TWAS hub - EEF2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1150	0.0510	0.0070	-0.003	NA	-0.003	NA	-0.003	0.53000	NA	0.51000	NA	0.5700
2	TCGA	Lung Squamous Cell Carcinoma	0.0875	0.0547	0.0061	0.026	0.008	0.025	NA	0.019	0.00058	0.035	0.00075	NA	0.0028
3	TCGA	Rectum Adenocarcinoma	0.2110	0.1010	0.0067	-0.011	0.050	0.045	NA	-0.008	0.71000	0.026	0.03300	NA	0.5600

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Osteoarthritis (self-reported)	4.8	6.2	12.7	-1.1	-3.6	2.2
Allergy	3.9	8.9	11.3	3.4	-2.3	3.2
Respiratory disease	3.7	8.2	22.6	-4.8	0.3	-1.4
Supplements: Vitamin C	3.6	4.3	7.6	-0.5	2.8	-2.2
Supplements: Calcium	3.5	3.8	11.3	-3.4	-0.4	-0.0
Length of working week for main job	3.3	3.7	11.0	-3.3	-0.2	-0.2
Neck or shoulder pain in last month	3.2	4.5	7.8	0.3	2.8	-2.4
Asthma (self-reported)	3.2	6.3	12.5	-3.5	0.4	-2.5
Number of operations (self-reported)	3.2	4.8	8.0	-2.1	-2.8	1.4
Asthma	3.1	6.1	12.7	-3.6	0.5	-2.3
Qualifications: nursing, teaching	3.1	4.9	11.4	-3.4	1.6	-0.8
Fractured/broken bones in last 5 years	3.1	3.9	6.2	-1.0	2.2	-2.5
Type 2 Diabetes (T2D) (2018)	3.0	5.7	14.2	-3.8	1.7	-0.1
HDL Cholesterol	2.9	4.8	14.5	-0.1	0.0	-3.8
Mineral and other dietary supplements	2.8	3.7	10.5	3.2	0.6	-0.6
Exposure to tobacco smoke outside home	2.7	3.6	4.9	2.2	-1.3	-2.1
Leg pain on walking	2.6	3.2	5.5	-1.0	1.8	-2.4
Tinnitus: Yes, but not now, but have in the past	2.5	2.6	3.9	-1.8	2.0	0.8
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	7.0	0.1	0.7	2.6
Back pain experienced in last month	2.2	3.2	5.0	-2.2	1.6	-1.4
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	6.2	-0.3	-2.5	1.4
Noisy workplace	2.1	2.6	4.9	-0.9	2.2	-1.4
Ever had hysterectomy (womb removed)	2.0	2.2	4.8	-1.4	-2.2	-0.2
Supplements: Zinc	2.0	2.2	4.4	-2.1	1.4	0.6
Blood Red Count	1.9	18.7	52.0	-7.2	0.7	-1.9
Qualifications: A levels/AS levels or equivalent	1.9	4.3	12.9	-3.6	-0.2	-0.1
Prospective memory result	1.9	2.3	3.8	-1.0	1.5	-1.9
Hair/balding pattern: Pattern 4	1.8	4.3	8.8	-0.5	2.0	-3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	3.4	-1.8	-1.9	0.4
Qualifications: College or University degree	1.8	5.8	13.5	-3.7	-1.3	1.5
Illnesses of siblings: Diabetes	1.8	2.2	4.4	-1.3	-0.8	2.1
Ever had bowel cancer screening	1.8	2.1	4.2	-0.0	-2.1	1.4
HbA1C	1.7	1.9	4.0	-2.0	0.0	-1.3
LDL Cholesterol	1.7	2.7	7.5	-2.7	0.0	-0.9
Ever used hormone-replacement therapy (HRT)	1.7	2.1	3.4	-1.8	-1.8	-0.1
Medication: Atenolol	1.7	2.1	3.2	-1.8	0.8	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	4.6	-0.6	-2.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	5.2	-2.3	-0.5	0.3
Friendships satisfaction	1.7	2.1	5.3	-0.3	2.3	1.0
Pain experienced in last month	1.7	2.9	6.6	0.9	-2.6	1.1
