Hub : Genes

ECI1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.179	0.0510	5.9e-05	0.128	NA	0.067	NA	0.108	8.4e-10	NA	9.5e-06	NA	1.9e-08
2	GTEx	Muscle Skeletal	0.145	0.0434	8.3e-05	0.109	NA	0.090	NA	0.100	8.5e-11	NA	3.5e-09	NA	4.8e-10
3	GTEx	Skin Sun Exposed Lower leg	0.154	0.0700	7.7e-03	0.070	NA	0.027	NA	0.035	1.9e-06	NA	2.3e-03	NA	6.7e-04
4	GTEx	Thyroid	0.110	0.0440	1.9e-03	-0.003	NA	0.016	NA	0.003	7.2e-01	NA	2.0e-02	NA	1.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	3.8	6.0	8.6	-2.7	-2.8	0.0	2.9
Bipolar Disorder or Schizophrenia	0.6	1.4	3.9	-0.9	-1.0	0.0	2.0
Depressed Affect (Nagel 2018)	0.4	0.8	1.9	-0.6	-1.4	-0.8	-0.6
Depression (Nagel 2018)	1.2	1.7	2.1	-1.4	-1.4	-1.2	1.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	-1.1	-0.6	-0.3	0.3
Neuroticism (Nagel 2018)	1.0	2.3	4.4	-1.4	-2.1	-1.7	-0.2
Schizophrenia (2018)	0.3	0.6	1.1	1.1	1.1	0.0	0.2
Schizophrenia vs Biploar Disorder	1.6	2.1	3.4	1.8	1.5	0.0	-1.7
Worry (Nagel 2018)	0.9	1.9	2.9	-1.3	-1.7	-1.7	0.3
Alzheimer’s Disease (in mother)	0.7	0.8	1.2	1.1	1.0	0.6	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	0.4	-0.6	-0.6	-0.3	0.6
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.1	0.2	0.1	-0.1
Crohns Disease (2017)	0.4	0.8	3.0	0.1	-0.2	0.5	-1.7
Irritable Bowel Disease (IBD)	0.3	0.6	0.8	-0.9	-0.9	-0.7	0.6
Ulcerative Colitis (UC)	1.0	2.0	5.9	-0.9	-0.6	-0.9	2.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.8	1.6	2.2	-1.4	-1.3	-1.5	-0.8
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.0	-1.7	-1.6	-1.1	1.2
Breast Cancer	0.1	0.2	0.4	0.0	-0.4	0.5	0.6
Ovarian Cancer	0.7	0.9	1.2	-0.8	-0.9	-1.1	0.9
Prostate Cancer	1.4	2.0	3.5	-1.1	-1.1	-1.5	1.9
Age at First Birth	0.3	0.5	1.0	0.6	1.0	0.4	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.4	0.7	1.0	0.5	-1.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.4	0.6	1.4	0.6	0.6	1.2	-0.5
Mean Putamen Volume	0.9	1.1	2.3	1.3	1.5	0.6	0.1
Fasting Glucose	0.7	0.9	1.7	-0.7	-0.8	-0.8	1.3
HbA1C	2.3	2.6	3.9	-1.6	-2.0	-1.3	1.4
HDL Cholesterol	0.0	0.1	0.1	0.2	0.3	0.2	-0.3
LDL Cholesterol	0.1	0.1	0.3	0.3	-0.1	-0.1	-0.5
Lupus	0.2	0.4	0.7	-0.7	-0.8	-0.1	-0.6
Neuroticism (2016)	0.2	0.3	0.5	0.7	0.2	0.6	-0.3
Primary Biliary Cirrhosis	0.1	0.2	0.4	0.4	0.3	0.6	-0.1
Rheumatoid Arthritis	0.7	1.0	3.9	0.2	0.1	0.0	-2.0
Schizophrenia (2014)	0.2	0.4	1.0	1.0	0.7	0.0	-0.3
Triglycerides	1.4	2.3	3.0	-1.2	-1.6	-1.5	1.7
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	1.0	1.4	4.7	-0.9	-0.5	0.0	2.2
Blood Eosinophil Count	0.4	3.4	11.6	0.8	0.7	1.1	-3.4
Blood Platelet Count	0.1	1.7	4.6	0.9	1.0	0.5	-2.1
