TWAS hub - DYNC2H1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1120	0.0400	6.6e-04	0.049	NA	0.040	NA	0.047	1.5e-04	NA	5.1e-04	NA	2.0e-04
2	TCGA	Glioblastoma Multiforme	0.2480	0.1270	2.5e-03	0.079	0.101	0.093	NA	0.101	2.2e-03	5.7e-04	9.1e-04	NA	5.6e-04
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0796	0.0333	3.4e-07	0.024	0.069	0.065	NA	0.057	9.8e-04	3.0e-08	8.4e-08	NA	5.1e-07
4	TCGA	Brain Lower Grade Glioma	0.0935	0.0396	1.9e-06	0.050	0.032	0.042	NA	0.031	2.2e-06	1.2e-04	1.4e-05	NA	1.8e-04
5	TCGA	Lung Squamous Cell Carcinoma	0.0795	0.0616	5.0e-03	-0.001	0.022	0.018	NA	0.005	3.9e-01	1.3e-03	3.6e-03	NA	6.9e-02
6	TCGA	Prostate Adenocarcinoma	0.3277	0.0947	8.7e-05	0.029	0.024	0.051	NA	0.041	4.7e-04	1.4e-03	4.6e-06	NA	3.9e-05
7	TCGA	Thyroid Carcinoma	0.0620	0.0390	8.5e-03	0.021	0.025	0.052	NA	0.047	3.3e-03	1.6e-03	7.6e-06	NA	2.2e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Migraine (self-reported)	5.8	7.2	17.6	-1.9	-2.9	-3.3	-1.7	-4.2	-0.8	-2.6
Eye problems/disorders: Cataract	4.2	4.9	11.3	2.0	2.1	3.4	1.8	3.3	-0.3	0.8
Number of treatments/medications taken	4.0	7.2	12.6	3.5	3.1	3.3	3.3	2.3	-1.2	0.1
Mouth/teeth dental problems: Loose teeth	3.7	4.4	13.5	-0.6	2.4	0.7	1.1	2.9	1.0	3.7
High blood pressure	3.6	10.1	17.6	3.8	3.2	4.2	4.1	3.1	0.4	1.4
Wears glasses or contact lenses	3.6	4.2	8.5	2.0	-0.1	2.9	1.5	2.4	1.8	2.4
Cardiovascular Disease	3.5	11.6	23.0	4.1	3.7	4.1	4.8	3.1	0.1	1.0
High cholesterol (Self-reported)	3.5	6.2	15.4	2.6	3.9	1.9	3.5	2.0	-1.4	-0.3
Had other major operations	3.4	4.2	9.4	1.2	2.0	1.7	1.7	3.1	2.0	2.2
Eye problems/disorders: None of the above	3.3	3.8	7.9	-2.2	-2.2	-2.8	-1.6	-2.4	0.9	-0.4
Vascular/heart problems diagnosed by doctor	3.1	8.6	15.0	-3.7	-2.8	-3.9	-3.6	-3.1	-0.2	-1.1
Leg pain on walking	3.0	3.7	5.6	1.4	2.4	1.8	2.3	1.8	-2.4	-1.1
Hypertension (Self-reported)	2.9	8.0	16.5	3.2	3.3	3.3	4.1	2.7	-0.1	0.9
Medication: Bendroflumethiazide	2.9	4.4	6.8	2.6	0.9	2.5	2.2	2.1	2.3	1.5
Medication: Blood pressure	2.8	5.4	11.6	3.2	2.7	2.1	3.4	1.9	0.2	0.7
Pulse wave Arterial Stiffness index	2.7	3.1	6.6	2.1	-1.0	2.6	-0.4	2.1	1.2	1.9
Medication: Amlodipine	2.5	3.5	13.4	3.7	0.9	2.6	1.5	1.1	-0.2	-0.5
Number of self-reported non-cancer illnesses	2.5	4.4	7.1	2.1	2.2	2.7	2.5	2.6	0.0	1.4
Number of operations (self-reported)	2.5	3.8	7.7	1.9	0.5	2.0	0.7	2.8	2.8	1.6
Systolic blood pressure, automated reading	2.4	6.9	15.1	2.5	3.6	3.0	3.9	2.0	-0.9	1.2
Pulse wave peak to peak time	2.4	2.9	6.5	-2.0	0.8	-2.5	0.2	-2.1	-1.0	-1.9
Mother’s age at death	2.4	3.1	6.5	0.8	-2.5	-0.6	-2.5	-1.9	0.5	-1.9
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	4.4	1.5	0.9	2.0	2.1	1.8	0.3	1.5
Body mass index (BMI)	2.3	9.7	24.6	0.5	5.0	2.5	4.1	4.0	0.2	2.2
Waist circumference	2.3	8.3	16.4	1.6	4.1	2.9	3.7	3.7	0.7	1.7
Gout (self-reported)	2.3	3.2	5.9	2.0	2.4	2.0	1.1	2.1	1.0	1.4
Number of children fathered	2.3	2.5	8.1	-1.6	-1.1	-1.8	-2.9	-1.2	0.8	-0.8
Medication: Blood pressure	2.3	4.1	8.9	1.6	1.3	2.8	3.0	2.4	-0.6	1.3
Cholesterol lowering medication	2.2	3.2	8.7	2.2	2.4	1.2	3.0	1.0	-0.6	0.6
Length of working week for main job	2.1	2.3	5.0	-2.2	-0.9	-2.2	-1.3	-2.0	0.3	0.0
Illnesses of father: Heart disease	2.1	3.0	7.8	1.4	1.5	2.4	2.8	1.2	-0.9	0.8
