Hub : Genes

DYNC1I1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1180	0.0460	7.4e-03	-0.002	0.018	-0.001	0.022	-0.002	8.6e-01	2.5e-03	5.4e-01	9.4e-04	8.3e-01
2	GTEx	Brain Cerebellar Hemisphere	0.3470	0.0930	6.5e-05	0.149	NA	0.195	NA	0.008	1.2e-04	NA	1.0e-05	NA	1.9e-01
3	GTEx	Brain Cerebellum	0.2790	0.0870	2.2e-04	0.028	NA	0.259	NA	0.010	5.0e-02	NA	2.9e-08	NA	1.6e-01
4	GTEx	Heart Atrial Appendage	0.2510	0.0780	1.0e-03	0.059	NA	0.033	NA	0.053	1.3e-03	NA	1.3e-02	NA	2.2e-03
5	GTEx	Muscle Skeletal	0.1201	0.0320	2.1e-06	0.122	NA	0.083	NA	0.100	6.0e-12	NA	1.6e-08	NA	4.8e-10
6	METSIM	Adipose	0.0709	0.0221	1.5e-05	0.019	0.032	0.028	0.031	0.024	6.2e-04	1.1e-05	3.7e-05	1.6e-05	1.2e-04
7	ROSMAP	Brain Pre-frontal Cortex	0.0622	0.0242	3.8e-03	0.024	0.017	0.008	0.020	0.010	3.6e-04	2.4e-03	2.8e-02	1.2e-03	1.8e-02
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0957	0.0347	5.6e-04	0.061	0.026	0.041	NA	0.043	2.3e-07	5.3e-04	1.7e-05	NA	1.3e-05
9	TCGA	Pancreatic Adenocarcinoma	0.1130	0.0530	7.9e-03	0.012	0.015	-0.005	NA	-0.007	9.7e-02	7.7e-02	6.3e-01	NA	9.1e-01
10	TCGA	Prostate Adenocarcinoma	0.0621	0.0273	1.3e-03	0.037	0.022	0.015	NA	0.029	8.5e-05	2.0e-03	1.0e-02	NA	4.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.5	0.7	2.0	0.1	-0.2	1.3	-0.8	-1.2	-0.7	0.6	-0.5	-0.6	-1.4
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	-1.0	-0.5	1.2	0.1	-0.4	0.4	-0.5	-0.5	-0.7	-1.0
Depressed Affect (Nagel 2018)	0.8	1.7	9.0	0.3	2.3	1.1	0.2	0.4	0.3	0.4	0.3	3.0	0.5
Depression (Nagel 2018)	0.9	1.4	4.2	0.7	2.1	1.7	-1.4	-0.6	0.9	0.4	-0.9	1.5	0.2
Intelligence (Savage-Jansen 2018)	0.6	1.8	6.6	1.8	-1.0	0.1	-1.7	-1.9	-2.6	0.0	-0.3	-0.7	-0.7
Neuroticism (Nagel 2018)	1.1	2.5	11.9	0.3	2.6	1.7	1.0	0.7	0.4	-0.9	0.5	3.5	0.9
Schizophrenia (2018)	0.3	0.6	1.9	-1.4	-0.5	0.5	0.8	0.5	1.0	-1.1	-0.2	-0.5	-0.2
Schizophrenia vs Biploar Disorder	2.8	3.7	11.1	-2.0	0.8	1.3	3.3	2.9	2.0	-0.9	-0.1	1.6	2.0
Worry (Nagel 2018)	2.1	4.5	16.8	0.7	3.2	2.4	1.5	1.3	1.1	-0.8	1.2	4.1	2.1
Alzheimer’s Disease (in mother)	0.3	0.4	2.0	0.4	0.2	-0.2	-0.3	-0.7	-0.1	0.6	0.1	-0.8	-1.4
Alzheimer’s Disease (in father)	0.7	0.7	1.7	0.2	1.3	0.7	0.8	0.8	0.6	-1.1	-0.6	1.2	0.8
Alzheimer’s Disease (including proxy)	0.2	0.3	1.2	0.7	0.6	0.6	0.5	0.1	-0.0	-1.1	-0.7	-0.1	-0.5
Crohns Disease (2017)	0.2	0.4	2.7	0.3	0.5	-0.0	-0.4	0.3	0.4	-1.7	0.1	0.6	0.3
Irritable Bowel Disease (IBD)	0.3	0.6	2.0	-0.8	0.6	0.5	0.7	1.0	0.7	-0.4	-0.4	1.4	0.8
Ulcerative Colitis (UC)	0.4	0.8	2.5	-1.6	0.4	0.6	0.8	0.7	0.5	1.0	-0.6	1.3	0.6
Major Depression (MDD)	1.1	1.3	3.1	1.8	1.4	0.6	-1.6	-0.8	0.7	1.2	0.3	1.0	1.1
Reaction Time	0.7	1.3	3.8	0.0	-0.7	-1.2	0.8	1.1	-1.0	-1.9	-1.9	0.1	-1.0
Verbal and Numeric Reasoning (VNR)	0.8	1.9	5.6	2.4	0.2	-0.2	-1.7	-2.0	-2.3	1.1	-0.5	0.2	-0.2
Breast Cancer	0.5	1.2	5.5	0.8	-0.0	-0.0	-0.6	-0.2	-2.3	-1.3	-1.6	-0.4	-0.9
Ovarian Cancer	0.2	0.3	1.3	0.9	0.2	-0.4	0.0	0.5	-0.4	-1.1	-0.3	0.0	0.2
Prostate Cancer	1.2	1.7	3.2	-0.3	1.8	0.8	1.7	1.6	1.4	-0.0	-1.0	1.7	1.1
Age at First Birth	0.2	0.2	1.1	-1.0	-0.6	0.1	0.3	-0.3	0.2	0.0	-0.1	-0.6	-0.6
Bipolar Disorder (2011)	1.1	1.1	4.0	0.8	1.6	2.0	-0.2	-0.4	1.2	-0.8	0.4	0.7	1.1
Body Mass Index (BMI) (2010)	1.6	2.1	5.3	1.5	-0.2	-0.1	-2.3	-1.8	-1.4	1.0	-2.0	-0.6	-1.8
Coronary Artery Disease (CAD)	2.8	3.3	6.6	-1.2	2.4	2.6	1.9	1.9	1.0	-0.6	-0.7	2.5	2.0
Crohns Disease (2012)	0.3	0.4	2.0	-0.8	0.7	0.7	0.2	0.6	0.3	-1.4	-0.1	0.7	0.1
Mean Putamen Volume	0.2	0.2	0.8	0.1	0.1	0.7	0.6	0.5	0.1	-0.1	0.3	0.0	0.9
Fasting Glucose	1.2	1.5	6.8	0.4	-0.7	-0.5	-1.5	-1.9	0.0	0.9	2.6	-0.6	0.7
HbA1C	1.3	1.4	3.8	0.2	-1.6	-1.3	-1.4	-1.4	0.3	-1.2	0.5	-1.9	0.4
HDL Cholesterol	0.4	0.7	1.9	0.7	-0.1	1.0	0.2	0.2	-1.4	-0.5	1.1	-0.1	1.2
LDL Cholesterol	0.3	0.5	1.9	-1.4	0.5	0.3	0.9	0.2	0.8	-0.9	-0.3	0.6	0.5
Lupus	0.4	0.6	2.8	-0.8	-0.0	0.4	-0.1	-0.1	1.1	0.6	1.0	-0.1	1.7
Neuroticism (2016)	0.8	1.1	3.7	0.6	1.6	1.6	0.5	0.2	-0.9	0.3	-0.8	1.9	0.4
