TWAS hub - DNASE1L2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0632	0.0243	0.0006	-0.002	0.027	0.006	0.026	0.001	7e-01	6.1e-05	0.04300	6.7e-05	0.24000
2	TCGA	Testicular Germ Cell Tumors	0.2610	0.1310	0.0028	0.111	0.076	0.098	NA	0.090	1e-04	1.2e-03	0.00025	NA	0.00044

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Migraine (self-reported)	4.7	5.8	8.9	1.6	3.0
Comparative height size at age 10	4.7	25.9	39.1	-3.6	-6.2
Whole body fat-free mass	4.5	25.7	35.4	-4.0	-6.0
Whole body water mass	4.5	25.4	35.6	-3.9	-6.0
Basal metabolic rate	4.5	24.9	34.3	-3.9	-5.9
Trunk fat-free mass	4.4	25.3	37.5	-3.6	-6.1
Trunk predicted mass	4.4	24.9	37.5	-3.5	-6.1
Leg fat-free mass (right)	4.4	23.5	30.4	-4.1	-5.5
Leg fat-free mass (left)	4.3	22.9	29.5	-4.0	-5.4
Leg predicted mass (left)	4.3	22.8	29.4	-4.0	-5.4
Leg predicted mass (right)	4.3	22.9	29.4	-4.1	-5.4
Loud music exposure frequency	4.1	4.5	8.6	-2.9	-0.6
Arm fat-free mass (right)	4.1	21.2	30.6	-3.4	-5.5
Arm predicted mass (left)	4.0	20.5	28.3	-3.6	-5.3
Weight	3.9	18.9	25.0	-3.6	-5.0
Arm predicted mass (right)	3.9	19.9	27.8	-3.5	-5.3
Arm fat-free mass (left)	3.9	19.7	27.7	-3.4	-5.3
Supplements: Glucosamine	3.7	4.8	8.4	1.1	2.9
Falls in the last year	3.7	5.1	8.3	-1.3	-2.9
Height	3.6	69.4	104.0	-5.9	-10.2
LDL Cholesterol	3.3	5.2	7.0	-1.8	-2.7
Standing height	3.2	32.1	49.7	-3.8	-7.0
Triglycerides	3.1	5.0	6.1	-2.0	-2.5
Maternal smoking around birth	3.1	4.5	7.7	-1.2	-2.8
Hip circumference	3.1	13.5	17.9	-3.0	-4.2
Mean time to correctly identify matches	3.1	5.9	9.9	3.1	-1.4
Irritability	3.1	5.2	5.4	-2.3	-2.3
Average weekly fortified wine intake	3.0	3.5	6.2	2.5	0.9
Illnesses of father: Heart disease	3.0	4.2	6.5	2.5	1.4
Deep venous thrombosis (DVT) (self-reported)	3.0	3.9	4.6	2.2	-1.8
Ulcerative Colitis	2.9	4.2	7.6	0.8	2.8
Hand grip strength (left)	2.9	7.6	13.6	-3.7	-1.3
Serious illness, injury or assault to yourself	2.8	3.3	5.2	-2.3	-1.2
Qualifications: O levels/GCSEs or equivalent	2.8	4.4	5.0	2.0	2.2
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.2	8.6	-2.0	2.9
Sitting height	2.7	19.2	21.5	-4.6	-4.1
Medication: Simvastatin	2.7	4.0	4.6	-2.1	-1.8
Blood clot in the leg (DVT)	2.7	3.5	4.0	2.0	-1.7
Pain experienced in last month	2.6	4.4	8.7	0.0	-3.0
Depressed Affect (Nagel 2018)	2.4	5.0	5.7	-2.4	-2.1
Fed-up feelings	2.4	4.4	5.3	-1.9	-2.3
Breastfed as a baby	2.4	3.0	3.1	1.8	1.7
Commuting to job workplace: Car/motor vehicle	2.4	2.7	5.5	-0.1	2.3
Angina	2.3	3.0	4.6	-1.2	-2.1
Number of incorrect matches in round	2.3	3.8	7.2	2.7	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	3.0	3.7	-1.9	-1.5
Age at first live birth	2.3	4.1	4.1	2.0	2.0
Ever taken oral contraceptive pill	2.3	2.6	5.2	-2.3	0.1
Trunk fat mass	2.2	9.5	10.6	-2.9	-3.3
Reaction Time	2.1	4.0	7.6	2.7	-0.7
Neuroticism (2016)	2.1	3.0	5.2	-0.9	-2.3
Hypothyroidism (self reported)	2.1	4.8	6.7	2.6	-1.7
Hearing difficulty/problems: Yes	2.1	3.2	5.8	-2.4	0.7
