Hub : Genes

DUSP5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0187	0.0101	2.1e-02	0.000	0.002	0.004	0.003	-0.001	0.32000	8.3e-02	2.1e-02	2.4e-02	5.5e-01
2	YFS	Blood	0.0458	0.0125	2.2e-07	0.009	0.028	0.026	0.026	0.019	0.00036	1.7e-09	6.7e-09	3.7e-09	3.9e-07
3	TCGA	Breast Invasive Carcinoma	0.1361	0.0567	7.6e-06	0.013	0.034	0.033	NA	0.016	0.00076	1.1e-07	2.1e-07	NA	2.6e-04
4	TCGA	Lung Adenocarcinoma	0.0178	0.0111	6.8e-03	0.027	0.015	0.024	NA	0.021	0.00036	6.4e-03	7.1e-04	NA	1.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.9	3.0	5.8	2.4	1.6	-1.6	1.0
Bipolar Disorder or Schizophrenia	0.5	1.3	2.5	1.1	0.6	-1.1	1.6
Depressed Affect (Nagel 2018)	0.5	1.0	3.2	0.7	0.7	0.2	-1.8
Depression (Nagel 2018)	0.1	0.2	0.5	-0.7	0.4	0.3	0.1
Intelligence (Savage-Jansen 2018)	0.9	2.8	4.7	0.3	2.0	-1.6	-2.2
Neuroticism (Nagel 2018)	0.1	0.3	0.5	0.5	-0.7	0.3	-0.3
Schizophrenia (2018)	0.3	0.5	1.6	-0.6	-0.5	-0.1	1.2
Schizophrenia vs Biploar Disorder	1.3	1.7	5.5	-2.4	0.3	1.0	0.2
Worry (Nagel 2018)	0.6	1.3	2.5	0.4	-1.6	0.5	1.5
Alzheimer’s Disease (in mother)	1.0	1.2	2.9	-1.7	0.6	1.2	-0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.3	0.7	0.0	0.6
Alzheimer’s Disease (including proxy)	1.0	1.4	2.5	-1.0	1.4	1.6	0.6
Crohns Disease (2017)	3.7	8.1	13.4	-0.3	-3.7	2.7	3.4
Irritable Bowel Disease (IBD)	3.3	7.9	11.7	-1.2	-3.0	3.1	3.4
Ulcerative Colitis (UC)	2.3	4.3	5.3	-1.6	-2.1	2.3	2.2
Major Depression (MDD)	0.1	0.1	0.3	0.3	-0.5	0.1	0.4
Reaction Time	0.2	0.4	0.9	0.9	0.1	0.7	-0.5
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.7	1.1	0.8	-0.9	-1.9
Breast Cancer	1.1	2.6	7.0	-0.6	-1.6	2.6	0.7
Ovarian Cancer	0.5	0.6	1.9	0.2	0.7	1.4	0.4
Prostate Cancer	0.4	0.6	1.7	-0.2	-1.3	-0.1	0.8
Age at First Birth	0.6	0.8	1.8	0.1	-1.2	-0.1	1.3
Bipolar Disorder (2011)	0.4	0.4	1.6	0.3	1.3	-0.2	-0.1
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	-1.1	-0.7	-0.3	-0.5
Coronary Artery Disease (CAD)	1.8	2.2	7.9	-0.5	-0.7	-2.8	-0.2
Crohns Disease (2012)	2.3	3.6	8.0	0.3	-2.4	0.9	2.8
Mean Putamen Volume	0.1	0.1	0.2	0.0	0.0	-0.1	0.5
Fasting Glucose	1.2	1.4	3.2	1.4	-1.8	-0.6	0.3
HbA1C	1.6	1.7	4.8	1.4	0.2	-2.2	-0.5
HDL Cholesterol	0.2	0.4	1.0	0.6	0.4	0.2	1.0
LDL Cholesterol	0.9	1.4	3.1	-0.9	1.8	0.0	-1.3
Lupus	0.9	1.4	3.3	0.7	1.1	-1.8	-0.8
Neuroticism (2016)	0.4	0.5	1.2	0.4	-0.4	1.1	0.8
Primary Biliary Cirrhosis	0.8	1.1	2.5	1.0	-1.6	-0.0	1.0
Rheumatoid Arthritis	2.4	3.3	7.9	-0.8	-2.8	1.6	1.5
Schizophrenia (2014)	0.2	0.5	1.3	-0.9	0.4	0.1	1.1
Triglycerides	0.6	1.0	1.9	-1.4	0.8	-0.6	-1.0
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.9	0.7	-1.4	-0.4	-0.3