Primary Biliary Cirrhosis	0.9	1.3	5.7	0.4	1.3	0.7	-0.9	-0.1	-0.4	1.3	-2.4	1.4	-0.0
Rheumatoid Arthritis	0.3	0.4	1.8	-1.3	0.5	0.2	-0.3	-0.5	0.1	0.3	0.3	0.3	0.9
Schizophrenia (2014)	0.6	1.2	3.7	-1.4	0.7	1.9	1.3	0.9	1.6	-0.5	0.4	0.0	0.9
Triglycerides	0.2	0.4	1.4	-0.5	0.6	-0.5	-0.6	-1.2	-0.0	-0.0	-0.7	0.1	-0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.5	-0.5	0.7	0.6	0.5	0.4	-0.7	-0.2	-0.4	0.7	-0.3
Ulcerative Colitis	1.3	1.9	4.4	-1.0	0.8	1.9	1.7	1.4	0.5	0.0	0.2	2.0	2.1
Blood Eosinophil Count	0.1	1.1	5.2	-1.2	-2.3	-0.3	0.4	0.2	-0.5	0.1	-1.3	-0.5	-1.3
Blood Platelet Count	0.2	2.6	10.6	-1.2	-0.2	1.0	3.3	2.7	0.1	-1.7	0.8	1.5	0.5
Blood Red Count	0.1	1.2	2.7	1.6	-1.1	-0.5	-1.3	-1.2	-0.7	0.5	-1.4	-0.6	-1.2
Blood White Count	0.1	1.1	6.2	0.2	-0.5	0.5	1.9	2.5	0.4	-0.8	-0.2	0.3	-0.4
Heel T-Score	1.4	11.2	36.8	-2.3	5.1	2.6	-3.6	-2.0	2.4	6.1	-1.1	2.6	-2.5
BMI	0.3	1.9	4.9	0.9	0.7	1.1	-2.2	-1.9	-0.5	2.0	-0.9	-0.3	-1.7
Height	0.3	5.0	14.9	0.0	-0.5	-0.1	-1.8	-1.2	3.8	-0.8	3.9	-1.6	3.6
Waist Hip Ratio (WHR)	0.2	1.0	4.6	-0.1	-0.3	0.5	1.1	1.4	0.3	0.0	-2.1	-0.3	-1.2
Systolic Blood Pressure	0.3	1.6	9.9	0.7	1.0	0.2	-0.5	-1.9	-0.1	0.1	3.1	0.2	1.0
Smoking Status	0.7	1.6	5.2	-2.3	-1.6	-0.6	0.9	1.0	1.8	-1.4	0.3	-0.7	-0.9
Allergy or Eczema	0.2	0.6	4.2	0.1	-0.1	1.2	0.0	-0.3	-0.4	-2.1	-0.3	-0.2	0.5
Cardiovascular Disease	0.3	0.8	2.2	-0.6	1.5	0.9	1.2	1.1	0.4	-1.0	0.7	0.8	-0.0
Hypothyroidism (self reported)	1.0	2.4	6.5	-1.2	1.6	1.1	1.4	1.7	0.7	1.7	0.5	2.5	1.8
Respiratory disease	1.3	2.8	7.6	-0.2	-2.5	-2.8	-1.4	-1.6	0.1	1.0	1.3	-2.6	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.5	-0.0	-0.0	-0.5	-0.1	-0.4	-0.0	-0.5	-0.4	-0.7
Lung FEV1/FVC ratio	0.2	1.3	4.6	-1.5	0.3	0.9	-0.5	-1.4	1.1	-2.1	1.0	-0.6	0.4
Lung FVC	1.6	8.2	20.1	-1.3	3.5	3.9	3.2	3.6	-0.3	-1.9	0.1	4.5	2.3
Neuroticism	1.1	2.6	11.3	0.5	2.1	1.1	1.3	1.2	0.4	-0.8	1.2	3.4	1.8
Chronotype (morning person)	0.5	1.1	6.1	-1.1	-0.7	-0.2	0.9	0.4	2.5	0.0	-0.1	-0.9	1.3
Hair Pigment	0.1	1.6	7.0	-1.1	-1.1	0.0	0.2	0.2	2.1	-2.6	0.2	-1.6	-0.4
Tanning	0.1	1.1	2.7	-0.7	-1.6	-1.2	-0.3	0.3	0.5	-0.3	1.2	-1.6	1.1
Hand grip strength (left)	0.2	0.5	1.8	-0.5	-0.5	0.3	-0.8	-0.3	0.2	1.0	0.7	-1.3	0.0
Number of treatments/medications taken	0.3	0.5	1.6	-0.3	1.3	0.8	0.4	0.7	-0.6	-0.3	0.1	1.0	-0.7
Average weekly spirits intake	0.4	0.5	1.4	-0.1	0.1	0.3	-0.9	-0.8	-0.5	-0.1	1.2	-0.9	-1.0
Sensitivity / hurt feelings	0.1	0.2	1.0	-0.4	0.4	0.2	0.3	0.2	-0.3	0.4	-0.8	1.0	0.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.1	0.7	0.8	0.5	-1.8	-1.3	0.5	0.5	-0.9	0.3	-0.2
Hearing difficulty/problems: Yes	0.2	0.3	1.1	-0.3	0.3	0.7	-0.6	-0.2	1.1	-0.6	0.1	-0.3	0.2
Relative age of first facial hair	0.2	0.4	1.0	-0.6	-0.3	-0.8	-0.3	-0.5	1.0	-0.9	0.7	-0.2	0.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.7	-0.7	1.8	0.3	1.3	1.9	-0.5	-0.2	-1.2	1.4	-0.4
Ever used hormone-replacement therapy (HRT)	2.4	3.1	6.4	-1.6	2.0	1.8	2.1	2.1	1.7	-0.5	1.2	2.5	1.1
Ever had hysterectomy (womb removed)	1.4	1.6	9.7	-3.1	-1.0	-1.1	1.0	1.0	0.3	0.1	1.1	-0.1	-0.9
Systolic blood pressure, automated reading	0.6	1.7	5.8	2.3	-0.2	0.1	-1.2	-2.4	-0.1	-0.3	1.9	-0.5	0.7
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	5.0	-0.7	1.4	2.2	1.6	1.6	2.2	0.5	-0.6	1.3	0.9
Angina	1.0	1.3	3.1	-0.6	1.3	-0.4	1.6	1.6	-0.6	-0.1	-1.8	1.1	-0.8
Medication for hormone replacement therapy	1.2	1.4	3.0	-1.0	-1.2	-0.8	-1.0	-1.1	0.1	1.7	-0.1	-1.6	-1.7
Vitamin and mineral supplements	0.4	0.6	2.3	0.4	0.3	0.6	-0.8	-1.5	0.4	-0.8	0.9	0.1	0.5
Supplements: Zinc	1.4	1.6	5.4	-1.3	-2.3	-2.1	0.6	0.1	-0.6	-0.6	0.5	-1.6	-0.6
Medication: Co-codamol	0.9	1.1	3.9	0.4	0.8	-0.3	-1.2	-0.7	-0.7	0.5	-2.0	0.2	-1.9
Medication: Metformin	0.2	0.3	1.0	-1.0	-0.2	0.4	0.6	0.8	-0.2	-0.5	0.0	0.3	0.7
Diabetes (father)	0.3	0.4	1.5	0.6	0.9	0.6	0.1	0.2	-0.8	0.3	-0.4	0.6	1.2
