Hub : Genes

DNAJC13

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0540 0.0230 7.0e-03 0.057 0.005 0.045 0.039 0.053 1.5e-07 0.08000 3.3e-06 1.3e-05 4.8e-07
2 GTEx Adrenal Gland 0.2980 0.0785 6.5e-05 0.012 NA 0.050 NA 0.009 1.2e-01 NA 6.8e-03 NA 1.5e-01
3 GTEx Breast Mammary Tissue 0.1490 0.0550 1.4e-03 0.018 NA 0.027 NA -0.002 4.0e-02 NA 1.5e-02 NA 4.1e-01
4 GTEx Breast Mammary Tissue (Male) 0.1058 0.0995 1.8e-01 0.004 NA -0.008 NA -0.013 2.5e-01 NA 5.2e-01 NA 9.0e-01
5 GTEx Breast Mammary Tissue (Female) 0.1089 0.0746 8.4e-02 0.004 NA -0.002 NA 0.018 2.3e-01 NA 3.7e-01 NA 9.1e-02
6 GTEx Esophagus Mucosa 0.1140 0.0400 3.0e-04 0.011 NA 0.031 NA 0.013 5.3e-02 NA 3.8e-03 NA 4.2e-02
7 GTEx Esophagus Muscularis 0.1280 0.0450 5.9e-04 0.062 NA 0.091 NA 0.090 1.3e-04 NA 3.5e-06 NA 3.9e-06
8 GTEx Testis 0.3390 0.0760 7.6e-06 0.215 NA 0.208 NA 0.223 6.6e-10 NA 1.3e-09 NA 2.9e-10
9 METSIM Adipose 0.0669 0.0241 2.2e-04 0.053 0.021 0.037 0.029 0.039 1.9e-08 0.00034 2.5e-06 3.0e-05 1.3e-06
10 YFS Blood 0.0495 0.0162 3.2e-06 0.013 0.011 0.022 0.016 0.026 3.4e-05 0.00015 6.2e-08 3.3e-06 5.6e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.2 0.4 1.2 0.9 0.4 0.7 0.0 1.1 -0.3 0.4 -0.9 -0.4 -0.1
Bipolar Disorder or Schizophrenia 0.1 0.2 0.6 -0.8 -0.6 0.3 0.0 0.4 -0.7 -0.1 -0.1 -0.5 -0.6
Depressed Affect (Nagel 2018) 0.4 0.9 5.2 -0.8 -2.3 -0.3 0.0 1.1 -1.3 -0.3 0.0 -0.4 -0.2
Depression (Nagel 2018) 0.5 0.7 2.5 -1.4 -1.6 -1.0 0.0 0.2 -1.1 -0.2 -0.5 0.2 0.1
Intelligence (Savage-Jansen 2018) 2.3 7.1 17.9 -1.3 1.4 4.2 0.0 3.5 2.5 2.7 3.3 0.9 3.5
Neuroticism (Nagel 2018) 0.3 0.8 4.3 -0.9 -2.1 -0.8 0.0 0.7 -0.9 0.2 -0.4 0.5 0.2
Schizophrenia (2018) 0.3 0.6 3.0 -1.7 -1.2 -0.1 0.0 -0.3 -0.7 -0.5 0.5 -0.4 -0.6
Schizophrenia vs Biploar Disorder 1.1 1.5 7.9 -2.8 -1.3 -0.5 0.0 -1.8 -0.4 -0.6 1.1 0.4 0.1
Worry (Nagel 2018) 0.3 0.7 3.0 -1.0 -1.0 -0.8 0.0 -0.3 -0.7 0.3 -0.6 1.7 0.6
Alzheimer’s Disease (in mother) 0.4 0.5 2.2 -1.0 0.1 0.2 0.0 -0.4 -0.0 0.8 0.4 -1.5 -0.8
Alzheimer’s Disease (in father) 0.9 1.0 3.8 -0.1 -1.0 1.5 0.0 0.9 0.6 0.9 1.9 -0.5 0.9
Alzheimer’s Disease (including proxy) 0.8 1.2 3.2 -0.7 0.1 1.8 0.0 1.2 0.7 1.5 1.5 -1.3 0.2
Crohns Disease (2017) 0.7 1.5 5.3 -0.0 1.5 0.8 0.0 0.1 2.1 2.3 -1.4 -0.2 0.1
Irritable Bowel Disease (IBD) 0.6 1.5 6.5 -0.9 1.1 1.1 0.0 0.6 2.0 2.5 -0.5 0.4 0.9
Ulcerative Colitis (UC) 0.4 0.7 2.6 -1.2 -0.2 0.6 0.0 0.5 1.0 1.6 0.2 0.6 0.9
Major Depression (MDD) 0.2 0.2 0.9 0.1 0.0 -0.0 0.0 0.6 -0.4 0.1 -0.1 -0.9 -0.9
Reaction Time 1.5 2.8 11.8 2.0 1.4 0.2 0.0 0.8 0.2 1.5 -1.6 3.4 2.2
Verbal and Numeric Reasoning (VNR) 2.3 5.4 13.8 -2.0 1.0 3.5 0.0 2.6 1.7 2.1 3.7 0.2 2.9
Breast Cancer 0.2 0.5 2.0 0.8 -1.0 -0.2 0.0 -0.5 -0.2 -1.4 -0.9 -0.3 -0.4
Ovarian Cancer 0.6 0.8 2.1 -0.8 -0.1 1.3 0.0 0.6 0.1 1.1 0.7 1.0 1.4
Prostate Cancer 2.6 3.6 16.5 0.6 -1.9 -1.4 0.0 -0.4 -0.7 -1.8 -0.7 -4.1 -3.1
Age at First Birth 0.6 0.9 4.8 -1.0 -2.2 0.7 0.0 0.2 -0.2 -0.3 1.1 1.0 0.8
Bipolar Disorder (2011) 0.8 0.8 2.4 -1.3 0.7 0.5 0.0 1.6 0.8 0.4 0.9 0.7 1.0
Body Mass Index (BMI) (2010) 0.6 0.8 2.7 1.6 0.8 -0.3 0.0 0.6 0.9 0.8 -1.4 0.1 1.1
Coronary Artery Disease (CAD) 1.6 1.9 5.0 0.5 2.2 0.2 0.0 2.1 2.2 2.0 -0.5 -0.3 0.8
Crohns Disease (2012) 1.9 3.1 10.5 0.7 3.2 0.3 0.0 -0.7 1.5 2.7 -3.1 -0.4 -0.7
Mean Putamen Volume 0.3 0.4 1.3 -0.2 0.4 0.7 0.0 -0.8 0.5 0.3 -1.2 0.9 0.1
Fasting Glucose 0.4 0.5 2.6 0.6 -0.7 0.6 0.0 -0.7 -1.6 -0.4 -0.2 0.2 -0.4
HbA1C 0.4 0.4 1.2 -0.5 -0.5 -0.7 0.0 -0.3 -0.5 -0.8 -0.5 -0.8 -1.1
HDL Cholesterol 1.1 1.8 6.2 -0.5 -0.5 -1.3 0.0 -1.6 -1.5 -0.4 -1.5 -1.5 -2.5
LDL Cholesterol 2.1 3.3 6.6 2.2 2.2 -0.4 0.0 1.4 2.5 2.6 -1.5 -2.1 -1.4
Lupus 0.1 0.2 1.1 0.2 -0.3 -0.4 0.0 -1.1 -0.3 -0.6 0.1 -0.1 -0.4
Neuroticism (2016) 0.2 0.2 0.8 -0.6 -0.2 -0.3 0.0 -0.6 -0.9 -0.3 0.3 0.1 -0.7