Blood Red Count	0.1	0.6	1.4	0.4	1.2	0.8	-0.3
Blood White Count	1.3	9.8	24.7	2.3	2.2	2.1	-5.0
Heel T-Score	5.0	39.9	71.6	-5.3	-4.8	-6.1	8.5
BMI	0.3	1.9	4.5	1.2	0.8	1.0	-2.1
Height	4.2	80.0	240.2	5.5	2.7	6.5	-15.5
Waist Hip Ratio (WHR)	1.7	7.4	8.8	2.7	2.9	2.2	-3.0
Systolic Blood Pressure	0.6	2.8	4.0	-2.0	-1.8	-1.1	1.6
Smoking Status	0.4	1.0	2.5	-0.2	-1.2	0.0	-1.6
Allergy or Eczema	0.4	1.0	2.7	0.8	0.7	0.4	-1.6
Cardiovascular Disease	2.0	6.7	9.4	-3.1	-3.0	-2.8	0.7
Hypothyroidism (self reported)	1.0	2.2	8.0	0.6	0.2	0.6	-2.8
Respiratory disease	0.2	0.4	0.9	0.5	0.9	-0.0	-0.8
Type 2 Diabetes (T2D) (2018)	1.0	1.9	5.2	-0.6	-1.0	-1.0	2.3
Lung FEV1/FVC ratio	1.9	9.8	22.6	2.3	2.0	2.7	-4.7
Lung FVC	0.2	1.0	3.2	-0.7	-0.1	-0.7	1.8
Neuroticism	0.2	0.6	1.1	-0.6	-1.0	-0.8	-0.5
Chronotype (morning person)	0.2	0.5	1.4	-0.4	-0.1	-0.5	1.2
Hair Pigment	0.2	4.5	6.0	1.9	2.5	2.0	-2.0
Tanning	0.2	1.9	7.3	-0.2	-0.3	-0.2	2.7
Hand grip strength (left)	4.6	12.2	15.4	3.8	2.9	3.9	-3.2
Number of treatments/medications taken	0.6	1.1	1.3	-1.1	-1.1	-1.1	0.7
Average weekly spirits intake	0.7	0.9	2.8	-0.4	-0.8	0.1	-1.7
Sensitivity / hurt feelings	0.1	0.2	0.5	0.7	0.3	0.4	-0.3
Frequency of depressed mood in last 2 weeks	2.3	3.2	3.6	-1.9	-1.9	-1.8	1.6
Hearing difficulty/problems: Yes	2.0	3.0	4.1	-1.6	-1.8	-1.4	2.0
Relative age of first facial hair	0.1	0.2	0.5	0.4	0.2	0.2	0.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.6	-0.1	-0.0	0.2	-0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	-0.3	-0.1	-0.4	1.1
Ever had hysterectomy (womb removed)	1.9	2.2	3.2	1.8	1.7	1.6	-0.6
Systolic blood pressure, automated reading	0.1	0.3	0.5	-0.7	-0.6	-0.1	0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.2	0.5	0.2	0.9
Angina	2.2	2.9	4.1	-1.6	-2.0	-2.0	0.9
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.3
Vitamin and mineral supplements	0.3	0.3	1.0	0.4	0.4	-0.1	1.0
Supplements: Zinc	0.1	0.1	0.3	0.4	0.2	0.5	0.2
Medication: Co-codamol	0.1	0.1	0.4	-0.1	-0.0	-0.3	0.6
Medication: Metformin	0.5	0.8	1.0	0.9	1.0	0.8	0.8
Diabetes (father)	0.2	0.2	0.8	0.0	0.3	-0.4	0.9
Diabetes (mother)	1.6	2.0	3.7	1.9	1.4	1.5	0.5
Severe depression (siblings)	0.0	0.0	0.1	0.1	-0.3	0.1	-0.2
Pack years adult smoking proportion	0.0	0.0	0.1	0.1	-0.4	-0.1	0.1
Impedance of leg (right)	0.1	0.6	1.8	0.6	1.3	0.5	-0.1
Leg fat-free mass (left)	2.9	15.3	43.4	2.7	1.2	3.0	-6.6
Trunk fat percentage	0.8	3.1	3.9	1.8	1.5	1.6	-2.0
Hand grip strength (right)	1.7	4.6	5.7	2.2	1.6	2.4	-2.3
Townsend deprivation index at recruitment	0.1	0.2	0.4	0.4	0.6	0.4	-0.3
Current tobacco smoking	0.1	0.1	0.3	-0.0	-0.3	-0.5	-0.4
