TWAS hub - EDNRB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0465	0.0171	3.1e-05	0.032	0.036	0.035	0.036	0.031	1.1e-05	3.7e-06	5.4e-06	3.1e-06	1.4e-05
2	TCGA	Breast Invasive Carcinoma	0.0174	0.0112	6.3e-03	0.002	0.005	0.001	NA	0.001	1.3e-01	3.1e-02	1.6e-01	NA	1.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hair Pigment	25.6	730.9	747.0	26.7	27.3
Impedance of leg (right)	15.4	74.8	91.4	-7.6	-9.6
Impedance of leg (left)	14.3	69.5	85.3	-7.3	-9.2
Leg fat-free mass (right)	13.3	70.9	79.6	7.9	8.9
Leg predicted mass (right)	13.3	71.0	79.5	7.9	8.9
Leg fat-free mass (left)	12.4	65.4	72.5	7.6	8.5
Leg predicted mass (left)	12.1	64.0	71.0	7.5	8.4
Whole body water mass	10.8	61.6	72.4	7.1	8.5
Whole body fat-free mass	10.3	59.0	69.2	7.0	8.3
Basal metabolic rate	9.3	51.5	59.6	6.6	7.7
Trunk fat-free mass	8.8	50.3	61.3	6.3	7.8
Trunk predicted mass	8.7	49.9	60.8	6.2	7.8
Arm fat-free mass (right)	7.9	40.4	46.0	5.9	6.8
Birth weight	7.5	16.2	25.1	2.7	5.0
Arm predicted mass (right)	7.5	38.5	44.2	5.7	6.7
Forced vital capacity (FVC)	7.4	28.6	28.7	5.3	5.4
Ever had prostate specific antigen (PSA) test	7.3	8.4	14.3	1.6	3.8
Impedance of whole body	7.3	37.3	49.6	-5.0	-7.0
Multivitamins +/- minerals	6.8	8.6	13.8	-1.8	-3.7
Rheumatoid Arthritis	6.7	9.2	13.7	2.2	3.7
Wears glasses or contact lenses	6.5	7.5	10.6	2.1	3.3
Arm fat-free mass (left)	6.5	32.9	41.4	4.9	6.4
Arm predicted mass (left)	6.4	32.5	39.9	5.0	6.3
Vitamin and mineral supplements	6.2	8.4	10.0	2.6	3.2
Eye problems/disorders: Cataract	5.7	6.6	12.0	-1.1	-3.5
HbA1C	5.6	6.3	9.2	3.0	1.8
Weight	5.6	27.6	27.7	5.2	5.3
Forced vital capacity (FVC), Best measure	5.6	20.5	23.6	4.2	4.9
Forced expiratory volume in 1-second (FEV1)	5.1	17.0	17.2	4.1	4.1
Eye problems/disorders: None of the above	4.9	5.6	9.8	1.2	3.1
Supplements: Zinc	4.4	4.7	7.5	-1.4	-2.7
Fractured/broken bones in last 5 years	4.3	5.6	10.6	0.8	3.3
Primary Biliary Cirrhosis	4.1	5.8	9.2	1.6	3.0
Hair/balding pattern: Pattern 3	4.1	6.0	9.0	-1.8	-3.0
Forced expiratory volume in 1-second (FEV1), Best measure	3.9	12.4	14.5	3.2	3.8
Medication: Lansoprazole	3.6	4.1	5.3	-2.3	-1.7
Standing height	3.6	36.1	39.7	5.7	6.3
Breastfed as a baby	3.5	4.4	8.4	0.6	2.9
Heart attack/myocardial infarction (self-reported)	3.5	4.5	9.0	0.2	-3.0
Birth weight of first child	3.4	6.1	6.2	2.5	2.4
Supplements: Vitamin C	3.3	3.9	4.9	-1.7	-2.2
Supplements: Calcium	3.3	3.7	5.9	-1.2	-2.4
Prospective memory result	3.2	3.9	4.5	-1.8	-2.1
Illnesses of father: Heart disease	3.2	4.4	6.8	-1.5	-2.6
Hip circumference	3.1	13.2	14.7	3.8	3.4
Peak expiratory flow (PEF)	3.1	7.2	8.3	2.5	2.9
Fasting Glucose	3.0	3.5	5.2	2.3	1.4
Height	3.0	57.8	64.0	7.2	8.0
Heart attack	3.0	3.8	7.6	0.3	-2.8
Mineral and other dietary supplements	3.0	4.1	4.5	1.9	2.1
Sitting height	2.9	20.7	28.1	3.7	5.3
Impedance of arm (right)	2.8	13.1	17.9	-2.9	-4.2
Chronic bronchitis/emphysema (mother)	2.8	3.3	4.8	1.3	2.2
