Hub : Genes

ECI1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.179 0.0510 5.9e-05 0.128 NA 0.067 NA 0.108 8.4e-10 NA 9.5e-06 NA 1.9e-08
2 GTEx Muscle Skeletal 0.145 0.0434 8.3e-05 0.109 NA 0.090 NA 0.100 8.5e-11 NA 3.5e-09 NA 4.8e-10
3 GTEx Skin Sun Exposed Lower leg 0.154 0.0700 7.7e-03 0.070 NA 0.027 NA 0.035 1.9e-06 NA 2.3e-03 NA 6.7e-04
4 GTEx Thyroid 0.110 0.0440 1.9e-03 -0.003 NA 0.016 NA 0.003 7.2e-01 NA 2.0e-02 NA 1.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 3.8 6.0 8.6 -2.7 -2.8 0.0 2.9
Bipolar Disorder or Schizophrenia 0.6 1.4 3.9 -0.9 -1.0 0.0 2.0
Depressed Affect (Nagel 2018) 0.4 0.8 1.9 -0.6 -1.4 -0.8 -0.6
Depression (Nagel 2018) 1.2 1.7 2.1 -1.4 -1.4 -1.2 1.2
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.1 -1.1 -0.6 -0.3 0.3
Neuroticism (Nagel 2018) 1.0 2.3 4.4 -1.4 -2.1 -1.7 -0.2
Schizophrenia (2018) 0.3 0.6 1.1 1.1 1.1 0.0 0.2
Schizophrenia vs Biploar Disorder 1.6 2.1 3.4 1.8 1.5 0.0 -1.7
Worry (Nagel 2018) 0.9 1.9 2.9 -1.3 -1.7 -1.7 0.3
Alzheimer’s Disease (in mother) 0.7 0.8 1.2 1.1 1.0 0.6 -0.7
Alzheimer’s Disease (in father) 0.3 0.3 0.4 -0.6 -0.6 -0.3 0.6
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 0.1 0.2 0.1 -0.1
Crohns Disease (2017) 0.4 0.8 3.0 0.1 -0.2 0.5 -1.7
Irritable Bowel Disease (IBD) 0.3 0.6 0.8 -0.9 -0.9 -0.7 0.6
Ulcerative Colitis (UC) 1.0 2.0 5.9 -0.9 -0.6 -0.9 2.4
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.8 1.6 2.2 -1.4 -1.3 -1.5 -0.8
Verbal and Numeric Reasoning (VNR) 0.8 2.0 3.0 -1.7 -1.6 -1.1 1.2
Breast Cancer 0.1 0.2 0.4 0.0 -0.4 0.5 0.6
Ovarian Cancer 0.7 0.9 1.2 -0.8 -0.9 -1.1 0.9
Prostate Cancer 1.4 2.0 3.5 -1.1 -1.1 -1.5 1.9
Age at First Birth 0.3 0.5 1.0 0.6 1.0 0.4 -0.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 1.4 0.7 1.0 0.5 -1.2
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.4 0.6 1.4 0.6 0.6 1.2 -0.5
Mean Putamen Volume 0.9 1.1 2.3 1.3 1.5 0.6 0.1
Fasting Glucose 0.7 0.9 1.7 -0.7 -0.8 -0.8 1.3
HbA1C 2.3 2.6 3.9 -1.6 -2.0 -1.3 1.4
HDL Cholesterol 0.0 0.1 0.1 0.2 0.3 0.2 -0.3
LDL Cholesterol 0.1 0.1 0.3 0.3 -0.1 -0.1 -0.5
Lupus 0.2 0.4 0.7 -0.7 -0.8 -0.1 -0.6
Neuroticism (2016) 0.2 0.3 0.5 0.7 0.2 0.6 -0.3
Primary Biliary Cirrhosis 0.1 0.2 0.4 0.4 0.3 0.6 -0.1
Rheumatoid Arthritis 0.7 1.0 3.9 0.2 0.1 0.0 -2.0
Schizophrenia (2014) 0.2 0.4 1.0 1.0 0.7 0.0 -0.3
Triglycerides 1.4 2.3 3.0 -1.2 -1.6 -1.5 1.7
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 1.0 1.4 4.7 -0.9 -0.5 0.0 2.2
Blood Eosinophil Count 0.4 3.4 11.6 0.8 0.7 1.1 -3.4
Blood Platelet Count 0.1 1.7 4.6 0.9 1.0 0.5 -2.1
Blood Red Count 0.1 0.6 1.4 0.4 1.2 0.8 -0.3