Average weekly fortified wine intake	0.3	0.3	0.7	-0.9	-0.3	-0.5	0.4
Maternal smoking around birth	0.7	1.0	1.7	-1.0	-1.3	-1.1	0.0
Fed-up feelings	0.6	1.1	2.3	-0.9	-1.5	-1.0	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	1.9	-1.3	-1.4	-1.3	1.3
Relative age voice broke	0.2	0.3	1.1	0.1	0.3	0.0	1.0
Taking other prescription medications	0.1	0.2	0.6	0.2	0.1	0.2	0.7
Age when periods started (menarche)	1.8	4.4	6.7	-2.0	-2.0	-1.6	2.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	0.5	0.5	0.4	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	4.6	10.4	20.4	-2.6	-2.3	-3.0	4.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	0.6	0.6	0.8	0.1
Qualifications: CSEs or equivalent	2.4	3.2	5.1	2.3	1.8	1.9	-1.0
Serious illness, injury or assault to yourself	0.5	0.7	1.2	0.8	0.5	0.7	-1.1
High blood pressure	1.8	5.0	6.4	-2.5	-2.5	-2.4	1.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.0	0.1	0.2	-0.1	-1.4
Multivitamins +/- minerals	0.2	0.2	0.4	-0.7	-0.6	-0.2	0.0
Stomach or abdominal pain in last month	1.3	1.6	1.9	-1.2	-1.0	-1.4	1.4
Supplements: Glucosamine	0.2	0.3	1.0	0.5	1.0	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.1	-0.8	-1.0	-1.1	-0.2
Medication: Atenolol	1.6	2.0	3.0	-1.2	-1.7	-1.2	-1.5
Medication: Levothyroxine sodium	0.3	0.5	1.1	0.8	0.4	0.3	-1.0
Sitting height	3.8	27.2	44.4	4.9	3.2	5.5	-6.7
Chronic bronchitis/emphysema (father)	1.5	1.7	4.3	-1.0	-0.5	-1.2	2.1
High blood pressure (mother)	0.1	0.1	0.5	0.0	-0.1	0.1	0.7
Body mass index (BMI)	0.1	0.5	1.0	0.7	0.2	0.5	-1.0
Impedance of leg (left)	0.1	0.7	1.9	0.7	1.4	0.6	0.1
Leg predicted mass (left)	2.8	15.0	42.9	2.7	1.2	2.9	-6.5
Trunk fat mass	1.9	8.4	18.7	2.5	1.7	2.4	-4.3
Waist circumference	2.5	9.0	21.6	2.4	1.8	2.4	-4.7
Number of incorrect matches in round	3.0	5.0	5.9	2.2	2.3	2.0	-2.4
Past tobacco smoking	0.9	1.7	2.9	-1.0	-0.1	-1.7	1.7
Alcohol usually taken with meals	1.1	1.9	2.2	1.2	1.3	1.4	-1.5
Nervous feelings	1.7	3.2	5.1	-1.6	-1.7	-2.3	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	3.7	-1.7	-1.9	-1.5	1.0
Hearing difficulty/problems with background noise	2.3	3.7	5.0	-2.2	-2.2	-1.7	1.4
Hair/balding pattern: Pattern 2	0.5	0.7	0.9	0.9	0.7	0.8	-1.0
Had menopause	1.0	1.2	1.8	1.1	1.3	1.3	0.0
Had other major operations	0.1	0.2	0.3	-0.3	-0.4	-0.5	-0.5
Forced vital capacity (FVC)	1.6	6.3	14.3	2.0	1.5	2.1	-3.8
Heel bone mineral density (BMD) T-score, automated (right)	3.7	8.4	13.5	-2.5	-2.3	-2.8	3.7
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	3.8	1.9	1.4	1.9	-1.9
Qualifications: None of the above	0.1	0.2	0.3	0.6	0.4	0.5	-0.2
