Hub : Genes

DNAH7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1140 0.0280 1.5e-14 0.126 0.107 0.125 0.106 0.130 4.2e-15 5.4e-13 6.4e-15 7.6e-13 1.4e-15
2 NTR Blood 0.0237 0.0082 3.3e-06 0.018 0.008 0.004 0.009 0.010 1.0e-06 8.8e-04 1.6e-02 6.1e-04 3.1e-04
3 ROSMAP Brain Pre-frontal Cortex 0.1805 0.0385 0.0e+00 0.167 0.200 0.225 0.225 0.212 7.0e-21 4.0e-25 1.7e-28 1.8e-28 1.1e-26
4 TCGA Breast Invasive Carcinoma 0.0357 0.0168 2.3e-06 0.014 0.023 0.022 NA 0.018 4.7e-04 1.4e-05 1.8e-05 NA 1.2e-04
5 TCGA Glioblastoma Multiforme 0.1580 0.0870 2.9e-03 0.023 0.077 0.084 NA 0.016 6.5e-02 2.5e-03 1.6e-03 NA 1.1e-01
6 TCGA Head and Neck Squamous Cell Carcinoma 0.0436 0.0224 9.0e-06 0.052 0.050 0.060 NA 0.063 1.5e-06 2.7e-06 2.7e-07 NA 1.4e-07
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0754 0.0367 1.8e-04 0.035 0.026 0.020 NA 0.027 6.7e-05 5.8e-04 2.5e-03 NA 4.5e-04
8 TCGA Brain Lower Grade Glioma 0.0472 0.0257 1.6e-04 0.006 0.033 0.033 NA 0.021 5.5e-02 1.0e-04 1.1e-04 NA 1.6e-03
9 TCGA Lung Squamous Cell Carcinoma 0.0342 0.0178 1.4e-04 0.046 0.031 0.030 NA 0.034 5.3e-06 1.8e-04 1.9e-04 NA 8.2e-05
10 TCGA Pancreatic Adenocarcinoma 0.0770 0.0530 6.2e-03 0.046 0.047 0.024 NA 0.052 5.1e-03 4.9e-03 3.3e-02 NA 3.2e-03
11 TCGA Prostate Adenocarcinoma 0.1540 0.0594 2.7e-14 0.113 0.146 0.152 NA 0.149 6.8e-12 4.7e-15 1.3e-15 NA 2.7e-15
12 TCGA Thyroid Carcinoma 0.1510 0.0550 7.7e-14 0.167 0.140 0.102 NA 0.145 4.9e-16 1.5e-13 3.6e-10 NA 5.2e-14

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 1.1 1.7 4.4 -0.7 -2.1 -1.4 1.4 -1.5 0.4 0.7 -1.9 1.1 1.6 0.6 1.0
Bipolar Disorder or Schizophrenia 2.7 6.6 16.2 -1.8 -2.4 -3.0 2.5 -2.5 1.1 2.3 -4.0 2.6 3.3 1.6 2.4
Depressed Affect (Nagel 2018) 0.8 1.6 4.6 -1.2 -1.2 -0.5 0.8 2.1 1.6 1.2 0.5 1.2 0.3 1.8 1.3
Depression (Nagel 2018) 0.9 1.4 6.7 -0.9 -1.0 -0.4 0.4 2.6 1.3 1.2 0.6 1.0 -0.2 1.4 1.0
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.4 -0.5 -1.1 -0.5 -0.6 0.4 0.5 1.2 -0.0 0.8 0.6 0.8 0.8
Neuroticism (Nagel 2018) 1.9 4.4 8.5 -2.4 -2.0 -1.7 1.3 2.1 2.7 2.3 -0.1 2.2 1.5 2.9 2.4
Schizophrenia (2018) 2.5 5.3 13.6 -1.7 -1.4 -2.8 2.1 -2.0 1.0 2.3 -3.7 2.5 2.9 1.5 2.3
Schizophrenia vs Biploar Disorder 0.2 0.3 1.4 -0.3 1.2 -0.6 -0.2 -0.4 -0.6 0.3 -1.0 0.3 0.1 -0.3 -0.0
Worry (Nagel 2018) 4.6 9.7 13.0 -3.5 -3.1 -3.2 2.8 0.4 3.5 3.3 -2.3 3.4 3.2 3.6 3.6
Alzheimer’s Disease (in mother) 1.2 1.4 5.5 1.1 0.6 -0.1 -0.3 -2.4 -1.4 -1.3 -0.5 -1.3 0.1 -1.8 -1.2
Alzheimer’s Disease (in father) 0.2 0.2 0.9 0.6 -0.3 0.1 0.5 -0.9 -0.1 -0.4 0.2 -0.3 -0.3 -0.7 -0.3
Alzheimer’s Disease (including proxy) 0.6 0.9 5.6 0.9 -0.1 -0.3 0.3 -2.4 -0.8 -0.8 -0.5 -0.6 0.3 -1.4 -0.5
Crohns Disease (2017) 0.7 1.6 3.1 -1.3 -1.8 -1.2 1.5 0.2 1.5 1.4 -0.1 1.4 0.9 1.2 1.4
Irritable Bowel Disease (IBD) 0.4 1.0 3.6 -0.9 -1.7 -1.0 1.9 -0.3 1.2 0.5 -0.2 0.8 0.6 0.3 0.7
Ulcerative Colitis (UC) 0.2 0.3 1.3 -0.1 -0.7 -0.5 1.1 -0.8 0.2 -0.5 -0.6 -0.1 0.2 -0.8 -0.2
Major Depression (MDD) 1.9 2.3 4.0 -1.3 -1.0 -1.5 1.4 -0.3 1.5 1.9 -1.6 2.0 1.5 1.5 1.9
Reaction Time 0.3 0.5 1.6 0.8 0.7 -0.3 0.1 0.7 -1.2 -0.3 0.2 -0.1 -1.3 -0.9 -0.4
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.7 -0.7 -1.1 -0.3 0.4 0.2 0.9 0.7 0.2 0.6 0.5 1.3 0.9
Breast Cancer 0.1 0.2 0.9 0.0 0.0 -0.7 -0.2 -0.9 -0.6 0.4 -0.5 -0.1 0.2 -0.1 -0.0
Ovarian Cancer 0.2 0.3 0.7 -0.3 0.1 0.7 -0.2 0.5 0.7 0.4 0.9 0.2 -0.6 0.6 0.2
Prostate Cancer 0.7 0.9 3.7 -0.4 -0.4 -1.7 0.2 -1.9 -0.4 0.4 -1.7 0.4 0.7 -0.5 0.1
Age at First Birth 0.3 0.5 1.3 -0.7 -0.3 -1.2 1.1 -0.1 0.4 0.6 -0.4 0.6 -0.0 0.9 0.8
Bipolar Disorder (2011) 8.3 8.0 10.7 -2.9 -3.3 -3.1 2.9 -1.0 2.0 2.7 -3.2 3.0 3.3 2.7 3.0
Body Mass Index (BMI) (2010) 2.0 2.7 5.0 -2.0 -1.8 -0.9 1.5 0.8 2.2 1.7 -1.1 1.8 1.6 2.0 1.8
Coronary Artery Disease (CAD) 0.2 0.2 1.1 -0.8 -0.0 0.5 0.2 0.6 1.1 0.2 0.1 -0.1 -0.1 0.7 -0.1
Crohns Disease (2012) 1.5 2.4 3.7 -1.8 -1.8 -1.5 1.5 1.9 1.4 1.6 0.1 1.8 0.7 1.6 1.7
Mean Putamen Volume 0.1 0.1 0.6 0.4 0.4 0.8 -0.1 -0.4 -0.3 -0.2 0.3 -0.3 -0.3 -0.2 -0.1
Fasting Glucose 0.3 0.3 0.8 -0.6 -0.9 -0.3 0.8 0.4 0.8 0.5 0.8 0.2 -0.5 0.1 0.3
HbA1C 0.1 0.1 0.8 -0.1 0.9 -0.1 -0.2 0.5 0.2 0.1 -0.1 0.1 0.4 0.4 0.1
HDL Cholesterol 0.3 0.4 0.9 0.6 1.0 0.8 -0.7 0.2 -0.6 -0.6 0.8 -0.3 -0.9 -0.2 -0.5
LDL Cholesterol 0.3 0.4 0.9 0.3 0.6 0.3 -0.5 -0.7 -0.4 -0.8 -0.2 -0.9 -0.2 -1.0 -0.8
