Hub : Genes

DNAH17

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1087	0.0326	5.6e-04	0.008	0.016	0.006	0.016	0.003	0.0280	2.9e-03	0.04700	0.0028	0.14000
2	TCGA	Breast Invasive Carcinoma	0.0407	0.0154	2.1e-05	0.012	0.023	0.015	NA	0.013	0.0011	1.2e-05	0.00033	NA	0.00097
3	TCGA	Lung Adenocarcinoma	0.0721	0.0311	1.3e-03	0.001	0.020	0.021	NA	0.002	0.2000	1.8e-03	0.00150	NA	0.16000
4	TCGA	Pheochromocytoma and Paraganglioma	0.1350	0.0590	8.2e-03	0.040	0.038	0.028	NA	0.016	0.0100	1.2e-02	0.02700	NA	0.07500

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	1.7	1.3	-1.3	0.9	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	1.4	1.0	-0.5	0.5	1.2
Depressed Affect (Nagel 2018)	2.4	5.1	8.1	-2.4	-2.4	-1.1	-2.8
Depression (Nagel 2018)	3.4	5.0	12.4	0.7	-3.5	1.4	-2.3
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.8	1.1	-1.1	0.3	-2.2
Neuroticism (Nagel 2018)	2.0	4.8	9.1	-0.3	-3.0	-1.8	-2.6
Schizophrenia (2018)	0.4	0.8	3.1	0.1	0.4	-0.1	1.7
Schizophrenia vs Biploar Disorder	2.1	2.8	8.8	-3.0	-0.2	1.4	0.5
Worry (Nagel 2018)	1.4	3.0	5.1	0.6	-2.2	-2.2	-1.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.9	-0.4	-0.7	-0.5	-1.4
Alzheimer’s Disease (in father)	2.8	3.1	7.8	-0.8	1.8	-2.8	0.8
Alzheimer’s Disease (including proxy)	0.7	1.0	3.2	-0.6	-0.3	-1.8	-0.7
Crohns Disease (2017)	0.5	1.1	2.3	-1.3	-0.1	0.5	1.5
Irritable Bowel Disease (IBD)	0.4	1.0	2.0	-0.6	-1.2	1.4	0.3
Ulcerative Colitis (UC)	0.8	1.5	2.6	1.0	-1.4	1.6	-0.5
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.4	0.8	1.4	-0.6	1.2	-1.1	0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.5	0.6	-1.6	0.7	-1.4
Breast Cancer	2.0	4.9	12.1	3.5	2.1	0.1	1.8
Ovarian Cancer	0.3	0.4	1.4	-1.2	0.1	-0.0	0.6
Prostate Cancer	0.7	0.9	3.1	-0.1	-0.8	0.1	-1.8
Age at First Birth	0.9	1.3	2.4	-0.6	0.9	1.2	1.6
Bipolar Disorder (2011)	1.1	1.1	4.0	0.0	0.4	0.4	2.0
Body Mass Index (BMI) (2010)	1.7	2.3	5.3	-0.2	1.9	-2.3	-0.7
Coronary Artery Disease (CAD)	0.4	0.4	1.3	1.2	-0.3	-0.5	-0.2
Crohns Disease (2012)	1.2	2.0	4.8	-1.0	-0.4	1.4	2.2
Mean Putamen Volume	1.1	1.3	3.4	-0.8	1.8	-0.3	0.9
Fasting Glucose	0.3	0.3	0.5	-0.5	-0.7	0.5	-0.5
HbA1C	0.8	0.9	2.9	1.7	-0.6	0.0	0.4
HDL Cholesterol	4.1	6.9	13.6	1.2	-3.7	3.5	-0.0
LDL Cholesterol	0.1	0.2	0.8	-0.0	-0.3	0.9	0.2
Lupus	0.6	0.9	2.0	1.2	-0.2	1.4	-0.1
Neuroticism (2016)	0.4	0.6	1.5	0.0	-1.2	-0.8	-0.1
Primary Biliary Cirrhosis	1.3	1.8	3.4	1.8	-1.3	1.4	-0.6
Rheumatoid Arthritis	2.0	2.7	6.4	2.5	0.7	1.1	1.7
Schizophrenia (2014)	0.4	0.8	2.1	1.1	-0.2	-0.2	1.5
Triglycerides	1.0	1.6	3.5	0.3	1.7	-1.9	0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.9	0.4	1.0	0.4	0.6