Hayfever, allergic rhinitis or eczema	1.6	3.4	5.6	-1.8	1.1	-2.4
Chronic bronchitis/emphysema (father)	1.6	1.9	3.3	-0.5	1.8	-1.4
Diabetes (self-reported)	1.6	2.5	3.9	-2.0	1.6	1.0
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	5.4	-0.4	0.8	-2.3
Heel T-Score	1.5	11.8	19.3	-3.5	-1.9	4.4
Chronotype (morning person)	1.5	3.5	8.9	3.0	-0.2	-1.3
Age when periods started (menarche)	1.5	3.6	10.2	-0.5	3.2	0.7
Pulse rate, automated reading	1.5	4.8	7.3	0.5	-2.7	2.6
Diabetes diagnosed by doctor	1.5	2.5	4.6	-2.1	1.6	0.6
Relative age voice broke	1.4	2.1	4.2	-2.1	-0.6	1.3
Had menopause	1.4	1.8	4.6	-2.1	-0.7	-0.6
Had other major operations	1.4	1.7	3.0	-1.7	-1.3	0.7
Financial difficulties in last 2 years	1.4	1.8	3.0	-0.8	1.4	-1.7
Happiness	1.4	1.7	4.0	-0.8	2.0	-0.6
Headache pain in last month	1.4	2.4	4.9	2.2	1.4	0.5
Mouth/teeth dental problems: Loose teeth	1.4	1.6	2.6	1.6	-0.8	1.3
Number of full sisters	1.4	1.7	4.0	2.0	0.6	-0.9
Medication: Aspirin	1.4	1.8	3.6	-0.7	1.9	1.1
Relative age of first facial hair	1.3	2.6	5.1	-2.2	0.6	1.5
Supplements: Glucosamine	1.3	1.7	3.1	-1.5	0.1	1.8
High blood pressure (mother)	1.3	1.8	4.1	2.0	1.1	-0.4
Falls in the last year	1.3	1.7	3.7	-1.9	-1.0	-0.7
Medication: Seretide 50 evohaler	1.3	1.4	4.0	-2.0	-0.6	0.0
Neuroticism (2016)	1.2	1.8	3.7	-0.8	-1.9	-1.0
Hearing difficulty/problems: Yes	1.2	1.9	5.5	-2.3	-0.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	4.9	-0.0	0.3	-2.2
Worry too long after embarrassment	1.2	2.0	3.5	0.1	1.6	-1.9
Age at last live birth	1.2	1.8	5.3	-2.3	-0.0	0.0
Loneliness, isolation	1.2	1.6	4.3	-0.7	0.3	-2.1
Eye problems/disorders: Cataract	1.2	1.4	2.8	-1.2	-1.7	-0.0
Miserableness	1.2	2.0	2.9	0.9	1.5	-1.7
Medication: Lisinopril	1.2	1.5	4.5	-0.2	2.1	-0.2
Ever depressed for a whole week	1.2	1.5	3.6	-1.9	0.4	-0.8
Alzheimer’s Disease (in father)	1.1	1.2	3.0	0.3	-1.7	-0.7
Primary Biliary Cirrhosis	1.1	1.6	3.3	-1.8	1.1	0.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.0	-0.4	-1.7	0.9
High blood pressure	1.1	3.2	9.4	0.3	3.1	0.1
Stomach or abdominal pain in last month	1.1	1.4	2.4	1.6	0.2	1.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	2.6	0.6	1.0	-1.6
Time employed in main current job	1.1	1.3	2.1	-1.4	0.9	-1.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.9	-2.0	0.6	-1.0
Shortness of breath walking on level ground	1.1	1.3	1.9	-1.4	1.4	0.1
Hypertension (Self-reported)	1.1	3.1	8.8	0.2	3.0	0.5
Average weekly red wine intake	1.1	1.6	4.2	-0.6	-2.1	0.4
Illnesses of father: None of the above (group 1)	1.1	1.4	3.3	-0.5	-0.8	1.8
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.5	-0.9	-0.8	1.6
Illnesses of father: High blood pressure	1.1	1.3	3.3	0.5	1.8	-0.6