Financial difficulties in last 2 years	0.1	0.1	0.3	0.5	0.3	0.1	-0.5
Mouth/teeth dental problems	1.2	1.8	1.9	1.4	1.3	1.4	-1.4
Heart attack	0.4	0.5	0.9	-0.6	-0.9	-0.6	0.7
Allergy	0.6	1.3	2.7	-0.9	-1.1	-0.6	1.6
Pain all over the body in last month	1.0	1.1	1.7	-1.0	-1.1	-0.5	1.3
Diabetes (self-reported)	0.5	0.8	3.1	-0.2	-0.3	-0.4	1.8
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	2.6	1.6	1.4	1.4	-0.7
Medication: Ramipril	1.9	2.4	3.8	-1.6	-1.9	-1.5	1.1
Medication: Simvastatin	0.3	0.5	1.1	-0.4	-0.8	-0.4	-1.1
Fluid intelligence score	0.8	1.7	3.0	-1.5	-0.9	-0.9	1.7
Illnesses of siblings	0.1	0.1	0.2	0.4	0.2	0.5	0.4
Neuroticism score	0.2	0.4	0.6	-0.5	-0.8	-0.6	0.5
Weight	3.3	16.1	41.6	3.1	1.8	3.2	-6.5
Impedance of arm (right)	0.2	1.0	2.9	0.3	1.1	-0.1	1.7
Arm fat percentage (right)	0.2	0.7	1.3	1.1	1.0	0.6	-0.4
Trunk fat-free mass	5.0	28.9	85.2	3.5	1.8	3.9	-9.2
Hip circumference	1.6	6.7	19.1	1.8	0.7	2.1	-4.4
Time employed in main current job	2.8	3.2	4.0	2.0	2.0	1.5	-1.6
Alcohol intake versus 10 years previously	1.1	1.7	5.4	0.7	0.7	0.6	-2.3
Father’s age at death	0.1	0.1	0.2	-0.3	-0.1	-0.3	0.5
Worrier / anxious feelings	2.6	4.8	6.3	-2.5	-2.5	-2.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	2.5	-1.6	-1.6	-1.5	0.8
Falls in the last year	0.9	1.3	4.8	0.5	-0.1	0.3	-2.2
Hair/balding pattern: Pattern 3	3.0	4.5	6.0	-2.3	-2.4	-2.4	0.9
Number of live births	2.5	3.6	7.6	1.4	1.7	1.3	2.8
Forced expiratory volume in 1-second (FEV1)	1.8	5.9	14.4	1.8	1.4	2.0	-3.8
Pulse rate	0.5	0.8	1.2	-1.1	-1.1	-0.8	0.4
Happiness	0.3	0.4	1.2	0.1	0.3	0.6	-1.1
Noisy workplace	0.5	0.6	1.6	-0.6	-1.3	-0.7	-0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	-0.6	-0.4	-0.5	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.0	0.8	1.0	0.6	-0.1
Mouth/teeth dental problems: Dentures	0.5	0.9	1.4	-0.7	-1.0	-0.8	1.2
Asthma	0.5	0.9	1.4	0.9	1.2	0.5	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.2	0.5	0.3	-0.2
Medication: Cholesterol lowering	0.2	0.3	1.0	0.1	-0.4	0.1	-1.0
Depression (self-reported)	4.4	5.2	6.5	-2.1	-2.4	-2.1	2.5
Medication: Lansoprazole	1.3	1.5	2.8	-0.9	-0.9	-1.3	1.7
Prospective memory result	0.8	0.9	1.5	1.0	0.7	0.9	-1.2
Lung cancer (father)	0.7	0.8	1.2	1.1	1.0	0.9	-0.2
Illnesses of mother	0.1	0.1	0.2	-0.4	-0.2	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.2	24.1	1.6	1.3	2.1	-4.9
Pulse wave Arterial Stiffness index	0.4	0.5	1.1	-0.8	-1.1	-0.5	0.1
Impedance of arm (left)	0.2	1.2	4.0	-0.3	0.5	-0.6	2.0
Arm fat mass (right)	1.1	4.4	10.2	1.8	1.1	1.6	-3.2
Trunk predicted mass	5.0	28.8	84.6	3.5	1.8	3.9	-9.2
Standing height	6.1	60.7	161.3	5.6	3.6	6.1	-12.7