Primary Biliary Cirrhosis 0.3 0.4 2.0 0.3 1.1 0.5 0.0 0.3 -0.6 0.5 -0.1 -1.4 -0.6
Rheumatoid Arthritis 1.6 2.2 6.7 -0.6 1.0 -2.1 0.0 -2.1 -0.8 -0.4 -1.0 -1.8 -2.6
Schizophrenia (2014) 0.6 1.2 6.7 -2.6 -0.7 1.4 0.0 1.1 -0.0 0.3 1.4 -0.3 0.4
Triglycerides 0.7 1.2 3.2 1.0 1.8 -1.1 0.0 -1.4 1.4 0.7 -1.1 -0.4 -0.4
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.5 0.4 -0.5 -0.5 0.0 -0.7 -0.2 -0.2 0.1 0.2 0.6
Ulcerative Colitis 0.4 0.7 4.6 -0.4 0.0 0.6 0.0 0.5 0.6 2.1 -0.8 -0.1 0.4
Blood Eosinophil Count 0.2 1.6 4.3 2.1 -0.3 -0.2 0.0 -0.7 0.5 1.0 -1.6 -2.1 -1.6
Blood Platelet Count 0.3 3.7 11.9 -1.4 -1.6 -1.4 0.0 -2.5 -3.1 -3.5 -1.0 0.8 -1.0
Blood Red Count 0.3 2.7 10.6 2.8 1.0 -1.6 0.0 -1.6 0.6 -0.1 -3.2 0.2 -1.4
Blood White Count 2.2 16.1 35.6 1.5 -3.0 -3.9 0.0 -6.0 -5.7 -5.1 -3.8 -1.6 -4.8
Heel T-Score 0.1 0.9 3.4 -0.7 0.7 0.7 0.0 0.0 1.8 0.7 -0.4 0.7 1.7
BMI 0.5 2.8 12.5 1.3 -0.5 -1.1 0.0 -3.5 -2.2 -0.4 -1.2 1.5 1.9
Height 0.6 10.9 35.0 -1.3 2.0 3.2 0.0 5.9 5.5 3.8 2.2 -0.6 3.0
Waist Hip Ratio (WHR) 0.3 1.2 3.8 2.0 1.3 0.1 0.0 1.5 0.7 1.4 -0.6 0.9 0.9
Systolic Blood Pressure 0.9 4.7 12.0 0.0 1.7 2.9 0.0 2.2 1.7 2.4 0.6 3.0 3.5
Smoking Status 0.5 1.2 7.3 0.3 -0.7 0.1 0.0 0.7 -2.7 -1.0 1.7 -0.2 0.1
Allergy or Eczema 0.1 0.3 1.3 -0.5 0.6 1.1 0.0 -0.9 -0.8 -0.3 -0.1 -0.1 -0.1
Cardiovascular Disease 0.9 2.9 10.1 -0.4 1.7 0.7 0.0 1.0 0.6 3.0 1.3 2.0 3.2
Hypothyroidism (self reported) 0.8 1.8 10.0 3.2 1.2 0.9 0.0 1.1 0.9 1.5 -1.0 -0.8 0.1
Respiratory disease 0.9 1.9 7.3 -1.1 -0.4 -1.4 0.0 -2.4 -2.7 -1.2 -0.6 0.3 -0.8
Type 2 Diabetes (T2D) (2018) 0.7 1.3 4.5 0.1 0.9 -0.8 0.0 -2.1 -0.6 -0.0 0.2 2.0 1.4
Lung FEV1/FVC ratio 0.6 3.1 9.3 1.5 0.9 -2.1 0.0 -1.4 1.8 1.1 -3.0 -2.1 -1.8
Lung FVC 1.7 8.5 25.5 -2.7 -1.1 3.7 0.0 5.0 3.7 2.2 3.8 -0.9 1.9
Neuroticism 0.4 1.0 6.9 -0.8 -2.6 -0.8 0.0 0.4 -0.9 -0.1 0.5 -0.1 0.1
Chronotype (morning person) 0.3 0.7 1.9 -0.9 1.4 -1.1 0.0 -1.1 -1.2 -0.2 -0.4 0.5 -0.5
Hair Pigment 0.0 1.2 4.8 -0.9 -0.1 1.3 0.0 2.2 0.1 0.0 0.9 0.9 1.7
Tanning 0.0 0.5 1.4 -0.2 -1.2 -0.7 0.0 -0.2 0.6 -0.8 -0.7 -0.6 -1.0
Hand grip strength (left) 2.0 5.3 16.8 -3.1 -3.4 -1.5 0.0 -1.9 -2.2 -4.1 0.2 -1.1 -1.6
Number of treatments/medications taken 0.3 0.6 2.6 0.1 0.5 0.2 0.0 -0.1 -0.4 1.1 0.8 0.8 1.6
Average weekly spirits intake 1.1 1.4 4.6 -0.6 -1.0 -1.0 0.0 -0.1 -2.1 -2.2 1.3 0.6 0.6
Sensitivity / hurt feelings 0.3 0.4 1.1 -0.5 -1.0 0.1 0.0 1.0 1.0 0.9 -0.0 -0.4 0.2
Frequency of depressed mood in last 2 weeks 0.6 0.9 3.0 -0.7 -0.6 0.5 0.0 1.7 0.1 1.3 0.4 0.7 1.5
Hearing difficulty/problems: Yes 0.2 0.3 0.9 0.9 0.2 -0.1 0.0 0.9 0.5 0.9 -0.2 -0.2 0.2
Relative age of first facial hair 0.6 1.2 2.9 -1.7 -1.2 1.3 0.0 1.3 0.3 -1.2 1.5 -0.9 0.1
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 3.6 1.5 -0.4 -0.8 0.0 -1.9 -1.8 -0.7 -0.7 0.6 -0.2
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.7 0.7 -0.0 0.9 0.0 1.5 0.6 1.6 0.6 1.4 1.6
Ever had hysterectomy (womb removed) 1.5 1.7 5.0 -0.5 0.2 0.7 0.0 0.6 -1.8 -0.1 2.2 2.2 1.8
Systolic blood pressure, automated reading 0.5 1.4 5.6 0.5 0.9 1.7 0.0 0.5 -0.4 0.6 -0.3 2.4 1.8
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.6 -0.1 1.2 -0.2 0.0 -1.3 -0.4 0.5 -0.2 0.6 -0.3
Angina 0.4 0.6 1.4 1.1 0.8 -0.6 0.0 -0.6 1.0 0.5 -0.1 1.2 0.4
Medication for hormone replacement therapy 0.5 0.5 3.1 0.5 -1.8 -0.1 0.0 -0.2 0.2 1.1 -0.1 -0.8 -0.5
Vitamin and mineral supplements 0.5 0.6 2.3 0.1 0.1 -1.0 0.0 -1.0 -0.2 -1.5 0.0 1.4 -0.3
Supplements: Zinc 0.2 0.2 1.1 0.3 0.2 0.7 0.0 -0.4 0.6 1.0 -0.1 -0.5 0.2
Medication: Co-codamol 0.6 0.7 3.2 1.2 0.4 0.1 0.0 1.8 0.3 0.7 0.2 -0.8 0.6
Medication: Metformin 0.5 0.7 1.6 -0.8 -0.5 -0.7 0.0 -1.1 -0.7 0.0 1.2 1.0 1.3
Diabetes (father) 0.5 0.6 2.5 -1.6 -0.2 -0.7 0.0 -0.9 -0.4 -0.8 0.9 -0.1 -0.4
Diabetes (mother) 0.8 1.0 4.7 2.2 0.5 -0.4 0.0 -1.1 -0.0 0.8 -1.7 0.1 -0.2