Prostate Cancer	2.0	2.8	8.1	-0.1	-1.0	-0.8	-2.8	-2.6	0.3	-1.7
Diabetes (father)	2.0	2.5	6.6	1.9	1.7	1.7	2.6	0.3	-0.8	0.9
Leg fat percentage (right)	2.0	7.2	15.4	1.1	3.9	2.5	3.0	3.7	0.7	2.0
Illnesses of father: None of the above (group 1)	2.0	2.5	5.5	-1.0	-1.9	-1.5	-2.4	-1.7	0.7	-1.1
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	6.2	-1.5	-2.1	-1.9	-2.5	-2.0	1.1	-0.0
Leg fat mass (right)	1.9	7.2	18.9	0.7	4.3	2.3	3.2	3.8	0.1	1.2
Leg fat percentage (left)	1.9	7.0	14.6	0.2	3.7	2.2	3.0	3.8	0.6	2.5
Leg fat mass (left)	1.9	7.2	18.7	0.2	4.3	2.1	3.2	3.8	-0.0	1.6
BMI	1.7	9.6	20.8	0.5	4.6	2.8	4.3	3.6	-1.5	2.0
Waist Hip Ratio (WHR)	1.7	7.7	22.2	4.7	0.7	4.3	2.7	1.6	0.8	1.4
Severe depression (siblings)	1.7	1.9	4.0	-1.1	-0.4	-1.8	-2.0	-0.9	-0.0	-1.9
Taking other prescription medications	1.7	2.6	7.0	1.6	2.6	1.8	1.6	1.1	-1.3	0.0
Age when periods started (menarche)	1.7	4.1	9.8	-2.8	-1.9	-2.1	-3.1	-1.1	1.4	0.6
Serious illness, injury or assault to yourself	1.7	2.1	4.2	1.2	0.4	1.2	1.3	2.1	1.8	1.6
Number of incorrect matches in round	1.7	2.8	6.8	-1.9	-1.8	-1.2	-2.6	-0.9	-1.3	-1.3
Financial difficulties in last 2 years	1.7	2.3	5.1	-1.7	0.3	-2.0	-0.8	-1.1	-2.2	-1.5
Impedance of arm (right)	1.7	7.8	21.5	-1.2	-4.6	-1.8	-4.2	-2.8	0.6	-1.3
Heart disease (mother)	1.7	2.0	3.6	1.5	1.2	1.6	1.5	1.9	1.2	0.6
Commuting to job workplace: Car/motor vehicle	1.7	1.9	6.8	1.6	-0.1	0.5	0.2	1.7	2.6	1.0
Arm fat mass (left)	1.7	7.1	19.4	0.3	4.4	2.1	3.3	3.6	0.2	1.5
Pack years of smoking	1.7	2.5	6.1	0.3	2.5	1.6	1.3	2.3	0.3	1.2
Illnesses of siblings	1.6	2.3	5.3	-1.1	-1.4	-1.4	-2.3	-1.7	-1.1	-1.2
Noisy workplace	1.6	2.0	5.9	2.4	1.3	0.9	1.6	1.2	1.1	0.2
HbA1C	1.5	1.7	3.7	1.4	0.6	1.9	1.8	1.2	0.8	0.7
Lupus	1.5	2.3	6.8	0.5	1.7	2.6	0.7	2.2	-0.7	0.3
Forced vital capacity (FVC)	1.5	5.8	9.7	-1.9	-2.0	-2.7	-3.1	-2.5	-0.6	-3.1
Arm fat percentage (right)	1.5	6.0	12.4	0.1	3.5	2.1	2.9	3.5	0.6	2.1
Impedance of arm (left)	1.5	6.9	20.9	-1.4	-4.6	-1.4	-3.9	-2.7	0.2	-1.1
Arm fat mass (right)	1.5	6.2	16.2	0.5	4.0	2.0	3.2	3.2	0.5	1.4
Body fat percentage	1.5	6.0	13.5	-0.0	3.5	2.1	2.7	3.7	0.4	2.1
Arm fat percentage (left)	1.5	6.2	14.2	-0.0	3.8	2.2	3.0	3.4	0.3	1.9
Medication for cholesterol	1.5	2.3	5.7	-2.1	-2.4	-0.8	-2.1	-0.7	-0.3	-0.8
Financial situation satisfaction	1.5	1.9	5.0	1.0	2.2	0.7	1.4	0.4	-2.0	-0.7
Alcohol drinker status: Never	1.5	1.8	6.2	0.5	-2.5	-0.8	-1.8	-1.1	0.6	-0.7
Impedance of whole body	1.5	7.8	24.6	-1.0	-5.0	-1.8	-4.0	-2.9	0.8	-0.8
Pack years adult smoking proportion	1.4	2.1	6.0	0.2	2.4	1.2	1.4	2.1	0.1	1.1
Medication: Simvastatin	1.4	2.1	4.8	1.5	2.2	1.0	2.0	0.7	-1.4	-0.0
Alcohol intake versus 10 years previously	1.4	2.1	6.5	0.3	-2.6	-1.5	-1.3	-1.2	1.7	-0.2
Whole body fat mass	1.4	5.9	16.6	0.1	4.1	1.8	3.0	3.4	-0.2	1.2
Diastolic blood pressure, automated reading	1.4	4.4	8.6	1.5	2.9	2.3	2.7	1.7	-0.3	2.0
Bipolar Disorder (2018)	1.3	2.0	7.3	2.7	-1.2	1.0	1.3	-0.0	1.7	0.4
Primary Biliary Cirrhosis	1.3	1.8	4.8	-0.1	-2.0	0.3	-0.9	0.5	1.7	2.2
Lung cancer (father)	1.3	1.6	3.8	0.5	1.0	1.6	1.9	1.3	0.2	1.3
Worry too long after embarrassment	1.3	2.1	4.4	-0.5	1.2	1.2	1.2	2.1	-2.0	1.3
Average weekly beer plus cider intake	1.3	1.9	5.2	-1.4	2.2	0.2	0.8	0.7	-2.3	-0.2
