Hub : Genes

DNAH7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1140	0.0280	1.5e-14	0.126	0.107	0.125	0.106	0.130	4.2e-15	5.4e-13	6.4e-15	7.6e-13	1.4e-15
2	NTR	Blood	0.0237	0.0082	3.3e-06	0.018	0.008	0.004	0.009	0.010	1.0e-06	8.8e-04	1.6e-02	6.1e-04	3.1e-04
3	ROSMAP	Brain Pre-frontal Cortex	0.1805	0.0385	0.0e+00	0.167	0.200	0.225	0.225	0.212	7.0e-21	4.0e-25	1.7e-28	1.8e-28	1.1e-26
4	TCGA	Breast Invasive Carcinoma	0.0357	0.0168	2.3e-06	0.014	0.023	0.022	NA	0.018	4.7e-04	1.4e-05	1.8e-05	NA	1.2e-04
5	TCGA	Glioblastoma Multiforme	0.1580	0.0870	2.9e-03	0.023	0.077	0.084	NA	0.016	6.5e-02	2.5e-03	1.6e-03	NA	1.1e-01
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0436	0.0224	9.0e-06	0.052	0.050	0.060	NA	0.063	1.5e-06	2.7e-06	2.7e-07	NA	1.4e-07
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0754	0.0367	1.8e-04	0.035	0.026	0.020	NA	0.027	6.7e-05	5.8e-04	2.5e-03	NA	4.5e-04
8	TCGA	Brain Lower Grade Glioma	0.0472	0.0257	1.6e-04	0.006	0.033	0.033	NA	0.021	5.5e-02	1.0e-04	1.1e-04	NA	1.6e-03
9	TCGA	Lung Squamous Cell Carcinoma	0.0342	0.0178	1.4e-04	0.046	0.031	0.030	NA	0.034	5.3e-06	1.8e-04	1.9e-04	NA	8.2e-05
10	TCGA	Pancreatic Adenocarcinoma	0.0770	0.0530	6.2e-03	0.046	0.047	0.024	NA	0.052	5.1e-03	4.9e-03	3.3e-02	NA	3.2e-03
11	TCGA	Prostate Adenocarcinoma	0.1540	0.0594	2.7e-14	0.113	0.146	0.152	NA	0.149	6.8e-12	4.7e-15	1.3e-15	NA	2.7e-15
12	TCGA	Thyroid Carcinoma	0.1510	0.0550	7.7e-14	0.167	0.140	0.102	NA	0.145	4.9e-16	1.5e-13	3.6e-10	NA	5.2e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.1	1.7	4.4	-0.7	-2.1	-1.4	1.4	-1.5	0.4	0.7	-1.9	1.1	1.6	0.6	1.0
Bipolar Disorder or Schizophrenia	2.7	6.6	16.2	-1.8	-2.4	-3.0	2.5	-2.5	1.1	2.3	-4.0	2.6	3.3	1.6	2.4
Depressed Affect (Nagel 2018)	0.8	1.6	4.6	-1.2	-1.2	-0.5	0.8	2.1	1.6	1.2	0.5	1.2	0.3	1.8	1.3
Depression (Nagel 2018)	0.9	1.4	6.7	-0.9	-1.0	-0.4	0.4	2.6	1.3	1.2	0.6	1.0	-0.2	1.4	1.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.4	-0.5	-1.1	-0.5	-0.6	0.4	0.5	1.2	-0.0	0.8	0.6	0.8	0.8
Neuroticism (Nagel 2018)	1.9	4.4	8.5	-2.4	-2.0	-1.7	1.3	2.1	2.7	2.3	-0.1	2.2	1.5	2.9	2.4
Schizophrenia (2018)	2.5	5.3	13.6	-1.7	-1.4	-2.8	2.1	-2.0	1.0	2.3	-3.7	2.5	2.9	1.5	2.3
Schizophrenia vs Biploar Disorder	0.2	0.3	1.4	-0.3	1.2	-0.6	-0.2	-0.4	-0.6	0.3	-1.0	0.3	0.1	-0.3	-0.0
Worry (Nagel 2018)	4.6	9.7	13.0	-3.5	-3.1	-3.2	2.8	0.4	3.5	3.3	-2.3	3.4	3.2	3.6	3.6
Alzheimer’s Disease (in mother)	1.2	1.4	5.5	1.1	0.6	-0.1	-0.3	-2.4	-1.4	-1.3	-0.5	-1.3	0.1	-1.8	-1.2
Alzheimer’s Disease (in father)	0.2	0.2	0.9	0.6	-0.3	0.1	0.5	-0.9	-0.1	-0.4	0.2	-0.3	-0.3	-0.7	-0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	5.6	0.9	-0.1	-0.3	0.3	-2.4	-0.8	-0.8	-0.5	-0.6	0.3	-1.4	-0.5
Crohns Disease (2017)	0.7	1.6	3.1	-1.3	-1.8	-1.2	1.5	0.2	1.5	1.4	-0.1	1.4	0.9	1.2	1.4
Irritable Bowel Disease (IBD)	0.4	1.0	3.6	-0.9	-1.7	-1.0	1.9	-0.3	1.2	0.5	-0.2	0.8	0.6	0.3	0.7
Ulcerative Colitis (UC)	0.2	0.3	1.3	-0.1	-0.7	-0.5	1.1	-0.8	0.2	-0.5	-0.6	-0.1	0.2	-0.8	-0.2
Major Depression (MDD)	1.9	2.3	4.0	-1.3	-1.0	-1.5	1.4	-0.3	1.5	1.9	-1.6	2.0	1.5	1.5	1.9
Reaction Time	0.3	0.5	1.6	0.8	0.7	-0.3	0.1	0.7	-1.2	-0.3	0.2	-0.1	-1.3	-0.9	-0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.7	-0.7	-1.1	-0.3	0.4	0.2	0.9	0.7	0.2	0.6	0.5	1.3	0.9
Breast Cancer	0.1	0.2	0.9	0.0	0.0	-0.7	-0.2	-0.9	-0.6	0.4	-0.5	-0.1	0.2	-0.1	-0.0
Ovarian Cancer	0.2	0.3	0.7	-0.3	0.1	0.7	-0.2	0.5	0.7	0.4	0.9	0.2	-0.6	0.6	0.2
Prostate Cancer	0.7	0.9	3.7	-0.4	-0.4	-1.7	0.2	-1.9	-0.4	0.4	-1.7	0.4	0.7	-0.5	0.1
Age at First Birth	0.3	0.5	1.3	-0.7	-0.3	-1.2	1.1	-0.1	0.4	0.6	-0.4	0.6	-0.0	0.9	0.8
Bipolar Disorder (2011)	8.3	8.0	10.7	-2.9	-3.3	-3.1	2.9	-1.0	2.0	2.7	-3.2	3.0	3.3	2.7	3.0
Body Mass Index (BMI) (2010)	2.0	2.7	5.0	-2.0	-1.8	-0.9	1.5	0.8	2.2	1.7	-1.1	1.8	1.6	2.0	1.8
Coronary Artery Disease (CAD)	0.2	0.2	1.1	-0.8	-0.0	0.5	0.2	0.6	1.1	0.2	0.1	-0.1	-0.1	0.7	-0.1
Crohns Disease (2012)	1.5	2.4	3.7	-1.8	-1.8	-1.5	1.5	1.9	1.4	1.6	0.1	1.8	0.7	1.6	1.7
Mean Putamen Volume	0.1	0.1	0.6	0.4	0.4	0.8	-0.1	-0.4	-0.3	-0.2	0.3	-0.3	-0.3	-0.2	-0.1
Fasting Glucose	0.3	0.3	0.8	-0.6	-0.9	-0.3	0.8	0.4	0.8	0.5	0.8	0.2	-0.5	0.1	0.3
HbA1C	0.1	0.1	0.8	-0.1	0.9	-0.1	-0.2	0.5	0.2	0.1	-0.1	0.1	0.4	0.4	0.1
HDL Cholesterol	0.3	0.4	0.9	0.6	1.0	0.8	-0.7	0.2	-0.6	-0.6	0.8	-0.3	-0.9	-0.2	-0.5
LDL Cholesterol	0.3	0.4	0.9	0.3	0.6	0.3	-0.5	-0.7	-0.4	-0.8	-0.2	-0.9	-0.2	-1.0	-0.8