Depression (Nagel 2018)	2.7	4.1	7.4	2.7	0.9
BMI	2.7	15.4	19.8	3.3	4.5
Diabetes (mother)	2.7	3.5	3.8	2.0	1.8
Medication: Gliclazide	2.7	3.1	4.9	2.2	1.1
Hair/balding pattern: Pattern 2	2.6	3.3	4.9	2.2	1.3
Arm fat mass (left)	2.6	10.5	13.5	3.7	2.7
Hand grip strength (right)	2.5	6.8	8.7	2.2	2.9
Financial difficulties in last 2 years	2.4	3.2	3.3	1.8	1.8
Medication: Blood pressure	2.4	4.6	7.1	-1.4	-2.7
Supplements: Fish oil (including cod liver oil)	2.4	3.2	3.9	-1.6	-2.0
Ever used hormone-replacement therapy (HRT)	2.3	2.9	5.8	-0.3	-2.4
Impedance of arm (left)	2.3	10.4	17.1	-1.9	-4.1
Arm fat mass (right)	2.3	9.6	11.2	3.4	2.8
Headache pain in last month	2.3	4.0	6.0	-1.4	-2.5
Blood Platelet Count	2.2	26.1	45.3	-2.6	-6.7
Trunk fat mass	2.2	9.3	12.7	3.6	2.4
Diabetes (self-reported)	2.2	3.4	6.5	2.6	0.5
Medication: Simvastatin	2.2	3.2	4.0	-1.6	-2.0
Asthma	2.1	4.2	5.8	1.6	2.4
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	4.4	0.7	2.1
Blood White Count	2.0	15.0	24.8	-2.3	-5.0
High blood pressure (mother)	2.0	2.8	5.5	0.3	-2.3
Age at last live birth	2.0	2.9	4.6	1.1	2.1
Diabetes diagnosed by doctor	2.0	3.3	5.2	2.3	1.2
Alzheimer’s Disease (in mother)	1.9	2.2	3.2	-1.8	-1.1
LDL Cholesterol	1.9	2.9	3.2	-1.8	-1.7
Hand grip strength (left)	1.9	5.1	5.8	2.1	2.4
Allergy	1.9	4.4	7.0	-1.3	-2.6
Medication: Amlodipine	1.9	2.7	3.4	1.4	1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	2.1	1.5	1.4
Illnesses of mother	1.8	2.2	4.2	0.5	2.0
Wheeze or whistling in the chest in last year	1.8	3.3	6.1	2.5	0.7
Leg pain on walking	1.8	2.3	2.7	1.6	1.4
Illnesses of father: None of the above (group 1)	1.8	2.2	4.4	0.2	2.1
Major Depression (MDD)	1.7	2.0	3.6	1.9	0.7
Body Mass Index (BMI) (2010)	1.7	2.3	4.0	2.0	0.8
Medication: Co-codamol	1.7	2.0	2.3	-1.5	-1.3
Relative age voice broke	1.7	2.6	4.2	0.9	2.1
Waist circumference	1.7	6.3	10.0	3.2	1.6
Whole body fat mass	1.7	7.3	9.6	3.1	2.2
Asthma (self-reported)	1.7	3.5	4.9	1.5	2.2
Angina	1.6	2.1	4.2	2.0	0.1
Body mass index (BMI)	1.6	6.7	7.7	2.8	2.4
Angina (self-reported)	1.6	2.1	4.2	2.0	0.1
Medication: Ibuprofen	1.6	2.0	3.9	0.2	2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	4.0	1.7	2.0
Allergy or Eczema	1.5	4.0	7.5	0.7	2.7
Medication: Metformin	1.5	2.1	4.1	2.0	0.0
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.5	-0.5	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	2.9	-0.9	-1.7
Comparative height size at age 10	1.5	8.3	10.3	3.2	2.5
Ever taken oral contraceptive pill	1.5	1.6	3.0	-0.6	1.7
Cholesterol lowering medication	1.5	2.2	4.2	-0.4	-2.1
Type 2 Diabetes (T2D) (2018)	1.4	2.6	5.0	2.2	-0.5
Ever had hysterectomy (womb removed)	1.4	1.6	1.6	-1.3	-1.2
Knee pain experienced in last month	1.4	2.2	4.3	0.4	2.1
Osteoporosis (self-reported)	1.4	1.7	2.4	-1.5	-1.0
Waist Hip Ratio (WHR)	1.3	5.7	9.4	-1.4	-3.1
Frequency of depressed mood in last 2 weeks	1.3	1.9	3.0	1.7	0.9
Relative age of first facial hair	1.3	2.8	4.3	-1.1	2.1