Diabetes (mother)	1.5	1.9	5.0	0.7	-2.2	-2.0	-1.2	-1.0	-0.6	1.9	0.2	-1.1	-1.4
Severe depression (siblings)	0.6	0.7	3.1	1.1	0.0	0.3	-1.4	0.0	-0.6	1.8	-0.0	0.1	-0.5
Pack years adult smoking proportion	0.4	0.7	1.9	0.6	-0.9	-1.4	-0.1	-0.0	-1.1	-0.6	-1.4	-0.3	-0.2
Impedance of leg (right)	0.3	1.2	3.9	0.4	-1.1	-2.0	1.0	0.8	1.0	-1.9	-0.1	-0.8	-0.2
Leg fat-free mass (left)	0.3	1.7	6.4	0.0	-0.3	1.1	-2.5	-2.3	-0.3	1.3	0.8	-1.2	0.0
Trunk fat percentage	0.8	3.3	8.4	1.3	-1.1	-0.7	-2.9	-2.7	0.0	1.0	-1.9	-1.6	-2.5
Hand grip strength (right)	0.4	1.1	4.4	0.7	-0.6	0.1	-1.6	-1.2	-0.1	1.3	0.0	-2.1	-0.3
Townsend deprivation index at recruitment	1.7	2.4	4.9	-0.4	-1.6	-2.2	-1.3	-1.3	-2.1	0.5	-1.5	-1.9	-1.5
Current tobacco smoking	1.0	1.6	5.8	-0.9	-1.9	-2.4	0.9	1.4	1.0	-0.7	-1.3	-0.4	-0.4
Average weekly fortified wine intake	0.2	0.2	0.9	0.5	0.1	-0.5	0.6	0.9	-0.1	-0.5	-0.4	0.4	0.0
Maternal smoking around birth	0.5	0.8	1.8	-1.0	1.0	1.2	0.5	0.2	0.1	1.1	0.9	1.4	0.0
Fed-up feelings	0.7	1.2	4.2	0.2	1.9	1.0	1.0	0.7	-0.0	-0.6	-1.1	2.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.6	1.0	1.1	0.5	-1.2	-0.3	0.1	0.1	-1.6	0.2	-0.1
Relative age voice broke	1.1	1.6	4.7	0.4	0.1	-1.5	0.4	0.3	2.1	-2.2	1.4	0.0	1.6
Taking other prescription medications	0.6	1.0	3.0	-0.0	0.1	-0.8	-0.2	-0.2	-1.3	1.4	-1.6	0.3	-1.7
Age when periods started (menarche)	0.6	1.3	4.2	0.2	1.2	0.8	1.1	1.4	0.5	-2.1	0.3	1.2	1.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	2.2	-0.3	0.1	-0.5	-0.6	-0.5	-0.7	0.8	0.3	0.2	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	5.7	-0.0	1.7	1.9	-1.6	-0.1	1.5	2.4	-0.9	1.1	-0.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	4.5	-0.5	0.5	0.8	0.7	1.2	2.1	0.5	0.2	1.2	1.1
Qualifications: CSEs or equivalent	0.9	1.1	3.1	0.8	-1.4	-1.3	-1.4	-0.7	-0.4	0.3	-0.9	-1.8	-0.7
Serious illness, injury or assault to yourself	0.9	1.1	8.3	-0.0	0.1	-0.4	-0.2	0.6	-0.7	-0.6	-2.9	-0.7	-1.0
High blood pressure	0.1	0.3	1.2	-0.0	1.1	0.8	-0.2	0.1	-0.3	0.3	-0.5	0.6	-0.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.0	0.8	-0.2	0.6	-1.0	-1.1	-0.6	-1.4	-0.8	-0.9	-0.2
Multivitamins +/- minerals	0.5	0.6	2.2	-0.4	0.6	0.4	0.9	1.5	-0.5	0.5	-0.7	0.8	-0.6
Stomach or abdominal pain in last month	0.2	0.3	1.3	-1.2	-0.0	-0.4	0.2	-0.4	-0.3	0.8	0.8	0.2	-0.3
Supplements: Glucosamine	0.6	0.7	2.7	-0.5	0.1	0.4	1.5	1.6	0.5	-0.6	0.6	0.8	0.2
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	6.7	-0.8	-2.2	-1.1	-1.6	-1.8	-1.8	0.4	-1.6	-2.5	-2.6
Medication: Atenolol	4.6	5.8	13.5	-1.1	3.1	2.8	2.6	3.3	1.4	-1.6	0.5	3.7	1.8
Medication: Levothyroxine sodium	0.3	0.6	1.1	-1.1	0.5	0.8	0.4	0.9	0.1	0.9	0.3	1.0	0.8
Sitting height	0.5	3.5	13.8	-1.7	-0.5	0.6	1.0	1.2	0.0	-3.7	2.7	0.5	2.8
Chronic bronchitis/emphysema (father)	1.0	1.1	6.0	0.2	0.8	-0.4	0.6	1.4	0.1	0.4	-2.4	1.4	-0.1
High blood pressure (mother)	1.7	2.4	6.9	1.6	-0.7	-1.0	-2.3	-2.1	-2.6	0.7	1.2	-1.0	-0.2
Body mass index (BMI)	0.8	3.6	11.0	1.8	-0.6	0.2	-3.3	-2.7	-1.7	1.9	-0.9	-1.3	-2.2
Impedance of leg (left)	0.4	2.0	8.3	0.9	-1.8	-2.9	0.0	0.1	1.2	-1.4	-0.2	-1.6	-1.1
Leg predicted mass (left)	0.3	1.7	6.4	0.0	-0.3	1.1	-2.5	-2.3	-0.3	1.3	0.8	-1.1	0.1
Trunk fat mass	0.8	3.6	11.0	1.0	-1.2	-0.5	-3.3	-3.0	-0.1	1.3	-1.4	-1.9	-2.4
Waist circumference	0.8	2.8	7.6	1.3	-1.1	-0.4	-2.8	-2.3	-1.1	1.3	-0.9	-1.9	-2.2
Number of incorrect matches in round	1.3	2.2	7.4	-2.7	-1.7	-1.5	1.5	0.8	0.0	0.2	-1.7	-1.2	-1.6
Past tobacco smoking	1.2	2.2	5.2	1.8	-0.0	-1.5	-2.0	-2.3	-0.9	1.9	-1.8	-0.3	-0.3
Alcohol usually taken with meals	0.1	0.2	0.5	0.7	0.7	0.5	0.2	0.2	-0.2	-0.5	-0.2	0.0	0.2
Nervous feelings	0.8	1.4	3.7	1.6	1.7	0.6	0.2	-0.2	0.0	-0.7	0.9	1.9	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.7	-0.1	1.5	0.8	0.3	0.0	1.9	-0.3	0.9	1.7	1.6
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.4	0.8	0.9	0.3	0.6	0.8	-0.6	0.2	0.2	0.4
Hair/balding pattern: Pattern 2	2.5	3.2	17.1	-0.8	-1.7	-2.5	0.1	-0.3	0.9	-4.1	0.2	-1.9	0.3
