TWAS hub - DNAH5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.4240	0.0450	0.0e+00	0.244	0.308	0.325	0.320	0.330	1.9e-29	4.1e-38	1.6e-40	7.6e-40	3.1e-41
2	ROSMAP	Brain Pre-frontal Cortex	0.1749	0.0341	2.0e-12	0.071	0.111	0.131	0.117	0.128	1.9e-09	4.7e-14	1.9e-16	8.5e-15	3.5e-16
3	TCGA	Breast Invasive Carcinoma	0.0463	0.0155	4.8e-07	0.023	0.039	0.029	NA	0.035	1.5e-05	1.9e-08	1.2e-06	NA	9.7e-08
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0906	0.0332	9.8e-05	0.070	0.039	0.025	NA	0.055	2.5e-08	3.1e-05	7.8e-04	NA	8.2e-07
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0635	0.0289	1.4e-03	0.003	0.032	0.017	NA	0.001	1.3e-01	1.5e-04	4.7e-03	NA	2.5e-01
6	TCGA	Brain Lower Grade Glioma	0.1096	0.0374	1.3e-06	0.013	0.058	0.063	NA	0.052	1.2e-02	3.7e-07	1.2e-07	NA	1.3e-06
7	TCGA	Lung Adenocarcinoma	0.1379	0.0418	5.4e-08	0.041	0.080	0.047	NA	0.059	1.4e-05	1.2e-09	3.2e-06	NA	2.0e-07
8	TCGA	Lung Squamous Cell Carcinoma	0.1124	0.0381	1.4e-06	0.084	0.063	0.085	NA	0.082	7.7e-10	1.1e-07	6.1e-10	NA	1.4e-09
9	TCGA	Pancreatic Adenocarcinoma	0.1830	0.0650	4.8e-04	-0.005	0.081	0.034	NA	-0.002	6.2e-01	2.8e-04	1.4e-02	NA	3.9e-01
10	TCGA	Prostate Adenocarcinoma	0.0810	0.0311	4.0e-05	0.088	0.043	0.057	NA	0.066	1.6e-09	2.3e-05	1.4e-06	NA	2.0e-07
11	TCGA	Rectum Adenocarcinoma	0.3460	0.1050	5.5e-04	0.068	0.220	0.075	NA	0.076	1.1e-02	6.9e-06	8.2e-03	NA	7.6e-03
12	TCGA	Thyroid Carcinoma	0.1430	0.0490	1.4e-06	0.056	0.064	0.084	NA	0.068	3.4e-06	7.9e-07	1.6e-08	NA	3.2e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Lung FEV1/FVC ratio	4.3	21.7	40.8	-3.2	-5.3	-4.4	-6.1	-4.0	-3.2	-3.4	-6.4	-2.5	-6.0	-3.7	-5.6
Gout (self-reported)	4.0	5.4	8.1	2.1	2.0	2.4	2.3	1.6	2.3	2.7	2.8	2.2	2.6	2.5	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.0	8.6	11.5	-3.1	-3.2	-3.4	-2.7	-2.1	-2.7	-2.3	-2.8	-3.2	-3.1	-3.1	-3.1
Medication: Ibuprofen (e.g. Nurofen)	3.1	3.9	7.0	-1.6	-1.2	-2.3	-2.1	-2.0	-2.4	-1.1	-2.6	-1.8	-2.2	-2.1	-1.6
Forced expiratory volume in 1-second (FEV1)	3.0	10.0	13.1	-3.6	-2.9	-3.1	-2.6	-2.4	-3.4	-2.7	-3.5	-3.5	-3.3	-3.4	-3.3
Headache pain in last month	3.0	5.2	8.6	-0.7	-1.7	-2.5	-2.8	-1.7	-2.9	-2.1	-2.9	-2.8	-2.5	-2.1	-1.6
Medication for pain relief, constipation, heartburn	2.9	4.9	8.4	0.7	1.8	2.4	2.2	1.9	2.4	2.4	2.9	2.9	2.5	1.9	1.7
Average weekly red wine intake	2.9	4.3	15.4	-1.6	-1.3	-0.9	-3.9	-0.9	-1.1	-0.3	-3.3	-1.1	-3.5	0.2	-2.2
Pain experienced in last month	2.9	4.8	7.4	1.5	1.6	2.3	2.6	2.2	2.7	1.1	2.6	2.5	2.4	2.3	1.9
Age at First Birth	2.8	4.1	8.0	1.4	2.0	2.4	1.9	0.5	2.8	2.1	2.2	1.7	2.0	2.6	1.7
Hearing difficulty/problems: Yes	2.7	4.1	10.6	-1.3	-1.7	-1.8	-2.1	-1.3	-3.3	-1.1	-1.7	-2.5	-1.9	-2.4	-2.2
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	6.2	-2.5	-1.8	-2.2	-0.7	-0.9	-1.5	-1.0	-1.1	-2.4	-1.2	-1.7	-2.2
Alcohol drinker status: Never	2.5	2.9	6.3	-2.4	-1.4	-2.4	-0.8	-1.8	-1.0	-0.3	-1.0	-2.5	-1.2	-2.4	-1.6
Average weekly beer plus cider intake	2.5	3.6	8.7	-0.3	0.8	2.1	2.4	1.6	2.5	1.4	2.5	0.9	2.2	3.0	0.2
Father’s age at death	2.4	3.2	7.1	-0.9	-1.9	-1.6	-2.7	-1.9	-1.2	-0.9	-2.1	-1.7	-2.4	-1.2	-2.0
Osteoarthritis (self-reported)	2.4	3.1	8.0	-1.1	-1.2	-1.6	-1.5	-0.6	-2.1	-2.2	-2.1	-2.8	-1.8	-1.4	-1.6
Lung FVC	2.3	11.5	16.9	-4.1	-3.6	-3.1	-3.4	-2.7	-3.3	-2.3	-3.6	-3.7	-3.8	-2.5	-4.1
Migraine (self-reported)	2.3	2.9	5.1	-1.4	-1.9	-1.4	-2.0	-0.8	-1.2	-1.7	-1.8	-1.2	-2.1	-2.0	-2.3
Handedness (chirality/laterality): Left-handed	2.3	2.7	7.3	1.1	1.9	1.5	1.7	0.5	1.7	1.7	1.5	2.7	1.6	1.2	1.9
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	4.6	1.9	1.6	1.0	1.8	1.0	1.7	1.2	1.5	2.1	1.9	0.4	1.8
Pulse rate	2.2	3.7	10.9	2.6	1.6	1.6	1.8	1.7	1.9	1.0	1.5	3.3	1.9	1.2	2.0
Pulse wave reflection index	2.2	2.7	6.0	-2.0	-2.3	-1.1	-2.1	-0.2	-0.9	-0.3	-2.2	-0.7	-2.1	-0.9	-2.4
Qualifications: CSEs or equivalent	2.1	2.8	5.5	1.6	1.9	1.7	1.6	2.4	1.1	1.4	1.8	0.9	1.8	1.1	2.1
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	6.2	-0.9	-1.7	-2.0	-2.5	-2.0	-1.3	-0.9	-2.1	-2.1	-2.2	-1.6	-2.0
Financial situation satisfaction	2.1	2.7	5.6	-1.2	-1.9	-1.5	-1.1	-1.2	-1.8	-2.4	-1.7	-0.8	-1.6	-1.2	-2.4
Pack years of smoking	2.1	3.0	5.6	1.4	1.9	1.5	1.6	0.9	1.9	2.4	1.8	1.1	2.0	1.7	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	9.3	-3.0	-2.6	-2.5	-2.0	-1.6	-2.2	-2.1	-2.9	-2.7	-2.7	-2.5	-2.8