Falls in the last year	1.3	1.7	3.2	0.4	1.8
Number of children fathered	1.3	1.5	2.9	1.7	0.3
Medication for cholesterol	1.3	1.9	3.0	1.0	1.7
Medication: Aspirin	1.3	1.7	3.1	-0.5	-1.8
High cholesterol (Self-reported)	1.3	2.2	3.3	-1.1	-1.8
Alcohol drinker status: Never	1.3	1.5	2.4	0.8	-1.6
Noisy workplace	1.2	1.5	2.5	0.7	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.9	0.2	1.7
Osteoarthritis (self-reported)	1.2	1.6	3.1	-0.0	1.8
Pain experienced in last month	1.2	2.0	3.4	1.9	0.8
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	1.5	1.1	1.2
Illnesses of siblings	1.1	1.6	3.2	-0.1	1.8
High blood pressure (siblings)	1.1	1.6	3.1	-0.4	-1.8
Number of full brothers	1.1	1.4	2.7	0.4	1.6
Medication: Bendroflumethiazide	1.1	1.6	1.9	-1.1	-1.4
Leg fat mass (left)	1.1	4.4	6.0	2.5	1.7
Crohns Disease (2012)	1.0	1.6	2.2	-1.0	-1.5
Blood Red Count	1.0	10.1	11.7	-2.9	-3.4
Happiness	1.0	1.2	1.5	1.2	0.9
Loud music exposure frequency	1.0	1.1	1.9	-1.4	-0.6
Health satisfaction	1.0	1.3	2.6	1.6	0.3
Medication: Seretide 50 evohaler	1.0	1.2	1.7	1.3	0.8
Chest pain or discomfort	1.0	1.5	2.4	1.6	-0.8
Had major operations	1.0	1.1	2.1	1.5	-0.4
Arm fat percentage (left)	1.0	4.1	7.0	2.6	1.1
Long-standing illness, disability or infirmity	1.0	1.6	2.4	1.5	0.9
Age started oral contraceptive pill	1.0	1.2	2.3	-1.5	-0.4
Unable to work because of sickness or disability	1.0	1.3	2.6	1.6	-0.0
Alzheimer’s Disease (in father)	0.9	1.0	1.1	0.9	1.1
Alzheimer’s Disease (including proxy)	0.9	1.3	2.0	-1.4	-0.8
Lung FVC	0.9	4.4	5.9	2.4	1.7
Chronotype (morning person)	0.9	2.1	2.7	1.6	-1.2
Average weekly spirits intake	0.9	1.1	2.1	1.5	0.0
Hayfever, allergic rhinitis or eczema	0.9	1.9	3.8	0.3	1.9
Medication: Ramipril	0.9	1.2	2.2	-0.3	-1.5
Leg fat mass (right)	0.9	3.7	5.3	2.3	1.4
Alcohol intake frequency.	0.9	2.0	3.6	0.7	-1.9
Risk taking	0.9	1.3	2.4	0.3	1.5
Vascular/heart problems diagnosed by doctor	0.9	2.5	4.9	0.4	2.2
Worry (Nagel 2018)	0.8	1.6	3.2	-0.1	-1.8
Neuroticism (2016)	0.8	1.1	1.5	-0.8	-1.2
Sensitivity / hurt feelings	0.8	1.4	1.5	1.2	1.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.1	-1.0	-0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.5	1.2	0.5
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.8	-0.3	-1.3
Suffer from ‘nerves’	0.8	1.2	1.7	0.9	-1.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.1	-1.0	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.2	-0.9	-1.1
Medication: Atorvastatin	0.8	1.0	2.1	0.1	-1.4
Cardiovascular Disease	0.7	2.3	4.4	-0.5	-2.1
Number of live births	0.7	1.0	2.0	-0.1	1.4
Pulse rate	0.7	1.2	2.1	1.4	0.5
Depression (self-reported)	0.7	0.8	1.1	1.0	0.7
Length of working week for main job	0.7	0.8	1.0	-0.7	1.0
Hair/balding pattern: Pattern 4	0.7	1.6	2.6	-0.8	-1.6
Leg fat percentage (right)	0.7	2.7	4.5	-0.9	-2.1
Family relationship satisfaction	0.7	0.8	1.5	1.2	0.3
Illnesses of siblings: Diabetes	0.7	0.9	1.6	-0.4	-1.3