Lupus	1.0	1.5	3.9	-1.4	-1.6	-0.4	0.7	1.4	2.0	1.4	0.3	1.2	0.4	1.4	1.2
Neuroticism (2016)	2.1	3.0	5.4	-2.0	-1.3	-1.1	1.5	1.3	2.3	2.1	-0.3	1.9	1.4	2.3	2.2
Primary Biliary Cirrhosis	0.1	0.1	0.7	0.5	0.2	-0.0	-0.5	-0.1	-0.8	-0.1	-0.2	-0.1	-0.1	-0.3	-0.2
Rheumatoid Arthritis	0.3	0.4	2.2	-0.4	0.6	0.6	-0.7	1.5	0.8	0.3	0.6	0.2	-0.4	0.4	0.1
Schizophrenia (2014)	2.0	4.5	10.2	-1.9	-1.6	-2.6	2.1	-0.8	0.9	2.3	-3.2	2.5	2.3	1.6	2.2
Triglycerides	0.2	0.3	1.6	-0.6	-0.7	-0.2	0.5	0.2	1.2	0.5	-0.7	0.1	0.7	0.4	0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.0	0.8	-0.0	1.2	-0.7	0.3	-0.8	-1.4	1.1	-1.4	-0.7	-1.3	-1.3
Ulcerative Colitis	0.6	0.9	3.0	-0.9	-1.7	-1.4	1.4	0.0	0.6	0.5	-0.5	0.9	0.3	0.5	0.8
Blood Eosinophil Count	2.7	20.6	36.5	-4.5	-4.0	-4.2	6.0	-0.9	4.5	4.1	-5.0	5.0	4.4	4.9	5.2
Blood Platelet Count	0.1	0.9	6.2	0.5	2.5	0.8	-1.1	-0.4	-0.5	-0.7	-0.3	-0.5	0.2	-0.3	-0.7
Blood Red Count	0.4	3.5	8.6	-1.7	-2.9	-2.1	1.5	-2.4	1.8	1.9	-1.4	1.3	2.3	0.9	1.4
Blood White Count	0.0	0.3	1.0	0.2	1.0	0.1	-0.7	-0.1	-0.1	-0.4	0.1	-0.6	-0.1	-0.8	-0.6
Heel T-Score	3.1	24.7	42.9	4.7	4.5	5.3	-5.2	3.3	-4.0	-4.5	6.3	-5.0	-6.5	-4.3	-5.2
BMI	0.4	2.2	3.9	1.7	1.5	2.0	-1.0	-0.1	-1.4	-1.9	-0.1	-1.6	-1.3	-1.8	-1.7
Height	0.1	1.9	3.8	1.2	1.2	-0.0	-1.9	-1.9	-1.6	-1.2	-0.2	-1.6	0.2	-2.0	-1.6
Waist Hip Ratio (WHR)	0.3	1.6	3.1	1.1	0.9	1.6	-1.7	-0.8	-0.8	-1.5	0.4	-1.8	-0.2	-1.2	-1.6
Systolic Blood Pressure	1.0	5.2	9.7	2.3	2.6	1.9	-3.1	-0.4	-2.3	-2.3	1.3	-2.8	-0.9	-2.8	-2.8
Smoking Status	2.5	6.0	10.8	3.3	2.1	2.0	-1.8	0.1	-3.0	-2.9	1.5	-2.7	-2.6	-2.8	-2.8
Allergy or Eczema	2.4	6.4	8.7	-3.0	-2.4	-2.5	2.3	-0.9	2.8	2.7	-2.4	2.6	2.8	2.7	2.7
Cardiovascular Disease	0.8	2.6	5.2	1.2	1.7	2.3	-1.2	1.6	-0.2	-1.6	2.2	-1.5	-2.2	-0.9	-1.5
Hypothyroidism (self reported)	0.3	0.6	2.3	-0.6	-0.9	-0.6	0.7	1.5	0.2	0.7	0.2	0.9	-0.1	0.8	0.9
Respiratory disease	0.7	1.5	2.8	-1.1	-1.5	-1.1	0.6	0.2	0.7	1.5	-1.4	1.5	0.9	1.7	1.5
Type 2 Diabetes (T2D) (2018)	4.9	9.1	15.8	3.4	3.4	2.7	-4.0	0.9	-3.4	-2.8	1.8	-3.1	-2.9	-3.2	-3.4
Lung FEV1/FVC ratio	0.3	1.4	2.8	1.4	1.2	1.0	-0.9	1.2	-1.0	-1.0	1.7	-1.1	-0.9	-1.5	-1.2
Lung FVC	0.2	0.9	2.3	1.1	0.5	1.0	-0.7	-0.6	-0.8	-0.9	0.9	-1.1	-0.7	-1.5	-1.2
Neuroticism	1.4	3.3	7.5	-2.0	-1.6	-1.4	1.7	1.2	2.7	1.8	-0.4	1.8	1.6	2.3	2.1
Chronotype (morning person)	0.5	1.2	6.2	-0.9	-0.9	-0.9	1.3	-2.5	0.6	0.4	-1.4	0.5	1.1	0.2	0.6
Hair Pigment	0.4	12.3	16.4	3.8	3.7	4.0	-3.3	0.8	-3.3	-3.9	3.3	-3.9	-3.3	-3.5	-4.0
Tanning	0.1	1.6	2.8	1.3	1.2	1.0	-1.7	-0.3	-1.6	-1.2	0.6	-1.3	-1.3	-1.4	-1.5
Hand grip strength (left)	0.7	1.8	4.7	1.2	0.8	0.6	-1.6	-2.2	-1.3	-1.2	-0.3	-1.6	0.6	-1.8	-1.6
Number of treatments/medications taken	0.5	0.9	2.9	-0.7	-0.4	-0.7	1.0	-0.8	1.1	0.6	-1.7	0.6	1.4	0.6	0.6
Average weekly spirits intake	1.2	1.5	5.4	1.1	2.3	1.3	-1.4	0.4	-1.1	-1.0	0.4	-1.0	-0.8	-1.2	-1.2
Sensitivity / hurt feelings	1.4	2.5	4.4	-1.7	-1.9	-1.9	1.1	-0.9	1.7	1.6	-1.7	1.3	2.1	1.0	1.4
Frequency of depressed mood in last 2 weeks	2.8	3.9	6.7	-2.3	-1.9	-1.7	1.2	2.0	2.3	2.6	-0.7	2.3	1.1	2.4	2.2
Hearing difficulty/problems: Yes	2.9	4.4	7.1	-1.9	-2.1	-2.4	0.9	-1.3	1.4	2.7	-2.6	2.2	2.6	2.1	2.2
Relative age of first facial hair	2.2	4.6	7.5	2.6	1.4	2.4	-1.3	0.8	-2.2	-2.7	1.9	-2.5	-2.2	-2.4	-2.4
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	4.6	-1.9	-1.3	-1.2	1.1	1.4	1.7	2.0	-0.6	2.0	1.4	2.1	2.0
Ever used hormone-replacement therapy (HRT)	1.8	2.4	3.4	-1.4	-1.4	-1.6	1.0	-1.4	1.1	1.7	-1.8	1.6	1.9	1.7	1.7
Ever had hysterectomy (womb removed)	0.2	0.3	0.7	0.6	-0.1	0.7	-0.4	0.4	-0.3	-0.6	0.6	-0.5	-0.9	-0.2	-0.4
Systolic blood pressure, automated reading	2.1	6.0	9.6	2.6	3.1	2.0	-2.7	-1.5	-2.6	-2.7	0.7	-2.8	-0.9	-3.1	-3.0
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.8	1.1	1.2	0.8	-1.2	-1.4	-1.3	-1.2	-0.2	-1.3	-0.1	-0.9	-1.2
Angina	1.3	1.7	3.9	-1.0	-1.3	-1.6	1.0	-0.9	1.2	1.3	-2.0	1.1	1.8	0.8	1.2
Medication for hormone replacement therapy	0.1	0.2	0.5	-0.3	-0.2	-0.1	-0.6	-0.0	0.2	0.7	-0.1	0.4	0.3	0.7	0.3
Vitamin and mineral supplements	3.2	4.4	8.3	2.2	2.9	1.9	-2.6	-0.8	-2.4	-2.2	0.8	-2.2	-1.5	-2.3	-2.3
Supplements: Zinc	3.0	3.3	10.6	1.2	1.0	1.5	-1.2	3.0	-1.2	-1.0	3.3	-1.1	-2.8	-0.6	-1.2
Medication: Co-codamol	0.2	0.2	0.6	0.4	0.8	0.2	-0.5	-0.1	-0.7	-0.4	-0.5	-0.3	-0.2	-0.6	-0.5