Ulcerative Colitis	1.6	2.3	3.5	-1.0	-1.3	1.7	1.9
Blood Eosinophil Count	0.7	5.0	19.9	-4.5	0.3	0.2	0.3
Blood Platelet Count	0.2	2.4	8.5	-2.9	-0.1	-0.4	-0.9
Blood Red Count	0.2	1.6	2.2	1.5	1.3	-1.4	-0.7
Blood White Count	1.0	7.6	22.8	-4.8	-1.0	-1.7	-1.9
Heel T-Score	2.8	22.6	53.7	5.2	-3.0	-0.3	7.3
BMI	0.2	1.3	2.2	-0.7	-1.5	-1.2	-1.0
Height	0.1	1.1	2.7	1.6	-0.1	0.1	1.4
Waist Hip Ratio (WHR)	0.7	3.2	6.6	-2.2	0.9	0.6	-2.6
Systolic Blood Pressure	0.4	2.1	3.7	0.9	1.5	1.3	1.9
Smoking Status	1.1	2.7	5.6	0.6	2.4	1.9	-1.2
Allergy or Eczema	0.9	2.3	8.0	2.8	0.0	-0.6	1.0
Cardiovascular Disease	0.3	1.0	1.5	-1.1	0.7	0.8	1.2
Hypothyroidism (self reported)	0.5	1.1	2.6	-0.8	-0.6	-1.0	1.6
Respiratory disease	0.4	1.0	3.3	0.5	-0.3	0.2	1.8
Type 2 Diabetes (T2D) (2018)	2.3	4.3	6.6	-0.4	-2.4	2.1	2.6
Lung FEV1/FVC ratio	0.5	2.5	5.1	-2.3	-0.8	-1.6	-1.4
Lung FVC	0.5	2.6	9.5	-0.2	1.0	-0.2	-3.1
Neuroticism	0.2	0.4	1.2	-0.1	-0.6	1.1	-0.3
Chronotype (morning person)	1.1	2.6	6.4	-0.2	-1.9	0.4	2.5
Hair Pigment	0.1	3.7	10.8	-1.6	-1.1	0.5	3.3
Tanning	0.0	0.4	1.3	0.6	-0.0	1.1	0.3
Hand grip strength (left)	1.1	2.8	3.3	-1.7	1.7	-1.5	-1.8
Number of treatments/medications taken	0.4	0.8	2.6	0.4	0.3	0.6	1.6
Average weekly spirits intake	1.0	1.3	2.6	0.8	1.6	-0.4	-1.3
Sensitivity / hurt feelings	0.5	0.9	2.4	-0.3	-1.6	-1.1	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	-0.7	0.3	0.8	0.5
Hearing difficulty/problems: Yes	0.7	1.1	1.8	-1.2	-1.1	-1.4	0.1
Relative age of first facial hair	0.3	0.7	1.5	0.5	0.4	0.9	1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	0.1	-0.9	0.0	1.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.3	0.2	-1.0	1.1	0.8
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	1.1	-0.4	0.0	-1.2
Systolic blood pressure, automated reading	0.2	0.5	1.9	0.1	-0.1	1.4	0.5
Eye problems/disorders: Diabetes related eye disease	3.0	3.3	6.3	-0.8	-2.5	1.9	1.6
Angina	0.5	0.6	1.1	-1.1	-0.9	-0.7	0.0
Medication for hormone replacement therapy	1.8	2.1	5.8	-2.4	-0.1	-0.1	1.6
Vitamin and mineral supplements	1.2	1.6	3.6	0.5	1.4	-1.9	0.8
Supplements: Zinc	0.8	0.8	1.4	0.5	0.8	-1.0	-1.2
Medication: Co-codamol	0.0	0.1	0.2	0.1	0.2	0.1	0.4
Medication: Metformin	1.3	1.8	3.1	-0.1	-1.0	1.8	1.8
Diabetes (father)	2.0	2.4	4.6	-1.7	-2.1	1.2	0.9
Diabetes (mother)	1.9	2.4	8.2	-0.9	-2.9	0.7	0.6
Severe depression (siblings)	2.9	3.3	4.8	-2.2	1.9	-0.9	-2.0
Pack years adult smoking proportion	0.5	0.7	1.3	0.3	-0.3	1.1	-1.2
Impedance of leg (right)	1.1	5.2	13.5	2.1	3.7	1.5	0.9
Leg fat-free mass (left)	0.2	0.9	1.5	-0.7	-1.1	-1.2	-0.5
Trunk fat percentage	0.2	0.8	3.0	1.7	0.4	0.0	-0.3
Hand grip strength (right)	0.6	1.7	4.6	-0.7	1.2	-2.1	-0.8