Myopia	1.3	1.9	8.9	0.6	3.0	0.5	1.2	1.4	-0.3	-0.5
Alzheimer’s Disease (in mother)	1.2	1.4	3.6	0.0	0.4	1.4	1.4	1.4	0.2	1.9
Rheumatoid Arthritis	1.2	1.7	4.7	0.2	1.0	1.1	2.2	1.4	-0.1	1.7
Blood Red Count	1.2	11.6	27.4	5.2	2.6	3.9	2.4	3.2	3.1	2.4
Impedance of leg (right)	1.2	5.6	17.5	0.8	-4.2	-1.1	-3.4	-2.4	1.3	-1.1
Qualifications: CSEs or equivalent	1.2	1.6	7.0	-0.1	1.0	1.3	0.7	0.9	0.5	2.6
Impedance of leg (left)	1.2	5.7	19.1	-0.5	-4.4	-1.7	-3.5	-2.1	0.9	-0.5
Mouth/teeth dental problems: Dentures	1.2	2.0	3.2	1.7	0.9	1.8	0.1	1.7	1.4	1.5
Loud music exposure frequency	1.2	1.3	3.8	-1.2	-0.3	-2.0	-1.0	-1.5	0.3	-0.3
Comparative body size at age 10	1.2	3.2	9.9	0.0	3.1	0.3	2.0	0.5	-2.5	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.3	0.1	-1.4	0.2	-0.3	0.5	2.1	1.6
Hearing aid user	1.2	1.4	3.3	-1.7	1.8	-1.0	0.7	0.4	-1.0	-1.0
Irritability	1.2	2.0	4.5	1.3	2.1	1.1	0.8	2.1	-1.1	0.3
Risk taking	1.2	1.8	4.2	0.2	-0.1	1.5	0.4	1.8	1.5	2.0
Major Depression (MDD)	1.1	1.3	3.9	0.7	-0.1	-0.0	0.6	-1.4	-1.6	-2.0
Diabetes (mother)	1.1	1.4	2.4	0.5	0.7	1.5	0.7	1.3	1.5	1.6
Trunk fat percentage	1.1	4.3	10.0	-0.4	2.8	1.8	2.3	3.2	0.3	1.9
Townsend deprivation index at recruitment	1.1	1.6	3.1	-1.1	-0.2	-1.8	-0.1	-1.6	-1.4	-1.5
Maternal smoking around birth	1.1	1.5	3.5	0.9	1.8	0.5	0.9	1.9	0.8	1.2
Trunk fat mass	1.1	4.9	12.3	-0.2	3.5	1.7	2.7	3.2	-0.1	1.2
Falls in the last year	1.1	1.5	3.3	0.2	0.5	1.6	1.8	1.3	-1.5	-0.7
Forced vital capacity (FVC), Best measure	1.1	4.1	6.1	-1.9	-1.7	-2.4	-2.4	-1.9	-0.6	-2.5
Illnesses of father: High blood pressure	1.1	1.4	3.2	0.8	1.1	1.5	1.2	0.9	0.3	1.8
Crohns Disease (2012)	1.0	1.6	5.1	2.2	-0.1	1.9	0.9	0.7	-0.7	0.8
Fasting Glucose	1.0	1.1	3.5	1.9	1.0	0.8	1.3	0.6	0.9	-0.1
Current tobacco smoking	1.0	1.7	4.0	-0.1	1.7	-0.5	2.0	0.3	-1.5	-1.6
Pain all over the body in last month	1.0	1.1	3.6	-1.9	0.5	-1.2	0.2	-0.1	-1.3	-0.6
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	4.5	1.2	-0.1	0.7	0.7	0.8	2.1	1.3
Weight	1.0	4.8	14.1	0.4	3.8	1.7	2.7	2.9	-0.0	0.6
Medication: Cholesterol lowering	1.0	1.5	3.9	0.6	2.0	0.4	1.0	1.0	-1.5	-1.4
Pulse wave reflection index	1.0	1.2	4.3	0.8	-2.1	0.3	-1.1	-0.2	1.4	0.7
Medication: Gliclazide	1.0	1.1	1.9	1.0	1.2	1.3	1.4	1.1	0.7	0.3
Guilty feelings	1.0	1.5	4.7	-1.1	1.0	0.4	-0.3	1.0	-2.2	1.4
Unable to work because of sickness or disability	1.0	1.4	3.5	0.7	1.0	0.9	1.9	1.3	-1.3	0.5
Coronary Artery Disease (CAD)	0.9	1.1	2.7	1.6	0.9	0.7	1.5	0.6	-0.2	-0.9
Mean Putamen Volume	0.9	1.1	3.0	-1.7	1.0	-1.2	0.3	-0.4	-0.3	-1.3
Type 2 Diabetes (T2D) (2018)	0.9	1.6	5.9	1.4	2.4	1.1	1.4	-0.2	-0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.8	0.4	1.7	1.4	1.7	0.3	-0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	4.9	0.8	0.6	1.5	1.5	1.9	1.0	2.2
Stomach or abdominal pain in last month	0.9	1.2	4.0	1.0	-1.3	-0.5	-0.9	-0.7	2.0	0.1
Hearing difficulty/problems with background noise	0.9	1.4	3.2	-0.8	-0.5	-1.0	-0.7	1.4	1.4	1.8
Medication: Ramipril	0.9	1.2	3.8	1.2	1.9	1.0	1.2	0.7	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	5.7	-1.4	-1.1	-1.9	-2.1	-2.0	-0.4	-2.4
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.3	-0.2	1.3	-0.4	-0.1	-1.7	-1.8	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	5.1	-1.8	-0.9	-2.1	-1.8	-1.6	-0.7	-2.3
