TWAS hub - DLG1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.3700	0.1070	9.8e-04	0.026	NA	0.013	NA	0.028	7.3e-02	NA	1.5e-01	NA	6.3e-02
2	GTEx	Brain Cerebellum	0.4210	0.0820	1.3e-07	0.273	NA	0.386	NA	0.406	1.0e-08	NA	1.9e-12	NA	3.8e-13
3	GTEx	Cells Transformed fibroblasts	0.1200	0.0490	3.4e-03	-0.003	NA	-0.001	NA	-0.003	6.6e-01	NA	4.1e-01	NA	6.0e-01
4	GTEx	Muscle Skeletal	0.0862	0.0318	1.1e-04	0.007	NA	0.021	NA	0.008	6.7e-02	NA	3.7e-03	NA	4.9e-02
5	GTEx	Skin Not Sun Exposed Suprapubic	0.1200	0.0450	7.2e-04	0.030	NA	0.010	NA	0.018	9.2e-03	NA	8.6e-02	NA	3.3e-02
6	GTEx	Skin Sun Exposed Lower leg	0.1590	0.0390	5.4e-09	0.080	NA	0.106	NA	0.102	3.6e-07	NA	4.4e-09	NA	9.2e-09
7	GTEx	Testis	0.2010	0.0540	6.4e-07	0.153	NA	0.127	NA	0.143	2.7e-07	NA	3.1e-06	NA	7.0e-07
8	GTEx	Thyroid	0.3230	0.0510	0.0e+00	0.394	NA	0.400	NA	0.397	6.1e-32	NA	1.4e-32	NA	2.6e-32
9	METSIM	Adipose	0.0532	0.0183	4.1e-04	0.038	0.028	0.043	0.035	0.040	2.2e-06	4.3e-05	4.9e-07	5.5e-06	9.4e-07
10	TCGA	Thyroid Carcinoma	0.0730	0.0350	2.0e-05	0.050	0.052	0.049	NA	0.051	1.3e-05	8.4e-06	1.3e-05	NA	1.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Number of incorrect matches in round	4.7	7.8	13.0	1.1	2.2	2.4	3.5	3.2	3.6	3.1	3.2	-0.6	3.2
Lung FVC	4.6	23.4	44.3	0.4	-3.5	-6.0	-6.6	-3.2	-6.0	-4.0	-3.4	6.7	-4.8
Mean Putamen Volume	4.4	5.1	8.2	-0.6	-2.6	-2.6	-2.9	-2.1	-2.6	-2.4	-2.3	1.6	-2.1
Hand grip strength (right)	4.4	12.0	22.2	0.8	-1.8	-4.2	-4.7	-3.1	-4.2	-3.5	-3.4	2.4	-4.3
Peak expiratory flow (PEF)	3.8	8.8	21.1	-0.1	-2.1	-4.6	-4.5	-1.4	-2.9	-2.1	-1.8	3.7	-3.3
Forced vital capacity (FVC), Best measure	3.8	13.9	37.0	-0.6	-3.1	-6.1	-5.0	-1.6	-3.9	-2.5	-2.1	5.3	-3.2
Forced vital capacity (FVC)	3.4	13.1	34.9	-0.1	-2.9	-5.9	-4.7	-1.5	-3.8	-2.4	-1.8	5.6	-2.9
Loud music exposure frequency	3.4	3.7	9.6	-0.2	0.2	-1.4	1.4	3.1	1.4	2.5	2.7	1.5	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.1	24.6	-0.1	-2.2	-5.0	-4.2	-1.3	-3.5	-1.9	-1.6	4.2	-2.5
Diastolic blood pressure, automated reading	2.8	8.5	13.4	-0.2	-1.5	-3.6	-3.1	-3.5	-3.7	-3.5	-3.5	1.6	-2.9
Hand grip strength (left)	2.6	7.0	16.4	-0.0	-2.4	-2.1	-4.1	-2.3	-2.7	-2.9	-2.7	1.8	-3.3
Forced expiratory volume in 1-second (FEV1)	2.6	8.7	22.8	0.5	-1.8	-4.8	-4.2	-1.2	-3.4	-1.8	-1.4	4.4	-2.4
Hypothyroidism/myxoedema (self-reported)	2.6	5.1	13.2	1.0	-0.3	0.1	-3.6	-3.0	-1.9	-2.8	-2.8	0.9	-2.6
Body Mass Index (BMI) (2010)	2.4	3.2	6.9	-0.6	0.8	-2.6	2.0	2.4	0.7	2.5	2.2	-1.3	1.3
Back pain experienced in last month	2.4	3.5	8.3	1.2	-1.6	-1.7	-2.4	-1.2	-2.4	-1.6	-1.4	2.9	-1.5
Financial difficulties in last 2 years	2.3	3.1	13.1	1.6	-0.6	-3.6	-1.3	-0.5	-2.2	-0.7	-0.4	2.5	-1.0
Myopia	2.3	3.3	5.6	-0.9	-0.3	-1.0	-2.1	-2.4	-2.1	-2.1	-2.4	-1.6	-2.1
Type 2 Diabetes (T2D) (2012)	2.2	2.6	4.9	-2.1	-2.2	-0.9	-1.3	-1.4	0.1	-2.0	-1.9	1.3	-1.5
Number of children fathered	2.2	2.4	5.5	-0.1	-0.7	1.7	-1.7	-2.3	-1.4	-1.9	-1.8	1.5	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	10.5	0.6	-1.5	-1.9	-3.2	-1.9	-2.7	-2.1	-1.9	2.6	-1.8
Time employed in main current job	2.1	2.4	4.7	1.6	1.3	1.7	1.9	1.2	1.6	1.4	1.2	-2.2	1.0
Hair/balding pattern: Pattern 3	2.1	3.2	7.4	-1.1	-1.8	-1.5	-1.6	-2.0	-1.5	-2.1	-2.1	-0.4	-2.7
Impedance of arm (left)	2.1	9.6	18.4	-1.1	0.8	4.3	4.0	2.6	4.2	2.8	2.7	-2.7	3.6
Illnesses of father: Heart disease	2.1	2.9	6.0	-0.8	-1.4	-2.5	-1.8	-1.6	-2.0	-1.6	-1.7	0.8	-2.1
Unable to work because of sickness or disability	2.1	2.7	4.7	-1.3	-2.2	-1.4	-1.6	-1.6	-1.0	-2.1	-2.0	0.8	-1.8
HbA1C	2.0	2.2	3.9	-0.6	-2.0	-2.0	-1.6	-1.3	-1.1	-1.6	-1.3	1.6	-1.1
Had menopause	2.0	2.5	7.6	2.8	1.8	-0.7	1.5	1.2	0.3	1.7	1.8	0.5	1.8
Neck or shoulder pain in last month	2.0	2.9	13.3	2.7	0.4	-1.3	-0.9	-0.3	-2.3	-0.3	0.1	3.7	-0.2
Alcohol drinker status: Previous	2.0	2.3	5.8	-1.3	-1.9	-0.5	-1.8	-0.6	-1.6	-1.3	-0.8	2.4	-1.7
Hypothyroidism (self reported)	1.9	4.4	13.0	-0.1	-1.3	-0.1	-3.6	-2.5	-1.6	-2.5	-2.5	1.3	-2.6