Age started oral contraceptive pill	2.0	2.5	8.0	-1.4	-1.1	-2.5	-0.3	-1.9	-1.5	-0.9	-0.8	-1.5	-0.6	-2.8	-1.5
Medication: Omeprazole	1.9	2.3	7.0	-2.0	-0.3	-0.9	-1.0	-0.5	-2.6	-1.2	-1.6	-2.1	-1.4	-1.7	-1.0
Alzheimer’s Disease (including proxy)	1.8	2.7	6.8	1.4	1.7	1.5	2.6	1.9	0.4	0.9	1.8	1.4	2.2	0.4	1.9
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	6.4	-1.3	-2.2	-1.5	-1.2	-2.5	-0.2	-1.0	-1.0	-0.3	-1.1	-1.1	-2.1
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.7	-1.5	-2.2	-1.5	-1.7	-0.1	-1.3	-1.3	-1.2	-1.4	-1.6	-1.8	-1.9
Medication: Ventolin 100micrograms inhaler	1.8	2.3	5.0	0.5	1.5	0.9	2.2	1.1	0.9	1.5	2.1	1.3	2.2	0.3	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	5.2	0.2	2.1	1.2	2.3	0.2	0.6	2.2	1.5	0.7	2.1	1.2	1.8
Neck or shoulder pain in last month	1.8	2.6	7.4	-0.8	-1.0	-1.5	-1.6	-1.1	-2.7	-1.7	-1.7	-2.4	-1.6	-1.1	-1.0
Time employed in main current job	1.7	2.0	2.9	1.4	1.4	1.5	1.5	1.3	1.1	1.4	1.7	1.5	1.5	1.0	1.4
Medication: Ibuprofen	1.7	2.0	4.8	-1.0	-0.4	-1.6	-1.3	-0.8	-2.2	-0.8	-2.0	-1.3	-1.5	-1.9	-1.0
Back pain experienced in last month	1.7	2.6	5.3	-1.8	-1.2	-1.5	-1.4	-2.0	-2.3	-0.9	-1.7	-1.1	-1.5	-1.7	-1.5
Supplements: Fish oil (including cod liver oil)	1.7	2.3	4.1	-1.5	-1.3	-1.8	-1.2	-1.1	-2.0	-1.2	-2.0	-1.2	-1.5	-1.6	-1.3
Unable to work because of sickness or disability	1.7	2.2	4.6	-0.6	-1.5	-2.1	-1.5	-1.0	-1.8	-0.8	-1.8	-1.2	-1.5	-2.1	-0.9
Irritable Bowel Disease (IBD)	1.6	3.8	9.4	-0.2	-1.9	-1.7	-3.1	-1.1	-1.1	-1.9	-2.9	-1.2	-2.8	-1.5	-2.0
Hearing difficulty/problems with background noise	1.6	2.6	7.2	-1.1	-1.3	-1.4	-1.9	-0.8	-2.7	-0.2	-1.5	-1.2	-1.8	-1.8	-2.1
Medication: Paracetamol	1.6	2.6	10.7	0.1	-1.1	-1.9	-1.2	-1.9	-2.0	-1.6	-1.1	-3.3	-0.9	-1.2	-0.7
Osteoporosis (self-reported)	1.6	1.9	3.9	-2.0	-1.5	-1.3	-0.8	-1.2	-1.5	-1.3	-1.4	-1.4	-1.3	-1.4	-1.4
Intelligence (Savage-Jansen 2018)	1.5	4.5	7.3	-1.5	-2.0	-2.4	-2.6	-2.4	-1.8	-0.4	-2.6	-0.7	-2.7	-2.3	-2.5
Fasting Glucose	1.5	1.8	3.6	1.0	1.0	1.9	1.0	1.5	1.5	1.3	1.9	0.1	1.3	1.8	0.8
Severe depression (siblings)	1.5	1.6	3.1	-1.2	-1.2	-1.1	-1.6	-0.7	-1.1	-0.6	-1.8	-1.6	-1.5	-1.3	-1.1
Pack years adult smoking proportion	1.5	2.2	5.0	1.1	1.6	1.3	1.3	1.0	1.5	2.2	1.3	1.0	1.6	1.5	1.9
Ever depressed for a whole week	1.5	1.8	6.8	-1.8	-2.0	-1.5	-0.3	-2.6	-1.2	-0.6	-0.8	-0.5	-0.6	-1.0	-1.4
Ovarian Cancer	1.4	1.9	2.9	-1.7	-1.7	-1.7	-0.9	-1.7	-1.6	-1.2	-0.9	-0.7	-1.0	-1.5	-1.4
LDL Cholesterol	1.4	2.2	3.6	1.0	1.2	1.6	1.7	1.4	0.6	1.3	1.6	1.9	1.8	1.1	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.6	-0.9	-0.9	-1.6	-0.9	-2.2	-2.0	-1.2	-1.2	-1.7	-0.8	-1.4	-0.9
Medication: Ramipril	1.4	1.8	5.6	0.6	1.3	0.8	2.4	0.1	0.7	0.6	1.1	1.9	1.9	0.7	1.9
Worrier / anxious feelings	1.4	2.7	7.4	-2.0	-1.2	-1.2	-0.7	-2.7	-2.4	-1.7	-1.2	-2.1	-1.1	-0.7	-1.2
Peak expiratory flow (PEF)	1.4	3.4	5.6	-1.0	-1.6	-1.6	-1.8	-0.8	-2.1	-1.8	-2.2	-2.4	-2.0	-2.1	-2.0
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	4.0	-1.5	-2.0	-1.9	-1.5	-1.2	-1.0	-0.8	-1.6	-1.2	-1.6	-1.5	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.2	-1.5	-0.7	-1.0	-1.1	-0.3	-1.8	-0.9	-1.6	-1.5	-1.4	-1.6	-1.4
Supplements: Glucosamine	1.3	1.7	3.2	-1.6	-0.8	-1.2	-1.6	-0.5	-1.6	-0.5	-1.8	-1.0	-1.7	-1.5	-0.9
High blood pressure (mother)	1.3	1.8	3.8	-1.5	-1.4	-1.7	-0.1	-1.6	-1.9	-1.3	-0.9	-0.3	-0.7	-1.8	-1.2
Falls in the last year	1.3	1.7	5.5	-0.5	-1.8	-0.9	-2.3	-0.8	-1.0	0.1	-1.7	-0.3	-1.8	0.0	-1.7
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.7	-0.6	-1.6	-1.5	-1.3	-1.9	-0.9	-1.2	-1.6	-0.6	-1.4	-1.0	-0.9
Ever smoked	1.3	2.2	4.5	-0.9	-1.3	-1.3	-2.1	-1.8	-1.2	-1.1	-2.1	-1.0	-2.1	-0.5	-1.5
Depression (Nagel 2018)	1.2	1.8	4.4	-1.3	-1.2	-1.3	-1.3	-2.1	-1.8	-0.6	-1.0	-1.4	-1.1	-0.8	-1.4
Mean Putamen Volume	1.2	1.3	5.1	-0.0	1.0	-0.0	2.3	-0.9	-0.2	0.8	1.1	1.0	1.9	-0.1	1.6
Ulcerative Colitis	1.2	1.8	4.7	0.2	-1.9	-0.5	-2.2	0.5	0.8	-1.2	-1.5	0.0	-2.0	-0.6	-1.8
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.4	-0.6	-0.8	-0.9	-1.3	-0.5	-1.6	-2.1	-1.5	-0.9	-1.3	-1.0	-1.2
Forced vital capacity (FVC)	1.2	4.6	9.3	-3.0	-1.6	-1.9	-1.0	-1.4	-2.7	-2.0	-1.9	-3.0	-1.8	-2.3	-2.1
Illnesses of siblings	1.2	1.6	4.5	1.3	0.7	1.5	0.4	1.1	2.0	2.1	1.2	1.4	1.1	0.5	0.6
Depression (self-reported)	1.2	1.4	3.7	1.9	1.4	1.1	-1.1	0.3	0.3	1.8	-0.0	1.3	0.0	1.7	0.8
Breastfed as a baby	1.2	1.5	4.9	-0.6	1.4	0.6	1.5	0.8	-1.2	2.2	1.2	1.3	1.4	-0.1	1.1