Lupus 1.0 1.5 3.9 -1.4 -1.6 -0.4 0.7 1.4 2.0 1.4 0.3 1.2 0.4 1.4 1.2
Neuroticism (2016) 2.1 3.0 5.4 -2.0 -1.3 -1.1 1.5 1.3 2.3 2.1 -0.3 1.9 1.4 2.3 2.2
Primary Biliary Cirrhosis 0.1 0.1 0.7 0.5 0.2 -0.0 -0.5 -0.1 -0.8 -0.1 -0.2 -0.1 -0.1 -0.3 -0.2
Rheumatoid Arthritis 0.3 0.4 2.2 -0.4 0.6 0.6 -0.7 1.5 0.8 0.3 0.6 0.2 -0.4 0.4 0.1
Schizophrenia (2014) 2.0 4.5 10.2 -1.9 -1.6 -2.6 2.1 -0.8 0.9 2.3 -3.2 2.5 2.3 1.6 2.2
Triglycerides 0.2 0.3 1.6 -0.6 -0.7 -0.2 0.5 0.2 1.2 0.5 -0.7 0.1 0.7 0.4 0.3
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.0 0.8 -0.0 1.2 -0.7 0.3 -0.8 -1.4 1.1 -1.4 -0.7 -1.3 -1.3
Ulcerative Colitis 0.6 0.9 3.0 -0.9 -1.7 -1.4 1.4 0.0 0.6 0.5 -0.5 0.9 0.3 0.5 0.8
Blood Eosinophil Count 2.7 20.6 36.5 -4.5 -4.0 -4.2 6.0 -0.9 4.5 4.1 -5.0 5.0 4.4 4.9 5.2
Blood Platelet Count 0.1 0.9 6.2 0.5 2.5 0.8 -1.1 -0.4 -0.5 -0.7 -0.3 -0.5 0.2 -0.3 -0.7
Blood Red Count 0.4 3.5 8.6 -1.7 -2.9 -2.1 1.5 -2.4 1.8 1.9 -1.4 1.3 2.3 0.9 1.4
Blood White Count 0.0 0.3 1.0 0.2 1.0 0.1 -0.7 -0.1 -0.1 -0.4 0.1 -0.6 -0.1 -0.8 -0.6
Heel T-Score 3.1 24.7 42.9 4.7 4.5 5.3 -5.2 3.3 -4.0 -4.5 6.3 -5.0 -6.5 -4.3 -5.2
BMI 0.4 2.2 3.9 1.7 1.5 2.0 -1.0 -0.1 -1.4 -1.9 -0.1 -1.6 -1.3 -1.8 -1.7
Height 0.1 1.9 3.8 1.2 1.2 -0.0 -1.9 -1.9 -1.6 -1.2 -0.2 -1.6 0.2 -2.0 -1.6
Waist Hip Ratio (WHR) 0.3 1.6 3.1 1.1 0.9 1.6 -1.7 -0.8 -0.8 -1.5 0.4 -1.8 -0.2 -1.2 -1.6
Systolic Blood Pressure 1.0 5.2 9.7 2.3 2.6 1.9 -3.1 -0.4 -2.3 -2.3 1.3 -2.8 -0.9 -2.8 -2.8
Smoking Status 2.5 6.0 10.8 3.3 2.1 2.0 -1.8 0.1 -3.0 -2.9 1.5 -2.7 -2.6 -2.8 -2.8
Allergy or Eczema 2.4 6.4 8.7 -3.0 -2.4 -2.5 2.3 -0.9 2.8 2.7 -2.4 2.6 2.8 2.7 2.7
Cardiovascular Disease 0.8 2.6 5.2 1.2 1.7 2.3 -1.2 1.6 -0.2 -1.6 2.2 -1.5 -2.2 -0.9 -1.5
Hypothyroidism (self reported) 0.3 0.6 2.3 -0.6 -0.9 -0.6 0.7 1.5 0.2 0.7 0.2 0.9 -0.1 0.8 0.9
Respiratory disease 0.7 1.5 2.8 -1.1 -1.5 -1.1 0.6 0.2 0.7 1.5 -1.4 1.5 0.9 1.7 1.5
Type 2 Diabetes (T2D) (2018) 4.9 9.1 15.8 3.4 3.4 2.7 -4.0 0.9 -3.4 -2.8 1.8 -3.1 -2.9 -3.2 -3.4
Lung FEV1/FVC ratio 0.3 1.4 2.8 1.4 1.2 1.0 -0.9 1.2 -1.0 -1.0 1.7 -1.1 -0.9 -1.5 -1.2
Lung FVC 0.2 0.9 2.3 1.1 0.5 1.0 -0.7 -0.6 -0.8 -0.9 0.9 -1.1 -0.7 -1.5 -1.2
Neuroticism 1.4 3.3 7.5 -2.0 -1.6 -1.4 1.7 1.2 2.7 1.8 -0.4 1.8 1.6 2.3 2.1
Chronotype (morning person) 0.5 1.2 6.2 -0.9 -0.9 -0.9 1.3 -2.5 0.6 0.4 -1.4 0.5 1.1 0.2 0.6
Hair Pigment 0.4 12.3 16.4 3.8 3.7 4.0 -3.3 0.8 -3.3 -3.9 3.3 -3.9 -3.3 -3.5 -4.0
Tanning 0.1 1.6 2.8 1.3 1.2 1.0 -1.7 -0.3 -1.6 -1.2 0.6 -1.3 -1.3 -1.4 -1.5
Hand grip strength (left) 0.7 1.8 4.7 1.2 0.8 0.6 -1.6 -2.2 -1.3 -1.2 -0.3 -1.6 0.6 -1.8 -1.6
Number of treatments/medications taken 0.5 0.9 2.9 -0.7 -0.4 -0.7 1.0 -0.8 1.1 0.6 -1.7 0.6 1.4 0.6 0.6
Average weekly spirits intake 1.2 1.5 5.4 1.1 2.3 1.3 -1.4 0.4 -1.1 -1.0 0.4 -1.0 -0.8 -1.2 -1.2
Sensitivity / hurt feelings 1.4 2.5 4.4 -1.7 -1.9 -1.9 1.1 -0.9 1.7 1.6 -1.7 1.3 2.1 1.0 1.4
Frequency of depressed mood in last 2 weeks 2.8 3.9 6.7 -2.3 -1.9 -1.7 1.2 2.0 2.3 2.6 -0.7 2.3 1.1 2.4 2.2
Hearing difficulty/problems: Yes 2.9 4.4 7.1 -1.9 -2.1 -2.4 0.9 -1.3 1.4 2.7 -2.6 2.2 2.6 2.1 2.2
Relative age of first facial hair 2.2 4.6 7.5 2.6 1.4 2.4 -1.3 0.8 -2.2 -2.7 1.9 -2.5 -2.2 -2.4 -2.4
Other serious medical condition/disability diagnosed by doctor 2.0 2.6 4.6 -1.9 -1.3 -1.2 1.1 1.4 1.7 2.0 -0.6 2.0 1.4 2.1 2.0
Ever used hormone-replacement therapy (HRT) 1.8 2.4 3.4 -1.4 -1.4 -1.6 1.0 -1.4 1.1 1.7 -1.8 1.6 1.9 1.7 1.7
Ever had hysterectomy (womb removed) 0.2 0.3 0.7 0.6 -0.1 0.7 -0.4 0.4 -0.3 -0.6 0.6 -0.5 -0.9 -0.2 -0.4
Systolic blood pressure, automated reading 2.1 6.0 9.6 2.6 3.1 2.0 -2.7 -1.5 -2.6 -2.7 0.7 -2.8 -0.9 -3.1 -3.0
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 1.8 1.1 1.2 0.8 -1.2 -1.4 -1.3 -1.2 -0.2 -1.3 -0.1 -0.9 -1.2
Angina 1.3 1.7 3.9 -1.0 -1.3 -1.6 1.0 -0.9 1.2 1.3 -2.0 1.1 1.8 0.8 1.2
Medication for hormone replacement therapy 0.1 0.2 0.5 -0.3 -0.2 -0.1 -0.6 -0.0 0.2 0.7 -0.1 0.4 0.3 0.7 0.3
Vitamin and mineral supplements 3.2 4.4 8.3 2.2 2.9 1.9 -2.6 -0.8 -2.4 -2.2 0.8 -2.2 -1.5 -2.3 -2.3
Supplements: Zinc 3.0 3.3 10.6 1.2 1.0 1.5 -1.2 3.0 -1.2 -1.0 3.3 -1.1 -2.8 -0.6 -1.2
Medication: Co-codamol 0.2 0.2 0.6 0.4 0.8 0.2 -0.5 -0.1 -0.7 -0.4 -0.5 -0.3 -0.2 -0.6 -0.5
Medication: Metformin 3.0 4.3 6.1 2.4 2.4 1.8 -2.4 0.6 -2.5 -2.1 0.8 -2.2 -2.0 -2.2 -2.3