Townsend deprivation index at recruitment	0.3	0.4	0.9	-0.1	0.9	-0.1	-0.8
Current tobacco smoking	2.9	4.7	6.8	2.6	2.4	-0.0	-2.5
Average weekly fortified wine intake	0.0	0.0	0.1	0.4	0.2	0.0	0.1
Maternal smoking around birth	1.0	1.5	4.2	-0.6	2.0	-0.6	-0.9
Fed-up feelings	0.3	0.6	2.1	1.5	0.4	-0.3	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.8	0.7	1.3	-0.3	0.5
Relative age voice broke	0.9	1.4	4.0	0.1	-0.5	2.0	1.1
Taking other prescription medications	0.3	0.4	1.4	-1.2	0.1	0.5	-0.2
Age when periods started (menarche)	0.3	0.8	3.0	0.5	0.1	-1.7	-0.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.0	1.1	-0.1	-0.0	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	3.8	8.6	22.0	2.2	-2.6	0.8	4.7
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.6	0.3	-0.2	-1.9	-0.5
Qualifications: CSEs or equivalent	1.7	2.2	4.8	-1.7	-0.6	1.0	2.2
Serious illness, injury or assault to yourself	2.4	3.0	9.6	0.9	3.1	-0.6	-1.0
High blood pressure	0.5	1.3	2.3	-1.3	-0.6	0.9	1.5
Hayfever, allergic rhinitis or eczema	1.3	2.8	8.6	2.9	0.5	-1.0	1.2
Multivitamins +/- minerals	0.9	1.2	2.4	-0.2	-1.0	1.6	-1.1
Stomach or abdominal pain in last month	0.8	1.0	1.9	-1.3	-0.5	-0.1	-1.4
Supplements: Glucosamine	0.9	1.2	3.0	0.9	0.2	1.7	-0.9
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	10.2	0.7	0.6	-3.2	-1.1
Medication: Atenolol	0.8	0.9	2.2	-0.4	-0.8	-1.5	0.9
Medication: Levothyroxine sodium	0.8	1.4	3.5	-0.7	-1.9	-1.1	-0.4
Sitting height	0.2	1.4	2.2	0.3	-1.0	-1.5	1.5
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	-1.1	-1.2	-0.1	-0.3
High blood pressure (mother)	1.9	2.6	5.4	0.9	-2.0	-0.3	2.3
Body mass index (BMI)	0.3	1.4	2.9	-0.7	-1.2	-0.8	-1.7
Impedance of leg (left)	0.9	4.5	8.3	2.6	2.9	1.2	1.2
Leg predicted mass (left)	0.2	0.9	1.6	-0.7	-1.1	-1.3	-0.4
Trunk fat mass	0.1	0.5	1.6	1.3	-0.1	-0.4	-0.4
Waist circumference	0.4	1.6	5.9	-0.5	-0.0	-0.4	-2.4
Number of incorrect matches in round	0.8	1.4	2.0	1.4	-0.7	1.2	1.2
Past tobacco smoking	1.2	2.2	4.1	2.0	-0.6	-2.0	0.4
Alcohol usually taken with meals	0.5	0.8	1.4	-0.2	-0.9	1.0	1.2
Nervous feelings	0.7	1.3	2.5	1.1	-1.6	0.2	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.3	-0.0	1.5	0.6	-0.6
Hearing difficulty/problems with background noise	0.5	0.7	2.8	0.1	-0.1	-1.7	-0.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	0.5	0.3	1.1	0.2
Had menopause	0.5	0.6	1.5	0.6	-0.1	1.2	0.7
Had other major operations	1.5	1.9	4.4	-2.1	-0.6	0.9	1.4
Forced vital capacity (FVC)	0.3	1.1	1.6	0.0	1.3	-1.2	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	2.6	5.9	15.6	1.8	-1.8	1.4	4.0