Medication: Paracetamol	1.9	3.1	6.0	1.7	1.3	1.0	1.5	2.4	0.4	2.2	2.5	1.6	2.0
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.2	-1.5	0.2	0.9	1.4	2.0	1.5	1.8	2.0	0.5	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	6.6	2.0	2.6	0.9	1.0	1.0	0.3	1.5	1.3	-1.7	1.5
Medication: Paracetamol	1.9	3.0	8.3	2.9	2.0	0.9	1.2	1.7	-0.3	1.8	2.0	1.3	1.9
Body fat percentage	1.8	7.2	35.7	-0.5	3.1	1.0	3.1	1.4	2.1	2.4	1.5	-6.0	1.3
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	5.2	-0.6	-0.2	2.0	0.1	-0.8	2.3	-0.7	-0.9	-2.2	-1.4
Trunk fat percentage	1.7	6.8	35.2	-0.5	3.1	1.4	2.9	1.1	2.0	2.2	1.3	-5.9	1.2
Hair/balding pattern: Pattern 2	1.7	2.2	4.2	-0.1	0.9	0.5	1.6	1.9	1.7	2.0	2.0	0.1	1.9
Impedance of arm (right)	1.7	7.7	18.5	-1.5	0.4	3.3	3.6	2.4	4.3	2.5	2.5	-2.4	3.1
Shortness of breath walking on level ground	1.7	2.0	5.5	2.3	2.3	-1.0	-0.7	-1.2	-1.9	-0.4	-0.8	-1.0	-0.9
Financial situation satisfaction	1.7	2.1	4.2	1.8	0.9	-1.0	1.2	2.0	0.2	1.9	2.0	0.9	1.3
Leg fat percentage (left)	1.7	6.2	31.1	-0.3	3.2	0.5	2.8	1.3	1.8	2.2	1.3	-5.6	0.9
Schizophrenia (2018)	1.6	3.3	5.9	-1.9	0.3	-0.8	2.4	1.8	1.9	2.2	1.9	-2.3	1.5
Heel T-Score	1.6	12.7	26.2	-3.6	0.6	3.9	4.4	2.9	5.1	2.5	2.1	-5.1	2.8
Waist Hip Ratio (WHR)	1.6	7.0	38.8	6.2	4.1	-0.9	-1.3	-1.3	-2.9	-0.2	-0.4	0.7	-1.1
Average weekly fortified wine intake	1.6	1.9	5.8	0.6	-0.2	0.2	-2.3	-1.2	-2.4	-1.2	-1.1	1.5	-1.0
Medication: Levothyroxine sodium	1.6	2.7	8.9	0.6	-0.5	1.0	-3.0	-1.9	-0.9	-2.0	-1.8	1.4	-1.6
Breastfed as a baby	1.6	2.0	4.9	0.1	-0.0	0.1	-1.6	-2.2	-2.2	-1.6	-1.8	-0.4	-1.2
Illnesses of siblings: Diabetes	1.6	2.0	4.9	1.3	2.0	1.1	1.7	0.9	0.9	1.2	0.9	-2.2	1.1
Commuting to job workplace: Cycle	1.6	1.9	3.7	-0.5	-1.0	-1.0	-1.9	-1.8	-1.9	-1.5	-1.5	0.4	-1.3
Serious illness, injury or assault to yourself	1.5	1.8	3.6	-1.6	-1.9	-1.2	-1.0	-1.6	-1.1	-1.5	-1.5	-0.1	-1.2
Nervous feelings	1.5	2.8	7.9	1.2	1.4	-0.3	2.8	1.7	1.1	2.1	2.0	-0.5	2.1
Medication: Lansoprazole	1.5	1.7	4.9	1.5	0.2	-0.8	-2.0	-0.9	-2.2	-1.0	-1.1	0.8	-1.2
Wheeze or whistling in the chest in last year	1.5	2.8	6.4	-0.7	0.5	1.4	2.0	1.8	2.5	2.0	1.9	-0.9	1.7
Mean time to correctly identify matches	1.5	2.8	6.8	2.3	2.2	1.3	1.5	1.1	0.9	1.6	1.5	-0.4	2.6
Leg pain on walking	1.5	1.9	5.9	2.4	2.2	1.9	1.4	-0.0	-0.4	0.7	0.6	-0.1	1.3
Mood swings	1.5	2.8	5.6	0.2	1.0	-0.2	2.4	2.1	1.2	2.3	2.4	0.8	1.9
Pain experienced in last month	1.5	2.5	11.2	-3.3	-1.3	1.2	-0.0	-0.5	1.4	-0.7	-0.9	-2.5	-1.0
Schizophrenia (2014)	1.4	3.2	5.4	-1.5	0.5	-0.3	2.0	1.8	2.3	2.2	1.9	-2.1	1.8
Vitamin and mineral supplements	1.4	1.9	4.3	-2.1	-1.0	0.5	-1.6	-1.3	-0.4	-1.7	-1.7	-0.9	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	7.8	1.9	0.5	-1.6	-1.0	-1.2	-2.8	-0.7	-0.8	0.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	10.7	-2.5	0.0	0.6	2.5	0.9	2.1	1.0	0.7	-3.3	1.0
Worrier / anxious feelings	1.4	2.6	4.9	0.2	0.1	-0.5	2.0	2.2	1.3	1.9	2.1	1.6	2.0
Illnesses of mother	1.4	1.7	5.2	2.3	2.1	1.8	0.5	0.1	-0.7	1.0	0.9	0.4	1.2
Leg fat percentage (right)	1.4	5.0	24.2	-0.3	2.8	0.2	2.5	1.4	1.5	2.1	1.4	-4.9	0.9
Arm fat percentage (left)	1.4	5.7	33.6	-1.0	2.5	0.9	2.5	0.9	1.7	1.8	1.0	-5.8	0.8
Impedance of whole body	1.4	6.9	15.0	-0.6	0.7	3.3	3.7	2.4	3.9	2.4	2.4	-1.7	2.9
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	10.6	-2.6	-0.2	0.5	2.2	0.6	2.2	0.7	0.4	-3.3	0.6
Trunk predicted mass	1.3	7.3	18.1	2.1	0.4	-4.3	-3.7	-1.8	-4.2	-1.5	-1.6	2.2	-2.4
Alcohol intake frequency.	1.3	3.0	6.2	-2.3	-2.5	-1.1	-1.9	-0.6	0.1	-1.6	-1.2	1.8	-2.4
Suffer from ‘nerves’	1.3	2.1	4.4	0.4	0.9	-1.5	2.1	1.7	0.8	1.7	1.8	0.2	1.9
Mineral and other dietary supplements	1.3	1.7	4.8	-2.2	-1.3	-0.1	-0.9	-1.0	-0.5	-1.0	-1.3	-1.8	-1.6
Mother’s age at death	1.3	1.6	7.2	2.7	2.3	0.8	0.2	0.4	-0.1	1.0	0.8	-0.7	0.9
Number of treatments/medications taken	1.2	2.2	9.3	3.0	2.3	-0.9	0.1	0.2	-1.4	1.2	1.0	0.6	1.2
