TWAS hub - EDC3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Esophageal Carcinoma	0.329	0.155	0.0030	0.008	0.010	0.024	NA	0.014	0.18000	0.160	0.05900	NA	0.1200
2	TCGA	Liver Hepatocellular Carcinoma	0.166	0.078	0.0073	0.079	0.013	0.068	NA	0.047	0.00014	0.075	0.00039	NA	0.0028

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Mother’s age at death	6.1	7.6	11.0	2.1	3.3
Medication: Ramipril	5.7	7.3	11.2	-1.8	3.3
Supplements: Vitamin C	5.7	6.7	13.3	0.3	3.7
Sitting height	4.2	30.1	49.3	-3.3	7.0
Father’s age at death	4.0	5.3	6.9	2.6	1.9
Commuting to job workplace: Cycle	3.8	4.6	8.5	2.9	0.8
Bipolar Disorder (2011)	3.6	3.5	6.5	-2.5	0.7
Diastolic blood pressure, automated reading	3.6	11.3	12.1	-3.5	3.2
Medication: Gliclazide	3.5	4.0	5.3	-1.7	2.3
Eye problems/disorders: Diabetes related eye disease	3.4	3.7	7.3	-0.3	2.7
Standing height	3.1	31.1	61.3	-0.9	7.8
Gout (self-reported)	3.0	4.1	4.4	-2.1	1.9
Medication: Blood pressure	2.9	5.2	5.3	-2.2	2.3
Relative age voice broke	2.7	4.1	7.8	2.8	0.7
Age at First Birth	2.6	3.7	5.4	1.4	2.3
Leg pain on walking	2.6	3.2	6.3	-2.5	0.5
Height	2.5	48.3	95.5	-1.0	9.8
Average weekly fortified wine intake	2.5	2.9	5.3	-0.7	2.3
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	4.5	2.1	0.9
Comparative height size at age 10	2.5	13.7	26.0	-1.2	5.1
Ever had bowel cancer screening	2.4	2.8	4.9	0.9	2.2
Pulse rate, automated reading	2.2	7.1	13.7	-3.7	-0.7
Hypertension (Self-reported)	2.2	6.1	11.8	-0.7	3.4
Average weekly red wine intake	2.2	3.2	4.0	1.6	-2.0
Type 2 Diabetes (T2D) (2012)	2.1	2.4	4.6	-2.1	0.5
Serious illness, injury or assault to yourself	2.1	2.6	4.0	1.1	-2.0
Diabetes diagnosed by doctor	2.1	3.4	3.6	-1.9	1.8
Diabetes (self-reported)	2.0	3.1	4.2	-2.0	1.5
Comparative body size at age 10	2.0	5.4	5.7	2.4	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	4.5	-0.6	2.1
Risk taking	2.0	2.9	5.7	0.4	2.4
Systolic Blood Pressure	1.9	9.4	12.2	-3.5	2.6
Forced vital capacity (FVC)	1.9	7.4	11.7	-1.7	3.4
Number of full brothers	1.9	2.4	4.4	-0.6	-2.1
Myopia	1.9	2.8	4.3	-1.1	2.1
Vascular/heart problems diagnosed by doctor	1.9	5.1	9.5	0.9	-3.1
Cardiovascular Disease	1.8	6.0	7.9	-2.0	2.8
Qualifications: nursing, teaching	1.8	2.8	5.0	0.7	2.2
Illnesses of father: High blood pressure	1.8	2.2	4.0	-2.0	0.7
High blood pressure	1.7	4.8	8.9	-0.8	3.0
Hair/balding pattern: Pattern 3	1.7	2.5	3.8	-1.1	1.9
Osteoarthritis (self-reported)	1.7	2.2	4.2	-0.3	-2.1
Vitamin and mineral supplements	1.6	2.1	4.1	-0.4	-2.0
Happiness	1.6	2.0	2.7	-1.1	-1.6
Eye problems/disorders: None of the above	1.6	1.8	3.6	0.3	-1.9
Commuting to job workplace: Walk	1.6	1.7	3.4	1.8	0.3
Wears glasses or contact lenses	1.6	1.8	3.7	0.1	1.9
Type 2 Diabetes (T2D) (2018)	1.5	2.8	3.1	-1.6	1.8
Qualifications: CSEs or equivalent	1.5	2.0	2.4	-1.3	-1.5
Asthma	1.5	2.9	4.6	-1.1	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	2.9	1.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	5.9	-0.7	2.4