Diastolic blood pressure, automated reading	1.1	3.3	5.9	0.3	2.0	-2.4
Average weekly spirits intake	1.0	1.3	1.7	1.2	1.3	-0.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.7	-0.8	-1.3	1.0
Mouth/teeth dental problems	1.0	1.5	4.2	0.0	-0.4	-2.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.4	-0.9	1.2	-1.2
Commuting to job workplace: Car/motor vehicle	1.0	1.2	1.9	-1.1	1.4	0.7
Osteoporosis (self-reported)	1.0	1.3	2.0	1.4	0.0	-1.4
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.8	-1.9	-0.2	0.1
Vascular/heart problems diagnosed by doctor	1.0	2.8	7.9	-0.7	-2.8	-0.2
Ulcerative Colitis (UC)	0.9	1.6	2.8	1.1	1.0	-1.7
Verbal and Numeric Reasoning (VNR)	0.9	2.2	6.5	-2.5	0.3	0.4
Lung FEV1/FVC ratio	0.9	4.5	9.3	3.0	0.9	-1.9
Lung FVC	0.9	4.4	6.2	-1.1	-2.4	2.5
Systolic blood pressure, automated reading	0.9	2.6	4.3	-0.8	2.1	-1.7
Impedance of leg (left)	0.9	4.3	11.8	3.4	-0.9	0.7
Nervous feelings	0.9	1.8	3.0	-0.7	1.3	-1.7
Exposure to tobacco smoke at home	0.9	1.0	2.7	1.6	-0.1	-0.5
Had major operations	0.9	1.0	1.7	-1.3	-0.9	-0.7
Long-standing illness, disability or infirmity	0.9	1.4	3.1	-1.1	1.8	-0.1
Hearing aid user	0.9	1.1	2.5	-0.1	0.8	-1.6
Commuting to job workplace: Public transport	0.9	1.0	2.8	-0.3	-1.7	0.5
Alcohol drinker status: Never	0.9	1.1	2.3	1.5	-0.1	1.0
Age started oral contraceptive pill	0.9	1.1	1.9	-0.9	-1.4	-0.7
Basal cell carcinoma (self-reported)	0.9	1.1	2.4	0.9	-0.2	-1.6
Fasting Glucose	0.8	0.9	1.8	0.8	-1.4	0.5
Lupus	0.8	1.2	1.8	0.8	-1.3	-1.2
Medication: Co-codamol	0.8	0.9	2.2	0.5	-0.5	-1.5
Taking other prescription medications	0.8	1.2	1.9	-1.3	-0.1	-1.4
Qualifications: None of the above	0.8	1.8	4.7	2.2	-0.8	0.2
Mouth/teeth dental problems: Dentures	0.8	1.4	2.6	1.2	-0.1	1.6
Lung cancer (father)	0.8	0.9	1.8	-1.0	1.4	0.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.4	-1.0	-0.6	-1.2
Medication: Omeprazole	0.8	1.0	1.5	-0.8	0.9	-1.2
Breast cancer (self-reported)	0.8	0.9	2.2	0.6	1.5	0.4
Eye problems/disorders: Glaucoma	0.8	0.9	1.6	-0.2	1.1	-1.3
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.6	0.6	-1.2	1.0
Myopia	0.8	1.1	3.1	-0.1	0.4	-1.8
Alcohol drinker status: Previous	0.8	0.9	2.1	-1.4	-0.1	0.8
Pack years of smoking	0.8	1.1	2.5	0.4	-0.9	1.6
Depression (Nagel 2018)	0.7	1.1	3.1	0.3	-0.2	-1.8
Cardiovascular Disease	0.7	2.2	5.4	-1.0	2.3	0.0
Vitamin and mineral supplements	0.7	1.0	2.6	0.4	-0.5	1.6
Pack years adult smoking proportion	0.7	1.0	2.3	0.5	-0.6	1.5
Impedance of leg (right)	0.7	3.5	9.9	3.1	-0.8	0.3
Current tobacco smoking	0.7	1.1	2.5	-0.8	-0.5	-1.6
Qualifications: CSEs or equivalent	0.7	0.9	1.3	1.1	1.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.0	-1.2	0.1	-1.4