Length of working week for main job	1.3	1.5	5.0	0.5	0.6	0.5	-2.2
Exposure to tobacco smoke at home	1.2	1.3	2.5	1.2	1.1	1.6	-0.4
Breastfed as a baby	1.2	1.4	2.7	-1.6	-1.1	-1.4	-0.1
Tense / ‘highly strung’	0.7	1.1	1.4	-1.1	-1.2	-1.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	1.1	0.6	0.6	0.2
Hair/balding pattern: Pattern 4	0.2	0.6	1.2	-0.6	-0.7	-0.4	1.1
Birth weight of first child	1.0	1.8	3.8	1.2	0.8	1.1	-1.9
Peak expiratory flow (PEF)	2.2	5.0	6.2	2.4	2.4	2.5	-1.5
Pulse wave reflection index	0.1	0.1	0.2	0.0	0.1	0.4	-0.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.0	-0.8	-0.8	-0.9	1.0
Loud music exposure frequency	1.7	1.8	2.8	-1.1	-1.6	-1.0	1.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	1.8	-1.3	-0.9	-1.1	1.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.1	0.2	-0.4	0.5
Blood clot in the leg (DVT)	1.7	2.2	2.6	1.5	1.6	1.6	-1.1
Medication: Paracetamol	0.2	0.4	0.8	0.6	0.4	0.9	-0.5
Headache pain in last month	0.2	0.4	0.8	-0.8	-0.3	-0.4	0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.2	0.7	1.1	0.8	0.6
Glaucoma (self-reported)	0.5	0.6	1.1	-0.9	-1.0	-0.7	0.0
Gout (self-reported)	0.4	0.6	1.0	-0.7	-1.0	-0.7	-0.6
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.6	0.6	0.2	0.4	-2.1
Medication: Amlodipine	0.1	0.2	0.3	-0.4	-0.4	-0.0	-0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.5	0.8	1.2	0.5	-0.1
Birth weight	4.8	10.5	19.7	3.0	2.5	2.6	-4.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.2	-0.9	-0.9	-1.1	0.8
High blood pressure (siblings)	0.2	0.2	0.3	-0.5	-0.4	-0.6	-0.3
Forced vital capacity (FVC), Best measure	2.1	7.8	20.6	1.8	1.5	2.2	-4.5
Body fat percentage	0.5	2.1	2.7	1.6	1.4	1.3	-1.4
Leg fat percentage (right)	0.3	0.9	1.3	1.0	1.0	0.7	-1.1
Arm fat-free mass (right)	4.4	22.5	68.1	2.9	1.4	3.4	-8.2
Exposure to tobacco smoke outside home	0.6	0.8	1.3	1.2	1.0	0.8	-0.3
Comparative body size at age 10	1.3	3.5	6.8	1.5	1.3	1.8	-2.6
Number of full brothers	0.0	0.1	0.1	-0.1	0.2	-0.2	0.4
Worry too long after embarrassment	0.7	1.1	1.8	-1.1	-0.5	-1.3	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.9	-0.3	-1.0	-0.5	0.2
Wheeze or whistling in the chest in last year	1.2	2.1	3.1	-1.3	-0.9	-1.8	1.7
Number of children fathered	5.0	5.7	8.1	-2.3	-1.7	-2.6	2.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.6	-0.8	-0.8	-1.3	1.1
Age at first live birth	1.2	2.2	3.8	-2.0	-1.2	-1.8	0.0
Pulse wave peak to peak time	0.8	1.0	1.4	1.1	1.2	0.8	-0.8
Health satisfaction	1.3	1.7	2.3	-1.5	-1.3	-1.4	0.9
Shortness of breath walking on level ground	1.1	1.3	1.9	-0.9	-1.4	-1.2	1.0