Blood White Count 1.3 9.8 24.7 2.3 2.2 2.1 -5.0
Heel T-Score 5.0 39.9 71.6 -5.3 -4.8 -6.1 8.5
BMI 0.3 1.9 4.5 1.2 0.8 1.0 -2.1
Height 4.2 80.0 240.2 5.5 2.7 6.5 -15.5
Waist Hip Ratio (WHR) 1.7 7.4 8.8 2.7 2.9 2.2 -3.0
Systolic Blood Pressure 0.6 2.8 4.0 -2.0 -1.8 -1.1 1.6
Smoking Status 0.4 1.0 2.5 -0.2 -1.2 0.0 -1.6
Allergy or Eczema 0.4 1.0 2.7 0.8 0.7 0.4 -1.6
Cardiovascular Disease 2.0 6.7 9.4 -3.1 -3.0 -2.8 0.7
Hypothyroidism (self reported) 1.0 2.2 8.0 0.6 0.2 0.6 -2.8
Respiratory disease 0.2 0.4 0.9 0.5 0.9 -0.0 -0.8
Type 2 Diabetes (T2D) (2018) 1.0 1.9 5.2 -0.6 -1.0 -1.0 2.3
Lung FEV1/FVC ratio 1.9 9.8 22.6 2.3 2.0 2.7 -4.7
Lung FVC 0.2 1.0 3.2 -0.7 -0.1 -0.7 1.8
Neuroticism 0.2 0.6 1.1 -0.6 -1.0 -0.8 -0.5
Chronotype (morning person) 0.2 0.5 1.4 -0.4 -0.1 -0.5 1.2
Hair Pigment 0.2 4.5 6.0 1.9 2.5 2.0 -2.0
Tanning 0.2 1.9 7.3 -0.2 -0.3 -0.2 2.7
Hand grip strength (left) 4.6 12.2 15.4 3.8 2.9 3.9 -3.2
Number of treatments/medications taken 0.6 1.1 1.3 -1.1 -1.1 -1.1 0.7
Average weekly spirits intake 0.7 0.9 2.8 -0.4 -0.8 0.1 -1.7
Sensitivity / hurt feelings 0.1 0.2 0.5 0.7 0.3 0.4 -0.3
Frequency of depressed mood in last 2 weeks 2.3 3.2 3.6 -1.9 -1.9 -1.8 1.6
Hearing difficulty/problems: Yes 2.0 3.0 4.1 -1.6 -1.8 -1.4 2.0
Relative age of first facial hair 0.1 0.2 0.5 0.4 0.2 0.2 0.7
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.6 -0.1 -0.0 0.2 -0.8
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.2 -0.3 -0.1 -0.4 1.1
Ever had hysterectomy (womb removed) 1.9 2.2 3.2 1.8 1.7 1.6 -0.6
Systolic blood pressure, automated reading 0.1 0.3 0.5 -0.7 -0.6 -0.1 0.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.7 0.2 0.5 0.2 0.9
Angina 2.2 2.9 4.1 -1.6 -2.0 -2.0 0.9
Medication for hormone replacement therapy 0.0 0.0 0.1 -0.1 0.2 -0.1 -0.3
Vitamin and mineral supplements 0.3 0.3 1.0 0.4 0.4 -0.1 1.0
Supplements: Zinc 0.1 0.1 0.3 0.4 0.2 0.5 0.2
Medication: Co-codamol 0.1 0.1 0.4 -0.1 -0.0 -0.3 0.6
Medication: Metformin 0.5 0.8 1.0 0.9 1.0 0.8 0.8
Diabetes (father) 0.2 0.2 0.8 0.0 0.3 -0.4 0.9
Diabetes (mother) 1.6 2.0 3.7 1.9 1.4 1.5 0.5
Severe depression (siblings) 0.0 0.0 0.1 0.1 -0.3 0.1 -0.2
Pack years adult smoking proportion 0.0 0.0 0.1 0.1 -0.4 -0.1 0.1
Impedance of leg (right) 0.1 0.6 1.8 0.6 1.3 0.5 -0.1
Leg fat-free mass (left) 2.9 15.3 43.4 2.7 1.2 3.0 -6.6
Trunk fat percentage 0.8 3.1 3.9 1.8 1.5 1.6 -2.0
Hand grip strength (right) 1.7 4.6 5.7 2.2 1.6 2.4 -2.3
Townsend deprivation index at recruitment 0.1 0.2 0.4 0.4 0.6 0.4 -0.3
Current tobacco smoking 0.1 0.1 0.3 -0.0 -0.3 -0.5 -0.4