Medication: Metformin	3.0	4.3	6.1	2.4	2.4	1.8	-2.4	0.6	-2.5	-2.1	0.8	-2.2	-2.0	-2.2	-2.3
Diabetes (father)	2.0	2.5	6.5	1.1	0.8	1.4	-1.3	2.5	-1.2	-1.5	2.1	-1.5	-2.0	-1.3	-1.3
Diabetes (mother)	1.7	2.2	7.2	1.2	1.6	1.2	-2.7	-0.0	-1.5	-0.8	1.3	-1.4	-1.8	-1.2	-1.6
Severe depression (siblings)	0.1	0.1	0.4	-0.2	0.3	0.4	0.1	0.5	0.2	-0.3	0.7	-0.3	-0.1	-0.2	-0.2
Pack years adult smoking proportion	0.1	0.2	0.6	-0.4	0.5	-0.1	0.0	0.8	0.1	0.2	-0.7	0.4	0.3	0.6	0.5
Impedance of leg (right)	0.1	0.3	1.2	0.3	0.1	0.7	-0.4	0.4	-0.0	-0.5	1.1	-0.7	-0.1	0.1	-0.4
Leg fat-free mass (left)	0.0	0.2	0.6	0.4	0.8	0.0	-0.5	-0.2	-0.7	-0.2	-0.6	-0.1	-0.3	-0.6	-0.3
Trunk fat percentage	0.9	3.6	6.9	2.2	2.4	1.7	-1.1	-0.6	-2.2	-2.6	-0.4	-2.1	-1.4	-2.2	-2.2
Hand grip strength (right)	1.0	2.8	4.5	1.6	1.3	1.6	-2.1	-1.7	-1.5	-1.8	0.9	-2.1	-0.4	-2.0	-2.1
Townsend deprivation index at recruitment	3.3	4.7	7.9	2.3	2.7	1.5	-2.8	0.3	-2.6	-2.0	1.2	-2.2	-1.7	-2.8	-2.4
Current tobacco smoking	6.4	10.5	15.3	3.9	3.3	3.4	-2.4	1.3	-3.6	-3.8	2.3	-3.5	-3.4	-3.5	-3.6
Average weekly fortified wine intake	0.3	0.4	1.3	-0.6	-0.7	-0.7	1.2	-0.3	0.3	0.4	-0.6	0.6	0.4	0.6	0.7
Maternal smoking around birth	6.0	8.6	12.2	3.5	2.7	3.0	-2.9	0.1	-3.0	-3.4	2.4	-3.4	-2.7	-3.1	-3.4
Fed-up feelings	0.3	0.5	2.4	0.2	0.5	0.5	-0.8	1.6	-0.2	0.2	1.2	0.0	-0.9	0.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	7.3	-0.6	-0.4	0.2	-0.0	2.7	1.3	1.1	1.2	0.8	-0.4	1.3	0.8
Relative age voice broke	0.9	1.3	2.3	1.3	0.5	0.8	-0.7	0.2	-1.4	-1.4	1.0	-1.5	-1.1	-1.5	-1.4
Taking other prescription medications	1.1	1.7	3.4	-1.5	-1.0	-0.9	1.0	1.0	1.5	1.4	-0.8	1.4	1.4	1.8	1.4
Age when periods started (menarche)	1.9	4.6	7.1	-2.3	-2.7	-2.6	2.1	-1.6	1.9	1.8	-2.7	1.8	2.5	1.4	1.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	-0.2	-0.6	-0.9	0.3	-0.8	-0.4	0.8	-1.0	0.6	1.1	0.6	0.6
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.3	10.5	1.9	2.4	2.9	-1.6	1.8	-0.9	-2.4	3.2	-2.3	-3.2	-1.7	-2.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.9	-0.7	-0.3	-0.6	0.9	-0.6	0.9	0.7	-0.4	0.6	1.0	0.7	0.7
Qualifications: CSEs or equivalent	0.4	0.5	1.2	-0.8	0.0	-0.3	0.1	-0.1	1.1	0.8	-0.5	0.8	0.9	1.1	0.7
Serious illness, injury or assault to yourself	2.4	2.9	5.3	-2.1	-2.1	-1.3	1.4	-0.3	2.3	1.8	-0.6	1.7	1.3	2.3	1.8
High blood pressure	0.4	1.0	2.9	0.8	1.7	1.6	-0.2	-0.0	0.2	-1.4	0.8	-1.1	-0.6	-0.8	-1.1
Hayfever, allergic rhinitis or eczema	2.3	5.1	7.6	-2.5	-1.9	-2.4	1.9	-0.8	2.3	2.4	-2.4	2.2	2.8	2.3	2.4
Multivitamins +/- minerals	2.5	3.2	4.4	-1.9	-2.0	-1.4	1.9	1.8	2.1	2.1	-0.2	2.1	0.4	2.0	2.1
Stomach or abdominal pain in last month	0.1	0.1	0.6	-0.0	0.8	0.4	-0.4	0.3	0.4	-0.1	0.6	-0.1	-0.2	0.4	-0.2
Supplements: Glucosamine	0.3	0.4	1.9	-0.2	0.0	0.3	0.8	1.4	0.8	-0.1	0.6	0.2	-0.8	0.3	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.3	-0.7	0.5	-0.3	0.1	-0.5	0.2	0.4	-1.1	0.3	1.0	0.4	0.3
Medication: Atenolol	0.3	0.4	1.3	-0.2	-0.5	-0.8	0.2	-1.1	0.2	0.5	-0.9	0.3	0.9	0.6	0.4
Medication: Levothyroxine sodium	0.3	0.4	1.3	-0.6	-0.1	-0.9	0.4	1.1	-0.1	0.8	-0.2	1.0	-0.0	0.5	0.8
Sitting height	0.5	3.9	6.2	-2.5	-2.4	-1.7	1.9	-0.2	2.5	2.0	-1.3	1.8	1.7	2.4	2.1
Chronic bronchitis/emphysema (father)	1.1	1.2	6.9	-0.7	0.4	0.8	-0.4	2.6	0.8	0.4	1.4	0.4	-1.3	1.4	0.4
High blood pressure (mother)	0.8	1.2	5.5	-0.8	-0.7	0.4	0.9	2.3	1.6	0.5	1.0	0.7	-0.7	1.1	0.6
Body mass index (BMI)	0.9	3.7	6.2	2.2	2.4	2.2	-1.4	0.0	-1.9	-2.5	0.2	-2.1	-1.7	-2.3	-2.3
Impedance of leg (left)	0.2	0.9	1.8	1.0	0.6	1.2	-0.9	0.0	-0.6	-1.2	1.2	-1.3	-0.6	-0.6	-1.1
Leg predicted mass (left)	0.0	0.2	0.7	0.4	0.8	0.0	-0.6	-0.2	-0.7	-0.2	-0.6	-0.2	-0.3	-0.6	-0.4
Trunk fat mass	0.8	3.2	6.0	2.1	2.3	1.7	-1.2	-0.4	-1.9	-2.5	-0.2	-2.0	-1.4	-2.1	-2.1
Waist circumference	1.1	3.9	6.8	2.2	2.2	2.1	-1.6	-0.8	-1.9	-2.6	0.2	-2.4	-1.4	-2.3	-2.4
Number of incorrect matches in round	0.8	1.4	3.2	-1.0	0.5	-1.6	0.9	-0.3	0.2	1.5	-1.8	1.7	1.2	0.9	1.4
Past tobacco smoking	1.2	2.1	4.2	-2.0	-1.4	-0.8	1.1	1.4	1.6	1.7	0.1	1.6	0.8	2.1	1.7
Alcohol usually taken with meals	3.9	6.4	9.8	-2.6	-2.5	-3.1	2.8	-1.5	1.9	2.6	-2.6	2.7	2.6	2.2	2.8
Nervous feelings	1.8	3.3	4.9	-1.9	-1.9	-1.8	1.6	0.1	2.1	2.0	-1.1	2.0	1.8	2.2	2.2
Frequency of tenseness / restlessness in last 2 weeks	3.7	5.7	8.6	-2.6	-2.4	-1.9	1.9	1.4	2.8	2.9	-1.1	2.9	2.0	2.9	2.9