Breastfed as a baby	0.9	1.1	3.7	-0.8	-1.9	-0.5	-1.4	-0.5	0.3	-0.9
Blood clot in the leg (DVT)	0.9	1.1	2.7	0.7	0.3	1.6	1.0	1.2	0.7	1.3
High blood pressure (siblings)	0.9	1.3	3.4	1.9	0.7	1.4	1.3	0.8	0.6	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.4	0.6	-0.8	1.5	1.2	0.9	1.3	0.6
Number of full sisters	0.9	1.1	2.8	-0.5	1.0	0.8	-0.2	1.2	1.2	1.7
Diabetes diagnosed by doctor	0.9	1.4	5.9	0.9	2.4	0.7	1.2	0.5	-0.7	-0.6
Asthma (self-reported)	0.9	1.8	3.0	1.1	1.7	1.7	0.9	1.4	1.0	1.4
Osteoporosis (self-reported)	0.9	1.1	2.3	-0.7	1.1	-0.5	1.5	-0.3	-1.4	-1.2
Smoking status: Current	0.9	1.4	2.7	-0.1	1.5	-0.7	1.5	0.2	-1.4	-1.6
Fractured/broken bones in last 5 years	0.9	1.2	2.4	-0.9	-1.5	-0.2	-1.4	-0.5	1.5	0.8
Depression (Nagel 2018)	0.8	1.1	2.8	-0.7	1.3	0.7	0.9	1.2	-1.7	0.4
Multivitamins +/- minerals	0.8	1.0	3.0	0.6	0.6	-0.6	1.7	-0.9	-1.0	-1.1
Medication: Atenolol	0.8	1.0	3.0	1.0	0.8	1.2	0.8	1.7	-0.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.0	-1.4	1.0	-1.2	-0.4	-0.7	-0.9	-1.0
Heart attack	0.8	1.0	2.0	-1.2	-1.4	-0.3	-1.2	0.4	0.8	0.9
Asthma	0.8	1.6	2.8	1.0	1.7	1.5	0.8	1.3	1.2	1.3
Depression (self-reported)	0.8	0.9	3.9	0.3	0.8	0.9	0.9	2.0	0.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	5.1	-0.2	0.1	1.1	-1.0	2.3	-0.2	0.9
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.9	0.3	1.0	0.9	0.8	1.7	-1.1	0.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.3	-1.2	1.0	-1.5	0.0	-0.6	-1.0	-1.5
Medication: Paracetamol	0.8	1.4	4.0	-1.6	-0.0	-2.0	-0.5	-1.6	-0.5	0.1
Arm fat-free mass (right)	0.8	4.2	13.2	1.0	3.6	1.4	2.6	2.4	-0.7	-0.1
Exposure to tobacco smoke outside home	0.8	1.1	4.0	0.4	-1.7	0.4	-0.2	-0.3	0.4	2.0
Emphysema/chronic bronchitis	0.8	0.9	3.3	0.0	-1.8	0.4	-1.2	-0.5	-1.0	-0.2
Medication: Allopurinol	0.8	1.0	2.7	-0.0	1.0	0.8	0.6	1.5	0.4	1.7
Friendships satisfaction	0.8	1.0	3.1	0.5	1.0	0.3	1.0	-0.5	-1.8	-1.1
Qualifications: nursing, teaching	0.8	1.3	3.6	1.2	1.9	-0.2	-0.9	-0.3	-0.2	-1.7
Medication: Lisinopril	0.8	1.0	2.3	-0.1	0.6	0.8	1.5	1.2	0.8	1.3
Ever smoked	0.8	1.4	2.9	-0.0	-1.5	-0.7	-0.9	-1.5	-1.0	-1.7
Arm fat-free mass (left)	0.8	4.1	12.4	0.9	3.5	1.4	2.6	2.5	-0.5	0.1
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.5	-1.6	-1.5	-0.7	-1.4	0.1	0.4	0.5
Alcohol drinker status: Previous	0.8	0.9	3.4	0.1	1.2	0.6	0.4	0.8	-1.8	-0.7
Body Mass Index (BMI) (2010)	0.7	1.0	3.3	-1.1	1.1	-1.8	-0.8	-0.7	0.3	-0.2
Systolic Blood Pressure	0.7	3.5	7.6	2.8	1.8	2.0	2.6	0.5	-1.5	-0.5
Leg fat-free mass (left)	0.7	3.5	13.7	-0.1	3.7	0.8	2.3	1.9	-1.0	-0.5
Leg predicted mass (left)	0.7	3.5	13.9	-0.1	3.7	0.8	2.3	1.9	-1.0	-0.5
Nervous feelings	0.7	1.3	3.5	1.7	0.0	1.9	0.5	0.8	-0.6	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	3.0	0.7	1.1	1.5	1.2	1.7	0.7	1.7
Hip circumference	0.7	2.9	9.9	-0.5	3.1	1.1	1.7	2.5	-0.0	0.5
Pulse rate	0.7	1.1	3.2	0.3	0.3	1.2	0.3	1.8	1.1	1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.8	0.3	1.4	1.2	0.7	0.7	0.7	1.1
Health satisfaction	0.7	0.9	2.8	0.4	1.0	0.6	-0.5	-0.2	-1.7	-1.3
Arm predicted mass (right)	0.7	3.5	11.6	0.9	3.4	1.1	2.4	2.1	-0.7	-0.3
Age at last live birth	0.7	1.0	2.5	-1.6	0.5	-1.2	-0.6	-0.2	-1.2	-1.0
Osteoarthritis (self-reported)	0.7	0.9	3.0	-0.5	1.2	0.6	0.3	1.7	-1.0	-0.0