Diabetes (father) 2.0 2.5 6.5 1.1 0.8 1.4 -1.3 2.5 -1.2 -1.5 2.1 -1.5 -2.0 -1.3 -1.3
Diabetes (mother) 1.7 2.2 7.2 1.2 1.6 1.2 -2.7 -0.0 -1.5 -0.8 1.3 -1.4 -1.8 -1.2 -1.6
Severe depression (siblings) 0.1 0.1 0.4 -0.2 0.3 0.4 0.1 0.5 0.2 -0.3 0.7 -0.3 -0.1 -0.2 -0.2
Pack years adult smoking proportion 0.1 0.2 0.6 -0.4 0.5 -0.1 0.0 0.8 0.1 0.2 -0.7 0.4 0.3 0.6 0.5
Impedance of leg (right) 0.1 0.3 1.2 0.3 0.1 0.7 -0.4 0.4 -0.0 -0.5 1.1 -0.7 -0.1 0.1 -0.4
Leg fat-free mass (left) 0.0 0.2 0.6 0.4 0.8 0.0 -0.5 -0.2 -0.7 -0.2 -0.6 -0.1 -0.3 -0.6 -0.3
Trunk fat percentage 0.9 3.6 6.9 2.2 2.4 1.7 -1.1 -0.6 -2.2 -2.6 -0.4 -2.1 -1.4 -2.2 -2.2
Hand grip strength (right) 1.0 2.8 4.5 1.6 1.3 1.6 -2.1 -1.7 -1.5 -1.8 0.9 -2.1 -0.4 -2.0 -2.1
Townsend deprivation index at recruitment 3.3 4.7 7.9 2.3 2.7 1.5 -2.8 0.3 -2.6 -2.0 1.2 -2.2 -1.7 -2.8 -2.4
Current tobacco smoking 6.4 10.5 15.3 3.9 3.3 3.4 -2.4 1.3 -3.6 -3.8 2.3 -3.5 -3.4 -3.5 -3.6
Average weekly fortified wine intake 0.3 0.4 1.3 -0.6 -0.7 -0.7 1.2 -0.3 0.3 0.4 -0.6 0.6 0.4 0.6 0.7
Maternal smoking around birth 6.0 8.6 12.2 3.5 2.7 3.0 -2.9 0.1 -3.0 -3.4 2.4 -3.4 -2.7 -3.1 -3.4
Fed-up feelings 0.3 0.5 2.4 0.2 0.5 0.5 -0.8 1.6 -0.2 0.2 1.2 0.0 -0.9 0.2 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.3 7.3 -0.6 -0.4 0.2 -0.0 2.7 1.3 1.1 1.2 0.8 -0.4 1.3 0.8
Relative age voice broke 0.9 1.3 2.3 1.3 0.5 0.8 -0.7 0.2 -1.4 -1.4 1.0 -1.5 -1.1 -1.5 -1.4
Taking other prescription medications 1.1 1.7 3.4 -1.5 -1.0 -0.9 1.0 1.0 1.5 1.4 -0.8 1.4 1.4 1.8 1.4
Age when periods started (menarche) 1.9 4.6 7.1 -2.3 -2.7 -2.6 2.1 -1.6 1.9 1.8 -2.7 1.8 2.5 1.4 1.9
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.2 -0.2 -0.6 -0.9 0.3 -0.8 -0.4 0.8 -1.0 0.6 1.1 0.6 0.6
Heel bone mineral density (BMD) T-score, automated (left) 2.3 5.3 10.5 1.9 2.4 2.9 -1.6 1.8 -0.9 -2.4 3.2 -2.3 -3.2 -1.7 -2.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 0.9 -0.7 -0.3 -0.6 0.9 -0.6 0.9 0.7 -0.4 0.6 1.0 0.7 0.7
Qualifications: CSEs or equivalent 0.4 0.5 1.2 -0.8 0.0 -0.3 0.1 -0.1 1.1 0.8 -0.5 0.8 0.9 1.1 0.7
Serious illness, injury or assault to yourself 2.4 2.9 5.3 -2.1 -2.1 -1.3 1.4 -0.3 2.3 1.8 -0.6 1.7 1.3 2.3 1.8
High blood pressure 0.4 1.0 2.9 0.8 1.7 1.6 -0.2 -0.0 0.2 -1.4 0.8 -1.1 -0.6 -0.8 -1.1
Hayfever, allergic rhinitis or eczema 2.3 5.1 7.6 -2.5 -1.9 -2.4 1.9 -0.8 2.3 2.4 -2.4 2.2 2.8 2.3 2.4
Multivitamins +/- minerals 2.5 3.2 4.4 -1.9 -2.0 -1.4 1.9 1.8 2.1 2.1 -0.2 2.1 0.4 2.0 2.1
Stomach or abdominal pain in last month 0.1 0.1 0.6 -0.0 0.8 0.4 -0.4 0.3 0.4 -0.1 0.6 -0.1 -0.2 0.4 -0.2
Supplements: Glucosamine 0.3 0.4 1.9 -0.2 0.0 0.3 0.8 1.4 0.8 -0.1 0.6 0.2 -0.8 0.3 0.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.3 -0.7 0.5 -0.3 0.1 -0.5 0.2 0.4 -1.1 0.3 1.0 0.4 0.3
Medication: Atenolol 0.3 0.4 1.3 -0.2 -0.5 -0.8 0.2 -1.1 0.2 0.5 -0.9 0.3 0.9 0.6 0.4
Medication: Levothyroxine sodium 0.3 0.4 1.3 -0.6 -0.1 -0.9 0.4 1.1 -0.1 0.8 -0.2 1.0 -0.0 0.5 0.8
Sitting height 0.5 3.9 6.2 -2.5 -2.4 -1.7 1.9 -0.2 2.5 2.0 -1.3 1.8 1.7 2.4 2.1
Chronic bronchitis/emphysema (father) 1.1 1.2 6.9 -0.7 0.4 0.8 -0.4 2.6 0.8 0.4 1.4 0.4 -1.3 1.4 0.4
High blood pressure (mother) 0.8 1.2 5.5 -0.8 -0.7 0.4 0.9 2.3 1.6 0.5 1.0 0.7 -0.7 1.1 0.6
Body mass index (BMI) 0.9 3.7 6.2 2.2 2.4 2.2 -1.4 0.0 -1.9 -2.5 0.2 -2.1 -1.7 -2.3 -2.3
Impedance of leg (left) 0.2 0.9 1.8 1.0 0.6 1.2 -0.9 0.0 -0.6 -1.2 1.2 -1.3 -0.6 -0.6 -1.1
Leg predicted mass (left) 0.0 0.2 0.7 0.4 0.8 0.0 -0.6 -0.2 -0.7 -0.2 -0.6 -0.2 -0.3 -0.6 -0.4
Trunk fat mass 0.8 3.2 6.0 2.1 2.3 1.7 -1.2 -0.4 -1.9 -2.5 -0.2 -2.0 -1.4 -2.1 -2.1
Waist circumference 1.1 3.9 6.8 2.2 2.2 2.1 -1.6 -0.8 -1.9 -2.6 0.2 -2.4 -1.4 -2.3 -2.4
Number of incorrect matches in round 0.8 1.4 3.2 -1.0 0.5 -1.6 0.9 -0.3 0.2 1.5 -1.8 1.7 1.2 0.9 1.4
Past tobacco smoking 1.2 2.1 4.2 -2.0 -1.4 -0.8 1.1 1.4 1.6 1.7 0.1 1.6 0.8 2.1 1.7
Alcohol usually taken with meals 3.9 6.4 9.8 -2.6 -2.5 -3.1 2.8 -1.5 1.9 2.6 -2.6 2.7 2.6 2.2 2.8
Nervous feelings 1.8 3.3 4.9 -1.9 -1.9 -1.8 1.6 0.1 2.1 2.0 -1.1 2.0 1.8 2.2 2.2
Frequency of tenseness / restlessness in last 2 weeks 3.7 5.7 8.6 -2.6 -2.4 -1.9 1.9 1.4 2.8 2.9 -1.1 2.9 2.0 2.9 2.9
Hearing difficulty/problems with background noise 1.4 2.2 4.0 -1.6 -2.0 -1.4 0.5 0.7 1.8 2.0 -0.2 1.6 1.1 1.9 1.6