Commuting to job workplace: Public transport	0.7	0.8	1.5	0.4	-1.2
Medication: Lisinopril	0.7	0.8	1.5	0.4	-1.2
HDL Cholesterol	0.6	1.0	1.1	-0.9	-1.1
Lupus	0.6	1.0	1.7	1.3	0.5
Lung FEV1/FVC ratio	0.6	2.9	3.8	-1.5	-1.9
Average weekly fortified wine intake	0.6	0.7	0.7	-0.8	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.5	1.2	-0.0
Age when periods started (menarche)	0.6	1.3	2.5	-0.4	1.6
High blood pressure	0.6	1.6	3.2	-0.2	-1.8
Supplements: Glucosamine	0.6	0.8	1.2	-1.1	-0.6
Arm fat percentage (right)	0.6	2.4	3.8	1.9	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.5	-0.0	1.2
Tense / ‘highly strung’	0.6	1.1	1.2	-1.0	-1.1
Shortness of breath walking on level ground	0.6	0.7	1.4	1.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.3	0.3	-1.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	0.8	-0.8	0.9
Hypertension (Self-reported)	0.6	1.6	3.0	-0.5	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.8	0.8	1.3
Average weekly champagne plus white wine intake	0.6	0.8	1.1	0.7	1.0
Financial situation satisfaction	0.6	0.8	1.4	1.2	0.5
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.2	-0.6	-1.1
Illnesses of father: High blood pressure	0.6	0.8	1.0	0.7	-1.0
Ever depressed for a whole week	0.6	0.8	0.9	0.8	1.0
Heart disease (siblings)	0.6	0.7	1.4	1.2	0.1
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.7	1.6	-0.4
Schizophrenia (2018)	0.5	0.9	1.4	0.7	-1.2
Ovarian Cancer	0.5	0.7	1.3	-1.1	-0.4
Triglycerides	0.5	0.8	1.3	0.5	-1.1
Trunk fat percentage	0.5	2.0	4.0	2.0	0.1
Taking other prescription medications	0.5	0.8	0.9	-0.9	-0.9
Serious illness, injury or assault to yourself	0.5	0.6	0.9	-0.9	0.5
Mouth/teeth dental problems	0.5	0.8	1.5	-0.1	1.2
Father’s age at death	0.5	0.7	0.7	0.8	0.8
Medication: Cholesterol lowering	0.5	0.8	1.0	-0.8	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.5	1.2	-0.2
Glaucoma (self-reported)	0.5	0.5	0.7	0.6	-0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	1.1	-0.1
Comparative body size at age 10	0.5	1.4	1.4	1.2	1.2
Medication: Aspirin	0.5	0.6	1.3	0.1	-1.1
Average weekly red wine intake	0.5	0.8	1.0	-1.0	-0.7
Mood swings	0.5	0.8	1.2	0.7	1.1
Friendships satisfaction	0.5	0.7	1.2	0.3	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.3	1.1	-0.5
Medication: Paracetamol	0.5	0.8	1.0	1.0	0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	1.0	1.0	-1.0
Crohns Disease (2017)	0.4	0.9	1.2	-0.8	-1.1
Reaction Time	0.4	0.7	1.0	-0.6	-1.0
Mean Putamen Volume	0.4	0.5	0.7	0.8	0.6
Schizophrenia (2014)	0.4	0.9	1.8	0.2	-1.4
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	0.9	0.2
Respiratory disease	0.4	1.0	1.0	1.0	1.0
Number of treatments/medications taken	0.4	0.6	0.9	-0.6	-1.0
Hearing difficulty/problems: Yes	0.4	0.7	0.8	0.9	0.7
Severe depression (siblings)	0.4	0.4	0.6	-0.5	0.8
Maternal smoking around birth	0.4	0.5	0.9	-0.3	1.0
Nervous feelings	0.4	0.8	1.3	-0.5	-1.1
Had menopause	0.4	0.5	0.7	-0.5	-0.9
Pain all over the body in last month	0.4	0.4	0.5	-0.7	-0.5