Hearing difficulty/problems with background noise	0.7	1.0	2.1	-1.4	0.2	-1.0
Father’s age at death	0.7	0.9	1.7	-1.3	-1.0	0.1
Illnesses of mother	0.7	0.9	1.5	-0.6	-1.2	-0.8
Impedance of arm (left)	0.7	3.2	6.4	2.5	-0.5	-1.7
Medication: Amlodipine	0.7	1.0	2.6	0.5	0.2	1.6
Wheeze or whistling in the chest in last year	0.7	1.3	3.4	-1.8	0.3	-0.7
Number of children fathered	0.7	0.8	1.3	-0.2	-1.0	1.2
Eye problems/disorders: None of the above	0.7	0.9	2.3	0.5	1.5	-0.0
Migraine (self-reported)	0.7	0.9	1.4	1.2	0.4	1.1
Suffer from ‘nerves’	0.7	1.0	2.3	-0.8	1.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.6	0.9	1.3	-0.3
Medication: Aspirin	0.7	1.0	1.9	-0.6	1.4	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.4	1.2	-1.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.3	-1.1	-1.1	0.5
Medication: Blood pressure	0.7	1.4	2.3	-0.7	1.5	1.2
Medication: Atorvastatin	0.7	0.8	2.0	-1.4	-0.7	0.1
Impedance of whole body	0.7	3.7	10.0	3.2	-0.7	-0.8
Neuroticism (Nagel 2018)	0.6	1.4	2.3	1.3	-0.2	-1.5
Allergy or Eczema	0.6	1.5	3.1	-1.7	0.9	-0.8
Angina	0.6	0.8	1.7	0.7	1.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.0	-1.7	-0.6	0.9
Medication: Ramipril	0.6	0.8	2.2	-0.3	1.5	0.4
Impedance of arm (right)	0.6	2.6	4.2	2.1	-0.4	-1.9
Trunk fat-free mass	0.6	3.3	5.0	-2.0	1.0	2.2
Alcohol intake versus 10 years previously	0.6	0.9	1.6	-1.0	1.3	-0.3
Worrier / anxious feelings	0.6	1.1	1.8	-0.1	1.4	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.7	0.3	-1.6	0.3
Pulse wave Arterial Stiffness index	0.6	0.8	0.9	-1.0	1.0	-0.6
Trunk predicted mass	0.6	3.2	4.6	-2.0	1.0	2.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.0	-1.0	0.8	-0.6
Arm fat-free mass (right)	0.6	2.9	3.7	-1.9	1.4	1.7
Medication: Blood pressure	0.6	1.0	2.3	1.5	0.5	0.7
Angina (self-reported)	0.6	0.8	1.8	0.6	1.4	-0.3
Medication: Ibuprofen	0.6	0.7	2.1	-1.4	-0.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.1	-1.0	1.1	0.0
Arm predicted mass (right)	0.6	2.9	4.2	-2.1	1.3	1.7
Chest pain or discomfort	0.6	0.8	1.7	-0.9	-1.3	0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.1	-0.7	0.7	-1.1
Knee pain experienced in last month	0.6	0.9	1.4	-1.1	1.2	-0.1
Medication: Gliclazide	0.6	0.7	2.1	0.2	0.2	1.5
Number of self-reported non-cancer illnesses	0.6	1.0	1.9	-1.1	0.0	1.4
Cholesterol lowering medication	0.6	0.8	2.1	-1.5	0.3	0.6
Arm predicted mass (left)	0.6	3.0	4.1	-2.0	1.4	1.7
Intelligence (Savage-Jansen 2018)	0.5	1.4	4.0	-2.0	-0.4	-0.2
Irritable Bowel Disease (IBD)	0.5	1.1	2.0	0.0	1.1	-1.4
Prostate Cancer	0.5	0.7	2.1	1.4	0.0	0.1
Blood Eosinophil Count	0.5	3.6	8.8	-1.0	1.0	-3.0
Blood White Count	0.5	3.7	10.4	0.8	0.3	-3.2
Waist Hip Ratio (WHR)	0.5	2.1	4.0	0.6	2.0	1.4
Medication: Metformin	0.5	0.7	1.0	-1.0	1.0	0.2