Average weekly fortified wine intake 0.3 0.3 0.7 -0.9 -0.3 -0.5 0.4
Maternal smoking around birth 0.7 1.0 1.7 -1.0 -1.3 -1.1 0.0
Fed-up feelings 0.6 1.1 2.3 -0.9 -1.5 -1.0 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 1.9 -1.3 -1.4 -1.3 1.3
Relative age voice broke 0.2 0.3 1.1 0.1 0.3 0.0 1.0
Taking other prescription medications 0.1 0.2 0.6 0.2 0.1 0.2 0.7
Age when periods started (menarche) 1.8 4.4 6.7 -2.0 -2.0 -1.6 2.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.3 0.5 0.5 0.4 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 4.6 10.4 20.4 -2.6 -2.3 -3.0 4.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 0.6 0.6 0.8 0.1
Qualifications: CSEs or equivalent 2.4 3.2 5.1 2.3 1.8 1.9 -1.0
Serious illness, injury or assault to yourself 0.5 0.7 1.2 0.8 0.5 0.7 -1.1
High blood pressure 1.8 5.0 6.4 -2.5 -2.5 -2.4 1.3
Hayfever, allergic rhinitis or eczema 0.2 0.5 2.0 0.1 0.2 -0.1 -1.4
Multivitamins +/- minerals 0.2 0.2 0.4 -0.7 -0.6 -0.2 0.0
Stomach or abdominal pain in last month 1.3 1.6 1.9 -1.2 -1.0 -1.4 1.4
Supplements: Glucosamine 0.2 0.3 1.0 0.5 1.0 0.2 0.1
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.1 -0.8 -1.0 -1.1 -0.2
Medication: Atenolol 1.6 2.0 3.0 -1.2 -1.7 -1.2 -1.5
Medication: Levothyroxine sodium 0.3 0.5 1.1 0.8 0.4 0.3 -1.0
Sitting height 3.8 27.2 44.4 4.9 3.2 5.5 -6.7
Chronic bronchitis/emphysema (father) 1.5 1.7 4.3 -1.0 -0.5 -1.2 2.1
High blood pressure (mother) 0.1 0.1 0.5 0.0 -0.1 0.1 0.7
Body mass index (BMI) 0.1 0.5 1.0 0.7 0.2 0.5 -1.0
Impedance of leg (left) 0.1 0.7 1.9 0.7 1.4 0.6 0.1
Leg predicted mass (left) 2.8 15.0 42.9 2.7 1.2 2.9 -6.5
Trunk fat mass 1.9 8.4 18.7 2.5 1.7 2.4 -4.3
Waist circumference 2.5 9.0 21.6 2.4 1.8 2.4 -4.7
Number of incorrect matches in round 3.0 5.0 5.9 2.2 2.3 2.0 -2.4
Past tobacco smoking 0.9 1.7 2.9 -1.0 -0.1 -1.7 1.7
Alcohol usually taken with meals 1.1 1.9 2.2 1.2 1.3 1.4 -1.5
Nervous feelings 1.7 3.2 5.1 -1.6 -1.7 -2.3 1.5
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 3.7 -1.7 -1.9 -1.5 1.0
Hearing difficulty/problems with background noise 2.3 3.7 5.0 -2.2 -2.2 -1.7 1.4
Hair/balding pattern: Pattern 2 0.5 0.7 0.9 0.9 0.7 0.8 -1.0
Had menopause 1.0 1.2 1.8 1.1 1.3 1.3 0.0
Had other major operations 0.1 0.2 0.3 -0.3 -0.4 -0.5 -0.5
Forced vital capacity (FVC) 1.6 6.3 14.3 2.0 1.5 2.1 -3.8
Heel bone mineral density (BMD) T-score, automated (right) 3.7 8.4 13.5 -2.5 -2.3 -2.8 3.7
Ever unenthusiastic/disinterested for a whole week 2.6 3.2 3.8 1.9 1.4 1.9 -1.9
Qualifications: None of the above 0.1 0.2 0.3 0.6 0.4 0.5 -0.2