Fluid intelligence score	1.2	2.6	8.5	-2.9	-2.0	-1.5	-0.9	-1.2	-0.2	-1.4	-1.5	-1.0	-1.9
Arm fat percentage (right)	1.2	4.8	30.6	-1.2	2.2	0.4	2.1	0.7	1.6	1.5	0.7	-5.5	0.4
Trunk fat-free mass	1.2	7.1	18.1	2.1	0.4	-4.3	-3.6	-1.7	-4.2	-1.5	-1.6	2.2	-2.4
Ever had bowel cancer screening	1.2	1.4	3.1	-1.8	0.8	1.4	1.3	0.7	0.9	1.0	0.8	-1.3	1.6
Friendships satisfaction	1.2	1.5	3.2	-1.8	-0.8	-0.4	1.3	1.7	1.6	1.1	1.2	-0.1	0.9
Wears glasses or contact lenses	1.2	1.4	4.0	-0.8	-1.1	-0.1	-1.1	-1.6	-2.0	-1.3	-1.3	0.8	-0.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	8.0	1.9	0.7	-0.7	-0.0	0.5	-0.3	0.6	0.9	2.8	1.1
Intelligence (Savage-Jansen 2018)	1.1	3.3	7.6	-2.8	-1.9	-0.7	-1.6	-1.6	-0.4	-1.9	-2.1	-1.6	-2.3
Major Depression (MDD)	1.1	1.3	3.6	-0.1	-1.9	-1.4	-1.2	-0.3	-1.0	-1.0	-0.8	1.7	-0.5
Reaction Time	1.1	2.1	5.9	2.4	1.8	1.7	1.0	0.9	0.6	1.1	1.2	0.6	1.9
Average weekly spirits intake	1.1	1.4	7.0	2.6	1.4	2.0	-0.5	-0.6	-0.4	-0.2	-0.1	0.5	0.4
High blood pressure (mother)	1.1	1.5	3.7	-1.4	-1.9	-0.9	-1.0	-0.9	0.3	-1.4	-1.3	0.8	-1.3
Knee pain experienced in last month	1.1	1.7	3.7	0.7	1.0	-0.6	1.4	1.9	1.2	1.4	1.7	0.7	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.3	0.2	0.6	1.2	1.4	1.2	1.3	1.3	1.3	0.1	1.5
Osteoporosis (self-reported)	1.1	1.3	3.0	-1.5	-0.6	-1.0	1.2	1.4	1.7	0.9	1.1	-0.1	1.1
Guilty feelings	1.1	1.7	6.8	1.8	1.6	-2.6	0.8	0.2	-1.0	0.5	0.2	-1.4	-0.1
Eye problems/disorders: Glaucoma	1.1	1.3	5.8	1.4	1.1	2.4	0.7	0.5	0.1	0.9	0.8	-0.4	1.5
Arm fat-free mass (left)	1.1	5.4	14.1	2.2	1.2	-3.8	-2.9	-1.5	-3.6	-1.2	-1.4	0.9	-2.3
Risk taking	1.1	1.6	5.5	2.3	2.0	-1.0	0.2	0.2	-2.0	0.9	0.6	-0.1	0.4
Verbal and Numeric Reasoning (VNR)	1.0	2.5	6.0	-2.4	-2.2	-1.7	-0.8	-1.2	-0.0	-1.6	-1.6	-0.5	-1.9
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.0	0.8	-0.5	-1.3	-1.3	-1.4	-1.4	-1.4	-1.4	0.9	-0.8
Diabetes (mother)	1.0	1.3	3.5	-0.4	-0.3	-0.9	-0.8	-1.1	-0.7	-1.4	-1.6	-1.3	-1.9
Severe depression (siblings)	1.0	1.1	2.5	-1.6	-1.2	0.7	0.1	-0.7	0.8	-1.0	-1.2	-1.6	-0.9
Townsend deprivation index at recruitment	1.0	1.3	4.3	2.1	1.3	-1.4	0.1	0.5	-1.3	0.7	0.8	1.5	0.5
Trunk fat mass	1.0	4.4	24.8	0.1	3.0	0.1	1.9	0.8	0.9	1.8	1.0	-5.0	0.7
Alcohol intake versus 10 years previously	1.0	1.5	6.3	-0.6	1.6	1.0	0.6	0.6	1.5	1.1	0.8	-2.5	0.6
Number of live births	1.0	1.4	3.3	-1.0	-1.0	-1.0	-0.9	-1.3	-0.6	-1.5	-1.4	0.1	-1.8
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.6	-0.9	-0.0	-0.6	1.5	1.1	1.6	1.1	1.1	-0.5	1.1
Exposure to tobacco smoke at home	1.0	1.2	2.4	1.2	1.5	0.5	1.1	1.1	0.0	1.2	1.1	-0.8	1.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.7	-1.1	-1.5	-1.4	-0.5	-0.8	-1.2	-1.2	-1.3	-0.4	-2.2
Arm fat-free mass (right)	1.0	5.3	14.8	2.6	1.4	-3.4	-2.8	-1.6	-3.9	-1.1	-1.3	0.9	-2.0
Medication for pain relief, constipation, heartburn	1.0	1.7	3.4	-1.6	-1.4	-1.8	-0.8	-1.1	-0.4	-1.3	-1.5	-0.7	-1.6
Medication: Allopurinol	1.0	1.4	3.8	-0.9	-0.1	1.4	1.2	1.2	1.3	1.1	1.3	0.1	1.9
Arm predicted mass (right)	1.0	5.0	13.8	2.4	1.4	-3.6	-2.6	-1.3	-3.7	-0.9	-1.1	1.1	-1.9
Supplements: Vitamin C	1.0	1.2	8.5	2.9	1.2	-0.2	0.4	-0.1	-1.1	0.3	0.2	0.4	0.7
Average weekly beer plus cider intake	1.0	1.4	4.7	2.2	1.4	1.1	-1.1	-0.7	-1.9	-0.6	-0.6	-0.0	-0.7
Ever had prostate specific antigen (PSA) test	1.0	1.1	7.3	-0.9	-0.1	2.7	-0.5	-1.0	0.4	-0.8	-0.8	-0.4	-0.2
Arm predicted mass (left)	1.0	5.2	14.8	2.1	1.1	-3.9	-2.9	-1.4	-3.5	-1.0	-1.2	1.2	-2.1
Bipolar Disorder or Schizophrenia	0.9	2.3	4.0	-0.8	0.9	-0.9	1.6	1.8	1.5	2.0	1.8	-1.6	1.6
Neuroticism (2016)	0.9	1.3	4.7	0.5	-1.5	-1.6	-0.6	-0.5	-1.4	-0.8	-0.5	2.2	-0.2
Sensitivity / hurt feelings	0.9	1.6	4.0	0.8	-0.1	-0.6	1.1	1.4	0.3	1.4	1.6	1.9	2.0
Ever used hormone-replacement therapy (HRT)	0.9	1.2	4.0	2.0	1.3	-0.6	0.3	1.1	1.1	1.0	1.1	0.5	0.9
Lung cancer (father)	0.9	1.1	2.8	-1.2	-1.7	0.6	-0.6	-0.9	-0.1	-1.2	-0.9	1.2	-1.2
Length of working week for main job	0.9	1.0	1.6	1.2	1.2	0.3	0.8	1.0	-0.1	1.1	1.2	1.1	1.1
