prospective memory result	1.4	1.7	1.9	-1.2	-1.3	1.4
Lung cancer (father)	1.2	1.4	1.8	1.1	1.4	-1.1
Illnesses of mother	2.0	2.4	2.6	1.6	1.6	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.9	-0.9	-0.9	0.7
Pulse wave Arterial Stiffness index	0.4	0.5	0.6	0.6	0.8	-0.7
Impedance of arm (left)	0.3	1.4	1.7	-1.3	-1.3	0.9
Arm fat mass (right)	0.0	0.1	0.2	-0.3	-0.3	0.4
Trunk predicted mass	0.0	0.0	0.1	0.1	0.3	-0.1
Standing height	0.0	0.2	0.2	0.1	0.5	-0.5
Length of working week for main job	0.8	0.8	1.2	0.9	1.1	-0.7
Exposure to tobacco smoke at home	2.8	3.2	4.2	-1.8	-1.5	2.0
Breastfed as a baby	1.6	2.0	2.2	1.4	1.5	-1.4
Tense / ‘highly strung’	0.2	0.3	0.6	-0.5	-0.4	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.2	-1.5	-1.1	1.3
Hair/balding pattern: Pattern 4	0.3	0.7	0.8	0.9	0.8	-0.9
Birth weight of first child	2.6	4.7	6.0	-2.4	-2.0	2.0
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.2	-0.7	0.2
Pulse wave reflection index	0.7	0.8	1.1	0.9	0.8	-1.0
Ever highly irritable/argumentative for 2 days	2.5	2.9	3.9	-1.4	-1.7	2.0
Loud music exposure frequency	5.0	5.4	6.6	2.2	2.6	-2.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	-1.1	-0.5	0.5
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	2.8	-1.4	-1.6	1.7
Blood clot in the leg (DVT)	0.5	0.7	0.9	-0.7	-0.7	1.0
Medication: Paracetamol	1.8	3.0	3.2	-1.8	-1.6	1.8
Headache pain in last month	1.4	2.5	2.7	-1.6	-1.6	1.5
Medication for cholesterol, blood pressure or diabetes	6.9	11.5	12.5	-3.4	-3.2	3.5
Glaucoma (self-reported)	0.1	0.1	0.1	0.3	0.1	-0.3
Gout (self-reported)	0.0	0.0	0.1	-0.3	0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	2.7	-1.1	-1.6	1.6
Medication: Amlodipine	0.3	0.5	0.9	0.9	0.6	-0.5
Medication: Ventolin 100micrograms inhaler	4.5	5.7	6.1	-2.4	-2.5	2.3
Birth weight	3.7	8.1	9.8	-3.1	-2.4	2.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.7	-1.3	-0.6	0.9
High blood pressure (siblings)	0.0	0.0	0.0	-0.1	-0.1	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.7	1.1	-1.1	-0.7	0.7
Body fat percentage	0.0	0.1	0.1	-0.2	-0.1	0.3
Leg fat percentage (right)	0.0	0.0	0.0	-0.0	0.2	0.0
Arm fat-free mass (right)	0.1	0.3	0.4	0.6	0.7	-0.4
Exposure to tobacco smoke outside home	0.2	0.2	0.4	-0.6	-0.4	0.4
Comparative body size at age 10	0.0	0.1	0.1	0.3	-0.0	-0.2
Number of full brothers	2.5	3.2	3.5	-1.8	-1.6	1.9
Worry too long after embarrassment	0.5	0.9	1.7	-1.3	-0.8	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.3	0.1	-0.2
Wheeze or whistling in the chest in last year	5.2	9.3	10.7	-3.3	-2.7	3.1
Number of children fathered	1.1	1.2	2.2	0.9	1.5	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.3	0.1	-0.1
Age at first live birth	3.9	6.9	7.8	2.8	2.4	-2.7
Pulse wave peak to peak time	0.5	0.6	0.9	-0.7	-0.9	0.8
Health satisfaction	0.0	0.0	0.0	0.2	0.0	0.0
Shortness of breath walking on level ground	8.5	10.2	11.7	-3.0	-3.1	3.4
Qualifications: College or University degree	2.8	8.9	10.7	3.3	2.6	-3.1
Eye problems/disorders: None of the above	0.7	0.8	1.2	-1.1	-0.8	0.9
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.8	-1.4	-0.7	0.8
Emphysema/chronic bronchitis	0.4	0.5	0.7	-0.5	-0.8	0.7
Medication for pain relief, constipation, heartburn	0.4	0.6	0.9	0.7	0.8	-1.0
Neck or shoulder pain in last month	0.4	0.5	0.7	-0.7	-0.6	0.8
Medication: Blood pressure	3.3	5.8	6.7	2.6	2.2	-2.4