Worry too long after embarrassment	2.1	3.5	5.1	2.3	1.4
Angina (self-reported)	2.1	2.7	4.0	-1.2	-2.0
Whole body fat mass	2.1	8.9	10.3	-2.7	-3.2
Hypertension (Self-reported)	2.1	5.7	11.3	3.4	0.4
Severe depression (siblings)	2.0	2.2	4.0	-2.0	-0.7
Hand grip strength (right)	2.0	5.5	9.2	-3.0	-1.4
Waist circumference	2.0	7.5	11.0	-2.0	-3.3
Commuting to job workplace: Walk	2.0	2.1	4.0	0.5	-2.0
Fasting Glucose	1.9	2.3	4.3	-2.1	0.4
Cardiovascular Disease	1.9	6.3	12.4	3.5	-0.4
Number of full brothers	1.9	2.4	3.5	1.9	1.1
Lung FVC	1.8	9.1	15.9	4.0	1.5
Arm fat mass (right)	1.8	7.5	7.9	-2.7	-2.8
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	4.7	2.2	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	6.3	2.5	1.1
Arm fat mass (left)	1.8	7.6	8.4	-2.6	-2.9
Rheumatoid Arthritis	1.7	2.3	3.3	1.8	-1.2
Systolic Blood Pressure	1.7	8.5	13.2	3.6	1.9
Diabetes (father)	1.7	2.1	3.8	-1.9	0.6
Hair/balding pattern: Pattern 2	1.7	2.1	4.0	0.5	-2.0
Mouth/teeth dental problems: Dentures	1.7	2.9	4.1	-2.0	-1.3
Medication: Cholesterol lowering	1.7	2.6	2.8	-1.6	-1.7
Age at last live birth	1.7	2.5	4.8	2.2	0.5
Bipolar Disorder (2018)	1.6	2.5	2.9	-1.5	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	6.3	-1.1	2.5
Handedness (chirality/laterality): Left-handed	1.6	2.0	3.4	-1.8	-0.7
Alcohol drinker status: Previous	1.6	1.8	2.9	0.8	-1.7
Impedance of leg (right)	1.5	7.5	9.3	3.0	2.4
Illnesses of siblings	1.5	2.1	2.3	-1.5	-1.4
Pulse wave reflection index	1.5	1.8	2.7	-1.0	1.6
Medication: Blood pressure	1.5	2.8	5.6	2.4	-0.1
Leg fat mass (left)	1.5	5.9	8.0	-1.9	-2.8
Neuroticism (Nagel 2018)	1.4	3.3	4.9	-1.3	-2.2
Age at First Birth	1.4	2.1	2.7	1.6	1.2
Average weekly spirits intake	1.4	1.7	3.0	-0.6	-1.7
High blood pressure	1.4	4.0	7.9	2.8	0.1
Impedance of leg (left)	1.4	7.0	9.4	3.1	2.1
Ever had bowel cancer screening	1.4	1.7	3.3	0.1	1.8
Heel T-Score	1.3	10.1	19.2	1.0	4.4
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.6	-0.8	1.6
Systolic blood pressure, automated reading	1.3	3.7	7.3	2.7	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.5	1.6	0.9
Birth weight	1.3	2.8	3.1	-1.8	-1.6
Chronic bronchitis/emphysema (mother)	1.3	1.5	1.6	-1.3	-1.2
Health satisfaction	1.3	1.7	2.4	1.5	1.0
Heart disease (mother)	1.3	1.6	1.9	-1.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	3.5	-1.4	-1.9
Mineral and other dietary supplements	1.3	1.7	3.3	0.4	-1.8
Miserableness	1.3	2.2	3.0	-1.7	-1.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	1.8	-1.3	1.1
Diastolic blood pressure, automated reading	1.3	4.0	6.7	2.6	1.1
Supplements: Calcium	1.3	1.5	2.4	-1.6	-0.7
Pack years of smoking	1.3	1.9	2.3	-1.3	-1.5
Pain all over the body in last month	1.2	1.3	2.1	-1.5	0.7
Gout (self-reported)	1.2	1.7	2.6	-0.9	-1.6
Leg fat mass (right)	1.2	4.7	6.0	-1.9	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	1.6	-1.3	-1.1
Guilty feelings	1.2	1.8	3.5	0.2	1.9