Hand grip strength (left)	1.4	3.8	4.6	-2.2	1.7
Had other major operations	1.4	1.7	3.3	-0.4	-1.8
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	2.5	1.5	-1.6
Forced vital capacity (FVC), Best measure	1.4	5.0	6.3	-1.9	2.5
Medication: Allopurinol	1.4	1.8	2.4	-1.6	1.1
Medication: Omeprazole	1.4	1.6	3.1	0.3	1.8
Illnesses of father: Heart disease	1.4	1.9	3.8	-2.0	-0.1
Unable to work because of sickness or disability	1.4	1.8	3.5	-1.9	0.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.3	0.2	1.8
Lupus	1.3	1.9	3.3	-1.8	0.7
Allergy or Eczema	1.3	3.4	6.8	2.6	0.3
Diabetes (mother)	1.3	1.7	3.3	0.0	1.8
Fed-up feelings	1.3	2.4	2.6	-1.5	-1.6
Mouth/teeth dental problems	1.3	2.0	2.8	-1.7	1.1
Trunk fat-free mass	1.3	7.5	14.9	-0.3	3.9
Trunk predicted mass	1.3	7.5	15.0	-0.3	3.9
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.8	-0.7	-2.0
Asthma (self-reported)	1.3	2.7	4.2	-1.1	2.0
Smoking status: Current	1.3	2.0	3.1	-1.8	-1.0
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.4	0.3	1.8
Mean Putamen Volume	1.2	1.4	2.7	0.4	-1.6
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	5.9	-1.4	2.4
Medication: Aspirin	1.2	1.5	2.1	-1.0	1.4
Guilty feelings	1.2	1.8	3.3	-1.8	-0.6
Medication: Paracetamol	1.2	1.9	2.6	-1.6	-1.1
Medication: Metformin	1.1	1.6	3.1	-1.7	0.3
Mouth/teeth dental problems: Dentures	1.1	1.9	2.9	0.9	-1.7
Medication: Amlodipine	1.1	1.6	2.2	-0.9	1.5
Arm fat-free mass (right)	1.1	5.5	10.9	-0.3	3.3
Family relationship satisfaction	1.1	1.4	2.1	-0.9	-1.4
Ever depressed for a whole week	1.1	1.3	2.0	-0.8	-1.4
Hand grip strength (right)	1.0	2.9	4.7	-1.0	2.2
Current tobacco smoking	1.0	1.6	2.9	-1.7	-0.6
High blood pressure (mother)	1.0	1.4	1.8	-1.0	1.3
Pulse rate	1.0	1.7	2.6	-1.6	0.9
Hair/balding pattern: Pattern 4	1.0	2.4	4.4	-2.1	-0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.4	0.2	-1.5
Arm predicted mass (right)	1.0	5.3	10.6	-0.0	3.3
Whole body fat-free mass	1.0	5.9	11.8	-0.0	3.4
Whole body water mass	1.0	5.7	11.3	-0.1	3.4
Hearing aid user	1.0	1.2	1.6	-1.3	0.8
Medication: Blood pressure	1.0	1.9	3.7	0.3	1.9
Arm fat-free mass (left)	1.0	4.9	9.9	-0.1	3.1
Alzheimer’s Disease (in mother)	0.9	1.1	1.6	1.3	-0.7
Major Depression (MDD)	0.9	1.0	2.0	-1.4	-0.2
Ovarian Cancer	0.9	1.1	1.7	0.8	1.3
HbA1C	0.9	1.0	1.8	0.5	-1.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.2	0.2	-1.5
Supplements: Zinc	0.9	1.0	1.3	1.2	0.8
Severe depression (siblings)	0.9	1.0	1.9	-1.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	1.4	-0.9	-1.2
Medication: Levothyroxine sodium	0.9	1.5	2.2	0.9	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	3.9	-1.4	2.0
Peak expiratory flow (PEF)	0.9	2.1	3.4	0.9	1.8
Medication: Paracetamol	0.9	1.6	2.6	-1.6	-0.7
Pulse wave peak to peak time	0.9	1.1	2.0	1.4	-0.3
Smoking status: Previous	0.9	1.4	2.3	1.5	0.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	1.9	1.4	-1.0
Basal metabolic rate	0.9	5.0	9.9	-0.0	3.1