Had menopause	4.2	5.3	14.3	-0.8	1.9	1.6	2.6	2.7	3.8	-0.6	0.7	2.6	3.2
Had other major operations	0.3	0.3	0.7	-0.5	0.5	0.6	0.8	0.4	0.7	-0.8	-0.6	0.5	-0.2
Forced vital capacity (FVC)	0.4	1.5	5.0	-0.7	1.3	1.6	0.6	0.4	0.8	-1.2	1.4	0.8	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.6	-0.3	1.6	1.5	-1.4	-0.2	1.6	1.0	-0.6	0.7	-0.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.6	1.1	0.7	0.2	-0.4	-0.1	-0.9	0.4	0.4	1.6	0.7
Qualifications: None of the above	0.5	1.0	2.9	0.2	1.1	0.7	0.2	0.6	1.2	0.7	1.7	1.5	0.8
Financial difficulties in last 2 years	0.8	1.1	4.4	-0.2	-0.7	-0.9	-1.0	-0.4	0.5	2.1	-1.5	-0.7	-1.0
Mouth/teeth dental problems	0.4	0.7	2.3	-1.2	-0.2	-0.3	-0.1	-0.5	-0.1	1.5	-1.2	-0.1	-0.9
Heart attack	1.2	1.5	3.3	-0.6	1.8	0.8	1.6	1.8	-1.1	-0.9	-0.3	1.8	0.2
Allergy	0.6	1.4	4.6	-0.4	1.3	1.1	1.8	1.5	0.7	0.6	0.2	2.1	0.5
Pain all over the body in last month	1.2	1.3	4.8	0.6	2.2	1.5	-0.1	0.4	0.4	-0.6	0.9	1.6	1.3
Diabetes (self-reported)	0.5	0.8	1.9	-1.2	-0.1	0.5	0.8	1.4	-0.3	-1.1	-1.3	0.4	-0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.9	1.0	0.8	0.3	-0.8	-0.9	-0.6	0.2	-1.4	-0.2	0.0
Medication: Ramipril	0.8	1.1	3.3	0.7	1.3	0.5	-1.5	-1.2	-0.1	1.8	-1.0	-0.1	0.1
Medication: Simvastatin	1.0	1.5	3.2	-1.2	1.1	1.8	1.3	1.0	0.8	-0.8	-0.1	1.7	1.5
Fluid intelligence score	1.4	2.9	9.2	2.6	-0.2	-0.5	-2.1	-2.1	-3.0	1.7	-0.6	-0.2	-0.6
Illnesses of siblings	0.2	0.3	1.1	-0.3	-0.1	-0.4	0.4	-0.6	0.2	-0.2	1.0	-1.1	0.1
Neuroticism score	1.3	2.8	11.0	0.8	2.5	1.3	1.4	1.1	0.1	-1.3	0.5	3.3	1.7
Weight	0.5	2.6	10.3	0.9	-0.9	0.1	-3.2	-2.8	-0.5	1.2	0.3	-1.9	-1.1
Impedance of arm (right)	0.5	2.6	7.1	-1.2	-0.9	-1.3	2.4	1.2	2.6	-2.7	-0.8	-0.1	0.4
Arm fat percentage (right)	0.9	3.4	8.7	1.2	-1.1	-0.6	-3.0	-2.8	-0.9	1.2	-1.9	-1.4	-2.6
Trunk fat-free mass	0.3	1.6	4.8	0.3	-0.8	0.4	-2.2	-1.7	-0.2	0.7	2.1	-1.5	0.7
Hip circumference	0.7	3.0	10.2	1.5	-1.4	-0.6	-3.2	-2.9	-0.5	0.8	0.1	-2.2	-1.2
Time employed in main current job	0.6	0.6	3.7	0.3	0.4	-0.4	-0.9	-0.8	0.1	1.9	0.8	0.2	0.3
Alcohol intake versus 10 years previously	0.6	0.8	4.6	-0.6	-1.1	-0.5	-0.1	-0.3	0.1	-0.6	-1.0	-0.7	-2.1
Father’s age at death	1.4	1.9	5.5	2.3	0.6	-0.1	-2.1	-2.1	-1.6	0.6	0.3	-0.8	0.7
Worrier / anxious feelings	2.2	4.2	14.0	-0.3	2.2	1.1	2.3	1.9	-0.0	-3.0	1.0	3.7	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.6	0.8	1.6	0.9	-1.0	-0.4	0.5	1.2	0.2	1.4	0.9
Falls in the last year	1.1	1.5	4.8	2.2	2.1	-0.5	0.1	0.5	-0.3	0.9	-0.6	1.8	0.4
Hair/balding pattern: Pattern 3	2.7	4.1	8.8	-1.1	1.9	2.3	2.2	2.9	-0.0	2.1	-2.1	3.0	-0.4
Number of live births	1.7	2.4	8.1	0.6	0.1	0.4	1.0	1.1	2.7	-0.3	2.9	0.9	2.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	4.2	-0.6	1.2	1.7	-0.6	-1.0	0.4	-1.2	1.2	0.0	2.0
Pulse rate	1.1	1.9	4.8	-0.7	-2.2	-0.4	-1.1	-1.6	-1.3	0.2	-0.6	-2.2	-1.8
Happiness	0.5	0.6	3.0	-0.2	-0.6	-0.8	-0.6	-0.6	0.7	-0.2	0.8	0.1	1.7
Noisy workplace	0.8	0.9	2.4	0.3	1.1	1.6	0.1	1.0	1.1	0.3	1.1	1.3	0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.2	-0.8	0.3	0.8	0.3	0.2	-0.9	-1.8	0.1	-0.0	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.8	0.0	0.7	1.7	-1.0	-0.3	-0.4	0.7	-1.0	0.9	-0.7
Mouth/teeth dental problems: Dentures	0.9	1.5	7.5	1.5	0.8	1.5	-0.4	0.1	0.7	-2.7	1.0	-0.0	0.4
Asthma	1.5	3.0	6.1	0.3	-1.5	-2.4	-1.8	-2.2	-0.0	1.2	2.5	-2.5	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.6	1.6	1.6	1.2	-0.5	-0.1	-1.4	-0.2	-0.2	1.1	-1.1
Medication: Cholesterol lowering	0.9	1.4	2.5	-0.3	1.4	1.4	1.1	0.5	0.5	-1.5	1.1	1.6	1.5
Depression (self-reported)	0.5	0.6	1.8	-0.9	1.1	0.9	-0.2	-0.5	0.5	0.1	0.2	1.3	0.6
Medication: Lansoprazole	0.9	1.0	2.8	0.6	-1.1	-1.7	-0.1	-1.0	-1.4	-0.2	-0.7	-1.4	-0.8
Prospective memory result	1.0	1.2	4.1	-0.8	0.5	0.3	1.1	1.6	2.0	-0.4	0.2	1.2	1.3
Lung cancer (father)	4.1	4.8	13.3	-0.5	2.5	1.9	2.2	2.7	2.1	1.3	0.9	3.6	2.4