Financial difficulties in last 2 years 0.1 0.1 0.3 0.5 0.3 0.1 -0.5
Mouth/teeth dental problems 1.2 1.8 1.9 1.4 1.3 1.4 -1.4
Heart attack 0.4 0.5 0.9 -0.6 -0.9 -0.6 0.7
Allergy 0.6 1.3 2.7 -0.9 -1.1 -0.6 1.6
Pain all over the body in last month 1.0 1.1 1.7 -1.0 -1.1 -0.5 1.3
Diabetes (self-reported) 0.5 0.8 3.1 -0.2 -0.3 -0.4 1.8
Hayfever/allergic rhinitis (self-reported) 1.3 1.8 2.6 1.6 1.4 1.4 -0.7
Medication: Ramipril 1.9 2.4 3.8 -1.6 -1.9 -1.5 1.1
Medication: Simvastatin 0.3 0.5 1.1 -0.4 -0.8 -0.4 -1.1
Fluid intelligence score 0.8 1.7 3.0 -1.5 -0.9 -0.9 1.7
Illnesses of siblings 0.1 0.1 0.2 0.4 0.2 0.5 0.4
Neuroticism score 0.2 0.4 0.6 -0.5 -0.8 -0.6 0.5
Weight 3.3 16.1 41.6 3.1 1.8 3.2 -6.5
Impedance of arm (right) 0.2 1.0 2.9 0.3 1.1 -0.1 1.7
Arm fat percentage (right) 0.2 0.7 1.3 1.1 1.0 0.6 -0.4
Trunk fat-free mass 5.0 28.9 85.2 3.5 1.8 3.9 -9.2
Hip circumference 1.6 6.7 19.1 1.8 0.7 2.1 -4.4
Time employed in main current job 2.8 3.2 4.0 2.0 2.0 1.5 -1.6
Alcohol intake versus 10 years previously 1.1 1.7 5.4 0.7 0.7 0.6 -2.3
Father’s age at death 0.1 0.1 0.2 -0.3 -0.1 -0.3 0.5
Worrier / anxious feelings 2.6 4.8 6.3 -2.5 -2.5 -2.3 1.2
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 2.5 -1.6 -1.6 -1.5 0.8
Falls in the last year 0.9 1.3 4.8 0.5 -0.1 0.3 -2.2
Hair/balding pattern: Pattern 3 3.0 4.5 6.0 -2.3 -2.4 -2.4 0.9
Number of live births 2.5 3.6 7.6 1.4 1.7 1.3 2.8
Forced expiratory volume in 1-second (FEV1) 1.8 5.9 14.4 1.8 1.4 2.0 -3.8
Pulse rate 0.5 0.8 1.2 -1.1 -1.1 -0.8 0.4
Happiness 0.3 0.4 1.2 0.1 0.3 0.6 -1.1
Noisy workplace 0.5 0.6 1.6 -0.6 -1.3 -0.7 -0.0
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.5 -0.6 -0.4 -0.5 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.0 0.8 1.0 0.6 -0.1
Mouth/teeth dental problems: Dentures 0.5 0.9 1.4 -0.7 -1.0 -0.8 1.2
Asthma 0.5 0.9 1.4 0.9 1.2 0.5 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.2 0.5 0.3 -0.2
Medication: Cholesterol lowering 0.2 0.3 1.0 0.1 -0.4 0.1 -1.0
Depression (self-reported) 4.4 5.2 6.5 -2.1 -2.4 -2.1 2.5
Medication: Lansoprazole 1.3 1.5 2.8 -0.9 -0.9 -1.3 1.7
Prospective memory result 0.8 0.9 1.5 1.0 0.7 0.9 -1.2
Lung cancer (father) 0.7 0.8 1.2 1.1 1.0 0.9 -0.2
Illnesses of mother 0.1 0.1 0.2 -0.4 -0.2 -0.3 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.6 8.2 24.1 1.6 1.3 2.1 -4.9
Pulse wave Arterial Stiffness index 0.4 0.5 1.1 -0.8 -1.1 -0.5 0.1
Impedance of arm (left) 0.2 1.2 4.0 -0.3 0.5 -0.6 2.0
Arm fat mass (right) 1.1 4.4 10.2 1.8 1.1 1.6 -3.2
Trunk predicted mass 5.0 28.8 84.6 3.5 1.8 3.9 -9.2
Standing height 6.1 60.7 161.3 5.6 3.6 6.1 -12.7