Age started oral contraceptive pill	0.9	1.1	1.6	1.3	0.7
Bipolar Disorder (2018)	0.8	1.3	1.9	-1.4	0.8
Blood Eosinophil Count	0.8	6.0	7.5	2.1	2.7
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.1	1.8	0.5
Hearing difficulty/problems with background noise	0.8	1.3	2.2	1.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	1.4	-1.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.6	0.6	-1.3
Pulse wave Arterial Stiffness index	0.8	0.9	1.4	-1.2	0.7
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.8	0.4	-1.7
Angina (self-reported)	0.8	1.0	1.9	1.4	-0.4
Number of full sisters	0.8	0.9	1.8	0.3	-1.3
Leg fat-free mass (right)	0.8	4.0	8.1	-0.0	2.8
Friendships satisfaction	0.8	1.0	1.8	-0.3	-1.3
Mineral and other dietary supplements	0.8	1.1	1.3	-1.1	-1.0
Breast cancer (self-reported)	0.8	0.9	1.8	1.4	0.1
Leg predicted mass (right)	0.8	4.0	8.0	-0.2	2.8
Ever taken oral contraceptive pill	0.8	0.9	1.1	-1.1	-0.8
Commuting to job workplace: Public transport	0.8	0.9	1.4	1.2	0.7
Medication: Lisinopril	0.8	1.0	1.5	-0.7	-1.2
Arm predicted mass (left)	0.8	4.1	8.1	0.3	2.8
Rheumatoid Arthritis	0.7	1.0	2.0	-1.4	0.1
Respiratory disease	0.7	1.6	2.8	-0.7	1.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.7	-0.3	1.3
Systolic blood pressure, automated reading	0.7	2.0	3.1	-1.8	0.9
Diabetes (father)	0.7	0.9	1.6	-1.3	-0.5
Pack years adult smoking proportion	0.7	1.1	2.1	-0.4	-1.4
Leg fat-free mass (left)	0.7	3.9	7.7	-0.1	2.8
Leg predicted mass (left)	0.7	3.8	7.5	-0.0	2.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	0.9	-0.8	-1.0
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.5	0.9	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.2	1.1	0.7
Illnesses of mother	0.7	0.8	1.6	-1.3	-0.2
Breastfed as a baby	0.7	0.9	1.8	-0.0	1.4
Ever highly irritable/argumentative for 2 days	0.7	0.8	0.9	-0.9	-0.9
Shortness of breath walking on level ground	0.7	0.8	1.6	-0.2	1.3
Emphysema/chronic bronchitis	0.7	0.7	0.7	0.9	0.9
Neck or shoulder pain in last month	0.7	0.9	1.2	1.1	-0.8
Medication: Ibuprofen	0.7	0.8	1.0	-0.8	-1.0
Suffer from ‘nerves’	0.7	1.1	2.1	0.4	-1.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.5	-1.2	-0.4
Long-standing illness, disability or infirmity	0.7	1.0	1.9	-0.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.1	-1.8	-0.0
Medication: Bendroflumethiazide	0.7	1.1	2.2	0.1	1.5
Number of operations (self-reported)	0.7	1.1	2.0	-0.5	-1.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	1.2	-0.6
Pack years of smoking	0.7	1.1	2.1	-0.3	-1.4
Alzheimer’s Disease (including proxy)	0.6	0.9	0.9	0.9	-0.9
Neuroticism (2016)	0.6	0.8	0.9	-0.9	-1.0
Blood Platelet Count	0.6	6.8	9.6	-2.0	-3.1
Relative age of first facial hair	0.6	1.3	1.7	1.3	0.9
Townsend deprivation index at recruitment	0.6	0.8	0.9	-0.9	-0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	0.8	-0.9	-0.8
Qualifications: None of the above	0.6	1.3	2.6	0.3	-1.6