Alcohol intake versus 10 years previously	0.4	0.5	1.0	1.0	0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.8	0.1	1.3
Medication: Paracetamol	0.4	0.6	1.2	1.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	0.1	-1.0
Qualifications: College or University degree	0.4	1.4	1.6	-1.3	1.1
Mean time to correctly identify matches	0.4	0.8	1.3	-0.5	-1.2
Miserableness	0.4	0.7	1.1	1.0	0.6
Guilty feelings	0.4	0.6	1.2	-0.3	-1.1
Hearing aid user	0.4	0.4	0.7	0.4	-0.8
Leg fat percentage (left)	0.4	1.3	2.5	-0.4	-1.6
Number of operations (self-reported)	0.4	0.6	1.2	1.1	0.2
Average weekly beer plus cider intake	0.4	0.6	1.2	-1.1	-0.3
Diastolic blood pressure, automated reading	0.4	1.2	1.2	1.1	-1.0
Alcohol drinker status: Previous	0.4	0.4	0.5	0.7	-0.6
Pack years of smoking	0.4	0.6	1.2	1.1	0.0
Depressed Affect (Nagel 2018)	0.3	0.7	0.8	0.9	0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.5	0.7	-0.6
Coronary Artery Disease (CAD)	0.3	0.3	0.5	-0.4	-0.7
Hypothyroidism (self reported)	0.3	0.6	1.1	-0.5	-1.0
Current tobacco smoking	0.3	0.5	1.1	-0.1	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	1.2	-0.0
Qualifications: CSEs or equivalent	0.3	0.4	0.6	-0.3	-0.8
Stomach or abdominal pain in last month	0.3	0.4	0.6	-0.8	0.4
Medication: Atenolol	0.3	0.3	0.4	0.7	-0.4
Medication: Levothyroxine sodium	0.3	0.5	0.9	-0.3	-0.9
Time employed in main current job	0.3	0.3	0.4	0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.8	-0.9	-0.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	-0.1	-1.0
Worry too long after embarrassment	0.3	0.5	0.9	-0.1	0.9
Age at first live birth	0.3	0.5	1.0	1.0	0.2
Pulse wave peak to peak time	0.3	0.4	0.7	0.9	-0.1
Neck or shoulder pain in last month	0.3	0.5	0.9	-0.2	0.9
Pulse rate, automated reading	0.3	1.0	1.9	1.4	-0.2
Commuting to job workplace: Walk	0.3	0.3	0.3	-0.5	-0.5
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	0.1	0.8
Commuting to job workplace: Cycle	0.3	0.4	0.4	0.7	0.5
Bipolar Disorder (2018)	0.2	0.3	0.5	0.7	-0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.9	0.4	-1.0
Systolic Blood Pressure	0.2	1.2	2.3	0.3	-1.5
Smoking Status	0.2	0.6	1.1	-0.3	-1.0
Medication for hormone replacement therapy	0.2	0.2	0.3	0.5	-0.4
Diabetes (father)	0.2	0.3	0.5	0.2	-0.7
Pack years adult smoking proportion	0.2	0.3	0.4	0.6	-0.4
Townsend deprivation index at recruitment	0.2	0.3	0.4	-0.7	0.3
Fed-up feelings	0.2	0.3	0.4	0.6	-0.4
Number of incorrect matches in round	0.2	0.3	0.3	-0.5	-0.6
Alcohol usually taken with meals	0.2	0.3	0.5	-0.7	0.1
Had other major operations	0.2	0.2	0.3	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.9	0.4	-0.9
Qualifications: None of the above	0.2	0.5	0.9	-0.2	-0.9
Worrier / anxious feelings	0.2	0.3	0.5	0.3	-0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.5	0.4
Pulse wave reflection index	0.2	0.3	0.5	-0.7	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.6	0.4	0.7