Severe depression (siblings) 0.3 0.3 1.6 -0.5 0.2 -0.2 0.0 -1.3 -0.1 0.0 -0.2 1.1 -0.0
Pack years adult smoking proportion 0.5 0.7 2.8 -0.1 -1.0 -1.7 0.0 -0.7 -1.0 0.3 -0.0 -1.2 -0.7
Impedance of leg (right) 1.6 7.8 21.2 -0.1 -1.6 -3.5 0.0 -2.8 -2.4 -3.7 -3.7 -0.7 -4.6
Leg fat-free mass (left) 0.4 2.3 10.5 -0.6 0.1 0.9 0.0 1.2 1.3 1.5 2.3 0.3 3.2
Trunk fat percentage 1.0 4.2 14.8 0.8 -0.8 -2.4 0.0 -3.8 -3.0 -2.5 -2.1 0.3 -0.9
Hand grip strength (right) 1.9 5.1 12.7 -3.5 -3.3 -1.3 0.0 -1.4 -0.9 -3.6 0.5 -2.5 -2.0
Townsend deprivation index at recruitment 0.5 0.8 2.5 0.9 1.2 0.5 0.0 1.6 -0.2 1.1 0.5 -0.8 0.6
Current tobacco smoking 0.3 0.4 1.8 1.4 0.4 -0.2 0.0 1.0 -0.6 0.3 0.7 -0.5 -0.1
Average weekly fortified wine intake 0.4 0.5 2.3 -0.2 -1.5 0.4 0.0 0.1 -0.1 -0.0 1.3 0.4 0.3
Maternal smoking around birth 0.4 0.6 1.6 -0.2 -1.1 1.0 0.0 0.5 0.0 -0.0 1.2 -1.0 0.9
Fed-up feelings 0.9 1.6 9.8 -0.7 -3.1 -0.6 0.0 0.6 -2.1 -0.4 0.7 -0.2 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.6 -0.7 -0.8 -0.4 0.0 0.5 -0.5 0.7 -0.2 -0.6 0.1
Relative age voice broke 0.6 1.0 3.0 -1.7 -0.7 1.4 0.0 1.1 -0.1 -0.7 1.1 1.0 0.7
Taking other prescription medications 0.8 1.2 4.3 1.4 1.5 0.5 0.0 0.2 0.1 2.1 -0.9 0.8 1.2
Age when periods started (menarche) 0.8 2.0 7.5 -1.4 -2.7 -0.5 0.0 -0.0 -0.1 -1.5 1.2 -1.9 -1.6
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 3.4 0.2 -0.3 -0.8 0.0 -0.4 -1.9 -0.8 0.3 0.8 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 2.5 -0.4 1.0 1.6 0.0 0.5 0.4 -0.8 1.2 0.9 1.1
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 6.9 2.6 1.9 -0.7 0.0 0.2 0.6 1.4 -1.7 -0.5 -0.6
Qualifications: CSEs or equivalent 0.6 0.8 2.5 -0.3 -0.5 -1.6 0.0 -1.0 -0.5 -1.4 -0.3 -1.0 -1.1
Serious illness, injury or assault to yourself 0.2 0.3 0.7 0.7 -0.7 -0.6 0.0 -0.8 0.3 0.3 0.3 -0.8 -0.0
High blood pressure 1.2 3.4 11.1 -1.1 1.6 2.1 0.0 1.5 0.9 2.1 1.2 2.4 3.3
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.5 0.1 1.1 1.0 0.0 -1.2 -0.8 -0.3 -0.3 -0.7 -0.6
Multivitamins +/- minerals 0.2 0.3 1.2 -0.1 0.6 -0.1 0.0 0.4 -0.1 1.1 -0.4 -0.8 0.1
Stomach or abdominal pain in last month 0.8 1.0 2.3 0.5 1.3 -0.8 0.0 -0.8 0.8 0.6 -1.0 -1.4 -1.5
Supplements: Glucosamine 0.6 0.8 3.3 -0.7 -1.1 1.8 0.0 1.5 0.4 -0.3 0.7 0.2 0.5
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 4.9 1.7 2.1 0.8 0.0 0.8 1.9 2.2 -1.3 -0.8 -0.4
Medication: Atenolol 2.5 3.1 11.2 0.6 0.4 1.9 0.0 1.5 0.9 1.3 0.7 3.3 3.4
Medication: Levothyroxine sodium 0.4 0.7 5.1 2.3 0.2 0.9 0.0 0.5 -0.8 0.2 -0.8 -0.1 0.0
Sitting height 0.4 3.1 7.6 -2.7 1.3 1.1 0.0 2.8 2.6 0.4 1.9 -0.3 1.4
Chronic bronchitis/emphysema (father) 0.8 1.0 3.0 1.7 0.8 -0.9 0.0 0.2 -0.9 0.8 -1.6 -0.5 -1.0
High blood pressure (mother) 0.6 0.9 3.2 -0.7 -0.3 0.1 0.0 0.9 -0.6 -0.6 1.8 -1.8 -0.6
Body mass index (BMI) 0.3 1.3 5.2 1.1 -0.3 -0.9 0.0 -2.3 -1.8 -0.4 -0.3 0.6 1.2
Impedance of leg (left) 1.8 8.6 22.5 0.4 -1.3 -3.6 0.0 -3.2 -2.4 -3.7 -4.3 -0.6 -4.7
Leg predicted mass (left) 0.4 2.4 11.0 -0.6 0.1 1.0 0.0 1.3 1.3 1.5 2.4 0.4 3.3
Trunk fat mass 0.5 2.3 9.0 0.6 -0.8 -1.9 0.0 -3.0 -2.2 -1.7 -1.1 0.5 0.2
Waist circumference 0.2 0.9 2.7 1.7 -0.5 -1.2 0.0 -1.0 -0.9 0.0 0.1 0.2 1.6
Number of incorrect matches in round 1.0 1.7 4.7 -0.0 -1.3 1.3 0.0 1.8 -0.6 1.2 0.1 2.2 2.1
Past tobacco smoking 0.7 1.3 6.4 0.5 1.1 -0.2 0.0 0.2 2.5 1.1 -1.4 -1.1 -1.0
Alcohol usually taken with meals 0.2 0.3 1.2 0.8 1.1 0.4 0.0 0.6 0.9 0.1 0.2 -0.0 0.1
Nervous feelings 0.5 0.9 6.3 -1.2 0.5 0.2 0.0 -0.5 -0.1 0.6 -0.2 2.5 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 6.1 -0.9 1.2 0.3 0.0 0.6 -0.2 2.5 -0.2 0.2 0.4
Hearing difficulty/problems with background noise 0.6 1.0 3.8 1.1 1.7 0.1 0.0 0.5 0.7 1.9 -0.6 0.4 0.9
Hair/balding pattern: Pattern 2 0.6 0.7 1.8 -1.3 -0.9 0.6 0.0 -0.2 -0.8 0.6 1.1 1.0 1.0
Had menopause 0.4 0.5 2.9 -0.3 -0.1 0.1 0.0 -1.0 -0.1 -0.4 0.5 1.7 0.5