Medication: Blood pressure	1.2	2.2	5.9	1.7	1.9	1.2	1.2	-0.2	0.4	1.6	1.1	2.4	1.6	0.8	1.9
Medication: Allopurinol	1.2	1.6	2.5	0.8	1.1	1.1	1.6	1.0	1.4	1.2	1.5	0.8	1.5	1.5	1.3
Commuting to job workplace: Public transport	1.2	1.4	2.8	1.2	1.7	1.2	0.5	1.2	1.2	1.4	1.0	0.7	1.1	1.0	1.5
Medication: Paracetamol	1.2	1.8	8.0	0.4	-0.7	-1.5	-1.0	-1.3	-1.9	-1.4	-0.9	-2.8	-0.7	-1.1	-0.4
Medication: Atorvastatin	1.2	1.5	6.4	2.5	1.9	0.8	1.0	0.4	0.5	0.7	0.8	1.0	1.2	0.0	1.5
Alzheimer’s Disease (in mother)	1.1	1.3	3.6	0.6	1.5	1.0	1.9	1.3	0.8	0.6	1.4	0.5	1.6	0.2	1.2
Crohns Disease (2017)	1.1	2.3	6.3	0.2	-0.3	-1.6	-2.1	-1.7	-1.5	-1.5	-2.5	-1.2	-2.0	-1.2	-0.4
Allergy or Eczema	1.1	2.9	5.2	-1.9	-2.2	-1.1	-1.9	-0.4	-1.8	-1.0	-1.9	-1.1	-1.9	-1.7	-2.3
Ever had hysterectomy (womb removed)	1.1	1.2	5.5	2.4	1.5	0.9	0.6	0.8	-0.0	0.3	0.6	1.3	0.7	1.0	1.3
Qualifications: College or University degree	1.1	3.6	8.6	-1.9	-1.8	-1.5	-2.9	-2.5	-0.6	0.4	-2.2	-1.0	-2.5	-0.9	-2.2
Family relationship satisfaction	1.1	1.3	5.3	0.7	0.4	0.6	0.1	0.7	1.5	2.1	0.5	2.3	0.4	1.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	3.6	0.9	-0.6	-1.4	-1.9	-0.3	-0.3	0.1	-1.6	-0.6	-1.6	-1.5	-0.6
Alcohol drinker status: Previous	1.1	1.3	2.9	-1.6	-1.1	-1.3	-0.0	-1.7	-1.1	-1.1	-0.4	-1.2	-0.5	-1.2	-1.3
Number of treatments/medications taken	1.0	1.9	4.5	-0.1	-0.4	-1.4	-1.6	-0.7	-2.0	-1.4	-2.1	-1.0	-1.7	-1.7	-0.6
Had menopause	1.0	1.3	2.6	-0.8	-0.9	-1.1	-0.9	-0.6	-1.6	-1.5	-0.9	-1.1	-1.2	-1.1	-1.3
Medication: Lansoprazole	1.0	1.2	3.7	-0.4	-1.0	-1.2	-0.7	-1.6	-1.9	-0.7	-0.7	-1.5	-0.4	-0.8	-0.7
Emphysema/chronic bronchitis	1.0	1.1	3.3	1.8	0.9	0.4	1.1	1.0	1.1	0.4	0.6	1.3	1.2	-0.0	1.5
Type 2 Diabetes (T2D) (2018)	0.9	1.7	6.4	-1.5	-1.2	-2.4	0.1	-0.7	-1.5	-0.4	-0.3	-1.0	-0.0	-2.5	-0.8
Relative age of first facial hair	0.9	1.8	5.7	-1.3	-1.9	-1.2	-0.8	-1.2	-0.3	-1.2	-0.7	-1.5	-1.0	-1.0	-2.4
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.2	-2.0	-2.0	-1.2	-1.3	-0.5	-1.1	-0.7	-1.5	-0.8	-1.4	-1.4	-1.9
Hair/balding pattern: Pattern 4	0.9	2.2	4.1	1.0	1.7	1.5	2.0	2.0	0.6	0.6	1.9	0.9	1.8	0.6	2.0
Suffer from ‘nerves’	0.9	1.5	6.2	-1.1	-0.1	-1.1	0.3	-1.6	-2.5	-1.2	-0.6	-1.9	-0.2	-1.0	-0.2
Had major operations	0.9	1.1	2.6	0.9	1.6	1.3	0.7	1.2	-0.5	0.7	0.3	1.1	0.6	1.0	1.6
Smoking status: Previous	0.9	1.3	2.3	-1.5	-1.3	-1.3	-0.7	-1.0	-1.5	-1.2	-1.1	-1.5	-0.9	-0.4	-0.9
Medication: Gliclazide	0.9	1.0	4.5	0.1	-0.1	-2.1	-0.2	-1.2	-0.4	-1.1	-0.9	-0.6	-0.5	-1.6	-0.0
Ulcerative Colitis (UC)	0.8	1.5	3.8	0.0	-1.7	-0.6	-2.0	0.1	0.0	-1.2	-1.4	-0.3	-1.9	-0.8	-1.8
Major Depression (MDD)	0.8	1.0	2.5	-0.9	-0.7	-1.1	-1.2	-0.9	-1.6	-0.3	-1.1	-1.3	-1.0	-0.5	-0.6
Body Mass Index (BMI) (2010)	0.8	1.1	2.2	0.5	1.4	0.8	1.5	1.1	-1.3	-0.5	1.2	-0.5	1.4	-0.2	1.3
Medication: Co-codamol	0.8	0.9	2.3	1.2	0.7	0.5	-1.5	-0.3	0.0	-1.2	-1.0	-0.5	-1.0	1.4	0.8
Hair/balding pattern: Pattern 3	0.8	1.1	2.9	-0.4	-1.1	-1.2	-1.7	-0.8	-0.7	-0.5	-1.7	-0.6	-1.4	-1.0	-0.6
Mouth/teeth dental problems: Dentures	0.8	1.3	2.8	1.7	1.2	0.8	1.1	0.7	1.6	-0.4	0.8	0.7	0.9	1.4	1.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.5	-0.4	-1.4	-1.1	-0.9	-1.9	-0.7	-1.2	-1.0	-0.3	-0.8	-0.2	-1.0
Pulse wave peak to peak time	0.8	1.0	2.3	1.0	1.4	0.8	1.4	-0.2	-0.2	-0.1	1.5	-0.0	1.5	0.6	1.0
Alcohol intake frequency.	0.8	1.9	5.7	-0.1	0.6	-2.1	1.0	-2.2	-1.9	-0.6	0.1	-1.4	0.5	-2.4	0.7
Friendships satisfaction	0.8	1.0	5.6	-1.5	-0.5	0.4	0.2	0.6	0.5	1.6	0.3	2.4	0.2	1.0	-0.1
Illnesses of father: High blood pressure	0.8	0.9	3.6	0.0	0.7	0.5	1.9	-0.2	0.5	0.4	1.4	0.2	1.7	0.2	1.3
Irritability	0.8	1.3	4.8	-2.0	-1.0	-0.9	0.1	-1.6	-2.2	-0.1	-0.4	-1.3	-0.2	-0.7	-0.8
Schizophrenia vs Biploar Disorder	0.7	0.9	2.6	0.5	0.2	1.0	1.3	0.4	0.9	0.3	1.6	0.3	1.1	1.3	1.0
Supplements: Zinc	0.7	0.8	2.2	-0.4	-0.4	0.4	-1.3	1.5	-0.5	-0.5	-1.0	0.5	-1.4	0.7	-0.8
Fed-up feelings	0.7	1.2	2.6	-0.3	-1.4	-0.0	-1.6	-1.0	-1.4	-1.5	-1.0	-0.5	-1.3	0.9	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.4	-1.3	-1.3	-1.0	-0.7	-1.6	-0.8	0.0	-0.8	-0.8	-0.7	-0.7	-1.4
Neuroticism score	0.7	1.4	6.4	-1.0	-0.6	-0.5	-0.6	-2.2	-2.5	-1.0	-0.7	-1.3	-0.6	0.1	-0.6
Noisy workplace	0.7	0.8	3.1	-0.1	0.1	-0.8	1.4	-1.8	-0.2	-0.7	0.8	-1.1	1.0	-0.6	0.8
Medication: Cholesterol lowering	0.7	1.0	4.0	1.4	1.2	1.0	0.6	-0.0	0.9	0.9	0.6	2.0	0.7	-0.1	1.1