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.8	-0.1	1.7
Bipolar Disorder or Schizophrenia	1.1	2.7	4.4	-1.0	2.1
Lung FEV1/FVC ratio	1.1	5.7	11.1	0.5	-3.3
Diabetes (mother)	1.1	1.4	1.6	-1.1	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	5.0	1.3	-2.2
Eye problems/disorders: None of the above	1.1	1.3	2.3	0.5	-1.5
Had major operations	1.1	1.3	1.8	-1.3	-0.9
Hearing aid user	1.1	1.2	1.7	0.9	-1.3
Impedance of whole body	1.1	5.8	7.0	2.1	2.6
Mean Putamen Volume	1.0	1.1	1.8	-0.6	1.4
Pack years adult smoking proportion	1.0	1.5	1.8	-1.1	-1.3
Medication: Levothyroxine sodium	1.0	1.6	2.1	1.0	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.9	-1.7	-0.4
Hair/balding pattern: Pattern 4	1.0	2.3	4.1	-0.8	2.0
High blood pressure (siblings)	1.0	1.5	2.3	1.5	0.8
Medication: Omeprazole	1.0	1.2	2.2	0.3	1.5
Supplements: Vitamin C	1.0	1.1	2.3	1.5	-0.1
Illnesses of siblings: Diabetes	1.0	1.2	2.3	0.2	1.5
Qualifications: nursing, teaching	1.0	1.6	3.1	1.7	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	1.9	1.2	1.4
Worry (Nagel 2018)	0.9	1.9	3.6	-0.4	-1.9
Prostate Cancer	0.9	1.2	2.3	-1.5	0.4
Lupus	0.9	1.4	1.8	1.0	-1.4
Schizophrenia (2014)	0.9	2.0	2.8	-1.7	1.1
Smoking Status	0.9	2.1	2.2	-1.4	-1.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.5	0.7	1.2
Trunk fat percentage	0.9	3.6	4.2	-2.1	-1.7
Current tobacco smoking	0.9	1.5	1.9	-1.1	-1.4
Stomach or abdominal pain in last month	0.9	1.1	1.9	1.4	0.4
Body mass index (BMI)	0.9	4.0	4.1	-2.0	-2.0
Time employed in main current job	0.9	1.1	1.9	-1.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	1.9	-0.4	-1.4
Osteoporosis (self-reported)	0.9	1.2	2.3	-0.0	1.5
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.6	-1.3	-0.8
Ovarian Cancer	0.8	1.1	1.1	-1.0	-1.0
BMI	0.8	4.8	8.4	-1.1	-2.9
Townsend deprivation index at recruitment	0.8	1.2	2.0	1.4	-0.6
Birth weight of first child	0.8	1.4	1.7	-1.3	-1.1
Number of children fathered	0.8	0.9	1.9	-0.1	1.4
Medication: Seretide 50 evohaler	0.8	0.9	1.2	0.8	1.1
Loneliness, isolation	0.8	1.1	1.4	-1.2	-0.9
Back pain experienced in last month	0.8	1.2	1.6	-1.2	1.0
Fractured/broken bones in last 5 years	0.8	1.0	1.8	-0.4	-1.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.5	-1.2	-0.7
Heart disease (siblings)	0.8	1.0	1.2	1.1	-0.9
Ulcerative Colitis (UC)	0.7	1.3	2.1	0.8	1.4
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.3	-1.5	-0.5
Ever had hysterectomy (womb removed)	0.7	0.7	1.2	-1.1	0.6
Heart attack	0.7	0.9	1.4	-1.2	-0.7
Impedance of arm (right)	0.7	3.3	3.5	1.8	1.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	3.4	1.1	-1.9
Noisy workplace	0.7	0.8	1.2	-1.1	-0.7
Lung cancer (father)	0.7	0.8	1.1	0.7	-1.1
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	-1.2	-0.4
Medication: Amlodipine	0.7	1.0	1.0	1.0	-1.0
Emphysema/chronic bronchitis	0.7	0.8	1.5	1.2	0.2
Medication: Gliclazide	0.7	0.8	1.1	-1.1	-0.7
Smoking status: Current	0.7	1.1	1.2	-1.0	-1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.7	-0.3	1.3