Birth weight of first child	0.9	1.6	4.9	0.2	-0.5	-1.2	-1.6	-0.7	-2.2	-0.9	-0.8	1.7	-1.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	5.6	0.9	1.5	-0.6	0.8	-1.0	-0.2	-0.2	-0.7	-2.4	-0.6
Comparative body size at age 10	0.9	2.4	8.5	0.7	1.8	-0.4	0.5	-1.4	-2.7	-0.1	-0.8	-2.9	-1.2
Medication: Ibuprofen	0.9	1.1	6.4	2.5	0.8	-1.3	-0.0	-0.3	-1.3	0.2	0.2	-0.5	-0.1
Whole body fat mass	0.9	3.7	22.2	0.1	2.9	-0.2	1.5	0.6	0.6	1.5	0.7	-4.7	0.5
Leg fat mass (right)	0.9	3.5	18.4	0.3	2.9	-0.7	1.5	1.0	0.6	1.8	1.0	-4.3	0.5
Had major operations	0.9	1.0	3.2	0.5	0.6	1.0	1.2	0.7	1.1	1.1	1.1	-0.4	1.8
Smoking status: Previous	0.9	1.3	3.4	0.8	1.0	1.5	1.1	0.5	0.5	1.3	1.2	-0.8	1.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.7	0.7	0.5	-0.3	1.3	1.1	-0.0	1.6	1.5	-0.4	1.4
Medication: Lisinopril	0.9	1.2	2.8	0.7	1.5	1.2	1.3	0.6	1.0	1.0	0.9	-0.8	1.7
Leg fat mass (left)	0.9	3.7	20.3	0.3	3.0	-0.6	1.6	0.9	0.6	1.7	0.9	-4.5	0.3
Ovarian Cancer	0.8	1.0	4.4	0.2	1.1	1.2	-0.4	-1.1	0.1	-0.8	-1.0	-2.1	-0.6
Systolic Blood Pressure	0.8	4.1	8.8	1.2	0.0	-2.3	-1.7	-2.8	-2.4	-2.2	-2.0	3.0	-0.8
Systolic blood pressure, automated reading	0.8	2.4	6.8	0.6	-0.6	-2.6	-1.3	-1.9	-1.6	-1.6	-1.5	1.6	-0.9
Pack years adult smoking proportion	0.8	1.2	5.2	1.1	0.3	-0.6	0.7	0.9	-0.0	1.0	1.3	2.3	1.2
Relative age voice broke	0.8	1.2	2.1	0.9	1.4	0.2	1.5	1.1	-0.0	1.4	1.3	-1.3	0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	6.4	0.3	-1.0	0.4	-0.3	-0.3	0.1	-0.5	-0.2	2.5	0.0
Waist circumference	0.8	3.1	11.0	1.7	3.2	-1.7	0.4	-0.6	-1.4	0.5	-0.3	-3.3	-0.8
Heart attack	0.8	1.0	3.8	2.0	1.5	0.0	0.2	0.4	-0.4	0.9	0.9	1.0	0.8
Neuroticism score	0.8	1.6	3.4	1.0	1.0	-1.7	1.8	1.1	-0.1	1.4	1.5	0.8	1.3
Falls in the last year	0.8	1.1	4.0	0.5	1.1	-1.1	2.0	0.9	0.9	0.8	0.7	-0.7	1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	3.3	1.8	0.3	1.8	-1.0	-1.6	-0.3	-1.2	-1.1	0.6	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	6.9	2.6	1.4	-0.2	0.3	-0.0	-1.0	0.5	0.5	-0.2	0.4
Whole body fat-free mass	0.8	4.8	12.8	2.0	1.1	-3.6	-3.0	-1.3	-3.6	-1.0	-1.1	1.2	-1.8
Loneliness, isolation	0.8	1.1	2.9	1.4	1.1	-1.5	1.0	-0.3	-1.7	0.1	-0.1	-1.0	0.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.2	-1.5	-1.1	-0.5	1.3	-1.3	0.9	-1.1	-1.2	-1.3	-0.9
Osteoarthritis (self-reported)	0.8	1.1	2.4	-1.4	-1.4	1.3	0.2	-0.3	1.5	-0.7	-0.4	1.3	-0.3
Whole body water mass	0.8	4.7	12.5	2.1	1.1	-3.5	-2.9	-1.3	-3.5	-0.9	-1.1	1.2	-1.8
Hearing aid user	0.8	1.0	2.3	1.5	-0.2	1.2	-0.7	-1.4	-1.0	-1.0	-1.0	0.5	-0.4
Depressed Affect (Nagel 2018)	0.7	1.4	2.5	-0.7	-0.2	-0.6	1.5	1.6	1.6	1.4	1.6	0.6	1.2
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.3	1.8	0.8	-1.4	0.4	-0.2	-1.8	0.1	0.1	0.7	-0.1
Supplements: Zinc	0.7	0.7	4.8	0.8	-0.7	0.3	-1.0	-0.2	-0.1	-0.6	-0.3	2.2	0.1
Medication: Metformin	0.7	0.9	3.2	1.4	1.8	-1.1	0.6	0.6	0.4	1.0	0.8	-0.8	0.2
Qualifications: CSEs or equivalent	0.7	1.0	3.3	1.0	-0.6	-1.8	1.1	0.3	-0.6	0.4	0.5	1.6	0.8
Impedance of leg (left)	0.7	3.6	8.3	0.3	0.9	1.9	2.9	2.0	2.8	2.0	2.0	-0.7	1.9
Diabetes (self-reported)	0.7	1.1	6.6	0.8	1.5	0.7	0.2	-0.5	0.6	0.1	-0.3	-2.6	-0.9
Emphysema/chronic bronchitis	0.7	0.8	2.6	-0.3	-0.3	0.5	1.6	0.6	1.4	0.8	0.8	-0.4	1.0
Family relationship satisfaction	0.7	0.9	3.3	-1.8	-0.9	-0.8	0.8	1.4	0.4	0.8	0.8	0.2	0.3
Average weekly red wine intake	0.7	1.0	3.7	-0.1	-0.7	-1.7	-1.0	-1.0	-1.9	-0.5	-0.7	0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	3.5	-1.9	-0.4	-1.0	0.0	0.3	0.2	0.2	-0.1	-1.4	-0.5
Medication for cholesterol	0.7	1.0	6.1	-2.5	-1.6	0.3	-0.8	-0.3	0.1	-0.4	-0.3	-0.1	-0.4
High cholesterol (Self-reported)	0.7	1.2	3.8	1.9	1.2	-1.3	-0.1	0.2	-1.3	0.7	0.7	1.4	0.4
Basal metabolic rate	0.7	3.8	11.0	1.8	1.3	-3.3	-2.5	-1.2	-3.2	-0.8	-1.0	0.3	-1.7
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.4	1.8	1.5	-0.3	0.2	0.4	-0.4	0.9	0.9	1.0	0.8