Angina (self-reported)	0.5	0.6	0.8	0.9	0.8	-0.7
Migraine (self-reported)	0.1	0.1	0.1	0.2	0.3	-0.3
Medication: Ibuprofen	3.0	3.6	3.8	-1.9	-1.9	1.8
Medication: Allopurinol	0.0	0.0	0.0	-0.1	-0.1	0.1
Medication: Omeprazole	2.1	2.5	3.3	1.5	1.8	-1.4
Medication: Seretide 50 evohaler	5.4	6.2	6.8	-2.3	-2.6	2.5
Mean time to correctly identify matches	1.3	2.5	3.7	1.9	1.3	-1.4
Heart disease (mother)	1.2	1.4	2.1	-1.0	-1.4	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	1.9	-1.1	-1.4	1.2
Whole body fat mass	0.0	0.1	0.2	-0.3	-0.2	0.5
Leg fat mass (right)	0.0	0.0	0.1	0.1	0.3	0.0
Arm predicted mass (right)	0.0	0.0	0.1	0.1	0.3	0.1
Pulse rate, automated reading	0.0	0.1	0.1	-0.4	0.2	0.2
Alcohol intake frequency.	1.0	2.4	2.8	-1.4	-1.7	1.6
Comparative height size at age 10	0.0	0.0	0.0	-0.2	0.2	-0.0
Number of full sisters	1.9	2.3	2.5	-1.6	-1.6	1.4
Suffer from ‘nerves’	8.5	13.4	14.8	-3.9	-3.5	3.6
Overall health rating	1.1	2.3	2.5	-1.5	-1.5	1.6
Chest pain or discomfort	2.1	3.1	3.4	-1.9	-1.6	1.8
Had major operations	0.9	1.1	1.6	0.6	1.3	-1.1
Age at last live birth	0.4	0.6	1.0	1.0	0.5	-0.6
Family relationship satisfaction	0.0	0.0	0.0	0.1	-0.2	0.1
Leg pain on walking	0.4	0.5	0.7	0.6	0.7	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	2.0	-1.1	-1.4	1.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.4	0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	2.3	1.5	1.3	-1.2
Medication: Aspirin	4.6	6.1	7.4	2.7	2.3	-2.4
Supplements: Vitamin C	0.2	0.2	0.4	0.1	0.6	-0.5
Knee pain experienced in last month	0.3	0.5	0.6	-0.7	-0.7	0.8
Hypertension (Self-reported)	1.3	3.7	5.2	2.3	1.5	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.7	-0.6	-0.7	0.9
Illnesses of father: Heart disease	7.1	9.9	10.7	3.3	3.0	-3.2
Illnesses of siblings: Diabetes	1.9	2.3	2.8	-1.7	-1.3	1.5
Smoking status: Previous	0.0	0.1	0.1	0.2	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	-0.2	0.3	-0.2
Whole body fat-free mass	0.0	0.0	0.1	-0.1	0.0	0.2
Leg fat-free mass (right)	0.0	0.2	0.4	-0.5	-0.3	0.6
Arm fat percentage (left)	0.2	0.9	1.0	-0.9	-0.9	1.0
Average weekly red wine intake	0.8	1.2	2.0	1.4	0.9	-1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	0.5	0.8	-1.0
Mood swings	0.2	0.4	0.6	-0.8	-0.4	0.7
Loneliness, isolation	0.7	1.0	1.0	-1.0	-0.9	1.0
Long-standing illness, disability or infirmity	0.7	1.0	1.2	-0.8	-1.1	1.1
Ever had bowel cancer screening	2.7	3.2	4.6	2.1	1.4	-1.8
Diabetes diagnosed by doctor	0.0	0.1	0.2	0.1	-0.5	0.1
Ever had stillbirth, spontaneous miscarriage or termination	4.0	4.3	4.9	1.8	2.2	-2.1
Friendships satisfaction	0.2	0.2	0.4	-0.1	-0.6	0.6
Qualifications: nursing, teaching	0.7	1.0	1.2	1.0	1.1	-0.9
Commuting to job workplace: Walk	0.1	0.1	0.3	0.5	0.0	-0.2
Eye problems/disorders: Cataract	2.7	3.2	3.3	1.8	1.8	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.1	-1.0	-1.0	1.1
Medication for cholesterol	0.6	0.9	1.1	-1.1	-0.8	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.4	0.9	1.2	-1.2
Back pain experienced in last month	1.2	1.7	2.2	-1.4	-1.1	1.5
Mineral and other dietary supplements	0.8	1.1	1.5	-0.8	-1.1	1.2
Breast cancer (self-reported)	2.3	2.8	3.4	1.6	1.8	-1.6
Asthma (self-reported)	6.6	13.2	14.8	-3.9	-3.4	3.6
Osteoporosis (self-reported)	0.1	0.2	0.4	0.6	0.2	-0.3
Osteoarthritis (self-reported)	2.2	2.9	3.8	-1.7	-1.4	1.9
Medication: Aspirin	5.2	6.8	8.4	2.9	2.4	-2.5