Illnesses of mother	0.6	0.7	2.8	-0.8	0.6	1.2	0.1	-0.9	-0.1	-0.1	-1.7	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.4	0.1	1.1	1.9	-0.7	-0.5	0.6	-1.7	0.7	0.0	1.8
Pulse wave Arterial Stiffness index	0.5	0.5	2.2	1.5	0.0	0.8	0.4	0.1	0.3	-0.2	-0.3	0.2	1.4
Impedance of arm (left)	0.5	2.5	7.5	-1.5	-0.5	-1.0	2.3	1.1	2.3	-2.7	-1.4	-0.1	0.0
Arm fat mass (right)	0.9	3.8	12.3	1.4	-1.1	-0.3	-3.5	-3.2	-1.0	1.5	-0.8	-1.8	-2.2
Trunk predicted mass	0.3	1.6	4.7	0.4	-0.8	0.4	-2.2	-1.7	-0.1	0.8	2.1	-1.5	0.7
Standing height	0.2	2.3	5.9	-1.1	-1.0	-0.3	-0.5	-0.8	2.4	-1.4	2.4	-1.7	1.9
Length of working week for main job	2.1	2.3	7.2	-0.7	-1.7	-2.4	0.1	-0.1	-1.4	0.3	-2.7	-0.8	-1.9
Exposure to tobacco smoke at home	0.6	0.7	2.5	0.6	-0.5	-1.6	0.2	-0.1	-0.9	-1.3	0.7	-0.6	0.2
Breastfed as a baby	1.0	1.2	3.9	1.5	-1.0	-0.1	-0.4	-0.5	-0.2	0.8	2.0	-0.8	1.8
Tense / ‘highly strung’	1.0	1.7	5.5	0.4	2.3	1.6	0.4	-0.4	1.1	-0.4	1.1	2.0	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.2	0.7	1.6	1.2	-1.8	-1.3	0.1	1.6	0.4	1.2	0.7
Hair/balding pattern: Pattern 4	0.5	1.1	5.3	-2.3	0.4	0.2	1.6	1.1	0.5	-0.1	-0.4	1.2	0.6
Birth weight of first child	0.6	1.1	3.6	1.2	-0.8	-0.7	-1.9	-1.7	-0.7	0.3	0.5	-0.8	0.8
Peak expiratory flow (PEF)	0.5	1.2	4.1	-0.8	0.3	1.3	-1.8	-2.0	0.3	1.0	-0.2	-1.0	0.4
Pulse wave reflection index	1.2	1.5	4.0	1.4	1.7	1.0	0.6	1.2	0.5	0.4	-0.0	1.7	2.0
Ever highly irritable/argumentative for 2 days	2.3	2.7	8.5	2.5	-0.2	-1.4	-2.9	-2.2	-0.4	2.1	0.7	-0.6	0.4
Loud music exposure frequency	2.1	2.3	7.2	1.1	0.2	-0.5	-2.7	-1.9	-2.2	2.2	0.1	-0.3	-0.8
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.5	-0.1	-1.4	-1.3	-0.4	-0.6	-0.8	-0.6	-0.8	-1.9	-0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.3	1.3	-1.4	-0.9	-1.0	-0.4	0.2	-0.5	-0.2	-1.5	0.1
Blood clot in the leg (DVT)	0.4	0.5	2.1	-1.5	-0.2	0.1	-0.0	0.6	0.2	0.3	-1.5	0.1	-0.7
Medication: Paracetamol	0.7	1.1	4.7	2.2	0.9	1.0	-0.2	0.8	-0.5	-0.5	0.6	1.9	0.1
Headache pain in last month	0.8	1.4	4.7	-0.5	1.9	0.7	1.1	1.0	0.6	-1.0	0.1	2.2	1.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	5.0	-0.4	-1.9	-2.1	-0.9	-0.4	-0.4	1.4	-1.3	-1.9	-2.2
Glaucoma (self-reported)	0.6	0.7	2.2	-0.0	-1.5	-0.7	-0.8	-1.3	-0.1	-0.1	0.8	-1.0	-0.2
Gout (self-reported)	1.0	1.3	6.8	0.8	-0.2	0.4	-2.6	-1.8	-1.4	0.5	0.5	-0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.8	-1.5	1.7	1.3	1.1	1.5	0.2	1.7	-0.1	2.4	1.4
Medication: Amlodipine	0.9	1.3	4.0	-1.8	0.4	0.5	0.7	0.7	1.9	0.4	0.6	0.5	2.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.0	0.5	0.0	-0.5	-0.5	-0.1	-0.8	1.4	-0.9	-0.5	-1.3
Birth weight	1.7	3.7	8.4	-0.4	2.3	1.9	2.9	2.3	1.8	0.0	-0.3	2.9	1.6
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.9	0.3	2.2	2.2	0.4	0.9	1.6	-0.3	0.1	1.6	2.0
High blood pressure (siblings)	1.1	1.5	6.7	0.5	-0.7	0.6	-0.9	-0.8	-1.8	0.6	-1.6	0.1	-2.6
Forced vital capacity (FVC), Best measure	0.4	1.5	4.4	-0.1	1.2	1.8	0.6	0.8	0.9	-1.5	0.8	0.9	2.1
Body fat percentage	1.0	3.9	10.4	1.5	-1.2	-0.8	-3.2	-2.8	-0.5	1.2	-2.0	-1.8	-2.8
Leg fat percentage (right)	0.7	2.5	6.3	1.9	-0.8	-0.3	-2.5	-2.0	-1.0	0.9	-1.2	-1.4	-2.3
Arm fat-free mass (right)	0.5	2.4	9.3	0.8	-0.5	0.6	-3.0	-2.4	-0.7	1.4	1.6	-1.6	0.1
Exposure to tobacco smoke outside home	0.4	0.5	1.7	-0.5	-0.5	-0.5	0.2	0.2	-0.6	1.3	-1.3	0.6	0.0
Comparative body size at age 10	0.7	1.9	5.9	-0.0	-1.0	-0.3	-2.1	-2.4	-1.2	1.7	-0.4	-1.6	-0.5
Number of full brothers	0.1	0.2	0.5	-0.7	0.1	-0.1	0.1	0.4	-0.5	-0.5	-0.1	0.5	-0.5
Worry too long after embarrassment	1.0	1.7	4.7	0.3	1.4	0.7	1.6	1.2	0.1	-1.6	0.3	2.2	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.5	-0.1	1.5	1.9	-1.0	-0.6	0.4	1.5	-1.4	1.0	-1.1
Wheeze or whistling in the chest in last year	0.4	0.8	2.0	-0.5	-1.3	-1.2	-0.4	-0.2	-0.8	-0.2	-0.3	-1.2	-1.4
Number of children fathered	1.0	1.1	4.8	2.2	0.7	1.1	-0.5	0.1	0.2	1.7	-0.4	1.0	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.0	-0.4	-0.7	-0.9	-1.0	-1.4	-0.7	0.3	0.4	-1.4	-1.0