Ulcerative Colitis	0.7	1.0	3.6	-0.0	-1.9	0.6	-0.0
Blood Eosinophil Count	0.8	6.2	13.2	1.6	-1.2	2.8	3.6
Blood Platelet Count	0.4	4.3	10.2	-0.9	3.2	-2.1	-1.2
Blood Red Count	0.8	7.4	20.3	-1.9	4.5	-1.0	2.1
Blood White Count	0.5	3.5	7.7	-0.7	2.8	1.6	1.8
Heel T-Score	2.7	21.7	48.6	-4.4	7.0	-4.0	1.5
BMI	0.8	4.7	6.8	1.9	2.6	-2.0	-2.1
Height	0.5	10.2	20.4	-0.2	-2.0	4.5	4.0
Waist Hip Ratio (WHR)	4.1	18.2	42.9	1.2	5.3	0.5	6.5
Systolic Blood Pressure	0.5	2.6	5.4	2.3	1.1	1.4	1.3
Smoking Status	0.9	2.2	2.8	-1.4	1.7	1.1	1.6
Allergy or Eczema	1.4	3.7	10.0	1.8	-3.2	0.5	-1.1
Cardiovascular Disease	1.1	3.7	7.5	0.1	1.5	2.3	2.7
Hypothyroidism (self reported)	0.4	0.9	2.7	-0.4	-0.7	1.6	-0.5
Respiratory disease	0.2	0.5	1.0	-1.0	-0.3	0.9	0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.4	-0.2	1.2	-0.6	-1.0
Lung FEV1/FVC ratio	0.6	2.9	4.8	1.5	2.2	-0.1	2.2
Lung FVC	0.2	0.9	3.5	-0.0	-0.1	-1.9	-0.1
Neuroticism	1.7	4.0	7.8	-0.5	-2.8	-2.1	-1.8
Chronotype (morning person)	0.2	0.4	0.6	0.7	0.6	-0.7	0.5
Hair Pigment	0.1	1.7	3.6	-1.9	1.6	-0.1	0.9
Tanning	0.1	1.6	3.7	0.8	1.5	0.1	1.9
Hand grip strength (left)	0.5	1.4	3.6	1.9	-0.6	1.1	0.5
Number of treatments/medications taken	0.0	0.0	0.1	-0.1	0.2	-0.4	0.1
Average weekly spirits intake	0.3	0.4	0.6	-0.8	0.8	-0.5	-0.4
Sensitivity / hurt feelings	0.6	1.1	2.6	-0.7	0.1	-1.6	-1.2
Frequency of depressed mood in last 2 weeks	5.6	7.8	20.7	0.6	-4.5	1.3	-2.9
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.5	-0.2	-0.5	0.3
Relative age of first facial hair	0.2	0.4	1.0	-0.5	0.5	0.0	1.0
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	6.1	2.1	-0.5	0.7	2.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.3	1.1	0.6	-0.2	0.9
Ever had hysterectomy (womb removed)	0.5	0.5	1.3	0.6	0.7	-0.2	-1.1
Systolic blood pressure, automated reading	1.3	3.7	9.7	3.1	1.6	0.9	1.2
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.0	-0.4	-1.0	-0.7	-2.0
Angina	1.6	2.2	5.4	2.3	0.6	-1.4	0.9
Medication for hormone replacement therapy	0.2	0.2	0.7	0.9	-0.2	-0.3	-0.3
Vitamin and mineral supplements	0.8	1.1	3.1	0.4	0.5	-1.8	-0.8
Supplements: Zinc	2.2	2.4	3.8	-1.3	-1.6	-1.2	-2.0
Medication: Co-codamol	1.6	1.8	5.6	-0.9	0.8	2.4	-0.2
Medication: Metformin	0.4	0.6	1.0	-0.1	1.0	-1.0	-0.7
Diabetes (father)	2.1	2.6	8.5	-0.9	0.7	0.8	-2.9
Diabetes (mother)	0.7	0.9	2.0	-0.9	0.8	0.3	1.4
Severe depression (siblings)	0.5	0.5	1.1	0.6	0.7	-1.1	0.4
Pack years adult smoking proportion	0.4	0.6	1.1	-0.7	0.2	-1.0	-0.8
Impedance of leg (right)	0.8	3.8	7.6	-2.3	-1.0	2.8	1.3
Leg fat-free mass (left)	0.2	0.9	3.4	1.8	0.3	0.0	-0.2
Trunk fat percentage	0.4	1.6	4.9	-0.5	2.2	-0.8	-0.8