Hearing difficulty/problems with background noise	1.4	2.2	4.0	-1.6	-2.0	-1.4	0.5	0.7	1.8	2.0	-0.2	1.6	1.1	1.9	1.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	-0.6	-0.6	-0.5	0.7	0.5	0.5	0.6	-0.4	0.8	0.1	0.8	0.9
Had menopause	0.3	0.3	1.2	-0.2	-0.1	-0.8	-0.3	-1.0	-0.4	0.4	-1.1	0.3	0.6	-0.1	0.1
Had other major operations	0.4	0.5	1.2	-0.5	-0.4	-0.8	0.3	0.9	-0.1	1.0	-0.5	1.1	0.2	1.0	1.0
Forced vital capacity (FVC)	0.5	1.8	3.2	1.4	1.0	1.3	-1.8	-1.2	-1.2	-1.3	1.0	-1.8	-0.3	-1.3	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	7.2	1.2	2.1	2.3	-1.9	2.3	-0.6	-1.5	2.7	-1.6	-2.7	-1.0	-1.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.4	-1.3	-0.5	-0.9	1.1	0.8	1.3	1.1	-0.8	1.2	1.1	1.5	1.4
Qualifications: None of the above	0.0	0.1	0.2	-0.1	-0.2	0.5	0.3	0.3	0.3	-0.1	0.2	-0.0	-0.2	0.4	0.1
Financial difficulties in last 2 years	1.0	1.4	4.5	0.5	1.0	1.7	-0.5	2.1	0.2	-0.6	2.0	-0.5	-1.7	-0.1	-0.6
Mouth/teeth dental problems	0.3	0.5	1.2	-0.5	-0.5	-0.9	0.7	-1.1	-0.2	0.6	-1.1	0.5	0.8	0.7	0.6
Heart attack	2.3	2.9	7.0	-2.0	-2.0	-0.9	1.4	0.6	2.6	1.5	-0.6	1.5	1.8	2.4	1.8
Allergy	1.8	4.2	6.1	2.1	1.9	2.2	-2.0	1.2	-2.2	-2.0	2.2	-2.0	-2.5	-2.1	-2.2
Pain all over the body in last month	1.2	1.3	4.4	0.7	1.2	-0.2	-1.5	-1.2	-2.1	-0.9	-0.8	-1.1	0.1	-1.3	-1.2
Diabetes (self-reported)	3.5	5.4	8.7	2.6	2.7	2.4	-3.0	0.9	-2.6	-2.3	1.4	-2.4	-2.3	-2.0	-2.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	0.1	0.2	-0.2	0.0	0.2	-0.7	-0.2	-0.5	-0.0	-0.1	-0.3	-0.1
Medication: Ramipril	2.0	2.5	4.9	1.6	1.9	1.5	-2.2	-0.2	-1.6	-1.7	0.7	-1.9	-1.2	-1.7	-1.9
Medication: Simvastatin	1.1	1.7	3.1	1.6	1.4	0.6	-1.4	-1.5	-1.5	-1.2	-0.5	-1.4	0.0	-1.8	-1.4
Fluid intelligence score	0.5	1.1	3.3	-1.1	-1.8	-0.8	0.2	0.3	1.0	1.4	0.0	1.1	0.7	1.3	1.2
Illnesses of siblings	0.2	0.2	0.7	0.7	-0.1	-0.2	-0.5	-0.7	-0.8	0.1	-0.6	-0.1	0.7	-0.2	-0.1
Neuroticism score	1.2	2.6	5.4	-1.7	-1.7	-1.2	1.7	0.6	2.3	1.5	-0.6	1.4	1.8	2.0	1.8
Weight	0.8	3.8	5.8	2.2	2.3	2.0	-1.7	-0.3	-2.0	-2.4	0.4	-2.2	-1.5	-2.3	-2.3
Impedance of arm (right)	0.2	1.0	2.1	-1.0	-1.0	-1.4	0.7	0.6	0.6	1.2	-0.2	1.1	0.4	1.4	1.2
Arm fat percentage (right)	0.5	1.8	3.7	1.6	1.9	1.6	-0.7	0.4	-1.2	-1.8	-0.1	-1.3	-1.2	-1.4	-1.5
Trunk fat-free mass	0.0	0.1	0.3	0.2	0.4	0.4	-0.5	-0.1	-0.1	-0.2	0.0	-0.3	-0.1	-0.5	-0.4
Hip circumference	0.5	2.1	3.2	1.8	1.7	1.4	-1.1	-0.1	-1.5	-1.8	0.3	-1.6	-1.4	-1.7	-1.7
Time employed in main current job	0.9	1.0	2.8	1.1	0.0	-0.1	0.4	-1.2	-0.9	-1.5	-0.2	-1.3	0.1	-1.7	-1.2
Alcohol intake versus 10 years previously	1.4	2.1	6.0	1.5	1.0	1.4	-1.0	1.2	-1.9	-1.4	1.3	-1.1	-2.4	-1.4	-1.3
Father’s age at death	1.0	1.3	3.1	-1.5	-1.4	-0.2	1.0	1.0	1.8	1.1	-0.1	1.1	0.4	1.7	1.3
Worrier / anxious feelings	3.5	6.7	9.5	-3.1	-2.4	-2.5	2.4	0.3	3.1	2.9	-2.0	2.8	2.3	3.0	3.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	7.3	-0.6	0.3	0.1	-0.1	2.7	0.9	0.6	1.0	0.5	-0.5	0.9	0.5
Falls in the last year	0.2	0.2	1.4	0.3	-0.1	0.4	-0.0	-0.4	-0.1	-0.2	0.9	-0.2	-1.2	-0.5	-0.3
Hair/balding pattern: Pattern 3	1.4	2.1	5.4	1.0	1.0	1.5	-0.7	1.6	-0.6	-1.4	2.3	-1.2	-2.2	-1.1	-1.3
Number of live births	1.0	1.4	2.6	1.4	1.6	1.3	-1.1	-0.0	-0.9	-1.3	0.8	-1.2	-1.2	-1.4	-1.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	3.5	1.7	1.3	1.3	-1.8	-0.8	-1.6	-1.5	1.2	-1.9	-0.4	-1.7	-1.8
Pulse rate	0.5	0.8	2.0	0.9	1.0	1.2	0.2	-1.4	-0.6	-1.3	-0.1	-0.9	0.1	-0.7	-0.7
Happiness	2.6	3.1	5.5	-2.1	-0.9	-1.8	1.0	0.8	1.6	2.3	-1.3	2.2	1.7	2.3	2.1
Noisy workplace	0.9	1.1	6.7	1.0	0.3	-0.1	0.0	-2.6	-0.4	-0.9	-0.9	-1.0	0.9	-1.1	-0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.5	1.0	1.2	0.5	-1.1	-0.7	-1.1	-0.5	0.5	-0.6	-0.7	-0.6	-0.6
Serious illness, injury or assault of a close relative in last 2 years	4.3	4.9	9.7	-2.6	-2.0	-1.5	1.6	0.5	2.7	2.3	-1.5	2.2	2.7	3.1	2.5
Mouth/teeth dental problems: Dentures	1.1	1.8	3.0	1.7	1.4	1.5	-0.7	0.4	-1.3	-1.6	1.0	-1.3	-1.7	-1.6	-1.4
Asthma	1.7	3.3	4.6	-1.8	-2.1	-1.9	1.4	-0.6	1.9	1.9	-2.1	1.8	1.9	2.0	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.8	0.2	-0.0	0.2	-0.6	0.9	0.2	-0.2	0.5	-0.5	0.1	-0.3	-0.4
Medication: Cholesterol lowering	1.1	1.8	7.7	-0.8	-0.2	-1.3	0.6	-1.8	0.8	1.0	-2.8	0.9	2.1	0.4	0.7
Depression (self-reported)	2.1	2.5	4.7	-1.8	-1.7	-1.5	1.0	1.2	2.2	2.0	-0.6	1.7	1.3	1.5	1.6
Medication: Lansoprazole	0.5	0.5	1.7	-0.8	-0.3	-1.0	0.2	-0.2	0.4	0.8	-1.3	0.7	0.7	0.8	0.6
Prospective memory result	0.1	0.1	0.4	-0.3	0.6	-0.5	-0.4	-0.6	-0.1	0.2	-0.1	-0.0	-0.1	0.1	-0.1