Length of working week for main job 1.3 1.5 5.0 0.5 0.6 0.5 -2.2
Exposure to tobacco smoke at home 1.2 1.3 2.5 1.2 1.1 1.6 -0.4
Breastfed as a baby 1.2 1.4 2.7 -1.6 -1.1 -1.4 -0.1
Tense / ‘highly strung’ 0.7 1.1 1.4 -1.1 -1.2 -1.1 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.1 1.1 0.6 0.6 0.2
Hair/balding pattern: Pattern 4 0.2 0.6 1.2 -0.6 -0.7 -0.4 1.1
Birth weight of first child 1.0 1.8 3.8 1.2 0.8 1.1 -1.9
Peak expiratory flow (PEF) 2.2 5.0 6.2 2.4 2.4 2.5 -1.5
Pulse wave reflection index 0.1 0.1 0.2 0.0 0.1 0.4 -0.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.0 -0.8 -0.8 -0.9 1.0
Loud music exposure frequency 1.7 1.8 2.8 -1.1 -1.6 -1.0 1.7
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 1.8 -1.3 -0.9 -1.1 1.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.2 0.1 0.2 -0.4 0.5
Blood clot in the leg (DVT) 1.7 2.2 2.6 1.5 1.6 1.6 -1.1
Medication: Paracetamol 0.2 0.4 0.8 0.6 0.4 0.9 -0.5
Headache pain in last month 0.2 0.4 0.8 -0.8 -0.3 -0.4 0.9
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.2 0.7 1.1 0.8 0.6
Glaucoma (self-reported) 0.5 0.6 1.1 -0.9 -1.0 -0.7 0.0
Gout (self-reported) 0.4 0.6 1.0 -0.7 -1.0 -0.7 -0.6
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 4.6 0.6 0.2 0.4 -2.1
Medication: Amlodipine 0.1 0.2 0.3 -0.4 -0.4 -0.0 -0.6
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.5 0.8 1.2 0.5 -0.1
Birth weight 4.8 10.5 19.7 3.0 2.5 2.6 -4.4
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.2 -0.9 -0.9 -1.1 0.8
High blood pressure (siblings) 0.2 0.2 0.3 -0.5 -0.4 -0.6 -0.3
Forced vital capacity (FVC), Best measure 2.1 7.8 20.6 1.8 1.5 2.2 -4.5
Body fat percentage 0.5 2.1 2.7 1.6 1.4 1.3 -1.4
Leg fat percentage (right) 0.3 0.9 1.3 1.0 1.0 0.7 -1.1
Arm fat-free mass (right) 4.4 22.5 68.1 2.9 1.4 3.4 -8.2
Exposure to tobacco smoke outside home 0.6 0.8 1.3 1.2 1.0 0.8 -0.3
Comparative body size at age 10 1.3 3.5 6.8 1.5 1.3 1.8 -2.6
Number of full brothers 0.0 0.1 0.1 -0.1 0.2 -0.2 0.4
Worry too long after embarrassment 0.7 1.1 1.8 -1.1 -0.5 -1.3 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 0.9 -0.3 -1.0 -0.5 0.2
Wheeze or whistling in the chest in last year 1.2 2.1 3.1 -1.3 -0.9 -1.8 1.7
Number of children fathered 5.0 5.7 8.1 -2.3 -1.7 -2.6 2.8
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.6 -0.8 -0.8 -1.3 1.1
Age at first live birth 1.2 2.2 3.8 -2.0 -1.2 -1.8 0.0
Pulse wave peak to peak time 0.8 1.0 1.4 1.1 1.2 0.8 -0.8
Health satisfaction 1.3 1.7 2.3 -1.5 -1.3 -1.4 0.9
Shortness of breath walking on level ground 1.1 1.3 1.9 -0.9 -1.4 -1.2 1.0