Average weekly champagne plus white wine intake	0.7	0.9	2.4	-1.0	-1.3	-0.4	-1.0	-1.6	0.5	-0.4
Ever taken oral contraceptive pill	0.7	0.7	2.1	0.3	-1.4	0.1	-1.1	-1.1	-0.2	-0.8
Supplements: Fish oil (including cod liver oil)	0.7	1.0	3.0	0.5	-1.3	0.2	-0.7	0.4	1.7	1.0
Basal metabolic rate	0.7	3.6	13.3	0.4	3.6	1.0	2.3	2.1	-0.8	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.0	0.5	0.2	1.4	0.9	0.9	0.7	1.3
Arm predicted mass (left)	0.7	3.7	11.1	0.9	3.3	1.3	2.5	2.4	-0.5	0.1
Intelligence (Savage-Jansen 2018)	0.6	1.9	7.3	0.6	2.7	0.3	2.1	0.3	-0.7	-0.5
Alzheimer’s Disease (including proxy)	0.6	0.8	2.4	-0.6	0.5	1.1	0.4	1.6	-0.3	1.1
Bipolar Disorder (2011)	0.6	0.5	1.9	0.2	-0.4	0.4	0.5	-1.0	-1.4	-0.5
Heel T-Score	0.6	4.9	6.9	2.3	2.6	2.3	2.6	1.9	1.5	2.1
Lung FVC	0.6	3.2	5.6	-2.3	-1.8	-2.3	-2.4	-1.0	0.6	-1.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.3	-1.0	0.9	0.5	-0.0	0.7	-1.8	-0.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.2	-1.1	0.7	-0.9	0.8	0.1	-1.0	-0.9
Medication for hormone replacement therapy	0.6	0.7	2.3	-0.5	-0.1	-0.8	-0.6	0.3	1.5	1.1
Neuroticism score	0.6	1.2	3.3	-0.2	0.8	0.7	-0.0	1.8	-1.8	0.8
Time employed in main current job	0.6	0.7	1.9	1.0	-1.4	-0.1	-0.2	-1.3	0.6	-0.4
Number of live births	0.6	0.8	1.5	-1.1	-1.0	-0.6	-1.2	-0.5	1.2	-0.2
Medication: Lansoprazole	0.6	0.6	1.5	-1.2	0.6	-0.8	-0.0	1.0	1.0	-0.0
Prospective memory result	0.6	0.7	2.3	0.1	-1.3	0.4	-0.5	0.4	-1.5	-0.7
Illnesses of mother	0.6	0.7	2.9	-0.5	-0.6	-0.7	-0.7	-0.8	-1.7	-0.5
Tense / ‘highly strung’	0.6	1.0	2.6	0.2	1.1	1.0	-0.2	1.6	-0.9	1.0
Glaucoma (self-reported)	0.6	0.7	1.9	0.4	1.4	0.5	0.7	0.7	-1.0	-0.6
Wheeze or whistling in the chest in last year	0.6	1.1	3.4	-0.2	0.2	1.2	0.9	1.3	-0.5	1.9
Neck or shoulder pain in last month	0.6	0.9	1.8	-1.0	-1.1	-0.9	-1.3	0.9	0.7	0.1
Suffer from ‘nerves’	0.6	1.0	1.9	1.4	-0.9	0.6	0.3	0.7	1.1	1.4
Family relationship satisfaction	0.6	0.7	2.2	-0.1	0.6	0.6	-0.6	-0.8	-1.5	-1.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.9	0.9	-0.6	0.8	0.7	0.7	1.4	0.3
Illnesses of siblings: Diabetes	0.6	0.8	1.6	0.4	1.3	1.0	1.0	0.6	-0.4	1.0
Leg fat-free mass (right)	0.6	3.2	11.4	-0.5	3.4	0.6	2.2	1.9	-1.2	-0.2
Average weekly red wine intake	0.6	0.9	1.7	-0.8	0.4	-0.5	-0.9	-1.2	-1.3	-1.0
Mineral and other dietary supplements	0.6	0.7	1.5	-0.6	0.8	-0.9	0.2	-1.2	-0.7	-1.2
Medication: Aspirin	0.6	0.8	3.2	1.8	-0.4	0.0	0.0	-0.7	0.0	-1.4
Leg predicted mass (right)	0.6	3.0	11.0	-0.5	3.3	0.6	2.2	1.9	-1.2	-0.3
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.2	0.9	1.0	0.6	1.1	1.1	0.7	0.8
Age started oral contraceptive pill	0.6	0.7	3.0	0.5	1.7	0.4	0.3	1.2	-0.4	0.2
Heart disease (siblings)	0.6	0.8	1.9	-0.9	1.4	0.5	1.1	0.8	-0.7	0.4
Neuroticism (Nagel 2018)	0.5	1.2	3.1	0.2	0.7	1.2	0.3	1.8	-1.3	1.2
Alzheimer’s Disease (in father)	0.5	0.5	1.5	-0.4	0.6	0.7	-0.6	1.2	-0.7	0.3
Breast Cancer	0.5	1.2	4.9	-1.3	0.5	-0.3	0.2	-0.9	-2.2	-0.4
Age at First Birth	0.5	0.7	1.6	0.2	1.0	0.7	0.3	1.3	-0.9	0.9
Hearing difficulty/problems: Yes	0.5	0.8	1.6	-0.4	-0.9	-0.8	-0.7	1.2	0.7	1.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.0	0.3	-0.2	-0.2	-0.3	0.3	1.4	1.4
Medication: Co-codamol	0.5	0.6	1.5	0.7	0.2	1.2	0.8	1.2	0.2	-0.1