Lung cancer (father)	0.2	0.2	0.8	-0.3	-0.4	-0.6	-0.9	0.2	-0.3	0.7	-0.3	0.3	0.4	0.3	0.2
Illnesses of mother	0.1	0.1	0.5	0.0	-0.1	-0.4	0.1	-0.7	-0.3	0.3	-0.4	0.3	0.3	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.1	1.2	0.8	0.7	-1.4	-0.4	-1.3	-0.8	0.8	-1.2	-0.1	-1.4	-1.3
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	-0.3	-0.8	-0.7	0.8	0.1	0.3	0.5	-0.8	0.7	0.6	0.9	0.7
Impedance of arm (left)	0.0	0.2	0.6	-0.4	-0.6	-0.8	0.3	0.3	0.1	0.5	0.4	0.4	0.0	0.7	0.5
Arm fat mass (right)	0.7	2.9	5.3	1.9	2.3	1.9	-1.3	0.1	-1.7	-2.2	-0.0	-1.8	-1.4	-1.9	-2.0
Trunk predicted mass	0.0	0.1	0.3	0.3	0.5	0.4	-0.6	-0.1	-0.1	-0.2	0.1	-0.4	-0.2	-0.6	-0.4
Standing height	0.0	0.2	0.8	0.1	0.0	-0.3	-0.8	-0.9	-0.3	-0.1	0.2	-0.5	0.4	-0.3	-0.4
Length of working week for main job	0.2	0.2	1.0	-0.2	0.4	-0.6	-1.0	0.3	-0.3	0.7	-0.2	0.4	0.2	0.2	0.2
Exposure to tobacco smoke at home	0.8	0.9	2.1	0.8	1.0	1.3	-0.4	1.3	-0.6	-1.0	1.1	-0.8	-1.4	-0.4	-0.7
Breastfed as a baby	0.3	0.3	1.0	0.6	0.2	0.7	-1.0	0.4	-0.1	-0.3	1.0	-0.5	-0.6	-0.4	-0.5
Tense / ‘highly strung’	7.1	11.7	15.1	-3.7	-3.4	-3.7	3.6	0.7	3.8	3.7	-2.7	3.8	3.4	3.4	3.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.5	6.4	-2.4	-1.7	-2.5	2.1	-1.1	2.2	2.3	-2.4	2.1	2.5	1.7	2.1
Hair/balding pattern: Pattern 4	0.7	1.8	2.9	-1.3	-1.6	-1.4	1.0	-0.6	1.6	1.6	-1.0	1.3	1.7	1.1	1.3
Birth weight of first child	2.9	5.3	7.5	-2.6	-2.2	-2.3	2.2	-0.5	2.2	2.7	-2.2	2.6	2.3	2.4	2.7
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.4	-0.7	-0.6	0.2	0.2	0.4	0.7	-0.3	0.5	0.6	0.4	0.6
Pulse wave reflection index	1.4	1.7	3.1	-1.1	-1.4	-1.8	1.1	1.2	1.0	1.7	-0.4	1.6	0.7	1.6	1.5
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.0	-1.4	-0.4	-0.6	0.7	0.8	1.7	1.3	-0.3	1.3	0.7	1.5	1.3
Loud music exposure frequency	0.4	0.4	2.1	-0.2	-1.0	0.0	-0.2	1.4	0.9	0.4	0.8	0.1	0.4	0.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.6	0.7	0.5	0.8	-1.2	-0.2	-0.4	-0.9	1.3	-1.2	-0.6	-1.1	-1.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.7	-0.7	-0.3	-0.3	-0.4	0.0	0.8	0.5	0.0	0.2	0.4	0.1	0.1
Blood clot in the leg (DVT)	0.6	0.8	1.6	1.2	0.8	0.6	0.1	-0.4	-0.8	-1.1	1.0	-1.0	-1.0	-1.2	-0.9
Medication: Paracetamol	0.9	1.5	3.9	1.1	0.9	1.3	-0.7	2.0	-0.7	-1.3	1.1	-1.0	-1.9	-0.9	-1.1
Headache pain in last month	0.2	0.3	1.7	-0.5	-0.5	0.3	0.1	1.3	0.5	0.6	0.1	0.6	0.2	0.7	0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	5.2	0.5	0.1	0.8	-0.9	2.0	-0.8	-0.4	2.3	-0.4	-1.6	-0.3	-0.4
Glaucoma (self-reported)	0.3	0.3	0.9	-0.3	0.6	0.1	-0.7	0.8	-0.2	0.4	1.0	0.2	-0.9	0.1	-0.1
Gout (self-reported)	2.8	3.8	6.9	2.3	2.6	2.0	-2.2	0.4	-2.1	-2.0	1.2	-2.0	-1.6	-1.8	-2.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	5.6	-1.1	-1.1	-0.6	1.1	2.4	0.8	0.9	0.6	1.2	-0.2	1.1	1.1
Medication: Amlodipine	0.3	0.4	1.8	0.7	1.4	0.2	-1.0	-0.1	-0.7	-0.2	-0.4	-0.3	-0.6	-0.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	0.4	0.9	0.5	-0.8	0.4	-0.8	-0.4	-0.1	-0.4	-0.4	-0.2	-0.3
Birth weight	3.2	7.0	10.5	-2.8	-3.0	-2.5	3.2	-0.1	2.2	2.9	-2.1	3.0	2.0	3.0	3.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	0.2	0.3	0.2	-0.7	0.6	-0.1	-0.1	-0.1	-0.2	0.0	0.0	-0.2
High blood pressure (siblings)	1.3	1.8	7.2	-2.0	-0.7	-0.2	1.9	-0.2	2.7	0.7	-0.5	1.0	0.8	1.5	1.2
Forced vital capacity (FVC), Best measure	0.2	0.7	1.5	0.9	0.6	0.5	-1.2	-0.7	-1.0	-0.7	0.5	-1.1	-0.1	-1.2	-1.1
Body fat percentage	1.1	4.2	8.3	2.4	2.5	2.1	-1.2	-0.3	-2.0	-2.9	0.0	-2.4	-1.5	-2.3	-2.4
Leg fat percentage (right)	1.2	4.5	8.6	2.4	2.5	2.7	-1.6	0.1	-1.7	-2.9	0.8	-2.5	-1.6	-2.1	-2.5
Arm fat-free mass (right)	0.2	0.9	1.8	1.1	1.1	1.0	-0.9	-0.6	-0.9	-1.1	0.1	-1.1	-0.5	-1.3	-1.2
Exposure to tobacco smoke outside home	2.4	3.2	4.9	2.1	2.2	2.0	-2.1	0.2	-1.6	-1.9	1.4	-1.9	-1.5	-1.6	-1.9
Comparative body size at age 10	0.2	0.7	1.2	-0.9	-0.9	-1.1	0.1	-0.5	0.9	1.0	-0.6	0.7	0.9	0.7	0.7
Number of full brothers	0.4	0.5	2.4	-0.5	-0.7	0.5	0.3	1.5	1.2	0.2	0.9	0.2	-0.3	0.2	0.2
Worry too long after embarrassment	0.8	1.3	6.0	0.5	0.1	0.9	-1.5	2.4	0.1	0.1	2.2	-0.3	-1.0	0.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	4.5	-1.9	-1.6	-1.9	1.5	0.3	2.1	2.1	-1.2	1.8	1.7	1.7	1.7
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	-0.2	-0.4	0.3	0.6	0.3	0.6	-0.2	-0.5	0.0	-0.1	0.5	0.2