Hand grip strength (right)	0.5	1.2	4.8	2.2	-0.3	0.1	-0.1
Townsend deprivation index at recruitment	0.7	0.9	2.9	-0.7	-0.0	1.7	0.7
Current tobacco smoking	0.1	0.1	0.3	-0.2	0.3	0.3	0.5
Average weekly fortified wine intake	0.7	0.8	1.3	-1.1	0.7	-0.6	1.1
Maternal smoking around birth	0.5	0.7	2.2	-0.6	-0.2	-1.5	0.3
Fed-up feelings	3.1	5.7	9.5	-1.9	-1.7	-2.6	-3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.5	1.2	-1.1	1.2	-0.7
Relative age voice broke	0.5	0.8	2.5	-0.6	-0.2	0.5	1.6
Taking other prescription medications	1.2	1.8	3.7	1.4	-1.1	-1.9	0.6
Age when periods started (menarche)	0.9	2.1	4.5	-0.0	-2.1	1.8	0.6
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.1	1.3	1.1	-0.8	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.1	19.6	-4.4	1.9	-1.1	-0.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	0.9	-0.2	-0.9	-0.7	-0.9
Qualifications: CSEs or equivalent	0.2	0.3	0.5	-0.0	0.7	0.6	0.5
Serious illness, injury or assault to yourself	0.5	0.6	1.0	1.0	-0.6	-0.5	0.9
High blood pressure	1.0	2.9	5.6	0.3	1.8	1.6	2.4
Hayfever, allergic rhinitis or eczema	1.3	2.8	8.2	1.3	-2.9	0.2	-1.1
Multivitamins +/- minerals	1.3	1.7	4.8	-0.9	-0.8	2.2	0.6
Stomach or abdominal pain in last month	1.0	1.2	4.3	0.2	-0.5	-2.1	-0.5
Supplements: Glucosamine	0.5	0.7	1.8	0.3	-1.0	1.3	-0.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.9	0.3	1.4	-1.0	0.1
Medication: Atenolol	0.7	0.9	2.8	0.3	1.7	0.3	0.7
Medication: Levothyroxine sodium	0.0	0.1	0.2	0.1	0.1	0.5	0.2
Sitting height	0.2	1.2	3.2	-0.7	-1.1	1.8	-0.2
Chronic bronchitis/emphysema (father)	0.6	0.6	2.6	-0.1	1.6	0.0	-0.0
High blood pressure (mother)	1.7	2.3	4.0	2.0	-0.1	-1.5	-1.7
Body mass index (BMI)	0.8	3.6	6.0	1.4	2.4	-1.9	-1.6
Impedance of leg (left)	0.9	4.6	8.2	-2.7	-0.1	2.9	1.7
Leg predicted mass (left)	0.2	0.9	3.6	1.9	0.2	0.0	-0.3
Trunk fat mass	0.3	1.1	4.1	0.1	2.0	-0.4	-0.5
Waist circumference	1.1	4.2	10.0	2.3	3.2	-1.0	0.7
Number of incorrect matches in round	0.3	0.4	0.6	0.7	0.2	-0.7	0.8
Past tobacco smoking	0.1	0.2	0.6	-0.8	0.2	-0.3	0.2
Alcohol usually taken with meals	0.1	0.1	0.4	-0.3	-0.6	-0.1	0.3
Nervous feelings	1.1	2.0	6.8	1.2	-0.2	-2.6	0.0
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.9	5.9	1.2	-2.4	-0.5	-1.9
Hearing difficulty/problems with background noise	1.0	1.6	2.1	0.6	-1.5	-1.3	-1.4
Hair/balding pattern: Pattern 2	0.5	0.7	1.3	0.5	0.8	0.7	1.1
Had menopause	0.4	0.5	1.0	0.5	0.7	0.6	1.0
Had other major operations	2.1	2.5	7.4	-2.7	1.3	-0.5	0.9
Forced vital capacity (FVC)	0.2	0.9	3.0	-0.2	-1.7	0.8	0.0