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	4.5	1.6	1.0	2.1	0.3
Qualifications: None of the above	0.5	1.1	2.4	0.7	-1.2	0.3	-1.6
Financial difficulties in last 2 years	0.1	0.2	0.7	-0.3	0.8	0.1	0.1
Mouth/teeth dental problems	0.1	0.2	0.4	0.6	-0.2	-0.4	0.5
Heart attack	1.3	1.7	4.3	-0.6	0.5	-2.1	-1.4
Allergy	1.2	2.7	7.3	-2.7	-0.2	0.7	-1.7
Pain all over the body in last month	0.5	0.5	1.3	-0.1	0.6	-0.7	1.2
Diabetes (self-reported)	2.5	3.9	6.2	-0.1	-2.0	2.5	2.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.1	1.4	0.7	-0.1	0.8
Medication: Ramipril	1.6	2.1	4.5	0.3	-1.8	2.1	0.5
Medication: Simvastatin	0.2	0.2	0.3	0.6	-0.5	-0.4	-0.4
Fluid intelligence score	1.1	2.4	4.9	0.7	1.9	-0.5	-2.2
Illnesses of siblings	0.6	0.9	2.5	0.2	0.1	-1.6	-0.9
Neuroticism score	0.2	0.4	0.7	0.8	-0.1	0.8	-0.3
Weight	0.1	0.6	0.9	-0.1	-0.8	-0.9	-0.9
Impedance of arm (right)	0.6	2.6	4.8	1.4	2.2	0.9	1.7
Arm fat percentage (right)	0.1	0.2	0.9	-0.0	0.1	-0.2	-1.0
Trunk fat-free mass	0.2	1.1	2.4	-0.8	-1.2	-1.6	-0.3
Hip circumference	0.1	0.4	1.0	0.7	-0.1	-0.2	-1.0
Time employed in main current job	1.1	1.2	2.1	-1.5	-1.4	-0.4	0.7
Alcohol intake versus 10 years previously	0.2	0.2	0.6	-0.5	0.1	0.8	0.3
Father’s age at death	0.9	1.1	2.1	1.4	0.4	-1.2	-0.9
Worrier / anxious feelings	1.8	3.4	8.3	-0.3	-2.9	1.6	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.5	0.2	1.0	-1.2	-1.0
Falls in the last year	0.5	0.7	2.5	-0.3	-1.6	0.1	0.1
Hair/balding pattern: Pattern 3	1.1	1.6	3.8	-0.1	-0.6	-1.9	-1.5
Number of live births	1.6	2.2	6.2	-0.3	-2.5	1.1	1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	3.4	-0.9	1.4	-1.8	-1.7
Pulse rate	0.3	0.5	0.7	-0.8	0.8	-0.7	-0.2
Happiness	0.1	0.2	0.4	0.5	0.1	-0.6	-0.1
Noisy workplace	1.0	1.2	2.2	-0.2	1.5	-0.7	-1.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.3	-0.2	0.2	-1.5	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.6	-0.1	-1.9	1.3	1.1
Mouth/teeth dental problems: Dentures	0.5	0.9	1.5	0.3	-1.1	0.9	1.2
Asthma	0.7	1.4	4.7	0.8	-0.6	-0.3	2.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.8	1.3	0.9	0.6	-1.0
Medication: Cholesterol lowering	0.4	0.6	1.8	0.8	1.3	-0.2	-0.3
Depression (self-reported)	0.3	0.3	1.0	0.5	0.2	1.0	0.2
Medication: Lansoprazole	1.4	1.6	3.1	-1.6	-1.7	-0.4	-0.9
Prospective memory result	2.8	3.4	6.5	-0.8	-1.5	2.1	2.5
Lung cancer (father)	2.5	2.9	9.5	-1.0	1.0	3.1	-0.1
Illnesses of mother	1.8	2.3	6.3	0.2	2.5	-0.3	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.9	-0.8	1.0	-1.1	-1.4
Pulse wave Arterial Stiffness index	0.6	0.7	1.0	-1.0	-0.9	-0.6	0.9
Impedance of arm (left)	0.8	3.8	5.2	2.0	2.3	1.5	1.9
Arm fat mass (right)	0.1	0.4	1.2	0.2	-0.3	-0.7	-1.1