Age at first live birth	0.8	1.5	4.5	-1.5	-0.4	0.9	-0.6	-0.1	-0.5	1.5	-1.9	-0.7	-2.1
Pulse wave peak to peak time	0.4	0.5	2.5	-1.6	-0.0	-0.9	-0.3	-0.0	0.1	0.3	0.3	-0.2	-1.2
Health satisfaction	0.2	0.3	0.8	-0.1	0.1	0.0	-0.7	-0.9	0.5	0.8	-0.3	0.1	0.5
Shortness of breath walking on level ground	0.9	1.1	4.7	0.1	1.1	1.1	-0.7	-0.0	0.6	2.2	0.4	1.2	1.1
Qualifications: College or University degree	0.5	1.6	6.5	-1.6	-0.4	-0.7	-0.2	-1.3	0.3	-1.2	2.5	-0.9	1.4
Eye problems/disorders: None of the above	0.4	0.5	1.9	0.4	0.6	-0.1	-1.4	-1.3	-0.8	0.3	0.4	-0.2	-0.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.3	0.4	-1.8	-1.1	-0.3	-0.4	-0.6	1.2	-1.7	-1.8	-1.1
Emphysema/chronic bronchitis	0.7	0.7	2.5	-1.2	0.1	-0.2	1.0	1.6	1.0	0.7	-0.5	0.6	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	-0.0	0.4	0.6	0.3	-0.3	0.8	0.2	-0.9	-0.8	0.8
Neck or shoulder pain in last month	1.6	2.3	6.4	0.1	2.2	1.4	2.0	2.5	0.0	-0.3	0.1	2.5	-0.2
Medication: Blood pressure	1.1	2.0	5.5	0.0	2.2	2.4	0.1	0.0	0.3	-0.3	0.9	2.0	2.1
Angina (self-reported)	1.0	1.3	3.0	-0.3	1.3	-0.6	1.7	1.7	-0.7	-0.2	-1.7	0.9	-0.9
Migraine (self-reported)	0.5	0.7	2.8	-0.6	0.8	-0.4	-1.1	-1.2	0.2	1.7	0.3	0.1	-0.3
Medication: Ibuprofen	1.3	1.5	5.8	2.4	1.4	0.8	-1.1	-0.6	-1.4	-0.1	-0.5	0.5	-1.7
Medication: Allopurinol	0.7	0.9	4.1	-0.8	-0.2	0.8	-2.0	-1.2	-1.1	0.2	0.2	-0.3	-0.9
Medication: Omeprazole	0.8	0.9	2.5	-0.4	-0.8	0.0	-1.6	-1.1	-1.1	0.8	0.3	-0.2	-1.5
Medication: Seretide 50 evohaler	1.2	1.4	2.5	-0.3	-0.8	-1.5	-1.5	-1.6	-1.1	1.3	0.1	-1.5	-1.2
Mean time to correctly identify matches	0.7	1.3	4.1	-1.2	-0.3	-0.7	1.7	1.5	-0.8	-2.0	-1.0	0.5	-0.6
Heart disease (mother)	1.4	1.7	5.3	-1.3	0.2	-0.2	2.1	2.3	-0.1	-0.6	0.8	1.6	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.5	1.0	-1.0	-1.0	-1.2	-1.6	-1.4	-1.0	-0.1	-0.8	0.4
Whole body fat mass	1.0	4.2	13.4	1.2	-1.2	-0.5	-3.7	-3.2	-0.5	1.5	-1.4	-2.0	-2.5
Leg fat mass (right)	0.9	3.3	11.2	1.5	-0.9	-0.0	-3.4	-2.7	-1.0	1.4	-0.8	-1.7	-2.2
Arm predicted mass (right)	0.5	2.8	11.0	1.1	-0.4	0.6	-3.3	-2.5	-0.4	1.7	1.7	-1.6	0.2
Pulse rate, automated reading	0.2	0.8	2.1	0.4	-0.7	0.4	0.1	-0.3	-1.4	-1.4	-1.0	-0.8	-1.0
Alcohol intake frequency.	0.5	1.2	3.1	1.0	0.6	1.0	-0.1	0.1	-1.8	1.5	-1.2	1.2	-1.1
Comparative height size at age 10	0.6	3.2	9.4	-0.1	-2.4	-2.5	-1.6	-2.3	1.2	0.7	1.3	-3.1	-0.1
Number of full sisters	0.4	0.4	1.9	-0.7	-0.7	-0.4	-0.3	0.0	0.9	1.4	0.2	0.4	0.4
Suffer from ‘nerves’	1.6	2.5	6.9	2.6	1.5	1.4	-1.9	-1.8	-0.1	2.3	0.8	1.0	0.4
Overall health rating	0.3	0.7	2.6	0.0	1.6	-0.1	-0.9	-0.0	1.3	0.9	0.5	0.8	0.1
Chest pain or discomfort	0.9	1.3	3.3	-1.7	0.5	-0.7	1.3	1.8	-0.6	1.3	-0.2	1.2	-0.8
Had major operations	0.4	0.5	1.3	-0.5	1.1	0.8	1.1	0.4	0.8	-0.2	0.1	0.4	0.7
Age at last live birth	0.6	0.9	3.5	-1.1	-0.6	0.1	-1.2	-1.1	-0.2	1.9	0.1	-0.3	-0.9
Family relationship satisfaction	1.2	1.5	3.3	-0.4	1.5	1.7	0.2	0.1	1.6	0.4	1.6	1.0	1.8
Leg pain on walking	0.9	1.1	7.3	-0.1	-0.4	-0.0	-1.4	-0.5	0.8	2.7	0.7	-0.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	4.9	1.0	0.2	0.8	-0.3	0.6	-0.1	0.9	-2.2	-0.2	-1.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.8	-0.9	0.4	0.2	0.4	0.2	-0.8	1.9	-0.5	0.6	-1.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	8.5	-0.2	-0.5	-0.5	0.8	0.2	0.4	-0.7	2.9	-0.3	0.5
Medication: Aspirin	1.2	1.5	4.8	-2.0	-0.3	0.1	1.8	2.2	0.7	-1.5	0.4	0.8	0.0
Supplements: Vitamin C	1.1	1.3	3.7	-1.9	-1.7	-1.3	0.9	0.9	0.5	1.1	-0.6	-1.0	-0.7
Knee pain experienced in last month	1.4	2.2	7.9	2.8	2.0	-0.3	0.2	1.6	0.3	0.4	0.4	2.5	0.7
Hypertension (Self-reported)	0.1	0.4	1.7	0.1	1.3	1.1	-0.3	0.0	-0.0	0.1	-0.7	0.4	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.8	0.7	-1.0	-1.4	-1.0	-0.6	0.1	0.5	1.7	-0.5	1.1
Illnesses of father: Heart disease	1.0	1.4	6.6	-2.6	-0.8	-0.7	0.5	-0.2	-1.2	-0.6	-0.5	-0.4	-1.9