Hair/balding pattern: Pattern 2 0.3 0.4 0.7 -0.6 -0.6 -0.5 0.7 0.5 0.5 0.6 -0.4 0.8 0.1 0.8 0.9
Had menopause 0.3 0.3 1.2 -0.2 -0.1 -0.8 -0.3 -1.0 -0.4 0.4 -1.1 0.3 0.6 -0.1 0.1
Had other major operations 0.4 0.5 1.2 -0.5 -0.4 -0.8 0.3 0.9 -0.1 1.0 -0.5 1.1 0.2 1.0 1.0
Forced vital capacity (FVC) 0.5 1.8 3.2 1.4 1.0 1.3 -1.8 -1.2 -1.2 -1.3 1.0 -1.8 -0.3 -1.3 -1.7
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.6 7.2 1.2 2.1 2.3 -1.9 2.3 -0.6 -1.5 2.7 -1.6 -2.7 -1.0 -1.6
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 2.4 -1.3 -0.5 -0.9 1.1 0.8 1.3 1.1 -0.8 1.2 1.1 1.5 1.4
Qualifications: None of the above 0.0 0.1 0.2 -0.1 -0.2 0.5 0.3 0.3 0.3 -0.1 0.2 -0.0 -0.2 0.4 0.1
Financial difficulties in last 2 years 1.0 1.4 4.5 0.5 1.0 1.7 -0.5 2.1 0.2 -0.6 2.0 -0.5 -1.7 -0.1 -0.6
Mouth/teeth dental problems 0.3 0.5 1.2 -0.5 -0.5 -0.9 0.7 -1.1 -0.2 0.6 -1.1 0.5 0.8 0.7 0.6
Heart attack 2.3 2.9 7.0 -2.0 -2.0 -0.9 1.4 0.6 2.6 1.5 -0.6 1.5 1.8 2.4 1.8
Allergy 1.8 4.2 6.1 2.1 1.9 2.2 -2.0 1.2 -2.2 -2.0 2.2 -2.0 -2.5 -2.1 -2.2
Pain all over the body in last month 1.2 1.3 4.4 0.7 1.2 -0.2 -1.5 -1.2 -2.1 -0.9 -0.8 -1.1 0.1 -1.3 -1.2
Diabetes (self-reported) 3.5 5.4 8.7 2.6 2.7 2.4 -3.0 0.9 -2.6 -2.3 1.4 -2.4 -2.3 -2.0 -2.5
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.5 0.1 0.2 -0.2 0.0 0.2 -0.7 -0.2 -0.5 -0.0 -0.1 -0.3 -0.1
Medication: Ramipril 2.0 2.5 4.9 1.6 1.9 1.5 -2.2 -0.2 -1.6 -1.7 0.7 -1.9 -1.2 -1.7 -1.9
Medication: Simvastatin 1.1 1.7 3.1 1.6 1.4 0.6 -1.4 -1.5 -1.5 -1.2 -0.5 -1.4 0.0 -1.8 -1.4
Fluid intelligence score 0.5 1.1 3.3 -1.1 -1.8 -0.8 0.2 0.3 1.0 1.4 0.0 1.1 0.7 1.3 1.2
Illnesses of siblings 0.2 0.2 0.7 0.7 -0.1 -0.2 -0.5 -0.7 -0.8 0.1 -0.6 -0.1 0.7 -0.2 -0.1
Neuroticism score 1.2 2.6 5.4 -1.7 -1.7 -1.2 1.7 0.6 2.3 1.5 -0.6 1.4 1.8 2.0 1.8
Weight 0.8 3.8 5.8 2.2 2.3 2.0 -1.7 -0.3 -2.0 -2.4 0.4 -2.2 -1.5 -2.3 -2.3
Impedance of arm (right) 0.2 1.0 2.1 -1.0 -1.0 -1.4 0.7 0.6 0.6 1.2 -0.2 1.1 0.4 1.4 1.2
Arm fat percentage (right) 0.5 1.8 3.7 1.6 1.9 1.6 -0.7 0.4 -1.2 -1.8 -0.1 -1.3 -1.2 -1.4 -1.5
Trunk fat-free mass 0.0 0.1 0.3 0.2 0.4 0.4 -0.5 -0.1 -0.1 -0.2 0.0 -0.3 -0.1 -0.5 -0.4
Hip circumference 0.5 2.1 3.2 1.8 1.7 1.4 -1.1 -0.1 -1.5 -1.8 0.3 -1.6 -1.4 -1.7 -1.7
Time employed in main current job 0.9 1.0 2.8 1.1 0.0 -0.1 0.4 -1.2 -0.9 -1.5 -0.2 -1.3 0.1 -1.7 -1.2
Alcohol intake versus 10 years previously 1.4 2.1 6.0 1.5 1.0 1.4 -1.0 1.2 -1.9 -1.4 1.3 -1.1 -2.4 -1.4 -1.3
Father’s age at death 1.0 1.3 3.1 -1.5 -1.4 -0.2 1.0 1.0 1.8 1.1 -0.1 1.1 0.4 1.7 1.3
Worrier / anxious feelings 3.5 6.7 9.5 -3.1 -2.4 -2.5 2.4 0.3 3.1 2.9 -2.0 2.8 2.3 3.0 3.0
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 7.3 -0.6 0.3 0.1 -0.1 2.7 0.9 0.6 1.0 0.5 -0.5 0.9 0.5
Falls in the last year 0.2 0.2 1.4 0.3 -0.1 0.4 -0.0 -0.4 -0.1 -0.2 0.9 -0.2 -1.2 -0.5 -0.3
Hair/balding pattern: Pattern 3 1.4 2.1 5.4 1.0 1.0 1.5 -0.7 1.6 -0.6 -1.4 2.3 -1.2 -2.2 -1.1 -1.3
Number of live births 1.0 1.4 2.6 1.4 1.6 1.3 -1.1 -0.0 -0.9 -1.3 0.8 -1.2 -1.2 -1.4 -1.3
Forced expiratory volume in 1-second (FEV1) 0.6 2.2 3.5 1.7 1.3 1.3 -1.8 -0.8 -1.6 -1.5 1.2 -1.9 -0.4 -1.7 -1.8
Pulse rate 0.5 0.8 2.0 0.9 1.0 1.2 0.2 -1.4 -0.6 -1.3 -0.1 -0.9 0.1 -0.7 -0.7
Happiness 2.6 3.1 5.5 -2.1 -0.9 -1.8 1.0 0.8 1.6 2.3 -1.3 2.2 1.7 2.3 2.1
Noisy workplace 0.9 1.1 6.7 1.0 0.3 -0.1 0.0 -2.6 -0.4 -0.9 -0.9 -1.0 0.9 -1.1 -0.9
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.5 1.0 1.2 0.5 -1.1 -0.7 -1.1 -0.5 0.5 -0.6 -0.7 -0.6 -0.6
Serious illness, injury or assault of a close relative in last 2 years 4.3 4.9 9.7 -2.6 -2.0 -1.5 1.6 0.5 2.7 2.3 -1.5 2.2 2.7 3.1 2.5
Mouth/teeth dental problems: Dentures 1.1 1.8 3.0 1.7 1.4 1.5 -0.7 0.4 -1.3 -1.6 1.0 -1.3 -1.7 -1.6 -1.4
Asthma 1.7 3.3 4.6 -1.8 -2.1 -1.9 1.4 -0.6 1.9 1.9 -2.1 1.8 1.9 2.0 1.9
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.8 0.2 -0.0 0.2 -0.6 0.9 0.2 -0.2 0.5 -0.5 0.1 -0.3 -0.4
Medication: Cholesterol lowering 1.1 1.8 7.7 -0.8 -0.2 -1.3 0.6 -1.8 0.8 1.0 -2.8 0.9 2.1 0.4 0.7
Depression (self-reported) 2.1 2.5 4.7 -1.8 -1.7 -1.5 1.0 1.2 2.2 2.0 -0.6 1.7 1.3 1.5 1.6
Medication: Lansoprazole 0.5 0.5 1.7 -0.8 -0.3 -1.0 0.2 -0.2 0.4 0.8 -1.3 0.7 0.7 0.8 0.6
Prospective memory result 0.1 0.1 0.4 -0.3 0.6 -0.5 -0.4 -0.6 -0.1 0.2 -0.1 -0.0 -0.1 0.1 -0.1