Pain all over the body in last month	0.6	0.6	0.8	-0.9	-0.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	1.3	-0.2
Weight	0.6	2.9	5.8	0.0	2.4
Hip circumference	0.6	2.8	5.5	-0.2	2.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	0.8	-0.9	0.9
Exposure to tobacco smoke outside home	0.6	0.8	1.1	-1.1	-0.7
Had major operations	0.6	0.7	1.4	-1.2	0.3
Medication: Aspirin	0.6	0.8	1.5	-0.4	1.2
Average weekly beer plus cider intake	0.6	0.8	1.4	-0.5	1.2
Fractured/broken bones in last 5 years	0.6	0.8	1.5	1.2	-0.0
Triglycerides	0.5	0.8	0.9	1.0	0.9
Angina	0.5	0.6	1.2	1.1	-0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	-1.0	-0.5
Past tobacco smoking	0.5	0.8	1.3	-1.1	-0.6
Financial difficulties in last 2 years	0.5	0.6	1.1	-0.4	-1.1
Allergy	0.5	1.2	2.0	-0.6	-1.4
Medication: Simvastatin	0.5	0.8	1.3	-1.1	0.6
Worrier / anxious feelings	0.5	0.9	1.2	-0.8	-1.1
Noisy workplace	0.5	0.6	1.1	-1.1	0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.8	0.8	0.9
Glaucoma (self-reported)	0.5	0.6	1.1	0.3	-1.0
Number of children fathered	0.5	0.5	0.8	0.9	-0.5
Overall health rating	0.5	1.0	1.4	-0.8	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	1.3	-1.1	-0.0
Medication for cholesterol	0.5	0.8	1.2	0.6	-1.1
Back pain experienced in last month	0.5	0.8	1.6	1.2	-0.1
Illnesses of father: None of the above (group 1)	0.5	0.7	1.0	1.0	0.5
Prostate Cancer	0.4	0.6	1.0	0.5	1.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.0	1.0	-0.3
BMI	0.4	2.5	3.4	1.8	-1.3
Hypothyroidism (self reported)	0.4	0.8	1.4	1.2	-0.5
Sensitivity / hurt feelings	0.4	0.7	1.3	0.4	-1.1
Medication for hormone replacement therapy	0.4	0.4	0.9	0.1	0.9
Medication: Co-codamol	0.4	0.5	0.8	-0.5	-0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.0	-0.3	1.0
Multivitamins +/- minerals	0.4	0.5	0.7	-0.8	0.6
Supplements: Glucosamine	0.4	0.5	0.9	0.9	-0.5
Medication: Atenolol	0.4	0.5	0.7	-0.5	0.8
Alcohol usually taken with meals	0.4	0.6	0.7	0.7	-0.8
Illnesses of siblings	0.4	0.5	0.8	0.5	0.9
Neuroticism score	0.4	0.8	0.9	-1.0	-0.9
Time employed in main current job	0.4	0.5	0.7	-0.8	0.5
Medication: Cholesterol lowering	0.4	0.6	1.2	-1.1	0.2
Birth weight of first child	0.4	0.7	1.1	1.1	0.6
Birth weight	0.4	0.8	1.5	-0.3	1.2
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.7	0.4	-0.8
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.7	0.4	0.9
Mood swings	0.4	0.8	1.6	-1.2	-0.1
Alcohol drinker status: Never	0.4	0.4	0.4	0.7	-0.7
Ever smoked	0.4	0.7	0.7	0.8	0.9
Basal cell carcinoma (self-reported)	0.4	0.5	0.7	0.8	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.8	1.5	-1.2	-0.0
Fasting Glucose	0.3	0.3	0.6	0.2	0.8
HDL Cholesterol	0.3	0.4	0.7	-0.9	-0.4
Heel T-Score	0.3	2.5	3.4	1.2	-1.8
Number of treatments/medications taken	0.3	0.5	1.0	-1.0	-0.2
Hearing difficulty/problems: Yes	0.3	0.4	0.8	-0.3	0.9
Impedance of leg (right)	0.3	1.4	2.8	-1.7	-0.0
Taking other prescription medications	0.3	0.4	0.8	-0.2	-0.9