Trunk predicted mass	0.2	1.1	2.0	-0.8	-1.3	-1.4	-0.2
Standing height	0.1	1.2	2.2	1.5	0.4	-0.8	1.3
Length of working week for main job	0.9	1.0	1.9	-1.4	-1.4	0.5	0.1
Exposure to tobacco smoke at home	1.7	1.9	6.3	-0.4	0.6	-0.8	-2.5
Breastfed as a baby	0.1	0.2	0.6	0.1	0.8	0.2	-0.3
Tense / ‘highly strung’	0.5	0.8	2.4	1.6	0.8	-0.1	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.3	2.1	0.5	-0.8	0.7
Hair/balding pattern: Pattern 4	0.6	1.4	4.2	-0.2	-0.2	1.1	2.0
Birth weight of first child	0.4	0.8	2.3	0.6	0.2	1.5	0.6
Peak expiratory flow (PEF)	0.9	2.0	2.8	-1.5	1.7	-1.2	-1.3
Pulse wave reflection index	0.3	0.4	0.7	0.8	-0.1	0.7	0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	1.0	-0.7	-0.9	-0.5
Loud music exposure frequency	0.6	0.6	1.2	-1.1	0.7	0.9	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.0	-0.5	0.8	-0.6	-1.0
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	4.2	-1.2	0.9	-0.2	-2.0
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.8	-0.6	-0.1	0.4
Medication: Paracetamol	1.1	1.8	3.5	1.3	1.9	1.1	0.9
Headache pain in last month	0.3	0.5	1.1	-0.8	0.5	-1.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.5	-0.5	0.6	0.2
Glaucoma (self-reported)	0.9	1.1	2.0	0.4	1.4	-1.4	0.5
Gout (self-reported)	0.6	0.9	1.9	-0.4	1.4	-0.0	1.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.2	-0.7	-1.5	-0.9	0.8
Medication: Amlodipine	1.6	2.3	4.6	-1.6	-1.1	2.1	0.9
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.3	-0.1	1.8	-0.5	0.4
Birth weight	0.3	0.8	2.0	-0.7	-0.7	0.2	1.4
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.6	-0.8	0.4	0.8	0.5
High blood pressure (siblings)	0.5	0.7	2.1	-0.1	0.8	1.4	-0.5
Forced vital capacity (FVC), Best measure	0.2	0.8	1.3	-0.2	1.1	-0.9	-1.1
Body fat percentage	0.2	0.6	1.3	1.1	0.5	-0.2	-0.9
Leg fat percentage (right)	0.3	1.1	3.3	0.4	0.7	0.5	-1.8
Arm fat-free mass (right)	0.2	1.2	3.0	-0.0	-1.4	-1.7	0.1
Exposure to tobacco smoke outside home	0.5	0.7	2.3	-0.1	0.1	-0.6	-1.5
Comparative body size at age 10	0.7	1.8	6.1	-1.1	-2.5	-0.2	-0.2
Number of full brothers	0.8	1.0	2.9	1.7	1.0	-0.0	-0.1
Worry too long after embarrassment	0.4	0.7	0.8	0.8	-0.9	0.6	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.5	1.2	1.1	-0.3	-0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	-0.4	-0.0	-0.2	0.6
Number of children fathered	1.3	1.4	2.5	-0.8	-1.6	1.6	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.4	-0.1	-0.8	0.1	1.9
Age at first live birth	0.8	1.5	3.7	-1.1	0.9	-0.5	-1.9
Pulse wave peak to peak time	0.6	0.7	0.9	1.0	0.9	0.4	-0.9
Health satisfaction	0.4	0.5	1.6	-1.3	0.4	-0.3	-0.4