Lung cancer (father) 0.2 0.2 0.8 -0.3 -0.4 -0.6 -0.9 0.2 -0.3 0.7 -0.3 0.3 0.4 0.3 0.2
Illnesses of mother 0.1 0.1 0.5 0.0 -0.1 -0.4 0.1 -0.7 -0.3 0.3 -0.4 0.3 0.3 -0.1 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 2.1 1.2 0.8 0.7 -1.4 -0.4 -1.3 -0.8 0.8 -1.2 -0.1 -1.4 -1.3
Pulse wave Arterial Stiffness index 0.3 0.4 0.8 -0.3 -0.8 -0.7 0.8 0.1 0.3 0.5 -0.8 0.7 0.6 0.9 0.7
Impedance of arm (left) 0.0 0.2 0.6 -0.4 -0.6 -0.8 0.3 0.3 0.1 0.5 0.4 0.4 0.0 0.7 0.5
Arm fat mass (right) 0.7 2.9 5.3 1.9 2.3 1.9 -1.3 0.1 -1.7 -2.2 -0.0 -1.8 -1.4 -1.9 -2.0
Trunk predicted mass 0.0 0.1 0.3 0.3 0.5 0.4 -0.6 -0.1 -0.1 -0.2 0.1 -0.4 -0.2 -0.6 -0.4
Standing height 0.0 0.2 0.8 0.1 0.0 -0.3 -0.8 -0.9 -0.3 -0.1 0.2 -0.5 0.4 -0.3 -0.4
Length of working week for main job 0.2 0.2 1.0 -0.2 0.4 -0.6 -1.0 0.3 -0.3 0.7 -0.2 0.4 0.2 0.2 0.2
Exposure to tobacco smoke at home 0.8 0.9 2.1 0.8 1.0 1.3 -0.4 1.3 -0.6 -1.0 1.1 -0.8 -1.4 -0.4 -0.7
Breastfed as a baby 0.3 0.3 1.0 0.6 0.2 0.7 -1.0 0.4 -0.1 -0.3 1.0 -0.5 -0.6 -0.4 -0.5
Tense / ‘highly strung’ 7.1 11.7 15.1 -3.7 -3.4 -3.7 3.6 0.7 3.8 3.7 -2.7 3.8 3.4 3.4 3.9
Seen doctor (GP) for nerves, anxiety, tension or depression 2.9 4.5 6.4 -2.4 -1.7 -2.5 2.1 -1.1 2.2 2.3 -2.4 2.1 2.5 1.7 2.1
Hair/balding pattern: Pattern 4 0.7 1.8 2.9 -1.3 -1.6 -1.4 1.0 -0.6 1.6 1.6 -1.0 1.3 1.7 1.1 1.3
Birth weight of first child 2.9 5.3 7.5 -2.6 -2.2 -2.3 2.2 -0.5 2.2 2.7 -2.2 2.6 2.3 2.4 2.7
Peak expiratory flow (PEF) 0.1 0.2 0.5 -0.4 -0.7 -0.6 0.2 0.2 0.4 0.7 -0.3 0.5 0.6 0.4 0.6
Pulse wave reflection index 1.4 1.7 3.1 -1.1 -1.4 -1.8 1.1 1.2 1.0 1.7 -0.4 1.6 0.7 1.6 1.5
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.0 -1.4 -0.4 -0.6 0.7 0.8 1.7 1.3 -0.3 1.3 0.7 1.5 1.3
Loud music exposure frequency 0.4 0.4 2.1 -0.2 -1.0 0.0 -0.2 1.4 0.9 0.4 0.8 0.1 0.4 0.5 0.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.6 0.7 0.5 0.8 -1.2 -0.2 -0.4 -0.9 1.3 -1.2 -0.6 -1.1 -1.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.7 -0.7 -0.3 -0.3 -0.4 0.0 0.8 0.5 0.0 0.2 0.4 0.1 0.1
Blood clot in the leg (DVT) 0.6 0.8 1.6 1.2 0.8 0.6 0.1 -0.4 -0.8 -1.1 1.0 -1.0 -1.0 -1.2 -0.9
Medication: Paracetamol 0.9 1.5 3.9 1.1 0.9 1.3 -0.7 2.0 -0.7 -1.3 1.1 -1.0 -1.9 -0.9 -1.1
Headache pain in last month 0.2 0.3 1.7 -0.5 -0.5 0.3 0.1 1.3 0.5 0.6 0.1 0.6 0.2 0.7 0.6
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 5.2 0.5 0.1 0.8 -0.9 2.0 -0.8 -0.4 2.3 -0.4 -1.6 -0.3 -0.4
Glaucoma (self-reported) 0.3 0.3 0.9 -0.3 0.6 0.1 -0.7 0.8 -0.2 0.4 1.0 0.2 -0.9 0.1 -0.1
Gout (self-reported) 2.8 3.8 6.9 2.3 2.6 2.0 -2.2 0.4 -2.1 -2.0 1.2 -2.0 -1.6 -1.8 -2.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.3 5.6 -1.1 -1.1 -0.6 1.1 2.4 0.8 0.9 0.6 1.2 -0.2 1.1 1.1
Medication: Amlodipine 0.3 0.4 1.8 0.7 1.4 0.2 -1.0 -0.1 -0.7 -0.2 -0.4 -0.3 -0.6 -0.5 -0.6
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.8 0.4 0.9 0.5 -0.8 0.4 -0.8 -0.4 -0.1 -0.4 -0.4 -0.2 -0.3
Birth weight 3.2 7.0 10.5 -2.8 -3.0 -2.5 3.2 -0.1 2.2 2.9 -2.1 3.0 2.0 3.0 3.2
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.4 0.2 0.3 0.2 -0.7 0.6 -0.1 -0.1 -0.1 -0.2 0.0 0.0 -0.2
High blood pressure (siblings) 1.3 1.8 7.2 -2.0 -0.7 -0.2 1.9 -0.2 2.7 0.7 -0.5 1.0 0.8 1.5 1.2
Forced vital capacity (FVC), Best measure 0.2 0.7 1.5 0.9 0.6 0.5 -1.2 -0.7 -1.0 -0.7 0.5 -1.1 -0.1 -1.2 -1.1
Body fat percentage 1.1 4.2 8.3 2.4 2.5 2.1 -1.2 -0.3 -2.0 -2.9 0.0 -2.4 -1.5 -2.3 -2.4
Leg fat percentage (right) 1.2 4.5 8.6 2.4 2.5 2.7 -1.6 0.1 -1.7 -2.9 0.8 -2.5 -1.6 -2.1 -2.5
Arm fat-free mass (right) 0.2 0.9 1.8 1.1 1.1 1.0 -0.9 -0.6 -0.9 -1.1 0.1 -1.1 -0.5 -1.3 -1.2
Exposure to tobacco smoke outside home 2.4 3.2 4.9 2.1 2.2 2.0 -2.1 0.2 -1.6 -1.9 1.4 -1.9 -1.5 -1.6 -1.9
Comparative body size at age 10 0.2 0.7 1.2 -0.9 -0.9 -1.1 0.1 -0.5 0.9 1.0 -0.6 0.7 0.9 0.7 0.7
Number of full brothers 0.4 0.5 2.4 -0.5 -0.7 0.5 0.3 1.5 1.2 0.2 0.9 0.2 -0.3 0.2 0.2
Worry too long after embarrassment 0.8 1.3 6.0 0.5 0.1 0.9 -1.5 2.4 0.1 0.1 2.2 -0.3 -1.0 0.2 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.2 2.9 4.5 -1.9 -1.6 -1.9 1.5 0.3 2.1 2.1 -1.2 1.8 1.7 1.7 1.7
Wheeze or whistling in the chest in last year 0.1 0.1 0.4 -0.2 -0.4 0.3 0.6 0.3 0.6 -0.2 -0.5 0.0 -0.1 0.5 0.2