Qualifications: College or University degree 0.2 0.8 1.3 -0.9 -0.8 -0.6 1.1
Eye problems/disorders: None of the above 2.7 3.1 4.0 1.9 1.5 2.0 -1.5
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.3 -0.5 -0.3 -0.5 -0.5
Emphysema/chronic bronchitis 0.0 0.0 0.1 0.2 0.3 0.0 -0.3
Medication for pain relief, constipation, heartburn 0.5 0.8 1.2 1.1 1.1 1.0 0.1
Neck or shoulder pain in last month 0.1 0.2 0.4 0.1 0.3 0.4 0.7
Medication: Blood pressure 1.0 1.8 2.4 -1.4 -1.5 -1.4 0.9
Angina (self-reported) 2.0 2.6 3.6 -1.5 -1.8 -1.9 1.2
Migraine (self-reported) 0.5 0.6 1.8 -0.5 -0.3 -0.5 1.3
Medication: Ibuprofen 0.2 0.2 0.8 -0.1 -0.2 -0.0 -0.9
Medication: Allopurinol 0.6 0.9 1.4 1.2 1.0 1.0 0.2
Medication: Omeprazole 0.8 0.9 1.4 -1.2 -0.9 -1.1 0.3
Medication: Seretide 50 evohaler 0.1 0.2 0.3 0.1 0.5 -0.4 0.5
Mean time to correctly identify matches 0.7 1.4 2.1 -1.0 -1.1 -1.0 -1.5
Heart disease (mother) 0.1 0.2 0.5 0.0 0.3 -0.1 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.7 2.6 1.6 1.6 1.1 -0.8
Whole body fat mass 1.8 7.3 16.3 2.4 1.6 2.2 -4.0
Leg fat mass (right) 1.2 4.6 12.0 1.7 1.1 1.6 -3.5
Arm predicted mass (right) 4.2 21.7 64.2 3.0 1.5 3.4 -8.0
Pulse rate, automated reading 1.1 3.5 4.9 -2.2 -2.0 -2.0 1.0
Alcohol intake frequency. 0.1 0.3 0.5 -0.3 -0.4 -0.6 0.7
Comparative height size at age 10 8.8 48.4 108.2 5.7 4.0 6.0 -10.4
Number of full sisters 2.2 2.7 4.1 2.0 1.7 2.0 -0.1
Suffer from ‘nerves’ 1.4 2.1 2.5 -1.4 -1.6 -1.4 1.4
Overall health rating 1.3 2.7 4.1 -1.9 -1.9 -2.0 0.1
Chest pain or discomfort 0.0 0.1 0.1 -0.3 -0.1 -0.3 0.1
Had major operations 0.1 0.1 0.3 0.1 -0.2 0.5 0.0
Age at last live birth 0.5 0.7 1.3 -1.1 -0.8 -1.0 0.0
Family relationship satisfaction 0.2 0.2 0.5 -0.5 -0.7 -0.1 -0.4
Leg pain on walking 0.5 0.7 1.0 -0.9 -1.0 -0.7 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.6 0.8 0.5 0.5 -0.0
Commuting to job workplace: Car/motor vehicle 1.1 1.3 4.4 0.0 0.6 -0.5 2.1
Illness, injury, bereavement, stress in last 2 years 4.3 5.2 7.1 -2.7 -2.5 -2.5 1.0
Medication: Aspirin 0.5 0.7 0.9 -0.6 -0.8 -0.8 1.0
Supplements: Vitamin C 1.0 1.2 1.8 1.0 1.1 1.4 -0.9
Knee pain experienced in last month 1.3 1.9 2.9 1.7 1.6 1.5 0.1
Hypertension (Self-reported) 1.7 4.7 6.6 -2.6 -2.5 -2.3 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.4 4.1 -1.6 -1.8 -2.0 -0.1
Illnesses of father: Heart disease 0.0 0.1 0.1 -0.3 0.1 0.1 -0.3
Illnesses of siblings: Diabetes 1.3 1.6 2.1 1.3 1.4 0.9 -1.3
Smoking status: Previous 1.1 1.7 3.8 0.8 -0.0 1.5 -1.9
Forced expiratory volume in 1-second (FEV1), predicted 4.6 9.5 25.3 2.2 1.5 2.4 -5.0