Heel bone mineral density (BMD) T-score, automated (right)	3.2	7.4	13.5	-3.6	3.7	-1.5	0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.4	0.0	0.3	-1.6	-0.5
Qualifications: None of the above	0.3	0.5	1.3	-0.2	1.1	-0.5	-0.7
Financial difficulties in last 2 years	0.5	0.7	1.7	0.5	-1.3	0.1	-1.0
Mouth/teeth dental problems	1.4	2.1	4.2	-0.5	-1.9	2.1	-0.7
Heart attack	0.8	1.0	3.7	-0.1	0.6	-1.9	0.2
Allergy	0.6	1.5	2.9	-1.7	1.7	-0.2	0.4
Pain all over the body in last month	0.2	0.2	0.6	0.8	-0.0	0.5	0.1
Diabetes (self-reported)	0.9	1.4	3.5	-1.0	0.5	-0.8	-1.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	-0.9	-0.4	0.5	0.1
Medication: Ramipril	0.7	0.9	2.7	-0.6	-1.6	0.5	-0.5
Medication: Simvastatin	0.2	0.3	0.7	-0.2	0.8	0.6	0.4
Fluid intelligence score	0.4	0.9	1.7	-0.5	-1.2	-0.0	-1.3
Illnesses of siblings	0.3	0.5	1.2	0.3	-1.1	0.1	0.8
Neuroticism score	1.7	3.5	5.3	-0.6	-2.1	-2.3	-2.0
Weight	0.2	1.0	2.2	1.4	1.5	0.1	-0.3
Impedance of arm (right)	1.0	4.6	8.6	-2.9	-2.8	1.2	-0.4
Arm fat percentage (right)	0.6	2.5	5.1	0.3	1.3	-1.8	-2.3
Trunk fat-free mass	0.3	1.6	3.0	1.7	0.0	1.6	0.8
Hip circumference	0.4	1.6	4.6	1.0	0.4	-0.8	-2.1
Time employed in main current job	1.5	1.8	3.0	0.8	0.9	1.7	1.6
Alcohol intake versus 10 years previously	0.9	1.4	2.5	1.6	-1.6	-0.6	-0.4
Father’s age at death	1.3	1.8	5.7	1.1	-0.0	-2.4	-0.4
Worrier / anxious feelings	0.7	1.3	2.0	0.7	-1.4	-1.0	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.3	-0.3	-0.5	-0.7
Falls in the last year	0.4	0.5	1.0	-1.0	0.3	0.9	-0.4
Hair/balding pattern: Pattern 3	0.7	1.1	2.8	-0.8	-0.7	1.7	0.7
Number of live births	2.3	3.3	7.8	0.8	2.2	-0.4	2.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.8	-0.4	-0.9	0.9	0.3
Pulse rate	0.3	0.5	0.9	0.2	0.6	-0.9	0.8
Happiness	0.1	0.1	0.2	0.5	0.1	0.5	0.0
Noisy workplace	1.1	1.4	2.9	1.4	-1.7	-0.3	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.5	0.2	-1.9	-0.2	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.2	-0.4	-0.8	-1.5	-0.4
Mouth/teeth dental problems: Dentures	1.0	1.6	3.9	1.0	0.9	-2.0	0.9
Asthma	0.1	0.2	0.3	0.5	0.3	-0.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	4.9	1.4	1.2	-2.2	-0.5
Medication: Cholesterol lowering	0.8	1.2	3.7	-0.9	-0.4	-1.9	-0.1
Depression (self-reported)	0.7	0.8	1.0	0.7	0.8	-1.0	1.0
Medication: Lansoprazole	1.4	1.6	3.6	-0.3	1.9	-1.0	1.3
Prospective memory result	0.4	0.5	1.0	1.0	0.2	0.9	0.6
Lung cancer (father)	0.6	0.7	1.4	-1.2	0.5	0.6	-0.8
Illnesses of mother	0.9	1.1	3.1	-0.6	0.6	1.8	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	-1.1	-0.7	0.2	0.4
Pulse wave Arterial Stiffness index	1.4	1.6	4.0	0.8	0.5	1.2	2.0
Impedance of arm (left)	0.8	3.9	9.6	-3.1	-2.2	1.1	0.2