High cholesterol (Self-reported)	0.7	1.2	2.1	-0.6	-1.5
Medication: Lisinopril	0.7	0.9	1.3	1.2	0.6
Illnesses of father: High blood pressure	0.7	0.9	1.8	1.3	-0.2
Alcohol drinker status: Never	0.7	0.8	1.1	-1.0	0.8
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.0	-2.0	0.2
Primary Biliary Cirrhosis	0.6	0.9	1.7	-1.3	0.0
Neuroticism	0.6	1.5	3.0	-0.2	-1.7
Medication for hormone replacement therapy	0.6	0.7	1.3	0.0	1.1
Chronic bronchitis/emphysema (father)	0.6	0.6	1.2	0.2	1.1
Past tobacco smoking	0.6	1.1	1.8	1.3	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.1	-0.9	-1.0
Hearing difficulty/problems with background noise	0.6	0.9	1.1	-1.1	0.9
Qualifications: None of the above	0.6	1.3	1.8	-1.3	-0.9
Medication: Ramipril	0.6	0.7	1.2	-1.1	-0.5
Fluid intelligence score	0.6	1.2	2.3	-0.0	1.5
Father’s age at death	0.6	0.8	1.5	-0.4	1.2
Worrier / anxious feelings	0.6	1.1	1.5	1.2	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	0.9	1.0	-0.7
Illnesses of mother	0.6	0.8	1.5	1.2	0.2
Headache pain in last month	0.6	1.1	2.1	0.0	1.5
Forced vital capacity (FVC), Best measure	0.6	2.4	3.1	1.3	-1.8
Body fat percentage	0.6	2.5	2.9	-1.7	-1.4
Average weekly red wine intake	0.6	0.9	1.2	-1.1	0.8
Wears glasses or contact lenses	0.6	0.7	1.2	-0.3	1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	-0.4	1.2
Medication: Atorvastatin	0.6	0.8	0.9	0.8	0.9
Risk taking	0.6	0.8	1.4	-1.2	-0.5
Unable to work because of sickness or disability	0.6	0.8	1.6	-0.3	-1.2
Schizophrenia (2018)	0.5	1.0	2.0	-0.1	1.4
Relative age voice broke	0.5	0.8	0.8	0.9	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.9	1.0	-0.5
Nervous feelings	0.5	0.9	0.9	-1.0	1.0
Forced vital capacity (FVC)	0.5	1.9	2.2	1.3	-1.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.3	-0.0	-1.1
Arm fat percentage (right)	0.5	1.9	2.5	-1.6	-1.2
Pulse rate	0.5	0.9	1.7	-0.1	-1.3
Happiness	0.5	0.6	1.3	1.1	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.1	0.5	1.4
Medication: Lansoprazole	0.5	0.6	0.9	-0.9	0.6
Impedance of arm (left)	0.5	2.5	3.3	1.3	1.8
Pulse wave peak to peak time	0.5	0.6	1.3	1.1	-0.0
Smoking status: Previous	0.5	0.8	1.1	-1.1	-0.6
Arm fat percentage (left)	0.5	2.0	2.7	-1.6	-1.2
Mood swings	0.5	0.9	1.5	-0.5	-1.2
Friendships satisfaction	0.5	0.7	0.7	0.8	0.8
Financial situation satisfaction	0.5	0.6	1.1	1.1	0.3
Commuting to job workplace: Public transport	0.5	0.6	0.6	-0.8	-0.7
Myopia	0.5	0.7	1.3	1.1	-0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	-0.1	-1.0
Alzheimer’s Disease (in father)	0.4	0.5	0.9	-1.0	0.1
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.3	-0.8	1.2
HDL Cholesterol	0.4	0.7	1.3	0.4	1.1
Blood Platelet Count	0.4	4.1	4.8	1.8	-2.2
Blood Red Count	0.4	4.0	6.2	1.4	2.5
Tanning	0.4	5.1	8.9	-3.0	1.2
Number of treatments/medications taken	0.4	0.8	1.5	0.2	1.2
Sensitivity / hurt feelings	0.4	0.6	1.3	-0.1	-1.1
Vitamin and mineral supplements	0.4	0.5	1.1	-1.0	-0.1