Gout (self-reported)	0.2	0.3	0.6	-0.8	-0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.5	-0.6	-0.7
Body fat percentage	0.2	0.9	1.9	1.4	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.2	0.6
Medication: Blood pressure	0.2	0.3	0.5	0.2	0.7
Medication: Allopurinol	0.2	0.3	0.5	-0.3	0.7
Overall health rating	0.2	0.4	0.8	0.9	-0.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	-0.1	-0.6
Back pain experienced in last month	0.2	0.2	0.4	-0.6	-0.3
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	-0.4	-0.7
Ever smoked	0.2	0.3	0.7	-0.8	0.1
Neuroticism (Nagel 2018)	0.1	0.2	0.4	0.2	-0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.1	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.5	0.2
Prostate Cancer	0.1	0.1	0.2	0.5	-0.1
Age at First Birth	0.1	0.1	0.2	0.2	0.4
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.1	0.4
Ulcerative Colitis	0.1	0.1	0.2	0.4	0.3
Heel T-Score	0.1	0.8	1.6	0.2	-1.3
Neuroticism	0.1	0.3	0.4	0.6	-0.3
Systolic blood pressure, automated reading	0.1	0.3	0.5	0.2	-0.7
Past tobacco smoking	0.1	0.2	0.4	0.6	0.3
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.5	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.5	-0.0
Neuroticism score	0.1	0.3	0.6	0.8	0.1
Lung cancer (father)	0.1	0.1	0.1	0.4	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.4	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.4	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	0.6	-0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.3	0.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.6	0.3
Number of full sisters	0.1	0.1	0.2	-0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.5	-0.1
Loneliness, isolation	0.1	0.1	0.2	-0.4	-0.3
Breast cancer (self-reported)	0.1	0.1	0.2	-0.0	-0.5
Smoking status: Current	0.1	0.1	0.3	-0.1	-0.5
Mother’s age at death	0.1	0.1	0.2	0.2	0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	0.3	-0.1
Irritability	0.1	0.1	0.2	-0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	0.6	0.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.5	0.2
Breast Cancer	0.0	0.1	0.1	0.3	-0.3
Blood Eosinophil Count	0.0	0.1	0.2	-0.4	0.0
Tanning	0.0	0.5	1.0	0.2	-1.0
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	-0.0	0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	0.0	0.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	-0.2	-0.3
Fluid intelligence score	0.0	0.1	0.1	0.3	-0.2
Blood clot in the leg (DVT)	0.0	0.1	0.1	-0.2	0.2
Emphysema/chronic bronchitis	0.0	0.0	0.1	-0.1	-0.3
Migraine (self-reported)	0.0	0.1	0.1	0.3	0.2
Medication: Omeprazole	0.0	0.0	0.1	0.2	-0.2
Heart disease (mother)	0.0	0.0	0.0	0.0	0.0
Smoking status: Previous	0.0	0.0	0.0	-0.2	-0.2
Ever had bowel cancer screening	0.0	0.0	0.0	0.1	-0.2
Qualifications: nursing, teaching	0.0	0.0	0.0	-0.2	-0.1
Myopia	0.0	0.1	0.1	0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	-0.2	-0.0

Hub : Genes

EDNRB

Models

Trait associations