Arm fat mass (right)	0.4	1.6	3.0	0.9	1.7	-1.1	-1.1
Trunk predicted mass	0.3	1.4	2.8	1.7	-0.1	1.6	0.7
Standing height	0.7	7.0	16.3	0.1	-1.4	4.0	3.1
Length of working week for main job	1.6	1.8	4.0	-0.7	2.0	0.3	1.6
Exposure to tobacco smoke at home	0.2	0.3	0.9	0.1	-0.3	0.3	1.0
Breastfed as a baby	0.3	0.3	0.9	1.0	-0.4	-0.1	0.5
Tense / ‘highly strung’	0.9	1.6	5.6	0.0	-0.5	-2.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	3.1	1.4	1.8	-1.3	1.5
Hair/balding pattern: Pattern 4	0.6	1.5	4.4	2.1	1.3	0.3	0.2
Birth weight of first child	0.4	0.8	1.8	-0.1	0.7	0.9	1.3
Peak expiratory flow (PEF)	0.5	1.2	3.6	-1.9	-0.5	1.0	0.0
Pulse wave reflection index	2.0	2.4	8.0	2.8	-0.3	0.1	1.3
Ever highly irritable/argumentative for 2 days	1.0	1.3	2.5	0.1	-0.4	-1.6	-1.5
Loud music exposure frequency	0.4	0.5	0.7	0.5	-0.7	-0.8	-0.6
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.7	-1.3	-1.9	1.2	-0.4
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.6	-0.2	1.9	1.1	1.5
Blood clot in the leg (DVT)	1.7	2.2	5.0	0.6	1.8	-0.6	2.2
Medication: Paracetamol	0.5	0.8	1.7	-0.7	1.0	-1.3	-0.3
Headache pain in last month	1.5	2.6	9.6	-0.2	0.9	-3.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.2	1.1	0.1	0.6	-0.4
Glaucoma (self-reported)	0.1	0.1	0.2	0.3	-0.1	0.4	0.1
Gout (self-reported)	0.8	1.1	2.7	-0.8	-0.1	-0.9	-1.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.5	-0.0	-0.3	1.6	0.4
Medication: Amlodipine	0.6	0.9	2.7	0.9	0.0	1.6	-0.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	-0.3	-0.5	-1.1	-0.2
Birth weight	1.1	2.3	3.8	-1.4	2.0	-0.2	1.9
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.9	-2.0	-0.3	-0.8	0.4
High blood pressure (siblings)	0.8	1.1	2.9	-0.4	0.9	-0.9	-1.7
Forced vital capacity (FVC), Best measure	0.4	1.3	3.2	-1.3	-1.8	0.3	-0.4
Body fat percentage	0.4	1.7	4.7	-0.1	2.2	-0.8	-1.1
Leg fat percentage (right)	0.4	1.3	3.4	0.4	1.9	-0.2	-1.3
Arm fat-free mass (right)	0.5	2.4	4.4	2.1	1.4	1.5	1.1
Exposure to tobacco smoke outside home	1.6	2.1	6.0	-0.6	-1.4	2.5	-0.2
Comparative body size at age 10	1.1	3.1	10.3	3.2	-0.0	-1.2	0.7
Number of full brothers	1.3	1.6	4.0	-1.2	2.0	-0.7	0.7
Worry too long after embarrassment	1.2	1.9	3.0	0.7	-1.7	-1.7	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.3	-0.0	-0.1	-0.1	1.2
Wheeze or whistling in the chest in last year	0.2	0.4	0.6	-0.6	0.5	-0.8	0.3
Number of children fathered	0.4	0.5	1.3	-0.2	0.7	-1.1	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	1.0	0.6	0.1	-0.3
Age at first live birth	0.9	1.6	4.9	0.4	-2.2	1.1	-0.3
Pulse wave peak to peak time	1.1	1.3	3.4	-0.9	-0.6	-0.8	-1.8