Shortness of breath walking on level ground	0.2	0.2	0.5	0.1	-0.7	0.3	0.5
Qualifications: College or University degree	0.3	1.0	2.7	-1.0	1.6	-0.0	-0.6
Eye problems/disorders: None of the above	2.7	3.1	6.4	2.5	2.2	0.5	-1.0
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.1	-0.2	0.3	0.2	-0.2
Emphysema/chronic bronchitis	1.3	1.4	2.5	-0.2	1.2	1.6	-1.3
Medication for pain relief, constipation, heartburn	0.7	1.1	2.6	-1.6	-1.3	-0.3	-0.0
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.8	-0.3	0.3	-0.6
Medication: Blood pressure	0.2	0.4	0.8	-0.9	-0.2	-0.7	0.4
Angina (self-reported)	0.5	0.7	1.4	-1.2	-0.8	-0.8	-0.1
Migraine (self-reported)	0.7	0.9	3.2	-0.4	1.8	-0.3	-0.5
Medication: Ibuprofen	1.3	1.5	2.7	1.6	1.4	0.0	-1.2
Medication: Allopurinol	0.4	0.6	0.8	-0.7	0.8	-0.9	0.5
Medication: Omeprazole	1.3	1.6	6.0	0.2	0.1	2.5	0.5
Medication: Seretide 50 evohaler	0.5	0.6	2.3	-0.1	-0.3	-0.2	1.5
Mean time to correctly identify matches	0.1	0.1	0.3	0.4	-0.1	0.3	-0.5
Heart disease (mother)	0.4	0.5	1.8	-1.3	-0.2	0.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.6	0.7	1.1	0.2	1.3
Whole body fat mass	0.1	0.3	0.5	0.7	0.0	-0.4	-0.7
Leg fat mass (right)	0.2	0.6	2.2	0.3	0.2	-0.2	-1.5
Arm predicted mass (right)	0.2	0.8	2.0	-0.0	-1.0	-1.4	-0.3
Pulse rate, automated reading	0.3	1.0	2.3	-0.1	1.3	-0.4	-1.5
Alcohol intake frequency.	0.5	1.1	4.1	0.0	-2.0	0.4	-0.2
Comparative height size at age 10	0.4	2.4	5.1	2.3	-0.5	-1.1	1.8
Number of full sisters	0.7	0.8	2.3	-0.5	1.5	0.7	0.4
Suffer from ‘nerves’	0.9	1.3	4.9	-0.0	-0.6	-0.3	2.2
Overall health rating	0.3	0.7	1.5	0.6	-0.6	-0.7	1.2
Chest pain or discomfort	1.8	2.6	9.8	-0.7	-0.3	-3.1	-0.1
Had major operations	0.8	0.9	3.1	-0.8	-0.2	-1.8	-0.1
Age at last live birth	0.4	0.6	1.5	-0.6	-0.2	-0.7	-1.2
Family relationship satisfaction	0.3	0.4	0.9	0.2	0.7	-0.2	-0.9
Leg pain on walking	0.3	0.3	1.0	0.5	-1.0	-0.1	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	0.4	-0.2	-1.4	-0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.3	-0.4	-0.4	-0.9	-1.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.6	0.2	-0.7	0.0	0.8
Medication: Aspirin	0.4	0.6	1.2	1.1	-0.1	-0.5	0.8
Supplements: Vitamin C	1.1	1.3	2.9	-1.7	-1.5	0.1	0.1
Knee pain experienced in last month	0.8	1.3	4.5	-0.0	-0.4	-0.7	-2.1
Hypertension (Self-reported)	0.4	1.0	1.7	-1.3	-0.3	0.9	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	7.6	-1.8	-1.8	2.8	0.3
Illnesses of father: Heart disease	0.8	1.1	2.8	0.2	-1.2	0.2	1.7
Illnesses of siblings: Diabetes	0.8	1.0	2.4	0.1	1.6	1.3	-0.1
Smoking status: Previous	2.0	3.0	6.0	-2.4	-0.3	2.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.5	0.4	1.2	-0.0	0.4