Medication: Metformin	0.4	0.5	0.6	-0.7	0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.6	0.8	0.4
Qualifications: CSEs or equivalent	0.4	0.5	0.9	0.4	-1.0
Financial difficulties in last 2 years	0.4	0.6	0.8	0.9	-0.6
Exposure to tobacco smoke outside home	0.4	0.5	0.9	0.3	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	-1.0	-0.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	1.0	0.2
Neck or shoulder pain in last month	0.4	0.5	0.6	0.7	0.8
Suffer from ‘nerves’	0.4	0.6	1.0	-1.0	0.4
Diabetes diagnosed by doctor	0.4	0.6	1.2	-1.1	-0.1
Medication: Aspirin	0.4	0.6	1.2	-1.1	0.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.0	-0.1	1.4
Blood Eosinophil Count	0.3	2.6	4.7	0.7	-2.2
Relative age of first facial hair	0.3	0.7	0.8	-0.7	-0.9
Supplements: Zinc	0.3	0.4	0.7	0.0	0.9
Had other major operations	0.3	0.3	0.6	0.8	-0.3
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	-0.5	0.7
Prospective memory result	0.3	0.4	0.5	0.7	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.4	0.6	0.5
Medication: Paracetamol	0.3	0.4	0.8	-0.1	-0.9
Comparative body size at age 10	0.3	0.9	1.3	0.7	-1.1
Shortness of breath walking on level ground	0.3	0.3	0.3	0.6	-0.6
Medication: Blood pressure	0.3	0.5	0.8	-0.3	0.9
Medication: Ibuprofen	0.3	0.4	0.7	0.8	-0.2
Medication: Allopurinol	0.3	0.3	0.6	-0.8	-0.2
Leg pain on walking	0.3	0.4	0.8	0.9	-0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	0.2	0.8
Medication: Aspirin	0.3	0.3	0.7	-0.8	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.3	0.6	-0.5
Eye problems/disorders: Cataract	0.3	0.3	0.7	0.1	-0.8
Medication for cholesterol	0.3	0.5	0.6	-0.8	-0.5
Number of self-reported non-cancer illnesses	0.3	0.6	0.8	0.6	-0.9
Medication: Bendroflumethiazide	0.3	0.5	1.0	1.0	-0.0
Number of operations (self-reported)	0.3	0.5	0.7	-0.8	-0.5
Irritable Bowel Disease (IBD)	0.2	0.4	0.4	0.7	0.6
Crohns Disease (2012)	0.2	0.4	0.6	0.8	-0.3
Blood White Count	0.2	1.6	2.1	1.4	-1.1
Chronotype (morning person)	0.2	0.5	1.0	-0.1	1.0
Hair Pigment	0.2	5.5	9.8	3.1	1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	0.3	-0.5
Medication: Co-codamol	0.2	0.2	0.4	-0.2	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.3	-0.5	-0.5
Age when periods started (menarche)	0.2	0.5	0.7	-0.6	0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.2	0.6
Multivitamins +/- minerals	0.2	0.2	0.4	-0.1	0.6
Medication: Atenolol	0.2	0.3	0.5	0.2	-0.7
Had menopause	0.2	0.2	0.4	-0.1	0.6
Mouth/teeth dental problems	0.2	0.3	0.5	0.7	-0.2
Allergy	0.2	0.3	0.5	-0.7	0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.5	0.7	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.2	0.4	0.3	-0.6
Length of working week for main job	0.2	0.2	0.3	0.5	-0.5
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.6	0.1
Peak expiratory flow (PEF)	0.2	0.4	0.7	-0.8	-0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.0	0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.5	0.7	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.3	0.6	0.4