Stomach or abdominal pain in last month	0.3	0.4	0.7	-0.2	-0.9
Impedance of leg (left)	0.3	1.3	2.5	-1.6	0.1
Trunk fat mass	0.3	1.1	1.8	0.6	1.4
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	0.5	-0.7
Had menopause	0.3	0.4	0.7	0.8	0.4
Arm fat percentage (right)	0.3	1.1	1.2	1.1	-1.0
Falls in the last year	0.3	0.4	0.7	-0.8	0.1
Depression (self-reported)	0.3	0.4	0.7	0.4	-0.8
Medication: Lansoprazole	0.3	0.3	0.4	0.6	-0.5
Leg fat percentage (right)	0.3	1.2	2.3	0.3	-1.5
Worry too long after embarrassment	0.3	0.6	0.8	-0.6	-0.9
Health satisfaction	0.3	0.3	0.7	-0.1	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	0.9	0.9	0.4
Migraine (self-reported)	0.3	0.3	0.7	-0.0	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.7	0.3
Eye problems/disorders: Cataract	0.3	0.4	0.7	-0.1	0.9
Miserableness	0.3	0.6	1.2	-1.1	-0.1
Financial situation satisfaction	0.3	0.4	0.7	-0.4	-0.8
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.9	0.0
Leg fat percentage (left)	0.3	1.0	1.8	0.5	-1.4
Supplements: Calcium	0.3	0.4	0.6	0.8	0.4
Alcohol drinker status: Previous	0.3	0.3	0.5	-0.2	-0.7
Depressed Affect (Nagel 2018)	0.2	0.5	0.5	-0.7	-0.6
Depression (Nagel 2018)	0.2	0.2	0.5	0.1	-0.7
Neuroticism (Nagel 2018)	0.2	0.5	0.9	-0.1	-1.0
Schizophrenia (2018)	0.2	0.3	0.4	0.5	-0.7
Worry (Nagel 2018)	0.2	0.3	0.6	0.3	-0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.2	-0.5
Crohns Disease (2017)	0.2	0.4	0.9	-0.9	-0.2
Ulcerative Colitis (UC)	0.2	0.4	0.5	-0.7	0.5
Reaction Time	0.2	0.4	0.6	-0.8	-0.6
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.4	-0.7
Blood Red Count	0.2	2.1	3.5	-0.8	1.9
Blood White Count	0.2	1.2	2.2	-1.5	-0.6
Lung FEV1/FVC ratio	0.2	1.1	2.0	1.4	-0.3
Maternal smoking around birth	0.2	0.3	0.6	-0.8	0.2
Body mass index (BMI)	0.2	0.9	1.4	0.5	-1.2
Number of live births	0.2	0.3	0.3	0.5	-0.5
Prospective memory result	0.2	0.3	0.3	-0.6	0.4
Length of working week for main job	0.2	0.2	0.3	0.5	0.5
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.6	-0.1
Loud music exposure frequency	0.2	0.2	0.2	0.5	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.7	0.1
Age at first live birth	0.2	0.3	0.5	0.7	0.3
Qualifications: College or University degree	0.2	0.5	0.6	0.6	0.8
Mean time to correctly identify matches	0.2	0.3	0.4	-0.5	-0.6
Heart disease (mother)	0.2	0.3	0.3	-0.6	-0.5
Arm fat percentage (left)	0.2	0.9	1.1	0.8	-1.0
Loneliness, isolation	0.2	0.2	0.5	-0.7	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.1	-0.7
High cholesterol (Self-reported)	0.2	0.3	0.4	-0.5	-0.6
Pain experienced in last month	0.2	0.3	0.4	-0.6	0.6
Heart disease (siblings)	0.2	0.2	0.3	-0.3	-0.6
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.0	-0.5
Irritable Bowel Disease (IBD)	0.1	0.1	0.2	-0.4	0.3
LDL Cholesterol	0.1	0.1	0.1	0.4	-0.4
Schizophrenia (2014)	0.1	0.3	0.5	-0.7	-0.2
Waist Hip Ratio (WHR)	0.1	0.6	1.0	1.0	-0.3
Lung FVC	0.1	0.6	1.1	-1.1	-0.2
Neuroticism	0.1	0.3	0.6	0.1	-0.7
Chronotype (morning person)	0.1	0.1	0.2	0.4	-0.3