Whole body fat-free mass	0.2	1.2	2.5	-0.7	-1.3	-1.6	-0.3
Leg fat-free mass (right)	0.2	1.2	2.7	-0.6	-1.6	-1.4	-0.2
Arm fat percentage (left)	0.0	0.2	0.7	0.2	0.0	-0.0	-0.8
Average weekly red wine intake	1.6	2.3	6.2	0.6	-1.4	0.9	2.5
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.6	-1.1	1.6	0.5	-0.8
Mood swings	0.4	0.7	1.5	-0.6	0.9	1.2	-0.4
Loneliness, isolation	1.1	1.5	3.0	1.7	0.6	0.2	-1.6
Long-standing illness, disability or infirmity	0.3	0.5	0.9	-0.4	-0.2	-0.9	1.0
Ever had bowel cancer screening	1.0	1.2	2.2	-0.8	1.2	-0.8	-1.5
Diabetes diagnosed by doctor	2.5	4.1	6.9	0.1	-2.4	2.0	2.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.2	-1.1	0.3	-0.4	-0.9
Friendships satisfaction	0.2	0.3	0.7	-0.2	0.0	-0.7	-0.8
Qualifications: nursing, teaching	0.7	1.0	2.0	0.8	1.0	-1.4	0.6
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.5	-0.1	0.4	0.6
Eye problems/disorders: Cataract	2.7	3.1	5.4	-2.3	-2.3	0.0	1.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	-0.1	0.3	0.3	0.4
Medication for cholesterol	1.6	2.4	3.4	1.1	1.5	-1.7	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.5	1.1	-0.2	-1.2	1.2
Back pain experienced in last month	0.2	0.3	0.9	0.9	-0.3	-0.3	0.2
Mineral and other dietary supplements	0.5	0.6	1.8	0.4	0.3	-1.4	0.6
Breast cancer (self-reported)	1.5	1.8	6.0	0.5	2.5	0.3	-0.9
Asthma (self-reported)	0.6	1.1	3.4	0.7	-0.7	-0.3	1.8
Osteoporosis (self-reported)	0.3	0.3	0.7	0.4	-0.3	0.8	0.5
Osteoarthritis (self-reported)	0.8	1.1	2.5	1.6	-1.3	0.2	-0.2
Medication: Aspirin	0.6	0.8	1.8	1.0	0.2	-0.5	1.3
Medication: Gliclazide	0.7	0.8	1.8	-0.0	-0.8	1.4	0.8
Illnesses of father: None of the above (group 1)	1.2	1.5	2.8	-0.9	1.5	-0.2	-1.7
Smoking status: Current	3.0	4.7	6.8	2.3	2.6	-0.1	-2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	2.4	-1.1	-0.3	-1.4	-1.5
Whole body water mass	0.2	1.2	2.6	-0.7	-1.2	-1.6	-0.4
Leg predicted mass (right)	0.2	1.2	2.4	-0.6	-1.5	-1.4	-0.2
Arm fat mass (left)	0.1	0.4	0.9	0.3	-0.3	-0.6	-0.9
Number of self-reported non-cancer illnesses	0.2	0.3	1.2	-0.1	0.4	-0.2	1.1
Average weekly champagne plus white wine intake	0.1	0.1	0.3	-0.5	0.3	0.1	0.2
Miserableness	0.8	1.4	2.7	1.6	1.0	-0.2	-1.4
Guilty feelings	1.1	1.6	3.2	-0.2	0.8	1.8	1.6
Wears glasses or contact lenses	1.2	1.4	3.3	-1.4	-1.8	0.2	-0.2
Ever taken oral contraceptive pill	1.2	1.3	2.5	-1.6	1.3	-0.1	-1.0
Hearing aid user	0.9	1.1	3.8	0.3	-0.6	0.1	1.9
Mother’s age at death	1.1	1.3	3.5	1.9	0.7	-1.1	-0.5
Financial situation satisfaction	0.6	0.8	2.2	1.5	0.7	-0.4	0.4
Tinnitus: Yes, now most or all of the time	1.3	1.6	6.2	-2.5	-0.1	-0.1	-0.1