Heart disease (siblings)	0.7	0.8	2.7	0.6	1.7	0.8	0.6	0.6	0.6	0.9	0.9	-0.1	1.2
Pack years of smoking	0.7	1.1	4.7	0.7	0.0	-0.3	0.7	1.0	0.5	0.9	1.3	2.2	1.3
Age at First Birth	0.6	0.9	2.6	0.1	-0.6	1.2	-0.2	-0.8	-0.2	-1.1	-1.3	-1.6	-0.8
Rheumatoid Arthritis	0.6	0.8	3.8	1.1	-0.3	-0.2	-0.6	0.5	-0.1	0.6	0.9	1.9	1.2
Respiratory disease	0.6	1.4	4.1	-1.4	-0.2	2.0	1.2	0.7	1.3	0.7	0.6	-1.5	1.0
Neuroticism	0.6	1.5	3.8	0.8	0.6	-0.5	1.6	1.3	0.5	1.5	1.7	0.7	1.9
Ever had hysterectomy (womb removed)	0.6	0.7	3.6	1.9	0.6	1.4	-0.2	0.4	-0.1	0.3	0.4	0.4	0.8
Angina	0.6	0.8	2.6	0.2	-0.6	-0.3	-0.4	1.1	1.3	0.7	1.0	1.6	0.7
Impedance of leg (right)	0.6	2.8	5.8	0.3	0.3	1.3	2.3	2.0	2.4	1.9	1.9	0.1	1.9
Current tobacco smoking	0.6	1.0	2.6	1.0	-0.3	-0.8	-1.3	-0.4	-1.6	-0.7	-0.8	1.2	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	3.8	2.0	1.5	-0.3	1.3	0.1	-0.7	0.7	0.6	-0.3	0.5
Qualifications: None of the above	0.6	1.3	3.0	1.0	0.8	1.7	0.3	0.9	0.8	0.8	1.2	1.6	1.6
Mouth/teeth dental problems	0.6	1.0	2.4	-0.6	-0.4	-0.8	-1.0	1.4	-0.6	0.9	1.0	1.5	0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.1	-1.3	-1.3	1.2	-0.2	0.5	1.0	0.1	0.3	1.4	-0.0
Happiness	0.6	0.8	3.1	-0.5	-0.4	-1.8	0.8	1.1	-0.1	0.9	0.8	-0.9	-0.0
Noisy workplace	0.6	0.7	2.9	1.0	1.0	1.7	-0.8	-0.4	-1.0	-0.2	-0.1	0.5	0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.3	8.9	-0.1	0.2	-0.9	0.5	-0.4	-0.2	-0.3	-0.7	-3.0	-1.5
Arm fat mass (right)	0.6	2.3	17.7	-0.5	1.8	-0.9	0.4	-0.4	-0.1	0.4	-0.4	-4.2	-0.8
Tense / ‘highly strung’	0.6	0.9	2.0	-0.0	0.3	-1.4	1.2	0.9	0.3	1.1	1.1	0.8	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.9	-0.2	0.6	-1.0	1.7	1.0	0.9	1.1	0.8	-1.1	0.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.2	-1.2	0.1	-0.1	1.0	0.5	0.9	0.2	0.1	-1.8	-0.2
Birth weight	0.6	1.3	3.1	0.3	-0.1	-0.3	-1.4	-1.8	-1.1	-1.6	-1.6	0.4	-1.2
Qualifications: College or University degree	0.6	1.8	11.6	-0.2	1.6	-0.8	1.6	0.3	0.1	0.6	0.2	-3.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	4.1	1.0	0.4	2.0	-0.5	-0.7	-0.1	-0.7	-0.7	0.3	-0.0
Diabetes diagnosed by doctor	0.6	1.0	3.4	1.6	1.8	0.3	0.3	-0.2	0.6	0.6	0.3	-1.8	-0.3
Smoking status: Current	0.6	0.9	3.1	0.9	-0.1	-0.9	-1.1	-0.4	-1.8	-0.6	-0.8	0.9	-1.1
Arm fat mass (left)	0.6	2.4	17.3	-0.3	2.1	-0.6	0.9	-0.1	0.0	0.7	-0.0	-4.2	-0.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.4	-1.6	-1.6	-0.8	-0.5	0.1	0.3	-0.2	-0.0	0.8	0.2
Cholesterol lowering medication	0.6	0.9	4.0	2.0	1.4	-0.4	1.1	0.4	-0.3	0.9	0.8	-0.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.8	-0.6	-1.4	-0.6	-1.0	0.3	0.8	-0.5	-0.0	1.7	0.5
Supplements: Calcium	0.6	0.7	2.3	0.4	-0.1	-0.0	1.1	0.4	0.9	0.4	0.7	1.1	1.5
Prostate Cancer	0.5	0.7	1.8	1.4	1.1	1.2	-0.0	0.1	-0.6	0.6	0.4	-0.0	1.2
Fasting Glucose	0.5	0.6	3.3	0.6	0.0	-1.8	-0.3	-0.6	-0.5	0.1	-0.5	0.7	-0.8
LDL Cholesterol	0.5	0.7	1.3	0.8	-0.0	-0.7	0.8	1.1	0.2	0.8	1.1	1.1	1.0
Primary Biliary Cirrhosis	0.5	0.7	2.4	-1.6	-0.9	-0.0	-0.1	-0.9	0.1	-1.0	-1.1	-0.6	-0.9
BMI	0.5	2.8	19.7	-1.7	1.2	-1.7	0.4	0.2	0.2	0.5	-0.2	-4.4	-1.1
Allergy or Eczema	0.5	1.2	4.4	-1.9	-2.1	-0.3	-0.5	0.7	1.5	-0.1	0.2	1.1	0.1
Chronotype (morning person)	0.5	1.1	3.9	-1.4	0.0	1.1	1.4	0.5	2.0	0.2	0.2	-1.0	0.8
Tanning	0.5	6.5	16.0	-0.6	-2.6	0.1	-4.0	-2.7	-2.6	-3.0	-2.7	2.5	-2.3
Leg fat-free mass (left)	0.5	2.4	6.6	1.5	1.5	-2.5	-2.0	-0.8	-2.6	-0.3	-0.6	-0.4	-1.1
Fed-up feelings	0.5	0.9	2.1	-0.6	-0.7	-1.3	1.0	1.1	0.7	0.7	1.0	1.4	0.3
Taking other prescription medications	0.5	0.8	2.2	0.7	-0.1	-0.7	-1.5	-1.0	-0.9	-0.9	-1.0	-0.1	-0.9
Medication: Atenolol	0.5	0.6	1.1	1.1	0.9	-0.7	0.7	0.8	0.2	0.9	0.9	-0.3	1.0
Body mass index (BMI)	0.5	2.2	14.7	-0.2	1.8	-1.1	0.2	-0.5	-0.6	0.1	-0.6	-3.8	-1.1
Medication: Simvastatin	0.5	0.7	2.3	1.5	0.9	0.1	0.0	0.4	-0.7	0.9	1.0	0.9	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	6.4	0.0	0.2	-2.5	0.3	-0.5	-0.9	-0.3	-0.4	-0.6	-0.6
Prospective memory result	0.5	0.6	2.9	1.7	1.4	0.4	-0.3	-0.4	-0.6	-0.1	-0.1	0.2	-0.2