Qualifications: College or University degree	0.2	0.8	1.3	-0.9	-0.8	-0.6	1.1
Eye problems/disorders: None of the above	2.7	3.1	4.0	1.9	1.5	2.0	-1.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	-0.5	-0.3	-0.5	-0.5
Emphysema/chronic bronchitis	0.0	0.0	0.1	0.2	0.3	0.0	-0.3
Medication for pain relief, constipation, heartburn	0.5	0.8	1.2	1.1	1.1	1.0	0.1
Neck or shoulder pain in last month	0.1	0.2	0.4	0.1	0.3	0.4	0.7
Medication: Blood pressure	1.0	1.8	2.4	-1.4	-1.5	-1.4	0.9
Angina (self-reported)	2.0	2.6	3.6	-1.5	-1.8	-1.9	1.2
Migraine (self-reported)	0.5	0.6	1.8	-0.5	-0.3	-0.5	1.3
Medication: Ibuprofen	0.2	0.2	0.8	-0.1	-0.2	-0.0	-0.9
Medication: Allopurinol	0.6	0.9	1.4	1.2	1.0	1.0	0.2
Medication: Omeprazole	0.8	0.9	1.4	-1.2	-0.9	-1.1	0.3
Medication: Seretide 50 evohaler	0.1	0.2	0.3	0.1	0.5	-0.4	0.5
Mean time to correctly identify matches	0.7	1.4	2.1	-1.0	-1.1	-1.0	-1.5
Heart disease (mother)	0.1	0.2	0.5	0.0	0.3	-0.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.7	2.6	1.6	1.6	1.1	-0.8
Whole body fat mass	1.8	7.3	16.3	2.4	1.6	2.2	-4.0
Leg fat mass (right)	1.2	4.6	12.0	1.7	1.1	1.6	-3.5
Arm predicted mass (right)	4.2	21.7	64.2	3.0	1.5	3.4	-8.0
Pulse rate, automated reading	1.1	3.5	4.9	-2.2	-2.0	-2.0	1.0
Alcohol intake frequency.	0.1	0.3	0.5	-0.3	-0.4	-0.6	0.7
Comparative height size at age 10	8.8	48.4	108.2	5.7	4.0	6.0	-10.4
Number of full sisters	2.2	2.7	4.1	2.0	1.7	2.0	-0.1
Suffer from ‘nerves’	1.4	2.1	2.5	-1.4	-1.6	-1.4	1.4
Overall health rating	1.3	2.7	4.1	-1.9	-1.9	-2.0	0.1
Chest pain or discomfort	0.0	0.1	0.1	-0.3	-0.1	-0.3	0.1
Had major operations	0.1	0.1	0.3	0.1	-0.2	0.5	0.0
Age at last live birth	0.5	0.7	1.3	-1.1	-0.8	-1.0	0.0
Family relationship satisfaction	0.2	0.2	0.5	-0.5	-0.7	-0.1	-0.4
Leg pain on walking	0.5	0.7	1.0	-0.9	-1.0	-0.7	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	0.8	0.5	0.5	-0.0
Commuting to job workplace: Car/motor vehicle	1.1	1.3	4.4	0.0	0.6	-0.5	2.1
Illness, injury, bereavement, stress in last 2 years	4.3	5.2	7.1	-2.7	-2.5	-2.5	1.0
Medication: Aspirin	0.5	0.7	0.9	-0.6	-0.8	-0.8	1.0
Supplements: Vitamin C	1.0	1.2	1.8	1.0	1.1	1.4	-0.9
Knee pain experienced in last month	1.3	1.9	2.9	1.7	1.6	1.5	0.1
Hypertension (Self-reported)	1.7	4.7	6.6	-2.6	-2.5	-2.3	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	4.1	-1.6	-1.8	-2.0	-0.1
Illnesses of father: Heart disease	0.0	0.1	0.1	-0.3	0.1	0.1	-0.3
Illnesses of siblings: Diabetes	1.3	1.6	2.1	1.3	1.4	0.9	-1.3
Smoking status: Previous	1.1	1.7	3.8	0.8	-0.0	1.5	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	4.6	9.5	25.3	2.2	1.5	2.4	-5.0