Number of children fathered	0.4	0.4	0.9	0.6	0.5	0.6	-0.1	-0.6	-0.6	-1.0	-0.9	-0.7	0.2	-0.8	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.9	-0.1	0.4	0.3	-0.0	1.1	-0.0	0.0	1.0	0.2	-1.4	0.0	0.1
Age at first live birth	1.7	3.0	4.6	-2.1	-2.0	-1.7	2.0	0.2	1.7	1.8	-0.9	1.9	0.8	2.2	2.1
Pulse wave peak to peak time	0.3	0.3	0.9	0.2	0.6	0.6	-0.8	-0.1	-0.2	-0.4	0.7	-0.7	-0.5	-0.9	-0.7
Health satisfaction	0.2	0.2	0.6	0.3	0.8	0.5	-0.7	0.4	-0.5	-0.5	0.1	-0.4	-0.3	-0.2	-0.5
Shortness of breath walking on level ground	0.2	0.3	1.9	0.1	-0.7	-0.4	0.3	-1.4	-0.0	-0.2	-0.6	-0.2	0.2	-0.0	0.0
Qualifications: College or University degree	1.8	5.7	10.2	-2.4	-1.9	-3.2	2.5	-1.3	1.8	2.7	-2.4	2.7	2.4	2.1	2.7
Eye problems/disorders: None of the above	1.2	1.4	6.6	0.4	-0.2	1.4	0.6	2.6	0.6	-1.0	2.1	-0.6	-1.4	-0.1	-0.4
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.7	1.2	1.6	1.2	-0.6	0.7	-1.0	-1.4	1.1	-1.1	-1.3	-1.1	-1.1
Emphysema/chronic bronchitis	0.2	0.3	1.5	-0.6	0.0	-0.3	0.3	0.4	0.5	0.4	0.2	0.6	-0.0	1.2	0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	0.6	0.7	0.3	-0.4	-0.7	-0.9	-0.4	0.3	-0.4	-0.2	-0.4	-0.4
Neck or shoulder pain in last month	0.2	0.2	0.5	0.1	0.5	0.5	0.7	0.1	0.5	-0.7	0.4	-0.5	-0.0	-0.3	-0.4
Medication: Blood pressure	0.2	0.4	1.9	0.2	0.4	0.1	-0.0	-1.4	0.4	-0.3	-1.1	-0.3	0.8	-0.2	-0.3
Angina (self-reported)	1.4	1.9	4.7	-1.1	-1.3	-1.8	1.1	-1.1	1.2	1.3	-2.2	1.2	1.8	0.6	1.2
Migraine (self-reported)	0.2	0.2	0.6	-0.2	0.1	-0.2	-0.4	0.0	0.3	0.7	-0.5	0.7	0.6	0.5	0.5
Medication: Ibuprofen	0.2	0.2	0.7	0.5	0.1	0.0	-0.5	0.4	-0.2	-0.5	0.0	-0.7	0.2	-0.8	-0.6
Medication: Allopurinol	3.1	4.1	6.6	2.4	2.0	2.6	-2.2	1.6	-1.6	-1.9	2.4	-1.9	-2.1	-1.1	-2.0
Medication: Omeprazole	1.0	1.2	4.5	0.8	0.1	1.3	0.3	0.6	-0.0	-1.3	2.1	-1.2	-1.4	-0.9	-1.0
Medication: Seretide 50 evohaler	0.2	0.3	1.0	0.3	0.1	0.4	-0.2	-0.9	-0.2	-0.3	-0.7	-0.4	1.0	-0.4	-0.3
Mean time to correctly identify matches	0.1	0.3	0.6	0.3	0.4	-0.8	0.8	0.2	-0.5	-0.1	-0.5	0.1	-0.7	-0.8	-0.1
Heart disease (mother)	0.1	0.2	0.5	0.3	-0.1	0.5	-0.1	0.3	0.1	-0.6	0.5	-0.7	0.2	-0.5	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.6	4.3	7.7	1.9	2.2	2.5	-1.6	2.6	-1.7	-1.9	2.7	-1.7	-2.8	-0.8	-1.6
Whole body fat mass	1.1	4.4	8.0	2.4	2.7	2.2	-1.4	-0.2	-2.1	-2.8	0.1	-2.4	-1.7	-2.4	-2.5
Leg fat mass (right)	1.0	3.8	6.4	2.2	2.5	2.2	-1.6	-0.1	-1.9	-2.5	0.2	-2.2	-1.4	-2.2	-2.3
Arm predicted mass (right)	0.2	0.9	1.8	1.0	1.0	0.9	-0.9	-0.7	-0.9	-1.0	-0.1	-1.1	-0.4	-1.3	-1.1
Pulse rate, automated reading	1.4	4.6	9.8	1.9	3.1	2.6	-2.1	0.3	-1.9	-2.5	1.6	-2.4	-1.5	-2.0	-2.4
Alcohol intake frequency.	0.4	0.9	2.1	0.8	1.2	0.7	-1.1	1.3	-1.3	-0.4	0.6	-0.3	-1.4	-0.7	-0.6
Comparative height size at age 10	0.0	0.1	0.4	-0.3	0.6	0.0	-0.4	-0.4	0.5	0.1	0.5	-0.2	0.3	0.4	-0.1
Number of full sisters	1.2	1.5	4.4	0.5	0.8	1.1	-1.2	2.1	-0.6	-0.9	2.0	-0.8	-1.9	-0.4	-0.8
Suffer from ‘nerves’	3.5	5.6	10.0	-2.7	-2.2	-1.9	1.8	0.9	2.9	2.7	-1.2	2.7	2.1	3.2	2.8
Overall health rating	0.4	0.8	2.4	0.2	0.7	1.6	-0.6	1.5	0.1	-1.0	0.9	-0.9	-0.7	0.1	-0.7
Chest pain or discomfort	0.1	0.2	0.8	-0.1	-0.7	-0.4	0.1	-0.9	0.5	-0.3	-0.3	-0.5	0.5	-0.1	-0.2
Had major operations	0.3	0.3	0.8	0.7	-0.2	0.3	-0.1	0.9	-0.1	-0.6	0.9	-0.6	-0.5	-0.4	-0.5
Age at last live birth	1.5	2.2	3.5	-1.9	-1.5	-1.4	1.8	0.5	1.6	1.6	-0.4	1.7	0.6	1.8	1.8
Family relationship satisfaction	1.6	2.0	4.4	-1.4	-1.5	-1.1	1.5	0.3	1.5	1.4	-0.8	1.5	1.4	2.1	1.8
Leg pain on walking	0.5	0.7	1.7	0.7	0.6	0.4	0.2	-0.5	-0.8	-1.3	0.3	-0.9	-1.2	-1.0	-0.9
Qualifications: NVQ or HND or HNC or equivalent	4.6	5.6	9.1	2.9	2.7	1.9	-2.7	-0.1	-2.5	-2.5	1.3	-2.6	-1.4	-3.0	-2.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.4	-1.0	-0.6	-0.3	0.4	0.4	0.6	0.6	-0.3	0.7	0.2	1.2	0.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.4	0.9	0.5	0.2	-0.2	-0.3	-1.2	-1.2	0.0	-1.0	-1.0	-1.5	-1.1
Medication: Aspirin	0.4	0.6	2.2	-0.3	-0.7	-0.8	0.0	-1.4	0.2	0.2	-1.5	0.1	1.1	-0.1	0.1
Supplements: Vitamin C	1.2	1.4	4.2	-0.6	-2.1	-1.1	2.0	-1.0	0.6	0.6	-1.0	0.8	1.4	0.9	1.1
Knee pain experienced in last month	0.2	0.4	1.1	0.6	0.5	0.9	0.1	1.1	-0.1	-0.7	0.4	-0.4	-0.8	-0.4	-0.4
Hypertension (Self-reported)	0.2	0.5	1.4	0.5	1.2	1.1	0.2	0.0	0.5	-1.1	0.5	-0.8	-0.5	-0.5	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	3.0	4.6	-1.9	-1.5	-2.1	1.0	-0.8	1.5	2.0	-1.9	1.8	2.2	1.6	1.8
Illnesses of father: Heart disease	5.8	8.0	15.7	-3.0	-2.8	-2.8	1.8	-2.5	3.0	2.9	-3.5	2.5	4.0	2.1	2.6