Medication: Metformin	0.5	0.7	2.1	1.3	1.4	0.6	0.4	0.0	-0.5	-0.5
Relative age voice broke	0.5	0.7	3.3	0.3	0.6	-0.5	0.7	-0.0	-1.8	-0.7
Sitting height	0.5	3.6	9.0	-0.5	-2.1	-1.3	-2.5	-1.9	-0.3	-3.0
Chronic bronchitis/emphysema (father)	0.5	0.6	2.0	0.2	0.5	0.6	0.5	1.4	0.5	1.1
Past tobacco smoking	0.5	0.9	1.4	-0.9	1.2	-0.1	1.0	1.0	1.0	0.8
Diabetes (self-reported)	0.5	0.7	3.8	0.4	2.0	0.6	0.6	0.6	0.1	0.0
Father’s age at death	0.5	0.6	2.0	-0.4	-1.4	-1.0	-0.4	-0.5	0.1	-0.9
Exposure to tobacco smoke at home	0.5	0.6	1.9	-0.5	-0.0	0.0	0.9	-1.1	-1.4	0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.7	-1.2	0.7	-1.3	-0.1	0.3	-0.6	-0.1
Age at first live birth	0.5	1.0	2.1	0.2	1.3	0.8	-0.0	1.3	-1.4	-0.7
Overall health rating	0.5	1.0	3.3	0.9	1.8	0.3	1.1	1.1	-0.5	0.0
Had major operations	0.5	0.6	1.3	-1.1	-0.7	-0.7	-0.5	0.5	0.9	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	0.5	-1.1	0.1	0.5	-0.4	0.6	1.3
Medication: Aspirin	0.5	0.7	3.2	1.8	-0.4	0.3	0.1	-0.6	-0.2	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	1.0	-0.9	0.9	0.8	0.2	0.9	-0.5
Whole body fat-free mass	0.5	3.0	11.0	0.4	3.3	0.8	2.0	1.8	-0.9	-0.8
Loneliness, isolation	0.5	0.6	1.4	-1.1	-0.6	-0.6	-0.8	-0.5	-1.2	-0.5
Long-standing illness, disability or infirmity	0.5	0.8	1.8	1.1	1.3	1.3	-0.5	0.6	-0.2	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.2	-1.5	-0.3	-1.2	0.2	0.1	-0.3	-0.5
Whole body water mass	0.5	3.0	10.4	0.5	3.2	0.9	2.1	1.8	-1.0	-0.8
Eye problems/disorders: Glaucoma	0.5	0.6	1.2	0.8	0.8	1.1	0.8	0.9	-0.4	0.1
Ever depressed for a whole week	0.5	0.6	1.6	-1.3	-0.8	-0.3	-1.1	-0.0	-0.8	-0.5
Depressed Affect (Nagel 2018)	0.4	0.9	2.1	-0.5	0.9	0.8	0.6	1.4	-1.1	0.8
Crohns Disease (2017)	0.4	1.0	1.9	1.4	-0.0	1.2	-0.2	1.2	0.9	1.1
Irritable Bowel Disease (IBD)	0.4	0.9	2.9	1.7	0.6	0.8	0.5	1.0	1.1	0.5
HDL Cholesterol	0.4	0.7	2.6	-0.2	-1.6	-0.6	0.4	-0.2	0.8	0.8
Triglycerides	0.4	0.7	3.2	0.8	-0.1	1.8	-0.6	0.5	-0.6	0.1
Ulcerative Colitis	0.4	0.6	1.3	0.9	0.1	-0.6	0.6	-1.1	-0.4	-1.0
Hypothyroidism (self reported)	0.4	1.0	3.1	0.3	1.2	0.9	1.0	0.5	-1.8	-0.2
Respiratory disease	0.4	0.9	2.2	0.4	1.0	1.5	1.2	0.4	-0.4	1.1
Neuroticism	0.4	1.1	4.0	-0.3	0.6	0.7	0.3	1.6	-2.0	0.2
Vitamin and mineral supplements	0.4	0.5	1.8	0.5	-0.4	0.7	-1.3	0.3	0.6	0.7
Average weekly fortified wine intake	0.4	0.5	1.1	-0.0	1.1	-0.3	0.6	-0.5	-0.5	-1.0
Fed-up feelings	0.4	0.8	3.3	-0.9	0.0	-0.9	-0.4	-0.5	-1.8	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.6	-0.7	0.5	0.2	0.2	0.8	-1.6	0.1
High blood pressure (mother)	0.4	0.5	1.2	1.1	-0.4	1.0	-0.6	-0.7	0.4	-0.7
Qualifications: None of the above	0.4	0.8	2.4	-0.8	1.6	-0.1	1.0	1.0	-0.6	-0.5
Trunk fat-free mass	0.4	2.3	8.1	0.8	2.9	0.7	1.5	1.4	-0.8	-1.4
Trunk predicted mass	0.4	2.3	8.0	0.9	2.8	0.7	1.6	1.4	-0.8	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.4	-0.8	-0.9	0.3	-0.6	1.2	0.2	0.7
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	-0.9	0.9	0.8	0.6	1.1	-0.4	1.1
Supplements: Vitamin C	0.4	0.4	1.5	-0.8	0.3	-0.0	0.2	1.2	0.0	0.8
Mood swings	0.4	0.7	2.1	-0.2	1.0	0.4	0.2	1.2	-1.4	0.4
Commuting to job workplace: Walk	0.4	0.5	1.8	0.8	-0.8	0.4	-0.1	-1.3	-0.3	-0.0