Health satisfaction	0.2	0.3	0.9	1.0	-0.5	-0.1	-0.2
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.2	-0.9	0.0	-0.8
Qualifications: College or University degree	0.2	0.8	1.7	0.9	-0.7	1.3	0.2
Eye problems/disorders: None of the above	0.5	0.6	1.8	-0.6	0.2	1.4	-0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.5	-0.6	0.7	-0.6	-0.3
Emphysema/chronic bronchitis	1.1	1.3	3.4	-1.8	0.3	1.3	-0.1
Medication for pain relief, constipation, heartburn	0.9	1.6	3.9	-0.6	-1.4	2.0	-0.3
Neck or shoulder pain in last month	0.5	0.7	2.3	-0.3	0.6	-1.5	-0.0
Medication: Blood pressure	0.3	0.6	1.5	-0.7	0.4	-0.4	1.2
Angina (self-reported)	1.9	2.5	5.7	2.4	0.7	-1.8	0.8
Migraine (self-reported)	0.7	0.9	1.3	-1.1	0.5	-1.0	1.1
Medication: Ibuprofen	1.2	1.5	3.6	-0.2	1.5	-1.9	-0.2
Medication: Allopurinol	0.4	0.5	1.2	-1.1	0.7	-0.5	-0.0
Medication: Omeprazole	0.2	0.2	0.3	-0.4	0.1	-0.5	-0.5
Medication: Seretide 50 evohaler	2.2	2.5	7.5	-1.5	2.7	-0.1	0.6
Mean time to correctly identify matches	0.4	0.8	1.7	-0.4	1.3	-0.9	0.8
Heart disease (mother)	0.2	0.2	0.6	0.1	0.8	0.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.7	-0.6	-0.9	-1.6	-1.2
Whole body fat mass	0.3	1.3	4.2	0.6	2.1	-0.7	-0.6
Leg fat mass (right)	0.3	1.3	2.5	1.1	1.6	-0.4	-1.2
Arm predicted mass (right)	0.5	2.4	5.1	2.2	1.5	1.2	1.0
Pulse rate, automated reading	0.0	0.1	0.2	0.5	0.0	-0.3	-0.1
Alcohol intake frequency.	0.8	1.9	3.5	1.4	-1.1	-1.9	-0.9
Comparative height size at age 10	0.4	2.2	5.3	0.8	-1.1	1.2	2.3
Number of full sisters	1.1	1.3	2.6	-1.6	-0.4	1.4	-0.8
Suffer from ‘nerves’	0.7	1.1	2.1	1.1	-1.5	-0.9	0.3
Overall health rating	0.7	1.5	3.6	1.9	-0.9	0.7	-1.1
Chest pain or discomfort	0.7	1.1	1.9	-1.3	1.4	-0.6	0.6
Had major operations	0.3	0.4	0.8	0.4	-0.9	0.5	-0.6
Age at last live birth	0.4	0.6	2.5	0.0	-1.6	0.2	-0.2
Family relationship satisfaction	0.9	1.1	3.3	1.8	0.5	0.4	0.9
Leg pain on walking	0.7	0.9	1.8	1.4	-1.1	-0.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.3	-0.5	0.9	1.0	2.1
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.2	1.8	-0.7	-0.2	-0.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.6	-0.8	-0.0	1.9	0.4
Medication: Aspirin	0.1	0.1	0.3	0.1	0.0	-0.5	0.4
Supplements: Vitamin C	0.2	0.3	0.5	0.3	-0.6	-0.7	-0.4
Knee pain experienced in last month	0.2	0.4	0.6	0.4	-0.7	-0.5	-0.8
Hypertension (Self-reported)	0.9	2.5	4.4	0.5	1.7	1.6	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	3.2	-1.5	1.8	-1.2	0.2
Illnesses of father: Heart disease	0.2	0.3	1.0	-1.0	-0.3	0.2	-0.0
Illnesses of siblings: Diabetes	0.5	0.6	1.9	1.4	0.6	-0.1	-0.0