Illnesses of siblings: Diabetes	0.7	0.8	4.6	1.4	0.4	0.2	-0.8	0.1	0.3	0.5	0.7	0.4	2.1
Smoking status: Previous	1.4	2.2	6.0	-1.8	1.0	2.4	1.6	1.9	0.3	-1.2	1.7	0.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.8	-0.3	-0.3	0.0	-0.3	-0.6	0.5	-0.8	0.7	-0.5	0.9
Whole body fat-free mass	0.3	2.0	7.0	0.3	-0.6	0.6	-2.6	-2.2	-0.2	1.3	1.7	-1.6	0.4
Leg fat-free mass (right)	0.4	1.9	7.3	0.1	-0.4	0.8	-2.7	-2.5	-0.1	1.4	1.0	-1.4	-0.1
Arm fat percentage (left)	0.9	3.5	8.4	1.1	-0.8	-0.2	-2.9	-2.7	-1.0	1.2	-2.3	-1.4	-2.8
Average weekly red wine intake	0.7	1.0	2.6	-1.4	-0.2	-0.0	-0.3	-0.4	-1.5	-1.6	-1.1	-0.9	-0.6
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.9	0.3	1.8	0.2	1.1	0.7	1.3	-2.2	0.7	1.3	1.8
Mood swings	0.3	0.6	2.9	-0.3	0.9	0.8	0.6	0.8	0.5	0.0	-0.6	1.7	0.1
Loneliness, isolation	0.7	0.9	4.2	0.1	1.8	0.3	0.4	0.6	0.8	0.3	0.3	2.0	0.9
Long-standing illness, disability or infirmity	1.1	1.6	5.7	-0.4	0.8	-0.5	0.2	0.8	-0.7	2.0	-2.4	0.7	-2.0
Ever had bowel cancer screening	0.4	0.5	1.6	0.7	1.2	0.9	-0.0	0.3	-0.1	-0.2	-0.5	1.2	-0.3
Diabetes diagnosed by doctor	0.4	0.6	1.4	-0.7	0.5	1.2	0.7	1.0	-0.7	-0.9	-0.9	0.7	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	5.3	-0.1	-0.6	-0.3	-1.9	-2.3	-0.4	1.5	0.4	-1.8	-1.8
Friendships satisfaction	0.7	0.9	3.7	0.6	0.5	0.5	-0.2	-0.6	1.2	-0.7	1.9	0.6	1.4
Qualifications: nursing, teaching	0.8	1.2	3.3	-1.8	-1.1	-1.8	1.1	0.7	-0.5	-1.2	-0.1	-0.8	-0.5
Commuting to job workplace: Walk	0.8	0.9	2.8	1.7	1.0	1.5	-0.0	0.5	0.6	-0.7	-0.2	0.7	1.1
Eye problems/disorders: Cataract	0.7	0.8	1.9	-0.3	-0.0	-0.8	1.4	1.2	0.9	-1.3	-0.9	0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.5	-0.5	0.7	-0.2	1.0	0.5	0.4	0.3	1.6	1.1	0.8
Medication for cholesterol	0.5	0.7	3.8	1.9	-0.5	-0.5	-1.2	-0.8	-0.7	0.4	0.1	0.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	3.2	-0.1	0.3	0.4	-0.4	-0.4	-0.5	0.2	-1.8	0.8	-0.1
Back pain experienced in last month	1.1	1.6	3.5	-0.8	1.2	0.4	1.9	1.6	1.8	-1.9	0.6	0.9	-0.1
Mineral and other dietary supplements	0.2	0.3	1.0	0.2	0.2	0.7	-0.6	-1.0	0.5	-0.6	0.2	-0.0	-0.1
Breast cancer (self-reported)	0.9	1.1	4.1	-0.9	-0.5	-0.0	-0.4	-0.8	-1.2	1.2	-1.2	-0.8	-2.0
Asthma (self-reported)	1.6	3.2	7.2	0.4	-1.8	-2.6	-1.8	-2.1	0.3	1.2	2.3	-2.7	0.2
Osteoporosis (self-reported)	1.1	1.3	4.2	2.0	-1.0	-1.2	0.3	-0.2	-1.7	-1.4	-0.1	-1.1	-0.6
Osteoarthritis (self-reported)	2.3	3.0	10.6	0.4	3.3	1.9	-0.5	0.1	-0.9	2.5	0.4	2.6	1.0
Medication: Aspirin	1.1	1.4	4.1	-1.7	-0.4	0.0	1.6	2.0	1.1	-1.6	-0.0	0.8	0.0
Medication: Gliclazide	1.1	1.2	3.1	0.6	1.6	1.0	1.4	1.1	0.7	-0.0	-0.1	1.8	1.1
Illnesses of father: None of the above (group 1)	0.5	0.7	2.3	-1.5	-0.9	-0.4	-0.4	-0.4	1.0	0.7	0.6	-1.0	0.4
Smoking status: Current	1.0	1.6	5.4	-0.7	-1.9	-2.3	1.0	1.5	1.2	-0.7	-0.9	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	8.5	0.1	1.8	2.9	1.3	1.4	0.8	-0.7	-0.0	1.7	2.6
Whole body water mass	0.4	2.1	7.2	0.3	-0.7	0.6	-2.7	-2.3	-0.3	1.4	1.6	-1.7	0.4
Leg predicted mass (right)	0.4	2.0	7.7	0.1	-0.4	0.9	-2.8	-2.5	-0.1	1.5	0.9	-1.4	-0.2
Arm fat mass (left)	0.9	3.7	11.2	1.3	-1.0	-0.1	-3.4	-3.1	-1.1	1.4	-1.2	-1.8	-2.5
Number of self-reported non-cancer illnesses	0.5	0.9	2.4	-0.9	1.3	-0.8	-0.5	-0.2	-0.1	1.5	1.1	0.8	0.9
Average weekly champagne plus white wine intake	0.8	1.1	4.4	-0.4	-1.8	-1.0	-0.6	-0.7	-0.4	-0.7	2.1	-0.5	0.6
Miserableness	0.4	0.6	1.5	0.6	0.8	0.4	-1.1	-1.2	-0.3	-0.2	1.2	0.5	0.8
Guilty feelings	1.1	1.7	6.6	0.2	1.9	1.0	1.6	1.4	-0.7	-0.2	-0.7	2.6	0.2
Wears glasses or contact lenses	2.1	2.4	6.0	-1.4	0.9	0.8	2.2	2.1	1.4	-2.4	-0.7	1.4	1.0
Ever taken oral contraceptive pill	0.5	0.5	1.8	0.6	-0.3	-1.1	-1.3	-0.3	0.3	1.2	0.3	-0.3	-0.0
Hearing aid user	0.4	0.5	1.8	1.4	1.1	0.9	0.0	0.1	-0.3	-0.8	-0.6	0.3	0.0
Mother’s age at death	1.7	2.2	7.2	-0.7	-1.9	-1.9	-0.8	-1.2	-1.5	-0.3	0.1	-2.7	-1.6