Number of children fathered 0.4 0.4 0.9 0.6 0.5 0.6 -0.1 -0.6 -0.6 -1.0 -0.9 -0.7 0.2 -0.8 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.9 -0.1 0.4 0.3 -0.0 1.1 -0.0 0.0 1.0 0.2 -1.4 0.0 0.1
Age at first live birth 1.7 3.0 4.6 -2.1 -2.0 -1.7 2.0 0.2 1.7 1.8 -0.9 1.9 0.8 2.2 2.1
Pulse wave peak to peak time 0.3 0.3 0.9 0.2 0.6 0.6 -0.8 -0.1 -0.2 -0.4 0.7 -0.7 -0.5 -0.9 -0.7
Health satisfaction 0.2 0.2 0.6 0.3 0.8 0.5 -0.7 0.4 -0.5 -0.5 0.1 -0.4 -0.3 -0.2 -0.5
Shortness of breath walking on level ground 0.2 0.3 1.9 0.1 -0.7 -0.4 0.3 -1.4 -0.0 -0.2 -0.6 -0.2 0.2 -0.0 0.0
Qualifications: College or University degree 1.8 5.7 10.2 -2.4 -1.9 -3.2 2.5 -1.3 1.8 2.7 -2.4 2.7 2.4 2.1 2.7
Eye problems/disorders: None of the above 1.2 1.4 6.6 0.4 -0.2 1.4 0.6 2.6 0.6 -1.0 2.1 -0.6 -1.4 -0.1 -0.4
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.7 1.2 1.6 1.2 -0.6 0.7 -1.0 -1.4 1.1 -1.1 -1.3 -1.1 -1.1
Emphysema/chronic bronchitis 0.2 0.3 1.5 -0.6 0.0 -0.3 0.3 0.4 0.5 0.4 0.2 0.6 -0.0 1.2 0.6
Medication for pain relief, constipation, heartburn 0.2 0.3 0.9 0.6 0.7 0.3 -0.4 -0.7 -0.9 -0.4 0.3 -0.4 -0.2 -0.4 -0.4
Neck or shoulder pain in last month 0.2 0.2 0.5 0.1 0.5 0.5 0.7 0.1 0.5 -0.7 0.4 -0.5 -0.0 -0.3 -0.4
Medication: Blood pressure 0.2 0.4 1.9 0.2 0.4 0.1 -0.0 -1.4 0.4 -0.3 -1.1 -0.3 0.8 -0.2 -0.3
Angina (self-reported) 1.4 1.9 4.7 -1.1 -1.3 -1.8 1.1 -1.1 1.2 1.3 -2.2 1.2 1.8 0.6 1.2
Migraine (self-reported) 0.2 0.2 0.6 -0.2 0.1 -0.2 -0.4 0.0 0.3 0.7 -0.5 0.7 0.6 0.5 0.5
Medication: Ibuprofen 0.2 0.2 0.7 0.5 0.1 0.0 -0.5 0.4 -0.2 -0.5 0.0 -0.7 0.2 -0.8 -0.6
Medication: Allopurinol 3.1 4.1 6.6 2.4 2.0 2.6 -2.2 1.6 -1.6 -1.9 2.4 -1.9 -2.1 -1.1 -2.0
Medication: Omeprazole 1.0 1.2 4.5 0.8 0.1 1.3 0.3 0.6 -0.0 -1.3 2.1 -1.2 -1.4 -0.9 -1.0
Medication: Seretide 50 evohaler 0.2 0.3 1.0 0.3 0.1 0.4 -0.2 -0.9 -0.2 -0.3 -0.7 -0.4 1.0 -0.4 -0.3
Mean time to correctly identify matches 0.1 0.3 0.6 0.3 0.4 -0.8 0.8 0.2 -0.5 -0.1 -0.5 0.1 -0.7 -0.8 -0.1
Heart disease (mother) 0.1 0.2 0.5 0.3 -0.1 0.5 -0.1 0.3 0.1 -0.6 0.5 -0.7 0.2 -0.5 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.6 4.3 7.7 1.9 2.2 2.5 -1.6 2.6 -1.7 -1.9 2.7 -1.7 -2.8 -0.8 -1.6
Whole body fat mass 1.1 4.4 8.0 2.4 2.7 2.2 -1.4 -0.2 -2.1 -2.8 0.1 -2.4 -1.7 -2.4 -2.5
Leg fat mass (right) 1.0 3.8 6.4 2.2 2.5 2.2 -1.6 -0.1 -1.9 -2.5 0.2 -2.2 -1.4 -2.2 -2.3
Arm predicted mass (right) 0.2 0.9 1.8 1.0 1.0 0.9 -0.9 -0.7 -0.9 -1.0 -0.1 -1.1 -0.4 -1.3 -1.1
Pulse rate, automated reading 1.4 4.6 9.8 1.9 3.1 2.6 -2.1 0.3 -1.9 -2.5 1.6 -2.4 -1.5 -2.0 -2.4
Alcohol intake frequency. 0.4 0.9 2.1 0.8 1.2 0.7 -1.1 1.3 -1.3 -0.4 0.6 -0.3 -1.4 -0.7 -0.6
Comparative height size at age 10 0.0 0.1 0.4 -0.3 0.6 0.0 -0.4 -0.4 0.5 0.1 0.5 -0.2 0.3 0.4 -0.1
Number of full sisters 1.2 1.5 4.4 0.5 0.8 1.1 -1.2 2.1 -0.6 -0.9 2.0 -0.8 -1.9 -0.4 -0.8
Suffer from ‘nerves’ 3.5 5.6 10.0 -2.7 -2.2 -1.9 1.8 0.9 2.9 2.7 -1.2 2.7 2.1 3.2 2.8
Overall health rating 0.4 0.8 2.4 0.2 0.7 1.6 -0.6 1.5 0.1 -1.0 0.9 -0.9 -0.7 0.1 -0.7
Chest pain or discomfort 0.1 0.2 0.8 -0.1 -0.7 -0.4 0.1 -0.9 0.5 -0.3 -0.3 -0.5 0.5 -0.1 -0.2
Had major operations 0.3 0.3 0.8 0.7 -0.2 0.3 -0.1 0.9 -0.1 -0.6 0.9 -0.6 -0.5 -0.4 -0.5
Age at last live birth 1.5 2.2 3.5 -1.9 -1.5 -1.4 1.8 0.5 1.6 1.6 -0.4 1.7 0.6 1.8 1.8
Family relationship satisfaction 1.6 2.0 4.4 -1.4 -1.5 -1.1 1.5 0.3 1.5 1.4 -0.8 1.5 1.4 2.1 1.8
Leg pain on walking 0.5 0.7 1.7 0.7 0.6 0.4 0.2 -0.5 -0.8 -1.3 0.3 -0.9 -1.2 -1.0 -0.9
Qualifications: NVQ or HND or HNC or equivalent 4.6 5.6 9.1 2.9 2.7 1.9 -2.7 -0.1 -2.5 -2.5 1.3 -2.6 -1.4 -3.0 -2.7
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.4 -1.0 -0.6 -0.3 0.4 0.4 0.6 0.6 -0.3 0.7 0.2 1.2 0.8
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 2.4 0.9 0.5 0.2 -0.2 -0.3 -1.2 -1.2 0.0 -1.0 -1.0 -1.5 -1.1
Medication: Aspirin 0.4 0.6 2.2 -0.3 -0.7 -0.8 0.0 -1.4 0.2 0.2 -1.5 0.1 1.1 -0.1 0.1
Supplements: Vitamin C 1.2 1.4 4.2 -0.6 -2.1 -1.1 2.0 -1.0 0.6 0.6 -1.0 0.8 1.4 0.9 1.1
Knee pain experienced in last month 0.2 0.4 1.1 0.6 0.5 0.9 0.1 1.1 -0.1 -0.7 0.4 -0.4 -0.8 -0.4 -0.4
Hypertension (Self-reported) 0.2 0.5 1.4 0.5 1.2 1.1 0.2 0.0 0.5 -1.1 0.5 -0.8 -0.5 -0.5 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 3.0 4.6 -1.9 -1.5 -2.1 1.0 -0.8 1.5 2.0 -1.9 1.8 2.2 1.6 1.8