Whole body fat-free mass 4.2 24.1 69.4 3.3 1.6 3.7 -8.3
Leg fat-free mass (right) 2.7 14.5 39.7 2.8 1.3 3.0 -6.3
Arm fat percentage (left) 0.1 0.3 0.6 0.8 0.6 0.3 -0.2
Average weekly red wine intake 0.3 0.4 0.6 -0.7 -0.7 -0.2 0.6
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.3 0.3 0.2 0.5 -0.4
Mood swings 0.4 0.7 1.2 -0.7 -1.1 -0.9 -0.4
Loneliness, isolation 0.1 0.2 0.3 -0.1 -0.5 -0.4 0.5
Long-standing illness, disability or infirmity 0.4 0.6 0.9 -0.6 -0.9 -0.8 0.8
Ever had bowel cancer screening 0.5 0.5 1.4 -0.4 -0.2 -0.7 1.2
Diabetes diagnosed by doctor 0.1 0.2 0.8 0.3 0.1 -0.0 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.3 -0.5 -0.5 -0.3 -0.1
Friendships satisfaction 0.1 0.2 0.4 -0.1 0.1 0.4 0.7
Qualifications: nursing, teaching 0.2 0.3 0.5 -0.6 -0.7 -0.7 0.3
Commuting to job workplace: Walk 0.6 0.6 1.2 0.9 0.3 1.1 -0.6
Eye problems/disorders: Cataract 1.3 1.5 1.9 -1.2 -1.4 -1.1 1.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.2 -0.4 0.2 -0.5 0.4
Medication for cholesterol 0.0 0.1 0.1 0.3 0.3 0.1 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.6 -0.8 -0.5 -0.5 -0.7
Back pain experienced in last month 3.1 4.5 5.5 -2.3 -1.9 -2.3 2.0
Mineral and other dietary supplements 0.0 0.1 0.1 -0.1 -0.1 -0.3 0.3
Breast cancer (self-reported) 0.4 0.5 1.1 -0.5 -0.4 -0.7 -1.1
Asthma (self-reported) 0.3 0.7 1.2 0.7 1.1 0.4 -1.0
Osteoporosis (self-reported) 0.6 0.7 1.7 0.7 1.3 0.8 0.1
Osteoarthritis (self-reported) 0.0 0.1 0.1 0.1 0.1 0.3 -0.3
Medication: Aspirin 0.1 0.2 0.3 -0.3 -0.4 -0.4 0.5
Medication: Gliclazide 1.4 1.5 2.7 1.6 1.3 1.1 -0.6
Illnesses of father: None of the above (group 1) 0.2 0.3 0.5 -0.5 -0.5 -0.4 -0.7
Smoking status: Current 0.1 0.1 0.2 0.0 -0.3 -0.5 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.6 4.3 1.4 2.1 1.4 -1.6
Whole body water mass 4.3 24.4 70.7 3.3 1.6 3.7 -8.4
Leg predicted mass (right) 2.6 14.1 38.7 2.7 1.2 2.9 -6.2
Arm fat mass (left) 0.9 3.9 9.1 1.7 1.0 1.6 -3.0
Number of self-reported non-cancer illnesses 0.1 0.2 0.3 -0.4 -0.5 -0.4 0.5
Average weekly champagne plus white wine intake 0.5 0.7 1.2 -0.7 -0.9 -0.7 -1.1
Miserableness 0.2 0.4 0.6 -0.2 -0.8 -0.6 0.6
Guilty feelings 0.4 0.6 0.9 -0.9 -0.8 -0.4 0.9
Wears glasses or contact lenses 0.1 0.1 0.4 0.3 0.6 0.0 0.0
Ever taken oral contraceptive pill 3.0 3.4 5.4 -1.6 -1.8 -1.6 2.3
Hearing aid user 0.3 0.3 0.6 0.6 0.3 0.8 -0.4
Mother’s age at death 0.8 1.0 3.8 -0.3 -0.1 -0.5 1.9
Financial situation satisfaction 1.5 1.8 2.1 -1.4 -1.3 -1.4 1.3
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.4 -0.6 -0.6 -0.1 -0.6