Had other major operations 0.3 0.4 1.7 0.7 -0.3 -0.6 0.0 -0.2 -0.6 -0.2 -1.3 -0.7 -0.6
Forced vital capacity (FVC) 1.5 5.9 14.5 -3.1 -0.4 2.0 0.0 3.8 3.8 1.7 2.3 -3.0 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.3 -0.6 1.2 1.1 0.0 0.1 0.2 -0.4 1.1 1.1 1.1
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.1 -0.7 -1.1 0.3 0.0 -0.4 -1.1 -0.1 1.5 -0.9 -0.4
Qualifications: None of the above 0.2 0.3 1.6 -0.2 0.1 -1.3 0.0 0.1 -1.0 -0.6 0.0 0.6 0.1
Financial difficulties in last 2 years 0.5 0.7 4.3 0.5 0.8 -0.3 0.0 0.3 0.1 2.1 0.2 -0.7 0.9
Mouth/teeth dental problems 0.2 0.3 1.3 0.3 -0.8 1.1 0.0 -0.2 0.4 -0.7 0.3 0.3 0.0
Heart attack 1.0 1.3 5.2 2.3 1.3 -1.2 0.0 -1.5 -0.8 0.2 -1.0 1.0 -0.3
Allergy 0.4 0.9 3.4 -0.1 -0.4 0.4 0.0 1.8 1.3 0.7 0.9 1.1 1.2
Pain all over the body in last month 0.3 0.3 0.9 -0.7 -0.3 0.2 0.0 0.6 0.9 1.0 -0.3 -0.3 0.1
Diabetes (self-reported) 0.8 1.2 7.0 0.2 0.7 -0.8 0.0 -2.6 -0.9 0.3 -0.4 1.6 0.6
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.4 0.2 0.4 0.7 0.0 -0.2 0.2 0.3 -0.2 -0.5 -0.6
Medication: Ramipril 1.5 2.0 5.4 -1.2 0.3 1.9 0.0 0.7 0.4 1.1 2.3 1.5 2.3
Medication: Simvastatin 1.1 1.6 7.6 0.9 1.5 -0.6 0.0 -0.2 2.1 2.8 0.3 0.3 0.9
Fluid intelligence score 1.7 3.5 10.5 -0.8 1.1 2.5 0.0 2.1 1.4 1.6 2.3 1.4 3.2
Illnesses of siblings 1.1 1.6 4.8 1.0 -1.0 -1.4 0.0 -0.7 -0.5 -1.1 -1.8 -1.5 -2.2
Neuroticism score 0.3 0.7 5.1 -0.6 -2.3 -0.6 0.0 0.3 -0.5 0.3 0.2 0.5 0.3
Weight 0.1 0.6 2.8 0.2 -0.5 -0.8 0.0 -1.1 -0.5 -0.2 0.3 0.3 1.7
Impedance of arm (right) 0.5 2.2 8.1 -0.1 -0.4 -1.1 0.0 -1.7 -0.4 -1.6 -2.5 -0.2 -2.8
Arm fat percentage (right) 0.8 3.1 13.6 1.1 -0.7 -2.0 0.0 -3.7 -2.5 -1.5 -1.7 0.5 -0.2
Trunk fat-free mass 0.5 3.1 10.4 -0.9 -0.2 0.9 0.0 2.2 2.3 1.7 2.3 0.1 3.2
Hip circumference 0.1 0.4 2.1 0.4 -0.7 -0.2 0.0 -0.8 -0.4 -0.2 0.4 -0.1 1.4
Time employed in main current job 0.7 0.8 2.7 0.7 -0.7 0.6 0.0 1.3 1.6 0.2 0.3 0.9 0.9
Alcohol intake versus 10 years previously 0.5 0.7 4.7 1.0 2.2 -0.6 0.0 0.5 -0.1 0.1 -0.1 -0.0 0.8
Father’s age at death 0.7 0.9 4.6 -0.8 -1.6 -0.4 0.0 -0.6 -0.6 -2.1 0.4 0.3 -0.3
Worrier / anxious feelings 0.4 0.8 1.9 -1.4 -0.9 0.7 0.0 0.7 0.1 1.0 0.9 1.3 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.1 0.0 -0.5 -0.7 0.0 -0.1 -0.1 0.7 -0.2 -1.1 -0.5
Falls in the last year 0.8 1.1 4.6 -1.1 -0.8 0.8 0.0 -1.1 -0.1 0.2 0.9 2.1 1.5
Hair/balding pattern: Pattern 3 0.1 0.2 1.1 0.2 1.0 -0.1 0.0 0.6 0.5 -0.4 -0.3 0.2 -0.1
Number of live births 1.4 2.0 6.2 2.3 2.5 -1.3 0.0 -0.7 0.6 0.6 -2.3 0.6 -0.6
Forced expiratory volume in 1-second (FEV1) 1.5 4.9 17.9 -2.4 0.2 1.2 0.0 2.8 4.2 2.2 0.8 -3.2 -0.7
Pulse rate 1.8 3.1 6.6 -2.4 -1.3 -1.5 0.0 -2.4 -2.6 -1.9 1.3 -1.2 -1.4
Happiness 2.3 2.8 8.1 -1.3 -2.7 1.4 0.0 2.4 0.5 0.5 2.8 -0.2 1.7
Noisy workplace 1.0 1.2 2.8 1.5 0.0 -0.1 0.0 -0.2 1.4 1.5 -1.7 -1.1 -1.3
Qualifications: A levels/AS levels or equivalent 0.5 1.1 3.4 -1.3 -1.9 0.2 0.0 -1.3 -0.1 -1.5 1.2 0.6 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.7 0.6 -0.4 -0.5 0.0 -1.7 -0.8 0.1 -1.3 -0.1 -0.9
Mouth/teeth dental problems: Dentures 0.8 1.3 6.7 0.6 1.0 -1.2 0.0 -0.2 -1.1 0.1 -0.7 2.6 1.4
Asthma 1.1 2.1 6.4 0.6 0.3 -2.2 0.0 -2.5 -1.4 -0.8 -1.9 -0.6 -1.5
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.3 -0.1 0.8 0.4 0.0 -0.1 1.0 -0.1 0.6 -1.1 -0.7
Medication: Cholesterol lowering 2.2 3.3 13.5 1.4 1.7 1.2 0.0 1.2 2.3 3.7 -0.2 1.5 2.2
Depression (self-reported) 0.8 0.9 2.7 -0.6 -0.5 1.1 0.0 1.2 0.6 0.4 1.6 0.5 1.6
Medication: Lansoprazole 0.1 0.1 0.5 -0.0 -0.7 0.4 0.0 -0.2 -0.7 -0.1 -0.3 0.2 -0.1
Prospective memory result 1.5 1.8 4.4 1.7 -0.5 -1.7 0.0 -1.9 0.3 -0.3 -1.9 -0.8 -2.1
Lung cancer (father) 0.5 0.6 1.4 -0.9 -0.3 1.2 0.0 1.1 0.3 0.5 1.0 -1.2 -0.2