Mineral and other dietary supplements	0.7	1.0	2.4	1.1	0.6	1.0	1.3	0.5	1.2	0.5	1.6	0.5	1.4	0.9	0.7
Smoking status: Current	0.7	1.1	6.6	2.6	1.0	0.7	0.0	0.8	0.9	-0.0	0.0	0.8	0.4	0.8	1.3
Myopia	0.7	1.0	4.1	1.4	0.5	0.7	-0.5	0.4	1.5	1.5	-0.5	2.0	-0.1	0.6	0.3
Worry (Nagel 2018)	0.6	1.3	7.4	-1.9	-0.3	-0.6	0.3	-2.7	-1.5	-0.6	-0.1	-1.0	-0.0	0.4	-0.6
Crohns Disease (2012)	0.6	0.9	2.4	-0.0	0.0	-1.1	-1.4	-1.5	-0.3	-0.5	-1.4	-0.2	-1.5	-1.2	-0.2
HDL Cholesterol	0.6	1.0	1.9	1.1	1.0	1.1	0.8	0.6	0.3	1.4	1.0	1.4	1.0	0.1	1.3
Lupus	0.6	0.9	2.4	0.9	1.6	1.3	-0.0	1.1	0.6	1.0	0.1	1.0	0.4	0.8	1.1
Neuroticism	0.6	1.4	6.3	-1.1	-0.3	-0.4	-0.3	-2.5	-2.1	-1.0	-0.5	-1.6	-0.4	0.5	-0.5
Diabetes (father)	0.6	0.7	2.4	0.5	0.4	0.2	1.5	0.2	-0.8	-0.5	1.0	1.0	1.3	-0.1	1.2
Past tobacco smoking	0.6	1.2	1.9	0.7	1.1	1.1	1.1	1.3	1.2	1.4	1.2	1.2	1.1	0.3	0.8
Asthma	0.6	1.1	3.0	0.1	0.3	0.3	1.7	0.2	1.1	1.5	1.6	1.1	1.7	0.1	0.5
Pulse wave Arterial Stiffness index	0.6	0.7	1.8	-1.0	-1.2	-0.7	-1.2	0.4	0.2	0.1	-1.3	0.2	-1.4	-0.5	-0.8
Exposure to tobacco smoke outside home	0.6	0.8	1.9	1.2	0.7	0.2	1.4	0.4	-0.2	-1.3	0.6	-0.8	1.2	0.1	1.3
Comparative body size at age 10	0.6	1.8	5.1	2.3	0.6	1.3	0.3	1.7	2.0	0.4	0.5	1.6	0.5	1.3	1.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	-0.6	-0.9	-0.0	-1.2	0.8	-1.2	-0.7	-1.2	-0.6	-1.0	-0.2	-0.9
Heart disease (mother)	0.6	0.7	3.6	0.4	-0.0	0.7	1.0	0.3	1.9	0.3	0.9	0.7	0.6	1.2	0.4
Chest pain or discomfort	0.6	0.9	3.2	-0.3	1.0	0.4	1.8	0.5	-0.8	0.8	0.7	0.6	1.4	-0.3	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.6	-1.2	0.2	-0.7	0.4	-0.8	-1.4	-0.7	-0.2	-1.6	0.1	-0.4	-0.2
Illnesses of siblings: Diabetes	0.6	0.7	5.1	0.4	0.4	-0.2	0.6	-0.7	-0.7	-2.3	-0.3	-0.9	-0.0	0.5	0.6
Medication for cholesterol	0.6	0.9	4.1	-0.2	-0.0	0.4	0.9	0.2	0.6	2.0	1.4	0.6	1.5	-0.4	0.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	0.9	0.1	-0.8	-1.2	-0.8	-0.6	1.1	-0.9	1.2	-0.9	-0.9	-0.3
Fractured/broken bones in last 5 years	0.6	0.8	1.6	0.4	0.5	1.2	1.1	0.8	1.2	0.2	1.2	0.7	0.9	0.9	0.7
Commuting to job workplace: Cycle	0.6	0.8	2.1	0.1	-0.4	-0.8	-1.5	-1.2	0.3	-1.0	-0.9	-0.2	-1.1	-0.6	-1.1
Supplements: Calcium	0.6	0.6	1.6	-1.0	-0.5	-0.4	-1.3	-0.1	-0.7	0.5	-0.8	-0.6	-0.9	-0.8	-1.1
Basal cell carcinoma (self-reported)	0.6	0.7	3.1	-0.8	-0.5	-0.2	-0.8	0.5	-1.8	-0.2	-0.7	0.3	-0.9	-1.4	-0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.2	1.8	-1.1	-1.0	-1.3	-1.1	-1.2	-1.0	-0.3	-1.3	-0.3	-1.2	-1.3	-1.2
Primary Biliary Cirrhosis	0.5	0.7	3.9	2.0	1.3	0.9	-0.0	0.1	0.3	0.5	0.7	0.5	0.6	0.4	0.9
BMI	0.5	3.1	8.2	2.7	2.5	0.6	2.3	1.5	-0.5	-0.4	1.5	0.7	2.1	-0.5	2.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.4	-0.8	-0.4	-0.7	-0.6	-1.1	-1.2	0.6	-0.5	-0.7	-0.6	-1.0	-0.8
Medication for hormone replacement therapy	0.5	0.6	1.9	0.3	0.4	0.0	-1.4	-0.1	-0.0	-0.9	-1.0	-0.0	-1.3	0.2	-1.0
Hand grip strength (right)	0.5	1.3	3.1	-1.0	-1.1	-1.2	0.0	-0.9	-1.7	-1.3	-0.3	-1.8	-0.1	-1.6	-1.0
Multivitamins +/- minerals	0.5	0.6	2.3	0.4	0.6	1.0	0.5	1.5	0.4	1.2	0.7	0.7	0.7	0.3	0.5
Stomach or abdominal pain in last month	0.5	0.6	2.4	-0.8	-0.7	-0.9	-0.3	-1.2	-0.6	0.1	-0.4	-0.2	-0.2	-1.6	-1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.1	-1.4	-0.4	-0.1	-0.6	-1.0	-0.5	-0.6	-0.6	-0.1	-0.8	0.9	-0.8
Trunk fat mass	0.5	2.0	4.8	2.2	1.9	1.3	1.6	1.8	-0.4	-0.6	1.0	1.4	1.5	0.3	1.8
Alcohol usually taken with meals	0.5	0.8	1.9	-0.9	0.2	-0.6	-1.4	-0.9	-0.9	0.7	-1.4	-0.8	-1.2	-0.8	-0.5
Hair/balding pattern: Pattern 2	0.5	0.6	2.1	0.7	0.4	-0.7	-0.1	-1.1	-1.0	-1.5	-0.7	-1.0	-0.4	-0.4	-0.4
Financial difficulties in last 2 years	0.5	0.7	2.6	0.0	-0.4	-0.0	-1.6	-0.1	-0.9	-1.1	-0.7	-1.2	-1.2	-0.2	-0.4
Alcohol intake versus 10 years previously	0.5	0.7	2.2	-0.0	-0.6	-0.6	-0.6	-1.2	-0.9	-1.5	-1.0	-1.2	-0.8	-0.0	-0.2
Happiness	0.5	0.7	3.6	0.6	0.5	0.7	-0.4	0.4	1.0	0.5	-0.1	1.9	-0.3	1.3	0.1
Illnesses of mother	0.5	0.6	1.7	0.8	0.9	1.3	-0.4	1.3	0.9	0.6	0.2	0.6	-0.0	0.7	0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	4.3	-1.2	-1.0	-0.7	-0.2	0.8	-0.2	-0.8	-0.2	-2.1	-0.5	-0.2	-0.7
High blood pressure (siblings)	0.5	0.7	2.4	-1.0	0.1	-0.9	-0.3	-1.1	-1.5	-1.1	-0.9	-0.7	-0.8	0.1	-0.1
Forced vital capacity (FVC), Best measure	0.5	1.9	5.3	-2.3	-1.1	-1.2	-0.5	-0.7	-1.4	-1.2	-1.3	-1.9	-1.3	-1.4	-1.4
Arm fat-free mass (right)	0.5	2.4	5.0	1.9	2.1	0.9	2.0	1.9	-0.2	-0.2	1.5	-0.1	1.9	-0.7	2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.4	0.1	-0.2	1.4	0.0	0.4	0.6	0.1	0.9	0.3	0.4	1.9	-0.1