Commuting to job workplace: Public transport 1.0 1.2 4.7 0.3 0.1 0.3 -2.2
Eye problems/disorders: Glaucoma 0.5 0.6 1.1 -0.7 -0.8 -0.4 1.1
Medication: Blood pressure 0.0 0.1 0.1 -0.2 -0.4 0.1 0.2
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 0.2 0.5 0.1 0.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 0.7 0.7 1.0 -0.4
High cholesterol (Self-reported) 0.3 0.6 0.7 -0.8 -0.8 -0.6 -0.8
Medication: Bendroflumethiazide 1.3 2.0 3.1 -1.5 -1.8 -1.6 -0.3
Medication: Paracetamol 0.1 0.2 0.3 -0.5 -0.5 -0.3 0.4
Medication: Lisinopril 0.8 1.0 1.6 -1.3 -1.0 -1.0 0.5
Medication: Atorvastatin 1.2 1.5 4.8 0.4 0.9 0.3 2.2
Illnesses of father: High blood pressure 0.6 0.8 1.1 1.0 1.1 0.8 -0.5
Alcohol drinker status: Never 1.8 2.2 3.1 -1.7 -1.8 -1.6 -0.3
Ever smoked 1.2 2.1 3.5 1.1 0.5 1.9 -1.9
Basal metabolic rate 4.1 22.8 64.0 3.3 1.7 3.6 -8.0
Leg fat percentage (left) 0.2 0.9 1.1 1.0 1.0 0.7 -1.0
Arm fat-free mass (left) 4.4 22.1 63.0 3.1 1.6 3.6 -7.9
Number of operations (self-reported) 0.2 0.3 0.5 -0.6 -0.7 -0.3 0.2
Average weekly beer plus cider intake 0.0 0.0 0.1 0.2 0.1 0.1 0.2
Irritability 0.7 1.1 2.0 -0.9 -1.4 -1.0 -0.8
Risk taking 0.1 0.1 0.3 -0.4 -0.5 0.1 -0.1
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.1 -1.0 -0.8 -1.1 -0.1
Fractured/broken bones in last 5 years 0.2 0.3 0.9 -0.0 -0.4 0.1 -0.9
Age started oral contraceptive pill 0.2 0.3 0.4 -0.6 -0.6 -0.7 -0.2
Diastolic blood pressure, automated reading 0.1 0.3 0.7 -0.8 -0.7 -0.4 0.2
Ever depressed for a whole week 0.3 0.3 1.2 0.0 -0.1 0.0 -1.1
Unable to work because of sickness or disability 0.1 0.2 0.7 -0.2 -0.8 0.0 0.1
Commuting to job workplace: Cycle 0.0 0.0 0.1 -0.1 -0.3 0.0 -0.1
Myopia 1.1 1.6 2.5 1.6 1.4 1.4 -0.5
Vascular/heart problems diagnosed by doctor 1.8 5.0 6.5 2.5 2.6 2.4 -1.3
Cholesterol lowering medication 0.2 0.3 1.1 -0.3 -0.2 -0.1 1.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.3 -1.0 -0.7 -1.2 0.6
Pain experienced in last month 2.2 3.7 6.1 2.0 1.4 1.7 -2.5
Supplements: Calcium 0.3 0.3 0.7 0.3 0.3 0.8 0.6
Basal cell carcinoma (self-reported) 0.4 0.4 0.8 0.6 0.9 0.5 -0.5
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.9 -0.6 -0.9 -0.6 0.7
Deep venous thrombosis (DVT) (self-reported) 2.7 3.5 4.0 2.0 2.0 2.0 -1.5
Heart disease (siblings) 0.2 0.3 0.8 -0.2 -0.5 -0.1 -0.9
Alcohol drinker status: Previous 0.2 0.2 0.8 0.2 0.1 0.1 0.9
Pack years of smoking 0.0 0.0 0.1 0.1 -0.4 -0.0 -0.0
Impedance of whole body 0.2 1.0 2.9 0.1 0.9 -0.2 1.7
Leg fat mass (left) 1.3 5.0 12.7 1.8 1.1 1.6 -3.6
Arm predicted mass (left) 4.5 23.0 66.4 3.2 1.7 3.5 -8.2