Illnesses of mother 0.6 0.8 2.1 0.5 -0.2 -1.3 0.0 -0.5 -1.3 -0.6 -1.5 1.2 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.7 22.8 -2.4 0.2 1.8 0.0 3.2 4.8 2.5 1.1 -2.8 -0.1
Pulse wave Arterial Stiffness index 0.5 0.6 4.0 -0.8 -0.6 -0.3 0.0 -0.4 -0.3 0.4 0.5 -2.0 -0.6
Impedance of arm (left) 0.4 1.8 8.7 -0.3 -0.3 -0.9 0.0 -1.2 -0.0 -1.2 -2.2 -0.9 -3.0
Arm fat mass (right) 0.4 1.6 7.7 0.9 -0.6 -1.4 0.0 -2.8 -1.7 -0.8 -1.1 0.5 0.7
Trunk predicted mass 0.5 3.1 10.2 -0.9 -0.1 0.9 0.0 2.3 2.4 1.8 2.3 -0.0 3.2
Standing height 0.2 1.7 6.1 -2.0 -0.7 0.1 0.0 1.9 2.5 0.2 1.0 -0.6 0.9
Length of working week for main job 1.0 1.1 3.9 -1.4 -0.9 0.9 0.0 0.5 -0.8 -0.6 1.4 -2.0 -0.6
Exposure to tobacco smoke at home 1.8 2.0 9.2 -2.0 -0.7 0.3 0.0 1.7 -0.1 0.6 3.0 0.7 1.7
Breastfed as a baby 0.5 0.6 2.6 -0.6 0.3 0.4 0.0 0.4 1.6 0.2 0.9 0.9 0.8
Tense / ‘highly strung’ 0.7 1.2 3.5 -0.1 -1.1 -1.6 0.0 -1.2 -1.6 -0.3 -0.6 1.9 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 4.5 -2.1 -1.9 0.0 0.0 -0.4 -1.7 -0.5 2.1 -0.1 0.1
Hair/balding pattern: Pattern 4 0.6 1.5 3.3 1.8 1.0 -0.3 0.0 1.2 1.2 1.5 -0.5 1.6 1.7
Birth weight of first child 0.0 0.1 0.2 0.5 0.3 -0.4 0.0 -0.1 -0.2 -0.4 -0.1 0.1 0.0
Peak expiratory flow (PEF) 0.8 1.8 10.0 -0.7 -0.8 -0.7 0.0 0.5 1.4 0.6 -0.5 -3.2 -1.8
Pulse wave reflection index 0.6 0.8 2.4 -0.8 -0.5 0.9 0.0 0.8 0.7 0.6 1.3 0.4 1.6
Ever highly irritable/argumentative for 2 days 0.3 0.4 2.2 0.4 -1.5 -0.1 0.0 -1.1 -0.3 -0.6 -0.2 0.3 -0.2
Loud music exposure frequency 1.0 1.1 6.2 2.5 0.1 -0.5 0.0 -0.3 0.3 0.4 -1.8 -0.2 -0.8
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.1 -0.8 0.3 0.8 0.0 -0.7 1.5 0.9 0.8 0.7 1.2
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 5.2 -0.5 1.0 -0.0 0.0 1.3 1.1 2.3 0.3 -0.6 0.4
Blood clot in the leg (DVT) 1.8 2.4 9.7 0.7 -3.0 -1.1 0.0 -1.4 -3.1 -1.0 0.6 -0.1 -0.5
Medication: Paracetamol 0.8 1.3 3.5 0.8 -0.5 -1.2 0.0 -1.5 -1.9 -1.4 -1.0 -0.3 -1.3
Headache pain in last month 0.2 0.4 1.2 -0.8 -0.4 -0.1 0.0 -0.9 -0.4 0.4 0.3 -1.1 -0.7
Medication for cholesterol, blood pressure or diabetes 2.5 4.2 12.4 -0.3 -1.3 -2.5 0.0 -1.8 -1.8 -3.5 -0.6 -2.2 -3.1
Glaucoma (self-reported) 0.3 0.4 1.5 -0.1 1.2 0.5 0.0 0.0 -0.7 -0.0 0.7 0.8 0.6
Gout (self-reported) 2.7 3.7 10.6 -1.0 -0.1 2.5 0.0 2.3 1.9 1.5 2.0 2.1 3.3
Hypothyroidism/myxoedema (self-reported) 0.6 1.3 9.0 3.0 0.6 0.6 0.0 0.4 0.1 1.0 -0.9 -0.9 -0.2
Medication: Amlodipine 1.9 2.7 5.7 0.5 2.0 2.1 0.0 1.6 1.5 2.2 0.3 1.5 2.4
Medication: Ventolin 100micrograms inhaler 1.6 2.1 5.7 0.6 -1.1 -2.4 0.0 -1.8 -1.9 -1.7 -1.3 -0.5 -1.5
Birth weight 0.3 0.6 2.0 0.7 0.7 0.6 0.0 1.1 1.4 0.8 -0.8 -0.5 0.5
Chronic bronchitis/emphysema (mother) 1.2 1.4 5.4 -0.7 -0.7 2.3 0.0 0.7 -0.1 1.0 1.1 1.1 1.9
High blood pressure (siblings) 0.9 1.3 3.6 -1.5 0.5 1.4 0.0 0.5 0.1 0.0 1.9 1.2 1.7
Forced vital capacity (FVC), Best measure 2.0 7.2 23.1 -2.5 -0.1 2.8 0.0 4.2 4.8 2.5 2.0 -2.6 0.6
Body fat percentage 1.3 5.3 17.3 1.1 -0.9 -2.8 0.0 -4.2 -3.5 -2.7 -2.1 0.6 -0.8
Leg fat percentage (right) 1.8 6.6 18.7 1.2 -1.4 -3.4 0.0 -4.3 -3.9 -3.2 -2.3 0.6 -1.1
Arm fat-free mass (right) 0.3 1.3 6.4 -0.6 -0.6 0.1 0.0 1.1 0.9 0.5 2.0 -0.1 2.5
Exposure to tobacco smoke outside home 0.2 0.3 0.6 -0.3 -0.7 0.3 0.0 0.8 -0.2 0.6 0.7 -0.5 0.7
Comparative body size at age 10 0.3 0.7 2.4 1.5 0.2 -1.2 0.0 -0.5 1.4 0.5 -0.6 -0.4 0.3
Number of full brothers 0.2 0.3 0.7 0.9 0.5 -0.8 0.0 -0.8 0.6 0.6 0.0 -0.0 0.0
Worry too long after embarrassment 1.0 1.7 9.7 -1.1 -3.1 -0.2 0.0 0.6 -1.0 -0.5 1.7 0.9 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.7 -0.0 -0.9 0.5 0.0 -0.1 -0.3 1.3 -1.0 0.9 0.7
Wheeze or whistling in the chest in last year 1.0 1.8 3.4 1.9 1.4 -1.2 0.0 -1.9 -1.8 0.4 -1.8 0.2 -0.9
Number of children fathered 0.6 0.7 2.0 0.2 1.4 -0.6 0.0 -0.6 1.0 0.0 -1.1 1.4 0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 6.1 2.3 -0.4 1.2 0.0 1.1 2.3 2.5 -0.3 0.3 0.8