Shortness of breath walking on level ground	0.5	0.6	1.3	0.4	0.2	1.1	0.8	1.1	1.0	0.1	0.6	0.4	0.7	0.9	0.7
Eye problems/disorders: None of the above	0.5	0.6	2.3	-0.4	-1.3	-0.7	-0.3	-1.5	-0.0	0.2	-0.6	0.6	-0.4	0.1	-1.3
Whole body fat mass	0.5	2.1	5.7	2.4	1.8	1.3	1.6	1.7	-0.4	-0.5	0.9	1.5	1.5	0.2	2.0
Leg fat mass (right)	0.5	1.8	5.0	2.2	1.4	0.7	1.6	1.4	-0.5	-0.5	0.9	1.4	1.5	-0.2	1.9
Leg pain on walking	0.5	0.7	1.7	1.2	0.7	-0.2	1.0	0.7	-0.0	-1.3	0.7	-1.0	0.7	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.4	0.6	1.3	1.0	1.5	1.5	0.2	0.1	1.4	-0.3	1.3	0.2	1.0
Long-standing illness, disability or infirmity	0.5	0.8	3.0	-0.5	-0.5	-0.8	-1.2	-0.1	-0.9	-0.7	-1.7	0.1	-1.4	-0.5	-0.9
Eye problems/disorders: Cataract	0.5	0.6	1.6	0.4	0.9	0.2	0.9	1.3	0.8	-0.1	1.0	-0.6	0.8	-0.4	1.1
Asthma (self-reported)	0.5	0.9	2.7	0.0	0.4	0.1	1.6	0.0	0.8	1.4	1.4	0.7	1.6	-0.1	0.6
Hearing aid user	0.5	0.6	4.8	-0.0	0.1	-0.6	-0.7	-2.2	-0.3	0.4	-0.4	0.3	-0.4	0.0	-0.8
High cholesterol (Self-reported)	0.5	1.0	2.6	0.5	-0.5	-0.6	-1.1	-0.9	-0.6	-1.3	-1.6	1.4	-1.3	-0.8	-0.4
Medication: Lisinopril	0.5	0.6	2.8	0.5	0.3	0.8	0.2	-0.4	0.7	0.8	0.6	1.7	0.5	0.9	0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.6	-0.6	-1.4	-0.4	0.0	-0.8	-0.4	-1.6	-0.2	-0.3	-0.2	0.3	-1.0
Alzheimer’s Disease (in father)	0.4	0.5	1.8	0.4	-0.2	-0.1	-0.1	1.0	-1.1	-1.3	-0.6	-0.9	-0.5	-0.2	-0.1
Prostate Cancer	0.4	0.6	2.2	-1.5	-0.9	-0.8	-0.0	-0.5	-0.8	-0.1	-0.3	-0.6	-0.0	-0.8	-1.0
Bipolar Disorder (2011)	0.4	0.4	1.2	0.6	0.8	-0.2	1.1	0.1	0.5	0.3	0.8	-0.0	0.9	-0.3	0.8
Coronary Artery Disease (CAD)	0.4	0.4	2.5	-0.2	-0.6	-0.1	-0.6	0.3	-0.5	-1.6	-0.8	-0.2	-0.6	-0.2	-0.6
HbA1C	0.4	0.5	1.9	-0.3	0.3	-0.2	-1.4	-0.4	-0.8	0.6	-1.0	-0.1	-1.0	-0.8	-0.1
Neuroticism (2016)	0.4	0.5	2.6	0.1	-0.4	-0.1	0.7	-0.2	-1.1	-1.6	0.5	-1.0	0.6	0.3	0.0
Heel T-Score	0.4	3.4	9.5	0.1	-1.4	-2.2	-3.1	-1.4	-1.0	-0.9	-2.6	-1.5	-2.6	-1.8	-1.2
Medication: Metformin	0.4	0.5	2.3	0.6	0.3	-1.4	0.6	0.0	0.6	0.1	-0.0	0.4	0.4	-1.5	0.5
Diabetes (mother)	0.4	0.6	2.7	-0.8	-0.2	-0.7	-0.3	-1.6	-1.3	-0.4	-0.4	-0.1	-0.2	-0.7	-0.3
Leg fat-free mass (left)	0.4	2.1	3.9	1.8	1.9	1.1	1.9	2.0	0.0	0.3	1.5	0.5	1.8	-0.5	1.8
Trunk fat percentage	0.4	1.7	4.7	2.2	1.6	1.2	1.3	1.4	-0.4	-0.7	0.7	1.5	1.2	0.4	1.6
Current tobacco smoking	0.4	0.6	4.4	2.1	0.5	0.4	-0.2	0.9	0.7	-0.0	-0.3	0.4	0.0	0.4	0.8
Maternal smoking around birth	0.4	0.6	3.4	0.1	0.3	-0.1	1.1	0.5	-1.9	-0.4	0.2	-0.3	1.0	-0.7	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.7	-0.4	-1.2	-0.9	-1.2	-0.4	-0.7	-1.1	-1.2	-0.6	-1.3	-0.5	-0.7
Leg predicted mass (left)	0.4	2.1	4.0	1.9	1.9	1.1	1.9	2.0	0.1	0.3	1.5	0.5	1.8	-0.5	1.9
Mouth/teeth dental problems	0.4	0.6	2.0	0.7	0.7	1.2	0.7	1.0	0.1	0.5	0.9	1.4	0.8	0.1	0.3
Prospective memory result	0.4	0.5	1.5	0.1	0.5	0.1	1.2	0.2	0.9	0.8	0.5	0.8	1.1	-0.2	0.6
Exposure to tobacco smoke at home	0.4	0.4	1.1	1.1	0.6	0.3	0.3	-0.4	0.8	0.7	0.5	0.6	0.7	0.6	0.9
Body fat percentage	0.4	1.6	5.4	2.3	1.4	1.1	1.1	1.3	-0.5	-0.6	0.6	1.6	1.2	0.3	1.6
Leg fat percentage (right)	0.4	1.3	4.5	2.1	1.0	0.7	1.2	1.0	-0.4	-0.4	0.8	1.6	1.2	0.1	1.6
Mean time to correctly identify matches	0.4	0.8	3.7	0.5	-0.0	-0.2	-1.9	0.5	-0.4	0.2	-1.2	0.0	-1.6	-0.1	-0.8
Arm predicted mass (right)	0.4	2.0	4.1	1.7	2.0	0.6	1.9	1.5	-0.5	-0.4	1.3	-0.4	1.7	-0.9	2.0
Pulse rate, automated reading	0.4	1.2	3.6	1.2	1.1	1.0	1.3	0.4	0.9	0.6	1.0	1.9	1.4	1.0	0.8
Number of full sisters	0.4	0.5	2.2	0.8	-0.6	-0.4	-0.5	0.8	-0.8	-0.5	0.1	-1.5	0.1	-0.9	-0.3
Knee pain experienced in last month	0.4	0.6	2.0	-0.1	0.1	-0.3	-0.9	-1.0	-1.4	-0.2	-1.2	0.2	-0.7	-1.0	-0.4
Ever had bowel cancer screening	0.4	0.5	1.9	0.1	0.4	-0.5	-0.8	-1.4	-0.6	0.0	-0.8	0.4	-0.8	-0.5	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.7	0.6	0.7	-0.4	1.3	0.4	0.5	0.8	0.4	-0.4	0.9	-0.3	0.6
Qualifications: nursing, teaching	0.4	0.6	1.9	0.7	-0.7	-0.2	-1.4	-0.2	1.3	-0.3	-0.6	0.2	-1.0	0.3	-1.1
Number of self-reported non-cancer illnesses	0.4	0.7	1.9	-0.1	-0.5	-1.0	-1.0	-1.0	-1.2	-0.2	-1.4	0.6	-0.9	-0.9	-0.6
Average weekly champagne plus white wine intake	0.4	0.5	2.9	0.9	0.6	0.5	-0.2	0.9	1.1	0.1	-0.0	1.7	-0.1	0.1	0.2
Guilty feelings	0.4	0.7	3.3	-0.5	-0.9	-0.3	0.0	-0.6	-1.8	-0.2	0.2	-1.6	0.3	-0.2	-0.5