Back pain experienced in last month	0.4	0.5	1.5	0.8	1.2	0.5	1.2	-0.0	0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.3	1.5	-0.5	-0.0	0.0	0.5	-0.5	-0.5
Commuting to job workplace: Public transport	0.4	0.5	1.1	-0.3	-1.0	-0.5	-0.4	-1.0	-0.5	-1.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.7	0.1	-1.3	0.2	-0.2	0.4	1.1	-0.2
Commuting to job workplace: Cycle	0.4	0.5	1.4	0.2	0.7	1.2	-0.8	0.9	0.4	0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-0.4	0.5	0.9	1.0	1.0	-0.5	0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	3.0	1.7	-0.6	0.6	0.8	0.1	1.0	0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	-0.9	-0.8	-0.1	-1.0	-0.3	-0.6	0.0
Worry (Nagel 2018)	0.3	0.7	1.8	1.3	-0.0	0.9	-0.0	1.3	0.2	0.6
Neuroticism (2016)	0.3	0.4	1.8	0.0	-0.5	-0.3	0.4	-0.0	-1.3	-0.5
Average weekly spirits intake	0.3	0.4	1.1	-0.7	1.1	-0.0	0.8	0.6	-0.2	0.3
Sensitivity / hurt feelings	0.3	0.5	1.2	-0.8	-0.1	-0.1	-0.9	1.1	-1.0	0.4
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	0.8	-0.6	0.5	0.5	-0.4	-0.3	0.6
Supplements: Zinc	0.3	0.4	0.9	-0.2	-0.1	-1.0	-0.5	-0.8	0.4	-0.6
Medication: Levothyroxine sodium	0.3	0.6	3.0	0.1	0.1	0.5	0.1	0.1	-1.7	-0.9
Alcohol usually taken with meals	0.3	0.4	2.1	0.4	0.7	-0.2	-0.2	0.2	1.4	0.3
Mouth/teeth dental problems	0.3	0.4	1.9	-0.6	0.1	-0.5	0.5	0.4	-0.1	-1.4
Allergy	0.3	0.7	1.2	-0.8	0.1	-0.9	-0.8	-0.8	-1.1	-1.0
Fluid intelligence score	0.3	0.5	1.0	0.7	0.9	0.5	1.0	-0.3	1.0	0.3
Standing height	0.3	3.2	9.1	-0.1	-1.9	-1.3	-2.2	-1.7	-0.4	-3.0
Birth weight of first child	0.3	0.6	1.8	0.2	-1.4	-0.2	-1.0	-1.0	-0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.4	0.6	0.4	0.7	-0.7	0.1	1.1
Headache pain in last month	0.3	0.6	1.7	-0.4	0.4	-1.3	0.5	-0.4	1.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.8	0.6	0.4	0.7	-0.2	-0.1	-1.7	-0.8
Number of full brothers	0.3	0.4	1.0	-1.0	-0.5	-0.6	0.9	-0.1	-0.5	-0.0
Medication: Seretide 50 evohaler	0.3	0.4	1.5	0.3	-0.4	0.0	-0.8	0.5	1.2	0.3
Mean time to correctly identify matches	0.3	0.6	2.0	0.3	-1.0	0.9	-1.4	0.5	0.2	0.2
Chest pain or discomfort	0.3	0.5	1.3	1.2	-0.7	0.2	-0.8	-0.4	0.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	2.2	1.5	-0.2	1.0	0.4	-0.0	0.1	-0.5
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.6	-0.2	1.3	-0.3	0.3	-0.4	-0.3	-0.8
Breast cancer (self-reported)	0.3	0.4	1.3	0.4	0.6	-0.2	0.4	1.1	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.5	-1.2	-0.3	-0.8	-0.0	0.4	0.9	0.8
Miserableness	0.3	0.5	3.0	-0.0	-0.1	-0.1	-0.4	-0.3	-1.7	-0.1
Pain experienced in last month	0.3	0.5	1.8	0.8	-0.6	1.3	0.4	0.7	0.2	0.6
Supplements: Calcium	0.3	0.3	0.8	0.9	-0.7	0.4	0.0	0.0	0.9	0.4
Basal cell carcinoma (self-reported)	0.3	0.3	1.3	0.5	-0.4	0.3	1.1	0.3	-0.6	0.0
Ulcerative Colitis (UC)	0.2	0.4	1.7	1.3	-0.0	-0.1	0.3	-0.0	1.1	-0.1
Reaction Time	0.2	0.3	1.1	0.3	-0.3	0.4	-0.8	-0.0	-1.1	-0.3
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.6	-0.8	1.3	-0.6	0.7	-0.1	1.0	0.0
Ovarian Cancer	0.2	0.3	0.9	-0.9	0.0	-0.1	0.1	0.3	0.1	0.9
LDL Cholesterol	0.2	0.3	1.4	0.1	0.6	0.4	-1.2	-0.2	-0.1	-0.5
Schizophrenia (2014)	0.2	0.4	1.3	1.1	0.2	0.5	0.8	0.3	0.3	-0.4
Blood White Count	0.2	1.7	4.0	0.9	1.3	1.1	2.0	1.8	0.0	1.0
Smoking Status	0.2	0.6	1.2	0.4	1.1	0.0	0.9	-0.0	-1.0	-1.0
Lung FEV1/FVC ratio	0.2	1.2	5.9	0.4	1.4	0.2	2.4	0.5	-0.1	0.4