Medication: Gliclazide	0.3	0.4	0.7	0.9	0.3	-0.5
Illnesses of father: None of the above (group 1)	2.8	3.4	4.0	-1.9	-1.6	2.0
Smoking status: Current	0.7	1.1	1.1	-1.0	-1.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.0	1.0	1.0	-0.9
Whole body water mass	0.0	0.0	0.0	-0.1	0.1	0.2
Leg predicted mass (right)	0.0	0.2	0.4	-0.5	-0.3	0.6
Arm fat mass (left)	0.1	0.3	0.5	-0.6	-0.5	0.7
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.2	0.1	-0.1
Average weekly champagne plus white wine intake	0.2	0.2	0.3	0.3	0.5	-0.5
Miserableness	5.2	8.9	9.7	-2.8	-3.1	3.1
Guilty feelings	0.9	1.3	1.7	-1.3	-0.9	1.2
Wears glasses or contact lenses	7.4	8.5	9.4	2.8	3.1	-2.9
Ever taken oral contraceptive pill	3.5	3.8	4.3	-2.1	-1.9	1.9
Hearing aid user	0.2	0.2	0.5	0.7	0.4	-0.3
Mother’s age at death	0.1	0.2	0.4	0.4	0.2	-0.6
Financial situation satisfaction	0.7	0.8	1.1	-0.8	-1.0	0.9
Tinnitus: Yes, now most or all of the time	0.7	0.9	1.0	0.9	1.0	-0.9
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.6	0.2	0.1
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	0.1	0.1	-0.2
Medication: Blood pressure	2.3	4.3	5.9	2.4	1.7	-2.0
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.3	-0.8	-0.6	1.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	0.8	-0.9	-0.9	0.7
High cholesterol (Self-reported)	3.8	6.7	7.6	2.8	2.3	-2.7
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.2	-0.3	-0.4
Medication: Paracetamol	2.1	3.2	3.4	-1.7	-1.8	1.8
Medication: Lisinopril	3.0	3.8	4.0	2.0	1.9	-2.0
Medication: Atorvastatin	0.1	0.1	0.1	0.1	-0.3	0.4
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.6	0.3	-0.2
Alcohol drinker status: Never	0.3	0.3	0.7	-0.8	-0.3	0.5
Ever smoked	0.6	1.0	1.2	-1.1	-0.8	1.1
Basal metabolic rate	0.0	0.0	0.0	-0.1	0.1	0.2
Leg fat percentage (left)	0.1	0.2	0.3	0.4	0.6	-0.3
Arm fat-free mass (left)	0.1	0.5	0.8	0.7	0.9	-0.6
Number of operations (self-reported)	0.4	0.5	0.8	0.3	0.9	-0.9
Average weekly beer plus cider intake	0.8	1.1	1.6	0.9	1.3	-0.9
Irritability	0.2	0.4	0.5	0.6	0.7	-0.5
Risk taking	3.2	4.7	5.2	1.9	2.2	-2.3
Ever had prostate specific antigen (PSA) test	3.4	3.9	4.5	2.1	1.8	-2.0
Fractured/broken bones in last 5 years	3.4	4.4	5.2	2.0	2.3	-1.9
Age started oral contraceptive pill	0.4	0.6	0.7	0.9	0.7	-0.7
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.5	0.0	-0.3
Ever depressed for a whole week	1.8	2.2	2.2	-1.5	-1.5	1.4
Unable to work because of sickness or disability	0.0	0.0	0.0	-0.2	0.1	-0.1
Commuting to job workplace: Cycle	1.9	2.3	2.4	1.5	1.5	-1.5
Myopia	3.1	4.5	5.3	2.3	1.9	-2.1
Vascular/heart problems diagnosed by doctor	1.7	4.7	5.9	-2.4	-1.9	2.2
Cholesterol lowering medication	3.4	5.0	5.7	2.4	2.1	-2.2
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	3.5	1.7	1.9	-1.4
Pain experienced in last month	1.5	2.5	3.5	1.4	1.4	-1.9
Supplements: Calcium	1.4	1.6	1.7	1.3	1.2	-1.3
Basal cell carcinoma (self-reported)	4.8	5.8	6.4	2.4	2.5	-2.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.0	0.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.8	-0.7	-0.7	0.9
Heart disease (siblings)	1.0	1.2	1.4	-1.0	-1.2	1.1
Alcohol drinker status: Previous	0.3	0.4	0.5	-0.5	-0.7	0.5
Pack years of smoking	0.9	1.4	1.7	1.2	1.3	-1.0
Impedance of whole body	0.0	0.1	0.2	-0.5	-0.4	0.1
Leg fat mass (left)	0.0	0.1	0.2	0.2	0.4	-0.1
Arm predicted mass (left)	0.0	0.2	0.4	0.4	0.6	-0.3