Whole body fat-free mass	4.2	24.1	69.4	3.3	1.6	3.7	-8.3
Leg fat-free mass (right)	2.7	14.5	39.7	2.8	1.3	3.0	-6.3
Arm fat percentage (left)	0.1	0.3	0.6	0.8	0.6	0.3	-0.2
Average weekly red wine intake	0.3	0.4	0.6	-0.7	-0.7	-0.2	0.6
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.3	0.2	0.5	-0.4
Mood swings	0.4	0.7	1.2	-0.7	-1.1	-0.9	-0.4
Loneliness, isolation	0.1	0.2	0.3	-0.1	-0.5	-0.4	0.5
Long-standing illness, disability or infirmity	0.4	0.6	0.9	-0.6	-0.9	-0.8	0.8
Ever had bowel cancer screening	0.5	0.5	1.4	-0.4	-0.2	-0.7	1.2
Diabetes diagnosed by doctor	0.1	0.2	0.8	0.3	0.1	-0.0	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.5	-0.5	-0.3	-0.1
Friendships satisfaction	0.1	0.2	0.4	-0.1	0.1	0.4	0.7
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.6	-0.7	-0.7	0.3
Commuting to job workplace: Walk	0.6	0.6	1.2	0.9	0.3	1.1	-0.6
Eye problems/disorders: Cataract	1.3	1.5	1.9	-1.2	-1.4	-1.1	1.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.2	-0.4	0.2	-0.5	0.4
Medication for cholesterol	0.0	0.1	0.1	0.3	0.3	0.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	-0.8	-0.5	-0.5	-0.7
Back pain experienced in last month	3.1	4.5	5.5	-2.3	-1.9	-2.3	2.0
Mineral and other dietary supplements	0.0	0.1	0.1	-0.1	-0.1	-0.3	0.3
Breast cancer (self-reported)	0.4	0.5	1.1	-0.5	-0.4	-0.7	-1.1
Asthma (self-reported)	0.3	0.7	1.2	0.7	1.1	0.4	-1.0
Osteoporosis (self-reported)	0.6	0.7	1.7	0.7	1.3	0.8	0.1
Osteoarthritis (self-reported)	0.0	0.1	0.1	0.1	0.1	0.3	-0.3
Medication: Aspirin	0.1	0.2	0.3	-0.3	-0.4	-0.4	0.5
Medication: Gliclazide	1.4	1.5	2.7	1.6	1.3	1.1	-0.6
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	-0.5	-0.5	-0.4	-0.7
Smoking status: Current	0.1	0.1	0.2	0.0	-0.3	-0.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.6	4.3	1.4	2.1	1.4	-1.6
Whole body water mass	4.3	24.4	70.7	3.3	1.6	3.7	-8.4
Leg predicted mass (right)	2.6	14.1	38.7	2.7	1.2	2.9	-6.2
Arm fat mass (left)	0.9	3.9	9.1	1.7	1.0	1.6	-3.0
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	-0.4	-0.5	-0.4	0.5
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-0.7	-0.9	-0.7	-1.1
Miserableness	0.2	0.4	0.6	-0.2	-0.8	-0.6	0.6
Guilty feelings	0.4	0.6	0.9	-0.9	-0.8	-0.4	0.9
Wears glasses or contact lenses	0.1	0.1	0.4	0.3	0.6	0.0	0.0
Ever taken oral contraceptive pill	3.0	3.4	5.4	-1.6	-1.8	-1.6	2.3
Hearing aid user	0.3	0.3	0.6	0.6	0.3	0.8	-0.4
Mother’s age at death	0.8	1.0	3.8	-0.3	-0.1	-0.5	1.9
Financial situation satisfaction	1.5	1.8	2.1	-1.4	-1.3	-1.4	1.3
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.4	-0.6	-0.6	-0.1	-0.6