Diabetes (father)	0.5	0.6	0.9	-0.5	0.7	1.0
Diabetes (mother)	0.5	0.6	0.8	0.9	0.5	0.9
Leg fat-free mass (left)	0.5	2.4	3.8	-2.0	1.7	0.6
Serious illness, injury or assault to yourself	0.5	0.6	1.7	1.3	0.1	0.4
Alcohol usually taken with meals	0.5	0.8	2.1	-1.4	-0.5	-0.1
Forced vital capacity (FVC)	0.5	1.8	3.0	-1.0	-1.2	1.7
Heart attack	0.5	0.6	1.4	1.2	0.4	0.4
Medication: Simvastatin	0.5	0.7	1.3	0.4	1.1	-0.8
Fluid intelligence score	0.5	1.1	2.6	-1.6	-0.7	0.5
Illnesses of siblings	0.5	0.8	1.1	1.0	0.9	-0.6
Hair/balding pattern: Pattern 3	0.5	0.8	2.2	1.5	0.4	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.3	1.1	-0.0	1.2
High blood pressure (siblings)	0.5	0.7	1.6	-1.3	-0.5	-0.3
Forced vital capacity (FVC), Best measure	0.5	1.7	3.2	-0.5	-1.3	1.8
Pulse wave peak to peak time	0.5	0.6	0.8	0.9	-0.7	0.7
Medication: Allopurinol	0.5	0.6	1.2	1.1	0.6	0.6
Family relationship satisfaction	0.5	0.6	1.9	-0.1	1.4	0.2
Smoking status: Previous	0.5	0.7	1.5	-0.0	-0.8	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	2.1	0.2	-0.9	1.4
Whole body fat-free mass	0.5	2.8	4.1	-2.0	1.4	1.5
Whole body water mass	0.5	2.9	4.6	-2.1	1.5	1.4
Guilty feelings	0.5	0.8	1.6	0.7	-0.6	-1.3
Mother’s age at death	0.5	0.7	1.0	0.3	1.0	1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	-1.1	0.3	-0.7
Arm fat-free mass (left)	0.5	2.7	3.9	-2.0	1.2	1.7
Irritability	0.5	0.9	2.2	1.5	0.6	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.1	1.1	0.8	0.2
Depressed Affect (Nagel 2018)	0.4	0.9	2.1	0.8	-0.1	-1.5
Reaction Time	0.4	0.7	1.4	0.6	-1.2	0.6
Age at First Birth	0.4	0.6	1.3	-1.1	0.6	-0.4
Number of treatments/medications taken	0.4	0.6	1.5	-1.2	-0.3	0.6
Medication for hormone replacement therapy	0.4	0.5	1.1	-0.3	-1.1	-0.4
Trunk fat percentage	0.4	1.4	2.4	0.3	1.6	-1.3
Maternal smoking around birth	0.4	0.5	1.3	0.2	-1.1	-0.6
Fed-up feelings	0.4	0.8	1.4	0.4	0.8	-1.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.2	-1.1	-0.3	-0.1
Leg predicted mass (left)	0.4	2.4	3.5	-1.9	1.8	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.3	-0.8	-0.2	1.5
Arm fat percentage (right)	0.4	1.5	2.7	-0.4	1.2	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	-1.2	-0.4	-0.1
Medication: Lansoprazole	0.4	0.5	1.0	-0.6	-1.0	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.1	-0.3	0.5	1.1
Blood clot in the leg (DVT)	0.4	0.6	1.0	-0.7	1.0	-0.5
Gout (self-reported)	0.4	0.5	0.9	0.8	1.0	0.1
Leg fat-free mass (right)	0.4	2.2	3.4	-1.8	1.7	0.7
Arm fat percentage (left)	0.4	1.4	2.5	-0.2	1.3	-1.6
Leg predicted mass (right)	0.4	2.2	3.4	-1.8	1.7	0.7
Average weekly champagne plus white wine intake	0.4	0.6	1.3	1.1	0.5	0.3
Ever taken oral contraceptive pill	0.4	0.4	0.9	1.0	-0.1	-0.6