Illnesses of father: Heart disease 5.8 8.0 15.7 -3.0 -2.8 -2.8 1.8 -2.5 3.0 2.9 -3.5 2.5 4.0 2.1 2.6
Illnesses of siblings: Diabetes 8.5 10.4 14.4 3.4 3.1 3.0 -3.1 0.9 -3.5 -3.8 2.7 -3.6 -3.1 -3.8 -3.8
Smoking status: Previous 0.3 0.4 1.6 0.9 0.2 0.1 -0.5 -1.3 -0.6 -0.6 -0.3 -0.6 -0.3 -0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.5 -0.1 -0.1 0.2 -0.7 0.5 -0.2 0.4 0.5 0.2 -0.1 0.6 0.2
Whole body fat-free mass 0.0 0.2 0.5 0.4 0.7 0.2 -0.5 -0.4 -0.4 -0.3 -0.4 -0.3 -0.2 -0.7 -0.5
Leg fat-free mass (right) 0.1 0.4 0.9 0.6 0.9 0.1 -0.8 -0.4 -0.9 -0.4 -0.6 -0.4 -0.5 -0.8 -0.6
Arm fat percentage (left) 0.7 2.7 4.8 1.9 2.2 1.9 -1.0 0.3 -1.5 -2.2 0.2 -1.7 -1.5 -1.8 -1.9
Average weekly red wine intake 0.1 0.2 0.5 0.1 -0.3 0.4 0.7 0.3 0.5 -0.6 0.3 -0.3 0.1 -0.2 -0.2
Handedness (chirality/laterality): Left-handed 3.4 4.1 6.8 -2.3 -1.1 -2.3 1.5 0.8 1.5 2.6 -1.9 2.5 2.0 2.4 2.4
Mood swings 0.5 1.0 2.1 -0.7 -1.1 -0.8 1.1 -0.4 1.0 0.8 -1.1 0.9 1.5 1.1 1.1
Loneliness, isolation 1.0 1.4 3.5 -1.4 -1.3 -0.6 0.7 1.3 1.6 1.4 0.2 1.2 0.0 1.9 1.3
Long-standing illness, disability or infirmity 0.9 1.4 2.4 -1.4 -1.0 -1.1 0.8 -0.5 1.4 1.4 -1.1 1.1 1.1 1.6 1.1
Ever had bowel cancer screening 0.9 1.1 4.8 -0.5 -0.1 -1.1 -0.1 -2.2 0.1 0.5 -2.0 0.2 1.6 -0.2 0.1
Diabetes diagnosed by doctor 4.8 7.8 11.8 3.1 3.4 2.9 -3.4 0.6 -3.0 -2.9 1.4 -3.0 -2.5 -2.8 -3.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.7 0.0 0.0 1.0 -0.2 0.6 0.5 -0.3 1.3 -0.3 -0.9 0.7 -0.2
Friendships satisfaction 3.2 4.0 6.7 -2.3 -1.5 -2.3 1.3 0.4 1.7 2.6 -1.7 2.3 2.3 2.1 2.4
Qualifications: nursing, teaching 1.2 1.9 3.3 -1.1 -1.1 -1.7 1.8 -1.8 1.2 1.0 -1.4 1.1 1.8 0.7 1.1
Commuting to job workplace: Walk 2.1 2.3 3.7 1.5 1.9 1.5 -1.9 0.3 -1.8 -1.7 1.3 -1.7 -1.0 -1.1 -1.7
Eye problems/disorders: Cataract 0.5 0.6 2.3 -0.3 0.3 -0.9 -0.4 -1.1 -0.1 0.8 -1.5 0.6 0.9 0.4 0.4
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 -0.3 0.4 -0.6 -0.6 -0.1 0.1 0.6 -0.3 0.4 0.5 0.2 0.2
Medication for cholesterol 0.7 1.1 1.9 -1.1 -1.4 -0.8 1.1 0.1 1.1 1.0 -0.9 1.0 1.3 1.1 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.7 -0.1 -0.3 0.8 -0.3 1.3 0.4 -0.1 0.9 -0.0 -0.6 0.5 0.1
Back pain experienced in last month 1.1 1.6 2.7 -1.1 -1.3 -1.0 1.3 0.1 1.6 1.2 -1.5 1.3 1.4 1.2 1.4
Mineral and other dietary supplements 0.6 0.9 2.6 0.6 0.5 -0.3 -1.1 -1.6 -1.4 -0.0 -1.5 -0.2 1.2 -0.4 -0.2
Breast cancer (self-reported) 0.9 1.0 3.8 -0.2 -0.9 -0.9 1.1 -1.9 0.4 0.3 -2.0 0.6 1.2 -0.0 0.6
Asthma (self-reported) 2.3 4.5 6.0 -2.2 -2.4 -2.2 1.6 -0.4 2.1 2.3 -2.5 2.3 2.2 2.2 2.3
Osteoporosis (self-reported) 0.1 0.2 0.9 -0.3 -0.4 -0.6 0.9 0.0 -0.2 0.1 -0.2 0.3 -0.3 0.2 0.2
Osteoarthritis (self-reported) 1.0 1.2 2.1 1.4 1.0 1.1 -0.3 1.2 -0.8 -1.2 1.1 -0.9 -1.5 -1.3 -1.1
Medication: Aspirin 0.2 0.3 0.7 0.4 0.0 0.1 -0.6 -0.9 -0.3 -0.6 -0.6 -0.7 0.3 -0.7 -0.6
Medication: Gliclazide 4.1 4.7 11.4 2.2 2.2 2.6 -3.4 1.9 -2.2 -1.6 2.3 -1.9 -2.0 -0.9 -1.9
Illnesses of father: None of the above (group 1) 0.4 0.5 2.7 0.6 0.1 -0.7 -0.5 -1.2 -1.6 -0.1 -0.5 -0.3 -0.2 -0.8 -0.5
Smoking status: Current 5.4 8.6 12.9 3.6 2.8 3.1 -2.0 1.1 -3.1 -3.6 2.1 -3.3 -3.0 -3.3 -3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.9 1.3 1.0 0.7 -0.9 -0.0 -1.2 -0.8 1.0 -1.0 -0.4 -1.7 -1.2
Whole body water mass 0.0 0.2 0.5 0.4 0.7 0.3 -0.6 -0.3 -0.4 -0.3 -0.3 -0.4 -0.2 -0.7 -0.5
Leg predicted mass (right) 0.1 0.4 0.9 0.6 1.0 0.1 -0.8 -0.4 -1.0 -0.4 -0.6 -0.4 -0.5 -0.9 -0.6
Arm fat mass (left) 0.7 2.7 5.2 1.9 2.3 1.9 -1.2 0.0 -1.6 -2.1 -0.0 -1.8 -1.3 -1.9 -1.9
Number of self-reported non-cancer illnesses 0.1 0.1 0.6 -0.2 -0.1 -0.1 0.4 0.8 0.6 0.2 -0.2 0.3 0.2 0.4 0.3
Average weekly champagne plus white wine intake 1.2 1.7 2.5 -1.4 -1.6 -1.5 1.5 -1.3 1.4 1.2 -1.0 1.2 1.3 0.9 1.3
Miserableness 1.0 1.8 3.1 -1.4 -1.4 -0.9 1.6 0.6 1.6 1.4 -0.3 1.4 1.3 1.8 1.6
Guilty feelings 0.8 1.2 4.8 -1.0 -0.7 0.2 1.0 1.2 2.2 0.6 1.3 0.6 -0.1 1.5 0.9
Wears glasses or contact lenses 7.1 8.2 11.4 -3.1 -2.9 -3.2 2.2 -1.0 2.3 3.4 -3.1 3.1 3.0 3.0 3.2
Ever taken oral contraceptive pill 0.4 0.5 1.7 0.7 0.3 0.2 -0.7 -1.3 -0.7 -0.3 -1.1 -0.6 0.2 -0.5 -0.5
Hearing aid user 1.2 1.4 3.2 -1.0 -1.8 -1.5 1.1 -1.4 0.3 1.0 -1.4 0.9 1.0 0.8 1.0
Mother’s age at death 1.9 2.3 5.8 -0.9 -1.1 -1.6 1.7 -2.4 0.5 1.1 -2.4 1.2 2.0 0.6 1.2
Financial situation satisfaction 0.4 0.5 1.8 0.2 1.3 1.1 -0.8 1.3 0.2 0.1 0.8 0.1 -0.5 0.7 -0.0