Commuting to job workplace: Public transport	1.0	1.2	4.7	0.3	0.1	0.3	-2.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.7	-0.8	-0.4	1.1
Medication: Blood pressure	0.0	0.1	0.1	-0.2	-0.4	0.1	0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.2	0.5	0.1	0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	0.7	0.7	1.0	-0.4
High cholesterol (Self-reported)	0.3	0.6	0.7	-0.8	-0.8	-0.6	-0.8
Medication: Bendroflumethiazide	1.3	2.0	3.1	-1.5	-1.8	-1.6	-0.3
Medication: Paracetamol	0.1	0.2	0.3	-0.5	-0.5	-0.3	0.4
Medication: Lisinopril	0.8	1.0	1.6	-1.3	-1.0	-1.0	0.5
Medication: Atorvastatin	1.2	1.5	4.8	0.4	0.9	0.3	2.2
Illnesses of father: High blood pressure	0.6	0.8	1.1	1.0	1.1	0.8	-0.5
Alcohol drinker status: Never	1.8	2.2	3.1	-1.7	-1.8	-1.6	-0.3
Ever smoked	1.2	2.1	3.5	1.1	0.5	1.9	-1.9
Basal metabolic rate	4.1	22.8	64.0	3.3	1.7	3.6	-8.0
Leg fat percentage (left)	0.2	0.9	1.1	1.0	1.0	0.7	-1.0
Arm fat-free mass (left)	4.4	22.1	63.0	3.1	1.6	3.6	-7.9
Number of operations (self-reported)	0.2	0.3	0.5	-0.6	-0.7	-0.3	0.2
Average weekly beer plus cider intake	0.0	0.0	0.1	0.2	0.1	0.1	0.2
Irritability	0.7	1.1	2.0	-0.9	-1.4	-1.0	-0.8
Risk taking	0.1	0.1	0.3	-0.4	-0.5	0.1	-0.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.1	-1.0	-0.8	-1.1	-0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.9	-0.0	-0.4	0.1	-0.9
Age started oral contraceptive pill	0.2	0.3	0.4	-0.6	-0.6	-0.7	-0.2
Diastolic blood pressure, automated reading	0.1	0.3	0.7	-0.8	-0.7	-0.4	0.2
Ever depressed for a whole week	0.3	0.3	1.2	0.0	-0.1	0.0	-1.1
Unable to work because of sickness or disability	0.1	0.2	0.7	-0.2	-0.8	0.0	0.1
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.1	-0.3	0.0	-0.1
Myopia	1.1	1.6	2.5	1.6	1.4	1.4	-0.5
Vascular/heart problems diagnosed by doctor	1.8	5.0	6.5	2.5	2.6	2.4	-1.3
Cholesterol lowering medication	0.2	0.3	1.1	-0.3	-0.2	-0.1	1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.3	-1.0	-0.7	-1.2	0.6
Pain experienced in last month	2.2	3.7	6.1	2.0	1.4	1.7	-2.5
Supplements: Calcium	0.3	0.3	0.7	0.3	0.3	0.8	0.6
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	0.6	0.9	0.5	-0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	-0.6	-0.9	-0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	4.0	2.0	2.0	2.0	-1.5
Heart disease (siblings)	0.2	0.3	0.8	-0.2	-0.5	-0.1	-0.9
Alcohol drinker status: Previous	0.2	0.2	0.8	0.2	0.1	0.1	0.9
Pack years of smoking	0.0	0.0	0.1	0.1	-0.4	-0.0	-0.0
Impedance of whole body	0.2	1.0	2.9	0.1	0.9	-0.2	1.7
Leg fat mass (left)	1.3	5.0	12.7	1.8	1.1	1.6	-3.6
Arm predicted mass (left)	4.5	23.0	66.4	3.2	1.7	3.5	-8.2