Smoking status: Previous	0.2	0.3	0.5	0.7	-0.0	0.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.5	-1.2	-1.9	1.3	-0.0
Whole body fat-free mass	0.2	1.3	3.6	1.9	0.3	1.1	0.4
Leg fat-free mass (right)	0.2	0.8	2.9	1.7	0.6	0.1	0.0
Arm fat percentage (left)	0.6	2.4	4.1	0.1	1.7	-1.7	-2.0
Average weekly red wine intake	0.9	1.4	3.3	-0.6	-1.8	1.4	0.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	0.7	0.7	-1.1	-0.5
Mood swings	1.1	2.1	4.0	0.2	-2.0	0.6	-2.0
Loneliness, isolation	1.7	2.4	5.5	-1.7	-0.8	-0.8	-2.4
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.8	-0.3	0.4	-0.1
Ever had bowel cancer screening	1.1	1.3	2.5	1.6	-1.6	-0.3	-0.0
Diabetes diagnosed by doctor	0.7	1.1	2.5	-0.7	0.7	-1.0	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	7.7	-1.2	2.8	-0.7	0.8
Friendships satisfaction	0.4	0.4	1.0	-0.3	-0.8	1.0	-0.3
Qualifications: nursing, teaching	0.7	1.0	2.9	-1.7	-0.5	-0.3	0.9
Commuting to job workplace: Walk	0.9	1.0	3.7	-1.9	-0.3	0.5	0.1
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.6	-0.2	-0.6	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.0	-1.7	0.1	-1.0	-1.3
Medication for cholesterol	0.2	0.2	0.6	-0.5	-0.7	0.2	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.9	1.0	-0.8	-1.4	-0.9
Back pain experienced in last month	0.5	0.7	2.1	0.2	0.3	-1.5	-0.6
Mineral and other dietary supplements	1.5	2.0	5.2	1.1	1.1	-2.3	-0.6
Breast cancer (self-reported)	0.3	0.3	0.7	0.8	0.3	0.1	0.7
Asthma (self-reported)	0.1	0.2	0.3	0.5	0.3	-0.5	0.5
Osteoporosis (self-reported)	1.4	1.7	4.2	2.1	-0.4	0.2	1.6
Osteoarthritis (self-reported)	0.8	1.0	2.5	1.6	0.4	0.1	1.2
Medication: Aspirin	0.1	0.2	0.3	0.1	0.2	-0.5	0.6
Medication: Gliclazide	1.9	2.1	3.4	-1.8	-1.4	-1.1	-1.3
Illnesses of father: None of the above (group 1)	1.5	1.8	3.8	1.1	0.4	1.4	2.0
Smoking status: Current	0.1	0.2	0.3	-0.2	0.5	0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	-1.1	0.4	0.3	0.4
Whole body water mass	0.2	1.3	4.0	2.0	0.2	1.1	0.4
Leg predicted mass (right)	0.1	0.8	2.8	1.7	0.5	0.1	-0.1
Arm fat mass (left)	0.4	1.6	4.0	0.7	2.0	-1.1	-0.9
Number of self-reported non-cancer illnesses	0.6	1.1	2.1	1.2	0.5	0.7	1.4
Average weekly champagne plus white wine intake	0.5	0.6	1.9	-0.7	-0.2	-1.4	-0.3
Miserableness	1.1	2.0	3.0	-1.7	-1.1	-1.7	-1.0
Guilty feelings	0.9	1.3	2.6	-0.1	-1.6	0.4	-1.6
Wears glasses or contact lenses	0.7	0.8	1.3	0.9	-1.1	-1.1	0.2
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.6	-0.1	-0.2	-0.7
Hearing aid user	1.1	1.2	3.0	0.6	1.7	-1.1	0.6
Mother’s age at death	1.0	1.2	2.5	-0.0	-1.6	0.2	-1.5
Financial situation satisfaction	3.7	4.6	10.0	3.2	-1.4	2.5	-0.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.7	0.8	-0.0	-1.3	-0.8