Age at first live birth 0.2 0.4 1.5 -0.3 -0.6 1.2 0.0 -0.1 1.2 -0.7 -0.1 -0.1 -0.1
Pulse wave peak to peak time 0.6 0.8 4.4 0.9 0.8 0.3 0.0 0.7 0.5 -0.1 -0.6 2.1 0.8
Health satisfaction 2.0 2.6 8.0 -1.5 -1.6 -1.2 0.0 -1.2 -2.8 -1.6 1.0 -2.1 -1.6
Shortness of breath walking on level ground 0.7 0.8 4.2 2.0 0.4 0.1 0.0 -0.5 -0.5 0.9 -1.5 -0.2 -0.4
Qualifications: College or University degree 0.3 1.0 4.0 -0.1 0.5 1.2 0.0 1.1 2.0 1.3 0.5 -0.9 -0.3
Eye problems/disorders: None of the above 0.7 0.8 2.4 -1.0 -1.6 0.4 0.0 1.2 0.4 0.4 1.5 -0.0 1.0
Mouth/teeth dental problems: Loose teeth 2.2 2.6 5.6 1.8 2.2 -1.5 0.0 -1.9 0.6 0.1 -2.4 -1.0 -2.2
Emphysema/chronic bronchitis 0.9 1.0 6.9 0.1 -1.4 -0.4 0.0 -0.6 -2.6 -0.5 -0.2 -0.4 -0.5
Medication for pain relief, constipation, heartburn 0.3 0.5 1.5 -0.9 -1.1 0.5 0.0 0.7 1.2 -0.4 -0.0 -0.5 -0.4
Neck or shoulder pain in last month 0.3 0.4 1.1 0.7 -0.3 0.3 0.0 1.0 -0.5 1.0 0.4 -0.3 0.7
Medication: Blood pressure 3.4 6.0 20.0 -0.7 0.5 3.5 0.0 2.5 0.7 2.3 2.0 3.4 4.5
Angina (self-reported) 0.4 0.6 1.2 1.1 0.9 -0.7 0.0 -0.8 0.9 0.6 -0.2 1.0 0.4
Migraine (self-reported) 1.4 1.7 8.4 -2.9 -1.3 -0.6 0.0 -1.0 -0.6 -1.5 1.7 0.4 0.1
Medication: Ibuprofen 0.4 0.5 1.6 -0.1 1.0 0.1 0.0 0.3 1.3 -0.0 0.9 -1.0 -0.4
Medication: Allopurinol 1.4 1.9 6.0 -1.6 -0.7 1.5 0.0 0.7 0.5 0.7 2.0 1.6 2.4
Medication: Omeprazole 1.3 1.6 4.9 1.5 0.1 -1.7 0.0 -1.8 -0.9 1.0 -2.2 1.0 -0.1
Medication: Seretide 50 evohaler 0.6 0.7 2.7 0.3 -0.8 0.4 0.0 0.4 0.3 0.8 0.7 1.5 1.6
Mean time to correctly identify matches 1.6 3.0 14.7 2.2 1.6 0.2 0.0 0.4 -0.4 0.8 -1.8 3.8 2.0
Heart disease (mother) 0.4 0.5 1.6 -0.3 -1.1 -0.6 0.0 -1.0 0.1 -1.3 0.5 -0.2 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.5 1.2 0.8 -0.0 0.0 0.3 0.1 0.7 -0.6 -1.0 -0.7
Whole body fat mass 0.6 2.4 8.9 0.8 -0.7 -1.9 0.0 -3.0 -2.3 -1.6 -1.2 0.8 0.5
Leg fat mass (right) 0.8 3.0 10.1 1.0 -1.1 -2.1 0.0 -3.2 -2.7 -1.9 -1.1 1.0 0.5
Arm predicted mass (right) 0.3 1.4 7.3 -0.5 -0.2 0.2 0.0 1.1 0.8 0.5 1.9 0.3 2.7
Pulse rate, automated reading 2.9 9.3 20.9 -2.1 -2.6 -2.6 0.0 -4.6 -4.2 -4.1 0.4 -2.5 -3.6
Alcohol intake frequency. 0.4 0.9 2.2 1.4 1.5 -0.1 0.0 -0.2 0.1 1.0 -1.3 0.5 1.1
Comparative height size at age 10 0.2 1.2 6.3 -0.7 0.7 -0.4 0.0 1.6 2.5 0.6 0.2 0.1 1.4
Number of full sisters 0.7 0.9 2.1 1.4 1.3 -1.1 0.0 -0.3 -1.3 -1.0 -0.6 0.9 0.0
Suffer from ‘nerves’ 0.6 0.9 4.5 -0.7 -1.4 0.4 0.0 -0.7 -0.9 -0.1 -0.1 2.1 1.0
Overall health rating 0.2 0.4 2.1 0.6 -0.0 -0.3 0.0 -1.1 -1.4 0.2 0.1 -0.1 -0.0
Chest pain or discomfort 1.2 1.8 7.5 1.4 -0.2 -0.9 0.0 -1.6 -1.9 0.0 0.2 2.7 1.2
Had major operations 0.4 0.4 1.6 0.8 0.5 1.3 0.0 0.2 0.4 1.0 0.4 0.5 0.4
Age at last live birth 0.5 0.7 2.5 0.6 -0.6 -0.0 0.0 -1.3 0.7 -0.2 -1.6 1.3 0.3
Family relationship satisfaction 0.8 1.0 5.0 -2.2 -0.8 0.3 0.0 -0.4 1.0 -0.0 1.8 -0.1 0.5
Leg pain on walking 0.4 0.5 1.7 -0.8 -1.3 -0.0 0.0 0.8 -1.0 -0.0 0.2 -0.9 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 2.1 -0.9 -1.4 -0.6 0.0 -0.3 -0.5 -0.5 -0.4 -0.5 -0.2
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.1 -0.2 -1.1 -0.6 0.0 0.5 -0.3 -1.1 -0.0 0.4 0.5
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.1 -0.2 1.0 0.6 0.0 0.6 1.2 0.0 -0.6 1.4 0.6
Medication: Aspirin 1.4 1.8 6.2 1.5 1.4 0.2 0.0 0.5 0.6 2.5 -0.0 1.9 2.0
Supplements: Vitamin C 0.4 0.4 1.4 0.0 -0.8 0.8 0.0 0.6 0.2 1.0 -0.0 -1.2 -0.1
Knee pain experienced in last month 0.4 0.6 3.1 0.4 0.8 -0.3 0.0 0.7 0.2 1.0 -0.0 -1.8 -0.1
Hypertension (Self-reported) 1.2 3.3 11.6 -1.3 1.4 2.0 0.0 1.1 0.5 1.9 1.3 2.6 3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 3.7 1.9 -0.9 -1.6 0.0 -1.5 -1.4 0.5 -1.9 1.7 0.2
Illnesses of father: Heart disease 1.6 2.3 7.4 1.1 2.3 0.7 0.0 1.1 2.2 2.7 -0.4 0.9 1.0
Illnesses of siblings: Diabetes 0.5 0.6 2.8 0.1 1.7 -0.1 0.0 -0.3 -0.3 1.6 0.4 -0.2 0.4