Hair/balding pattern: Pattern 4	0.5	1.3	4.9	0.6	0.1	-2.2	-1.2	-0.5	-1.7	-0.3	-0.3	1.6	-0.5
Pulse wave reflection index	0.5	0.6	1.9	-0.4	-0.3	0.9	-1.4	-0.8	-0.1	-1.1	-1.1	0.4	-0.7
Headache pain in last month	0.5	0.8	4.5	0.8	-0.1	-1.3	-0.1	0.7	-0.7	0.3	0.6	2.1	0.1
Medication: Amlodipine	0.5	0.7	2.6	0.8	1.2	0.4	0.2	0.2	-0.2	0.8	0.7	0.8	1.6
Exposure to tobacco smoke outside home	0.5	0.7	1.2	-0.7	-0.6	-0.3	0.6	1.0	1.1	1.0	1.1	0.5	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.3	-1.0	0.1	-1.5	0.8	0.3	-0.2	0.5	0.2	-1.2	-0.4
Angina (self-reported)	0.5	0.7	1.6	0.5	-0.4	-0.1	-0.4	1.0	1.2	0.8	1.0	1.2	0.8
Migraine (self-reported)	0.5	0.6	1.6	0.4	-0.1	-0.9	1.2	0.9	0.8	0.6	0.8	1.2	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	-0.1	0.5	-1.2	0.9	1.1	0.8	0.8	0.8	-0.2	0.9
Ever taken oral contraceptive pill	0.5	0.5	2.1	1.5	0.7	-1.0	-0.4	-0.1	-0.9	0.2	0.2	0.6	-0.5
Commuting to job workplace: Public transport	0.5	0.6	2.5	-0.5	0.1	-1.0	1.0	0.5	0.4	0.7	0.5	-1.6	0.4
Medication: Atorvastatin	0.5	0.6	4.3	0.3	-0.0	-2.1	-0.7	-0.1	-0.9	0.0	0.1	0.4	-0.5
Alcohol drinker status: Never	0.5	0.7	1.7	-0.8	-1.2	1.3	-0.3	-0.8	0.8	-0.8	-0.8	0.0	-0.3
Number of operations (self-reported)	0.5	0.7	2.6	-0.2	-0.9	1.6	0.3	-0.4	1.4	-0.1	-0.1	-0.1	1.2
Fractured/broken bones in last 5 years	0.5	0.7	1.9	1.4	1.2	-1.4	-0.5	0.3	-1.0	0.3	0.2	0.3	0.3
Ever depressed for a whole week	0.5	0.6	2.7	-0.5	-1.7	-0.7	0.0	-0.0	0.9	-0.5	-0.2	0.9	-0.0
Basal cell carcinoma (self-reported)	0.5	0.6	2.3	0.5	0.7	0.7	-0.1	-0.1	0.6	-0.4	-0.5	-1.5	-1.1
Neuroticism (Nagel 2018)	0.4	0.8	1.4	-0.3	-0.5	-1.1	0.9	0.9	0.9	0.9	1.0	1.0	1.2
Worry (Nagel 2018)	0.4	0.9	2.1	-0.0	-0.2	-1.0	1.1	1.2	0.5	1.0	1.2	0.7	1.5
Alzheimer’s Disease (in mother)	0.4	0.5	3.2	-0.7	-0.4	0.4	0.4	0.4	1.8	0.0	0.1	-0.7	0.4
Alzheimer’s Disease (in father)	0.4	0.4	1.1	0.6	0.5	0.4	1.1	-0.3	-0.7	0.5	0.2	-0.9	0.6
Crohns Disease (2017)	0.4	0.8	4.0	1.0	0.5	2.0	0.4	-0.9	-0.1	-0.7	-0.8	-0.6	-0.3
Lupus	0.4	0.6	2.6	1.6	1.6	-0.2	0.4	0.1	-0.2	0.0	-0.1	-1.1	-0.0
Blood White Count	0.4	2.8	5.6	-2.2	0.1	0.7	1.7	1.7	1.7	1.8	1.4	-2.4	1.7
Cardiovascular Disease	0.4	1.4	4.4	1.3	0.1	-1.0	-0.6	-1.4	-2.1	-1.3	-1.2	0.9	-0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.2	1.1	1.7	0.0	0.3	-0.1	0.5	0.6	0.3	-1.8	-0.0
Lung FEV1/FVC ratio	0.4	1.9	6.6	2.6	1.0	1.2	-1.5	-1.8	-1.3	-0.9	-1.1	-0.4	-0.7
Relative age of first facial hair	0.4	0.7	2.0	-0.0	-0.2	1.2	1.0	1.1	1.4	0.8	0.9	-0.5	0.4
Medication for hormone replacement therapy	0.4	0.4	1.9	1.1	-0.2	0.1	0.1	0.6	0.6	0.1	0.3	1.4	0.5
Multivitamins +/- minerals	0.4	0.5	0.9	0.9	0.2	0.3	0.4	0.8	0.6	0.8	0.9	0.7	0.9
Leg predicted mass (left)	0.4	2.2	6.1	1.4	1.5	-2.4	-1.9	-0.7	-2.5	-0.2	-0.6	-0.5	-1.1
Past tobacco smoking	0.4	0.8	1.8	-0.9	-0.9	-0.8	-1.1	-0.4	-0.3	-1.1	-0.9	0.6	-1.4
Hearing difficulty/problems with background noise	0.4	0.7	1.5	-0.5	-0.6	-0.9	1.0	0.9	1.2	0.5	0.5	-1.1	0.2
Had other major operations	0.4	0.4	1.8	0.9	0.5	0.8	0.4	-0.5	0.6	-0.3	-0.4	-1.3	-0.0
Illnesses of siblings	0.4	0.6	1.7	-0.4	-1.3	-1.2	-0.3	-0.5	0.1	-0.7	-0.6	0.4	-0.8
Weight	0.4	1.9	5.4	1.0	2.1	-2.1	-0.7	-0.5	-1.6	0.2	-0.4	-2.3	-0.9
Hip circumference	0.4	1.7	11.7	-0.7	1.4	-1.1	0.7	0.0	-0.5	0.7	0.1	-3.4	-0.1
Blood clot in the leg (DVT)	0.4	0.5	4.0	0.5	-0.0	0.2	0.4	0.4	2.0	-0.1	0.1	0.0	-0.1
Number of full brothers	0.4	0.5	1.8	0.7	0.0	-1.1	-1.1	-0.4	-1.3	-0.2	-0.3	0.3	-0.4
Age at first live birth	0.4	0.8	1.5	-0.6	0.7	0.3	0.7	0.9	1.0	1.2	1.0	-1.2	0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.9	-0.3	0.9	-0.2	0.5	0.4	-0.6	0.7	0.4	-1.4	0.9
Medication: Seretide 50 evohaler	0.4	0.5	1.5	-0.7	-0.8	0.6	0.7	-0.8	0.3	-0.6	-0.7	-1.2	-0.1
Number of full sisters	0.4	0.4	1.7	0.1	0.6	-0.3	0.2	-0.6	-0.3	-0.6	-0.7	-1.3	-0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	0.1	-0.1	1.0	-1.0	-0.7	-0.5	-0.7	-0.8	-0.6	-0.7