Tinnitus: Yes, now most or all of the time 4.8 5.6 9.7 -2.4 -2.7 -3.1 2.1 -0.5 1.9 2.8 -2.1 2.6 2.6 1.9 2.6
Commuting to job workplace: Public transport 0.4 0.4 0.9 -0.4 -0.7 -0.5 1.0 -0.3 0.5 0.6 -0.7 0.7 0.8 0.7 0.8
Eye problems/disorders: Glaucoma 0.3 0.3 0.9 -0.5 -0.0 -1.0 -0.7 0.1 -0.6 1.0 0.1 0.6 -0.5 0.2 0.3
Medication: Blood pressure 0.8 1.6 2.7 1.4 1.3 1.1 -0.5 -0.6 -1.4 -1.7 0.6 -1.5 -1.2 -1.6 -1.5
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.9 0.4 1.4 0.4 0.5 0.4 -0.2 -0.9 -0.3 -0.3 -0.7 -0.4 -0.4
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.0 -0.2 -0.4 0.5 0.9 1.5 1.1 -0.2 1.7 -0.0 -1.4 0.1 0.0
High cholesterol (Self-reported) 0.2 0.3 1.3 0.3 1.1 -0.1 -0.1 -0.7 -0.2 -0.1 -1.1 -0.0 0.6 -0.4 -0.2
Medication: Bendroflumethiazide 1.2 1.8 2.7 1.6 1.3 1.4 -0.7 -0.5 -1.3 -1.5 1.3 -1.5 -1.3 -1.6 -1.5
Medication: Paracetamol 1.1 1.7 3.0 1.3 1.2 1.5 -0.7 1.2 -0.7 -1.7 0.9 -1.5 -1.7 -1.2 -1.4
Medication: Lisinopril 1.0 1.2 2.5 1.1 0.8 0.9 -1.1 -1.6 -1.1 -1.3 -0.2 -1.4 -0.0 -1.2 -1.4
Medication: Atorvastatin 0.3 0.4 1.6 -0.4 0.0 -0.4 0.8 -0.9 0.7 0.0 -1.3 0.2 0.9 -0.1 0.2
Illnesses of father: High blood pressure 0.3 0.4 1.7 -0.3 0.3 0.6 -0.7 1.3 0.7 0.1 1.2 -0.2 -0.4 0.5 -0.1
Alcohol drinker status: Never 2.4 2.9 7.0 2.1 1.8 1.4 -1.8 0.4 -2.6 -1.6 1.1 -1.5 -1.8 -1.7 -1.6
Ever smoked 1.4 2.5 5.2 2.1 1.5 0.9 -0.5 -1.7 -1.8 -2.1 -0.3 -1.7 -0.8 -2.3 -1.8
Basal metabolic rate 0.1 0.7 1.3 0.9 1.1 0.8 -0.9 -0.2 -0.8 -0.9 -0.1 -0.9 -0.6 -1.1 -1.0
Leg fat percentage (left) 1.7 6.1 11.5 2.8 2.9 3.0 -1.9 -0.2 -2.1 -3.4 0.9 -3.0 -1.9 -2.6 -3.0
Arm fat-free mass (left) 0.2 0.8 1.6 1.0 1.3 0.8 -0.9 -0.5 -1.0 -1.0 -0.4 -1.0 -0.3 -1.2 -1.0
Number of operations (self-reported) 0.2 0.3 0.8 -0.2 -0.3 -0.5 0.9 0.9 0.2 0.3 -0.2 0.6 0.1 0.6 0.6
Average weekly beer plus cider intake 1.2 1.8 5.0 0.9 0.8 0.8 -1.6 1.6 -1.2 -1.1 1.7 -1.2 -2.2 -1.0 -1.3
Irritability 0.4 0.8 1.2 -0.7 -0.6 -0.6 1.1 0.5 0.9 0.7 -1.0 0.9 1.0 1.0 1.0
Risk taking 0.8 1.2 7.0 0.7 -0.7 -0.3 0.9 -2.6 -0.3 -0.8 -1.2 -0.7 0.4 -1.4 -0.5
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.5 -0.9 -0.9 -0.9 0.7 0.3 0.8 1.2 -0.0 1.0 0.4 1.2 1.0
Fractured/broken bones in last 5 years 1.7 2.2 3.1 -1.7 -1.0 -1.4 1.6 -1.0 1.7 1.5 -1.1 1.7 1.5 1.4 1.8
Age started oral contraceptive pill 1.5 1.9 7.4 -0.6 -0.2 -1.5 0.9 -2.5 -0.6 0.5 -2.7 0.6 2.1 -0.0 0.6
Diastolic blood pressure, automated reading 0.1 0.3 0.8 -0.3 -0.8 0.7 0.1 -0.9 0.9 -0.3 0.5 -0.4 0.5 0.2 -0.1
Ever depressed for a whole week 0.7 0.8 1.7 -1.0 0.3 -0.6 0.4 0.8 0.7 1.2 -0.6 1.3 0.9 1.2 1.2
Unable to work because of sickness or disability 0.5 0.6 2.6 0.7 1.1 0.3 -1.6 0.1 -1.2 -0.2 0.3 -0.5 -0.7 -0.5 -0.7
Commuting to job workplace: Cycle 0.4 0.5 1.7 -0.7 -1.3 -0.7 0.3 -0.2 1.0 1.0 -0.2 0.6 0.6 0.4 0.6
Myopia 0.3 0.4 1.4 0.4 0.2 0.5 -0.3 1.2 -0.2 -0.4 1.1 -0.4 -0.9 0.1 -0.3
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.7 -0.2 -0.9 -0.8 -0.1 0.5 -0.8 0.8 -0.1 0.6 -0.1 0.3 0.6
Cholesterol lowering medication 0.4 0.6 1.2 1.1 1.1 0.6 -0.4 -0.2 -1.0 -1.0 -0.1 -0.9 -0.3 -1.1 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.9 0.4 -0.1 1.0 0.5 0.1 0.2 -1.0 1.4 -0.9 -0.8 -0.5 -0.7
Pain experienced in last month 0.7 1.2 2.9 1.1 0.6 0.7 -1.7 -0.5 -1.3 -0.9 1.4 -1.2 -1.1 -1.0 -1.2
Supplements: Calcium 0.2 0.2 1.2 -0.1 -0.6 -0.6 1.1 0.2 -0.3 -0.1 0.1 0.2 -0.4 0.1 0.2
Basal cell carcinoma (self-reported) 0.3 0.3 1.0 -0.5 -0.1 -0.4 -0.2 -0.4 0.1 0.8 -0.7 0.6 1.0 0.8 0.6
Heart attack/myocardial infarction (self-reported) 2.3 3.0 6.9 -2.0 -2.0 -1.0 1.4 0.6 2.6 1.5 -0.7 1.5 1.8 2.4 1.8
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.3 1.1 0.8 0.6 0.2 -0.1 -0.6 -1.0 1.0 -0.9 -0.9 -1.0 -0.8
Heart disease (siblings) 0.9 1.1 2.5 -1.2 -1.5 -1.2 0.6 0.4 0.8 1.6 -0.2 1.4 0.1 1.1 1.2
Alcohol drinker status: Previous 1.2 1.4 2.7 0.7 1.4 1.6 -1.6 1.2 -0.7 -1.2 1.1 -1.2 -1.1 -0.5 -1.1
Pack years of smoking 0.1 0.2 0.5 -0.4 0.6 -0.1 0.0 0.7 0.1 0.2 -0.7 0.4 0.3 0.6 0.4
Impedance of whole body 0.0 0.1 0.4 0.2 -0.1 0.0 -0.1 -0.0 -0.3 -0.4 0.6 -0.5 -0.1 0.1 -0.3
Leg fat mass (left) 1.2 4.6 7.4 2.5 2.7 2.4 -1.9 -0.1 -2.1 -2.7 0.3 -2.4 -1.6 -2.4 -2.6
Arm predicted mass (left) 0.2 0.8 1.4 1.0 1.1 0.8 -0.8 -0.6 -0.9 -1.0 -0.3 -1.0 -0.2 -1.2 -1.0