Smoking status: Previous 0.3 0.4 1.8 -0.3 -0.1 0.3 0.0 -0.2 -1.3 -0.1 0.7 1.0 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 2.2 0.4 0.2 0.2 0.0 1.2 1.5 0.7 -0.5 -0.7 0.2
Whole body fat-free mass 0.5 2.7 10.8 -0.8 -0.1 0.9 0.0 1.8 1.8 1.6 2.4 0.2 3.3
Leg fat-free mass (right) 0.5 2.6 11.0 -0.3 0.4 1.2 0.0 1.5 1.6 1.9 2.2 0.3 3.3
Arm fat percentage (left) 0.6 2.6 11.9 1.1 -0.7 -1.9 0.0 -3.4 -2.3 -1.4 -1.3 0.2 -0.1
Average weekly red wine intake 0.3 0.4 1.9 -0.4 -0.0 -0.0 0.0 -1.4 -0.8 -0.7 -0.6 -0.2 -0.9
Handedness (chirality/laterality): Left-handed 0.4 0.4 2.3 0.3 -0.1 0.2 0.0 1.5 0.8 0.3 -0.3 -0.9 -0.5
Mood swings 0.4 0.8 3.4 0.2 -1.9 -0.7 0.0 -0.0 -0.5 -0.3 -1.3 -0.6 -1.1
Loneliness, isolation 1.0 1.3 3.8 0.2 -0.9 1.1 0.0 1.8 1.4 1.9 1.2 -0.4 0.9
Long-standing illness, disability or infirmity 1.0 1.6 4.3 1.8 1.7 -0.1 0.0 -1.1 -0.0 2.1 -1.0 1.2 1.3
Ever had bowel cancer screening 0.3 0.3 1.5 0.1 0.3 0.2 0.0 -0.7 -1.0 0.2 -0.2 1.2 0.5
Diabetes diagnosed by doctor 0.7 1.1 7.0 0.2 0.6 -1.1 0.0 -2.6 -0.3 0.6 -0.6 1.3 0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 4.9 2.0 0.5 -1.0 0.0 -2.2 -0.6 -0.1 -2.0 0.5 -0.4
Friendships satisfaction 1.4 1.8 5.2 -1.0 0.4 0.6 0.0 2.3 1.8 2.1 1.3 -1.3 0.3
Qualifications: nursing, teaching 1.3 2.0 5.7 1.0 1.3 2.4 0.0 2.4 1.8 1.7 -0.3 0.1 0.6
Commuting to job workplace: Walk 1.0 1.1 3.9 -0.3 1.8 -1.2 0.0 -0.2 0.8 2.0 -1.1 -0.0 -0.3
Eye problems/disorders: Cataract 0.8 0.9 3.3 0.9 1.0 -0.9 0.0 -1.5 -0.5 -0.2 -1.8 0.2 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.8 -0.6 0.5 1.4 0.0 2.0 1.2 1.6 0.8 -0.7 1.2
Medication for cholesterol 1.3 1.9 10.6 -0.7 -0.7 -0.6 0.0 -0.7 -2.4 -3.2 0.1 0.2 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 -0.3 -0.6 0.8 0.0 -0.2 -0.1 -0.3 0.7 0.9 0.8
Back pain experienced in last month 0.4 0.6 1.8 -1.3 1.3 -0.3 0.0 1.0 -0.2 0.1 1.1 0.1 0.8
Mineral and other dietary supplements 0.3 0.5 1.8 -0.3 1.3 -0.3 0.0 -0.1 -0.1 0.3 0.4 1.4 0.8
Breast cancer (self-reported) 0.3 0.4 1.4 -1.1 -0.3 -0.5 0.0 0.4 0.1 -0.5 1.2 0.2 0.4
Asthma (self-reported) 1.1 2.2 7.7 0.3 -0.1 -2.2 0.0 -2.8 -1.6 -1.1 -1.6 -0.6 -1.5
Osteoporosis (self-reported) 1.3 1.6 4.0 0.9 0.6 -1.5 0.0 -1.7 -2.0 -1.9 -0.5 0.1 -1.5
Osteoarthritis (self-reported) 0.1 0.1 0.8 0.1 -0.3 -0.1 0.0 0.0 -0.9 -0.3 0.3 -0.4 -0.2
Medication: Aspirin 1.3 1.7 5.2 2.0 1.4 -0.4 0.0 -0.1 0.4 2.3 -0.5 1.8 1.6
Medication: Gliclazide 0.2 0.3 1.1 0.2 0.6 -0.1 0.0 -0.3 -0.6 -0.4 0.4 0.5 1.1
Illnesses of father: None of the above (group 1) 1.7 2.1 7.9 -1.4 -2.8 0.1 0.0 -0.8 -1.4 -2.6 1.2 -0.3 -0.3
Smoking status: Current 0.3 0.5 1.1 1.0 -0.0 -0.1 0.0 0.9 -1.1 -0.0 1.0 -0.8 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 7.5 -1.1 0.3 1.3 0.0 1.2 2.7 1.1 0.5 -1.6 -0.2
Whole body water mass 0.5 2.6 10.4 -0.8 -0.2 0.8 0.0 1.7 1.7 1.4 2.4 0.1 3.2
Leg predicted mass (right) 0.4 2.4 10.3 -0.3 0.4 1.1 0.0 1.4 1.5 1.8 2.2 0.3 3.2
Arm fat mass (left) 0.3 1.3 6.2 0.9 -0.4 -1.2 0.0 -2.5 -1.5 -0.8 -0.6 0.5 0.9
Number of self-reported non-cancer illnesses 0.7 1.2 4.1 0.2 0.1 -0.5 0.0 -1.8 -2.0 0.8 0.0 1.6 1.3
Average weekly champagne plus white wine intake 0.6 0.8 3.0 0.1 -1.4 0.6 0.0 1.7 1.2 0.4 0.5 -0.2 0.4
Miserableness 0.4 0.7 3.0 0.1 -0.7 -0.6 0.0 1.7 -0.6 -1.0 0.8 0.5 0.6
Guilty feelings 0.1 0.2 1.1 0.4 -0.6 -0.2 0.0 -0.4 -0.0 1.0 -0.2 -0.3 0.2
Wears glasses or contact lenses 0.4 0.5 1.8 0.0 0.8 0.7 0.0 -1.4 -0.8 -1.0 0.2 0.6 -0.2
Ever taken oral contraceptive pill 2.1 2.4 10.5 -2.6 0.1 2.0 0.0 1.1 0.4 0.3 3.2 -0.5 0.8
Hearing aid user 0.2 0.2 0.8 0.2 0.9 -0.5 0.0 -0.5 0.2 -0.0 -0.3 0.2 -0.7
Mother’s age at death 1.5 1.9 5.7 -0.3 -0.8 -1.4 0.0 -1.8 -2.2 -2.4 -1.0 0.8 -1.2
Financial situation satisfaction 0.6 0.7 3.0 -0.7 -0.8 -1.1 0.0 -0.4 -0.5 0.0 0.2 -1.7 -1.1