Hand grip strength (left)	0.2	0.5	1.5	-0.7	0.2	-0.1	-0.3	0.0	1.2	1.1
Relative age of first facial hair	0.2	0.4	1.3	1.0	0.1	0.4	-0.0	-0.6	-1.1	-0.3
Hand grip strength (right)	0.2	0.6	1.8	-0.7	-0.3	-0.4	-0.9	-0.1	1.3	0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.0	0.1	0.3	0.3	0.7	0.4	0.3	1.0
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	0.4	0.6	0.9	0.5	-0.0	0.6	0.2
Had menopause	0.2	0.3	0.8	0.6	0.3	0.7	-0.1	0.9	-0.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.9	-0.8	0.4	-0.7	-0.4	-0.2	-1.0	-0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.4	-0.6	-0.3	-0.1	0.6	0.7	0.8
Happiness	0.2	0.2	0.7	0.3	0.4	0.8	-0.3	0.5	-0.2	-0.6
Qualifications: College or University degree	0.2	0.6	1.6	1.1	-0.6	0.2	-0.5	-1.3	-0.2	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.4	0.6	-0.1	-0.2	0.2	-0.0	-0.8
Pulse rate, automated reading	0.2	0.8	1.5	0.8	0.4	0.7	0.6	1.2	1.2	0.8
Alcohol intake frequency.	0.2	0.6	1.6	0.8	0.5	0.6	0.0	1.3	0.4	0.9
Comparative height size at age 10	0.2	1.0	2.5	1.4	-0.9	0.7	0.0	-0.4	-1.1	-1.6
Knee pain experienced in last month	0.2	0.4	1.1	-0.4	-0.2	0.2	-0.5	1.0	-0.1	1.0
Smoking status: Previous	0.2	0.4	0.7	0.6	-0.8	0.4	-0.9	-0.6	-0.3	0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.2	-0.7	-0.6	-0.8	-0.3	-0.4	0.1
Medication: Paracetamol	0.2	0.3	0.7	-0.8	0.4	-0.5	0.2	-0.2	-0.7	0.7
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.7	0.0	-0.1	-0.2	-0.9	0.3	-0.3	-0.2
Blood Eosinophil Count	0.1	0.7	2.1	1.4	-0.8	1.2	0.3	-0.9	-0.2	0.1
Blood Platelet Count	0.1	0.6	2.7	-1.6	0.4	-0.6	0.5	0.7	-0.1	0.6
Height	0.1	2.5	7.6	-0.4	-1.3	-1.5	-1.7	-1.3	-0.9	-2.8
Allergy or Eczema	0.1	0.4	1.3	0.4	0.4	0.4	1.1	0.7	-0.6	0.1
Chronotype (morning person)	0.1	0.2	0.7	-0.8	0.5	0.0	0.3	0.0	-0.8	0.3
Hair Pigment	0.1	1.7	6.6	-1.1	0.6	-2.6	-1.4	-1.0	0.4	-1.0
Tanning	0.1	0.8	2.2	0.2	1.0	1.1	1.5	0.9	-0.6	0.1
Angina	0.1	0.2	0.5	-0.4	0.4	0.0	-0.5	0.5	-0.7	0.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.6	-0.7	0.3	0.6	0.3	0.4	0.4
Supplements: Glucosamine	0.1	0.2	0.8	-0.1	-0.4	0.1	-0.3	0.0	-0.9	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.2	-0.2	-0.5	0.5	-0.3	-0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	0.1	0.5	0.3	0.1	0.8	-0.3	-0.1
Worrier / anxious feelings	0.1	0.2	0.4	0.1	0.4	-0.4	0.2	0.4	-0.7	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	0.1	-0.2	0.1	-0.2	0.2	0.3	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.2	-0.4	-0.3	0.1	-0.1	-0.5	0.1
Hair/balding pattern: Pattern 4	0.1	0.2	1.4	0.4	-0.0	0.1	0.3	0.2	-0.2	-1.2
Peak expiratory flow (PEF)	0.1	0.3	0.8	-0.8	0.5	-0.2	0.0	-0.3	0.9	-0.0
Birth weight	0.1	0.3	0.9	-0.2	-0.2	0.9	0.1	0.2	-0.8	-0.6
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.1	-0.3	-0.1	0.4	0.2	-0.5	-0.2
Angina (self-reported)	0.1	0.1	0.3	-0.4	0.1	-0.1	-0.5	0.5	-0.4	0.2
Medication: Ibuprofen	0.1	0.1	0.3	0.0	-0.2	0.2	-0.0	0.5	-0.4	-0.1
Medication: Omeprazole	0.1	0.1	0.5	0.1	0.4	0.7	0.3	0.1	-0.5	-0.0
Ever had bowel cancer screening	0.1	0.1	0.3	0.6	-0.1	0.4	0.1	0.6	-0.2	-0.2
Medication: Atorvastatin	0.1	0.2	0.8	0.4	-0.2	0.1	0.3	0.3	-0.1	-0.9
Schizophrenia (2018)	0.0	0.0	0.1	0.0	0.2	0.1	0.2	0.1	-0.1	-0.2

Hub : Genes

DYNC2H1

Models

Trait associations