Average weekly spirits intake	0.1	0.1	0.2	0.4	-0.1
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.3	0.4
Trunk fat percentage	0.1	0.3	0.5	0.7	0.3
Age when periods started (menarche)	0.1	0.2	0.2	-0.4	-0.4
Waist circumference	0.1	0.2	0.4	0.2	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.2	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	0.1	0.7
Heart attack	0.1	0.1	0.2	-0.4	0.3
Impedance of arm (right)	0.1	0.4	0.8	-0.1	0.9
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.5	-0.2
Impedance of arm (left)	0.1	0.2	0.5	-0.1	0.7
Arm fat mass (right)	0.1	0.4	0.5	0.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.5	-0.2
Pulse wave reflection index	0.1	0.1	0.2	-0.5	-0.1
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.1	0.4
Headache pain in last month	0.1	0.1	0.2	-0.2	0.5
Body fat percentage	0.1	0.3	0.4	0.6	-0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.6	-0.3
Whole body fat mass	0.1	0.4	0.6	0.4	0.8
Alcohol intake frequency.	0.1	0.2	0.5	0.7	-0.1
Chest pain or discomfort	0.1	0.1	0.2	-0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.2	-0.4	0.5
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.3	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.1	0.3	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.3	0.5	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.2	0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	0.4	-0.0
Medication: Atorvastatin	0.1	0.1	0.3	0.5	0.1
Irritability	0.1	0.2	0.2	-0.3	0.5
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	-0.1	-0.2
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.1	0.2	-0.4
Breast Cancer	0.0	0.1	0.2	-0.4	0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.1	-0.2
Crohns Disease (2012)	0.0	0.0	0.0	-0.0	-0.1
Ulcerative Colitis	0.0	0.0	0.1	0.2	-0.1
Smoking Status	0.0	0.0	0.1	-0.1	0.3
Hair Pigment	0.0	0.3	0.3	0.6	0.6
Tanning	0.0	0.5	0.5	-0.7	0.7
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	0.1	0.4
Number of incorrect matches in round	0.0	0.0	0.1	-0.1	0.3
Nervous feelings	0.0	0.1	0.2	0.1	-0.4
Fluid intelligence score	0.0	0.1	0.2	-0.1	-0.4
Lung cancer (father)	0.0	0.0	0.0	0.0	0.2
Tense / ‘highly strung’	0.0	0.0	0.0	-0.1	-0.2
High blood pressure (siblings)	0.0	0.1	0.1	-0.1	-0.4
Medication: Seretide 50 evohaler	0.0	0.0	0.0	0.2	-0.1
Leg fat mass (right)	0.0	0.0	0.0	0.1	0.1
Age at last live birth	0.0	0.1	0.1	-0.3	0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.2	0.1
Knee pain experienced in last month	0.0	0.1	0.1	0.2	0.3
Arm fat mass (left)	0.0	0.2	0.3	0.6	0.1
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.3	-0.1
Cholesterol lowering medication	0.0	0.0	0.0	-0.1	-0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.3	0.0
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.1	-0.0	0.3
Impedance of whole body	0.0	0.2	0.3	-0.4	0.6
Leg fat mass (left)	0.0	0.1	0.1	0.3	0.2

Hub : Genes

EDC3

Models

Trait associations