Wheeze or whistling in the chest in last year	0.2	0.4	0.5	-0.5	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.2	-0.4	0.4
Alcohol intake frequency.	0.2	0.6	0.9	-0.9	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	0.1	0.7
Age started oral contraceptive pill	0.2	0.2	0.4	-0.3	-0.6
Cholesterol lowering medication	0.2	0.4	0.5	-0.5	-0.7
Depression (Nagel 2018)	0.1	0.1	0.2	-0.1	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.2	0.4
Breast Cancer	0.1	0.3	0.6	0.1	0.7
Body Mass Index (BMI) (2010)	0.1	0.2	0.2	0.3	-0.4
Allergy or Eczema	0.1	0.2	0.2	-0.5	0.3
Taking other prescription medications	0.1	0.2	0.4	-0.1	0.7
Alcohol usually taken with meals	0.1	0.2	0.4	-0.6	0.3
Diabetes (self-reported)	0.1	0.2	0.2	-0.5	0.3
Neuroticism score	0.1	0.3	0.5	-0.3	-0.7
Number of live births	0.1	0.2	0.3	0.3	0.5
Tense / ‘highly strung’	0.1	0.2	0.3	-0.2	-0.5
Glaucoma (self-reported)	0.1	0.1	0.3	0.5	-0.0
Qualifications: College or University degree	0.1	0.4	0.5	0.6	0.7
Medication for pain relief, constipation, heartburn	0.1	0.2	0.2	0.4	0.4
Pulse rate, automated reading	0.1	0.2	0.2	0.4	-0.4
Number of full sisters	0.1	0.1	0.2	-0.2	-0.5
Overall health rating	0.1	0.2	0.4	-0.7	-0.2
Family relationship satisfaction	0.1	0.1	0.1	0.2	0.3
Knee pain experienced in last month	0.1	0.2	0.4	0.1	-0.6
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.2	-0.4	0.4
Breast cancer (self-reported)	0.1	0.2	0.3	0.1	-0.6
Average weekly champagne plus white wine intake	0.1	0.2	0.2	-0.5	-0.3
Leg fat percentage (left)	0.1	0.4	0.7	-0.2	-0.8
Commuting to job workplace: Cycle	0.1	0.2	0.2	0.4	-0.4
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.6	0.2
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.2	0.0
Crohns Disease (2017)	0.0	0.1	0.2	0.2	-0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.1	-0.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.1	-0.2
Waist Hip Ratio (WHR)	0.0	0.1	0.3	-0.5	-0.0
Respiratory disease	0.0	0.1	0.1	-0.3	0.3
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	0.1	0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.4	0.2
High blood pressure (mother)	0.0	0.0	0.1	0.2	-0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	-0.1	-0.2
Asthma	0.0	0.0	0.1	-0.2	-0.2
Depression (self-reported)	0.0	0.1	0.1	-0.3	0.1
Leg fat percentage (right)	0.0	0.1	0.1	-0.2	-0.4
Chest pain or discomfort	0.0	0.1	0.1	-0.1	0.4
Asthma (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Osteoarthritis (self-reported)	0.0	0.0	0.0	-0.0	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.3	0.2
Mother’s age at death	0.0	0.0	0.1	0.1	0.2
Medication: Paracetamol	0.0	0.0	0.0	-0.2	-0.1
Ever smoked	0.0	0.1	0.1	-0.0	0.4
Average weekly beer plus cider intake	0.0	0.0	0.1	-0.0	0.3
Ever depressed for a whole week	0.0	0.1	0.1	-0.3	-0.1

Hub : Genes

DNASE1L2

Models

Trait associations