Commuting to job workplace: Public transport	0.6	0.7	1.7	-0.5	0.3	0.9	1.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.3	-1.0	0.6	-0.8
Medication: Blood pressure	0.4	0.7	2.2	0.7	1.5	0.4	-0.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.6	0.6	-0.6	-0.1	-1.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	-0.0	-0.6	1.2	0.4
High cholesterol (Self-reported)	0.1	0.2	0.8	-0.9	-0.3	0.1	-0.0
Medication: Bendroflumethiazide	0.3	0.4	1.4	-0.5	1.2	-0.3	-0.1
Medication: Paracetamol	0.6	1.0	2.2	-1.5	0.5	-1.2	-0.2
Medication: Lisinopril	2.0	2.6	5.7	1.4	1.6	0.3	2.4
Medication: Atorvastatin	1.3	1.6	5.2	0.1	-0.7	-2.3	-0.9
Illnesses of father: High blood pressure	1.4	1.8	3.4	1.5	-0.8	-1.8	-0.9
Alcohol drinker status: Never	0.1	0.2	0.2	-0.1	-0.5	-0.5	-0.5
Ever smoked	0.1	0.1	0.3	0.5	-0.3	0.0	0.1
Basal metabolic rate	0.2	1.0	3.0	1.7	0.6	0.9	0.2
Leg fat percentage (left)	0.6	2.1	7.1	0.3	2.7	-0.5	-1.1
Arm fat-free mass (left)	0.3	1.7	3.1	1.8	1.2	1.3	0.8
Number of operations (self-reported)	0.9	1.3	2.1	-1.4	1.4	-0.6	0.8
Average weekly beer plus cider intake	1.6	2.3	4.1	2.0	-0.7	1.9	-1.0
Irritability	0.9	1.5	3.0	0.5	-0.7	-1.7	-1.5
Risk taking	0.3	0.5	0.9	-0.9	0.3	-0.1	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	0.7	-0.6	-0.7	1.0
Fractured/broken bones in last 5 years	1.9	2.4	6.0	2.5	-0.7	1.4	1.1
Age started oral contraceptive pill	0.6	0.8	1.3	-0.9	1.1	0.0	1.0
Diastolic blood pressure, automated reading	1.5	4.7	13.9	3.7	1.2	1.3	1.3
Ever depressed for a whole week	0.2	0.3	0.9	0.4	0.3	-0.9	-0.1
Unable to work because of sickness or disability	1.0	1.3	4.1	2.0	-1.0	-0.2	0.2
Commuting to job workplace: Cycle	1.2	1.4	2.8	-1.7	-0.9	0.6	-1.3
Myopia	0.7	1.1	2.2	-0.0	1.0	1.5	1.1
Vascular/heart problems diagnosed by doctor	1.3	3.5	7.7	-0.3	-2.3	-1.0	-2.8
Cholesterol lowering medication	0.1	0.1	0.2	0.2	0.4	0.5	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.6	0.7	-0.9	0.1
Pain experienced in last month	0.9	1.6	4.3	-0.8	-1.1	2.1	0.1
Supplements: Calcium	3.8	4.2	9.7	1.5	-1.7	3.1	1.4
Basal cell carcinoma (self-reported)	0.5	0.6	0.9	-0.5	0.7	-1.0	0.9
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.6	-0.5	0.7	-2.1	0.4
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	5.9	0.6	1.7	-0.2	2.4
Heart disease (siblings)	0.1	0.2	0.4	0.6	0.5	0.3	0.0
Alcohol drinker status: Previous	1.5	1.7	2.5	1.6	1.3	-1.3	1.0
Pack years of smoking	0.6	0.9	1.7	-1.1	0.6	-1.3	-0.6
Impedance of whole body	0.9	4.5	12.5	-3.5	-0.9	1.9	1.1
Leg fat mass (left)	0.4	1.6	4.0	1.1	2.0	-0.5	-1.0
Arm predicted mass (left)	0.3	1.5	4.0	2.0	1.0	1.0	0.5