Medication: Aspirin	0.4	0.5	1.0	1.0	0.7	0.9	0.0	0.6	0.0	1.0	0.9	0.4	1.0
Leg fat-free mass (right)	0.4	2.3	6.5	1.4	1.6	-2.3	-2.0	-0.9	-2.5	-0.4	-0.7	-0.4	-1.1
Commuting to job workplace: Walk	0.4	0.4	1.0	-0.7	-0.5	0.8	0.9	-0.3	0.9	-0.3	-0.3	-1.0	0.3
Eye problems/disorders: Cataract	0.4	0.5	1.6	1.2	0.4	1.2	-0.6	-0.5	-0.3	-0.6	-0.6	-0.5	-0.4
Breast cancer (self-reported)	0.4	0.5	2.5	0.2	0.3	-1.6	-0.3	-0.7	-0.7	-0.3	-0.4	0.9	-0.4
Leg predicted mass (right)	0.4	2.2	6.1	1.4	1.6	-2.3	-1.9	-0.8	-2.5	-0.3	-0.7	-0.5	-1.1
Average weekly champagne plus white wine intake	0.4	0.6	2.2	0.1	-0.8	-0.7	-1.0	-0.5	-0.8	-0.6	-0.5	1.5	-0.2
Medication: Blood pressure	0.4	0.7	1.6	1.3	0.8	0.3	0.0	-0.9	-0.3	-1.1	-1.1	-0.7	-0.9
Irritability	0.4	0.8	2.9	-1.2	-1.3	-0.4	0.6	0.5	0.3	0.3	0.6	1.7	0.4
Age started oral contraceptive pill	0.4	0.5	1.1	0.2	-0.1	0.4	-0.1	-0.9	0.4	-0.9	-1.0	-1.0	-0.8
Bipolar Disorder (2018)	0.3	0.4	1.2	1.1	1.0	-0.7	-0.1	0.6	-0.1	0.5	0.5	0.3	0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	-0.8	0.1	-0.1	0.7	0.2	1.1	0.7	0.6	-0.6	0.9
Crohns Disease (2012)	0.3	0.4	1.7	1.3	0.2	0.7	0.4	-1.0	-0.4	-0.6	-0.5	0.4	-0.0
HDL Cholesterol	0.3	0.5	1.1	1.0	0.7	0.1	0.3	0.5	-0.8	0.9	0.9	-0.0	1.1
Triglycerides	0.3	0.6	2.2	-0.4	-0.4	-1.5	-0.3	-0.3	-0.3	-0.5	-0.5	-0.4	-1.5
Ulcerative Colitis	0.3	0.4	1.1	1.0	0.1	-0.6	-0.1	-0.9	-0.2	-0.9	-0.7	0.1	-0.6
Blood Red Count	0.3	2.6	7.0	-0.3	2.0	0.7	2.6	0.9	1.9	1.4	1.1	-2.5	0.8
Hearing difficulty/problems: Yes	0.3	0.5	1.7	-0.8	-0.9	-1.3	0.5	-0.0	0.2	-0.3	-0.4	-1.3	-0.2
Medication: Co-codamol	0.3	0.4	1.5	1.2	1.0	0.1	0.8	-0.2	-0.6	0.2	0.0	-0.5	0.2
Maternal smoking around birth	0.3	0.5	1.6	-1.0	-1.2	-0.8	-0.0	0.2	-0.2	-0.3	-0.0	1.3	-0.0
Age when periods started (menarche)	0.3	0.8	1.8	-1.0	-0.5	-0.9	-1.4	-0.6	0.0	-0.8	-0.9	0.9	-1.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.2	-0.0	-0.3	1.1	-0.7	0.4	0.9	-0.3	-0.1	1.1	0.2
High blood pressure	0.3	0.7	1.8	0.7	0.2	0.7	-0.4	-1.3	-1.0	-1.3	-1.3	0.2	-0.2
Stomach or abdominal pain in last month	0.3	0.3	1.3	0.9	0.1	-0.6	-0.4	0.2	-0.4	-0.1	0.2	1.2	0.6
Supplements: Glucosamine	0.3	0.4	2.1	0.4	-0.2	-0.1	-0.9	-0.0	-0.9	-0.5	-0.2	1.5	0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	2.2	-0.0	0.5	-0.0	0.4	-0.4	-0.2	-0.5	-0.7	-1.5	-0.6
Allergy	0.3	0.6	1.5	-0.0	-0.0	-1.0	-0.7	-0.7	-1.2	-0.7	-0.7	0.3	-1.2
Pain all over the body in last month	0.3	0.3	1.3	0.1	-0.2	0.9	-0.3	0.4	0.2	0.1	0.4	1.2	0.4
Medication: Ramipril	0.3	0.4	1.3	0.8	0.4	1.1	0.6	0.0	0.1	0.3	0.1	-1.0	0.6
Pulse rate	0.3	0.5	1.4	1.2	0.5	-0.9	-0.3	-0.1	-1.0	-0.2	-0.2	0.3	-0.9
Medication: Cholesterol lowering	0.3	0.5	1.0	0.5	0.6	-1.0	-0.5	0.4	-1.0	0.7	0.7	0.8	0.5
Standing height	0.3	3.0	8.8	2.5	0.6	-2.3	-2.1	-0.3	-2.2	0.0	0.1	3.0	0.0
Glaucoma (self-reported)	0.3	0.4	2.2	0.6	0.3	1.5	0.2	-0.1	-0.2	0.2	0.0	-0.9	0.7
Gout (self-reported)	0.3	0.4	0.9	-0.7	-0.7	-0.1	0.3	0.8	0.7	0.3	0.5	0.5	0.9
Health satisfaction	0.3	0.4	1.7	1.1	0.6	-0.4	-0.4	-0.2	-1.3	-0.1	-0.2	-0.6	-0.3
Eye problems/disorders: None of the above	0.3	0.3	1.3	-0.9	-0.1	-1.2	-0.4	-0.1	-0.6	-0.1	0.0	0.5	-0.5
Medication: Blood pressure	0.3	0.5	1.8	0.5	1.1	1.3	0.5	-0.4	-0.1	0.3	-0.0	-0.9	0.9
Medication: Omeprazole	0.3	0.4	1.4	0.2	-0.4	-0.2	-0.9	0.2	0.3	-0.1	0.2	1.2	0.9
Heart disease (mother)	0.3	0.4	1.7	-0.7	-0.2	-1.3	0.6	0.2	0.3	0.2	0.0	-1.0	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.3	-1.0	-0.2	0.6	-0.2	-0.0	1.1	-0.1	-0.2	-0.6	0.1
Pulse rate, automated reading	0.3	0.9	3.3	0.9	0.6	-1.8	-0.2	-0.5	-1.6	-0.4	-0.5	0.0	-1.2
Chest pain or discomfort	0.3	0.4	0.8	0.5	0.7	0.4	0.5	0.7	0.5	0.9	0.9	-0.1	0.8
Qualifications: nursing, teaching	0.3	0.4	1.6	-1.2	-0.8	-0.4	-0.5	0.0	-0.2	-0.3	-0.4	-0.8	-0.7
Medication: Aspirin	0.3	0.4	1.5	1.2	1.0	0.6	-0.1	0.3	-0.2	0.7	0.6	-0.1	0.6
Medication: Gliclazide	0.3	0.3	1.7	1.3	1.0	-0.1	-0.3	-0.1	0.4	0.3	0.3	0.1	0.2