Tinnitus: Yes, now most or all of the time	0.4	0.4	2.0	1.4	-0.1	-0.1	-0.2	0.9	-1.1	-0.6	-0.3	0.4	0.0	-0.2	0.7
Medication: Bendroflumethiazide	0.4	0.7	1.8	0.6	1.3	0.7	1.1	0.4	0.0	0.5	0.7	0.5	0.9	1.2	0.8
Leg fat percentage (left)	0.4	1.4	4.8	2.2	1.3	0.7	1.2	1.0	-0.6	-0.6	0.7	1.3	1.2	0.3	1.7
Arm fat-free mass (left)	0.4	2.0	4.3	2.0	1.9	1.0	1.7	1.8	-0.1	-0.1	1.4	0.2	1.6	-0.6	2.1
Number of operations (self-reported)	0.4	0.6	2.4	-1.4	-0.4	-0.6	-0.2	-0.9	-1.5	-0.3	-0.9	-0.3	-0.3	0.0	-0.5
Cholesterol lowering medication	0.4	0.6	2.0	0.2	-0.6	-0.4	-0.6	-0.3	0.1	-1.3	-1.4	-0.1	-1.2	0.3	-0.6
Leg fat mass (left)	0.4	1.7	5.1	2.3	1.5	0.7	1.6	1.3	-0.7	-0.6	0.8	1.2	1.4	-0.2	2.0
Arm predicted mass (left)	0.4	2.3	4.7	2.0	2.1	1.0	2.0	1.7	-0.0	0.2	1.6	0.3	1.9	-0.6	2.2
Bipolar Disorder (2018)	0.3	0.5	1.2	-0.8	-1.1	-1.0	-0.3	-0.9	-0.7	-0.7	-0.2	-0.1	-0.4	-0.7	-0.8
Neuroticism (Nagel 2018)	0.3	0.7	2.4	-1.2	-0.1	0.4	0.1	-1.5	-1.5	-0.6	0.3	-0.9	0.1	1.1	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	0.9	0.4	0.8	-0.3	0.9	0.4	0.0	-0.6	0.1	-0.3	0.6	-0.5
Waist Hip Ratio (WHR)	0.3	1.4	3.2	-1.5	-1.8	-1.1	-1.4	-1.0	-0.4	0.4	-1.4	-0.2	-1.3	-0.7	-1.6
Angina	0.3	0.4	2.3	-0.1	0.4	-0.4	0.9	-1.5	0.0	0.4	0.6	0.1	0.6	-0.7	0.2
Vitamin and mineral supplements	0.3	0.4	2.0	-0.3	-0.5	-1.0	-0.1	-1.4	-0.1	-1.2	-0.2	-0.4	-0.1	-0.6	-0.2
Average weekly fortified wine intake	0.3	0.4	1.4	0.4	-0.1	0.3	-1.2	-0.1	-0.3	-0.9	-0.8	0.0	-0.9	0.7	-0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.7	1.0	1.3	0.9	-0.0	0.5	-0.1	-0.3	0.1	-0.0	0.2	0.5	0.4
Chronic bronchitis/emphysema (father)	0.3	0.3	1.6	0.2	0.5	0.4	-0.1	0.9	0.6	1.3	0.2	0.4	0.1	-0.1	0.2
Pain all over the body in last month	0.3	0.3	1.2	0.2	-0.3	-0.6	-0.6	-1.1	-0.6	0.1	-0.8	0.4	-0.7	-0.4	0.1
Fluid intelligence score	0.3	0.7	1.9	-1.4	-0.4	-0.7	-0.5	-1.1	-1.3	-0.6	-0.6	-0.2	-0.8	-0.7	-0.8
Arm fat percentage (right)	0.3	1.1	4.6	2.1	0.9	1.0	0.8	1.1	-0.1	-0.6	0.5	1.5	0.9	0.4	1.2
Number of live births	0.3	0.5	1.4	-0.5	-0.9	-1.2	0.5	-0.5	-0.2	-1.1	-0.2	-0.9	-0.0	-0.7	-0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.0	-0.7	-0.2	-0.6	-1.4	-1.0	-0.4	0.2	-0.8	-1.0	-1.3	-0.2	-1.3
Arm fat mass (right)	0.3	1.4	4.5	2.1	1.2	0.8	1.4	1.3	-0.3	-0.9	0.7	1.2	1.2	-0.0	1.5
Tense / ‘highly strung’	0.3	0.4	2.1	-1.0	0.1	0.2	-0.2	-1.4	-0.1	0.2	-0.3	0.4	-0.2	1.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	4.3	-0.6	-0.1	-0.4	-0.0	-2.1	-0.8	0.6	-0.4	0.2	-0.1	0.1	-0.2
Birth weight of first child	0.3	0.5	1.2	0.3	0.9	0.4	0.8	1.0	-0.1	1.0	0.5	0.3	0.7	-0.3	1.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.7	-0.9	0.7	0.2	0.4	0.1	0.5	0.8	0.2	-1.3	0.3	0.5	0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	2.8	-1.2	-0.3	-0.6	0.4	0.5	-1.0	1.1	0.2	-0.6	0.1	-1.7	0.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	-0.4	-0.6	-0.7	-0.2	-0.5	-0.9	-0.5	-0.5	-0.8	-0.3	0.4	-0.5
Wheeze or whistling in the chest in last year	0.3	0.5	1.5	-1.2	-1.2	-0.4	0.3	0.5	0.0	0.3	0.2	0.9	0.2	-0.8	-0.9
Number of children fathered	0.3	0.4	0.7	0.6	0.6	0.9	0.5	-0.2	-0.7	-0.0	0.7	0.4	0.7	0.7	0.8
Age at first live birth	0.3	0.5	1.9	-0.2	0.4	0.3	1.3	0.1	0.1	0.8	1.3	-0.2	1.4	-0.2	0.6
Angina (self-reported)	0.3	0.4	1.9	-0.2	0.3	-0.5	0.8	-1.4	0.0	0.5	0.6	0.2	0.6	-0.9	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.6	1.3	0.2	0.5	-0.3	0.8	0.2	-0.6	0.1	-0.1	-0.1	0.8	0.2
Age at last live birth	0.3	0.5	1.8	0.5	0.4	0.4	0.7	0.7	0.4	1.4	0.9	0.1	0.9	0.6	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.4	-0.4	-0.2	-0.6	0.1	-0.7	0.1	1.2	0.4	0.5	0.5	-0.8	0.1
Supplements: Vitamin C	0.3	0.3	2.7	-0.2	0.1	0.6	-0.0	1.6	-0.4	0.6	0.1	-0.1	-0.2	0.0	0.2
Whole body fat-free mass	0.3	1.6	3.2	1.5	1.8	0.9	1.6	1.8	0.0	0.3	1.4	0.1	1.5	-0.7	1.7
Leg fat-free mass (right)	0.3	1.7	3.5	1.5	1.9	1.0	1.8	1.8	-0.2	0.2	1.3	0.2	1.6	-0.6	1.6
Commuting to job workplace: Walk	0.3	0.3	0.9	-0.6	-0.4	-0.2	-0.6	-0.3	-0.5	0.5	-0.9	-0.1	-0.9	-0.4	-0.9
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	-0.1	-0.8	-0.4	-0.9	-0.2	0.0	-1.0	-0.3	-0.8	-0.6	0.0	-1.0
Whole body water mass	0.3	1.8	3.4	1.6	1.8	1.0	1.6	1.8	0.1	0.4	1.4	0.2	1.6	-0.6	1.8
Leg predicted mass (right)	0.3	1.6	3.3	1.4	1.8	0.9	1.8	1.8	-0.2	0.1	1.3	0.2	1.6	-0.6	1.6
Arm fat mass (left)	0.3	1.3	3.8	2.0	1.0	0.7	1.2	1.6	-0.5	-1.0	0.5	1.1	1.1	-0.2	1.4
Miserableness	0.3	0.5	2.0	-0.3	-0.9	0.5	-1.3	0.3	-0.6	-0.3	-0.3	-0.0	-0.8	1.4	-0.2