Illnesses of siblings: Diabetes	8.5	10.4	14.4	3.4	3.1	3.0	-3.1	0.9	-3.5	-3.8	2.7	-3.6	-3.1	-3.8	-3.8
Smoking status: Previous	0.3	0.4	1.6	0.9	0.2	0.1	-0.5	-1.3	-0.6	-0.6	-0.3	-0.6	-0.3	-0.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.5	-0.1	-0.1	0.2	-0.7	0.5	-0.2	0.4	0.5	0.2	-0.1	0.6	0.2
Whole body fat-free mass	0.0	0.2	0.5	0.4	0.7	0.2	-0.5	-0.4	-0.4	-0.3	-0.4	-0.3	-0.2	-0.7	-0.5
Leg fat-free mass (right)	0.1	0.4	0.9	0.6	0.9	0.1	-0.8	-0.4	-0.9	-0.4	-0.6	-0.4	-0.5	-0.8	-0.6
Arm fat percentage (left)	0.7	2.7	4.8	1.9	2.2	1.9	-1.0	0.3	-1.5	-2.2	0.2	-1.7	-1.5	-1.8	-1.9
Average weekly red wine intake	0.1	0.2	0.5	0.1	-0.3	0.4	0.7	0.3	0.5	-0.6	0.3	-0.3	0.1	-0.2	-0.2
Handedness (chirality/laterality): Left-handed	3.4	4.1	6.8	-2.3	-1.1	-2.3	1.5	0.8	1.5	2.6	-1.9	2.5	2.0	2.4	2.4
Mood swings	0.5	1.0	2.1	-0.7	-1.1	-0.8	1.1	-0.4	1.0	0.8	-1.1	0.9	1.5	1.1	1.1
Loneliness, isolation	1.0	1.4	3.5	-1.4	-1.3	-0.6	0.7	1.3	1.6	1.4	0.2	1.2	0.0	1.9	1.3
Long-standing illness, disability or infirmity	0.9	1.4	2.4	-1.4	-1.0	-1.1	0.8	-0.5	1.4	1.4	-1.1	1.1	1.1	1.6	1.1
Ever had bowel cancer screening	0.9	1.1	4.8	-0.5	-0.1	-1.1	-0.1	-2.2	0.1	0.5	-2.0	0.2	1.6	-0.2	0.1
Diabetes diagnosed by doctor	4.8	7.8	11.8	3.1	3.4	2.9	-3.4	0.6	-3.0	-2.9	1.4	-3.0	-2.5	-2.8	-3.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.7	0.0	0.0	1.0	-0.2	0.6	0.5	-0.3	1.3	-0.3	-0.9	0.7	-0.2
Friendships satisfaction	3.2	4.0	6.7	-2.3	-1.5	-2.3	1.3	0.4	1.7	2.6	-1.7	2.3	2.3	2.1	2.4
Qualifications: nursing, teaching	1.2	1.9	3.3	-1.1	-1.1	-1.7	1.8	-1.8	1.2	1.0	-1.4	1.1	1.8	0.7	1.1
Commuting to job workplace: Walk	2.1	2.3	3.7	1.5	1.9	1.5	-1.9	0.3	-1.8	-1.7	1.3	-1.7	-1.0	-1.1	-1.7
Eye problems/disorders: Cataract	0.5	0.6	2.3	-0.3	0.3	-0.9	-0.4	-1.1	-0.1	0.8	-1.5	0.6	0.9	0.4	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	-0.3	0.4	-0.6	-0.6	-0.1	0.1	0.6	-0.3	0.4	0.5	0.2	0.2
Medication for cholesterol	0.7	1.1	1.9	-1.1	-1.4	-0.8	1.1	0.1	1.1	1.0	-0.9	1.0	1.3	1.1	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.7	-0.1	-0.3	0.8	-0.3	1.3	0.4	-0.1	0.9	-0.0	-0.6	0.5	0.1
Back pain experienced in last month	1.1	1.6	2.7	-1.1	-1.3	-1.0	1.3	0.1	1.6	1.2	-1.5	1.3	1.4	1.2	1.4
Mineral and other dietary supplements	0.6	0.9	2.6	0.6	0.5	-0.3	-1.1	-1.6	-1.4	-0.0	-1.5	-0.2	1.2	-0.4	-0.2
Breast cancer (self-reported)	0.9	1.0	3.8	-0.2	-0.9	-0.9	1.1	-1.9	0.4	0.3	-2.0	0.6	1.2	-0.0	0.6
Asthma (self-reported)	2.3	4.5	6.0	-2.2	-2.4	-2.2	1.6	-0.4	2.1	2.3	-2.5	2.3	2.2	2.2	2.3
Osteoporosis (self-reported)	0.1	0.2	0.9	-0.3	-0.4	-0.6	0.9	0.0	-0.2	0.1	-0.2	0.3	-0.3	0.2	0.2
Osteoarthritis (self-reported)	1.0	1.2	2.1	1.4	1.0	1.1	-0.3	1.2	-0.8	-1.2	1.1	-0.9	-1.5	-1.3	-1.1
Medication: Aspirin	0.2	0.3	0.7	0.4	0.0	0.1	-0.6	-0.9	-0.3	-0.6	-0.6	-0.7	0.3	-0.7	-0.6
Medication: Gliclazide	4.1	4.7	11.4	2.2	2.2	2.6	-3.4	1.9	-2.2	-1.6	2.3	-1.9	-2.0	-0.9	-1.9
Illnesses of father: None of the above (group 1)	0.4	0.5	2.7	0.6	0.1	-0.7	-0.5	-1.2	-1.6	-0.1	-0.5	-0.3	-0.2	-0.8	-0.5
Smoking status: Current	5.4	8.6	12.9	3.6	2.8	3.1	-2.0	1.1	-3.1	-3.6	2.1	-3.3	-3.0	-3.3	-3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.9	1.3	1.0	0.7	-0.9	-0.0	-1.2	-0.8	1.0	-1.0	-0.4	-1.7	-1.2
Whole body water mass	0.0	0.2	0.5	0.4	0.7	0.3	-0.6	-0.3	-0.4	-0.3	-0.3	-0.4	-0.2	-0.7	-0.5
Leg predicted mass (right)	0.1	0.4	0.9	0.6	1.0	0.1	-0.8	-0.4	-1.0	-0.4	-0.6	-0.4	-0.5	-0.9	-0.6
Arm fat mass (left)	0.7	2.7	5.2	1.9	2.3	1.9	-1.2	0.0	-1.6	-2.1	-0.0	-1.8	-1.3	-1.9	-1.9
Number of self-reported non-cancer illnesses	0.1	0.1	0.6	-0.2	-0.1	-0.1	0.4	0.8	0.6	0.2	-0.2	0.3	0.2	0.4	0.3
Average weekly champagne plus white wine intake	1.2	1.7	2.5	-1.4	-1.6	-1.5	1.5	-1.3	1.4	1.2	-1.0	1.2	1.3	0.9	1.3
Miserableness	1.0	1.8	3.1	-1.4	-1.4	-0.9	1.6	0.6	1.6	1.4	-0.3	1.4	1.3	1.8	1.6
Guilty feelings	0.8	1.2	4.8	-1.0	-0.7	0.2	1.0	1.2	2.2	0.6	1.3	0.6	-0.1	1.5	0.9
Wears glasses or contact lenses	7.1	8.2	11.4	-3.1	-2.9	-3.2	2.2	-1.0	2.3	3.4	-3.1	3.1	3.0	3.0	3.2
Ever taken oral contraceptive pill	0.4	0.5	1.7	0.7	0.3	0.2	-0.7	-1.3	-0.7	-0.3	-1.1	-0.6	0.2	-0.5	-0.5
Hearing aid user	1.2	1.4	3.2	-1.0	-1.8	-1.5	1.1	-1.4	0.3	1.0	-1.4	0.9	1.0	0.8	1.0
Mother’s age at death	1.9	2.3	5.8	-0.9	-1.1	-1.6	1.7	-2.4	0.5	1.1	-2.4	1.2	2.0	0.6	1.2
Financial situation satisfaction	0.4	0.5	1.8	0.2	1.3	1.1	-0.8	1.3	0.2	0.1	0.8	0.1	-0.5	0.7	-0.0