Medication: Bendroflumethiazide	0.4	0.6	1.1	0.8	1.1	0.1
Basal metabolic rate	0.4	2.4	3.5	-1.9	1.5	1.3
Average weekly beer plus cider intake	0.4	0.6	1.3	0.1	0.8	1.1
Commuting to job workplace: Cycle	0.4	0.5	1.5	1.2	0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.0	-0.5	1.0	-0.7
Worry (Nagel 2018)	0.3	0.7	1.3	0.4	0.7	-1.2
Crohns Disease (2017)	0.3	0.7	1.4	-0.9	1.2	-0.1
Breast Cancer	0.3	0.7	1.7	0.1	0.5	-1.3
Crohns Disease (2012)	0.3	0.4	1.0	-0.5	0.0	-1.0
Systolic Blood Pressure	0.3	1.4	3.1	-1.0	1.8	-0.5
Neuroticism	0.3	0.7	1.0	0.9	0.7	-1.0
Tanning	0.3	3.6	6.9	2.6	-1.5	-1.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	-0.4	0.3	-1.0
Hand grip strength (right)	0.3	0.9	1.7	-0.4	1.3	0.9
Townsend deprivation index at recruitment	0.3	0.5	0.9	0.9	-0.7	0.2
Medication: Levothyroxine sodium	0.3	0.5	1.5	1.2	0.0	-0.0
Sitting height	0.3	2.3	4.4	1.4	-0.6	2.1
Body mass index (BMI)	0.3	1.5	2.0	-1.3	1.4	-0.8
Waist circumference	0.3	1.3	2.2	-1.2	1.5	0.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	0.2	1.1	0.4
Pain all over the body in last month	0.3	0.3	0.6	0.8	-0.3	-0.5
Neuroticism score	0.3	0.6	0.9	0.4	1.0	-0.8
Weight	0.3	1.4	2.2	-1.4	1.5	0.4
Hip circumference	0.3	1.4	3.0	-1.7	1.1	-0.3
Arm fat mass (right)	0.3	1.2	1.9	-1.0	1.4	-0.8
Peak expiratory flow (PEF)	0.3	0.6	1.2	-0.4	1.1	0.8
Pulse wave reflection index	0.3	0.4	0.8	0.9	0.5	-0.3
Birth weight	0.3	0.7	1.7	1.3	-0.3	0.7
Body fat percentage	0.3	1.2	2.3	0.1	1.5	-1.2
Leg fat percentage (right)	0.3	0.9	2.0	0.2	1.4	-0.9
Number of full brothers	0.3	0.4	1.2	-0.1	-0.1	-1.1
Age at first live birth	0.3	0.5	0.5	-0.7	-0.5	0.7
Health satisfaction	0.3	0.3	0.8	-0.9	0.4	0.1
Heart disease (mother)	0.3	0.3	0.8	-0.9	-0.3	0.2
Leg fat mass (right)	0.3	1.0	2.8	-0.5	1.7	-0.2
Alcohol intake frequency.	0.3	0.6	1.4	-0.5	1.2	0.4
Illnesses of father: Heart disease	0.3	0.4	0.9	0.4	0.3	-0.9
Mood swings	0.3	0.6	0.9	1.0	0.8	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.6	-0.0	-0.8	0.8
Medication for cholesterol	0.3	0.4	0.5	0.7	-0.5	-0.6
Smoking status: Current	0.3	0.5	1.2	-0.5	-0.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.0	-0.1	-0.8	1.0
Arm fat mass (left)	0.3	1.3	2.2	-0.9	1.5	-0.9
High cholesterol (Self-reported)	0.3	0.5	0.9	0.0	-1.0	-0.7
Medication: Paracetamol	0.3	0.4	1.2	0.1	0.2	1.1
Heart disease (siblings)	0.3	0.4	0.6	-0.2	-0.7	-0.8
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	0.1	-0.5	-0.8
Mean Putamen Volume	0.2	0.2	0.4	-0.2	0.6	-0.3
Rheumatoid Arthritis	0.2	0.3	0.8	0.9	0.0	0.0
Hair Pigment	0.2	6.0	17.1	4.1	-0.7	-0.7
Hand grip strength (left)	0.2	0.4	1.1	-0.4	0.3	1.0
Multivitamins +/- minerals	0.2	0.2	0.2	-0.4	0.5	-0.5
Trunk fat mass	0.2	1.0	2.5	-0.2	1.6	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.5	-0.0	-0.4	1.2