Commuting to job workplace: Public transport	1.2	1.4	2.6	-1.4	0.1	1.6	1.0
Eye problems/disorders: Glaucoma	1.0	1.2	2.2	0.7	1.4	-1.5	0.7
Medication: Blood pressure	1.0	1.9	5.1	-0.7	-1.0	2.3	1.0
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	0.7	-0.4	-0.2	0.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.0	-0.5	-1.1	1.4	0.4
High cholesterol (Self-reported)	0.1	0.1	0.2	0.2	0.2	0.5	-0.3
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.3	-0.1	0.8	0.1
Medication: Paracetamol	1.1	1.7	3.4	1.3	1.9	1.2	0.5
Medication: Lisinopril	0.3	0.4	0.5	-0.6	0.7	-0.7	-0.5
Medication: Atorvastatin	0.4	0.5	1.5	0.3	1.2	-0.2	-0.5
Illnesses of father: High blood pressure	0.5	0.6	1.7	-0.6	0.2	1.3	-0.5
Alcohol drinker status: Never	0.7	0.9	1.3	-0.9	-0.9	-0.7	1.2
Ever smoked	2.0	3.6	5.6	-2.4	0.7	2.2	-1.8
Basal metabolic rate	0.2	0.9	2.0	-0.5	-1.1	-1.4	-0.5
Leg fat percentage (left)	0.2	0.7	2.4	0.5	-0.1	0.3	-1.6
Arm fat-free mass (left)	0.3	1.4	3.3	-0.5	-1.2	-1.8	-0.7
Number of operations (self-reported)	1.1	1.6	4.0	-1.0	-2.0	-0.7	0.9
Average weekly beer plus cider intake	0.3	0.4	0.6	0.6	-0.7	-0.7	0.5
Irritability	0.4	0.7	1.0	0.8	0.9	0.4	-1.0
Risk taking	0.6	0.8	3.0	0.1	1.7	-0.4	0.3
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.7	-1.6	0.5	0.3	-1.0
Fractured/broken bones in last 5 years	1.3	1.6	6.0	0.3	0.6	-0.3	-2.5
Age started oral contraceptive pill	0.8	1.0	2.2	0.2	-0.4	1.3	1.5
Diastolic blood pressure, automated reading	0.3	0.8	2.1	-0.5	0.9	1.5	0.1
Ever depressed for a whole week	0.3	0.3	0.8	0.3	0.9	0.5	-0.6
Unable to work because of sickness or disability	0.8	1.0	1.4	-1.2	-0.8	1.0	1.1
Commuting to job workplace: Cycle	0.4	0.4	1.5	0.5	0.2	-0.0	-1.2
Myopia	1.0	1.5	5.2	2.3	0.5	0.5	0.5
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.4	1.5	0.3	-0.6	-1.0
Cholesterol lowering medication	1.1	1.6	5.2	0.1	-2.3	0.1	1.1
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	3.0	0.5	-0.6	1.7	0.5
Pain experienced in last month	0.3	0.4	1.0	-0.2	0.5	0.7	1.0
Supplements: Calcium	0.5	0.5	1.2	0.0	0.4	0.9	-1.1
Basal cell carcinoma (self-reported)	1.0	1.2	2.9	-1.7	-0.4	1.2	0.4
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.9	-0.8	0.3	-2.0	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	1.0	-0.2	0.1	0.2
Heart disease (siblings)	0.6	0.7	2.4	0.4	0.4	-0.0	1.5
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.9	0.1	0.7	-0.7
Pack years of smoking	0.8	1.2	2.6	-0.2	-0.4	1.6	-1.5
Impedance of whole body	0.9	4.8	6.9	2.5	2.6	1.3	2.0
Leg fat mass (left)	0.1	0.5	1.8	0.3	-0.4	-0.3	-1.4
Arm predicted mass (left)	0.2	1.1	2.7	-0.3	-1.2	-1.6	-0.4