Wears glasses or contact lenses	0.3	0.4	0.8	0.9	0.5	-0.4	0.8	-0.6	-0.4	0.5	0.5	-0.7	0.8	-0.4	0.7
Ever taken oral contraceptive pill	0.3	0.3	1.3	1.0	-0.1	0.2	-0.8	1.2	-0.2	0.1	-0.4	-0.3	-0.3	-0.6	-0.0
Eye problems/disorders: Glaucoma	0.3	0.4	1.3	-0.2	0.3	0.0	-0.8	1.1	-1.1	0.1	-0.8	-0.1	-0.8	-0.3	0.2
Basal metabolic rate	0.3	1.8	3.4	1.7	1.8	0.9	1.7	1.9	-0.0	0.1	1.4	0.3	1.6	-0.6	1.8
Depressed Affect (Nagel 2018)	0.2	0.5	1.7	-0.2	-0.3	0.7	-1.1	-0.5	-1.2	-0.3	-0.1	-0.1	-0.5	1.3	-0.3
Reaction Time	0.2	0.3	1.5	0.5	0.2	0.3	-0.7	1.2	-0.0	0.7	-0.4	-0.2	-0.6	0.4	-0.4
Breast Cancer	0.2	0.5	1.6	-0.6	-0.5	-0.4	-0.8	0.3	-0.4	-0.0	-0.5	-0.9	-0.7	-1.3	-0.9
Rheumatoid Arthritis	0.2	0.3	0.8	-0.7	0.2	0.7	0.8	-0.5	0.1	0.3	0.3	0.5	0.7	0.9	0.4
Triglycerides	0.2	0.3	0.8	-0.2	-0.1	0.1	0.7	0.8	-0.2	0.2	0.9	-0.4	0.8	-0.5	0.5
Blood White Count	0.2	1.4	3.6	0.9	0.6	1.1	1.0	0.8	1.7	1.4	1.0	1.9	1.0	1.2	1.0
Smoking Status	0.2	0.5	1.3	0.8	-0.9	-0.4	-1.2	0.3	-0.2	-0.5	-1.1	-0.4	-0.8	0.5	-0.4
Cardiovascular Disease	0.2	0.6	1.5	0.5	1.0	0.6	0.7	0.0	-0.4	-1.1	-0.0	1.1	0.5	0.5	1.2
Hypothyroidism (self reported)	0.2	0.6	1.9	-1.4	-0.2	-0.5	0.5	0.2	-0.6	0.9	0.5	-0.9	0.3	-1.3	0.2
Chronotype (morning person)	0.2	0.4	1.8	0.5	0.5	0.3	0.5	-0.3	-0.6	-1.3	-0.1	0.5	-0.0	0.8	0.8
Average weekly spirits intake	0.2	0.3	1.0	0.1	0.2	0.7	-0.3	1.0	0.4	0.6	0.1	0.5	-0.1	0.7	0.3
Sensitivity / hurt feelings	0.2	0.4	2.2	0.0	0.8	0.2	0.6	-1.5	-0.6	-0.6	0.1	-0.4	0.4	0.4	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	0.3	0.1	0.3	-0.6	-0.9	-0.8	0.1	-0.0	-0.5	-0.1	1.0	-0.1
Townsend deprivation index at recruitment	0.2	0.3	1.1	0.4	-0.7	-0.6	-1.1	0.2	0.0	0.6	-0.7	-0.1	-0.6	-0.5	-0.3
Taking other prescription medications	0.2	0.4	1.6	-0.4	0.1	-0.2	-0.5	-0.2	-1.3	0.5	-0.7	-0.3	-0.5	-1.1	-0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.7	-0.8	-0.2	0.3	-0.4	0.5	0.3	0.2	-0.1	-0.3	-0.6	0.2	-0.9
High blood pressure	0.2	0.6	2.6	0.8	1.0	0.4	0.4	-0.5	0.3	-0.2	-0.0	1.6	0.2	0.7	1.3
Medication: Atenolol	0.2	0.3	1.3	0.7	-0.2	0.0	-0.2	-0.6	0.3	-0.5	-0.5	0.5	-0.3	1.1	0.5
Medication: Levothyroxine sodium	0.2	0.4	2.3	-0.4	-0.1	-0.5	0.1	0.5	-1.1	0.4	-0.1	-0.2	-0.0	-1.5	0.3
Body mass index (BMI)	0.2	0.8	2.6	1.6	0.8	0.2	0.9	0.9	-0.9	-1.1	0.2	0.5	0.7	-0.7	1.2
Waist circumference	0.2	0.6	1.6	1.2	0.4	-0.3	0.3	0.9	-1.3	-0.8	-0.4	0.0	0.1	-1.1	0.7
Nervous feelings	0.2	0.3	1.6	-1.3	0.0	-0.0	0.6	-0.9	-1.0	0.0	0.4	-0.2	0.3	-0.1	-0.4
Had other major operations	0.2	0.3	0.9	-0.7	0.3	-0.4	0.8	-0.4	-0.2	-0.7	0.3	-1.0	0.5	0.1	0.4
Qualifications: None of the above	0.2	0.5	2.1	-0.2	0.4	0.2	1.4	0.4	-0.4	-1.3	0.4	-0.3	0.6	0.3	0.6
Heart attack	0.2	0.2	0.7	-0.4	-0.3	0.1	0.5	-0.1	0.8	0.6	0.3	0.9	0.3	0.1	0.2
Allergy	0.2	0.4	2.0	0.9	1.4	0.7	-0.2	-0.1	-0.2	-0.3	0.1	-0.3	-0.1	0.8	0.9
Diabetes (self-reported)	0.2	0.3	0.6	0.7	0.4	-0.6	0.8	0.7	0.4	-0.2	0.4	-0.1	0.6	-0.4	0.4
Medication: Simvastatin	0.2	0.3	2.0	0.4	0.1	-0.2	-0.1	-0.7	0.2	-0.4	-0.7	1.4	-0.4	-0.0	0.4
Weight	0.2	1.0	2.7	1.6	1.2	0.4	1.2	1.4	-0.8	-0.7	0.5	0.4	0.9	-0.8	1.3
Trunk fat-free mass	0.2	1.2	2.5	1.2	1.5	0.9	1.3	1.6	0.2	0.5	1.3	0.0	1.3	-0.5	1.4
Hip circumference	0.2	0.8	1.8	1.4	0.6	-0.3	0.4	1.3	-1.3	-0.9	-0.3	-0.2	0.3	-1.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.0	-0.5	-0.1	0.5	-0.4	0.3	0.6	0.8	0.1	0.4	-0.1	0.3	-1.0
Lung cancer (father)	0.2	0.3	1.3	0.3	-0.1	0.6	-0.6	0.0	1.1	-0.5	0.1	0.3	-0.1	1.0	0.1
Trunk predicted mass	0.2	1.2	2.6	1.3	1.5	0.9	1.3	1.6	0.2	0.5	1.3	0.0	1.3	-0.5	1.5
Loud music exposure frequency	0.2	0.2	1.7	0.1	-0.0	0.2	0.3	0.1	-0.4	-1.3	0.0	-0.5	0.1	0.6	0.1
Blood clot in the leg (DVT)	0.2	0.3	1.2	-0.4	-1.1	-0.1	0.3	-0.4	-0.2	-1.0	0.1	0.3	0.1	0.6	-0.7
Glaucoma (self-reported)	0.2	0.3	0.6	-0.3	0.6	0.4	-0.8	0.7	-0.5	0.7	-0.5	0.5	-0.5	0.4	0.3
Medication: Amlodipine	0.2	0.3	0.8	-0.9	-0.6	-0.1	-0.8	0.3	-0.6	0.2	-0.7	0.1	-0.7	0.2	-0.6
Number of full brothers	0.2	0.3	1.0	-0.6	-0.3	-0.9	0.3	-0.4	-0.8	0.2	-0.2	-0.6	0.1	-1.0	-0.1
Health satisfaction	0.2	0.3	1.2	-0.8	-0.6	-0.1	-0.4	0.0	-0.6	-0.0	-0.6	-0.1	-0.6	-0.2	-1.1
Medication: Seretide 50 evohaler	0.2	0.3	0.8	0.1	-0.4	-0.6	-0.6	-0.2	0.0	-0.8	-0.9	0.1	-0.8	-0.3	-0.1
Comparative height size at age 10	0.2	1.0	2.2	1.2	1.0	1.5	0.2	1.2	1.3	-0.2	0.4	0.8	0.1	1.3	1.0