Pulse rate	0.2	0.3	0.7	-0.3	-0.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	0.1	-0.4	1.2
Standing height	0.2	2.1	6.2	-0.1	0.4	2.5
Breastfed as a baby	0.2	0.3	0.7	-0.9	-0.1	-0.2
Birth weight of first child	0.2	0.3	0.9	0.1	0.1	1.0
Loud music exposure frequency	0.2	0.2	0.3	0.3	0.6	-0.4
Comparative body size at age 10	0.2	0.5	1.4	-0.1	0.2	-1.2
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.0	0.0	0.8
Mean time to correctly identify matches	0.2	0.3	0.7	0.3	-0.8	0.3
Whole body fat mass	0.2	0.9	2.6	-0.4	1.6	-0.3
Overall health rating	0.2	0.3	0.4	-0.6	0.6	-0.4
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.7	0.0	0.5
Wears glasses or contact lenses	0.2	0.2	0.4	0.1	-0.5	0.6
Ever smoked	0.2	0.4	1.2	-1.1	0.1	-0.2
Leg fat percentage (left)	0.2	0.7	1.6	0.3	1.3	-0.6
Risk taking	0.2	0.2	0.4	0.2	0.5	0.6
Unable to work because of sickness or disability	0.2	0.2	0.3	0.2	0.6	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.4	0.4	-0.6
Leg fat mass (left)	0.2	0.7	2.0	-0.4	1.4	-0.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.6	-0.1	-0.1
Ovarian Cancer	0.1	0.2	0.3	0.6	-0.5	-0.0
Triglycerides	0.1	0.2	0.3	0.5	0.0	0.6
Blood Platelet Count	0.1	1.6	2.5	-1.2	-1.6	0.9
BMI	0.1	0.4	0.9	-1.0	0.5	0.2
Height	0.1	2.9	6.9	-1.3	0.3	2.6
Smoking Status	0.1	0.4	0.5	-0.7	-0.3	-0.7
Hypothyroidism (self reported)	0.1	0.3	0.5	0.3	-0.5	0.7
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.2	0.6	-0.5
Severe depression (siblings)	0.1	0.1	0.3	-0.5	-0.1	-0.1
Average weekly fortified wine intake	0.1	0.1	0.4	-0.6	-0.0	0.0
Number of incorrect matches in round	0.1	0.1	0.2	0.2	-0.5	-0.2
Past tobacco smoking	0.1	0.3	0.5	0.7	0.1	-0.6
Number of live births	0.1	0.2	0.4	-0.6	-0.1	0.3
Medication: Cholesterol lowering	0.1	0.2	0.5	-0.2	0.0	-0.7
Depression (self-reported)	0.1	0.1	0.1	0.3	0.3	-0.3
Tense / ‘highly strung’	0.1	0.1	0.2	0.3	-0.4	-0.3
Medication: Paracetamol	0.1	0.2	0.5	-0.0	0.7	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	0.5	-0.3	0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.2	-0.5	-0.6
Comparative height size at age 10	0.1	0.8	1.1	1.0	0.6	1.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	-0.3	0.4
Financial situation satisfaction	0.1	0.2	0.4	0.7	0.3	0.1
Bipolar Disorder (2018)	0.0	0.0	0.0	0.2	0.0	0.0
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	-0.1	0.0	0.0
Schizophrenia (2018)	0.0	0.0	0.0	-0.2	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.1	-0.4	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	-0.1	0.0	-0.0
Glaucoma (self-reported)	0.0	0.0	0.1	0.3	0.0	-0.2

Hub : Genes

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Trait associations