Financial situation satisfaction	0.5	0.6	2.8	0.4	-0.8	-1.2	-0.7	-0.2	0.5	0.3	1.7	-0.3	0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.8	-0.7	-0.6	-0.7	-0.1	-0.3	1.3	1.2	0.4	-0.4	0.1
Commuting to job workplace: Public transport	0.9	1.0	5.2	0.2	-0.3	0.3	-0.0	-0.9	-1.1	-2.3	1.4	-0.6	0.6
Eye problems/disorders: Glaucoma	0.3	0.4	1.7	-1.1	-0.3	0.5	1.3	0.4	-0.3	-0.1	0.4	0.2	0.2
Medication: Blood pressure	0.7	1.3	3.7	-1.0	1.5	0.2	1.2	1.5	1.9	-0.5	0.5	1.1	0.8
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.6	-0.8	1.1	0.3	0.7	1.9	0.5	0.9	-1.2	1.9	-0.3
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.9	-1.3	1.3	0.8	1.4	2.2	1.0	0.8	-0.2	1.7	1.0
High cholesterol (Self-reported)	0.5	1.0	3.5	-0.5	0.5	0.6	0.7	0.6	0.4	-1.6	1.9	0.7	1.1
Medication: Bendroflumethiazide	0.5	0.8	3.4	-1.2	0.0	0.4	1.2	0.7	0.6	-1.8	0.7	-0.3	0.1
Medication: Paracetamol	0.8	1.3	6.4	2.5	0.8	0.9	-1.3	0.2	-0.8	0.4	0.2	1.5	-0.3
Medication: Lisinopril	1.9	2.4	8.6	-1.9	0.9	1.1	2.1	1.5	2.9	-0.9	1.0	0.8	0.9
Medication: Atorvastatin	0.9	1.1	2.3	-0.3	0.8	0.7	1.4	1.0	0.6	-1.5	0.9	1.2	1.4
Illnesses of father: High blood pressure	0.5	0.6	1.5	1.2	0.7	-0.3	-0.2	0.5	-1.2	-1.1	-0.8	0.2	-0.6
Alcohol drinker status: Never	1.7	2.0	7.7	1.2	2.8	2.7	0.4	0.4	0.2	-0.5	-0.2	1.8	0.5
Ever smoked	1.0	1.8	6.5	-1.9	-0.8	0.1	1.8	1.6	0.7	-2.5	1.0	-0.2	-0.1
Basal metabolic rate	0.4	2.3	8.8	0.5	-0.8	0.4	-3.0	-2.6	-0.4	1.3	1.3	-1.8	-0.0
Leg fat percentage (left)	1.1	3.8	9.9	2.3	-1.2	-0.7	-3.2	-2.4	-0.9	1.2	-1.3	-1.8	-2.8
Arm fat-free mass (left)	0.5	2.5	9.1	1.1	-0.5	0.5	-3.0	-2.4	-0.6	1.5	1.8	-1.5	0.2
Number of operations (self-reported)	0.2	0.3	0.7	0.2	0.6	0.1	0.1	0.5	-0.4	0.3	-0.9	0.8	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.5	-0.5	0.1	0.1	0.0	0.5	0.1	0.3	-0.1	-0.0	0.7
Irritability	0.6	0.9	4.1	-0.6	-1.0	-1.2	0.3	-0.9	0.5	-2.0	0.2	-0.4	-1.0
Risk taking	0.4	0.5	2.6	1.4	-0.4	-0.2	0.0	0.2	0.3	1.6	0.7	-0.1	0.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.1	1.8	-0.2	1.0	0.2	0.5	0.4	-0.4	1.0	0.5	1.4
Fractured/broken bones in last 5 years	2.5	3.2	9.1	2.1	1.3	1.7	1.6	0.8	1.4	-1.8	2.2	0.9	3.0
Age started oral contraceptive pill	2.0	2.5	5.5	-0.7	0.2	0.0	2.3	1.7	2.0	-2.3	0.8	1.7	1.8
Diastolic blood pressure, automated reading	1.6	5.1	17.3	3.9	0.0	0.1	-3.4	-4.2	-1.7	1.2	0.8	-1.1	-0.4
Ever depressed for a whole week	0.6	0.8	2.2	1.0	0.6	-0.1	-0.6	-0.9	-0.8	-0.7	1.1	0.8	1.5
Unable to work because of sickness or disability	0.5	0.6	1.9	0.7	1.2	0.4	0.4	0.7	0.5	0.6	-0.9	1.4	0.3
Commuting to job workplace: Cycle	1.3	1.6	5.2	-0.7	-2.3	-1.7	-0.2	-0.0	0.2	1.7	0.8	-1.7	-1.0
Myopia	0.4	0.6	2.0	-1.4	0.3	0.0	0.5	1.0	1.2	-0.4	-0.6	0.7	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.9	0.4	-1.7	-1.3	-0.5	-0.8	0.3	0.5	0.9	-1.1	0.1
Cholesterol lowering medication	0.9	1.4	3.9	-1.2	0.5	1.0	1.9	2.0	1.2	-0.4	-0.6	1.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.9	-0.0	-0.9	-0.4	-1.4	-0.9	-1.1	0.2	0.6	-0.3	-1.4
Pain experienced in last month	2.8	4.7	11.8	-0.1	-3.1	-2.7	-2.1	-2.5	-1.5	0.8	-1.8	-3.4	-1.3
Supplements: Calcium	2.2	2.4	7.6	1.9	-2.8	-1.8	0.8	0.5	-1.7	-1.4	-0.1	-1.6	-1.0
Basal cell carcinoma (self-reported)	0.4	0.4	1.0	-0.4	0.5	0.6	1.0	0.9	-0.7	-0.8	0.0	0.7	-0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.8	-0.7	1.5	0.6	1.5	1.7	-1.1	-0.9	-0.5	1.5	0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.0	-1.4	-0.2	-0.2	-0.1	0.6	0.0	0.2	-1.4	0.1	-0.6
Heart disease (siblings)	1.2	1.5	2.8	-1.6	0.8	0.4	1.7	1.5	-0.8	-1.2	-1.6	1.3	0.4
Alcohol drinker status: Previous	0.8	0.9	2.7	-0.5	-0.1	-0.0	1.6	1.2	-0.7	-1.1	1.2	0.6	1.0
Pack years of smoking	0.4	0.6	2.2	0.5	-0.7	-1.0	0.4	0.5	-0.8	-0.8	-1.5	-0.0	-0.1
Impedance of whole body	0.3	1.8	4.9	-0.4	-1.1	-2.0	1.4	0.8	1.9	-2.2	-0.9	-0.7	-0.3
Leg fat mass (left)	1.2	4.5	15.0	1.9	-1.3	-0.4	-3.9	-3.1	-1.1	1.5	-0.9	-2.1	-2.6
Arm predicted mass (left)	0.5	2.6	9.4	1.3	-0.8	0.2	-3.1	-2.5	-0.8	1.3	1.7	-1.7	0.1