Tinnitus: Yes, now most or all of the time	4.8	5.6	9.7	-2.4	-2.7	-3.1	2.1	-0.5	1.9	2.8	-2.1	2.6	2.6	1.9	2.6
Commuting to job workplace: Public transport	0.4	0.4	0.9	-0.4	-0.7	-0.5	1.0	-0.3	0.5	0.6	-0.7	0.7	0.8	0.7	0.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.9	-0.5	-0.0	-1.0	-0.7	0.1	-0.6	1.0	0.1	0.6	-0.5	0.2	0.3
Medication: Blood pressure	0.8	1.6	2.7	1.4	1.3	1.1	-0.5	-0.6	-1.4	-1.7	0.6	-1.5	-1.2	-1.6	-1.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.9	0.4	1.4	0.4	0.5	0.4	-0.2	-0.9	-0.3	-0.3	-0.7	-0.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.0	-0.2	-0.4	0.5	0.9	1.5	1.1	-0.2	1.7	-0.0	-1.4	0.1	0.0
High cholesterol (Self-reported)	0.2	0.3	1.3	0.3	1.1	-0.1	-0.1	-0.7	-0.2	-0.1	-1.1	-0.0	0.6	-0.4	-0.2
Medication: Bendroflumethiazide	1.2	1.8	2.7	1.6	1.3	1.4	-0.7	-0.5	-1.3	-1.5	1.3	-1.5	-1.3	-1.6	-1.5
Medication: Paracetamol	1.1	1.7	3.0	1.3	1.2	1.5	-0.7	1.2	-0.7	-1.7	0.9	-1.5	-1.7	-1.2	-1.4
Medication: Lisinopril	1.0	1.2	2.5	1.1	0.8	0.9	-1.1	-1.6	-1.1	-1.3	-0.2	-1.4	-0.0	-1.2	-1.4
Medication: Atorvastatin	0.3	0.4	1.6	-0.4	0.0	-0.4	0.8	-0.9	0.7	0.0	-1.3	0.2	0.9	-0.1	0.2
Illnesses of father: High blood pressure	0.3	0.4	1.7	-0.3	0.3	0.6	-0.7	1.3	0.7	0.1	1.2	-0.2	-0.4	0.5	-0.1
Alcohol drinker status: Never	2.4	2.9	7.0	2.1	1.8	1.4	-1.8	0.4	-2.6	-1.6	1.1	-1.5	-1.8	-1.7	-1.6
Ever smoked	1.4	2.5	5.2	2.1	1.5	0.9	-0.5	-1.7	-1.8	-2.1	-0.3	-1.7	-0.8	-2.3	-1.8
Basal metabolic rate	0.1	0.7	1.3	0.9	1.1	0.8	-0.9	-0.2	-0.8	-0.9	-0.1	-0.9	-0.6	-1.1	-1.0
Leg fat percentage (left)	1.7	6.1	11.5	2.8	2.9	3.0	-1.9	-0.2	-2.1	-3.4	0.9	-3.0	-1.9	-2.6	-3.0
Arm fat-free mass (left)	0.2	0.8	1.6	1.0	1.3	0.8	-0.9	-0.5	-1.0	-1.0	-0.4	-1.0	-0.3	-1.2	-1.0
Number of operations (self-reported)	0.2	0.3	0.8	-0.2	-0.3	-0.5	0.9	0.9	0.2	0.3	-0.2	0.6	0.1	0.6	0.6
Average weekly beer plus cider intake	1.2	1.8	5.0	0.9	0.8	0.8	-1.6	1.6	-1.2	-1.1	1.7	-1.2	-2.2	-1.0	-1.3
Irritability	0.4	0.8	1.2	-0.7	-0.6	-0.6	1.1	0.5	0.9	0.7	-1.0	0.9	1.0	1.0	1.0
Risk taking	0.8	1.2	7.0	0.7	-0.7	-0.3	0.9	-2.6	-0.3	-0.8	-1.2	-0.7	0.4	-1.4	-0.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	-0.9	-0.9	-0.9	0.7	0.3	0.8	1.2	-0.0	1.0	0.4	1.2	1.0
Fractured/broken bones in last 5 years	1.7	2.2	3.1	-1.7	-1.0	-1.4	1.6	-1.0	1.7	1.5	-1.1	1.7	1.5	1.4	1.8
Age started oral contraceptive pill	1.5	1.9	7.4	-0.6	-0.2	-1.5	0.9	-2.5	-0.6	0.5	-2.7	0.6	2.1	-0.0	0.6
Diastolic blood pressure, automated reading	0.1	0.3	0.8	-0.3	-0.8	0.7	0.1	-0.9	0.9	-0.3	0.5	-0.4	0.5	0.2	-0.1
Ever depressed for a whole week	0.7	0.8	1.7	-1.0	0.3	-0.6	0.4	0.8	0.7	1.2	-0.6	1.3	0.9	1.2	1.2
Unable to work because of sickness or disability	0.5	0.6	2.6	0.7	1.1	0.3	-1.6	0.1	-1.2	-0.2	0.3	-0.5	-0.7	-0.5	-0.7
Commuting to job workplace: Cycle	0.4	0.5	1.7	-0.7	-1.3	-0.7	0.3	-0.2	1.0	1.0	-0.2	0.6	0.6	0.4	0.6
Myopia	0.3	0.4	1.4	0.4	0.2	0.5	-0.3	1.2	-0.2	-0.4	1.1	-0.4	-0.9	0.1	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.2	-0.9	-0.8	-0.1	0.5	-0.8	0.8	-0.1	0.6	-0.1	0.3	0.6
Cholesterol lowering medication	0.4	0.6	1.2	1.1	1.1	0.6	-0.4	-0.2	-1.0	-1.0	-0.1	-0.9	-0.3	-1.1	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.9	0.4	-0.1	1.0	0.5	0.1	0.2	-1.0	1.4	-0.9	-0.8	-0.5	-0.7
Pain experienced in last month	0.7	1.2	2.9	1.1	0.6	0.7	-1.7	-0.5	-1.3	-0.9	1.4	-1.2	-1.1	-1.0	-1.2
Supplements: Calcium	0.2	0.2	1.2	-0.1	-0.6	-0.6	1.1	0.2	-0.3	-0.1	0.1	0.2	-0.4	0.1	0.2
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	-0.5	-0.1	-0.4	-0.2	-0.4	0.1	0.8	-0.7	0.6	1.0	0.8	0.6
Heart attack/myocardial infarction (self-reported)	2.3	3.0	6.9	-2.0	-2.0	-1.0	1.4	0.6	2.6	1.5	-0.7	1.5	1.8	2.4	1.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.3	1.1	0.8	0.6	0.2	-0.1	-0.6	-1.0	1.0	-0.9	-0.9	-1.0	-0.8
Heart disease (siblings)	0.9	1.1	2.5	-1.2	-1.5	-1.2	0.6	0.4	0.8	1.6	-0.2	1.4	0.1	1.1	1.2
Alcohol drinker status: Previous	1.2	1.4	2.7	0.7	1.4	1.6	-1.6	1.2	-0.7	-1.2	1.1	-1.2	-1.1	-0.5	-1.1
Pack years of smoking	0.1	0.2	0.5	-0.4	0.6	-0.1	0.0	0.7	0.1	0.2	-0.7	0.4	0.3	0.6	0.4
Impedance of whole body	0.0	0.1	0.4	0.2	-0.1	0.0	-0.1	-0.0	-0.3	-0.4	0.6	-0.5	-0.1	0.1	-0.3
Leg fat mass (left)	1.2	4.6	7.4	2.5	2.7	2.4	-1.9	-0.1	-2.1	-2.7	0.3	-2.4	-1.6	-2.4	-2.6
Arm predicted mass (left)	0.2	0.8	1.4	1.0	1.1	0.8	-0.8	-0.6	-0.9	-1.0	-0.3	-1.0	-0.2	-1.2	-1.0