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.5 -1.6 1.1 -0.3 0.0 1.6 -0.5 0.2 1.1 0.5 1.1
Commuting to job workplace: Public transport 0.3 0.3 1.0 -0.7 0.5 0.6 0.0 -0.5 0.1 0.4 0.5 1.0 0.7
Eye problems/disorders: Glaucoma 0.3 0.4 0.9 -0.8 0.7 0.2 0.0 0.1 -0.9 -0.9 0.9 0.6 0.2
Medication: Blood pressure 1.7 3.3 10.9 -0.1 2.0 2.1 0.0 1.3 2.5 3.3 1.0 0.6 2.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.6 -0.2 -0.3 -0.8 0.0 0.6 -1.3 -1.2 0.5 -0.7 -0.5
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.7 -0.2 -0.8 -0.5 0.0 -0.2 -0.4 -0.7 -0.7 -0.5 -0.8
High cholesterol (Self-reported) 1.3 2.3 9.5 1.9 1.2 -1.2 0.0 -0.2 2.0 3.1 -1.8 0.1 0.0
Medication: Bendroflumethiazide 2.1 3.3 10.2 -1.1 -0.5 2.1 0.0 1.9 0.6 1.4 2.1 2.4 3.2
Medication: Paracetamol 1.1 1.6 4.9 0.1 -0.3 -1.3 0.0 -2.0 -2.1 -2.2 -0.4 0.0 -1.1
Medication: Lisinopril 1.7 2.2 5.3 -0.7 0.5 2.1 0.0 2.3 2.0 1.5 1.6 0.2 1.8
Medication: Atorvastatin 1.6 2.0 7.3 2.7 1.7 -1.2 0.0 -0.8 1.0 1.7 -2.0 0.4 -0.2
Illnesses of father: High blood pressure 0.2 0.3 1.6 0.6 -0.1 -1.3 0.0 -0.3 -0.3 -0.3 -0.3 -0.4 -0.7
Alcohol drinker status: Never 0.5 0.6 2.1 -1.4 1.4 0.5 0.0 -0.3 0.8 0.7 -0.5 -0.5 -0.0
Ever smoked 0.6 1.0 3.5 0.2 -0.7 -0.4 0.0 -0.3 -1.9 -0.9 1.4 1.5 0.9
Basal metabolic rate 0.3 1.5 8.1 -0.5 -0.3 0.4 0.0 1.0 1.1 1.1 1.8 0.1 2.8
Leg fat percentage (left) 1.7 6.3 18.7 1.6 -1.0 -3.3 0.0 -4.3 -3.7 -2.9 -2.6 0.8 -1.0
Arm fat-free mass (left) 0.2 1.1 6.6 -0.7 -0.5 0.1 0.0 0.9 0.5 0.5 1.6 0.3 2.6
Number of operations (self-reported) 1.1 1.6 4.4 1.8 -0.9 -1.3 0.0 -2.1 -0.9 -0.5 -1.2 1.9 0.5
Average weekly beer plus cider intake 2.4 3.5 14.1 -2.2 -3.8 0.9 0.0 0.0 -1.3 -2.4 2.3 -1.4 -0.6
Irritability 0.6 0.9 3.7 1.1 -0.6 -1.8 0.0 -0.1 0.3 0.3 -1.9 -0.4 -0.6
Risk taking 0.4 0.5 1.4 0.6 -1.1 0.2 0.0 0.3 1.2 0.3 -1.1 -0.9 -0.0
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.9 -0.0 -0.0 1.2 0.0 0.5 -1.2 -0.6 -0.4 1.4 0.9
Fractured/broken bones in last 5 years 0.9 1.2 2.6 -1.1 -1.5 -0.7 0.0 -0.9 -1.3 -1.6 0.5 1.4 0.5
Age started oral contraceptive pill 0.6 0.8 3.5 -0.1 -0.9 0.7 0.0 0.2 1.6 0.4 -0.0 1.9 0.4
Diastolic blood pressure, automated reading 0.7 2.1 7.3 -0.5 1.3 1.6 0.0 1.2 1.7 2.7 1.3 0.3 1.6
Ever depressed for a whole week 1.4 1.7 6.0 -1.5 -2.5 1.4 0.0 0.0 -0.6 0.9 2.3 -0.1 0.6
Unable to work because of sickness or disability 0.4 0.5 1.8 -0.4 0.8 -0.7 0.0 -0.9 0.2 1.3 0.1 0.6 0.8
Commuting to job workplace: Cycle 1.7 2.0 5.5 -2.3 -1.6 2.3 0.0 0.3 1.3 1.1 1.5 -0.1 1.1
Myopia 0.4 0.6 2.3 1.2 0.9 0.3 0.0 0.3 1.5 1.1 0.3 -0.6 0.0
Vascular/heart problems diagnosed by doctor 1.0 2.8 9.1 0.4 -1.6 -1.5 0.0 -1.1 -1.0 -2.1 -1.1 -2.4 -3.0
Cholesterol lowering medication 2.4 3.5 8.2 2.2 2.4 -2.9 0.0 -2.1 1.2 1.8 -1.6 -1.2 -1.7
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 5.2 1.5 -0.1 -1.4 0.0 -2.2 -1.5 0.8 -2.3 0.7 -0.6
Pain experienced in last month 0.5 0.8 2.9 1.0 -0.4 -0.5 0.0 -1.0 0.8 -0.9 -1.7 1.0 -0.7
Supplements: Calcium 0.1 0.1 0.2 0.1 0.1 0.4 0.0 -0.3 0.1 0.3 0.1 -0.3 -0.4
Basal cell carcinoma (self-reported) 0.4 0.4 1.7 0.9 -0.1 0.1 0.0 -0.1 0.2 0.9 -1.3 0.8 0.5
Heart attack/myocardial infarction (self-reported) 0.9 1.2 4.1 2.0 1.4 -1.1 0.0 -1.3 -1.0 0.3 -0.7 1.1 -0.1
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 9.4 0.5 -2.9 -1.0 0.0 -1.5 -3.1 -0.9 0.6 -0.2 -0.5
Heart disease (siblings) 0.2 0.3 1.4 -0.5 0.8 0.0 0.0 0.2 0.7 0.1 1.2 0.1 0.5
Alcohol drinker status: Previous 1.3 1.5 5.0 1.9 1.0 -0.9 0.0 -1.8 -0.7 0.6 -2.2 -0.2 -0.8
Pack years of smoking 0.5 0.7 1.7 -0.7 -1.2 -1.3 0.0 -0.7 -1.3 -0.2 0.4 -0.7 -0.3
Impedance of whole body 1.0 5.2 18.1 -0.1 -1.0 -2.4 0.0 -2.2 -1.5 -2.9 -3.3 -1.0 -4.3
Leg fat mass (left) 0.8 3.1 10.5 1.1 -1.1 -2.1 0.0 -3.2 -2.7 -1.8 -1.0 1.1 0.6
Arm predicted mass (left) 0.2 1.0 5.7 -0.6 -0.7 0.0 0.0 0.8 0.5 0.3 1.7 0.1 2.4