Illnesses of father: None of the above (group 1)	0.3	0.3	1.1	0.6	-0.1	1.0	-1.0	0.0	-0.1	-0.2	0.0	0.8	-0.3
Number of self-reported non-cancer illnesses	0.3	0.5	2.0	1.4	0.3	0.8	-0.7	-0.8	-0.2	-0.7	-0.7	0.2	0.2
Miserableness	0.3	0.5	1.9	-1.0	-0.3	-1.4	0.4	0.8	0.4	0.4	0.5	0.7	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.6	0.8	-0.1	0.7	-0.4	-0.1	0.3	0.0	0.2	1.2	1.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.6	-0.3	0.5	0.6	0.2	0.9	0.2	0.1	-0.9	0.8
Irritable Bowel Disease (IBD)	0.2	0.6	1.8	1.3	0.6	0.8	0.2	-0.9	-0.5	-0.8	-0.8	-0.3	-0.5
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.8	0.1	-0.8	-0.1	-0.7	-0.8	-0.7	-0.6	0.1	-0.6
Breast Cancer	0.2	0.5	1.6	-0.3	1.1	-0.9	0.5	0.9	-0.1	0.6	0.4	-1.3	-0.4
Coronary Artery Disease (CAD)	0.2	0.3	0.9	0.6	0.2	0.6	-0.4	-1.0	-0.3	-0.6	-0.5	0.2	-0.1
Blood Eosinophil Count	0.2	1.3	6.0	-2.5	-2.2	-0.4	-0.5	-0.4	0.0	-0.8	-0.7	0.1	-0.3
Height	0.2	3.4	15.1	3.9	1.3	-3.0	-0.7	-0.4	-2.6	0.2	0.2	1.1	0.2
Smoking Status	0.2	0.5	1.4	0.8	0.5	0.5	-0.7	-0.9	-1.2	-0.3	-0.6	-0.0	-0.5
Diabetes (father)	0.2	0.2	0.6	0.4	0.8	-0.2	0.7	-0.2	0.3	0.0	-0.2	-0.8	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.8	-0.1	-0.9	0.1	-0.4	0.7	0.6	0.4	0.6	1.3	0.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	-0.6	-0.2	0.2	-0.0	-0.6	-0.4	-0.3	-0.2	0.9	0.0
Alcohol usually taken with meals	0.2	0.3	1.4	0.1	-0.2	-1.2	0.6	-0.2	0.1	0.3	0.0	-0.8	0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.4	0.3	-0.7	0.0	0.2	0.0	0.2	-0.3	-0.1	1.2	-0.0
Asthma	0.2	0.3	0.9	-0.5	-0.0	0.8	0.9	0.1	0.4	-0.0	-0.1	-0.9	0.5
Depression (self-reported)	0.2	0.2	0.6	-0.8	0.2	-0.3	0.1	0.6	0.3	0.2	0.1	-0.7	-0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.1	-0.1	-1.0	-0.3	-0.0	0.3	0.9	-0.3	0.0	1.0	-0.2
High blood pressure (siblings)	0.2	0.2	0.9	-0.5	0.5	0.5	-0.3	0.1	-0.7	0.1	-0.2	-1.0	-0.2
Overall health rating	0.2	0.4	1.6	-0.1	0.0	0.1	1.2	0.3	0.5	0.3	0.3	-1.3	0.3
Age at last live birth	0.2	0.3	1.3	-0.4	-0.0	1.1	0.1	0.2	0.7	0.2	0.2	-1.1	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	0.9	-0.3	-0.1	-0.2	0.4	0.1	0.3	0.3	0.9	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.6	0.5	-0.1	-1.3	-0.4	-0.1	-1.0	0.3	0.2	1.2	-0.1
Asthma (self-reported)	0.2	0.5	1.3	-0.8	-0.2	1.0	1.1	0.2	0.7	0.1	0.1	-0.9	0.6
Medication: Bendroflumethiazide	0.2	0.3	1.1	-0.0	0.1	-0.5	0.0	-1.1	-0.2	-0.9	-0.9	-0.1	-0.4
Illnesses of father: High blood pressure	0.2	0.3	0.9	0.5	0.6	0.4	0.0	0.5	-0.2	0.5	0.5	0.7	1.0
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.6	-1.2	-0.7	-0.8	0.2	0.8	0.7	0.8	0.8	-0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	2.0	1.0	0.2	-0.0	0.2	0.3	1.4	-0.2	-0.0	0.1	-0.3
Depression (Nagel 2018)	0.1	0.2	0.3	0.4	-0.4	-0.5	0.1	-0.4	-0.6	-0.3	-0.4	-0.3	-0.4
Blood Platelet Count	0.1	1.5	3.4	-1.9	-0.4	-1.8	-0.9	-0.9	-0.7	-0.7	-1.1	-1.6	-1.3
Hair Pigment	0.1	3.0	5.1	-1.6	-0.1	0.6	2.0	2.0	2.1	2.1	2.0	-1.2	2.3
Sitting height	0.1	0.9	4.0	0.4	-0.4	-1.5	-1.2	0.2	-0.7	-0.2	-0.0	2.0	0.0
Father’s age at death	0.1	0.1	0.3	-0.6	-0.4	-0.4	-0.3	-0.5	-0.0	-0.3	-0.3	-0.3	-0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.1	0.2	-0.2	-0.1	-0.4	0.2	-0.3	-0.5	0.2	-0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	0.4	0.4	0.8	0.3	0.1	0.1	0.4	0.2	-0.6	-0.1
Worry too long after embarrassment	0.1	0.1	0.6	-0.3	-0.0	-0.3	0.7	-0.1	-0.5	0.1	-0.0	-0.1	0.0
Pulse wave peak to peak time	0.1	0.1	0.2	0.5	-0.2	0.1	0.0	0.3	-0.3	0.2	0.5	-0.0	0.1
Comparative height size at age 10	0.1	0.5	2.2	0.7	0.1	-1.5	-0.6	-0.1	-1.1	0.2	0.3	0.7	0.4
Hypertension (Self-reported)	0.1	0.4	0.8	0.7	0.4	0.9	0.2	-0.8	-0.5	-0.9	-0.9	-0.1	0.1
Long-standing illness, disability or infirmity	0.1	0.1	0.4	0.6	0.7	-0.1	0.2	-0.2	-0.3	0.3	0.1	-0.7	0.0
Ever smoked	0.1	0.2	0.6	0.7	0.4	-0.4	0.6	0.0	-0.4	0.5	0.4	-0.0	0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

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