Overall health rating	0.2	0.4	1.7	0.6	0.4	-0.8	0.1	-0.7	-0.8	0.4	-0.4	0.7	0.1	-1.3	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.0	0.0	0.1	-0.5	0.2	-0.4	-1.0	-0.0	0.1	0.4	0.2	-0.5	0.5
Hypertension (Self-reported)	0.2	0.6	2.7	0.6	1.0	0.5	0.4	-0.6	0.1	-0.0	-0.1	1.6	0.3	0.7	1.4
Illnesses of father: Heart disease	0.2	0.3	1.5	-0.5	0.1	0.3	0.1	0.4	0.4	1.2	0.1	1.1	0.0	-0.1	0.0
Arm fat percentage (left)	0.2	0.9	3.5	1.9	0.6	0.7	0.9	1.3	-0.4	-1.0	0.3	1.2	0.9	0.0	1.0
Mood swings	0.2	0.3	2.5	-0.5	-0.2	0.3	-0.6	-0.1	-1.6	-0.2	-0.3	-0.5	-0.3	0.3	0.2
Diabetes diagnosed by doctor	0.2	0.4	1.7	0.3	-0.5	-1.3	0.6	0.6	0.4	-0.6	0.1	0.0	0.4	-1.1	-0.1
Medication: Aspirin	0.2	0.2	0.6	0.8	0.6	0.6	0.5	0.4	0.5	-0.2	-0.0	0.2	0.2	0.6	0.7
Mother’s age at death	0.2	0.2	0.7	0.9	0.7	-0.2	-0.0	0.6	-0.2	0.1	-0.5	-0.2	-0.3	0.0	0.3
Medication: Blood pressure	0.2	0.4	0.9	-0.1	0.9	0.6	0.9	-0.1	-0.1	-0.1	0.2	0.8	0.4	0.9	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	-0.0	0.8	0.5	0.6	-0.8	-0.6	0.6	0.5	0.3	0.6	0.2	0.5
Risk taking	0.2	0.2	0.9	0.5	-0.7	-1.0	-0.1	0.3	0.6	-0.1	-0.7	0.2	-0.0	-0.4	-0.0
Diastolic blood pressure, automated reading	0.2	0.5	2.3	-0.4	-1.0	-0.5	-0.1	-0.6	-0.9	-1.5	-0.5	0.7	-0.4	0.1	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.8	-0.9	-0.8	-0.3	-0.4	0.9	-0.3	0.2	0.0	-1.7	-0.3	-0.6	-1.3
Bipolar Disorder or Schizophrenia	0.1	0.2	1.1	-1.1	-0.6	0.0	-0.0	-0.4	-0.8	0.0	0.2	-0.1	-0.1	0.3	-0.4
Schizophrenia (2018)	0.1	0.2	1.0	-0.7	0.1	0.8	0.2	0.3	-0.3	0.6	0.4	0.1	0.2	1.0	0.1
Schizophrenia (2014)	0.1	0.3	1.1	-0.9	-0.6	0.2	-0.3	-0.2	-0.7	-0.2	-0.2	-0.4	-0.5	1.0	-0.5
Blood Eosinophil Count	0.1	0.6	2.7	0.4	0.4	-0.5	1.2	-0.7	0.2	-0.5	0.6	-1.6	0.7	-0.2	0.6
Blood Platelet Count	0.1	1.2	2.5	1.3	1.2	1.0	0.6	1.1	1.2	1.6	0.7	1.2	0.8	1.4	0.6
Blood Red Count	0.1	0.6	2.2	0.8	0.4	0.1	1.5	0.0	-0.1	-0.8	1.1	-0.5	1.1	0.2	0.6
Height	0.1	1.5	3.0	-1.7	-1.7	-1.5	-1.2	-0.7	-0.7	-0.2	-0.9	-0.5	-1.3	-1.5	-1.7
Systolic Blood Pressure	0.1	0.5	2.0	-0.6	0.2	0.4	1.0	-0.2	0.4	-0.1	0.5	1.4	0.7	1.2	0.3
Respiratory disease	0.1	0.2	0.6	-0.2	-0.3	-0.4	0.8	-0.5	-0.2	0.6	0.4	0.1	0.8	-0.5	-0.5
Hand grip strength (left)	0.1	0.4	1.1	-0.1	0.1	-0.1	0.6	-1.0	-0.7	-1.0	0.5	-1.0	0.4	-0.5	0.2
Systolic blood pressure, automated reading	0.1	0.3	0.9	-0.5	-0.5	-0.1	-0.1	-1.0	-0.4	-0.7	0.2	0.9	-0.1	0.7	-0.3
Impedance of leg (right)	0.1	0.3	0.8	-0.5	-0.9	-0.4	-0.6	-0.5	0.2	-0.3	-0.5	0.4	-0.6	0.5	-0.6
Relative age voice broke	0.1	0.1	0.4	0.3	0.2	-0.0	0.5	-0.2	0.7	0.2	0.1	0.4	0.3	-0.3	-0.2
Age when periods started (menarche)	0.1	0.1	0.5	-0.6	-0.2	-0.1	-0.0	-0.7	-0.4	-0.0	0.6	0.0	0.3	0.2	-0.2
Sitting height	0.1	0.9	2.7	0.0	1.2	0.1	1.6	-0.1	-0.4	0.7	1.0	0.9	1.4	-0.9	1.0
Impedance of leg (left)	0.1	0.3	0.7	-0.8	-0.8	-0.6	-0.5	-0.8	-0.1	-0.4	-0.5	-0.0	-0.6	0.4	-0.7
Number of incorrect matches in round	0.1	0.1	0.5	0.3	-0.1	-0.3	0.2	-0.1	0.2	-0.7	-0.2	-0.2	-0.2	0.2	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	0.8	0.3	0.1	-0.3	0.5	0.0	-0.1	-0.2	0.5	-0.3	0.1	0.7
Impedance of arm (right)	0.1	0.6	1.6	-0.9	-1.0	0.1	-0.5	-0.2	0.9	0.4	-0.3	0.8	-0.5	1.1	-1.3
Impedance of arm (left)	0.1	0.7	2.6	-1.3	-1.4	-0.4	-0.5	-0.3	0.1	-0.3	-0.6	0.1	-0.6	0.4	-1.6
Length of working week for main job	0.1	0.1	0.2	0.4	-0.2	-0.3	0.1	0.0	-0.3	0.0	-0.0	-0.3	0.4	-0.1	0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	0.4	-0.4	-0.1	-0.9	0.4	0.1	-0.1	-0.2	-0.8	-0.5	-0.3	-0.6
Birth weight	0.1	0.2	0.8	0.2	0.5	0.4	0.7	0.3	0.1	0.3	0.6	0.2	0.7	0.4	0.9
Worry too long after embarrassment	0.1	0.2	0.9	-0.3	0.3	0.5	0.2	-0.5	-0.9	0.0	0.4	-0.7	0.1	0.3	0.0
Medication: Aspirin	0.1	0.1	0.5	0.4	0.2	0.3	0.7	0.2	0.4	-0.0	0.0	0.2	0.3	0.4	0.5
Loneliness, isolation	0.1	0.2	0.9	0.6	0.2	0.4	-0.4	0.1	-0.9	-0.7	-0.2	-0.1	-0.1	0.3	-0.3
Breast cancer (self-reported)	0.1	0.1	0.3	-0.3	0.1	0.1	0.4	-0.6	-0.4	-0.1	0.5	0.2	0.3	-0.1	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	-0.3	-0.3	0.1	0.4	0.0	0.8	0.5	0.3	0.8	0.2	0.1	0.1
Heart disease (siblings)	0.1	0.2	0.6	-0.6	0.2	-0.1	0.1	-0.5	0.2	-0.0	-0.0	-0.8	-0.2	0.7	-0.0
Impedance of whole body	0.1	0.4	1.2	-1.0	-0.8	-0.2	-0.5	-0.5	0.0	-0.1	-0.5	0.2	-0.5	0.6	-1.1
Hair Pigment	0.0	0.2	1.6	-1.2	-0.1	-0.2	0.1	-0.5	-0.8	-0.3	-0.2	-0.5	-0.1	0.0	0.0
Tanning	0.0	0.5	1.6	0.7	-0.3	0.3	0.4	-0.2	0.9	0.6	0.9	1.3	1.0	0.9	0.4
Standing height	0.0	0.4	1.6	0.1	1.0	0.4	0.8	1.3	-0.2	0.5	0.7	-0.2	0.6	-0.5	0.4

Hub : Genes

DNAH5

Models

Trait associations